Digital microfluidic biochip whole-process comprehensive method, device, equipment and medium

By combining full-process coding and machine learning, the coupling problem of scheduling, layout and routing in the integrated design of digital microfluidic biochips was solved, achieving more efficient chip integration scheme optimization and reducing experimental time.

CN122417128APending Publication Date: 2026-07-17SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Filing Date
2026-03-09
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing integrated design methods for digital microfluidic biochips, the step-by-step integration method cannot fully consider the coupling effects of operation scheduling, module layout and droplet routing, resulting in the transmission of suboptimal constraints and affecting the instruction and routing process of the integrated scheme.

Method used

A comprehensive approach is adopted, which generates an initial chromosome population through full-process coding, performs conflict repair based on position and operation dependencies, uses machine learning to predict droplet routing time, and performs genetic operations based on fitness values ​​to iteratively optimize the chip integration scheme.

Benefits of technology

This effectively avoids the problem of constrained suboptimal transitivity, improves the quality and computational efficiency of the integrated scheme, and shortens the completion time of biological experimental tasks.

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Abstract

本申请公开了一种数字微流控生物芯片的全流程综合方法、装置、设备及介质,所述方法包括依据生化测序图和微流控模块库,通过全流程编码随机生成初始染色体种群;依据位置和操作依赖关系对所述初始染色体种群进行冲突修复以得到微流控模块布局结构;利用机器学习预测所述微流控模块布局结构的液滴路由时间,并基于所述液滴路由时间和操作执行时长计算所述微流控模块布局结构的适应度值;基于所述适应度值对所述初始染色体种群进行遗传操作产生新一代染色体种群,以进行迭代获得芯片综合方案。本申请将操作调度、模块布局与液滴路由三个子问题耦合为一个协同优化过程,然后利用进化算法进行综合方案寻优,打破了人工划分的阶段边界,从根本上避免了约束次优传递问题。此外,本申请在寻优过程中利用全流程编码方式编码生成染色体总群,克服了间接编码导致的搜索空间不完整缺陷的同时,还通过低开销的机器学习代理模型进行液滴路由规划,减少液滴路由的计算时间成本,从而可以降低生物实验任务的完成时间。
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