Pharmaceutical composition for delaying aging and capable of antioxidation

Abstract

A pharmaceutical composition for delaying aging and providing antioxidant effects belongs to the fields of biomedicine and health food technology. The composition includes vitamin A, β-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; traditional Chinese medicine ingredients such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum; royal jelly; conditionally essential nutrients such as nucleic acids; and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, and chlorophyll. It is primarily suitable for middle-aged and elderly individuals. This composition eliminates multiple factors contributing to aging from multiple systems, multiple links, and multiple targets, significantly delaying aging and providing antioxidant and other health benefits. While delaying aging, it also improves the quality of life for middle-aged and elderly individuals. This composition has no contraindications and no toxic side effects.

Description

[0001] Technical Field: This invention relates to the fields of biomedicine and health food technology; in particular, pharmaceutical compositions for delaying aging and having antioxidant properties.

[0002] Background Technology: Aging is a physiological phenomenon in which the functions of various organs in the human body gradually decline. It is a slow and gradual process, an inevitable natural law. There are many theories about the causes of human aging, but they all boil down to the aging of cells and tissues. As the basic building blocks of the human body, cells cannot meet their needs for growth and metabolism if they do not receive sufficient nutrition (water, oxygen, and various nutrients), thus leading to aging. Alternatively, aging can be caused by the cytotoxic effects of excessive free radicals, byproducts produced by cells during metabolism. Cells attacked by oxygen free radicals cannot develop according to normal patterns, and long-term accumulation leads to premature aging of cells and even the entire body. Theories about aging are mainly divided into two categories: one is the natural law theory, which holds that human lifespan is determined by genetic factors and that people gradually age until death; the other is the body damage theory. The belief that the body won't age unless subjected to various forms of damage, that cellular aging isn't a natural mutation, but rather a decline in physiological function and the degeneration of important molecules within the body, leading to aging due to impaired function, all depend on external damage. Preventing this damage could potentially prevent aging, or at least delay it. Aging is a process of degeneration across the entire human body; it doesn't just happen in old age, but is a phenomenon that accompanies life throughout its growth. Aging itself is passive, while delaying it is active. Through various supportive measures, including providing essential nutrients, clean air and water, a good living and psychological environment, and a strong sense of self-care, aging can be slowed down. The aging process is accompanied by various diseases; how can we effectively prevent these diseases and slow down the aging process? Antioxidants are the best slow-down agents.

[0003] This composition includes vitamin A, beta-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; Chinese medicinal herbs such as ginseng, astragalus, he shou wu, schisandra, and royal jelly; conditionally essential nutrients such as nucleic acids; and bioactive components such as tea polyphenols, lycopene, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid.

[0004] Vitamin A, also known as retinol, can improve vision and prevent night blindness and cataracts. A deficiency in vitamin A can cause corneal epithelial shedding, thickening, and keratinization, making the cornea opaque and leading to decreased and blurred vision. When vitamin A is sufficient, corneal smoothness increases, and vision improves. Vitamin A enhances immune function by regulating cellular and humoral immunity; therefore, it is also known as the "anti-infection" vitamin. Vitamin A also has antioxidant properties, inhibits tumor growth, enhances the body's resistance, promotes mucopolysaccharide synthesis, and influences bone tissue renewal and development, causing long bones to grow towards both ends. Beta-carotene can be converted into vitamin A in the body through the action of enzymes, thus fulfilling the functions of vitamin A.

[0005] B vitamins participate in the metabolism of proteins, fats, and carbohydrates in the body, working synergistically to perform physiological functions. Deficiency can lead to decreased metabolic function and various diseases. B vitamins include vitamin B1, vitamin B2, niacinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12Vitamins B1, also known as the anti-beriberi factor and anti-neuritis factor, are essential nutrients for life. Vitamin B1 deficiency is known as beriberi, clinically classified into adult beriberi and infant beriberi based on age. Early symptoms of adult beriberi are milder, mainly including fatigue, apathy, poor appetite, nausea, depression, irritability, sadness, heaviness and numbness in the legs, and abnormal electrocardiogram. Severe cases can lead to neuritis and / or heart failure and edema, potentially resulting in sudden death. Vitamin B2, also known as riboflavin, is a component of many important coenzymes in the body, participating in redox reactions in metabolism and playing a vital role in maintaining life. Vitamin B2 deficiency or insufficiency can cause angular cheilitis, glossitis, and cheilitis. Vitamin B2 deficiency is often accompanied by deficiencies in other nutrients, such as affecting niacin and vitamin B6 metabolism, interfering with the absorption, storage, and mobilization of iron in the body, leading to a decrease in stored iron and, in severe cases, iron-deficiency anemia. Nicotinamide, also known as anti-pellagra factor, has the physiological functions of participating in the metabolism of substances and energy in the body, maintaining normal nervous system function, ensuring the synthesis of sex hormones, etc., being related to nucleic acid synthesis, lowering blood cholesterol levels, and being a component of glucose tolerance factor. When deficient, pellagra can occur, with typical symptoms being dermatitis, diarrhea, and dementia. This disease often coexists with beriberi, riboflavin deficiency, and other nutrient deficiency diseases. Pantothenic acid, also known as pantothenic acid, primarily functions as a component of coenzyme A and acyl carrier proteins, playing a role in metabolism. It is widely present in every organism and participates in a wide range of metabolic activities. More than 70 enzymes are known to require pantothenic acid to catalyze various biochemical reactions in the body; otherwise, metabolic disorders will occur. Pantothenic acid deficiency is often accompanied by insufficient intake of the three macronutrients and other vitamins, leading to impaired metabolism. When experiencing unexpected emotional shocks, the body and mind undergo a series of changes, such as increased heart rate, elevated blood pressure, rapid breathing, muscle tension, and elevated blood sugar—a stress response. This stress response involves significant energy expenditure, and pantothenic acid can reduce energy consumption during stress responses; therefore, it is also known as an anti-stress vitamin. Biotin, also known as vitamin B7, works in coordination with other B vitamins to participate in the body's metabolism of substances and energy. Biotin is a coenzyme for many carboxylases in the body, playing an important role in the metabolism of carbohydrates, lipids, proteins, and nucleic acids. It participates in the metabolism of vitamin B12, folic acid, and pantothenic acid; promotes protein synthesis, urea synthesis and excretion; and participates in the synthesis of pancreatic amylase and other digestive enzymes, thus biotin is closely related to the digestive process. It is closely related to nucleic acid synthesis and sex hormone synthesis; deficiency can lead to reproductive dysfunction. Choline is also a B vitamin. In the body, it acts as a precursor to acetylcholine, improving cognitive decline; helping the liver process fat, preventing fatty liver; promoting lipoprotein synthesis; regulating cholesterol levels; maintaining cell membrane structural integrity; and supporting key physiological processes such as DNA methylation.Vitamin B6 acts as a coenzyme for transaminases and amino acid decarboxylases in the body, ensuring the metabolism of amino acids, glycogen, fatty acids, one-carbon units, niacin, and other substances; ensuring the normal metabolic processes of neurotransmitters such as serotonin, taurine, and dopamine; ensuring the synthesis of nucleic acids and proteins and the normal proliferation of cells; and ensuring normal immune function. Deficiency can cause damage to the nervous system. Vitamin B6. 12 Folic acid participates in the synthesis of nucleic acids, choline, and amino acids, as well as the metabolism of fats and sugars. It plays a role in the integrity of bone marrow hematopoiesis, digestive tract epithelial cell function, liver function, and the myelin sheath function of the nervous system. It is an essential vitamin for normal intelligence; deficiency can cause intellectual impairment and nutritional anemia, affecting blood supply to the brain. Folic acid participates in the synthesis of amino acids and nucleic acids and works with vitamin B1. 12 These substances work together to promote cell generation and maturation. A deficiency can prevent normal cells from undergoing mitosis, leading to neurological symptoms such as memory loss, depression, and dementia. Folic acid, vitamin B6, and vitamin B12 are also essential. 12 It can synergistically eliminate homocysteine ​​in the human body.

[0006] Vitamin C, also known as ascorbic acid, is a highly bioactive substance with multiple physiological functions in the body: It is an important free radical scavenger, playing an anti-aging role; it is closely related to collagen, not only softening blood vessels but also purifying the blood and preventing arteriosclerosis; it promotes the absorption of iron and calcium from food; it can reduce folic acid to bioactive tetrahydrofolate, preventing megaloblastic anemia; it participates in the synthesis of neurotransmitters, and a deficiency hinders neurotransmitter formation; it promotes antibody formation, increasing the body's resistance; large doses of vitamin C can alleviate the toxicity of toxic substances such as mercury, lead, arsenic, benzene, and certain drugs and bacterial toxins; vitamin C deficiency or insufficiency can cause subcutaneous bleeding, swollen, bleeding, and ulcerated gums; long-term vitamin C deficiency increases susceptibility to viral colds.

[0007] Vitamin D derivatives refer to a large class of substances containing a cyclopentanenylphenanthrene ring structure and possessing calciferol biological activity, with vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) being the most common. Vitamin D participates in maintaining intracellular and extracellular calcium concentrations and regulating calcium and phosphorus metabolism. Maternal deficiency of vitamin D and calcium can cause bone and teeth development disorders and rickets in offspring. In adults, especially pregnant women, lactating mothers, and the elderly, vitamin D deficiency can lead to demineralization of mature bones, resulting in osteoporosis and osteomalacia.

[0008] Vitamin E is a general term for all chromone derivatives with α-tocopherol biological activity. Among them, α-tocopherol has the highest activity and can eliminate free radicals, delay aging, and prevent macrocytic hemolytic anemia. Vitamin E deficiency or insufficiency can damage the reproductive system and cause irreversible changes in the reproductive epithelium. In men, vitamin E deficiency can lead to testicular atrophy and epithelial cell degeneration.

[0009] Vitamin K is a fat-soluble vitamin that is mainly stored in the liver. Its main physiological functions are: 1. Regulating the synthesis of clotting proteins to ensure the synthesis of prothrombin and other clotting factors in the liver and ensure the operation of the clotting mechanism; 2. Ensuring the health of bone tissue, as the synthesis of three proteins in osteoblasts depends on the participation of vitamin K.

[0010] Calcium is an important macro-element in the human body, playing two main roles: first, it forms hard tissues such as bones and teeth; second, it combines with proteins or forms calcium ions to form substances with specific functions, creating a so-called miscible calcium pool, which maintains a dynamic balance with the calcium in bones and teeth. All cells in the body need calcium to perform their normal functions; calcium deficiency can cause endocrine disorders and malfunction of cell growth regulation.

[0011] Phosphorus is one of the most abundant mineral elements in the human body. An adult's body contains about 600-900g of phosphorus, which accounts for about 1% of body weight. Phosphorus is an important element in the body. It is a component of cell membranes and nucleic acids, and an essential building block of bones and teeth.

[0012] Potassium participates in cellular metabolism and provides suitable conditions for the normal activity of certain enzymes. Its prominent role is to maintain the normal excitability, automaticity, and conductivity of myocardial cells. It also plays an important role in regulating acid-base balance, maintaining osmotic pressure, and maintaining fluid balance. Both hypokalemia and hyperkalemia can cause serious damage to the human body. Mild cases may lead to fatigue and irritability, while severe cases may cause arrhythmia or even death.

[0013] The most important function of magnesium in the human body is to inhibit the production of free radicals, which are the main factors that promote aging. Another function of magnesium is to work with calcium and vitamin D to protect bones. Magnesium deficiency can easily lead to osteoporosis and fractures. In addition, magnesium also has the functions of protecting the heart and preventing diabetes.

[0014] The trace element zinc is fused into biological macromolecular ligands—proteins, nucleic acids, and membranes (mainly membrane proteins)—forming stable metal-containing biological macromolecular complexes—metallothioneins, metallonucleic acid complexes, etc. These substances are known to participate in the synthesis and degradation of carbohydrates, lipids, proteins, and nucleic acids. Zinc-containing enzymes are present in all six major classes of enzymes. Zinc is also a key element for enhancing immune activity. Zinc can promote the conversion of proinsulin to insulin by activating carboxypeptidase B; zinc deficiency inhibits insulin activity in peripheral tissues, leading to abnormal glucose tolerance curves. Recent studies have shown that zinc deficiency can cause impaired nucleic acid and protein synthesis, induce chromosomal aberrations, and enhance the sensitivity of the optic nerve. Zinc is a component of retinol reductase in retinal cells; deficiency directly affects the synthesis and metabolism of retinin by vitamin A, impairing the function of retinal and thus weakening the ability to adapt to low light. Zinc deficiency also affects the color perception of cone cells in the retina.

[0015] Selenium, a trace element, is essential for human embryonic development. It has strong antioxidant properties, protecting the embryo from damage caused by superoxide. Selenium can alleviate or reduce the toxicity caused by mercury, cadmium, lead, arsenic, thallium, nickel, sulfur, etc., and promote the excretion of toxic metals from the body. However, environmental pollution has led to an increasing exposure to these toxic elements year by year, and selenium deficiency can easily lead to Keshan disease. Selenium deficiency can also lead to reduced insulin secretion, decreased glucose tolerance, and decreased antioxidant capacity, thus accelerating human aging and cognitive decline. Selenium is an important trace element for maintaining vision, and selenium deficiency can cause amblyopia.

[0016] The main physiological function of the trace element iron is to participate in the transport of oxygen and tissue respiration in the body as a component of hemoglobin, myoglobin, cytochromes, etc.; it plays a core role in the transport of oxygen and electrons; the structure of catalase contains iron, and hydrogen peroxide is degraded by catalase. Hydrogen peroxide is the most dangerous free radical in the human body; iron deficiency can lead to iron deficiency anemia, the main symptoms of which are physical weakness, weakened memory, and decreased work capacity.

[0017] Chromium is an essential trace element. Only trivalent chromium can be used as a chromium supplement. It can enhance and promote the physiological function of insulin, prevent arteriosclerosis, enhance immune function, and promote growth and development. Chromium deficiency can lead to growth retardation and accelerated aging. Chromium deficiency in the mother can lead to chromium deficiency anemia in the offspring. Timely chromium supplementation can gradually improve the condition.

[0018] Copper mainly functions in the human body in the form of copper-containing metalloenzymes, participating in a series of metabolic functions such as iron utilization, hematopoiesis, phospholipid synthesis, and collagen connective tissue formation.

[0019] Molybdenum is one of the essential trace elements for the human body. It is a constituent element of many enzymes, participates in the utilization of iron, promotes the development and maturation of red blood cells, can prevent anemia, and helps in the metabolism of carbohydrates and fats. It participates in detoxifying the body from toxic aldehydes, eliminating free radicals, and has anti-cancer, anti-aging, immune-enhancing, and anti-caries functions. It can be used to prevent birth defects caused by maternal molybdenum deficiency aggravated by selenium deficiency. Molybdenum has a resistant effect to mercury toxicity, can prevent lead poisoning, and has a synergistic effect with selenium. Molybdenum deficiency can also induce cardiovascular diseases, cancer, and tooth decay.

[0020] Iodine plays a major role in the synthesis of thyroid hormones in the human body. The physiological functions of thyroid hormones include regulating the body's metabolic level, affecting the body's heat production, blood sugar and ketone body levels, muscle and nerve tension, weight, intelligence and sexual function, among other things.

[0021] Fluorine is also an essential trace element for the human body. A normal human body contains approximately 2.6g of fluorine, mainly found in bones and teeth. Appropriate amounts of fluorine are beneficial for the utilization of calcium and phosphorus, promoting bone formation and strengthening bone, and accelerating bone growth. Fluorine can react with hydroxyapatite in tooth enamel to form a hard, acid-resistant protective layer of fluorapatite crystals on the tooth surface, inhibiting glycolysis and reducing the formation of acidic substances, thus preventing tooth decay. However, excessive fluorine intake can cause poisoning.

[0022] Manganese participates in the formation of some enzymes in the human body. It not only participates in the metabolism of sugars and lipids, but also plays a role in the synthesis of proteins, DNA, and RVA. Manganese is an essential trace element for maintaining human sexual function. When men are deficient in manganese, their reproductive function will be impaired, leading to testicular degeneration, reduced sperm count, degenerative changes in seminiferous tubules, and even loss of sexual ability. It can also cause decreased libido, menstrual cycle disorders, and infertility.

[0023] Ginseng is a natural Chinese medicinal herb that can be used in health foods to replenish qi. It has the effects of greatly replenishing vital energy, invigorating the spleen and lungs, promoting body fluid production and quenching thirst, calming the mind and enhancing intelligence. Clinically, it is used for symptoms such as qi deficiency and impending collapse, weak pulse and impending collapse, spleen qi deficiency, lung qi deficiency, thirst due to qi and body fluid depletion, diabetes, deficiency of both qi and blood, and malnourishment of the mind. Modern pharmacological studies have confirmed that: 1. Ginseng enhances both central nervous system excitation and inhibition; 2. Improves cognitive function; 3. Strengthens the heart, resists myocardial ischemia, dilates blood vessels, and has anti-shock effects; 4. Affects the blood and hematopoietic system, improves various blood rheological parameters, increases blood fluidity, inhibits platelet and erythrocyte aggregation, and ginseng extract can promote bone marrow hematopoietic function, significantly increasing the number of erythrocytes, leukocytes, hemoglobin, and nucleated cells in the bone marrow, and promoting the synthesis of RNA, DNA, and proteins in bone marrow cells; 5. Excites the hypothalamic-pituitary-adrenal axis; 6. Excites the hypothalamic-pituitary-sexual axis; 7. Enhances and bidirectionally regulates cyclic nucleotides; 8. Promotes and regulates immune function; 9. Regulates glucose metabolism; 10. Regulates lipid metabolism; 11. Promotes the biosynthesis of proteins, DNA, and RNA, increases cytoplasmic ribosomes, and improves serum protein synthesis rate and albumin and globulin content. 12. Delaying aging: Ginseng has the effect of delaying aging and preventing premature aging. Ginsenosides can significantly prolong the lifespan of animals and cells, inhibit the activity of MAO=B in the brainstem of aged animals, reduce the content of lipofuscin in the myocardium, brain, and liver tissues of aged rats and the content of serum lipid peroxides, increase the activity of superoxide dismutase (SOD), clear excess free radicals in the body and protect biological membranes from free radical damage; in addition, ginseng can also bring the level of norepinephrine in the cerebral cortex of aged animals close to that of young animals. 13. Anti-stress effect: Ginseng can improve the body's non-specific resistance to adverse stimuli (such as various harmful stimuli such as physical, chemical, and biological stimuli), and has an "adaptogenic" effect. For example, ginseng has significant anti-hypoxia, anti-high temperature, anti-low temperature, anti-fatigue, and anti-radiation effects, thus reducing the damage suffered by the body in the stress response. 14. Ginseng also has anti-tumor, liver-protecting, hemostatic, antibacterial, and skeletal muscle and smooth muscle regulation effects.

[0024] Astragalus is a natural Chinese medicinal herb that is both a food and a medicine, used to replenish qi. It has the effects of tonifying qi and raising yang, strengthening the defensive qi and consolidating the exterior, promoting tissue regeneration, and promoting diuresis and reducing edema. Clinically, it is used to treat spleen qi deficiency, qi failing to control blood, qi sinking, spleen and lung qi deficiency, qi and blood deficiency, qi deficiency fever, weakness and excessive sweating, qi deficiency edema, blood stasis and numbness, sequelae of stroke, and diabetes. Ancient Chinese medicine listed it as a superior herb. Modern pharmacological research has confirmed that astragalus has: 1. Enhancing the body's immunity and bidirectionally regulating the body's immune function; 2. Anti-aging function; 3. Improving intelligence. 4. Enhances learning and memory; 5. Anti-fatigue effect; 6. Anti-hypoxia effect; 7. Anti-radiation effect; 8. Anti-cold effect; 9. Anti-mutation effect; 10. Anti-tumor effect; 11. Antibacterial, antiviral, and anti-inflammatory effects; 12. Liver-protecting, kidney-protecting, diuretic, and stomach-protecting effects; 13. Promotes bone growth; 14. Has estrogen-like effects; 15. Has cardiotonic, vasodilatory, and hypotensive effects; 16. Promotes DNA, RNA, and protein synthesis; 17. Regulates blood sugar; 18. Extends the lifespan of animal cells, etc.

[0025] Schisandra chinensis is a natural Chinese medicinal herb that can be used in health foods. It has the effects of astringing the lungs and kidneys, promoting body fluid production and reducing sweating, astringing essence and stopping diarrhea, and calming the mind and soothing the nerves. It is mainly used to treat asthma, chronic cough, thirst due to fluid depletion, spontaneous sweating and night sweats, seminal emission, chronic diarrhea, palpitations, insomnia, and excessive dreaming. Modern pharmacological studies have confirmed that Schisandra chinensis has the following physiological functions: 1. Antioxidant effect: It has a significant protective effect against damage caused by oxygen free radicals and a significant inhibitory effect on peroxidative damage to liver, brain, heart, and kidney cell membranes and micro-lipids caused by carbon tetrachloride, etc.; 2. Anti-aging effect: Feeding 22-month-old rats with Schisandra chinensis for two months can increase SOD activity by 8.4% and decrease plasma lipid peroxides by 30.9%; 3. Liver protection effect: The alcoholic compounds of Schisandra chinensis kernels can protect against carbon tetrachloride. 4. It significantly reduces transaminase levels and protects the liver in mice with liver damage induced by thioacetamide and galactosamine; 5. It improves hypoxia tolerance, reducing myocardial oxygen consumption, increasing myocardial hypoxia tolerance, and slowing heart rate. It also significantly reduces the size of myocardial infarction; 6. It has significant effects on the central nervous system, including sedation, improved sleep, and regulation of nervous system function. It can stimulate spinal reflexes, strengthen the excitation and inhibition processes of conditioned reflexes, balance these processes, and enhance the regulatory function of the cerebral cortex, thereby improving work efficiency and producing an anti-fatigue effect; 7. It has anti-ulcer effects, antagonizing stress-induced gastric ulcers; 8. It also has antimicrobial, anti-allergic, anti-cancer, and bile secretion-promoting effects.

[0026] Prepared Polygonum multiflorum is a natural Chinese medicinal herb used in health foods to replenish blood; it has the effect of nourishing essence and blood; it is mainly used to treat deficiency of essence and blood. Modern pharmacological studies have shown that prepared Polygonum multiflorum has the following effects: 1. Anti-aging: It significantly prolongs the average survival time of elderly quails and extends their lifespan; it can also prolong the growth cycle of diploid cells in fruit flies, making cell growth vigorous and prolonging the lifespan of fruit flies; it has a significant inhibitory effect on the activity of type B monoamine oxidase in the brain and liver tissues of elderly and young mice, and can prevent the thymus of elderly mice from atrophying; it significantly counteracts the decrease in superoxide dismutase (SOD) activity in the brain, liver, blood and other tissues of aged mice, increases the content of superoxide dismutase in the tissues of aged and young mice, and significantly reduces lipofuscin in mouse cardiomyocytes, indicating that prepared Polygonum multiflorum has the following effects: Polygonum multiflorum exerts its anti-aging effects through multiple pathways; 2. It promotes hematopoietic function: processed Polygonum multiflorum can significantly increase the number of bone marrow hematopoietic stem cells, bone marrow granulocyte-monocyte progenitor cells and erythroid progenitor cells, as well as the proportion of peripheral blood reticulocytes; 3. It can increase the level of dopamine receptors in the striatum of the central nervous system of rats and improve the function of the central nervous system of aged rats; 4. It enhances immune function; 5. It significantly lowers blood lipids: it inhibits the increase of total cholesterol, triglycerides, free cholesterol and cholesterol esters in plasma, increases the ratio of high-density lipoprotein cholesterol to total cholesterol in plasma, and can significantly delay the formation and development of atherosclerosis in quail, reduce the lesion rate, and reduce the severity of aortic lesions; 6. It improves the function of the endocrine system; and protects the liver, etc.

[0027] Royal jelly is a bee product that can be used as a raw material for health food. Its physiological functions include: 1. Immune enhancement and regulation: It can promote the production of lymphocyte antibodies, has a promoting effect on lymphocyte proliferation-promoting factors, and can significantly increase thymus mass. 2. Anti-aging effects: By strengthening the body's metabolic function and disease defense capabilities, it can delay aging; promote tissue regeneration, overcome metabolic disorders, and enhance resistance to low pressure, hypoxia, high temperature, infection, poisoning, and organ damage. 3. Promoting brain activation: It overcomes aging disorders in the diencephalon and sexual center of the brain. 4. Overcoming symptoms such as dizziness, nausea, loss of appetite, and constipation caused by autonomic nervous system dysfunction. 5. The salivary gland hormones it contains promote the development of human muscles, bones, teeth, organs, and other tissues, and enhance metabolism. 6. It has certain effects on preventing tumors, lowering blood pressure, improving brain function, improving hepatitis symptoms, alleviating diabetes and gastric ulcer symptoms, preventing arteriosclerosis, increasing red blood cells and platelets, and promoting normal development in premature infants. 7. Anti-radiation effect. After 30 days of X-ray irradiation, the survival rate of rats in the control group was 23.3%, while the survival rate of those orally administered royal jelly was 92%. 8. Antioxidant, hypoxia tolerance, anti-fatigue, and sleep improvement effects. 9. Effects such as reducing age spots and breast enhancement.

[0028] Nucleic acids are one of the basic components of human cells. They play a dominant role in major life phenomena such as growth, development, reproduction, heredity, and variation. Their importance in biological science can be summarized by the statement, "Without nucleic acids, there is no life." When the amount of nucleic acid synthesized in the body cannot meet the needs of normal physiological functions, or when the endogenous nucleic acid synthesis capacity declines, nucleic acids become essential nutrients, hence they are currently called "conditionally essential nutrients." After entering the human body through the digestive tract, nucleic acids (products) are digested and degraded by nucleic acid hydrolysants into various nucleotide monomers, nucleosides, and bases, collectively known as nucleic acid substances, which can then be absorbed and utilized by the human body. Physiological functions: 1. Enhancing immunity and resistance to disease, increasing the number of white blood cells, cytotoxic cells, and neutrophils. 2. Delaying aging. Each cell division causes telomeres at the ends of chromosomes to be depleted. When telomeres are exhausted, cell division stops, and the cell enters the aging phase. Nucleic acids can stimulate the gonads to secrete telomerase, which synthesizes single nucleotide chains to replenish telomeres. This extends the number of cell divisions, thus delaying the aging process of cells. 3. It can regulate endocrine disorders, balancing the hypothalamus-pituitary-gonadal axis and thus alleviating various signs of aging and decline, such as the degeneration of sexual characteristics and atrophy of sexual organs, and relieving or delaying menopausal syndrome. 4. It promotes metabolism and energy supply, eliminates free radicals, mobilizes overall function, and alleviates changes in various organs and systems. 5. It has anti-radiation effects. 6. It plays a regulatory role in the absorption and utilization of the three major nutrients. For lipid metabolism, it can increase the levels of high-density lipoprotein (HDL) and polyunsaturated fatty acids in the blood, and lower cholesterol levels. In cases of low-protein diets, nucleic acid supplementation can promote protein absorption and utilization, eliminating various adverse effects caused by low-protein diets. 7. The decomposition product of RNA, nucleosides, has the effect of dilating peripheral blood vessels. Adenosine triphosphate (AMP) is the energy source for brain metabolism; therefore, many experiments have proven its significant effect on improving vascular dementia. 8. Clinically, nucleic acid preparations such as c-AMP and ATP have long been used to treat visual and hearing impairments. 9. Improves the body's tolerance to environmental changes, significantly combats fatigue, enhances the body's resistance to cold and heat, and promotes the utilization of ingested oxygen. 10. Promotes the development of the reproductive system, etc.

[0029] Lycopene is a carotenoid and a bioactive component used in health food ingredients. However, it does not convert into vitamin A in the human body. Its physiological functions include: 1. Antioxidant: Like other carotenoids, it has the ability to inhibit, scavenge, and capture free peroxide free radicals. Studies have shown that among carotenoids, lycopene has the fastest and strongest ability to scavenge oxygen free radicals, being 5.32 times that of alpha-carotene and 22.73 times that of lutein; 2. Liver protection; 3. Auxiliary tumor inhibition; 4. Lipid regulation; 5. Anti-radiation effect; 6. Anti-aging effect. Lycopene is currently the strongest antioxidant found in nature, with an effect 100 times that of vitamin E. Its ability to quench singlet oxygen and neutralize free radicals is also the strongest, and these two substances are the main causes of human aging; 7. Increased bone density: It promotes bone growth and formation, promotes osteoblast development, and prevents bone loss; 8. Promotes sperm motility, etc.

[0030] Tea polyphenols belong to the polyphenol class of bioactive components and are substances that can be used as raw materials for health foods. Their physiological functions include: 1. Delaying aging and antioxidant effects. According to animal experiments conducted by the Institute of Geriatrics, Chinese Military Medical Academy, tea polyphenols can extend the average lifespan of animals by 1 / 4 to 1 / 3, and the half-life of houseflies by 13.6-15.5 days, an average extension of 36-49% compared to the control group. Tea polyphenols have a strong antioxidant capacity, reacting with excess free radicals in the body to scavenge oxygen free radicals. The maximum scavenging rate reaches 98% and 99%, respectively. Its antioxidant capacity is 18 times stronger than vitamin E, and its antioxidant activity is 2.5 to 4.9 times higher than vitamin E. 2. Inhibiting cholesterol levels in the blood. 3. Inhibiting the rise in blood sugar. 4. Assisting in the inhibition of tumors. 5. Anti-fatigue effects. 6. Protecting the gastric mucosa and inhibiting the activity of Helicobacter pylori. 7. Preventing tooth decay and reducing halitosis. 8. Protecting biological macromolecules. 9. Adsorbing heavy metal ions, causing them to precipitate or be reduced.

[0031] Taurine is a non-essential amino acid and a bioactive component that can be used as a raw material in health foods. Its physiological functions include: 1. Relieving fatigue in those who are overworked, exercise excessively, or are physically exhausted; 2. Maintaining normal brain function and promoting brain development in infants and young children. Insufficient intake can slow down or affect normal brain nerve development, thus impacting intellectual development in infants and young children; 3. Maintaining normal visual function; 4. Antioxidant and anti-aging effects; 5. Enhancing immunity; 6. Lowering blood sugar, participating in insulin secretion, and protecting insulin-producing cells; 7. Participating in endocrine activities and having a series of unique effects on the cardiovascular system, strengthening left ventricular function, increasing myocardial contractility, resisting arrhythmia, preventing congestive heart failure, and lowering blood pressure; 8. Enhancing the permeability of nutrients to cells, neutralizing cytotoxins, reducing the toxicity of secondary acids, and protecting liver cell membranes, thus possessing good choleretic, hepatoprotective, and detoxifying effects; 9. Protective effect against carbon tetrachloride poisoning.

[0032] Lutein is a carotenoid bioactive component with eight isomers, predominantly all-trans, accounting for over 80%. It belongs to the same lutein class as zeaxanthin. From a physiological perspective, both cis and trans lutein have the same physiological effects, while free lutein and lutein esters also provide nutritional supplementation. After absorption, the human body can convert and metabolize lutein esters into lutein, with the ester form exhibiting better stability than the free form. Physiological functions: 1. Lutein is a major component of the macula in the eye and has a preventive effect against age-related macular degeneration. Lutein can be deposited in the lens of the eye. Lutein and zeaxanthin inhibit free radical generation by quenching singlet oxygen, thus protecting and preventing the oxidative denaturation of polyunsaturated fatty acids in retinal cells, thereby inhibiting the development of cataracts. 2. Lutein has an inhibitory effect on various cancers, such as breast cancer, prostate cancer, rectal cancer, colon cancer, and skin cancer. 3. It slows the progression of early arteriosclerosis.

[0033] Zeaxanthin, a carotenoid bioactive component, is mainly found in the endosperm of yellow-grained maize seeds, a member of the Poaceae family. Its physiological functions include: 1. As an antioxidant vitamin, anti-oxidation is its primary physiological function. 2. Protecting eyesight: Zeaxanthin, along with lutein, constitutes a major component of the macula in the eye. The macula, located in the center of the retina and lacking other carotenoids, is the most sensitive and crucial part of the visual system. Damage to the macula can severely impair vision, leading to central vision loss and ultimately blindness. Zeaxanthin, together with lutein, helps prevent age-related macular degeneration (AMD). 3. One cause of cataracts is the oxidation of proteins in the lens of the eye. Zeaxanthin can prevent damage to the eyes from singlet oxygen produced by ultraviolet radiation, preventing the oxidation of proteins and lipids in the lens and reducing the risk of age-related cataracts. 4. Reducing blood lipid oxidation, thereby slowing down arteriosclerosis. 5. Lowering the risk of cancer.

[0034] Chlorophyll is widely found in the chloroplasts of higher plants. Chlorophyll is hydrolyzed in a warm alkaline ethanol aqueous solution. After neutralization with dilute hydrochloric acid, it can be extracted with aqueous ethanol to obtain chlorophyll containing three carboxylic acid groups. Both chlorophyll and chlorophyll are bioactive components that can be used as raw materials for health food. Physiological functions: 1. Anti-mutation effect. Chlorophyll and chlorophyll have strong mutagenic effects, deactivating the activity of mutagenic substances. Chlorophyll has a strong affinity for mutagens, forming complexes that inactivate them. Chlorophyll and chlorophyll can form complexes with the carcinogen Trp-p-2, deactivating its activity, and can also inhibit the metabolic activity of mutagenic substances, promote detoxification metabolism, and control the formation of mutagenic substances. In the human body, chlorophyll can absorb the carcinogen dioxin and excrete it with feces. Dioxin has reproductive toxicity, causing reduced sperm count, decreased sexual function, decreased androgen levels, and feminized behavior in men; in women, it can cause menstrual irregularities, decreased fertility, and miscarriage. Dioxin is teratogenic to many animals. Chlorophyll also has the effect of inhibiting carcinogenic and mutagenic substances such as aflatoxin B1 and benzo[a]pyrene. 2. Protects the gastric mucosa; 3. Has anti-stress effects; 4. Promotes wound healing, etc.

[0035] The human body is a unified whole, carrying out reproduction and physiological metabolism under the regulation of nerves and body fluids. The human body's reproduction and physiological metabolism cannot be separated from essential nutrients, and various essential nutrients need to coordinate with each other to realize the reproductive and physiological functions of the human body as a unified whole.

[0036] The product contains vitamin A, beta-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 Compositions containing folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; traditional Chinese medicines such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum; royal jelly; conditionally essential nutrients such as nucleic acids; and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid as active ingredients are known. However, compositions containing vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 as active ingredients are also known. 12 There are no reports on drug compositions that combine folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, as well as traditional Chinese medicines such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum, royal jelly, conditionally essential nutrients such as nucleic acids, and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid to delay aging and have antioxidant effects.

[0037] Summary of the Invention: To overcome the shortcomings of existing anti-aging and / or antioxidant drugs, the present invention aims to provide a composition comprising ginseng, astragalus, schisandra, processed he shou wu, royal jelly, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid, combined with various vitamins and essential micronutrients such as minerals. The components of ginseng, astragalus, schisandra, processed he shou wu, royal jelly, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid can effectively promote the absorption and utilization of vitamins and minerals, increasing the levels of vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 It contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, which enhance its anti-aging and / or antioxidant effects; it also contains macroelements such as calcium, phosphorus, potassium, and magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, as well as vitamins A, beta-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 It contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, etc., and supplements and enhances the effects of ginseng, astragalus, schisandra, processed he shou wu, royal jelly, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein lipids, zeaxanthin, chlorophyll, chlorophyll, and other components to enhance and regulate immunity, provide antioxidant, anti-aging, anti-mutagenic, and anti-mutagenic effects, eliminate mental and physical fatigue, improve intelligence, promote DNA, RNA, and protein synthesis, promote hematopoiesis, regulate blood sugar and blood lipids, increase bone density, delay aging, and has antioxidant effects. Even with long-term use, there are no side effects. Based on extensive research, the inventors have discovered vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12A novel combination of folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, along with ginseng, astragalus, schisandra, processed he shou wu, royal jelly, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid, offers a synergistic effect in delaying aging and providing antioxidant benefits. Conversely, using vitamin A, beta-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K alone, along with macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, manganese, ginseng, astragalus, schisandra, processed he shou wu, royal jelly, nucleic acids, and lycopene, provides a more comprehensive and effective approach. Other components such as tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll are less effective than this composition. Furthermore, the active ingredients in each component have various health-promoting and nourishing effects on the human body. For example, the dosage of ginseng used in this composition has functions such as greatly replenishing vital energy, invigorating the spleen and lungs, promoting body fluid production and quenching thirst, calming the mind and enhancing intelligence, promoting the synthesis of proteins and nucleic acids, resisting stress, and delaying aging. Astragalus has anti-aging, antioxidant, anti-mutagenic, immune-enhancing and regulating, intelligence-enhancing, and physical-strengthening effects. Schisandra has antioxidant, anti-aging, hypoxia-resistant, sedative, hypnotic, and liver-protective effects, as well as calming and soothing effects. Processed Polygonum multiflorum has functions such as replenishing essence and blood, promoting hematopoietic function, treating deficiency of essence and blood, lowering blood lipids, and anti-aging. Royal jelly has functions such as enhancing... It has effects such as regulating immunity, delaying aging, anti-oxidation, hypoxia tolerance, promoting brain activation, promoting the development of human tissues and organs and metabolism, anti-fatigue, improving sleep, and removing age spots; nucleic acids have the effects of improving immunity, delaying aging, regulating endocrine disorders, scavenging free radicals, treating visual and hearing impairments, and anti-radiation; lycopene and tea polyphenols have strong antioxidant, anti-aging, lipid-lowering, and tumor-inhibiting effects; taurine can eliminate fatigue for those who overuse their brains, exercise, or work, maintain normal physiological functions of the human brain, promote brain development in infants and young children, improve memory, maintain normal visual function, and has antioxidant and anti-aging effects; lutein, lutein lipids, and zeaxanthin all have the effects of scavenging free radicals and preventing age-related macular degeneration. The effects of cataract surgery; chlorophyll and / or chlorophyll acid have strong mutagenic effects, anti-stress effects, wound healing aid effects, and gastric mucosal protection effects; zinc is an essential substance for zinc-containing enzymes among the six major enzymes in the human body and is also a major element for enhancing immune activity; selenium can accelerate the metabolism of excess fat in the body, has strong antioxidant function, prevents heart disease, prevents Keshan disease and Kashin-Beck disease, has anti-cancer function, and alleviates or reduces the toxicity caused by teratogenic and mutagenic substances such as diaphragm, mercury, arsenic, lead, thallium, nickel, and sulfur; iron participates in the transport of oxygen in the body and the process of tissue respiration, and is a major element for preventing iron deficiency anemia; chromium enhances and promotes the physiological function of insulin, enhances immunity, prevents arteriosclerosis, and has anti-aging effects.Trace element copper participates in iron utilization, hematopoiesis, and phospholipid synthesis; trace element molybdenum has anti-cancer, anti-aging, immune-enhancing, and anti-caries functions; trace element iodine can prevent and treat goiter caused by iodine deficiency; trace element fluorine maintains the stability of bone and teeth structure, promotes bone formation and increases bone density, accelerates bone growth, and prevents tooth decay; trace element manganese participates in the synthesis of proteins, DNA, and RNA; vitamin A improves vision and prevents night blindness; vitamin B1 can prevent beriberi and maintain the normal physiological activities of the nervous, digestive, muscular, and circulatory systems; vitamin B2 is an essential vitamin for maintaining healthy skin and eyes; nicotinamide deficiency can cause pellagra; pantothenic acid deficiency can cause metabolic disorders; biotin can prevent and treat gray hair and baldness; choline helps the liver process fat, prevents fatty liver, promotes lipoprotein synthesis, regulates cholesterol levels, maintains cell membrane structural integrity, and supports key physiological processes such as DNA methylation; vitamin B6 can eliminate precancerous cells, enhance immune function, and protect blood vessels; vitamin B... 12 This formula is used to prevent megaloblastic anemia and diseases of the nervous system; folic acid has cardioprotective and anti-cancer effects; vitamin C softens blood vessels, purifies blood, and prevents arteriosclerosis; vitamin E scavenges free radicals and delays aging; potassium maintains the normal excitability, automaticity, and conductivity of myocardial cells; calcium, phosphorus, magnesium, vitamin D, and vitamin K work together to ensure healthy bone tissue; this composition combines multiple antioxidant components with complementary effects, as well as enhancing immunity, antibacterial, antiviral, sedative, analgesic, anti-myocardial ischemia, and anti-shock properties. This invention comprises components that enhance endocrine system function, lower blood sugar and lipids, regulate glucose and lipid metabolism, resist mutations, prevent mutations, inhibit cancer and tumors, promote bone growth, protect the liver and kidneys, and protect the stomach, thus combating pathological aging. It also includes components that enhance central nervous system excitation and inhibition processes, improve cognitive function, regulate immunity, and combat psychological aging such as fatigue, hypoxia, radiation, high temperature, cold, and stress. Furthermore, it incorporates components that promote hematopoiesis, promote the synthesis of human proteins, DNA, and RNA, effectively supplement telomere length, and delay physiological aging. This composition has no incompatibilities, no toxic side effects, and is low in cost, thus constituting this invention.

[0038] This invention provides a pharmaceutical composition for delaying aging and providing antioxidant effects, comprising, as active ingredients, vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12Folic acid, vitamin C, vitamin D, vitamin E, vitamin K and macroelements such as calcium, phosphorus, potassium, magnesium and microelements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, manganese, as well as ginseng, astragalus, schisandra, processed Polygonum multiflorum, royal jelly, nucleic acids, lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll and / or chlorophyll acid, etc.

[0039] The following vitamins are used in this invention: Vitamin B1, Vitamin B2, Nicotinamide, Pantothenic Acid, Biotin, Choline, Vitamin B6, and Vitamin B1. 12 (Vitamin B) 12Folic acid and vitamin C are water-soluble vitamins that do not accumulate in the body; vitamin A, vitamin D, vitamin E, and vitamin K are fat-soluble vitamins; beta-carotene is a precursor to vitamin A and can be converted into vitamin A in the body, and is beneficial and harmless according to the dosage used in this invention; zinc (Zn), selenium (Se), iron (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I), and fluorine (F) are essential trace elements for the human body; manganese (Mn) is a potentially essential trace element for the human body; and calcium (Ca), phosphorus (P), potassium (K), and magnesium (Mg) are essential macroelements for the human body. In this invention, the essential element calcium can be selected from calcium gluconate, calcium acetate, casein calcium, calcium chloride, calcium citrate, calcium malate, calcium citrate-malate, calcium hydrogen phosphate, calcium dihydrogen phosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate, etc.; the essential element phosphorus can be selected from calcium phosphate, calcium hydrogen phosphate, tricalcium phosphate, etc.; and the essential element potassium can be selected from potassium carbonate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium gluconate, potassium sulfate, potassium glycerophosphate, potassium lactate, etc. For the trace element magnesium, options include magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, and magnesium carbonate. For the trace element zinc, options include zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, and zinc monomethionine. For the trace element selenium, options include selenomethionine, selenium methoxybenzyl cyanate, sodium selenite, selenized carrageenan, selenocysteine, selenomethionine, sodium selenate, and selenium yeast. For the trace element iron, options include gluconate... Iron, ferrous lactate, ferric chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric pyrophosphate, ferric ferric chloride, ferrous succinate, ferrous sulfate, etc.; trace element chromium can be selected from chromium trichloride, chromium nicotinate, chromium pyridinecarboxylate, chromium yeast, etc.; trace element copper can be selected from copper carbonate, copper citrate, copper gluconate, copper sulfate, etc.; trace element molybdenum can be selected from ammonium molybdate, sodium molybdate, etc.; trace element iodine can be selected from potassium iodate, etc.; trace element fluorine can be selected from sodium fluoride, fluoride, etc. Potassium and other trace elements, such as manganese, can be obtained from manganese sulfate, manganese gluconate, manganese glycerophosphate, manganese chloride, manganese citrate, etc.; various macro-elements and trace elements, various fat-soluble vitamins and water-soluble vitamins, pharmaceutical raw materials, extracts of traditional Chinese medicines such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum, royal jelly products and their freeze-dried powder, conditionally essential nutrients such as nucleic acids, and bioactive components such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll and chlorophyll acid, etc., all have professional manufacturers and suppliers.

[0040] The pharmaceutical composition of this invention is mainly suitable for middle-aged and elderly people; the dosage of each component refers to the "Chinese Dietary Reference Intakes (2013 Edition)", the standards or regulations formulated by the National Health Commission, the State Drug Administration, and the former Ministry of Health; however, as a drug for the prevention and treatment of diseases, it must comply with the drug registration management principle of "safety, effectiveness, and quality control"; due to the influence of factors such as geology, food chain, dietary habits, and duration of use, the safe, effective, and quality controllable dosage of each component of this composition may vary among different populations. For example, iodine is not required in high-iodine areas, selenium is not required in high-selenium areas, fluorine is not required in high-fluorine areas, molybdenum is not required or is reduced in high-molybdenum areas or for people not receiving long-term parenteral nutrition, and potassium or magnesium is not required or is reduced in normal diets or for people not receiving long-term parenteral nutrition. For individuals who do not consume large amounts of antacids long-term or have renal tubular reabsorption disorders, phosphorus may be omitted or reduced. For individuals with normal diets or who do not receive parenteral nutrition, choline may be omitted or reduced. Based on dietary and lifestyle habits and nutritional health practices, this composition aims to achieve the effects of delaying aging and providing antioxidant benefits. The components of the traditional Chinese medicines ginseng, astragalus, wolfberry, prepared Polygonum multiflorum, royal jelly, conditionally essential nutrients such as nucleic acids, and bioactive ingredients such as lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll can be combined as single or multiple components with various essential micronutrients such as vitamins and minerals. The pharmaceutical composition of this invention is based on suitability for the vast majority of middle-aged and elderly people. To improve the quality of life of middle-aged and elderly people, achieve the goal of delaying aging, and improve the national health level, it is prepared in combination as needed.According to this invention, the effective dosage of ginseng extract, calculated as whole natural medicinal material, is 200-5000 mg / day; the effective dosage of astragalus extract, calculated as whole natural medicinal material, is 330-9980 mg / day; the effective dosage of schisandra extract, calculated as whole natural medicinal material, is 330-6000 mg / day; the effective dosage of processed Polygonum multiflorum extract, calculated as whole natural medicinal material, is 330-18000 mg / day; the effective dosage of royal jelly products or their freeze-dried powder is 50-5000 mg / day; the effective dosage of nucleic acid is 500-1500 mg / day; the effective dosage of lycopene is 10-70 mg / day; the effective dosage of tea polyphenols is 30-300 mg / day; and the effective dosage of taurine is 30-1... 200 mg / day, effective dosage of lutein is 5-20 mg / day, effective dosage of lutein lipids is 10-40 mg / day, effective dosage of zeaxanthin is 10-40 mg / day, effective dosage of chlorophyll and / or chlorophyll acid is 10-200 mg / day, effective dosage of vitamin B1 is 1-19 mg / day, effective dosage of vitamin B2 is 1-19 mg / day, effective dosage of nicotinamide is 6-49 mg / day, effective dosage of pantothenic acid is 3-19 mg / day, effective dosage of biotin is 0.012-0.099 mg / day, effective dosage of choline is 160-1490 mg / day, effective dosage of vitamin B6 is 1-20 mg / day, and vitamin B... 12The effective dosage is 0.0012-0.0099 mg / day; the effective dosage of folic acid is 0.3-0.99 mg / day; the effective dosage of vitamin C is 85-1000 mg / day; the effective dosage of vitamin A and / or β-carotene (in retinol equivalents) is 260-2600 μgRAE / day; the effective dosage of vitamin D is 0.008-0.02 mg / day; and the effective dosage of vitamin E (in α-tocopherol equivalents) is 6-149 mg. The effective dosage of α-TE / day, vitamin K is 0.025-0.099 mg / day, the effective dosage of macro-elements calcium (calculated as elemental calcium) is 260-1200 mg / day, the effective dosage of phosphorus (calculated as elemental phosphorus) is 160-800 mg / day, the effective dosage of potassium (calculated as elemental potassium) is 1210-2600 mg / day, the effective dosage of magnesium (calculated as elemental magnesium) is 130-400 mg / day, the effective dosage of trace element zinc (calculated as elemental zinc) is 6-36 mg / day, the effective dosage of selenium (calculated as elemental selenium) is 0.016-0.39 mg / day, and the effective dosage of iron (calculated as elemental iron) is 9-26 mg / day. The effective dosage of chromium (calculated as elemental chromium) is 0.016-0.148 mg / day, the effective dosage of copper (calculated as elemental copper) is 0.55-7 mg / day, the effective dosage of molybdenum (calculated as elemental molybdenum) is 0.03-0.8 mg / day, the effective dosage of iodine (calculated as elemental iodine) is 0.06-0.6 mg / day, the effective dosage of fluorine (calculated as elemental fluorine) is 0.5-3 mg / day, and the effective dosage of manganese (calculated as elemental manganese) is 2-10 mg / day.

[0041] The compositions of the present invention can be administered or taken directly in the following pharmaceutical formulations, such as oral preparations (e.g., granules, capsules, pills, tablets, dry syrups, liquid preparations), or foods such as solid foods (e.g., biscuits), prepared by mixing with other known additives, such as: carriers, disintegrants, sustained-release agents, excipients, fillers, coating agents, binders, lubricants, antioxidants, coating agents, colorants, flavoring agents, sweeteners, sucrose substitutes, nutritional fortifiers, flavoring agents, surfactants, plasticizers, pH adjusters, fresheners, suspending agents, defoamers, preservatives, thickeners, solubilizers, etc., prepared by conventional methods or added to foods as functional components or additives.

[0042] According to the present invention, vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 are present. 12The product contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese. It also contains the conditionally essential nutrient nucleic acid, royal jelly, and traditional Chinese medicines such as ginseng, astragalus, schisandra, and prepared Polygonum multiflorum. The bioactive components include lycopene, tea polyphenols, taurine, lutein, lutein esters, zeaxanthin, chlorophyll, and / or chlorophyll acid. Each component can be prepared separately, and the preparations of each component can be mixed together or not mixed at the same time before application.

[0043] The advantages of this invention are that the composition scavenges free radicals from multiple systems, multiple links, and multiple targets, eliminates multiple factors that promote aging, and the components have a synergistic effect. It has a significant effect on delaying aging and scavenging free radicals, and also has a variety of health benefits for the user. The raw materials are readily available and the cost is low. The components in the composition have no toxic side effects and no incompatibilities.

[0044] This invention uses essential micronutrients for the human body, namely vitamins and minerals, as the foundation of its anti-aging and antioxidant composition. These are further combined with other functional components that have been proven by modern pharmacological research to have anti-aging and antioxidant properties. The functional components other than the essential micronutrients are primarily composed of ginseng and royal jelly, with other components playing synergistic and adjuvant roles. The components of this composition exert a synergistic effect. The optimized combination of the components other than the essential micronutrients is as follows:

[0045] 1. Ginseng;

[0046] 2. Royal jelly;

[0047] 3. Ginseng and royal jelly;

[0048] 4. Ginseng and Astragalus;

[0049] 5. Ginseng and processed Polygonum multiflorum;

[0050] 6. Ginseng, Astragalus, and processed Polygonum multiflorum;

[0051] 7. Ginseng and Schisandra chinensis;

[0052] 8. Ginseng, taurine;

[0053] 9. Ginseng, nucleic acid;

[0054] 10. Ginseng, taurine, and nucleic acid;

[0055] 11. Ginseng, lycopene;

[0056] 12. Ginseng, tea polyphenols;

[0057] 13. Ginseng, lutein;

[0058] 14. Ginseng, zeaxanthin;

[0059] 15. Ginseng, chlorophyll;

[0060] 16. Royal jelly and astragalus;

[0061] 17. Royal jelly, processed Polygonum multiflorum;

[0062] 18. Royal jelly, astragalus, and prepared Polygonum multiflorum;

[0063] 19. Royal jelly, Schisandra chinensis;

[0064] 20. Royal jelly, taurine;

[0065] 21. Royal jelly, nucleic acid;

[0066] 22. Royal jelly, taurine, nucleic acid;

[0067] 23. Royal jelly, lycopene;

[0068] 24. Royal jelly, tea polyphenols;

[0069] 25. Royal jelly, lutein;

[0070] 26. Royal jelly, zeaxanthin;

[0071] 27. Royal jelly, lutein, zeaxanthin;

[0072] 28. Royal jelly, chlorophyll;

[0073] 29. Ginseng, royal jelly, and astragalus;

[0074] 30. Ginseng, royal jelly, and processed Polygonum multiflorum;

[0075] 31. Ginseng, royal jelly, astragalus, and prepared Polygonum multiflorum;

[0076] 32. Ginseng, royal jelly, and schisandra chinensis;

[0077] 33. Ginseng, royal jelly, taurine;

[0078] 34. Ginseng, royal jelly, and nucleic acid;

[0079] 35. Ginseng, royal jelly, taurine, and nucleic acid;

[0080] 36. Ginseng, royal jelly, lycopene;

[0081] 37. Ginseng, royal jelly, and tea polyphenols;

[0082] 38. Ginseng, royal jelly, lutein;

[0083] 39. Ginseng, royal jelly, zeaxanthin;

[0084] 40. Ginseng, royal jelly, lutein, zeaxanthin;

[0085] 41. Ginseng, royal jelly, chlorophyll.

[0086] Detailed Implementation: The present invention will be described in detail below with reference to the embodiments and test embodiments and their effects.

[0087] Example 1:

[0088]

[0089]

[0090]

[0091] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium aluminosilicate, and flavoring agents. The resulting mixture is then made into 3 packets of granules. Take one packet three times daily.

[0092] Example 2:

[0093]

[0094]

[0095]

[0096] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium aluminosilicate, and flavoring agents. The resulting mixture is then made into 9 granular packets. Take 3 packets 3 times a day, with a 1-day interval between doses.

[0097] Example 3:

[0098]

[0099]

[0100] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to make 3 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 1 tablet 3 times a day.

[0101] Example 4:

[0102]

[0103]

[0104] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to make 4 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 2 tablets twice a day.

[0105] Example 5:

[0106]

[0107]

[0108] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to make 3 tablets, which are then coated with a premixed film coating (gastric-soluble type). Take 1 tablet 3 times a day.

[0109] Example 6:

[0110]

[0111]

[0112] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate, triethyl citrate, polysorbate 80 and flavoring agent to make 2 tablets, which are then coated with a film-coating premix (gastric-soluble type). Take 1 tablet twice a day.

[0113] Example 7:

[0114]

[0115]

[0116]

[0117] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium stearate, and flavoring agents, and the resulting mixture is then made into 3 tablets. Take one tablet three times daily.

[0118] Example 8:

[0119]

[0120]

[0121] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium stearate, and flavoring agents. The resulting mixture is then made into 3 packets of granules. Take one packet three times daily.

[0122] Example 9: The following are four batches of experiments using the composition of the present invention. Each batch of experiments included two items: the first item was the effect of the test composition (TP) on the lifespan of houseflies, and the second item was the effect of the test composition (TP) on SOD and lipofuscin in the brain of houseflies. Each experiment was divided into three groups: the first group was the control group, the second group was the low-dose group, and the third group was the high-dose group. The sample size of houseflies in each group was 200, with half males and half females. Regarding the effect on the lifespan of houseflies, the test composition was administered 10 days after separation from the nest. The number of surviving houseflies and the number of dead houseflies were recorded daily until all houseflies died. The half-life was calculated based on the statistical results of male houseflies, and the average lifespan was calculated based on the statistical results of female houseflies. The effect on SOD and lipofuscin in the brain of houseflies was tested three weeks after separation from the nest. The test compositions were as follows: 1. The first batch consisted of essential micronutrients (vitamins and minerals) plus ginseng, and the experimental results are shown in Tables 1 and 2; the second batch consisted of essential micronutrients (vitamins and minerals) plus ginseng and royal jelly, and the experimental results are shown in Tables 3 and 4; the third batch consisted of essential micronutrients (vitamins and minerals) plus royal jelly, and the experimental results are shown in Tables 5 and 6; the fourth batch consisted of essential micronutrients (vitamins and minerals) plus ginseng and astragalus, and the experimental results are shown in Tables 7 and 8.

[0123] Appendix 1 compares the experimental results of the combination of essential micronutrients (vitamins and minerals) plus ginseng (TP) on the median mortality time and average lifespan of houseflies.

[0124]

[0125]

[0126] Appendix Table 2 compares the experimental results of the combination of essential micronutrients (vitamins and minerals) plus ginseng (TP) on SOD and lipofuscin in the brain of houseflies.

[0127]

[0128] The experimental results in Appendix Table 1 show that the combination of essential micronutrients (vitamins and minerals) and ginseng (TP) significantly extended the median mortality time and average lifespan of houseflies compared with the control group.

[0129] The experimental results in Appendix Table 2 show that, compared with the control group, the combination of essential micronutrients (vitamins and minerals) plus ginseng (TP) significantly increased SOD in the brain of houseflies and significantly reduced lipofuscin in the brain of houseflies.

[0130] Appendix Table 3 compares the experimental results of the effects of a combination of essential micronutrients (vitamins and minerals) plus ginseng and royal jelly (TP) on the median mortality time and average lifespan of houseflies.

[0131]

[0132] Appendix Table 4 compares the experimental results of the combination of essential micronutrients (vitamins and minerals) plus ginseng and royal jelly (TP) on SOD and lipofuscin in the brain of houseflies.

[0133]

[0134] The experimental results in Appendix 3 show that the combination of essential micronutrients (vitamins and minerals) plus ginseng and royal jelly (TP) significantly extended the median mortality time and average lifespan of houseflies compared with the control group.

[0135] The experimental results in Appendix Table 4 show that, compared with the control group, the combination of essential micronutrients (vitamins and minerals) plus ginseng and royal jelly (TP) significantly increased SOD in the brain of houseflies and significantly reduced lipofuscin in the brain of houseflies.

[0136] Appendix Table 5 compares the experimental results of the effects of a combination of essential micronutrients (vitamins and minerals) and royal jelly (TP) on the median mortality time and average lifespan of houseflies.

[0137]

[0138] Appendix Table 6 compares the experimental results of the combination of essential micronutrients (vitamins and minerals) and royal jelly (TP) on SOD and lipofuscin in the brain of houseflies.

[0139]

[0140] The experimental results in Appendix 5 show that the combination of essential micronutrients (vitamins and minerals) and royal jelly (TP) significantly extended the median mortality time and average lifespan of houseflies compared with the control group.

[0141] The experimental results in Appendix Table 6 show that, compared with the control group, the combination of essential micronutrients (vitamins and minerals) and royal jelly (TP) significantly increased SOD in the brain of houseflies and significantly reduced lipofuscin in the brain of houseflies.

[0142] Appendix Table 7 compares the experimental results of the effects of a combination of essential micronutrients (vitamins and minerals) plus ginseng and astragalus (TP) on the median mortality time and average lifespan of houseflies.

[0143]

[0144] Appendix Table 8 compares the experimental results of the combination of essential micronutrients (vitamins and minerals) plus ginseng and astragalus (TP) on SOD and lipofuscin in the brain of houseflies.

[0145]

[0146] The experimental results in Appendix 7 show that the combination of essential micronutrients (vitamins and minerals) plus ginseng and astragalus (TP) significantly extended the median mortality time and average lifespan of houseflies compared with the control group.

[0147] The experimental results in Appendix Table 8 show that the combination of essential micronutrients (vitamins and minerals) plus ginseng and astragalus (TP) significantly increased SOD in the brain of houseflies and significantly reduced lipofuscin in the brain of houseflies compared with the control group.

Claims

1. A pharmaceutical composition for delaying aging and possessing antioxidant properties, characterized in that, It is made from the following raw materials in the following weight ratio:

2. A pharmaceutical composition for delaying aging and possessing antioxidant properties, characterized in that, It is made from the following raw materials in the following weight ratio:

3. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

4. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

5. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 2, characterized in that, It is made from the following raw materials in the following weight ratio:

6. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

7. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

8. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

9. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 2, characterized in that, It is made from the following raw materials in the following weight ratio:

10. The pharmaceutical composition for delaying aging and possessing antioxidant properties according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

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