A skin-moisturizing and itching-relieving cream and a preparation method thereof

Abstract

This invention provides a moisturizing and antipruritic ointment, comprising the following raw materials in parts by weight: 5-15 parts Poria cocos, 5-15 parts Atractylodes lancea, 5-15 parts Phellodendron chinense, 5-15 parts Paeonia suffruticosa, 5-15 parts Dictamnus dasycarpus, 5-15 parts Portulaca oleracea, 5-15 parts Salvia miltiorrhiza, 5-15 parts Ligusticum chuanxiong, and 5-15 parts Glycyrrhiza uralensis. The preparation method of this moisturizing and antipruritic ointment is as follows: The volatile oil and water-soluble components of Ligusticum chuanxiong are extracted by distillation. Then, the remaining residue is decocted with other components, concentrated, and precipitated with alcohol to obtain a thick extract. Stearic acid, glyceryl monostearate, white petrolatum, liquid paraffin, and lanolin are then used to form an oil phase, and glycerin, sorbitol, sodium lauryl sulfate, and ethylparaben are used to form an aqueous phase. These are then emulsified and homogenized to obtain an ointment matrix. Finally, the thick extract and the volatile oil of Ligusticum chuanxiong are added to the ointment matrix, and after pH adjustment, defoaming, and cooling, the moisturizing and antipruritic ointment is obtained. This moisturizing and anti-itch cream has the effects of clearing heat and relieving itching, promoting blood circulation and moisturizing dryness, and is highly safe and has a good user experience.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparations and cosmetics technology, specifically relating to a skin-moisturizing and antipruritic ointment and its preparation method. Background Technology

[0002] Currently, most topical ointments for treating eczema and dermatitis in Western medicine are hormone-based, which can cause side effects with long-term use; while traditional Chinese medicine ointments have problems such as being greasy, having poor transdermal absorption, insufficient moisturizing, or focusing only on relieving itching while neglecting skin barrier repair. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a moisturizing and antipruritic ointment and its preparation method, which addresses the shortcomings of the prior art. The moisturizing and antipruritic ointment has the effects of clearing heat and relieving itching, promoting blood circulation and moisturizing dryness, and is highly safe and has a good user experience.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is: a moisturizing and antipruritic ointment, comprising the following raw materials in parts by weight: 5-15 parts Poria cocos, 5-15 parts Atractylodes lancea, 5-15 parts Phellodendron chinense, 5-15 parts Paeonia suffruticosa, 5-15 parts Dictamnus dasycarpus, 5-15 parts Portulaca oleracea, 5-15 parts Salvia miltiorrhiza, 5-15 parts Ligusticum chuanxiong, and 5-15 parts Glycyrrhiza uralensis.

[0005] Preferably, it is made from the following raw materials in parts by weight: 10 parts Poria cocos, 10 parts Atractylodes lancea, 10 parts Phellodendron chinense, 10 parts Paeonia suffruticosa, 10 parts Dictamnus dasycarpus, 10 parts Portulaca oleracea, 10 parts Salvia miltiorrhiza, 10 parts Ligusticum chuanxiong, and 10 parts Glycyrrhiza uralensis.

[0006] The method for preparing the above-mentioned moisturizing and antipruritic cream according to the present invention is as follows: S1. Clean and crush the Ligusticum chuanxiong, and then sieve it to obtain coarse powder of Ligusticum chuanxiong; S2. Poria cocos, Atractylodes lancea, Phellodendron chinense, Paeonia suffruticosa, Dictamnus dasycarpus, Portulaca oleracea, Salvia miltiorrhiza and Glycyrrhiza uralensis are cleaned, mixed and dried to obtain the dried Chinese medicine components. S3. Extraction of volatile oil and water-soluble components of Ligusticum chuanxiong: The crude powder of Ligusticum chuanxiong obtained in S1 was soaked in water for 1 hour and then distilled for 4 to 6 hours. The remaining residue and distillate were collected separately. The distillate was extracted 2 to 3 times with petroleum ether or diethyl ether. The upper organic phase and the lower aqueous phase were combined separately and recovered under reduced pressure to obtain the volatile oil extract of Ligusticum chuanxiong and the distilled liquid. S4. Mix the remaining dregs and the distilled liquid obtained in S3 with the dried Chinese herbal components obtained in S2, add water, decoct 2 to 3 times, combine the decoctions, sieve, and concentrate the filtrate under reduced pressure at a temperature of 60℃ to 65℃ and a pressure of -0.08MPa to -0.1MPa to obtain a paste-like substance. S5. Add 95% ethanol aqueous solution to the paste obtained in S4 for alcohol precipitation. Let it stand for 24h to 48h at 4℃~8℃, collect the precipitate, and take the supernatant to recover the alcohol under reduced pressure at ≤60℃ and -0.06MPa~-0.08MPa until there is no alcohol odor. The remaining liquid is further concentrated under reduced pressure at 60℃~65℃ and -0.08MPa~-0.1MPa to obtain the extract paste. S6. Preparation of oil phase: Stearic acid, glyceryl monostearate, white petrolatum, liquid paraffin and lanolin are mixed and heated to 75℃~80℃ to melt, and the oil phase is obtained. S7. Preparation of aqueous phase: Dissolve glycerol, sorbitol, sodium lauryl sulfate and ethylparaben in water, heat to 75℃~80℃ to obtain aqueous phase; S8. Emulsification and homogenization: The oil phase obtained in S6 is added to the aqueous phase obtained in S7 under stirring at a speed of 800 rpm to 1200 rpm. Stirring is continued for 15 min to 20 min at a temperature of 70℃ to 75℃. Then, the mixture is homogenized for 3 min to 5 min at a speed of 3000 rpm to obtain the cream matrix. S9. Mixed drug loading: When the temperature of the cream matrix obtained in S8 is 50℃~55℃, add the extract paste obtained in S5. After further cooling to a temperature of 40℃~45℃, disperse the volatile oil extract of Ligusticum chuanxiong obtained in S3 with Tween 80 and add it. After stirring evenly, the moisturizing and antipruritic cream to be packaged is obtained. S10. Adjust the pH of the moisturizing and antipruritic cream obtained in S9 to 5.5-6.5 with triethanolamine, degas under vacuum for 20-30 minutes, cool, and package to obtain the moisturizing and antipruritic cream.

[0007] Preferably, the mesh size of the sieve in S1 is 20-30 mesh; the drying conditions in S2 are: drying at a temperature of 55℃-60℃ for 4-6 hours; and the moisture content of the dried Chinese herbal medicine components in S2 is ≤10%.

[0008] Preferably, the mass ratio of the crude chuanxiong powder to water in S3 is 1:(8-10); the conditions for the reduced pressure recovery are: temperature ≤40℃ and pressure -0.06MPa to -0.08MPa.

[0009] Preferably, the relative density of the paste-like substance in S4 is 1.10 to 1.15.

[0010] Preferably, the conditions for alcohol precipitation in S5 are that the mass fraction of ethanol in the paste is 60% to 65%; and the relative density of the extract paste is 1.30 to 1.35.

[0011] Preferably, the oil phase in S6 is composed of the following raw materials in the indicated mass fractions: 8% stearic acid, 2% glyceryl monostearate, 38% liquid paraffin, 2% lanolin, and the balance being white petrolatum.

[0012] Preferably, the aqueous phase in S7 is composed of the following raw materials in the indicated mass fractions: 15% glycerol, 3% sorbitol, 0.8% sodium dodecyl sulfate, 0.03% ethylparaben, and the remainder being water.

[0013] The present invention uses Phellodendron bark, Dictamnus root bark, and Portulaca oleracea as the principal ingredients to clear away damp-heat toxins from the skin; Atractylodes lancea and Poria cocos as the assistant ingredients to strengthen the spleen and dry dampness, eliminating the source of dampness; Paeonia suffruticosa root bark, Salvia miltiorrhiza, and Ligusticum chuanxiong as the adjuvant ingredients to cool the blood and promote blood circulation, implementing the idea of ​​"treating wind by first treating blood, and wind will disappear when blood flows smoothly," and improving local nutrition of the skin lesions; Glycyrrhiza uralensis as the guiding ingredient to harmonize and enhance the effect; the entire formula not only relieves itching and treats the symptoms, but also focuses on regulating the internal environment of the skin and promoting repair, which is in line with the pathogenesis of chronic skin diseases involving "dampness, heat, blood stasis, and deficiency."

[0014] First Tier: Clearing Heat, Drying Dampness, and Promoting Diuresis (Treating the Root Cause, Resolving the Damp-Heat Environment): Phellodendron bark: Bitter, cold, and descending, it effectively clears damp-heat in the lower burner and is one of the principal herbs, a key medicine for treating damp-heat accumulation in the lower body and skin eczema. Atractylodes rhizome: Bitter, pungent, and warm, it dries dampness and strengthens the spleen. When combined with Phellodendron bark, it forms the famous formula "Er Miao San" (the core of this formula). One is cold, the other warm; one clears, the other dries, working together to clear damp-heat, leaving only heat after dampness is eliminated. Poria cocos: Sweet, bland, and neutral, it promotes urination and eliminates dampness, strengthens the spleen and calms the mind, helping dampness to be expelled through urination, providing an outlet for the pathogen, while simultaneously strengthening the spleen to prevent the source of dampness. Purslane: Sour and cold, it clears heat and detoxifies, cools the blood and stops bleeding, and promotes diuresis. It is an excellent medicine for treating heat-toxin sores and eczema, especially effective for skin redness, swelling, and oozing (yellowish discharge). This layer's function: Fundamentally clearing damp-heat from the body and improving the internal environment that breeds skin problems. Second Tier: Cooling and Activating Blood Circulation (Symptomatic Relief, Addressing Blood Heat and Stagnation): Moutan Cortex: Bitter, pungent, and slightly cold; clears heat and cools the blood, activates blood circulation and dispels blood stasis; clears latent heat in the blood and prevents blood heat from scorching and causing stasis. Salvia Miltiorrhiza: Bitter and slightly cold; activates blood circulation and removes blood stasis, cools the blood and reduces swelling, clears the heart and relieves irritability; a key medicine for activating blood circulation and removing blood stasis, and also nourishes the blood, ensuring that blood circulation is active without harming it. Ligusticum chuanxiong: Pungent and warm; a "qi-regulating medicine in the blood," activates blood circulation and qi, dispels wind and relieves pain; its properties ascend to the head and eyes, and extend to the limbs, promoting the circulation of qi and blood, and helping other medicines reach the affected area. Function of this layer: Traditional Chinese medicine believes that "prolonged illness enters the collaterals" and "damp-heat obstructs blood stasis." Stagnation of damp-heat leads to poor local blood circulation (blood stasis), while blood heat aggravates redness, swelling, itching, and pain. This layer of medicines can clear blood heat, activate blood vessels, improve local microcirculation, and promote skin lesion repair. Third Tier: Relieving Wind and Itching (Symptomatic Treatment, Addressing the Main Symptom): Dictamnus dasycarpus root bark: Bitter and cold in nature, it clears heat and dries dampness, dispels wind and detoxifies, and relieves itching. It is a specialized medicine for treating skin diseases caused by wind-heat-dampness toxins, and is remarkably effective for eczema, urticaria, and other conditions with severe itching. This tier's function: Directly targets the core symptom of skin diseases—itching—with rapid onset of action. Fourth Tier: Harmonizing Other Herbs: Licorice root: Sweet and neutral in nature, it tonifies qi and strengthens the middle jiao, clears heat and detoxifies, and harmonizes other herbs. In this formula, its dosage is not light; it can both mitigate the drying and pungent properties of Phellodendron bark and Atractylodes lancea, and enhance the detoxifying effect while protecting the spleen and stomach.

[0015] Compared with the prior art, the present invention has the following advantages: 1. This invention employs a stepwise extraction process combining steam distillation with water decoction and alcohol precipitation purification, which can simultaneously retain the volatile oil and water-soluble active ingredients in Ligusticum chuanxiong, thereby improving the utilization rate of raw materials and the retention rate of active ingredients.

[0016] 2. The extraction process of the present invention is mild, with low-pressure concentration and recovery temperatures, which can reduce the thermal decomposition of active ingredients and improve the stability of the extract.

[0017] 3. By optimizing the composition and ratio of the oil phase and water phase, the present invention produces a cream with a fine and uniform texture, good spreadability, and moderate adhesion, which is conducive to skin absorption and provides high comfort during use.

[0018] 4. The process of this invention is stable and controllable with good repeatability, making it suitable for industrial production. The resulting topical preparation has high safety and good application prospects.

[0019] The present invention will be further described in detail below with reference to the embodiments. Detailed Implementation

[0020] Example 1

[0021] The moisturizing and antipruritic ointment of this embodiment is made from the following ingredients in parts by weight: 10 parts Poria cocos, 10 parts Atractylodes lancea, 10 parts Phellodendron chinense, 10 parts Paeonia suffruticosa, 10 parts Dictamnus dasycarpus, 10 parts Portulaca oleracea, 10 parts Salvia miltiorrhiza, 10 parts Ligusticum chuanxiong, and 10 parts Glycyrrhiza uralensis.

[0022] The method for preparing the moisturizing and antipruritic cream in this embodiment is as follows: S1. Clean and crush the Ligusticum chuanxiong, and pass it through a 25-mesh sieve to obtain coarse powder of Ligusticum chuanxiong; S2. The cleaned Poria cocos, Atractylodes lancea, Phellodendron chinense, Paeonia suffruticosa, Dictamnus dasycarpus, Portulaca oleracea, Salvia miltiorrhiza and Glycyrrhiza uralensis are mixed and dried at 57℃ for 5 hours to obtain the dried Chinese medicine components with a moisture content of 5%. Drying removes moisture, which facilitates preservation and pulverization, and prevents mold growth; S3. Extraction of volatile oil and water-soluble components of Ligusticum chuanxiong: The crude powder of Ligusticum chuanxiong obtained in S1 was soaked in water for 1 hour and then steam distilled for 5 hours. The distillation rate was controlled at 1.2 times the weight of the medicinal material per hour. The remaining residue and distillate were collected separately. The distillate was extracted three times with petroleum ether. The upper organic phase and the lower aqueous phase were combined separately. The solvent was recovered under reduced pressure at a temperature of 30℃ and a pressure of -0.07MPa to obtain the volatile oil extract of Ligusticum chuanxiong and the distilled medicinal liquid. The mass ratio of the crude chuanxiong powder to water is 1:10; Steam distillation can efficiently extract heat-sensitive volatile oil components; extraction can enrich and purify volatile oils from the distillate. S4. Mix the remaining dregs and the distilled liquid obtained in S3 with the dried Chinese herbal components obtained in S2, add water, and decoct three times (first decoction: add 9 times the amount of water, boil and maintain a gentle boil for 1.5 hours; second decoction: add 7 times the amount of water, boil and maintain a gentle boil for 1 hour; third decoction: add 6 times the amount of water, boil and maintain a gentle boil for 1 hour). Combine the decoctions, filter with a 200-mesh sieve, and concentrate the filtrate under reduced pressure at a temperature of 62℃ and a pressure of -0.09MPa to obtain a paste-like substance with a relative density of 1.15 (measured at 60℃). Decoction is used to extract water-soluble active ingredients (alkaloids, glycosides, polysaccharides, etc.); low-temperature rapid concentration is used to prevent the destruction of heat-sensitive components. S5. Add a 95% ethanol aqueous solution to the paste obtained in S4 and precipitate the ethanol until the ethanol content in the paste is 63%. Let it stand for 36 hours at 4°C, collect the precipitate, and take the supernatant to recover the alcohol odor under reduced pressure at 40°C and -0.07 MPa. The remaining solution is further concentrated under reduced pressure at 62°C and -0.09 MPa to obtain a thick extract paste with a relative density of 1.32 (measured at 60°C). Alcohol precipitation removes large molecular impurities such as starch and protein, improving the stability and purity of the paste; S6. Preparation of oil phase: Stearic acid, glyceryl monostearate, white petrolatum, liquid paraffin and lanolin are mixed and heated to 78°C to melt, and the oil phase is obtained. The oil phase is composed of the following raw materials by mass fraction: 8% stearic acid, 2% glyceryl monostearate, 38% liquid paraffin, 2% lanolin, and the balance being white petrolatum; S7. Preparation of aqueous phase: Dissolve glycerol, sorbitol, sodium lauryl sulfate and ethylparaben in water, heat to 78°C to obtain the aqueous phase; The aqueous phase is composed of the following raw materials in the indicated mass fractions: 15% glycerol, 3% sorbitol, 0.8% sodium lauryl sulfate, 0.03% ethylparaben, and the remainder being water; S8. Emulsification and homogenization: The oil phase obtained in S6 was added to the aqueous phase obtained in S7 under high-speed stirring at 1000 rpm. After stirring for 18 min at 73℃, the mixture was homogenized for 4 min at 4000 rpm to obtain the cream matrix. Emulsification temperature ensures complete melting of all phases and consistent fluidity, achieving stable emulsification; homogenization reduces the droplet size of the oil phase, resulting in a fine and stable cream matrix; S9. Mixed drug loading: When the temperature of the cream matrix obtained in S8 is 55℃, add the extract paste obtained in S5 under stirring. Further cool to 45℃ (below the boiling point of the volatile oil), disperse the chuanxiong volatile oil extract obtained in S3 with Tween 80 and add it. After stirring evenly, the moisturizing and antipruritic cream to be packaged is obtained. S10. The pH of the moisturizing and antipruritic cream obtained in S10 is adjusted to 6.0 with triethanolamine to match the physiological pH of the skin and reduce irritation. Vacuum degassing is performed for 25 minutes, and the product is cooled to room temperature and filled into sterilized aluminum tubes to obtain the moisturizing and antipruritic cream.

[0023] This embodiment also provides the application of the moisturizing and antipruritic cream prepared above.

[0024] Indications: Clears heat and promotes diuresis, cools blood and promotes blood circulation, dispels wind and relieves itching.

[0025] Dosage and administration: Apply externally, 0.1g each time, three times a day.

[0026] Precautions for use: This medication is contraindicated for pregnant women and those with broken skin.

[0027] (1) Patient Yang, male, 64 years old, from Guiyang City, came to the clinic at 10:00 on April 30, 2024. Chief complaint: generalized erythema and papules with itching for more than 1 year, which has worsened in the past week. Present illness: The patient said that more than 1 year ago, he developed generalized scattered erythema and papules without any obvious cause. He was itchy and uncomfortable, but it did not affect his daily life or sleep at night. At that time, he had no fever, chills, palpitations, chest tightness or other discomfort. He denied any special contact history or medication history. He was treated at the First People's Hospital of Guiyang City. After treatment, his symptoms were slightly relieved. One week ago, he felt that the itching in the rash area was more severe than before without any obvious cause. It was more severe on the trunk and lower limbs. The itching was obvious at night, which seriously affected his daily life and sleep at night. He is now seeking systemic Chinese and Western medicine integrated treatment and has visited the Emergency Department of the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine. He was also treated in our department for "Siwanfeng". Outpatient presentation: The patient experienced severe, generalized itching, frequently scratching, which significantly impacted daily life and sleep. There was no fever, chills, cough, sputum, difficulty breathing, a feeling of obstruction in the throat, palpitations, or chest tightness. The patient's mental state was good, appetite was good, sleep was poor, bowel movements were normal, tongue was red with a yellow, greasy coating, and pulse was slippery and rapid. An initial prescription of 7 boxes of medication was given. After taking the medication, the above symptoms improved, and the itching slightly subsided, although a few scattered erythema and papules remained. After continuing to use 7 boxes, the generalized itching symptoms significantly decreased, and the erythema and papules largely disappeared. Continued use of 7 boxes resulted in no recurrence to date.

[0028] (2) Patient Cai, female, 67 years old, from Guiyang City, came to the clinic at 12:00 on May 6, 2024. Chief complaint: generalized erythema and papules with itching for more than 10 years, which has worsened in the past half month. Present illness: More than 10 years ago, the patient developed erythema and papules without obvious cause, with itching and discomfort, which did not affect her daily life and sleep. At that time, she had no chills or fever, no cough or sputum, no difficulty breathing, no feeling of obstruction in the throat, no palpitations or chest tightness, and denied any history of mosquito bites or contact with irritants. More than 3 years ago, the patient developed erythema and papules all over her body without obvious cause, with significant itching. Therefore, she went to a local clinic and was treated with "intramuscular injection and topical application of drugs". Her condition improved slightly. Since then, the above symptoms have recurred. Half a month ago, the patient felt that the itching had worsened significantly without obvious cause. She scratched frequently. When the itching occurred, it seriously affected her daily life and sleep. Now, in order to seek systemic integrated Chinese and Western medicine treatment, she came to our hospital's emergency department and was treated in our department for "four-bend wind". Outpatient presentation: The patient experienced unbearable itching all over the body, with frequent scratching, especially at night, presenting as paroxysmal needle-like pain. The pain affected daily life and sleep during attacks, while the itching severely impacted daily life and sleep. There were no chills, fever, cough, sputum, nausea, vomiting, or other discomforts. The patient's mental state was fair, appetite was good, sleep was poor, urination was normal, and bowel movements were sometimes loose. The tongue was red with a yellow and greasy coating, and the pulse was slippery. The initial prescription was 7 boxes of medicine. After taking the medicine, the above symptoms improved, but a small amount of erythema and papules remained, and the skin itching was slightly improved. The patient continued to use 7 boxes, after which the erythema and papules largely subsided, and the itching was significantly relieved. The patient continued to use 7 boxes, and there has been no recurrence to date.

[0029] (3) Patient Zeng, female, 60 years old, from Guiyang City, came to the clinic at 11:00 on May 7, 2024, with the chief complaint of pain and rash on the left side of the waist, hip, and lower limb for more than 3 weeks. Present illness: More than 3 weeks ago, the patient developed pain in the left side of the waist, hip, and leg without any obvious cause. The pain was paroxysmal and needle-like, with local erythema and papules. There was no chills or fever, no palpitations or chest tightness, no nausea or vomiting, no abdominal distension or diarrhea. The pain affected her daily life and sleep. She denied any history of mosquito bites or special contact with insects. She was hospitalized at "300 Hospital" (the specific treatment process is unknown). The rash gradually subsided, but the pain did not improve significantly. She then came to our outpatient department and was diagnosed with herpes zoster. She was treated with "intralesional injection, oral mecobalamin, vitamin B1, and pregabalin capsules", but the pain relief was not significant. It seriously affected her sleep. Now, seeking systemic integrated traditional Chinese and Western medicine treatment, she came to our emergency department and was treated for "shingles" in our department. Outpatient presentation: The patient experienced significant, intermittent, needle-like pain in the left lumbar region, hip, and lower limb. The pain significantly impacted daily life and sleep, accompanied by mild itching. There was no chills, fever, dizziness, headache, abdominal distension, diarrhea, nausea, or vomiting. The patient's mental state was fair, appetite was good, sleep was poor, bowel movements were normal, tongue was red with a slightly greasy yellow coating, and pulse was wiry and slippery. An initial prescription of 7 boxes of medication was given. After taking the medication, the above symptoms improved, although a small amount of erythema and papules remained, and the itching slightly improved. Another 7 boxes were used, after which the erythema and papules largely subsided, and the itching was significantly relieved. Another 7 boxes were used, and no recurrence has been observed to date.

[0030] (4) Patient Ma, male, 59 years old, from Guiyang City, came to the clinic at 11:00 on May 7, 2024, with the chief complaint of erythema and papules on the trunk and limbs accompanied by itching for more than 3 months. Present illness: More than 3 months ago, the patient developed scattered erythema and papules all over his body without any obvious cause, with itching and discomfort, which did not affect his daily life or sleep at night. At that time, he had no chills or fever, no cough or sputum, no difficulty breathing, no feeling of obstruction in the throat, no nausea or vomiting, and denied any history of mosquito bites or contact with irritants. He visited the "Guiyang Nanming District People's Hospital" and was diagnosed with "eczema". He was given "rupatadine tablets and compound glycyrrhizin tablets orally" and the symptoms were slightly relieved. After that, the above symptoms recurred. The patient took "cetirizine dispersible tablets and loratadine tablets orally and dexamethasone acetate ointment externally" and the symptoms were slightly relieved. After stopping the medication, the symptoms worsened. Now, in order to seek systemic integrated traditional Chinese and Western medicine treatment, he came to our hospital's emergency department and was treated in our department for "eczema". Outpatient presentation: The patient experienced intense itching on the rash areas of the trunk and limbs, leading to frequent scratching, especially at night. The itching severely impacted daily life and sleep. There were no chills, fever, cough with phlegm, dizziness, headache, abdominal distension, diarrhea, nausea, or vomiting. The patient's mental state was fair, appetite was good, sleep was poor, bowel movements were normal, tongue was red with a yellow, greasy coating, and pulse was wiry and slippery. An initial prescription of 7 boxes of medication was given. After taking the medication, the above symptoms improved, although a small amount of erythema and papules remained, and the itching slightly improved. Another 7 boxes were used, after which the erythema and papules largely subsided, and the itching was significantly relieved. Another 7 boxes were used, and no recurrence has been observed to date.

[0031] Example 2

[0032] The moisturizing and antipruritic ointment of this embodiment is made from the following ingredients in parts by weight: 5 parts Poria cocos, 5 parts Atractylodes lancea, 5 parts Phellodendron chinense, 5 parts Paeonia suffruticosa, 5 parts Dictamnus dasycarpus, 5 parts Portulaca oleracea, 5 parts Salvia miltiorrhiza, 5 parts Ligusticum chuanxiong, and 5 parts Glycyrrhiza uralensis.

[0033] The method for preparing the moisturizing and antipruritic cream in this embodiment is as follows: S1. Clean and crush the Ligusticum chuanxiong, and pass it through a 20-mesh sieve to obtain coarse powder of Ligusticum chuanxiong; S2. The cleaned Poria cocos, Atractylodes lancea, Phellodendron chinense, Paeonia suffruticosa, Dictamnus dasycarpus, Portulaca oleracea, Salvia miltiorrhiza and Glycyrrhiza uralensis are mixed and dried at 55℃ for 6 hours to obtain the dried Chinese medicine components with a moisture content of 10%. S3. Extraction of volatile oil and water-soluble components of Ligusticum chuanxiong: The crude powder of Ligusticum chuanxiong obtained in S1 was soaked in water for 1 hour and then steam distilled for 4 hours. The distillation rate was controlled to be 1 times the weight of the medicinal material per hour. The remaining residue and distillate were collected separately. The distillate was extracted twice with diethyl ether. The upper organic phase and the lower aqueous phase were combined separately. The solvent was recovered under reduced pressure at a temperature of 40℃ and a pressure of -0.06MPa to obtain the volatile oil extract of Ligusticum chuanxiong and the distilled medicinal liquid. The mass ratio of the crude chuanxiong powder to water is 1:8; S4. Mix the remaining dregs and the distilled liquid obtained in S3 with the dried Chinese herbal components obtained in S2, add water, and decoct twice (first decoction: add 8 times the amount of water, boil and maintain a gentle boil for 1.5 hours; second decoction: add 6 times the amount of water, boil and maintain a gentle boil for 1 hour). Combine the decoctions, filter with a 200-mesh sieve, and concentrate the filtrate under reduced pressure at 60℃ and -0.08MPa to obtain a paste-like substance with a relative density of 1.10 (measured at 60℃). S5. Add 95% ethanol aqueous solution to the paste obtained in S4 and precipitate the ethanol until the mass fraction of ethanol in the paste is 60%. Let it stand for 24 hours at 6℃, collect the precipitate, and take the supernatant to recover the alcohol odor under reduced pressure at 60℃ and -0.06MPa. The remaining solution is further concentrated under reduced pressure at 60℃ and -0.08MPa to obtain extract paste A with a relative density of 1.30 (measured at 60℃). S6. Add 7 times the amount of 75% ethanol aqueous solution to the collected precipitate and reflux twice for 1.5 hours each time. Combine the ethanol extracts and recover the ethanol under reduced pressure until there is no alcohol odor to obtain extract B. This step can enhance the extraction of fat-soluble active ingredients (such as tanshinone and paeonol) from medicinal materials such as peony bark and salvia miltiorrhiza. S7. Preparation of oil phase: Stearic acid, glyceryl monostearate, white petrolatum, liquid paraffin and lanolin are mixed and heated to 75°C to melt, and the oil phase is obtained. S8. Preparation of aqueous phase: Dissolve glycerol, sorbitol, sodium lauryl sulfate and ethylparaben in water, heat to 75°C to obtain the aqueous phase; S9. Emulsification and homogenization: The oil phase obtained in S7 is added to the aqueous phase obtained in S8 under high-speed stirring at 800 rpm. After stirring for 15 min at 70℃, the mixture is homogenized for 3 min at 3000 rpm to obtain the cream matrix. S10, Mixed drug loading: When the temperature of the cream matrix obtained in S9 is 50℃, add the extract paste A obtained in S5 and the extract paste B obtained in S6 under stirring. Further cool to 40℃ (below the boiling point of volatile oil), disperse the chuanxiong volatile oil extract obtained in S3 with Tween 80 and add it. After stirring evenly, the moisturizing and antipruritic cream to be packaged is obtained. S11. Adjust the pH of the moisturizing and antipruritic ointment obtained in S10 to 5.5 with triethanolamine to match the physiological pH of the skin and reduce irritation. Vacuum degas for 20 minutes, cool to room temperature, and fill into sterilized plastic ointment boxes to obtain the moisturizing and antipruritic ointment.

[0034] Example 3

[0035] The moisturizing and antipruritic ointment of this embodiment is made from the following ingredients in parts by weight: 15 parts Poria cocos, 15 parts Atractylodes lancea, 15 parts Phellodendron chinense, 15 parts Paeonia suffruticosa, 15 parts Dictamnus dasycarpus, 15 parts Portulaca oleracea, 15 parts Salvia miltiorrhiza, 15 parts Ligusticum chuanxiong, and 15 parts Glycyrrhiza uralensis.

[0036] The method for preparing the moisturizing and antipruritic cream in this embodiment is as follows: S1. Clean and crush the Ligusticum chuanxiong, and pass it through a 30-mesh sieve to obtain coarse powder of Ligusticum chuanxiong; S2. The cleaned Poria cocos, Atractylodes lancea, Phellodendron chinense, Paeonia suffruticosa, Dictamnus dasycarpus, Portulaca oleracea, Salvia miltiorrhiza and Glycyrrhiza uralensis are mixed and dried at 60℃ for 4 hours to obtain the dried Chinese medicine components with a moisture content of 3%. S3. Extraction of volatile oil and water-soluble components of Ligusticum chuanxiong: The crude powder of Ligusticum chuanxiong obtained in S1 was soaked in water for 1 hour and then steam distilled for 6 hours. The distillation rate was controlled at 1.5 times the weight of the medicinal material per hour. The remaining residue and distillate were collected separately. The distillate was extracted twice with petroleum ether. The upper organic phase and the lower aqueous phase were combined separately. The solvent was recovered under reduced pressure at a temperature of 20℃ and a pressure of 0.08MPa to obtain the volatile oil extract of Ligusticum chuanxiong and the distilled medicinal liquid. The mass ratio of the crude chuanxiong powder to water is 1:9; S4. Mix the remaining dregs and the distilled liquid obtained in S3 with the dried Chinese herbal components obtained in S2, add water, and decoct twice (first decoction: add 10 times the amount of water, boil and maintain a gentle boil for 2 hours; second decoction: add 8 times the amount of water, 1.5 hours). Combine the decoctions, filter with a 200-mesh sieve, and concentrate the filtrate under reduced pressure at a temperature of 65℃ and a pressure of -0.1MPa to obtain a paste-like substance with a relative density of 1.12 (measured at 60℃). S5. Add a 95% ethanol aqueous solution to the paste obtained in S4 and precipitate the ethanol until the ethanol content in the paste is 65%. Let it stand at 8°C for 48 hours, collect the precipitate, and take the supernatant to reduce the pressure at 30°C and -0.08 MPa until no alcohol odor is detected. Continue to concentrate the remaining solution under reduced pressure at 65°C and -0.1 MPa to obtain a thick extract paste with a relative density of 1.35 (measured at 60°C). Alcohol precipitation removes large molecular impurities such as starch and protein, improving the stability and purity of the paste; S6. Preparation of oil phase: Stearic acid, glyceryl monostearate, white petrolatum, liquid paraffin and lanolin are mixed and heated to 80°C to melt, and the oil phase is obtained. S7. Preparation of aqueous phase: Dissolve glycerol, sorbitol, sodium lauryl sulfate and ethylparaben in water, heat to 80°C to obtain the aqueous phase; S8. Emulsification and homogenization: The oil phase obtained in S6 was added to the aqueous phase obtained in S7 under high-speed stirring at 1200 rpm. After stirring for 20 min at 75 ℃, the mixture was homogenized for 5 min at 5000 rpm to obtain the cream matrix. S9. Mixed drug loading: When the temperature of the cream matrix obtained in S8 is 53℃, add the extract paste obtained in S5 under stirring. Further cool to 43℃ (below the boiling point of volatile oil), disperse the volatile oil extract of Ligusticum chuanxiong obtained in S3 with Tween 80 and add it. After stirring evenly, the moisturizing and antipruritic cream to be packaged is obtained. S10. The pH value of the moisturizing and antipruritic cream obtained in S10 is adjusted to 6.5 with triethanolamine to match the physiological pH value of the skin and reduce irritation. Vacuum degassing is performed for 30 minutes, and the product is cooled to room temperature and filled into sterilized aluminum tubes to obtain the moisturizing and antipruritic cream.

[0037] In summary, the pathogenesis of skin problems is "internal damp-heat, combined with blood heat and blood stasis, manifesting on the skin." Damp-heat is the soil, while blood heat and blood stasis are the pathological products, jointly leading to skin problems. The moisturizing and antipruritic ointment of this invention is suitable for eczema and dermatitis, especially in the subacute or chronic stages, characterized by dark red, rough, thickened, scaly skin, scratch marks, and blood crusts, intense itching, possibly accompanied by a small amount of exudation, a dark tongue or petechiae, and a yellow, greasy tongue coating; nodular prurigo and chronic urticaria, belonging to the damp-heat stagnation type, with stubborn, dark-colored lesions; acne (cystic nodular type), characterized by dark red color, hard texture, and recurring recurrence; and erysipelas of the lower extremities and postherpetic neuralgia (damp-heat stagnation type). Although the formula of this moisturizing and antipruritic ointment contains many bitter and cold herbs, and is harmonized with licorice, those with spleen and stomach deficiency (prone to diarrhea and coldness) should still exercise caution or adjust the formula accordingly.

[0038] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention in any way. Any simple modifications, alterations, and equivalent changes made to the above embodiments based on the inventive essence shall still fall within the protection scope of the present invention.

Claims

1. A moisturizing and antipruritic cream, characterized in that, It is made from the following ingredients in parts by weight: Poria cocos 5-15 parts, Atractylodes lancea 5-15 parts, Phellodendron chinense 5-15 parts, Paeonia suffruticosa 5-15 parts, Dictamnus dasycarpus 5-15 parts, Portulaca oleracea 5-15 parts, Salvia miltiorrhiza 5-15 parts, Ligusticum chuanxiong 5-15 parts, Glycyrrhiza uralensis 5-15 parts.

2. The moisturizing and antipruritic cream according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 10 parts Poria cocos, 10 parts Atractylodes lancea, 10 parts Phellodendron chinense, 10 parts Paeonia suffruticosa, 10 parts Dictamnus dasycarpus, 10 parts Portulaca oleracea, 10 parts Salvia miltiorrhiza, 10 parts Ligusticum chuanxiong, and 10 parts Glycyrrhiza uralensis.

3. A method for preparing the moisturizing and antipruritic ointment as described in claim 1 or 2, characterized in that, The method is as follows: S1. Clean and crush the Ligusticum chuanxiong, and then sieve it to obtain coarse powder of Ligusticum chuanxiong; S2. Poria cocos, Atractylodes lancea, Phellodendron chinense, Paeonia suffruticosa, Dictamnus dasycarpus, Portulaca oleracea, Salvia miltiorrhiza and Glycyrrhiza uralensis are cleaned, mixed and dried to obtain the dried Chinese medicine components. S3. Extraction of volatile oil and water-soluble components of Ligusticum chuanxiong: The crude powder of Ligusticum chuanxiong obtained in S1 was soaked in water for 1 hour and then distilled for 4 to 6 hours. The remaining residue and distillate were collected separately. The distillate was extracted 2 to 3 times with petroleum ether or diethyl ether. The upper organic phase and the lower aqueous phase were combined separately and recovered under reduced pressure to obtain the volatile oil extract of Ligusticum chuanxiong and the distilled liquid. S4. Mix the remaining dregs and the distilled liquid obtained in S3 with the dried Chinese herbal components obtained in S2, add water, decoct 2 to 3 times, combine the decoctions, sieve, and concentrate the filtrate under reduced pressure at a temperature of 60℃ to 65℃ and a pressure of -0.08MPa to -0.1MPa to obtain a paste-like substance. S5. Add 95% ethanol aqueous solution to the paste obtained in S4 for alcohol precipitation. Let it stand for 24h to 48h at 4℃~8℃, collect the precipitate, and take the supernatant to recover the alcohol under reduced pressure at ≤60℃ and -0.06MPa~-0.08MPa until there is no alcohol odor. The remaining liquid is further concentrated under reduced pressure at 60℃~65℃ and -0.08MPa~-0.1MPa to obtain the extract paste. S6. Preparation of oil phase: Stearic acid, glyceryl monostearate, white petrolatum, liquid paraffin and lanolin are mixed and heated to 75℃~80℃ to melt, and the oil phase is obtained. S7. Preparation of aqueous phase: Dissolve glycerol, sorbitol, sodium lauryl sulfate and ethylparaben in water, heat to 75℃~80℃ to obtain aqueous phase; S8. Emulsification and homogenization: The oil phase obtained in S6 is added to the aqueous phase obtained in S7 under stirring at a speed of 800 rpm to 1200 rpm. Stirring is continued for 15 min to 20 min at a temperature of 70℃ to 75℃. Then, the mixture is homogenized for 3 min to 5 min at a speed of 3000 rpm to obtain the cream matrix. S9. Mixed drug loading: When the temperature of the cream matrix obtained in S8 is 50℃~55℃, add the extract paste obtained in S5. After further cooling to a temperature of 40℃~45℃, disperse the volatile oil extract of Ligusticum chuanxiong obtained in S3 with Tween 80 and add it. After stirring evenly, the moisturizing and antipruritic cream to be packaged is obtained. S10. Adjust the pH of the moisturizing and antipruritic cream obtained in S9 to 5.5-6.5 with triethanolamine, degas under vacuum for 20-30 minutes, cool, and package to obtain the moisturizing and antipruritic cream.

4. The method according to claim 3, characterized in that, The sieve size in S1 is 20-30 mesh; the drying conditions in S2 are: drying at a temperature of 55℃-60℃ for 4-6 hours; the moisture content of the dried Chinese herbal medicine components in S2 is ≤10%.

5. The method according to claim 3, characterized in that, The mass ratio of crude chuanxiong powder to water in S3 is 1:(8-10); the conditions for vacuum recovery are: temperature ≤40℃ and pressure -0.06MPa to -0.08MPa.

6. The method according to claim 3, characterized in that, The relative density of the paste-like substance described in S4 is 1.10 to 1.

15.

7. The method according to claim 3, characterized in that, The conditions for alcohol precipitation described in S5 are that the mass fraction of ethanol in the paste is 60% to 65%; and the relative density of the extract paste is 1.30 to 1.

35.

8. The method according to claim 3, characterized in that, The oil phase described in S6 is composed of the following raw materials by mass fraction: 8% stearic acid, 2% glyceryl monostearate, 38% liquid paraffin, 2% lanolin, and the balance being white petrolatum.

9. The method according to claim 3, characterized in that, The aqueous phase described in S7 consists of the following raw materials in the indicated mass fractions: 15% glycerol, 3% sorbitol, 0.8% sodium dodecyl sulfate, 0.03% ethylparaben, and the remainder being water.