Microneedle patch

Abstract

A microneedle patch includes a substrate layer, an adhesive layer, and a microneedle layer. The substrate layer has a surface. The adhesive layer has a first surface and a first surrounding side. The first surface is connected to the surface, and the first surrounding side stands on a side of the first surface opposite the substrate layer. The microneedle layer has a second surface and a second surrounding side. The second surface is connected to a side of the adhesive layer opposite the substrate layer, and the second surrounding side stands on a side of the second surface opposite the adhesive layer. The second surrounding side is flush with or protrudes from the first surrounding side.

Description

Technical Field

[0001] This invention relates to a patch, and more particularly to a microneedle patch. Background Technology

[0002] Microneedle patches (MNPs) are a novel transdermal drug delivery system (TDDS). The microneedles on the patch are very short and do not touch nerves, eliminating the pain associated with subcutaneous injections. They can also carry bioactive ingredients or drugs across the stratum corneum into the body. Microneedle patches can be used in various fields such as aesthetic medicine, pharmaceuticals, and preventative medicine.

[0003] However, existing microneedle patches often stick to skin and hair, which can cause secondary damage to existing skin wounds when removing the patches, or cause discomfort from pulling on hair. Furthermore, the aforementioned problem of hair adhesion also makes it difficult for microneedle patches to adhere firmly to the skin. Summary of the Invention

[0004] This invention provides a microneedle patch to improve the problem of adhesion to skin or hair during use.

[0005] To achieve one or more of the above-mentioned objectives, or other objectives, an embodiment of the present invention provides a microneedle patch, comprising a substrate layer, an adhesive layer, and a microneedle layer. The substrate layer has a surface. The adhesive layer has a first surface and a first surrounding side surface. The first surface is connected to the substrate layer, and the first surrounding side surface stands on the side of the first surface opposite to the substrate layer. The microneedle layer has a second surface and a second surrounding side surface. The second surface is connected to the side of the adhesive layer opposite to the substrate layer, and the second surrounding side surface stands on the side of the second surface opposite to the adhesive layer. The second surrounding side surface is flush with or protrudes from the first surrounding side surface.

[0006] In one embodiment of the present invention, the first surrounding side surface has a first orthographic projection formed on its surface, and the second surrounding side surface has a second orthographic projection formed on its surface. The second orthographic projection may overlap with or surround the first orthographic projection.

[0007] In one embodiment of the present invention, the microneedle layer may have a base and a plurality of microneedles, the base having a third surface. A second surface is located on one side of the adhesive layer connecting the base. The third surface is opposite to the second surface, and the microneedles stand on the third surface. The radius of curvature of the third surface is ≥0.5 cm.

[0008] In one embodiment of the present invention, the microneedle patch further includes, for example, an anti-bending layer. The anti-bending layer is disposed between the substrate layer and the adhesive layer, and the hardness of the anti-bending layer is greater than the hardness of the substrate layer.

[0009] In one embodiment of the present invention, the material of the bending layer may include plastic or silicone.

[0010] In one embodiment of the present invention, the substrate layer may be tubular in shape and its surface may include the outer peripheral surface of the substrate layer.

[0011] In one embodiment of the present invention, the substrate layer described above may include a curved plate. The curved plate has opposing concave and convex surfaces, with the surface including the convex surface.

[0012] In one embodiment of the present invention, the microneedle layer described above may have a base and a plurality of microneedles, the base having a third surface. A second surface is located on one side of the adhesive layer connecting the base. The third surface is opposite to the second surface, and the microneedles stand on the third surface. Each microneedle has an opposing bottom end and a tip, and the bottom end is connected to the third surface. Each microneedle has a length between its bottom end and tip, for example, between 100 μm and 1000 μm.

[0013] In one embodiment of the present invention, the material of the substrate layer may include synthetic polymer materials, cloth, ceramics or metals.

[0014] In one embodiment of the present invention, the material of the adhesive layer may include silicone, acrylic adhesive or hydrogel.

[0015] In the microneedle patch of the present invention, the second circumferential side of the microneedle layer is flush with or protrudes from the first circumferential side of the adhesive layer, allowing the microneedle layer to completely cover the adhesive layer on the substrate layer. Therefore, when the microneedle layer is inserted into the skin, it effectively separates the adhesive layer from the skin, preventing the adhesive layer from contacting the skin. Based on the above, the microneedle patch of the present invention effectively improves the problem of adhesion to skin and hair during use.

[0016] To make the above and other objects, features and advantages of the present invention more apparent and understandable, specific embodiments are described below in conjunction with the accompanying drawings. Attached Figure Description

[0017] Figure 1 This is a cross-sectional schematic diagram of a microneedle patch according to an embodiment of the present invention.

[0018] Figure 2 yes Figure 1 A schematic diagram of the first and second surrounding sides projected onto the substrate layer.

[0019] Figure 3 This is a cross-sectional schematic diagram of a microneedle patch according to another embodiment of the present invention.

[0020] Figure 4 yes Figure 3 A schematic diagram of the first and second surrounding sides projected onto the substrate layer.

[0021] Figure 5 This is a schematic diagram of a microneedle patch according to another embodiment of the present invention.

[0022] Figure 6 This is a top view schematic diagram of a microneedle patch according to another embodiment of the present invention.

[0023] Figure 7 yes Figure 6 A cross-sectional schematic diagram of the microneedle patch.

[0024] Figure 8 This is a schematic diagram of a microneedle patch according to another embodiment of the present invention.

[0025] Figure 9 This is a cross-sectional schematic diagram of a microneedle patch according to another embodiment of the present invention.

[0026] Figure 10 This is a schematic diagram of a microneedle patch according to another embodiment of the present invention.

[0027] In the attached figures, the following labels are used:

[0028] 100, 100a, 100b, 100c, 100d, 100e, 100f, 100g: Microneedle Patches

[0029] 110, 110c, 110d, 110e, 110f, 110g: Substrate layer

[0030] 111: Surface

[0031] 112d: Convex surface

[0032] 113d: Concave surface

[0033] 120, 120a: Adhesive layer

[0034] 121: First Surface

[0035] 122, 122a: First surrounding side

[0036] 123: Surface

[0037] 130: Microneedle layer

[0038] 131: Second Surface

[0039] 132: Second surrounding side

[0040] 133: Base

[0041] 134: Microneedle area

[0042] 140: Bending resistance layer

[0043] 141, 142: Surface

[0044] 1330: Third Surface

[0045] B: Bottom

[0046] C: Curved plate

[0047] H, Hg: Hard parts

[0048] L: Length

[0049] N: Normal direction

[0050] P1, P1a: First orthographic projection

[0051] P2: Second Orthographic Projection

[0052] R, Rg: Deformation parts

[0053] T: Tip Detailed Implementation

[0054] The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments, but this is not intended to limit the present invention.

[0055] Figure 1 This is a cross-sectional schematic diagram of a microneedle patch according to an embodiment of the present invention. Please refer to it first. Figure 1 The microneedle patch 100 includes a substrate layer 110, an adhesive layer 120, and a microneedle layer 130. The substrate layer 110 has a surface 111. The adhesive layer 120 has a first surface 121 and a first surrounding side 122. The first surface 121 is connected to the surface 111, and the first surrounding side 122 is positioned on the side of the first surface 121 opposite to the substrate layer 110. The microneedle layer 130 has a second surface 131 and a second surrounding side 132. The second surface 131 is connected to the side of the adhesive layer 120 opposite to the substrate layer 110, and the second surrounding side 132 is positioned on the side of the second surface 131 opposite to the adhesive layer 120. The second surrounding side 132 is flush with the first surrounding side 122.

[0056] The material of the substrate layer 110 may include synthetic polymers, fabric, ceramics, or metals. For example, the material of the substrate layer 110 in this embodiment may include a polymer. In one embodiment, the material of the substrate layer 110 may include fabric and may be shaped to be wearable; detailed features will be described in subsequent paragraphs.

[0057] Figure 2 yes Figure 1 A schematic diagram showing the orthographic projection of the first and second surrounding sides onto the substrate layer. Please refer to... Figure 1 and Figure 2The adhesive layer 120 connects the substrate layer 110 and the microneedle layer 130. On the normal N of the first surface 121, the first surrounding side 122 of the adhesive layer 120 does not extend beyond the second surrounding side 132 of the microneedle layer 130. For example, in this embodiment, the first surrounding side 122 has a first orthographic projection P1 formed on the surface 111, and the second surrounding side 132 has a second orthographic projection P2 formed on the surface 111. The second orthographic projection P2 may overlap the first orthographic projection P1. For example, the first orthographic projection P1 overlaps the second orthographic projection P2, and the area of ​​the first orthographic projection P1 is the same as the area of ​​the second orthographic projection P2. In other words, the first surrounding side 122 and the second surrounding side 132 are tangent to each other on the normal N, and the microneedle layer 130 completely covers the surface 123 of the adhesive layer 120 opposite to the first surface 121. Thus, when the microneedle patch 100 is applied to the skin, the microneedle layer 130 can separate the skin from the adhesive layer 120 to prevent the adhesive layer 120 from sticking to the skin or hair. The material of the adhesive layer 120 may include silicone, acrylic adhesive, or hydrogel, but the present invention is not limited thereto.

[0058] Please continue to refer to this. Figure 1 The microneedle layer 130 may contain a drug to facilitate absorption by the body upon insertion into the skin. Further, the microneedle layer 130 may have a base 133 and a plurality of microneedle portions 134, the base 133 having a third surface 1330. A second surface 131 is located on one side of the adhesive layer 120 connecting the base 133. The third surface 1330 is opposite the second surface 131, and the microneedle portions 134 stand on the third surface 1330, wherein the microneedle portions 134 are adapted to penetrate the skin to deliver the drug. In one embodiment, the third surface 1330 may be substantially planar. In other embodiments, the radius of curvature of the third surface 1330 is ≥0.5 cm, but is not limited thereto. Incidentally, each microneedle portion 134 has an opposing bottom end B and a tip T, and the bottom end B connects to the third surface 1330. Each microneedle portion 134 has a length L between the bottom end B and the tip T, the length L being, for example, between 100 μm and 1000 μm. In this way, each microneedle portion 134 has a sufficient length L to penetrate the skin, while simultaneously preventing the microneedle portion 134 from deforming upon penetration due to excessive length L. In one embodiment, the length L of each microneedle portion 134 is, for example, between 200 μm and 300 μm, but the invention is not limited thereto. Incidentally, the shape of each microneedle portion 134 may be conical or pyramidal.

[0059] Compared to existing technologies, in the microneedle patch 100 of this embodiment, the second circumferential side 132 of the microneedle layer 130 is flush with the first circumferential side 122 of the adhesive layer 120, allowing the microneedle layer 130 to completely cover the adhesive layer 120 on the substrate layer 110. Therefore, when the microneedle layer 130 is inserted into the skin, it effectively separates the adhesive layer 120 from the skin, preventing the adhesive layer 120 from contacting the skin. Based on the above, the microneedle patch 100 of this embodiment effectively improves the problem of adhesion to skin and hair during use.

[0060] Figure 3 This is a cross-sectional schematic diagram of a microneedle patch according to another embodiment of the present invention. Figure 4 yes Figure 3 A schematic diagram of the first and second surrounding sides projected onto the substrate layer. The structure and advantages of the microneedle patch 100a in this embodiment are similar to... Figure 1 The following describes only the differences in the embodiments. Please refer to [the previous text]. Figure 3 and Figure 4 The second surrounding side 132 protrudes beyond the first surrounding side 122a. For example, the first orthographic projection P1a overlaps with the second orthographic projection P2, and the area of ​​the first orthographic projection P1a is smaller than the area of ​​the second orthographic projection P2. In other words, on the surface 111 of the substrate layer 110, the second orthographic projection P2 of the second surrounding side 132 can encircle the first orthographic projection P1a of the first surrounding side 122a. This further ensures that the microneedle layer 130 separates the adhesive layer 120a from the skin when it is inserted, thereby more effectively preventing the adhesive layer 120a from contacting the skin.

[0061] Figure 5 This is a schematic diagram of a microneedle patch according to another embodiment of the present invention. The structure and advantages of the microneedle patches 100b and 100c in this embodiment are similar. Figure 1 The following describes only the differences in the embodiments. Please refer to [the previous text]. Figure 5 In (a), the substrate layer 110c may be tubular in shape, and the surface 111 includes the outer peripheral surface of the substrate layer 110c. This allows the substrate layer 110c to be fitted over a finger, and the microneedle layer 130 to be inserted into the skin by pressing with the finger. Specifically, the microneedle layer 130 may be positioned on the surface 111 (i.e., the aforementioned outer peripheral surface) at a position corresponding to the fingertip, facilitating the user's insertion of the microneedle layer 130 into the skin by pressing with the fingertip. Incidentally, the substrate layer 110c in (a) may be tubular with openings at both ends, and the substrate layer 110d of the microneedle patch 100c in (b) may be tubular with an opening at one end and a closed section at the other. It is understood that the present invention does not impose further limitations on these details.

[0062] Figure 6 This is a top view schematic diagram of a microneedle patch according to another embodiment of the present invention. Figure 7 yes Figure 6A cross-sectional schematic diagram of the microneedle patch. The structure and advantages of the microneedle patch 100d in this embodiment are similar to those of the microneedle patch 100d. Figure 1 The following describes only the differences in the embodiments. Please refer to... Figure 6 and Figure 7 The substrate layer 110d may include a curved plate C. The curved plate C has opposing concave surfaces 113d and convex surfaces 112d, with surface 111 including the convex surface 112d. Further, the concave surface 113d can be fixed to the user's fingertip, while the microneedle layer 130 is located on the convex surface 112d, facilitating the user's insertion of the microneedle layer 130 into the skin by pressing with their fingertip. In this embodiment, the material of the substrate layer 110d may be a polymer, ceramic, or metal, but the invention is not limited thereto.

[0063] Figure 8 This is a schematic diagram of a microneedle patch according to another embodiment of the present invention. The structure and advantages of the microneedle patch 100e in this embodiment are similar to those of... Figure 1 The following describes only the differences in the embodiments. Please refer to... Figure 8 Incidentally, the substrate layer 110e can be made of fabric to adapt to different parts of the human body through the deformable nature of fabric, making the wearing methods of the microneedle patch 100e more diverse. For example, the microneedle patch 100e of this embodiment can be made into a bandage shape. Furthermore, the substrate layer 110e can have a rigid portion H and two deformable portions R, wherein the two deformable portions R can connect opposite sides of the rigid portion H, and the hardness of the rigid portion H is greater than the hardness of the two deformable portions R. The material of the two deformable portions R can include fabric to facilitate deformation to fit the shape of the wearing part. On the other hand, the material of the rigid portion H can include polymer materials, ceramics, or metals to facilitate the fixation of the microneedle layer 130 and prevent the microneedle layer 130 from bending too much. However, the present invention does not impose many restrictions on the material to which the two deformable portions R can connect to the rigid portion H.

[0064] Figure 9 This is a cross-sectional schematic diagram of a microneedle patch according to another embodiment of the present invention. The structure and advantages of the microneedle patch 100f in this embodiment are similar to those of the present invention. Figure 1 The following describes only the differences in the embodiments. Please refer to... Figure 9The microneedle patch 100f also includes, for example, an anti-bending layer 140 disposed between the substrate layer 110 and the adhesive layer 120. Specifically, the radius of curvature of the surface 141 of the anti-bending layer 140 attached to the substrate layer 110 is approximately the same as the radius of curvature of the substrate layer 110, and the radius of curvature of the surface 142 of the anti-bending layer 140 facing the microneedle layer 130 is approximately the same as the radius of curvature of the third surface 1330, preventing the microneedle layer 130 from being excessively bent due to excessive bending of the substrate layer 110, thus preventing the microneedles 134 from becoming excessively bent and misaligned. Therefore, the microneedle patch 100f can reduce the degree of bending of the microneedle layer 130 with the anti-bending layer 140. For example, the microneedle patch 100f can be worn or attached to the human body (e.g., Figure 8 The microneedle patch 100f (100e) allows the substrate layer 110 to be made of a flexible material to adapt to different parts of the human body. Since the microneedles 134 can withstand significant forward pressure but are easily deformed under lateral pressure, the bending layer 140 reduces the bending degree of the microneedle layer 130, allowing each microneedle 134 to maintain a roughly upright posture when inserted into the skin. In one embodiment, the microneedle patch 100f uses the bending layer 140 to control the radius of curvature of the third surface 1330 to ≥0.5 cm, allowing the microneedle layer 130 to be inserted into the skin more upright and evenly. It is understood that in other embodiments, the microneedle patch 100f is not limited to being worn or attached to the human body, and the present invention does not impose further limitations on this. In this embodiment, the material of the bending layer 140 may include plastic or silicone, but the present invention is not limited to these. Incidentally, the shape of the bending layer 140 may be flat or curved, and other embodiments are not limited to these.

[0065] Figure 10 This is a schematic diagram of a microneedle patch according to another embodiment of the present invention. The structure and advantages of the 100g microneedle patch in this embodiment are similar to those of the present invention. Figure 1 The following describes only the differences in the embodiments. Please refer to... Figure 10 The deformable portion Rg of the substrate layer 110g can be made into a glove shape to facilitate wearing on the hand. Similarly, in this embodiment, the rigid portion Hg can be fixed to the deformable portion Rg and used to fix the adhesive layer 120 and the microneedle layer 130 to prevent the microneedle layer 130 from bending excessively. Likewise, the microneedle layer 130 can be fixed to the fingertip of the corresponding finger of the deformable portion Rg, but other embodiments are not limited to this.

[0066] In summary, in the microneedle patch of the present invention, the second circumferential side of the microneedle layer is flush with or protrudes from the first circumferential side of the adhesive layer, allowing the microneedle layer to completely cover the adhesive layer on the substrate layer. Therefore, when the microneedle layer is inserted into the skin, it effectively separates the adhesive layer from the skin, preventing the adhesive layer from contacting the skin. Based on the above, the microneedle patch of the present invention effectively improves the problem of adhesion to skin and hair during use.

[0067] Although the present invention has been disclosed above by way of embodiments, it is not intended to limit the present invention. Those skilled in the art to which this invention pertains may make some modifications and refinements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A microneedle patch, characterized in that, include: A substrate layer having a surface; An adhesive layer having a first surface and a first surrounding side, the first surface being connected to the first surface and the first surrounding side being positioned on the side of the first surface opposite to the substrate layer. as well as A microneedle layer has a second surface and a second circumferential side, the second surface being connected to the side of the adhesive layer opposite to the substrate layer, and the second circumferential side being positioned on the side of the second surface opposite to the adhesive layer, wherein the second circumferential side is flush with or protrudes from the first circumferential side.

2. The microneedle patch as described in claim 1, characterized in that, The first surrounding side has a first orthographic projection on the surface, and the second surrounding side has a second orthographic projection on the surface, the second orthographic projection overlapping with or surrounding the first orthographic projection.

3. The microneedle patch as described in claim 1, characterized in that, The microneedle layer has a base and a plurality of microneedles. The base has a third surface. The second surface is located on the side of the base that connects to the adhesive layer. The third surface is opposite to the second surface, and the microneedles stand on the third surface. The radius of curvature of the third surface is ≥0.5 cm.

4. The microneedle patch as described in claim 3, characterized in that, It further includes a bending-resistant layer, wherein the bending-resistant layer is disposed between the substrate layer and the adhesive layer, and the hardness of the bending-resistant layer is greater than the hardness of the substrate layer.

5. The microneedle patch as described in claim 4, characterized in that, The material of the flexural layer includes plastic or silicone.

6. The microneedle patch as described in claim 1, characterized in that, The substrate layer is tubular in shape, and the surface includes an outer peripheral surface of the substrate layer.

7. The microneedle patch as described in claim 1, characterized in that, The substrate layer includes a curved plate having a concave surface and a convex surface, the surface including the convex surface.

8. The microneedle patch as described in claim 1, characterized in that, The microneedle layer has a base and a plurality of microneedles. The base has a third surface. The second surface is located on the side of the base that connects to the adhesive layer. The third surface is opposite to the second surface, and the microneedles stand on the third surface. Each of the microneedles has a bottom end and a tip, and the bottom end is connected to the third surface. Each of the microneedles has a length between the bottom end and the tip, and the length is between 100 μm and 1000 μm.

9. The microneedle patch as described in claim 1, characterized in that, The material of the substrate layer includes synthetic polymers, cloth, ceramics, or metals.

10. The microneedle patch as described in claim 1, characterized in that, The adhesive layer can be made of materials such as silicone, acrylic, or hydrogel.

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