基于呋喃-苯亚甲基酮结构的小分子黏度响应型荧光探针及其应用
By designing a small molecule fluorescent probe with a furan-phenylmethylene ketone structure, the problems of high residual fluorescence and insufficient enhancement factor of existing probes at low viscosity are solved, achieving high signal-to-noise ratio and excellent water solubility, making it suitable for high-sensitivity detection in live cell and live in vivo fluorescence imaging.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF HEALTH & MEDICINE HEFEI COMPREHENSIVE NAT SCI CENT
- Filing Date
- 2026-05-07
- Publication Date
- 2026-07-17
AI Technical Summary
Existing viscosity-responsive fluorescent probes have high residual fluorescence at low viscosity, insufficient fluorescence enhancement at high viscosity, large molecular weight, and poor water solubility, resulting in low signal-to-noise ratio and poor biocompatibility, making it difficult to achieve high-sensitivity detection of microenvironment viscosity.
We designed a small molecule fluorescent probe based on the furan-phenylmethylene ketone structure. Utilizing its unique donor-π-acceptor structure, the fluorescence is quenched in a low-viscosity environment and significantly enhanced in a high-viscosity environment, achieving high signal-to-noise ratio, excellent water solubility, and good biocompatibility.
It achieves high sensitivity, quantitative detection, and real-time visualization monitoring of microenvironment viscosity, and provides a high signal-to-noise ratio fluorescence response, suitable for live cell and live in vivo fluorescence imaging.
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