Multi-responsive traceable targeted multi-drug co-delivery nanomicelles, preparation method and application thereof

By designing multi-responsive nanomicelles and combining them with pH and redox-sensitive linkers, precise drug release and active targeting at tumor sites were achieved. This solved the problems of inaccurate drug release, limited tumor targeting ability, and single structure and function in existing nanodelivery systems, enabling chemotherapy-immunotherapy combination therapy and visual tracing.

CN122424352APending Publication Date: 2026-07-21THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
Filing Date
2026-04-22
Publication Date
2026-07-21

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Abstract

The application relates to the technical field of medicines, and particularly discloses a multi-response traceable targeted multi-drug co-delivery nanomicelle as well as a preparation method and application thereof. The nanomicelle is formed by synergistic assembly of a molecule A and a molecule B through electrostatic and hydrophobic interactions; the molecule A is mPEG-targeting ligand-pH sensitive bond-cationic hydrophobic chain, and the molecule B is an anionic hydrophilic segment P-disulfide bond-0831A-hydrophobic tail. The pH sensitive bond and the disulfide bond are introduced to realize dual-response cascade release of a tumor microenvironment pH / oxidation-reduction, and the problem of inaccurate single pH response release is solved; active targeting is realized through the targeting ligand, and the problem of low passive targeting enrichment efficiency is solved. The nanomicelle has good stability, high bioavailability, can significantly enhance the antitumor efficacy and reduce the systemic toxicity, and has a wide application prospect in the preparation of antitumor drugs.
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