一种甲状旁腺激素突变体、含甲状旁腺激素突变体的液体质控品及其应用
By introducing specific amino acid substitutions and forming intramolecular disulfide bonds in PTH molecules, the problem of easy degradation of PTH molecules in quality control materials is solved, achieving a balance between stability and immunoreactivity. It is suitable for multiple detection platforms and meets clinical quality control needs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- JIANGSU LANGDAO BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-06-18
- Publication Date
- 2026-07-17
AI Technical Summary
Existing PTH molecules are easily degraded by enzymes, oxidized, and aggregated in quality control materials, resulting in insufficient stability and affecting the accuracy and consistency of detection. Traditional chemical modification methods cannot simultaneously ensure stability and immunoreactivity.
By introducing specific amino acid substitutions into PTH molecules through site-directed mutagenesis, intramolecular disulfide bonds are formed, blocking enzymatic and oxidative pathways while retaining immunoreactivity characteristics, thus preparing liquid quality control products.
It achieves a balance between long-term stability and immunoreactivity of PTH molecules, is suitable for multiple detection platforms, meets clinical quality control needs, and is easy to industrialize.
Smart Images
Figure CN122404531A_ABST