A method for extracting and separating compounds leonurenone C and oresbiusin A from rosemary
Leonurenone C and Oresbiusin A were extracted and separated from rosemary by ethanol solution immersion and multiple separation and purification methods, which solved the problem of lack of extraction and separation methods in the existing technology and realized rapid, green and environmentally friendly large-scale production and bioactivity research.
CN122404435APending Publication Date: 2026-07-17HENAN UNIVERSITY
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HENAN UNIVERSITY
- Filing Date
- 2026-04-29
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
There is currently no effective method for extracting and isolating the compounds leonurenone C and Oresbiusin A from the aerial parts of rosemary.
Method used
Leonurenone C and Oresbiusin A were obtained by ethanol extraction, separation with D101 macroporous resin, normal-phase silica gel column chromatography and gel column chromatography, through gradient elution and multiple separation and purification.
Benefits of technology
A rapid and efficient extraction and separation of leonurenone C and Oresbiusin A from rosemary was achieved. The process is simple, environmentally friendly, and suitable for large-scale production. The compounds exhibit a wide range of biological activities.
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Abstract
本发明公开了一种从迷迭香（Rosmarinus officinalis L.）中提取分离化合物leonurenone C和Oresbiusin A的方法，其选取干燥的迷迭香地上部分为原料，粉碎后用乙醇溶液在室温下浸提，浸提液减压回收溶剂得到总浸膏；总浸膏溶解后用大孔树脂拌样，分别用水与乙醇洗脱，得到Fr A‑Fr D四个组分，再经过不断地分离纯化，得到化合物纯品。本发明提供了一种从迷迭香（Rosmarinus officinalis L.）地上部分中提取分离leonurenone C和Oresbiusin A的方法，有利于更好地开发利用Rosmarinus officinalis L.这一药用植物，有利于植物的可持续利用；本发明提取工艺简单，易得到leonurenone C和Oresbiusin A化合物单体，溶剂可回收利用，提取量大，可工业化生产。
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