A moisturizing and softening lens solution and a method for preparing the same

Abstract

The present application relates to contact lens care technical field, specifically to a kind of moistening soft lens fluid and preparation method thereof, including the following weight parts raw materials: sodium chloride 0.7-0.9 parts, sodium hyaluronate 0.4-0.6 parts, sodium alginate 0.8-1 part, polyhexamethylene biguanide hydrochloride 0.01-0.02 parts, additive 5-6 parts and water for injection 100 parts.In the present application, after the guar gum of additive is treated, it is adsorbed on the contact lens lens to form a firm hydrophilic base, sodium hyaluronate and sodium alginate further lock water molecules on the base, and are interwoven into a dense hydration network layer, extend the water retention period, the lipid carrier of auxiliary protective film is formed on the lens surface by combining the lipid carrier of auxiliary protective film loaded with treasure maple seed oil in auxiliary material, reduce water evaporation loss, powder maintains the chemical homeostasis of moisturizing environment by chelation, synergistically inhibit water loss, improve the moisturizing property of lens fluid.

Description

Technical Field

[0001] This invention relates to the field of contact lens care technology, specifically to a moisturizing and softening eyeglass solution and its preparation method. Background Technology

[0002] Contact lens care solution is a multi-functional chemical solution specifically designed for contact lens care. It removes protein deposits and dirt from the lenses through cleaning ingredients, while using moisturizers to keep the lenses hydrated and supple. It provides one-stop care for cleaning, disinfection, storage, and hydration of the lenses, thereby ensuring the wearer's eye health and comfort.

[0003] In existing technologies, traditional formulas can provide a temporary feeling of moisture, but the moisturizing ingredients do not adhere well to the lens surface, resulting in poor moisturizing effect and dry eyes after prolonged wear. Therefore, this invention provides a moisturizing and smoothing eyeglass solution and its preparation method. Summary of the Invention

[0004] The purpose of this invention is to provide a moisturizing and smoothing eyeglass solution and its preparation method. The eyeglass solution prepared by this invention not only has good moisturizing properties but also excellent smoothing properties, effectively improving the performance of the eyeglass solution.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a moisturizing and smoothing eyeglass solution, comprising the following raw materials in parts by weight: 0.7-0.9 parts sodium chloride, 0.4-0.6 parts sodium hyaluronate, 0.8-1 parts sodium alginate, 0.01-0.02 parts polyhexamethylene biguanide hydrochloride, 5-6 parts additives, 0.1-0.2 parts premix, and 100 parts water for injection; The raw materials for the additives include guar gum, sodium hydroxide solution, 3-chloro-2-hydroxypropyltrimethylammonium chloride, excipients, powders, citric acid, and anhydrous ethanol; The raw materials for the excipients include slurry, medium-chain triglycerides, vitamin E, lecithin, gum arabic, and deionized water; The sodium hyaluronate is selected as a mixture of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate, with a mass ratio of 1:1. The molecular weight of the high molecular weight sodium hyaluronate is 1 million to 2 million Da, and the molecular weight of the low molecular weight sodium hyaluronate is ≤10,000 Da. The premix is ​​a mixture of water-dispersible vitamin E and vitamin B12, with a mass ratio of 1:0.01.

[0006] Furthermore, the additive is prepared by the following method: Step A: Take guar gum powder that has passed through an 80-100 mesh sieve, add sodium hydroxide solution and 3-chloro-2-hydroxypropyltrimethylammonium chloride, and stir for 1-2 hours at 65℃ and 200-300 rpm to obtain a mixture; Step B: Mix the excipients, powder, and mixture, add 25-30 times the weight of deionized water, stir at 200-300 rpm for 2-3 hours, add citric acid, heat to 70-80℃ and continue stirring for 1-2 hours, cool naturally to obtain the cooled product, add anhydrous ethanol, let stand for 3-4 hours, filter to obtain the first solid, wash, and vacuum dry at 45℃ for 16 hours to obtain the additive.

[0007] Further, the sodium hydroxide solution has a mass concentration of 30%, the mass ratio of guar gum powder, sodium hydroxide solution and 3-chloro-2-hydroxypropyltrimethylammonium chloride is 1:(0.1-0.2):(0.8-1.2), the mass ratio of excipients, powder and mixture is 1:(1.5-2.5):(1-1.5), the mass of citric acid is 5-10% of the mass of excipients, and the mass of anhydrous ethanol is 4 times the mass of the cooled product.

[0008] Further, the powder is prepared by the following method: glucose powder and oleyl alcohol are mixed at a mass ratio of 1:(3-5), stirred at 150-250 rpm for 15-20 min, 1-2% of the glucose powder mass of the additive is added, and the mixture is stirred at 100-120℃, 150-200 rpm, and -0.08 MPa for 3-5 h, naturally cooled, pH adjusted to neutral, filtered to obtain the first filtrate, 1-3% of the first filtrate mass of hydrogen peroxide solution is added, and the mixture is stirred at 70-80℃ and 100-200 rpm for 40-60 min, and spray-dried at an inlet temperature of 150-170℃ and an outlet temperature of 70-90℃ to obtain the powder, wherein the mass concentration of the hydrogen peroxide solution is 30-40%.

[0009] Further, the additive is prepared by the following method: ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate and deionized water are mixed and stirred at 60°C and 100-200 rpm for 20-30 min, phosphoric acid is added, stirring is continued for 1-2 h, and the mixture is concentrated to 1 / 2 of its original volume at 40-50°C and -0.09 MPa to obtain the additive.

[0010] Furthermore, the mass ratio of ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate, deionized water and phosphoric acid is 1:(3-5):(12-14):(7-9).

[0011] Furthermore, the excipients are prepared by the following method: Step 1: Mix the slurry, medium-chain triglycerides, vitamin E and lecithin in a mass ratio of 1:(1-2):(0.05-0.1):(0.02-0.05), and stir for 20-30 minutes at 45-55℃ and 100-150 rpm to obtain the first solution; Step 2: Mix gum arabic and deionized water at a mass ratio of 1:(20-30), and stir at 100-200 rpm for 10-15 min to obtain the second solution; Step 3: Mix the first solution and the second solution at a mass ratio of 1:(5-8), stir at 300-500 rpm for 30-40 min, and spray dry at an inlet temperature of 140-150℃ and an outlet temperature of 70-80℃ to obtain the excipient.

[0012] Further, the slurry is prepared by the following method: Acer truncatum seed oil is mixed with anhydrous ethanol, lipase is added, and the mixture is stirred at 40-50℃ and 100-150 rpm for 8 hours. The resulting product is centrifuged at 3000-4000 rpm for 5-10 minutes, and the supernatant is collected. The supernatant and urea are mixed at a mass ratio of 1:(3-5) and stirred at 60-70℃ and 200-300 rpm for 20-30 minutes. The mixture is then cooled to 0℃ and allowed to stand for 8-12 hours. After filtration, a second filtrate is obtained and concentrated to 1 / 10 of the original volume at 50℃ and -0.06 MPa to obtain the slurry.

[0013] Furthermore, the mass ratio of the Acer truncatum seed oil to anhydrous ethanol is 1:(3-5), and the mass of the lipase is 5-10% of the mass of the Acer truncatum seed oil.

[0014] Furthermore, the preparation method of the moisturizing and smoothing eyeglass solution includes the following steps: weigh water for injection as needed, heat to 40-50℃, add sodium chloride, stir at 40-50℃ and 200-300 rpm for 5-10 min, add sodium hyaluronate and sodium alginate, stir at 200-300 rpm for 40-60 min, add polyhexamethylene biguanide hydrochloride and continue stirring for 10-20 min, add additives, adjust the speed to 300-500 rpm and stir for 1-2 h, add a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, adjust the pH to neutral, the mass ratio of sodium dihydrogen phosphate to disodium hydrogen phosphate is 1.2:(0.5-0.7), filter to obtain the third filtrate, and obtain the moisturizing and smoothing eyeglass solution.

[0015] Compared with the prior art, the beneficial effects of the present invention are: 1. In this invention, the guar gum in the additives, after treatment, adsorbs onto the contact lens to form a firmly anchored hydrophilic substrate. Sodium hyaluronate and sodium alginate further lock in water molecules on the substrate, intertwining to form a dense hydration network layer, extending the moisture retention period. Combined with the lipid carrier loaded with Acer truncatum seed oil in the excipients, it forms an auxiliary protective film on the lens surface, reducing moisture evaporation loss. The antioxidant additive in the powder, which is compounded with ethylenediaminetetraacetic acid and sodium dodecylbenzenesulfonate, maintains the chemical homeostasis of the moisturizing environment through chelation, and works synergistically with the lipid protective film to inhibit moisture loss, reduce the lens dehydration rate, and improve the moisturizing properties of the eyeglass solution.

[0016] 2. In this invention, the modified guar gum in the additives forms a strong hydration layer on the lens surface, significantly reducing relative motion resistance. The Acer truncatum seed oil and vitamin E, loaded with lipid encapsulation technology in the excipients, slowly release lipid components during wear, forming a lubricating layer on the surface of the hydration layer. Furthermore, the antioxidant effect of vitamin E protects the lubricating layer from oxidative damage. The powder, through chelation, removes metal ions that disrupt the stability of the lubricating layer in the system, improving the smoothness of the eyeglass solution. The combined use of high-molecular-weight and low-molecular-weight sodium hyaluronate, with the low-molecular-weight sodium hyaluronate having strong permeability and able to penetrate deep into the interstitial spaces of the mucous membrane to replenish moisture from within and improve deep dryness, and the high-molecular-weight sodium hyaluronate... Sodium hyaluronate can form a smooth water film on the surface, reducing friction and preventing moisture evaporation. The two work together to provide complementary moisturizing effects, effectively enhancing the moisturizing performance of the eyeglass solution. Vitamin E, as a fat-soluble antioxidant, can effectively remove free radicals, protect ocular surface cells from oxidative damage, and delay the product's own oxidative deterioration. Vitamin B12 can promote the metabolism, proliferation, and repair of ocular surface cells such as corneal epithelial cells, helping to maintain ocular surface health and improving the comfort of using the eyeglass solution. In addition, after removing the lenses, the eyeglass solution can be poured onto your hands and rubbed together before use. The low molecular weight sodium hyaluronate can penetrate into the skin, enhancing skin hydration, and creating a fragrant moisturizing effect on the hands. Attached Figure Description

[0017] Figure 1 The present invention provides a flowchart of a moisturizing and smoothing eyeglass solution and its preparation method. Detailed Implementation

[0018] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0019] It should be noted that the raw materials used in the following embodiments are all commercially available. Example 1:

[0020] A moisturizing and smoothing eyeglass solution comprises the following raw materials in parts by weight: 0.7 parts sodium chloride, 0.4 parts sodium hyaluronate, 0.8 parts sodium alginate, 0.01 parts polyhexamethylene biguanide hydrochloride, 5 parts additives, 0.1 parts premix, and 100 parts water for injection; The raw materials for the additives include guar gum, sodium hydroxide solution, 3-chloro-2-hydroxypropyltrimethylammonium chloride, excipients, powders, citric acid, and anhydrous ethanol; The raw materials for the excipients include slurry, medium-chain triglycerides, vitamin E, lecithin, gum arabic, and deionized water; The sodium hyaluronate is selected as a mixture of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate, with a mass ratio of 1:1. The molecular weight of the high molecular weight sodium hyaluronate is 1 million Da, and the molecular weight of the low molecular weight sodium hyaluronate is 2000 Da. The premix is ​​a mixture of water-dispersible vitamin E and vitamin B12, with a mass ratio of water-dispersible vitamin E to vitamin B12 of 1:0.01. The additives are prepared by the following methods: Step A: Take guar gum powder that has passed through an 80-mesh sieve, mix guar gum powder, sodium hydroxide solution, and 3-chloro-2-hydroxypropyltrimethylammonium chloride at a mass ratio of 1:0.1:0.8, and stir for 1 hour at 65°C and 200 rpm to obtain a mixture, wherein the mass concentration of sodium hydroxide solution is 30%. Step B: Mix the excipients, powder, and mixture at a mass ratio of 1:1.5:1, add 25 times the mass of deionized water, stir at 200 rpm for 2 hours, add 5% citric acid (by mass of the excipients), heat to 70℃ and continue stirring for 1 hour, allow to cool naturally to obtain the cooled product, add 4 times the mass of anhydrous ethanol, let stand for 3 hours, filter to obtain the first solid, wash, and vacuum dry at 45℃ for 16 hours to obtain the additive.

[0021] The powder was prepared by the following method: glucose powder and oleyl alcohol were mixed at a mass ratio of 1:3 and stirred at 150 rpm for 15 min. An auxiliary agent of 1% by mass of glucose powder was added and mixed at 100℃, 150 rpm and -0.08 MPa for 3 h. After natural cooling, the pH was adjusted to neutral and filtered to obtain the first filtrate. Hydrogen peroxide solution of 1% by mass of the first filtrate was added and stirred at 70℃ and 100 rpm for 40 min. The powder was obtained by spray drying at an inlet temperature of 150℃ and an outlet temperature of 70℃. The mass concentration of hydrogen peroxide solution was 30%.

[0022] The additive was prepared by the following method: ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate and deionized water were mixed and stirred at 60℃ and 100rpm for 20min. Phosphoric acid was added and stirring was continued for 1h. The mixture was then concentrated to half its original volume at 40℃ and -0.09MPa to obtain the additive. The mass ratio of ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate, deionized water and phosphoric acid was 1:3:12:7.

[0023] The excipients are prepared by the following methods: Step 1: Mix the slurry, medium-chain triglycerides, vitamin E and lecithin in a mass ratio of 1:1:0.05:0.02, and stir at 45℃ and 100rpm for 20 minutes to obtain the first solution; Step 2: Mix gum arabic and deionized water at a mass ratio of 1:20 and stir at 100 rpm for 10 min to obtain the second solution; Step 3: Mix the first solution and the second solution at a mass ratio of 1:5, stir at 300 rpm for 30 min, and spray dry at an inlet temperature of 140℃ and an outlet temperature of 70℃ to obtain the excipient.

[0024] The slurry was prepared by the following method: Acer truncatum seed oil and anhydrous ethanol were mixed at a mass ratio of 1:3, and lipase at 5% of the mass of Acer truncatum seed oil was added. The mixture was stirred at 40℃ and 100 rpm for 8 hours. The resulting product was centrifuged at 3000 rpm for 5 minutes, and the supernatant was collected. The supernatant and urea were mixed at a mass ratio of 1:3 and stirred at 60℃ and 200 rpm for 20 minutes. The mixture was cooled to 0℃ and allowed to stand for 8 hours. The mixture was filtered to obtain the second filtrate, which was concentrated to 1 / 10 of the original volume at 50℃ and -0.06 MPa to obtain the slurry.

[0025] The preparation method of the moisturizing and smoothing eyeglass solution includes the following steps: Weigh the required amount of water for injection, heat it to 40°C, add sodium chloride, stir at 40°C and 200 rpm for 5 min, add sodium hyaluronate and sodium alginate, stir at 200 rpm for 40 min, add polyhexamethylene biguanide hydrochloride and continue stirring for 10 min, add the additives, adjust the speed to 300 rpm and stir for 1 h, then add a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, adjust the pH to neutral, the mass ratio of sodium dihydrogen phosphate to disodium hydrogen phosphate is 1.2:0.5, filter to obtain the third filtrate, and obtain the moisturizing and smoothing eyeglass solution. Example 2:

[0026] A moisturizing and smoothing eyeglass solution comprises the following raw materials in parts by weight: 0.8 parts sodium chloride, 0.5 parts sodium hyaluronate, 0.9 parts sodium alginate, 0.015 parts polyhexamethylene biguanide hydrochloride, 5.5 parts additives, 0.15 parts premix, and 100 parts water for injection; The raw materials for the additives include guar gum, sodium hydroxide solution, 3-chloro-2-hydroxypropyltrimethylammonium chloride, excipients, powders, citric acid, and anhydrous ethanol; The raw materials for the excipients include slurry, medium-chain triglycerides, vitamin E, lecithin, gum arabic, and deionized water; The sodium hyaluronate is selected as a mixture of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate, with a mass ratio of 1:1. The molecular weight of the high molecular weight sodium hyaluronate is 1.5 million Da, and the molecular weight of the low molecular weight sodium hyaluronate is 3,000 Da. The premix is ​​a mixture of water-dispersible vitamin E and vitamin B12, with a mass ratio of water-dispersible vitamin E to vitamin B12 of 1:0.01. The additives are prepared by the following methods: Step A: Take guar gum powder that has passed through a 90-mesh sieve, mix guar gum powder, sodium hydroxide solution, and 3-chloro-2-hydroxypropyltrimethylammonium chloride at a mass ratio of 1:0.15:1, and stir at 65℃ and 250 rpm for 1.5 h to obtain a mixture, wherein the mass concentration of sodium hydroxide solution is 30%. Step B: Mix the excipients, powder, and mixture in a mass ratio of 1:2:1.3, add 27 times the mass of deionized water, stir at 250 rpm for 2.5 h, add 7% citric acid (by mass of the excipients), heat to 75℃ and continue stirring for 1.5 h, allow to cool naturally to obtain the cooled product, add 4 times the mass of anhydrous ethanol, let stand for 3.5 h, filter to obtain the first solid, wash, and vacuum dry at 45℃ for 16 h to obtain the additive.

[0027] The powder was prepared by the following method: glucose powder and oleyl alcohol were mixed at a mass ratio of 1:4 and stirred at 200 rpm for 17 min. 1.5% of the glucose powder mass of an auxiliary agent was added, and the mixture was stirred at 110℃, 170 rpm, and -0.08 MPa for 4 h. After natural cooling, the pH was adjusted to neutral, and the mixture was filtered to obtain the first filtrate. 2% of the first filtrate mass of hydrogen peroxide solution was added, and the mixture was stirred at 75℃ and 150 rpm for 50 min. The powder was obtained by spray drying at an inlet temperature of 160℃ and an outlet temperature of 80℃. The mass concentration of the hydrogen peroxide solution was 35%.

[0028] The additive was prepared by the following method: ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate and deionized water were mixed and stirred at 60℃ and 150 rpm for 25 min. Phosphoric acid was added and stirring was continued for 1.5 h. The mixture was then concentrated to half its original volume at 45℃ and -0.09 MPa to obtain the additive. The mass ratio of ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate, deionized water and phosphoric acid was 1:4:13:8.

[0029] The excipients are prepared by the following methods: Step 1: Mix the slurry, medium-chain triglycerides, vitamin E and lecithin in a mass ratio of 1:1.5:0.07:0.03, and stir at 50℃ and 125rpm for 25 minutes to obtain the first solution; Step 2: Mix gum arabic and deionized water at a mass ratio of 1:25 and stir at 150 rpm for 12 minutes to obtain the second solution; Step 3: Mix the first solution and the second solution at a mass ratio of 1:7, stir at 400 rpm for 35 min, and spray dry at an inlet temperature of 145℃ and an outlet temperature of 75℃ to obtain the excipient.

[0030] The slurry was prepared by the following method: Acer truncatum seed oil and anhydrous ethanol were mixed at a mass ratio of 1:4, and lipase at 7% of the mass of Acer truncatum seed oil was added. The mixture was stirred at 45℃ and 125 rpm for 8 hours. The resulting product was centrifuged at 3500 rpm for 7 minutes, and the supernatant was collected. The supernatant and urea were mixed at a mass ratio of 1:4 and stirred at 65℃ and 250 rpm for 25 minutes. The mixture was cooled to 0℃ and allowed to stand for 10 hours. The mixture was filtered to obtain the second filtrate, which was concentrated to 1 / 10 of the original volume at 50℃ and -0.06 MPa to obtain the slurry.

[0031] The preparation method of the moisturizing and smoothing eyeglass solution includes the following steps: Weigh out water for injection as needed, heat to 45°C, add sodium chloride, stir at 45°C and 250 rpm for 7 min, add sodium hyaluronate and sodium alginate, stir at 250 rpm for 50 min, add polyhexamethylene biguanide hydrochloride and continue stirring for 15 min, add additives, adjust the speed to 400 rpm and stir for 1.5 h, add a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, adjust the pH to neutral, the mass ratio of sodium dihydrogen phosphate to disodium hydrogen phosphate is 1.2:0.6, filter to obtain the third filtrate, and obtain the moisturizing and smoothing eyeglass solution. Example 3:

[0032] A moisturizing and smoothing eyeglass solution comprises the following raw materials in parts by weight: 0.9 parts sodium chloride, 0.6 parts sodium hyaluronate, 1 part sodium alginate, 0.02 parts polyhexamethylene biguanide hydrochloride, 6 parts additives, 0.2 parts premix, and 100 parts water for injection; The raw materials for the additives include guar gum, sodium hydroxide solution, 3-chloro-2-hydroxypropyltrimethylammonium chloride, excipients, powders, citric acid, and anhydrous ethanol; The raw materials for the excipients include slurry, medium-chain triglycerides, vitamin E, lecithin, gum arabic, and deionized water; The sodium hyaluronate is selected as a mixture of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate, with a mass ratio of 1:1. The molecular weight of the high molecular weight sodium hyaluronate is 2 million Da, and the molecular weight of the low molecular weight sodium hyaluronate is 5,000 Da. The premix is ​​a mixture of water-dispersible vitamin E and vitamin B12, with a mass ratio of water-dispersible vitamin E to vitamin B12 of 1:0.01. The additives are prepared by the following methods: Step A: Take guar gum powder that has passed through a 100-mesh sieve, mix guar gum powder, sodium hydroxide solution, and 3-chloro-2-hydroxypropyltrimethylammonium chloride at a mass ratio of 1:0.2:1.2, and stir at 65℃ and 300 rpm for 2 hours to obtain a mixture, wherein the mass concentration of sodium hydroxide solution is 30%. Step B: Mix the excipients, powder, and mixture in a mass ratio of 1:2.5:1.5, add 30 times the mass of deionized water, stir at 300 rpm for 3 hours, add 10% citric acid (by mass of the excipients), heat to 80℃ and continue stirring for 2 hours, allow to cool naturally to obtain the cooled product, add 4 times the mass of anhydrous ethanol, let stand for 4 hours, filter to obtain the first solid, wash, and vacuum dry at 45℃ for 16 hours to obtain the additive.

[0033] The powder was prepared by the following method: glucose powder and oleyl alcohol were mixed at a mass ratio of 1:5 and stirred at 250 rpm for 20 min. 2% of the glucose powder mass of an auxiliary agent was added, and the mixture was stirred at 120℃, 200 rpm, and -0.08 MPa for 5 h. After natural cooling, the pH was adjusted to neutral, and the mixture was filtered to obtain the first filtrate. 3% of the first filtrate mass of hydrogen peroxide solution was added, and the mixture was stirred at 80℃ and 200 rpm for 60 min. The powder was obtained by spray drying at an inlet temperature of 170℃ and an outlet temperature of 90℃. The mass concentration of the hydrogen peroxide solution was 40%.

[0034] The additive was prepared by the following method: ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate and deionized water were mixed and stirred at 60℃ and 200 rpm for 30 min. Phosphoric acid was added and stirring was continued for 2 h. The mixture was then concentrated to half its original volume at 50℃ and -0.09 MPa to obtain the additive. The mass ratio of ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate, deionized water and phosphoric acid was 1:5:14:9.

[0035] The excipients are prepared by the following methods: Step 1: Mix the slurry, medium-chain triglycerides, vitamin E and lecithin in a mass ratio of 1:2:0.1:0.05, and stir at 55℃ and 150rpm for 30 minutes to obtain the first solution; Step 2: Mix gum arabic and deionized water at a mass ratio of 1:30 and stir at 200 rpm for 15 min to obtain the second solution; Step 3: Mix the first solution and the second solution at a mass ratio of 1:8, stir at 500 rpm for 40 min, and spray dry at an inlet temperature of 150℃ and an outlet temperature of 80℃ to obtain the excipient.

[0036] The slurry was prepared by the following method: Acer truncatum seed oil and anhydrous ethanol were mixed at a mass ratio of 1:5, and lipase at 10% of the mass of Acer truncatum seed oil was added. The mixture was stirred at 50℃ and 150 rpm for 8 hours. The resulting product was centrifuged at 4000 rpm for 10 minutes, and the supernatant was collected. The supernatant and urea were mixed at a mass ratio of 1:5 and stirred at 70℃ and 300 rpm for 30 minutes. The mixture was cooled to 0℃ and allowed to stand for 12 hours. The mixture was filtered to obtain the second filtrate, which was concentrated to 1 / 10 of the original volume at 50℃ and -0.06 MPa to obtain the slurry.

[0037] The preparation method of the moisturizing and smoothing eyeglass solution includes the following steps: Weigh out water for injection as needed, heat to 50°C, add sodium chloride, stir at 50°C and 300 rpm for 10 min, add sodium hyaluronate and sodium alginate, stir at 300 rpm for 60 min, add polyhexamethylene biguanide hydrochloride and continue stirring for 20 min, add additives, adjust the speed to 500 rpm and stir for 2 h, then add a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, adjust the pH to neutral, the mass ratio of sodium dihydrogen phosphate to disodium hydrogen phosphate is 1.2:0.7, filter to obtain the third filtrate, and obtain the moisturizing and smoothing eyeglass solution.

[0038] Comparative Example 1: The difference between this comparative example and Example 1 is that this comparative example does not contain any additives.

[0039] Comparative Example 2 differs from Example 1 in that it does not contain any excipients.

[0040] Comparative Example 3 differs from Example 1 in that it does not contain powder.

[0041] Performance testing: The performance of the eyeglass solutions treated in Examples 1-3 and Comparative Examples 1-3 was tested, and the test data are recorded in the table below: Table 1

[0042] In the performance test, the moisturizing performance was tested based on the moisturizing time. In an environment of 30℃ and 50%RH, 3 drops of eyeglass solution were added to the surface of the contact lens, and the moisturizing time was tested. The longer the time, the better the moisturizing performance. The smoothness performance was tested based on the coefficient of friction. The coefficient of friction was determined by the four-ball method of GB / T3142-2019. The coefficient of friction was determined by a four-ball tribometer. The friction system load was 30N, the diameter of the ceramic ball was 12.7mm, the rotation speed was 1500rpm, the temperature was 37℃, and the test time was 30min. The lower the coefficient of friction, the better the smoothness.

[0043] By comparing and analyzing the relevant data in the table, it can be seen that the moisturizing and softening eyeglass solution processed by this invention not only has good moisturizing properties but also excellent softening properties. This indicates that the moisturizing and softening eyeglass solution provided by this invention has a broader market prospect and is more suitable for promotion.

[0044] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0045] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A moisturizing and smoothing eyeglass solution, characterized in that, The ingredients include the following parts by weight: sodium chloride 0.7-0.9 parts, sodium hyaluronate 0.4-0.6 parts, sodium alginate 0.8-1 parts, polyhexamethylene biguanide hydrochloride 0.01-0.02 parts, additives 5-6 parts, premix 0.1-0.2 parts, and water for injection 100 parts; The raw materials for the additives include guar gum, sodium hydroxide solution, 3-chloro-2-hydroxypropyltrimethylammonium chloride, excipients, powders, citric acid, and anhydrous ethanol; The raw materials for the excipients include slurry, medium-chain triglycerides, vitamin E, lecithin, gum arabic, and deionized water; The sodium hyaluronate is selected as a mixture of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate, with a mass ratio of 1:

1. The molecular weight of the high molecular weight sodium hyaluronate is 1 million to 2 million Da, and the molecular weight of the low molecular weight sodium hyaluronate is ≤10,000 Da. The premix is ​​a mixture of water-dispersible vitamin E and vitamin B12, with a mass ratio of 1:0.

01.

2. The moisturizing and softening eyeglass solution according to claim 1, characterized in that, The additive is prepared by the following method: Step A: Take guar gum powder that has passed through an 80-100 mesh sieve, add sodium hydroxide solution and 3-chloro-2-hydroxypropyltrimethylammonium chloride, and stir for 1-2 hours at 65℃ and 200-300 rpm to obtain a mixture; Step B: Mix the excipients, powder, and mixture, add 25-30 times the weight of deionized water, stir at 200-300 rpm for 2-3 hours, add citric acid, heat to 70-80℃ and continue stirring for 1-2 hours, cool naturally to obtain the cooled product, add anhydrous ethanol, let stand for 3-4 hours, filter to obtain the first solid, wash, and vacuum dry at 45℃ for 16 hours to obtain the additive.

3. The moisturizing and softening eyeglass solution according to claim 2, characterized in that, The sodium hydroxide solution has a mass concentration of 30%, the mass ratio of guar gum powder, sodium hydroxide solution and 3-chloro-2-hydroxypropyltrimethylammonium chloride is 1:(0.1-0.2):(0.8-1.2), the mass ratio of excipients, powder and mixture is 1:(1.5-2.5):(1-1.5), the mass of citric acid is 5-10% of the mass of excipients, and the mass of anhydrous ethanol is 4 times the mass of the cooled product.

4. The moisturizing and softening eyeglass solution according to claim 1, characterized in that, The powder is prepared by the following method: glucose powder and oleyl alcohol are mixed at a mass ratio of 1:(3-5), stirred at 150-250 rpm for 15-20 min, 1-2% of the glucose powder mass of the additive is added, and the mixture is stirred at 100-120℃, 150-200 rpm, and -0.08 MPa for 3-5 h, naturally cooled, pH adjusted to neutral, filtered to obtain the first filtrate, 1-3% of the first filtrate mass of hydrogen peroxide solution is added, and the mixture is stirred at 70-80℃ and 100-200 rpm for 40-60 min, and spray-dried at an inlet temperature of 150-170℃ and an outlet temperature of 70-90℃ to obtain the powder, wherein the mass concentration of the hydrogen peroxide solution is 30-40%.

5. The moisturizing and softening eyeglass solution according to claim 4, characterized in that, The additive is prepared by the following method: ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate and deionized water are mixed and stirred at 60°C and 100-200 rpm for 20-30 min. Phosphoric acid is added and stirring is continued for 1-2 h. The mixture is then concentrated to half its original volume at 40-50°C and -0.09 MPa to obtain the additive.

6. The moisturizing and softening eyeglass solution according to claim 5, characterized in that, The mass ratio of ethylenediaminetetraacetic acid, sodium dodecylbenzenesulfonate, deionized water and phosphoric acid is 1:(3-5):(12-14):(7-9).

7. The moisturizing and softening eyeglass solution according to claim 1, characterized in that, The excipients are prepared by the following method: Step 1: Mix the slurry, medium-chain triglycerides, vitamin E and lecithin in a mass ratio of 1:(1-2):(0.05-0.1):(0.02-0.05), and stir for 20-30 minutes at 45-55℃ and 100-150 rpm to obtain the first solution; Step 2: Mix gum arabic and deionized water at a mass ratio of 1:(20-30), and stir at 100-200 rpm for 10-15 min to obtain the second solution; Step 3: Mix the first solution and the second solution at a mass ratio of 1:(5-8), stir at 300-500 rpm for 30-40 min, and spray dry at an inlet temperature of 140-150℃ and an outlet temperature of 70-80℃ to obtain the excipient.

8. The moisturizing and softening eyeglass solution according to claim 7, characterized in that, The slurry was prepared by the following method: Acer truncatum seed oil was mixed with anhydrous ethanol, lipase was added, and the mixture was stirred at 40-50℃ and 100-150 rpm for 8 hours. The product was centrifuged at 3000-4000 rpm for 5-10 minutes, and the supernatant was collected. The supernatant and urea were mixed at a mass ratio of 1:(3-5) and stirred at 60-70℃ and 200-300 rpm for 20-30 minutes. The mixture was cooled to 0℃ and allowed to stand for 8-12 hours. The mixture was filtered to obtain a second filtrate, which was concentrated to 1 / 10 of its original volume at 50℃ and -0.06 MPa to obtain the slurry.

9. The moisturizing and softening eyeglass solution according to claim 8, characterized in that, The mass ratio of Acer truncatum seed oil to anhydrous ethanol is 1:(3-5), and the mass of lipase is 5-10% of the mass of Acer truncatum seed oil.

10. The method for preparing the moisturizing and softening eyeglass solution according to any one of claims 1-9, characterized in that, The process includes the following steps: Weigh out water for injection as needed, heat to 40-50℃, add sodium chloride, and stir at 40-50℃ and 200-300 rpm for 5-10 minutes. Add sodium hyaluronate and sodium alginate, and stir at 200-300 rpm for 40-60 minutes. Add polyhexamethylene biguanide hydrochloride and continue stirring for 10-20 minutes. Add additives, adjust the stirring speed to 300-500 rpm, and stir for 1-2 hours. Add a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, adjust the pH to neutral, and the mass ratio of sodium dihydrogen phosphate to disodium hydrogen phosphate is 1.2:(0.5-0.7). Filter to obtain the third filtrate, thus preparing a moisturizing and smoothing eyeglass solution.

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