A painkilling preparation of purified active ingredients of kadsurae cortex by atomization inhalation and its preparation method and application

By using molecular encapsulation technology to prepare a nebulized analgesic preparation of purified active ingredients from *Zushima*, the problems of slow onset of action, inconvenient administration, and numerous adverse reactions of *Zushima* preparations have been solved, achieving a non-invasive, rapid, and safe central targeted analgesic effect.

CN122424167APending Publication Date: 2026-07-21GANSU ZUSHIMA PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GANSU ZUSHIMA PHARM CO LTD
Filing Date
2026-06-11
Publication Date
2026-07-21

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Abstract

The application provides a painkilling preparation of purified active ingredient of kadsurae cortex for atomization inhalation and a preparation method and application thereof, and belongs to the technical field of preparations. The raw materials for preparing the painkilling preparation of purified active ingredient of kadsurae cortex for atomization inhalation include 0.5-2 parts of purified kadsurae cortex, 10-20 parts of hydroxypropyl-beta-cyclodextrin, 1.3-2.2 parts of mannitol, 0.5-1 part of a cosolvent, 0.01-0.08 part of a non-ionic surfactant, 1-1.5 parts of a protective agent and 0.01-0.05 part of a chelating agent. The preparation is used for treating acute pain. For the first time, the hydroxypropyl-beta-cyclodextrin inclusion technology is combined with the high-purity active ingredient of kadsurae cortex, a molecular wrapping technology suitable for atomization inhalation is screened out, a kadsurae cortex molecular wrapping compound is prepared, the short board of the medicine prepared from kadsurae cortex, i.e. strong fat solubility, poor solubility, easy agglomeration and respiratory tract stimulation, is solved, and the atomization, stability and biocompatibility of the preparation are significantly improved.
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