一种光电协同催化C端甘氨酸多肽的脱羧芳香酮基化的方法
By using a photoelectrocatalytic synergistic method, cerium and cobalt compounds were used to catalyze the decarboxylation reaction of glycine peptides, successfully constructing peptide compounds with aromatic ketone skeletons. This solved the problems of using precious metals and harsh reaction conditions in existing technologies, and achieved efficient, green and mild synthesis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG UNIV OF TECH
- Filing Date
- 2026-06-18
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for the decarboxylation and aromatic ketation synthesis of glycine peptides face challenges in the use and separation of precious metals, and the reaction conditions are harsh, making it difficult to achieve efficient, green, and economical synthesis.
A photoelectrochemical co-catalysis method was adopted to conduct a one-pot, tandem photo-electrochemical catalysis of the terminal decarboxylation reaction of glycine-containing peptides, generating alkyl free radicals and silyl enol ether addition reactions to construct peptide compounds with aromatic ketone skeletons. Cerium and cobalt compounds were used as catalysts, avoiding the use of oxidants and noble metals.
It achieves efficient, green, and mild decarboxylation and aromatic ketation synthesis of peptides, improves catalytic efficiency, reduces energy consumption, and is suitable for industrial production.
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Figure CN122404471A_ABST