Inhalable cell membrane-coated silk fibroin nanoparticles, and preparation method and application thereof

By preparing inhaled silk fibroin nanoparticles encapsulated in cell membranes, the problems of systemic drug administration side effects and insufficient drug concentration in the treatment of acute pulmonary spasm were solved, achieving precise drug delivery and targeted delivery to the lungs, thus improving the therapeutic effect.

CN122424166APending Publication Date: 2026-07-21ZHEJIANG SCI-TECH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG SCI-TECH UNIV
Filing Date
2026-05-25
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

In existing technologies, treatment options for acute pulmonary spasm suffer from side effects due to systemic administration and insufficient drug concentration at the lesion site. Furthermore, existing nanoparticles have a short residence time in the lungs and low targeting efficiency.

Method used

By using inhaled cell membrane-encapsulated silk fibroin nanoparticles, drug-loaded silk fibroin nanoparticles are blended with cell membranes and extruded using an extruder to prepare nanoparticles with active targeting capabilities, enabling precise drug delivery to the lungs.

Benefits of technology

It significantly improved the therapeutic effect of drugs on pulmonary spasm lesions, reduced the side effects of systemic dosage, prolonged the residence time of nanoparticles in the lungs, and achieved precise drug delivery.

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Abstract

The application discloses inhaled cell membrane-coated silk fibroin nanoparticles and a preparation method and application thereof, and belongs to the field of biological medicines. The preparation method is as follows: freeze-dried silk fibroin is dissolved in water, blended with an anti-airway spasm drug through oscillation, ultrasonic and stirring to obtain drug-loaded silk fibroin nanoparticles, cells are resuspended with a hypotonic solution and then ultrasonically broken to obtain cell homogenate, differential centrifugation is carried out, the obtained precipitate is resuspended and ultrasonically blended with the drug-loaded silk fibroin nanoparticles, and then extruded through an extruder to obtain cell membrane-modified drug-loaded silk fibroin nanoparticles. The material prepared by the method has a core-shell structure, after inhaled administration by atomization, the cell membrane coating makes the nanoparticles have higher lung targeting and longer lung retention time, and realizes more efficient drug enrichment. The anti-spasm drug also shows good ability to relieve acute spasm of the lung.
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