单克隆抗体组合及其用途、制备方法、试纸条
By screening to obtain a combination of high-titer, non-competing monoclonal antibodies, a double-antibody sandwich colloidal gold test strip for H5 subtype avian influenza virus was prepared, solving the problems of complexity, time consumption, or equipment dependence in existing detection methods, and achieving rapid detection with high sensitivity and specificity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SOUTH CHINA AGRICULTURAL UNIVERSITY
- Filing Date
- 2026-04-20
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for detecting H5 subtype avian influenza virus are complex to operate, time-consuming, or require specialized equipment. Furthermore, existing test strips have low sensitivity and poor specificity, making it difficult to meet the needs of rapid screening.
A monoclonal antibody combination was developed, including a first monoclonal antibody and a second monoclonal antibody. The combination of antibodies with high titers and no mutual competition was obtained through screening. A double-antibody sandwich colloidal gold test strip for H5 subtype avian influenza virus was prepared using colloidal gold labeling technology and antibody coating technology.
It achieves rapid detection of prevalent strains with high sensitivity, strong specificity, and broad coverage, with significant colorimetric effect, meeting the needs of rapid on-site screening.
Smart Images
Figure CN122404544A_ABST