A compound prescription for improving microcirculation

Abstract

This invention provides a compound formula for improving microcirculation, relating to the field of traditional Chinese medicine formulas. This compound formula for improving microcirculation comprises the following raw materials in the indicated mass percentages: 55%-62% erythritol, 10%-14% earthworm protein peptide, and the remainder being a traditional Chinese medicine composition. The traditional Chinese medicine composition consists of Gastrodia elata, Eucommia ulmoides leaves, Chaenomeles speciosa, Zaocys dhumnades, Astragalus membranaceus, Prunus persica kernel, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis (processed), and taurine. The four raw materials—Gastrodia elata, Eucommia ulmoides leaves, Chaenomeles speciosa, and Zaocys dhumnades—are in equal proportions, and their total mass accounts for 22%-26% of the total composition. The nine raw materials—Astragalus membranaceus, Prunus persica kernel, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis (processed), and taurine—are in equal proportions, and their total mass accounts for 78%-83% of the total composition. This formula can improve human microcirculation, promote blood circulation, and has anti-thrombotic and thrombolytic effects.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine formula technology, specifically a compound formula for improving microcirculation. Background Technology

[0002] Blood circulation is crucial for maintaining normal physiological functions. When dampness is present in the body, blood viscosity and vascular permeability change, obstructing blood circulation and gradually leading to a sub-healthy state. Many health supplements and medicinal regulators are available on the market. These supplements can promote blood circulation to some extent, but they primarily adjust the macrocirculation to allow the body to heal or repair itself. For individuals with weak constitutions, improving circulation requires not only adjusting the macrocirculation but also the microcirculation to regulate metabolism and transition from a sub-healthy state to a healthy one. Based on the above description, this application proposes a compound formula for improving microcirculation, which can promote metabolic efficiency, enhance health, accelerate blood flow, reduce blood viscosity, increase vascular permeability, and lower blood pressure and blood lipids. Summary of the Invention

[0003] To address the shortcomings of existing technologies, this invention provides a compound formula for improving microcirculation, solving the problem that existing formulas cannot effectively improve the sub-healthy state of human microcirculation.

[0004] To achieve the above objectives, the present invention is implemented through the following technical solution: a compound formula for improving microcirculation, composed of the following raw materials by mass percentage: erythritol 55%-62%, earthworm protein peptide 10%-14%, and the remainder being a traditional Chinese medicine composition;

[0005] The herbal composition consists of Gastrodia elata, Eucommia ulmoides leaves, Chaenomeles speciosa, Zaocys dhumnades, Astragalus membranaceus, Prunus persica kernel, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis (processed), and taurine.

[0006] The four raw materials, namely Gastrodia elata, Eucommia ulmoides leaf, Chaenomeles speciosa and Zaocys dhumnades, are in equal proportions, and the total mass of the four drugs accounts for 22%-26% of the traditional Chinese medicine composition. The nine raw materials, namely Astragalus membranaceus, Prunus persica, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis, and Taurine, are in equal proportions, and the total mass of the nine drugs accounts for 78%-83% of the traditional Chinese medicine composition.

[0007] Preferably, the raw materials are composed of the following percentages by weight: erythritol 55%, earthworm protein peptide 10%, gastrodia elata 5.375%, eucommia ulmoides leaf 5.375%, papaya 5.375%, black-striped snake 5.375%, astragalus membranaceus 1.5%, peach kernel 1.5%, saffron 1.5%, ganoderma lucidum 1.5%, dried tangerine peel 1.5%, cinnamon 1.5%, Sichuan pepper 1.5%, prepared licorice root 1.5%, and taurine 1.5%.

[0008] Preferably, the raw materials are composed of the following ingredients by weight: 2.75g erythritol, 0.5g earthworm protein peptide, 0.26875g gastrodia elata, 0.26875g eucommia ulmoides leaf, 0.26875g papaya, 0.26875g black-striped snake, 0.075g astragalus membranaceus, 0.075g peach kernel, 0.075g saffron, 0.075g ganoderma lucidum, 0.075g dried tangerine peel, 0.075g cinnamon, 0.075g Sichuan pepper, 0.075g roasted licorice root, and 0.075g taurine, for a total weight of 5g.

[0009] Preferred method for preparing a compound formula for improving microcirculation: Weigh the corresponding mass of raw materials, mix the weighed mass of erythritol, earthworm protein peptide, gastrodia elata, eucommia ulmoides leaf, papaya, black-striped snake, astragalus membranaceus, peach kernel, saffron, ganoderma lucidum, tangerine peel, cinnamon, Sichuan pepper, roasted licorice root, and taurine, grind them into a fine powder, and then package them in bags, each bag containing 5 grams.

[0010] This invention provides a compound formula for improving microcirculation. It has the following beneficial effects:

[0011] The formula of this invention, by adding earthworm protein peptides, enables the formula to have the functions of anti-thrombosis, regulating blood pressure, promoting blood circulation, regulating blood viscosity, and dissolving fibrin, thereby improving the microcirculation of the human body. The addition of gastrodia elata, eucommia ulmoides leaves, papaya, black-striped snake, astragalus membranaceus, peach kernel, saffron, ganoderma lucidum, tangerine peel, cinnamon, Sichuan pepper, roasted licorice root, and taurine can clear the meridians, nourish the liver and kidneys, replenish qi and promote blood circulation, improve qi deficiency and fatigue, improve poor qi and blood circulation, strongly promote blood circulation and remove blood stasis, clear the blood vessels throughout the body, improve blood stasis and blockage, and enhance low immunity. Attached Figure Description

[0012] Figure 1 This is a statistical table showing the detection results of the present invention;

[0013] Figure 2 This is a bar chart showing the detection results of the present invention. Detailed Implementation

[0014] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0015] Example 1:

[0016] like Figure 1-2 As shown, this embodiment of the invention provides a compound formula for improving microcirculation, which is composed of the following raw materials by mass percentage: 55% erythritol, 10% earthworm protein peptide, and the remainder being a traditional Chinese medicine composition.

[0017] The herbal composition consists of Gastrodia elata, Eucommia ulmoides leaves, Chaenomeles speciosa, Zaocys dhumnades, Astragalus membranaceus, Prunus persica kernel, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis (processed), and taurine.

[0018] The four raw materials, namely Gastrodia elata, Eucommia ulmoides leaf, Chaenomeles speciosa and Zaocys dhumnades, are in equal proportions, and the total mass of the four drugs accounts for 22% of the traditional Chinese medicine composition. The nine raw materials, namely Astragalus membranaceus, Prunus persica, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis, and Taurine, are in equal proportions, and the total mass of the nine drugs accounts for 78% of the traditional Chinese medicine composition.

[0019] The following experiments verify that this treatment method has the effect of improving human microcirculation:

[0020] The cardiovascular system of zebrafish shares some similarities with that of humans, and blood circulation is crucial for maintaining normal physiological functions. When dampness (a concept in Traditional Chinese Medicine) is present in the body, it can affect blood viscosity and vascular permeability. If a sample can improve this pathological state in the zebrafish, reducing blood viscosity and restoring normal vascular permeability, blood circulation will be smoother. Therefore, the efficacy of the test substance in improving microcirculation can be evaluated by observing the blood flow velocity of the test substance.

[0021] Experimental system: Transgenic vascularized zebrafish;

[0022] Three-day-old (3dpf) post-fertilization AB strain zebrafish were randomly selected and placed in 24-well plates, with 10 zebrafish treated in each well. The samples were administered water-soluble at concentrations of 1000 g / ml, 500 g / ml, and 250 g / ml, with a blank control group included; each well contained 1 mL. One day after treatment, the MTC of the samples on the zebrafish was measured.

[0023] The zebrafish were divided into two groups: a blank control group and a sample treatment group. The blank control group received no treatment, while the sample treatment group received the sample. After a period of cultivation, both groups of zebrafish were observed and photographed using a fluorescence microscope. The images were analyzed using software, and the data from the two groups were compared.

[0024] SPSS 26 software was used for analysis, and GraphPad Prism 8 was used for plotting. Data statistics are expressed as mean and standard deviation. The experimental results were tested for normality using SPSS software. If the data conformed to normality, the significance was determined by the T-parameter test or analysis of variance (ANOVA). If the data did not conform to normality, a non-parametric test was used (P-value < 0.05 indicates statistical significance).

[0025] Compared with the blank control group, the blood flow velocity in the sample treatment group was significantly increased (P<0.05), indicating that the sample has the effect of improving microcirculation.

[0026] like Figure 1 and Figure 2 As shown, the test results are as follows Figure 1 and Figure 2 As shown, this formula has the effect of improving the microcirculation of zebrafish.

[0027] Example 2:

[0028] This invention provides a compound formula for improving microcirculation, composed of the following raw materials in the indicated weight percentages: erythritol 55%, earthworm protein peptide 10%, gastrodia elata 5.375%, eucommia ulmoides leaf 5.375%, papaya 5.375%, zaocys dhumnades 5.375%, astragalus membranaceus 1.5%, peach kernel 1.5%, saffron 1.5%, ganoderma lucidum 1.5%, tangerine peel 1.5%, cinnamon 1.5%, Sichuan pepper 1.5%, prepared licorice root 1.5%, and taurine 1.5%. [The formula is further described by adding...] Earthworm protein peptides give the formula the functions of anti-thrombosis, regulating blood pressure, promoting blood circulation, regulating blood viscosity, and dissolving fibrin, thereby improving the body's microcirculation. The addition of Gastrodia elata, Eucommia ulmoides leaves, papaya, Zaocys dhumnades, Astragalus membranaceus, peach kernel, saffron, Ganoderma lucidum, tangerine peel, cinnamon, Sichuan pepper, roasted licorice root, and taurine can clear the meridians, nourish the liver and kidneys, replenish qi and promote blood circulation, improve qi deficiency and fatigue, improve poor blood circulation, strongly promote blood circulation and remove blood stasis, clear the blood vessels throughout the body, improve blood stasis and blockage, and enhance low immunity.

[0029] Example 3:

[0030] This invention provides a compound formula for improving microcirculation, composed of the following ingredients by weight: 2.75g erythritol, 0.5g earthworm protein peptide, 0.26875g gastrodia elata, 0.26875g eucommia ulmoides leaf, 0.26875g papaya, 0.26875g zaocys dhumnades, 0.075g astragalus membranaceus, 0.075g peach kernel, 0.075g saffron, 0.075g ganoderma lucidum, 0.075g tangerine peel, 0.075g cinnamon, 0.075g Sichuan pepper, 0.075g prepared licorice root, and 0.075g taurine, totaling 5g. Each packet contains 5g, taken three times daily. This formula is relatively easy to take.

[0031] Example 4:

[0032] This invention provides a method for preparing a compound formula for improving microcirculation. The raw materials are weighed according to their respective weights. Erythritol, earthworm protein peptide, Gastrodia elata, Eucommia ulmoides leaves, papaya, Zaocys dhumnades, Astragalus membranaceus, peach kernel, saffron, Ganoderma lucidum, tangerine peel, cinnamon, Sichuan pepper, prepared licorice root, and taurine are mixed and ground into a fine powder, then packaged in 5-gram bags. Gastrodia elata combined with Zaocys dhumnades can dispel wind and unblock meridians, relieve spasms and pain, and improve numbness of limbs, neck, shoulder, waist and leg pain, rheumatic joint discomfort, and stiffness of hands and feet. Eucommia ulmoides leaves can tonify the liver and kidneys, strengthen tendons and bones, stabilize blood pressure, nourish the waist and knees, and relieve soreness and weakness of the waist and knees. Papaya can relax muscles and tendons, resolve dampness and harmonize the stomach, remove dampness from the body, and relieve muscle soreness and cramps. Astragalus membranaceus can greatly replenish vital energy, invigorate qi and promote blood circulation, enhance physical strength, and improve qi deficiency and fatigue, as well as poor blood circulation. Peach kernel combined with saffron can powerfully invigorate blood and remove blood stasis. It can unblock the blood vessels throughout the body, improve blood stasis, cold limbs, and poor blood circulation. Ganoderma lucidum can strengthen the body, calm the mind and help sleep, enhance immunity, regulate the internal organs, and fight fatigue. Dried tangerine peel can regulate qi and strengthen the spleen, dry dampness and resolve phlegm, aid digestion, relieve bloating, harmonize the properties of other medicines and prevent greasiness. Cinnamon and Sichuan pepper can warm the yang and dispel cold, warm the lower jiao, and dispel cold and dampness, improving fear of cold, cold hands and feet, and heavy internal cold. Prepared licorice can harmonize the various medicines, replenish qi and strengthen the middle jiao, moderate the properties of other medicines, and protect the spleen and stomach. Taurine can fight fatigue.

[0033] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A compound formula for improving microcirculation, characterized in that: It is composed of the following raw materials by weight percentage: erythritol 55%-62%, earthworm protein peptide 10%-14%, and the balance being a traditional Chinese medicine composition; The herbal composition consists of Gastrodia elata, Eucommia ulmoides leaves, Chaenomeles speciosa, Zaocys dhumnades, Astragalus membranaceus, Prunus persica kernel, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis (processed), and taurine. The four raw materials, namely Gastrodia elata, Eucommia ulmoides leaf, Chaenomeles speciosa and Zaocys dhumnades, are in equal proportions, and the total mass of the four drugs accounts for 22%-26% of the traditional Chinese medicine composition. The nine raw materials, namely Astragalus membranaceus, Prunus persica, Saffron, Ganoderma lucidum, Citrus reticulata peel, Cinnamomum cassia, Zanthoxylum bungeanum, Glycyrrhiza uralensis, and Taurine, are in equal proportions, and the total mass of the nine drugs accounts for 78%-83% of the traditional Chinese medicine composition.

2. The compound formula for improving microcirculation according to claim 1, characterized in that: It is composed of the following ingredients by weight percentage: erythritol 55%, earthworm protein peptide 10%, gastrodia elata 5.375%, eucommia ulmoides leaf 5.375%, papaya 5.375%, black-striped snake 5.375%, astragalus membranaceus 1.5%, peach kernel 1.5%, saffron 1.5%, ganoderma lucidum 1.5%, dried tangerine peel 1.5%, cinnamon 1.5%, Sichuan pepper 1.5%, prepared licorice root 1.5%, and taurine 1.5%.

3. A compound formula for improving microcirculation according to claim 2, characterized in that: It is composed of the following ingredients by weight: 2.75g erythritol, 0.5g earthworm protein peptide, 0.26875g gastrodia elata, 0.26875g eucommia ulmoides leaf, 0.26875g papaya, 0.26875g black-striped snake, 0.075g astragalus membranaceus, 0.075g peach kernel, 0.075g saffron, 0.075g ganoderma lucidum, 0.075g dried tangerine peel, 0.075g cinnamon, 0.075g Sichuan pepper, 0.075g roasted licorice root, and 0.075g taurine, for a total weight of 5g.

4. The preparation method of the compound formula for improving microcirculation according to claim 3, characterized in that: Weigh the corresponding mass of raw materials, mix the weighed erythritol, earthworm protein peptide, gastrodia elata, eucommia ulmoides leaf, papaya, black-striped snake, astragalus, peach kernel, saffron, ganoderma lucidum, dried tangerine peel, cinnamon, Sichuan pepper, roasted licorice, and taurine, grind them into a fine powder, and then pack them into bags, each bag containing 5 grams.

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