一种基于柔性可编程磁场的磁珠多模式运动控制方法

The magnetic bead motion control method optimized by flexible programmable magnetic fields and reinforcement learning algorithms solves the problems of single magnetic field mode and low integration in traditional magnetic fields. It realizes three-dimensional chaotic mixing and directional motion of magnetic beads, adapts to different sample and container shapes, and improves the automation and adaptability of sample processing.

CN122411073APending Publication Date: 2026-07-17鲁锦志
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
鲁锦志
Filing Date
2026-06-14
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing technologies, traditional external mechanical oscillations or simple unidirectional rotating magnetic fields are difficult to drive magnetic beads to perform effective three-dimensional motion within a closed reaction vessel. Furthermore, existing magnetic field modes are limited and cannot adapt to samples of different viscosities and motion tasks. They also have low integration and are difficult to fit tightly to the curved surfaces of containers of different shapes.

Method used

A flexible programmable magnetic field is used to closely fit the reaction vessel through a flexible electromagnetic coil array, generating a variety of dynamic magnetic field modes, such as a horizontal eccentric rotation and a vertical pulse composite magnetic field. Combined with reinforcement learning algorithms, the magnetic field parameters are optimized in real time to achieve three-dimensional chaotic mixing and directional motion of the magnetic beads.

Benefits of technology

It achieves efficient mixing uniformity and precise control of directional movement of magnetic beads, adapts to different samples and tasks, simplifies system structure, is applicable to various reaction vessels, and improves automation and adaptability.

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Abstract

本发明公开了一种基于柔性可编程磁场的磁珠多模式运动控制方法。该方法通过柔性电磁线圈阵列贴合于反应容器外壁,利用可编程虚拟磁场中心产生多种工作模式:混合模式下,虚拟中心偏心旋转并叠加垂直脉冲,驱动磁珠三维混沌混合,混合均匀度显著提升;定向模式下,虚拟中心沿预设路径移动,驱动磁珠定向输送,输送速度快、位置精度高。利用强化学习算法实时优化磁场参数,实现自适应智能控制。本发明解决了现有技术功能单一、集成度低、智能化不足的问题,实现了混合与定向的一体化控制,适用于核酸提取、细胞分选、环境监测等各类磁珠法应用场景。
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