Solid pharmaceutical formulations for peritoneal dialysis and methods for their production
By using multi-layered particles or 3D-printed solid drug formulations, the high operating costs and stability issues of peritoneal dialysis solutions have been resolved, achieving stability and uniformity, reducing storage space requirements, and improving patient convenience and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- WYITE US HEALTHCARE LLC
- Filing Date
- 2024-12-23
- Publication Date
- 2026-07-21
AI Technical Summary
Current peritoneal dialysis solutions are provided in solution form, which results in high operating costs, large storage space requirements, inconvenience for patients, and difficulty in personalization. Furthermore, existing solid drug formulations present challenges in terms of component stability and homogeneity, especially the potential for reaction between sodium bicarbonate and electrolytes.
Solid pharmaceutical formulations using multi-layered particles or 3D printing include sodium chloride nucleating particles coated with sodium bicarbonate, glucose, calcium chloride, magnesium chloride, and a sodium lactate layer. This avoids the use of sodium acetate and organic acids, prevents sodium bicarbonate from reacting with electrolytes, and is produced using fluidized bed granulation and 3D printing technologies.
It achieves stability and uniformity, reduces operating costs, decreases storage space requirements, improves patient convenience and safety, and avoids the drawbacks of traditional solution forms.
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