A holographic moxibustion composition, its preparation method and application

Abstract

This invention belongs to the technical field of traditional Chinese medicine physiotherapy products, specifically relating to a holographic moxibustion composition, its preparation method, and its application. The composition comprises the following raw materials in parts by weight: 10-20 parts of a thermosensitive piezoelectric carrier, 60-70 parts of a graded carbonized base material, and 4-16 parts of an active embedding material; the loading of the active embedding material relative to the total mass of the thermosensitive piezoelectric carrier and the graded carbonized base material is 5%-20%, and the weight ratio of the traditional Chinese medicine extract to the graded carbonized base material is 1:5-1:15. This invention uses tourmaline modified with an organosilane coupling agent as a thermosensitive piezoelectric carrier, combined with a bimodal microporous moxa charcoal base material formed by gradient temperature-controlled carbonization, and is prepared through carrier modification, graded carbonization, negative pressure drug loading, and molding. This invention utilizes the synergistic function of each component to improve energy conduction and drug binding performance. The preparation process is simple and controllable, and it can be made into various moxibustion dosage forms, suitable for traditional Chinese medicine holographic site physiotherapy and daily health care external products.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine physiotherapy products technology, specifically relating to a holographic moxibustion composition, its preparation method, and its application. Background Technology

[0002] Moxibustion, as a traditional external treatment method in Traditional Chinese Medicine (TCM), is widely used in TCM meridian theory and holographic theory. Holographic theory posits that local areas of the human body contain information about the whole, and that stimulating holographic sites can regulate overall function. However, existing moxibustion products still have limitations in practical application: First, their energy penetration is weak; traditional moxibustion heat mostly stops at the epidermis, making it difficult to penetrate the skin barrier to reach deep holographic reflex zones. Second, they lack a driving force for efficacy; during moxibustion, active ingredients are mostly passively adsorbed, lacking an active transdermal driving mechanism. Third, their energy conversion rate is low; existing materials exhibit passive physical activity within the temperature control range of moxibustion, making it difficult to generate microcurrents that resonate with the body's bioelectric frequency. Fourth, their structural stability is poor; the active ingredients of medicinal materials are not firmly bound to inorganic carriers, and they easily volatilize too quickly when heated. Therefore, developing a holographic moxibustion composition with multi-level energy conversion, high-efficiency transdermal enhancement, and structural stability is a pressing technical problem to be solved in the field of TCM physiotherapy. Summary of the Invention

[0003] In view of the above-mentioned shortcomings in the prior art, the present invention provides a holographic moxibustion composition, its preparation method and application, so as to solve the problems in the background art.

[0004] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: A holographic moxibustion composition comprising the following raw materials in parts by weight: 10–20 parts of thermistor piezoelectric carrier; 60–70 parts of graded carbonized matrix; 4–16 parts of active encapsulant; Furthermore, the thermal piezoelectric carrier is surface-modified tourmaline powder, and the surface modification method is to form an oleophilic coating layer on the surface of the tourmaline powder using an organosilane coupling agent; Furthermore, the graded carbonized base material is semi-carbonized artemisia powder with a porous structure, and its micropore size exhibits a bimodal distribution. Furthermore, the active encapsulant is a traditional Chinese medicine extract, and the active encapsulant is loaded within the micropores of the graded carbonized matrix and on the surface of the thermosensitive piezoelectric carrier.

[0005] Furthermore, the average particle size of the thermosensitive piezoelectric carrier is 5μm–15μm; the bimodal micropore sizes of the graded carbonized matrix are 10–30nm and 80–120nm, respectively.

[0006] Furthermore, the organosilane coupling agent is selected from at least one of γ-aminopropyltriethoxysilane, γ-glycidoxypropyltrimethoxysilane, and γ-methacryloyloxypropyltrimethoxysilane.

[0007] Furthermore, the raw materials for the herbal extract are selected from one or more of the following: Artemisia argyi, Angelica sinensis, dried ginger, Clematis chinensis, and Lycopodium clavatum.

[0008] Furthermore, the loading of the active encapsulant relative to the total mass of the thermosensitive piezoelectric carrier and the graded carbonized matrix is ​​5%–20%.

[0009] A method for preparing the holographic moxibustion composition as described above includes the following steps: S1. Place tourmaline powder in an organosilane coupling agent solution, stir at 60–80°C for 1–3 hours, and dry to obtain a thermosensitive piezoelectric carrier. S2. Artemisia argyi floss is subjected to a gradient heating treatment of 200–330℃ in an anaerobic environment to obtain a graded carbonized base material with bimodal pore size. S3. After dissolving the Chinese herbal extract, mix it with the thermosensitive piezoelectric carrier and graded carbonized base material, and then filter it under reduced pressure or under high pressure permeation loading. S4. After mixing evenly, press and shape to obtain the holographic moxibustion composition.

[0010] Further, in step S1, the weight ratio of the organosilane coupling agent to the tourmaline powder is 1:50–1:200.

[0011] Further, in step S3, the weight ratio of the traditional Chinese medicine extract to the graded carbonized base material is 1:5–1:15.

[0012] Further, in step S2, the gradient heating is to first hold at 220–250°C for 30–60 minutes, and then raise the temperature to 300–330°C and hold for 20–40 minutes.

[0013] As mentioned above, the holographic moxibustion composition is used in the preparation of daily health care and physiotherapy products, or non-medical physiotherapy products with transdermal synergistic properties.

[0014] Compared with the prior art, the present invention has the following beneficial effects: 1. By introducing a modified thermosensitive piezoelectric carrier, microcurrents are generated through the piezoelectric effect within the application temperature control range. This thermo-induced electric field can couple with the stratum corneum of the skin, reduce the density of the skin barrier, and provide a directional transdermal driving force for the active ingredients of traditional Chinese medicine. Combined with the infrared radiation effect of the carbonized base material, the heat energy transfer is no longer limited to the superficial layer of the skin, effectively improving the penetration depth of energy into the subcutaneous tissue. 2. The bimodal microporous structure of the carbonized base material significantly increases the adsorption capacity for traditional Chinese medicine extracts; small-sized micropores enable long-term locking and sustained release of active ingredients, while large-sized micropores ensure rapid onset of action in the initial stage, forming a graded drug release synergistic mechanism; at the same time, the physical field formed by the piezoelectric material can drive the active ingredients of the drug, significantly improving the transdermal penetration rate of the active ingredients compared with traditional moxibustion materials. 3. The modification of the organosilane coupling agent improves the interfacial compatibility between inorganic tourmaline powder and organic carbon matrix and traditional Chinese medicine extract, making the tourmaline more uniformly dispersed and maintaining stable activity during heating. It realizes the multi-field coupling and linkage of thermal energy, piezoelectric microcurrent and far-infrared radiation, rather than the simple superposition of the functions of each component, which is conducive to realizing multi-level energy conversion of thermal energy to electrical energy to infrared energy.

[0015] 4. The herbal active ingredients in the active encapsulation are simultaneously loaded within the pores of the porous matrix and on the surface of the piezoelectric carrier. The porous channels of the graded carbonized matrix achieve long-term storage of active ingredients through physical adsorption, while the surface of the thermosensitive piezoelectric carrier enhances the binding strength of active ingredients through interfacial bonding. The two loading methods complement and synergistically bind the active ingredients, reducing the loss of volatile components and achieving long-term, stable release. This product has a simple preparation process and can be adapted to various dosage forms such as moxibustion patches, moxibustion cakes, moxibustion packs, and moxibustion plasters, meeting the long-term and convenient use needs of daily health care. The synergistic effect of each component significantly enhances the overall therapeutic effect. Attached Figure Description

[0016] Figure 1 This is a schematic diagram illustrating the overall process of a holographic moxibustion composition, its preparation method, and its application according to the present invention. Detailed Implementation The present invention will be further described below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of protection of the present invention.

[0017] This invention uses a thermosensitive piezoelectric carrier and a graded carbonized matrix as the core matrix, supplemented with a specific ratio of traditional Chinese medicine extracts and organosilane coupling agents, to construct a holographic moxibustion composition system with synergistic effects of heat, electricity, and infrared radiation. The components do not function independently; instead, they rely on material interface modification, graded pore structure, and thermo-piezoelectric response to form a positive cycle mechanism of multi-field coupling and linkage. After the product is applied to the skin, the far-infrared heat-gathering properties of the graded carbonized matrix create a localized mild micro-temperature environment of 40–55°C in the application area. This moderate temperature condition stably triggers the functional response of the thermosensitive piezoelectric carrier, thereby stimulating piezoelectric microcurrents, reducing the skin barrier to promote drug penetration, and enhancing local microcirculation metabolism after efficient drug penetration. The metabolic heat generation, in turn, maintains and strengthens the continuous piezoelectric activity. The components achieve functional complementarity through gradient ratios and interface modification, jointly realizing deep energy conduction and active transdermal drug delivery. The thermal piezoelectric carrier described in this invention is preferably black tourmaline, which is an iron-containing tourmaline variety. This material has a more stable spontaneous polarization effect and a higher infrared emissivity under warm conditions.

[0018] Each core component in this invention has the following function: The thermal piezoelectric carrier is surface-modified with an organosilane coupling agent, with tourmaline as the core substrate. The modification treatment can improve the interfacial compatibility between inorganic powders and carbon-based materials and traditional Chinese medicine extracts, and avoid powder agglomeration and uneven dispersion. In the local mild micro-temperature environment formed by the patch, the modified tourmaline can stably excite the piezoelectric response, continuously output a gentle and weak microcurrent, and simultaneously radiate high-quality far-infrared energy. The piezoelectric microcurrent can gently regulate the dense structure of the skin surface, reduce the penetration resistance of active ingredients, and provide auxiliary power for the transdermal absorption of traditional Chinese medicine.

[0019] The graded carbonized base material is a special moxa base material made through gradient segmented temperature-controlled carbonization. Unlike ordinary conventional moxa charcoal, it has a bimodal porous structure with both macropores and micropores. It can serve as a storage carrier for the active ingredients of traditional Chinese medicine, achieving a graded drug release effect that combines rapid release and long-term sustained release. It also has good heat storage, temperature concentration and far-infrared conduction capabilities. When applied, it can gather residual heat from the body surface to form a stable and mild micro-temperature environment, providing continuous triggering conditions for the thermosensitive piezoelectric carrier. At the same time, it exerts a deep infrared warming and soothing effect, and has both product shaping support and skin fit.

[0020] The active encapsulation material is based on a combination of herbal extracts. It is loaded into the composition through both physical adsorption and interfacial bonding. Some of the herbal active ingredients in the active encapsulation material are fixed in the porous structure of the graded carbonized matrix through physical adsorption, while the other part is attached to the surface of the modified thermosensitive piezoelectric carrier through interfacial bonding. The dual loading method can effectively reduce the loss of volatile herbal components, ensure stable and balanced release of efficacy, and achieve smooth transdermal absorption through the skin's permeable channels, soothing and regulating the body.

[0021] The raw materials for preparing the holographic moxibustion composition include, by weight, the following: 10–20 parts of a thermosensitive piezoelectric carrier, using ferroelectric tourmaline powder with a particle size of 5–15 μm, serve as the core energy generating unit of the system. Under the triggering of moxibustion heat, it can generate a piezoelectric microcurrent. This microcurrent can continuously regulate the local skin microenvironment, weaken the barrier effect of the stratum corneum, and synergistically improve the penetration efficiency of active ingredients, providing an active transdermal driving force for the active ingredients of traditional Chinese medicine. This ratio range can ensure sufficient charge density to change skin permeability without causing the molding structure to become loose or the flexibility to decrease due to excessive inorganic powder.

[0022] The graded carbonized base material, consisting of 60-70 parts, is prepared from aged Artemisia floss (3-5 years old) as the starting material through gradient temperature-controlled carbonization. This invention utilizes the natural tracheal structure of Artemisia floss fibers and the shrinkage effect during carbonization to construct a bimodal microporous network: the first stage, temperature-controlled at 220-250℃, removes volatile components from the fibers and initially forms macropores; the second stage, temperature-controlled at 300-330℃, induces fiber wall collapse through deep carbonization, forming dense micropores, ultimately resulting in a pore structure with a bimodal distribution. The differentiated pore sizes can be adapted to both rapid release and long-term stable storage of active ingredients, forming a graded drug release system combining fast and slow release. This component also possesses skeletal support and infrared modulation functions, forming a continuous, interconnected pore system at the specified dosage. It serves as a highly efficient carrier for active encapsulation materials and can also output highly penetrating far-infrared energy, achieving deep and gentle stimulation of holographic sites.

[0023] The weight ratio of the active encapsulant to the graded carbonized matrix is ​​controlled within the range of 1:5–1:15. This invention selects typical gradient ratios within this range for experiments, namely 1:5, 1:10, and 1:15. The active encapsulant is a compound extract of Artemisia argyi, Angelica sinensis, dried ginger, Clematis chinensis, and Lycopodium clavatum. As the material basis for the physiotherapy efficacy, it can be stably loaded onto the surface and pores of the porous matrix through physical adsorption and interfacial bonding. The dual loading modes of pore adsorption and carrier surface bonding work together to solve the defects of easy volatility, easy loss, and uneven release of single loading methods. Different concentration gradients can achieve differentiated release rates, avoiding the release of components due to excessive drug loading and excessive volatilization due to heating.

[0024] Organosilane coupling agents are used with thermosensitive piezoelectric carriers at a weight ratio of 1:50–1:200, using γ-aminopropyltriethoxysilane, γ-methacryloyloxypropyltrimethoxysilane, and γ-glycidoxypropyltrimethoxysilane, respectively. During the modification process, one end of the organosilane coupling agent binds to the hydroxyl groups on the surface of the thermosensitive piezoelectric carrier, while the other end improves the interfacial compatibility between the inorganic carrier and the organic Chinese medicine components, enhances the uniformity and structural stability of the system, and prevents the agglomeration of piezoelectric powders, which leads to a decrease in energy conversion efficiency.

[0025] This invention achieves synergistic function of each component through stepwise modification and blending: S1. Carrier modification: The thermosensitive piezoelectric carrier is mixed and stirred with the selected organosilane coupling agent to ensure that the organosilane coupling agent fully coats the surface of the thermosensitive piezoelectric carrier. S2. Graded carbonization: Artemisia floss is kept at a gradient temperature in a vacuum furnace to form a graded carbonized base material with a bimodal microporous structure. S3. Drug loading: The active encapsulated material is mixed with the graded carbonized matrix, and the active encapsulated material is fully adsorbed into the graded carbonized matrix under negative pressure. S4. Mixing and molding: The modified thermosensitive piezoelectric carrier is uniformly mixed with the drug-loaded graded carbonized base material and then molded to obtain a holographic moxibustion patch with a dense structure and stable performance. This allows the thermal effect, piezoelectric response and transdermal active ingredients to work synergistically to achieve deep therapeutic effects through the synergistic effect of heat, electricity and infrared multi-field.

[0026] The aged Artemisia floss used in this invention has been aged for 3–5 years; the tourmaline powder is made of ferro-tourmaline with an average particle size range of 5μm–15μm; the organosilane coupling agents are all industrial grade with a purity ≥98%. The testing instruments include: an ASAP2460 fully automatic surface area and porosity analyzer, a DPO4104 digital oscilloscope, and an RYJ-6B transdermal drug diffusion tester.

[0027] Example 1 The holographic moxibustion composition of this embodiment consists of the following raw materials in parts by weight: 10 parts of thermal piezoelectric carrier, 70 parts of graded carbonized base material, and 14 parts of active embedding material (the weight ratio of active embedding material to graded carbonized base material is 1:5).

[0028] Preparation process: Tourmaline powder was placed in a γ-aminopropyltriethoxysilane solution with a coupling agent to tourmaline weight ratio of 1:200. The mixture was stirred at 60°C for 3 hours. After the reaction was complete, it was filtered and dried at room temperature under ventilation to obtain the thermosensitive piezoelectric carrier. Aged moxa wool was heated at 220°C for 60 minutes, then heated to 300°C and held for 40 minutes to prepare a fractionated carbonized base material. The raw materials were mixed, filtered under reduced pressure, loaded, and subsequently pressed into shape to obtain the holographic moxibustion composition.

[0029] Example 2 The holographic moxibustion composition of this embodiment consists of the following raw materials in parts by weight: 15 parts of thermal piezoelectric carrier, 65 parts of graded carbonized base material, and 6.5 parts of active embedding material (the weight ratio of active embedding material to graded carbonized base material is 1:10).

[0030] Preparation process: Tourmaline powder was placed in a γ-methacryloyloxypropyltrimethoxysilane solution with a coupling agent to tourmaline weight ratio of 1:100. The mixture was stirred at 70°C for 2 hours. After the reaction was completed, the mixture was filtered and dried at room temperature under ventilation to obtain the thermosensitive piezoelectric carrier. Aged moxa wool was heated at 235°C for 45 minutes, then heated to 320°C and held for 30 minutes to prepare a fractionated carbonized base material. The raw materials were mixed, subjected to vacuum filtration and loading, and subsequently pressed into shape to obtain the holographic moxibustion composition.

[0031] Example 3 The holographic moxibustion composition of this embodiment consists of the following raw materials in parts by weight: 20 parts of thermal piezoelectric carrier, 60 parts of graded carbonized base material, and 4 parts of active embedding material (the weight ratio of active embedding material to graded carbonized base material is 1:15).

[0032] Preparation process: Tourmaline powder was placed in a γ-glycidyl etheroxypropyltrimethoxysilane solution with a coupling agent to tourmaline weight ratio of 1:50. The mixture was stirred at 80°C for 1 hour. After the reaction was completed, the mixture was filtered and dried at room temperature under ventilation to obtain the thermosensitive piezoelectric carrier. Aged moxa wool was heated at 250°C for 30 minutes, then heated to 330°C and held for 20 minutes to prepare a fractionated carbonized base material. The raw materials were mixed and subjected to high-pressure permeation loading to ensure that the active encapsulation was fully loaded into the pores of the base material and the surface of the carrier. Subsequent pressing and molding yielded the holographic moxibustion composition.

[0033] Example 4 The holographic moxibustion composition of this embodiment consists of the following raw materials in parts by weight: 12 parts of thermal piezoelectric carrier, 68 parts of graded carbonized base material, and 10 parts of active embedding material (the weight ratio of active embedding material to graded carbonized base material is 1:6.8).

[0034] Preparation process: Tourmaline powder was placed in a γ-aminopropyltriethoxysilane solution with a coupling agent to tourmaline weight ratio of 1:120. The mixture was stirred at 65°C for 2.5 h. After the reaction was completed, the mixture was filtered and dried at room temperature under ventilation to obtain the thermosensitive piezoelectric carrier. Aged moxa wool was heated at 230°C for 50 min, then heated to 310°C and held for 35 min to prepare a fractionated carbonized base material. The raw materials were mixed, subjected to vacuum filtration and loading, and subsequently pressed into shape to obtain the holographic moxibustion composition.

[0035] Example 5 The holographic moxibustion composition of this embodiment consists of the following raw materials in parts by weight: 18 parts of thermal piezoelectric carrier, 62 parts of graded carbonized base material, and 5 parts of active embedding material (the weight ratio of active embedding material to graded carbonized base material is 1:12.4).

[0036] Preparation process: Tourmaline powder was placed in a solution of γ-glycidyl etheroxypropyltrimethoxysilane, with a coupling agent to tourmaline weight ratio of 1:80. The mixture was stirred at 75°C for 1.5 h. After the reaction was completed, the mixture was filtered and dried at room temperature under ventilation to obtain the thermosensitive piezoelectric carrier. Aged moxa wool was heated at 240°C for 40 min, then heated to 325°C and held for 25 min to prepare a fractionated carbonized base material. The raw materials were mixed and subjected to high-pressure permeation loading, followed by pressing to obtain the holographic moxibustion composition.

[0037] Comparative Example 1 The composition ratio is the same as in Example 2, except that the thermal piezoelectric carrier is made of raw tourmaline powder that has not been modified by organosilane coupling agent.

[0038] Comparative Example 2 The composition ratio is the same as in Example 2, except that the base material is ordinary crushed Artemisia argyi powder that has not undergone gradient temperature-controlled carbonization treatment.

[0039] Comparative Example 3 The composition ratio is the same as in Example 2, except that the weight ratio of the active encapsulant to the graded carbonized base material is adjusted to 1:3, and the amount of active encapsulant added is excessive, exceeding the specified ratio range of this invention. All other raw materials, modification processes, carbonization processes, and preparation steps are consistent with those in Example 2.

[0040] Comparative Example 4 The component ratio is the same as in Example 2, except that the thermosensitive piezoelectric carrier (modified tourmaline) is removed and replaced with an equal amount of ordinary non-metallic mineral powder, which does not have thermo-piezoelectric response characteristics. The dosage of other components, loading method, and molding process are the same as in Example 2.

[0041] Comparative Example 5 Referring to Example 2, the difference is that: 8 parts of the thermal piezoelectric carrier, 72 parts of the graded carbonized base material, and 6.5 parts of the active encapsulant are used, and the component amounts deviate from the numerical range specified in this invention; the remaining modification, carbonization, and drug loading processes are consistent with Example 2.

[0042] Table 1: Summary Table of Distribution Ratios and Key Processes for Each Group Table 2: Comparison of Test Results for Key Performance Indicators The above performance tests were strictly performed in accordance with the standard experimental protocol to ensure that the test data were authentic, reliable, and reproducible: the piezoelectric voltage test used a 55℃ constant temperature stage to simulate the actual use environment of moxibustion therapy. The sample was placed on the constant temperature stage, and the voltage peak generated on the sample surface was continuously recorded for 10 minutes using a digital oscilloscope; the far-infrared emissivity test was conducted in the 8–14μm wavelength range to characterize the infrared radiation and energy conduction capabilities of the sample; the deep heat transmission test used 2mm thick fresh pigskin to simulate the biological barrier of human skin. A miniature thermistor was embedded 10mm below the barrier, and the temperature rise value monitored by the probe was continuously recorded after 20 minutes to directly reflect the deep heat penetration effect; the cumulative transdermal volume test used a Franz diffusion cell with detached pigskin as a barrier. Under constant temperature conditions of 55℃, the cumulative permeation of the active ingredient (calculated as angelica lactone) was determined by high performance liquid chromatography (HPLC) within 120 minutes to verify the active transdermal efficiency of the active ingredient.

[0043] Experiments show that the holographic moxibustion composition and its preparation method provided by this invention, through specific component ratios and process control, can achieve the following results: A holographic moxibustion composition with stable molding and uniform performance can be prepared by using a ratio of 10–20 parts of thermal piezoelectric carrier, 60–70 parts of graded carbonized base material, and 4–16 parts of active embedding material, and controlling the loading of active embedding material relative to the total mass of thermal piezoelectric carrier and graded carbonized base material to be 5%–20%, and the weight ratio of traditional Chinese medicine extract to graded carbonized base material to be 1:5–1:15.

[0044] Unlike conventional designs that simply mix and match existing technologies, this invention achieves unexpected synergistic effects among its components by defining a bimodal microporous structure, modifying the carrier surface, and using a dual-site loading method.

[0045] Within the range of raw material proportions, ratios, and process parameters defined in this invention, multiple sets of gradient examples were set up for verification. Examples 1 to 5 all used surface-modified ferroelectric powder as a thermosensitive piezoelectric carrier and semi-carbonized artemisia powder prepared by gradient carbonization as a graded carbonization base material.

[0046] Examples 1-3 represent the boundary and typical ratio experimental groups, exhibiting excellent overall performance. The peak voltage is 145–178 mV, the far-infrared emissivity (8-14 μm) is 0.90–0.93, the temperature rise at a depth of 10 mm is 4.0–4.7 °C, and the cumulative transdermal dose is 88.5–99.2 μg / cm².

[0047] Examples 4 and 5 represent the optimal intermediate ratios and process conditions within the specified range. All performance indicators are stable and fall within the numerical range of Examples 1 to 3. The peak voltages are 162mV and 171mV, respectively; the far-infrared emissivity is 0.91 and 0.92, respectively; the temperature rise at a depth of 10mm is 4.5℃ and 4.6℃, respectively; and the cumulative transdermal absorption is 95.7μg / cm² and 97.1μg / cm², respectively.

[0048] This demonstrates that by reasonably adjusting the component ratio and preparation conditions within the parameter range defined by this invention, the overall performance of the product exhibits small fluctuations and strong stability, the technical solution has good adaptability, and the consistency between industrial replication and mass production is excellent.

[0049] Comparative experiments between Comparative Example 1 and Example 2 show that the thermosensitive piezoelectric carrier without modification by organosilane coupling agent leads to a significant decrease in the performance of the composition: the peak voltage drops from 178mV in Example 2 to 40mV, the far-infrared emissivity drops from 0.93 to 0.81, the temperature rise at a depth of 10mm drops from 4.7℃ to 2.4℃, and the cumulative transdermal dose drops from 99.2μg / cm² to 36.2μg / cm².

[0050] Comparative experiments between Comparative Example 2 and Example 2 show that when ordinary crushed Artemisia argyi powder without gradient temperature-controlled carbonization treatment is used instead of graded carbonized base material, the performance of the composition is significantly weakened: the peak voltage drops from 178mV in Example 2 to 115mV, the far-infrared emissivity drops from 0.93 to 0.74, the temperature rise at a depth of 10mm drops from 4.7℃ to 1.7℃, and the cumulative transdermal absorption rate drops from 99.2μg / cm² to 43.8μg / cm².

[0051] Two sets of comparative examples directly verify that the modified piezoelectric carrier and the gradient bimodal carbonized matrix are essential core technical features of this invention. The lack of either feature will cause a significant decrease in overall performance, proving that this invention is not a simple combination of conventional materials, but has outstanding substantive features.

[0052] Comparative experiments between Comparative Example 3 and Example 2 showed that when the active encapsulant ratio was exceeded within the limits of this invention and excessive amounts of traditional Chinese medicine extract were added, the system became saturated and the pores became blocked, the synergistic effect was suppressed, and the overall performance deteriorated significantly: the peak voltage dropped from 178mV to 92mV, the far-infrared emissivity dropped from 0.93 to 0.83, the temperature rise at a depth of 10mm dropped from 4.7℃ to 2.8℃, and the cumulative transdermal dose dropped from 99.2μg / cm² to 52.6μg / cm².

[0053] Excessive active components cannot be effectively adsorbed and fixed, and are prone to precipitation and detachment. This hinders the conduction of piezoelectric effect and the release of far-infrared radiation, further demonstrating that the ratio range of traditional Chinese medicine extract and graded carbonized base material specified in this invention is strictly reasonable and necessary.

[0054] Comparative experiments between Comparative Example 4 and Example 2 show that after replacing the ordinary non-metallic mineral powder that does not have a thermosensitive piezoelectric response, the composition loses its core functional basis, and various indicators drop sharply: the peak voltage is only 18mV, the far-infrared emissivity is as low as 0.69, the temperature rise at a depth of 10mm is only 1.2℃, and the cumulative transdermal dose is only 21.4μg / cm².

[0055] It has been fully demonstrated that the modified tourmaline, as a thermosensitive piezoelectric carrier, is a key component for achieving multi-field synergy of electrothermal infrared radiation, assisting in deep temperature rise and transdermal absorption of active ingredients, and cannot be simply replaced by similar conventional inorganic powders.

[0056] Comparative experiments between Comparative Example 5 and Example 2 show that when the amounts of the thermosensitive piezoelectric carrier and the graded carbonized base material deviate from the numerical range specified in this invention, the system components become unbalanced, the proportion of microporous structure and the uniformity of piezoelectric material dispersion are destroyed, and the synergistic effect of multi-field coupling is greatly weakened: the peak voltage drops to 103mV, the far-infrared emissivity drops to 0.79, the temperature rises and falls to 2.1℃ at a depth of 10mm, and the cumulative transdermal dose drops to 39.5μg / cm².

[0057] This demonstrates that the strictly defined weight range of each raw material in this invention is not a conventional selectable range, but a necessary boundary condition to ensure the stability of the system structure and the synergistic matching of components. Any deviation from this range will directly impair the overall performance of the product.

[0058] Based on the comparison results of all embodiments and five sets of comparative examples, it can be determined that the present invention forms a complete and unique technical system by limiting specific raw material types, strictly controlling the weight range of components, controlling the active loading ratio, silane surface modification, gradient carbonization pore formation, and dual-site loading combined with synergistic cooperation.

[0059] The various technical features are mutually restrictive and synergistic, rather than simply superimposed or conventionally selected. In terms of piezoelectric power generation, far-infrared radiation, deep heat conduction, and sustained-release transdermal active ingredients, comprehensive optimization effects exceeding the expectations of existing technologies have been achieved, solving the industry pain points of traditional moxibustion therapy compositions such as single function, weak heat penetration, low utilization rate of effective ingredients, and poor material bonding stability.

[0060] The preparation process described in this invention (carrier modification—gradual carbonization—drug loading—compression molding) involves carrier modification by stirring at 60–80℃ for 1–3 hours and carbonization by gradient heating at 220–330℃. The process conditions are mild and controllable, and the target holographic moxibustion composition can be stably prepared, which is suitable for various dosage forms.

[0061] The above description of the disclosed embodiments enables those skilled in the art to make or use this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A holographic moxibustion composition, characterized in that, Including the following raw materials by weight: 10–20 parts of thermistor piezoelectric carrier; 60–70 parts of graded carbonized matrix; 4–16 parts of active encapsulant; The thermal piezoelectric carrier is a surface-modified tourmaline powder, and the surface modification method is to form an oleophilic coating layer on the surface of the tourmaline powder using an organosilane coupling agent. The graded carbonized base material is semi-carbonized artemisia powder with a porous structure, and its micropore size has a bimodal distribution. The active encapsulant is a traditional Chinese medicine extract, and the active encapsulant is loaded in the micropores of the graded carbonized matrix and on the surface of the thermosensitive piezoelectric carrier.

2. The holographic moxibustion composition according to claim 1, characterized in that, The average particle size of the thermosensitive piezoelectric carrier is 5μm–15μm; the bimodal micropore sizes of the graded carbonized matrix are 10–30nm and 80–120nm, respectively.

3. The holographic moxibustion composition according to claim 1, characterized in that, The organosilane coupling agent is selected from at least one of γ-aminopropyltriethoxysilane, γ-glycidoxypropyltrimethoxysilane, and γ-methacryloyloxypropyltrimethoxysilane.

4. The holographic moxibustion composition according to claim 1, characterized in that, The raw materials for the herbal extract are selected from one or more of the following: Artemisia argyi, Angelica sinensis, dried ginger, Clematis chinensis, and Lycopodium clavatum.

5. The holographic moxibustion composition according to claim 1, characterized in that, The loading of the active encapsulant relative to the total mass of the thermosensitive piezoelectric carrier and the graded carbonized matrix is ​​5%–20%.

6. A method for preparing the holographic moxibustion composition according to any one of claims 1-5, characterized in that, Includes the following steps: S1. Place tourmaline powder in an organosilane coupling agent solution, stir at 60–80°C for 1–3 hours, and dry to obtain a thermosensitive piezoelectric carrier. S2. Artemisia argyi floss is subjected to a gradient heating treatment of 200–330℃ in an anaerobic environment to obtain a graded carbonized base material with bimodal pore size. S3. After dissolving the Chinese herbal extract, mix it with the thermosensitive piezoelectric carrier and graded carbonized base material, and then filter it under reduced pressure or under high pressure permeation loading. S4. After mixing evenly, press and shape to obtain the holographic moxibustion composition.

7. The method for preparing the holographic moxibustion composition according to claim 6, characterized in that, In step S1, the weight ratio of the organosilane coupling agent to the tourmaline powder is 1:50–1:

200.

8. The method for preparing the holographic moxibustion composition according to claim 6, characterized in that, In step S3, the weight ratio of the traditional Chinese medicine extract to the graded carbonized base material is 1:5–1:

15.

9. The method for preparing the holographic moxibustion composition according to claim 6, characterized in that, In step S2, the gradient temperature rise is to first hold at 220–250℃ for 30–60 minutes, and then raise the temperature to 300–330℃ and hold for 20–40 minutes.

10. The use of the holographic moxibustion composition according to any one of claims 1-5 in the preparation of daily health care and physiotherapy products, or non-medical physiotherapy products with transdermal synergistic properties.

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