Process for the preparation of fosoliptide

By expressing vosoleptide fusion protein in host cells and utilizing gp55 tagging and acid treatment, the problems of low purity and yield in vosoleptide preparation were solved, achieving efficient and low-cost vosoleptide preparation suitable for various host cells.

CN122404528APending Publication Date: 2026-07-17SHANGHAI DUOMIRUI BIOTECHNOLOGY LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI DUOMIRUI BIOTECHNOLOGY LTD
Filing Date
2025-01-15
Publication Date
2026-07-17

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    Figure BDA0005243900260000121
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Abstract

本发明提供了一种式I所示融合蛋白，其中，A区段是任选的信号肽或者不存在；B区段是gp55融合标签；C区段是伏索利肽的氨基酸序列；“‑”是任选的接头。本发明还提供了利用所述融合蛋白以及表达所述融合蛋白的宿主细胞来制备伏索利肽的方法。本发明的制备伏索利肽的方法具有周期短、成本低、产量高、纯度高以及无需添加变性剂和复性剂等优点。A‑B‑C(I)。
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