A glycine oil control composition and method of making same
By combining glycyl glycine, zinc glycine, and modified silica, the problems of insufficient oil control and enlarged pores in oil-controlling skincare products are solved, achieving better oil control and improved skin texture.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUANGZHOU FUMAN BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-06-09
- Publication Date
- 2026-07-21
AI Technical Summary
Existing oil-controlling skincare products are not effective enough in controlling oil, resulting in a persistent oily and sticky face. They also fail to shrink pores, causing rough skin texture, uneven skin quality, and accelerated skin aging.
A glycine oil-controlling composition was prepared by using glycyl glycine, zinc glycine, modified silica, and other components. By introducing hexyl, network structure, hydroxyl and ester groups through modified silica, the adsorption and uniform distribution of oils were improved.
It significantly improves oil control, reduces enlarged pores, enhances skin texture, prevents dryness and sensitivity after oil control, and achieves long-term skin conditioning.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of skincare technology, and in particular to a glycine oil-controlling composition and its preparation method. Background Technology
[0002] Skincare products are daily chemical products primarily designed to cleanse, moisturize, condition, and improve skin condition. They are applied to the skin through smearing, spraying, or pressing, and do not have medicinal therapeutic effects. They are gentle skincare products and fall under the category of cosmetics. The main functions of skincare products include replenishing moisture, repairing the skin barrier, regulating oil production, soothing sensitivity, providing antioxidant protection, and delaying dryness and roughness; their primary focus is on nourishing and conditioning the skin.
[0003] Oil-control skincare products are a major type of skincare product. Their core functions include regulating sebum secretion, absorbing excess oil, minimizing pores, and balancing oil and water levels. Applied to the face and body, they are skincare cosmetics that can improve oily skin, shine, stickiness, enlarged pores, and acne-prone skin. Common ingredients in oil-control skincare products include: oil-controlling active ingredients such as glycine, zinc glycinate, glycyl glycine, zinc salts, and zinc PCA; plant-based extracts such as astringent and oil-controlling extracts from Sophora flavescens root, Zanthoxylum bungeanum fruit, and Centella asiatica; absorbent powders such as silica and silica; and moisturizing and soothing components such as sodium hyaluronate and glycerin.
[0004] Oil-control skincare products are mainly suitable for people with oily skin, combination skin, acne-prone skin, large pores, and those whose faces tend to be shiny daily. They control oil while moisturizing and soothing, preventing dryness and sensitivity after oil control, and are suitable for long-term daily skin conditioning.
[0005] Although there are many types of oil-controlling skincare products on the market, which enhance their oil-controlling performance by adding oil-controlling ingredients, functional additives, and plant extracts, some problems still exist. For example, the oil-controlling effect is insufficient, leaving consumers' faces constantly shiny, greasy, and clogged with pores; the pore-shrinking effect is not good, resulting in rough skin texture, uneven skin quality, and accelerated skin aging.
[0006] In conclusion, it is necessary to develop a new technical solution to address the shortcomings of existing technologies. Summary of the Invention
[0007] This invention provides a glycine oil-controlling composition and its preparation method. The glycine oil-controlling composition includes glycylglycine, zinc glycinate, glycine, modified silica, and other components. The modified silica of this invention introduces various active groups, exhibiting excellent oil-controlling effects and improving the various properties of the product.
[0008] One object of the present invention is to provide a glycine oil-controlling composition, said glycine oil-controlling composition comprising the following components in parts by weight: Glycylglycine 0.1-3 parts Zinc glycinate 0.1-2 parts Glycine 0.1-2 parts 1-10 parts of modified silica 1-20 parts of auxiliary agent 70-100 parts deionized water; The modified silica is obtained by first hydroxylating silica, then reacting it with hexyltrimethoxysilane and KH570 to obtain an intermediate product; finally, the intermediate product, pentaerythritol tetraacrylate, and 2-hydroxyethyl acrylate are blended and reacted.
[0009] Furthermore, the particle size of the silicon dioxide is 50-90 nm.
[0010] Furthermore, the additive is selected from one or more of the following: thickeners, emulsifiers, humectants, skin moisturizers, preservatives, and antioxidants.
[0011] Another object of the present invention is to provide a method for preparing the glycine oil-controlling composition, the method comprising the following steps: S1. Hydroxylated silicon dioxide is obtained by hydroxylating silicon dioxide; S2. The hydroxylated silica, hexyltrimethoxysilane and KH570 are mixed and heated and stirred to react, and an intermediate product is obtained. S3. Under an inert atmosphere, the intermediate product, pentaerythritol tetraacrylate, 2-hydroxyethyl acrylate, and initiator are blended and heated and stirred to obtain modified silica. S4. The modified silica is mixed with the remaining components and stirred to obtain the glycine oil-controlling composition.
[0012] Furthermore, in step S1, the hydroxylation temperature is 70-90°C.
[0013] Furthermore, in step S1, the hydroxylation time is 0.5-2 hours.
[0014] Further, in step S2, the mass ratio of the hydroxylated silica, hexyltrimethoxysilane, and KH570 is (1-3):(0.1-0.5):(0.5-2).
[0015] Furthermore, in step S2, the heating temperature is 50-90℃.
[0016] Further, in step S3, the mass ratio of the intermediate product, pentaerythritol tetraacrylate, and 2-hydroxyethyl acrylate is (1-3):(0.1-0.5):(0.5-2).
[0017] The glycylglycine described in this invention acts on a glycine receptor, causing the glycine receptor to induce Cl... - Influx helps counteract the effects of calcium in cells. 2+ The excess positive charge promotes the normal differentiation of keratinocytes, thereby improving the effect of enlarged pores.
[0018] The present invention has the following beneficial effects: This invention provides a glycine oil-controlling composition and its preparation method. The glycine oil-controlling composition comprises glycylglycine, modified silica, etc. The modified silica is prepared by first hydroxylating silica to obtain hydroxylated silica; then, the hydroxylated silica, hexyltrimethoxysilane, and KH570 are blended and reacted to graft hexyltrimethoxysilane and KH570 onto the surface of the hydroxylated silica to obtain an intermediate product; finally, the intermediate product, pentaerythritol tetraacrylate, and 2-hydroxyethyl acrylate are blended and reacted to undergo polymerization.
[0019] The modified silica of this invention incorporates hexyl groups, a network structure, hydroxyl groups, and ester groups. The hexyl groups alter the surface wettability of the modified silica, giving it lipophilic properties and enabling it to adsorb oil phases. The network structure effectively encapsulates the adsorbed oil phase, improving degreasing effects. The hydroxyl groups interact with oils, enhancing oil adsorption. The ester groups improve the compatibility of the components and promote uniform distribution. Furthermore, silica itself possesses adsorption properties, adsorbing oils from the skin surface. The synergistic effect of these components enhances the overall performance of the product. Detailed Implementation
[0020] To more clearly illustrate the technical solution of the present invention, the following embodiments are provided. Unless otherwise stated, the raw materials, reactions, and post-processing methods appearing in the embodiments are all commercially available raw materials and technical methods well known to those skilled in the art.
[0021] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.
[0022] It should be understood that, except in any operational instance or otherwise indicated, the amounts or all figures representing ingredients used, for example, in the specification and claims, should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximate values varying according to the desired performance to be obtained according to the invention.
[0023] The embodiments of the present invention use the following raw materials: Silica: Particle size 50-90nm.
[0024] Additives: The mixture consists of thickener (xanthan gum, purchased from Shandong Huiheng Biotechnology Co., Ltd.), emulsifier (polyglycerol-10 laurate, CAS No. 34406-66-1, purchased from Zhongshan Dixin Chemical Co., Ltd.), humectant (glycerin, purchased from Shandong Xinmingyang New Materials Co., Ltd.), humectant (1,3-butanediol, purchased from Jining Tangyi Chemical Co., Ltd.), and emollient (grape seed oil, purchased from Hubei Huada Fine Chemical Co., Ltd.) in a mass ratio of 1:2:10:10:1.
[0025] The components and mass fractions of the glycine oil-controlling compositions in Examples 1-3 are shown in Table 1.
[0026] Table 1. Components and mass fractions of the glycine oil-controlling compositions in Examples 1-3 Examples 1-3 A method for preparing a glycine oil-controlling composition, the method comprising the following steps: S1. Immerse silica in a mixed solution of concentrated sulfuric acid and 30wt% hydrogen peroxide at a volume ratio of 7:3, react at 80℃ for 1 hour, filter, wash and dry to obtain hydroxylated silica. S2. Using ethanol and water in a volume ratio of 1:1 as solvents, the hydroxylated silica, hexyltrimethoxysilane, and KH570 were mixed in a mass ratio of 3:0.3:2, heated to 70°C and stirred for 24 hours, then filtered, washed, and dried to obtain the intermediate product. S3. Under a nitrogen atmosphere, using toluene as a solvent, the intermediate product, pentaerythritol tetraacrylate, 2-hydroxyethyl acrylate, and initiator azobisisobutyronitrile were mixed in a mass ratio of 2:0.2:1.5:0.04, heated to 80°C and stirred for 7 hours. The mixture was then filtered, washed, and dried to obtain modified silica. S4. According to the above-mentioned mass proportions, the modified silica is mixed with the remaining components and stirred evenly to obtain the glycine oil-controlling composition.
[0027] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that hexyltrimethoxysilane in S2 is removed, while the remaining components and preparation methods are the same as in Example 1.
[0028] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the pentaerythritol tetraacrylate in S3 is replaced with 2-hydroxyethyl acrylate by mass, while the remaining components and preparation methods are the same as in Example 1.
[0029] Comparative Example 3 Comparative Example 3 is an aqueous solution of 1 wt% glycyl glycine.
[0030] Test Example 1 The performance of the glycine oil-controlling compositions prepared in Examples 1-3 and Comparative Examples 1-2 was tested.
[0031] Test method: (1) Oil control performance: The skin oil content test uses the internationally recognized SEBUMETER method, which is based on the principle of photometry. A special matte tape with a thickness of 0.1mm absorbs the oil on human skin and becomes a semi-transparent tape. The amount of light transmitted will change. The more oil absorbed, the greater the amount of light transmitted, thus measuring the amount of skin oil secretion.
[0032] Twenty-five volunteers with relatively high sebum secretion were selected and divided into five groups of five. For three days prior to the test, volunteers were prohibited from using any oil-control products on their faces. The forehead area of the T-zone was selected as the test site. Basic data were collected first, and then samples were distributed to the volunteers. Each group used the glycine oil-control composition samples prepared in Examples 1-3 and Comparative Examples 1-2, respectively, according to the product instructions, twice a day (morning and evening), for a period of four weeks. Before each data collection, volunteers washed and dried the test area with warm water and waited for two hours in a designated room before data collection. Data was collected three times: before sample use, on day 14 of sample use, and on day 28 of sample use. Three measurements were taken for each test area, and the average value was calculated. Data collection for each follow-up test was ensured to be within the same time period.
[0033] (2) Pore-shrinking properties: Twenty-five volunteers were selected and divided into five groups of five. For three days prior to the test, volunteers were prohibited from using any pore-minimizing products on their faces. The forehead was selected as the test area. First, the initial pore size per unit area was measured using VISIA. Each volunteer was tested three times, and the average value was taken. Then, samples were distributed to the volunteers. Each group of volunteers used the glycine oil-controlling compositions prepared in Examples 1-3 and Comparative Examples 1-2, respectively, according to the product instructions, once in the morning and once in the evening, for a period of two months. Next, the final pore size per unit area was measured using VISIA. Each volunteer was tested three times, and the average value was taken. Finally, the rate of change of the final pore size relative to the initial pore size was calculated.
[0034] The test results are shown in Table 2.
[0035] Table 2 Test Results As can be seen from Table 2, the effects of Examples 1-3 are better than those of Comparative Examples 1-2. This is because the modified silica of Comparative Example 1 does not introduce hexyl groups, which significantly reduces the oil control effect. In contrast, the modified silica of Comparative Example 2 does not introduce a network structure, which reduces the encapsulation effect on skin oil, thus also significantly reducing the oil control effect.
[0036] Test Example 2 The performance of the glycine oil-controlling compositions prepared in Example 1 and Comparative Example 3 was tested.
[0037] Test method: In vitro methods for testing oil control performance: 1. Experimental Objective and Principle: 5α-reductase is a membrane protease dependent on reduced coenzyme II (NADPH) and is an important androgen-metabolizing enzyme in the skin. It irreversibly converts testosterone (T) to dihydrotestosterone (DHT), the most potent androgen, which can induce excessive sebum secretion from the sebaceous glands. Inhibiting 5α-reductase activity to reduce DHT levels can effectively alleviate excessive sebum secretion.
[0038] 2. Relevance of Experimental Methods: This method is an in vitro method, applicable to cosmetics claiming oil-controlling effects. Relevant literature shows a certain correlation between in vivo and in vitro methods. Through experimental design, the 5α-reductase inhibition rate of the sample group (Example 1) was compared with that of the control group (Comparative Example 3) and the blank control group. If the inhibition rate of the sample group was better than (higher than) that of the control group and the blank control group, and the statistical difference P value was <0.05, then the sample group could be considered to have a certain oil-controlling effect.
[0039] 3. The test items are shown in Table 3: Table 3 Test Items 4. Test methods: (1) Take samples of the compositions of Example 1 and Comparative Example 3 respectively for later use, and water is used as the blank control group; (2) Add reagents to the well plate and incubate at 37°C for 10 min; (3) Measure the OD value of each hole using the machine; (4) Record the data and calculate the inhibition rate and statistical difference P value.
[0040] The test results are shown in Table 4.
[0041] Table 4 Test Results Note: ns indicates that the difference is not statistically significant or not statistically significant, in which case P≥0.05; if P<0.05, it indicates that the difference is statistically significant or not statistically significant.
[0042] As shown in Table 4, the inhibition rate of the sample group was better than (higher than) that of the control group and the blank control group, and the statistical difference P value was <0.05, indicating that the difference was significant and the sample group had oil control effect.
[0043] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.
[0044] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.
Claims
1. A glycine oil-controlling composition, characterized in that, The glycine oil-controlling composition comprises the following components in parts by weight: Glycylglycine 0.1-3 parts Zinc glycinate 0.1-2 parts Glycine 0.1-2 parts 1-10 parts of modified silica 1-20 parts of auxiliary agent 70-100 parts deionized water; The modified silica is obtained by first hydroxylating silica, then reacting it with hexyltrimethoxysilane and KH570 to obtain an intermediate product; finally, the intermediate product, pentaerythritol tetraacrylate, and 2-hydroxyethyl acrylate are blended and reacted.
2. The glycine oil-controlling composition according to claim 1, characterized in that, The silica has a particle size of 50-90 nm.
3. The glycine oil-controlling composition according to claim 1, characterized in that, The additives are selected from one or more of the following: thickeners, emulsifiers, humectants, skin moisturizers, preservatives, and antioxidants.
4. A method for preparing the glycine oil-controlling composition according to any one of claims 1-3, characterized in that, The preparation method of the glycine oil-controlling composition includes the following steps: S1. Hydroxylated silicon dioxide is obtained by hydroxylating silicon dioxide; S2. The hydroxylated silica, hexyltrimethoxysilane and KH570 are mixed and heated and stirred to react, and an intermediate product is obtained. S3. Under an inert atmosphere, the intermediate product, pentaerythritol tetraacrylate, 2-hydroxyethyl acrylate, and initiator are blended and heated and stirred to obtain modified silica. S4. The modified silica is mixed with the remaining components and stirred to obtain the glycine oil-controlling composition.
5. The method for preparing the glycine oil-controlling composition according to claim 4, characterized in that, In step S1, the hydroxylation temperature is 70-90°C.
6. The method for preparing the glycine oil-controlling composition according to claim 4, characterized in that, In step S1, the hydroxylation time is 0.5-2 hours.
7. The method for preparing the glycine oil-controlling composition according to claim 4, characterized in that, In step S2, the mass ratio of hydroxylated silica, hexyltrimethoxysilane, and KH570 is (1-3):(0.1-0.5):(0.5-2).
8. The method for preparing the glycine oil-controlling composition according to claim 4, characterized in that, In step S2, the heating temperature is 50-90℃.
9. The method for preparing the glycine oil-controlling composition according to claim 4, characterized in that, In step S3, the mass ratio of the intermediate product, pentaerythritol tetraacrylate, and 2-hydroxyethyl acrylate is (1-3):(0.1-0.5):(0.5-2).