Polypeptides that mimic ngn2 and uses thereof

By designing the Ngn2-mimicking peptide TAT-Ngn2-ELE-1, we were able to reprogram reactive astrocytes in the spinal cord into motor neurons, solving the problem of the lack of effective neuronal regeneration and functional recovery in existing technologies, and providing a new method for SCI treatment.

CN122404569APending Publication Date: 2026-07-17NANTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANTONG UNIV
Filing Date
2026-03-27
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Currently, there are no Ngn2-mimicking peptides that can effectively promote neuronal regeneration and functional recovery in damaged spinal cord.

Method used

A peptide, TAT-Ngn2-ELE-1, mimicking Ngn2, was designed. By screening for the amino acid sequence GRKKRRQRRRPQGGSGHSGQGARGGVAAGAEGCRPARLL and combining it with the spatial structure, the reprogramming of spinal cord reactive astrocytes into motor neuron-like cells was achieved.

Benefits of technology

The TAT-Ngn2-ELE-1 peptide can effectively reprogram mouse spinal cord reactive astrocytes into MAP2+ mature neurons and ChAT+ motor neurons in vitro, providing a new approach to cell replacement therapy after spinal cord injury (SCI) and promoting better SCI repair and functional reconstruction.

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Abstract

本发明公开了一种模拟Ngn2的多肽TAT‑Ngn2‑ELE‑1，所述多肽含39个氨基酸，由促进多肽进入细胞内的TAT序列、连接肽和目标序列构成，所述目标序列为人类Neurogenin‑2蛋白的第61‑80位氨基酸。所述TAT‑Ngn2‑ELE‑1多肽具有类似Ngn2的功能，可以有效将小鼠脊髓反应性星形胶质细胞重编程为运动神经元样细胞。根据此多肽的氨基酸序列和蛋白的空间结构而设计出的新的小分子药物，可大量合成并且在临床上操作简便，为SCI后细胞替换治疗和细胞再生医学研究提供可选择的新途径，进而实现更好的SCI修复和功能重建效果。
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