Baijiu vinasse enzymatic polypeptide, preparation method and application thereof

By combining alcohol-alkali extraction and alkaline proteolysis with ultrafiltration dialysis technology, and optimizing the enzymatic hydrolysis conditions, enzymatically hydrolyzed peptides from baijiu lees with the effect of preventing alcoholic liver damage were prepared. This solved the problems of low utilization rate and high pollution of baijiu lees in the existing technology, and realized the efficient utilization of baijiu lees and the preparation of bioactive peptides.

CN122428012APending Publication Date: 2026-07-21SHAANXI UNIV OF SCI & TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHAANXI UNIV OF SCI & TECH
Filing Date
2026-06-05
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

Existing research on polypeptides from baijiu lees mainly focuses on functions such as anti-oxidation and blood pressure reduction. However, there is a lack of optimization in the targeted enzymatic hydrolysis preparation process for preventing alcoholic liver damage. The structure-activity relationship and mechanism of action of active substances are unclear, resulting in low utilization rate and high pollution of baijiu lees.

Method used

The protein in baijiu lees was extracted using the alcohol-alkali method. Combined with alkaline protease hydrolysis, ultrafiltration, and dialysis techniques, and with optimized hydrolysis conditions, enzymatically hydrolyzed polypeptides from baijiu lees with the effect of preventing alcoholic liver damage were prepared.

Benefits of technology

The prepared enzymatically hydrolyzed polypeptides from baijiu lees maintain their biological activity during enzymatic hydrolysis, significantly reduce intracellular ALT and AST leakage, and have a significant effect in preventing alcoholic liver damage. They are suitable for food and health products.

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Abstract

The present application belongs to the technical field of active peptide preparation, and relates to a kind of liquor vinasse zymohydrolysis polypeptide and its preparation method and application, and the zymolysis process condition of the preparation method is as follows: in the buffer system of pH 8.0, with the addition amount of alkaline protease 3%, reaction temperature 40 DEG C, zymolysis time 180 min, substrate concentration 6% to the zymolysis of liquor vinasse alcohol soluble protein, and the zymolysis product is prepared by ultrafiltration. By constructing HepG2 cell alcoholic fatty liver model verification, alcoholic liver injury can be obviously relieved. The peptide is suitable for the development of functional food and health products, and provides a low-toxicity, green and sustainable liver protection solution.
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Citation Information

Patent Citations

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  • Method for preparing active peptide from waste fermented grains

    CN106520878A