A traditional Chinese medicine composition containing patrinia for treating oviduct inflammation of chicken and its use

Abstract

This invention discloses a traditional Chinese medicine composition containing *Patrinia scabiosifolia* for the prevention and treatment of oviductitis in chickens, and its usage. The composition comprises the following ingredients in parts by weight: 55-65 grams of *Patrinia scabiosifolia*, 5-7 grams of *Forsythia suspensa*, 5-7 grams of *Lonicera japonica* vine, and 5-7 grams of *Astragalus membranaceus*. These ingredients are pulverized, sieved, and mixed thoroughly to obtain the traditional Chinese medicine composition containing *Patrinia scabiosifolia* for the prevention and treatment of oviductitis in chickens. This composition is mixed into the feed at a rate of 2.6 grams per chicken for 5 consecutive days. This traditional Chinese medicine composition containing *Patrinia scabiosifolia* for the prevention and treatment of oviductitis in chickens, and its usage, are prepared from natural Chinese herbal medicines. They have advantages such as long-lasting effect, no residue, and minimal irritation to the animal body. Furthermore, the formulation of this traditional Chinese medicine composition is precise and can significantly prevent and treat oviductitis in laying hens. This traditional Chinese medicine composition is convenient to use, uses readily available raw materials, is inexpensive, and is environmentally friendly.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese veterinary medicine technology, and in particular to a traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens and its usage. Background Technology

[0002] In poultry farming, oviductitis is a common disease in laying hens, arguably the most serious poultry disease threatening the industry. Oviductitis can occur in any breed and age group. Its causes are complex, making it one of the most prevalent diseases affecting the poultry industry. Clinically, it is characterized by oophoritis, oviductitis, and peritonitis. While its clinical manifestations are diverse, they all easily lead to a decrease in egg production and the production of inferior eggs, such as thin-shelled eggs, soft-shelled eggs, rough-shelled eggs, deformed eggs, white-shelled eggs, and small eggs. The pathogen is one or more of the following mixed infections: bacteria, mycoplasma, anaerobic bacteria, and trichomonas. Clinically, it is characterized by inflammation of the ovaries, fallopian tubes, and peritonum. In severe cases, the follicles become deformed, congested, and hemorrhaged, turning reddish-brown or grayish-brown, and may even rupture, releasing yolk-like fluid into the abdominal cavity. This fluid has a foul odor. Sometimes, the follicles shrink, become irregularly shaped, and turn golden yellow or brown without luster. If the condition persists for a while, intestinal adhesions may occur, and the fallopian tubes may contain yellowish-white, cheesy material.

[0003] Traditional Chinese medicine (TCM) treatment for oviductitis in laying hens often employs herbs that clear heat and detoxify, and replenish blood and qi. Commonly used veterinary medicines include Sihuang Zhili Granules, Baitouweng Oral Liquid, and Bailong Granules. However, in clinical practice, these have been found to be ineffective in treating oviductitis in laying hens, with the condition prone to recurrence. TCM powders such as Jidan San, Danji Bao, and Yimu Zengdan San, which are warming and tonifying powders, also suffer from poor clinical efficacy (low cure rate and slow onset of action) and low cost-effectiveness in practical poultry farming applications. Summary of the Invention

[0004] To address the aforementioned shortcomings in the existing technology, this invention provides a traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens, and its usage. This composition mainly consists of Patrinia scabiosifolia, Forsythia suspensa, Lonicera japonica, and Astragalus membranaceus, and has produced unexpected effects in preventing and treating oviductitis in laying hens caused by various reasons.

[0005] To achieve the above-mentioned objectives, the technical solution adopted by this invention is as follows:

[0006] A traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens comprises the following substances in parts by weight: 55-65 parts of Patrinia scabiosifolia, 5-7 parts of Forsythia suspensa, 5-7 parts of Lonicera japonica, and 5-7 parts of Astragalus membranaceus. The traditional Chinese medicine composition is pulverized, sieved, and extracted to obtain the traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens.

[0007] Furthermore, the pulverizing, sieving, and extraction process includes: using supercritical extraction technology: pulverizing and sieving the Chinese herbal composition, adding it to a supercritical extraction device for extraction to obtain essential oil components, placing the residue after essential oil extraction in the same extraction tank, and refluxing with water equivalent to 6 to 12 times the mass of the herbal material 1 to 3 times, each time for 1 to 4 hours, combining the extracts, and concentrating under reduced pressure to an extract with a relative density of 1.05 to 1.25 at a temperature of 55 to 60°C to obtain an aqueous extract.

[0008] Furthermore, the purslane, forsythia, honeysuckle vine, and astragalus are pulverized and passed through a 60-80 mesh sieve.

[0009] Furthermore, the extraction conditions are: extraction vessel pressure 20-30 MPa, temperature 50-60°C, and desorption vessel pressure 6-8 MPa, temperature 50-60°C.

[0010] Furthermore, it includes the following substances in parts by weight: 60 parts of Patrinia scabiosifolia, 6 parts of Forsythia suspensa, 6 parts of Lonicera japonica, and 6 parts of Astragalus membranaceus.

[0011] Furthermore, the following substances are included by weight: 60 parts of Patrinia scabiosifolia, 6 parts of Forsythia suspensa, 6 parts of Lonicera japonica, and 6 parts of Astragalus membranaceus.

[0012] The method of using a traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens: Crush and mix the traditional Chinese medicine composition to make a powder, or make the essential oil components and water extract into a soluble powder, oral liquid or granules. Feed each chicken 2.6 grams per day for 5 consecutive days.

[0013] The beneficial effects of this invention are as follows:

[0014] This invention discloses a traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens, and its usage. Prepared from natural Chinese herbal medicines, it has advantages such as long-lasting effect, no residue, and minimal irritation to the animal body. Furthermore, the formulation of this invention's traditional Chinese medicine composition is precise, significantly preventing and treating oviductitis in laying hens. This composition is convenient to use, uses readily available raw materials, is inexpensive, and is environmentally friendly. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the traditional Chinese medicine composition of Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens according to the present invention. Detailed Implementation

[0016] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

[0017] Example 1

[0018] like Figure 1As shown, a traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens is prepared as follows: Patrinia scabiosifolia 55g, Forsythia suspensa 5g, Lonicera japonica 5g and Astragalus membranaceus 5g. Take Patrinia scabiosifolia 55g, Forsythia suspensa 5g, Lonicera japonica 5g and Astragalus membranaceus 5g, take the above-mentioned medicinal materials, pulverize them separately, sieve them through a 60-mesh sieve, mix them evenly to obtain a powder.

[0019] Example 2

[0020] Formula: 55g of Patrinia scabiosaefolia, 5g of Forsythia suspensa, 5g of Lonicera japonica, and 5g of Astragalus membranaceus. Take 55g of Patrinia scabiosaefolia, 5g of Forsythia suspensa, 5g of Lonicera japonica, and 5g of Astragalus membranaceus. Grind the above herbs, sieve through a 60-mesh sieve, and add them to a supercritical fluid extraction device for extraction to obtain essential oil components. Place the residue after essential oil extraction in the same extraction tank and reflux with water equivalent to 6 times the weight of the herbs once, for 1 hour each time. Combine the extracts and concentrate under reduced pressure to a relative density of 1.05 at 55℃ to obtain an aqueous extract. Coat the essential oil components with β-cyclodextrin, dry, and pulverize to obtain an essential oil coating. Dry the aqueous extract at 70℃ and pulverize to obtain a dry extract powder. The extraction vessel pressure is 20 MPa and the temperature is 50℃, and the desorption vessel pressure is 6 MPa and the temperature is 50℃. Mix the essential oil coating, dry extract powder, and anhydrous glucose evenly to obtain a soluble powder.

[0021] Example 3

[0022] Formula: 60g of Patrinia scabiosaefolia, 6g of Forsythia suspensa, 6g of Lonicera japonica, and 6g of Astragalus membranaceus. Take 60g of Patrinia scabiosaefolia, 6g of Forsythia suspensa, 6g of Lonicera japonica, and 6g of Astragalus membranaceus. Crush the above herbs, sieve through a 60-mesh sieve, and add them to a supercritical fluid extraction device for extraction to obtain essential oil components. Place the residue after essential oil extraction in the same extraction tank and reflux with water equivalent to 10 times the weight of the herbs three times, 3 hours each time. Combine the extracts and concentrate under reduced pressure to a relative density of 1.2 at 60℃ to obtain an aqueous extract. The extraction vessel pressure is 25 MPa and the temperature is 55℃, and the desorption vessel pressure is 7 MPa and the temperature is 58℃. Add an appropriate amount of water (80% of the specified volume) to the obtained essential oil components, aqueous extract, and co-solvent, stir to dissolve, add 3‰ sodium benzoate and potassium sorbate, stir to dissolve, add water to the specified volume, mix well, bottle, and sterilize to obtain the oral liquid.

[0023] Example 4

[0024] Formula: 65g of Patrinia scabiosaefolia, 7g of Forsythia suspensa, 7g of Lonicera japonica, and 7g of Astragalus membranaceus. Take 65g of Patrinia scabiosaefolia, 7g of Forsythia suspensa, 7g of Lonicera japonica, and 7g of Astragalus membranaceus. Grind the above herbs, sieve through an 80-mesh sieve, and add them to a supercritical fluid extraction device for extraction to obtain essential oil components. Place the residue after essential oil extraction in the same extraction tank and reflux with water equivalent to 12 times the weight of the herbs three times, 4 hours each time. Combine the extracts and concentrate under reduced pressure to an extract with a relative density of 1.25 at 60℃ to obtain an aqueous extract. The extraction vessel pressure is 30 MPa and the temperature is 60℃, and the desorption vessel pressure is 8 MPa and the temperature is 60℃. Coat the essential oil components with β-cyclodextrin, dry, and pulverize to obtain the coated essential oil. Spray dry the aqueous extract and pulverize to obtain a dry extract powder. The essential oil coating, extract powder, sucrose powder, and dextrin are mixed evenly, and 60% ethanol is used as a binder to form granules. The granules are then dried, sorted, and packaged to obtain the final product.

[0025] Example 5

[0026] Clinical trial of treatment for oviductitis in laying hens

[0027] Experimental animals: 10,500 chickens, 350 days old, raised by an individual farmer in Taoyuan Town, Suining County, Xuzhou City. The egg production rate dropped from 93% to 90%. The eggshells turned white, the number of blood-spotted eggs increased, the eggshells became thinner and more brittle, and 240 eggs broke per day. The diagnosis was oviductitis in chickens.

[0028] In the experiment, the chicken houses were divided into four rows, with about 2,600 chickens in each row. The Chinese medicine compositions from Examples 1 to 4 were mixed into the feed of each row, and each row was fed 6,760 grams per day for five consecutive days.

[0029] Experimental statistical indicators and egg classification standards:

[0030] Qualified eggs: smooth surface, no obvious pits (diameter less than 1mm), no roughness, shiny yellowish-brown color, and intact eggshell quality;

[0031] Unqualified eggs: Sandy-shelled eggs (eggs with rough shells, irregular bumps, or eggs that are broken or deformed due to thin shells); Blood-spotted eggs (eggs with obvious red or dark red blood spots on the shell); Soft-shelled eggs (eggs whose shells have not been calcified before the light of day); Cracked eggs (eggs with obviously broken shells); and other abnormal eggs.

[0032] Daily egg production rate: Daily egg production rate % = Number of eggs produced per day / Number of laying hens * 100;

[0033] Daily defective egg rate: Daily defective egg rate % = Number of defective eggs per day / Total number of eggs produced per day * 100;

[0034] After medication, the egg production rate recovered to 93%, the eggshell quality recovered, and about 60 eggs broke per day, indicating that the use of the herbal composition of this invention can significantly improve the unqualified egg production rate of laying hens caused by oviductitis.

[0035] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for preventing and treating oviduct inflammation in chicken, comprising Herba Patriniae, characterized in that, The following substances are included in parts by weight: 55-65 parts of Patrinia scabiosifolia, 5-7 parts of Forsythia suspensa, 5-7 parts of Lonicera japonica, and 5-7 parts of Astragalus membranaceus. Take 55-65 parts of Patrinia scabiosifolia, 5-7 parts of Forsythia suspensa, 5-7 parts of Lonicera japonica, and 5-7 parts of Astragalus membranaceus, pulverize, sieve, and extract the traditional Chinese medicine composition to obtain the traditional Chinese medicine composition containing Patrinia scabiosifolia for the prevention and treatment of oviductitis in chickens.

2. The Chinese medicine composition for preventing and treating salpingitis of chicken containing Herba Patriniae according to claim 1, characterized in that: The pulverizing, sieving, and extraction process includes: using supercritical extraction technology: pulverizing and sieving the Chinese herbal composition, adding it to a supercritical extraction device for extraction to obtain essential oil components, placing the residue after essential oil extraction in the same extraction tank, and refluxing with water equivalent to 6 to 12 times the mass of the herbal material 1 to 3 times, each time for 1 to 4 hours, combining the extracts, and concentrating under reduced pressure to an extract with a relative density of 1.05 to 1.25 at a temperature of 55 to 60°C to obtain an aqueous extract.

3. The Chinese medicine composition for preventing and treating salpingitis of chicken containing Herba Patriniae according to claim 2, characterized in that: The herbs, including Patrinia scabiosifolia, Forsythia suspensa, Lonicera japonica, and Astragalus membranaceus, were pulverized and passed through a 60-80 mesh sieve.

4. The Chinese medicine composition for preventing and treating salpingitis of chicken containing Herba Patriniae according to claim 2, characterized in that: The extraction conditions are as follows: extraction vessel pressure 20-30 MPa, temperature 50-60℃, and desorption vessel pressure 6-8 MPa, temperature 50-60℃.

5. The Chinese medicine composition for preventing and treating salpingitis of chicken containing Herba Patriniae according to claim 1, characterized in that: The following ingredients are included in parts by weight: 60 parts of Patrinia scabiosifolia, 6 parts of Forsythia suspensa, 6 parts of Lonicera japonica, and 6 parts of Astragalus membranaceus.

6. The Chinese medicine composition for preventing and treating salpingitis of chicken containing Herba Patriniae according to claim 1, characterized in that: The following ingredients are included by weight: 60 parts of Patrinia scabiosifolia, 6 parts of Forsythia suspensa, 6 parts of Lonicera japonica, and 6 parts of Astragalus membranaceus.

7. A use of a Chinese medicine composition containing Patrinia for preventing and treating oviduct inflammation in hens, comprising the Chinese medicine composition containing Patrinia for preventing and treating oviduct inflammation in hens according to any one of claims 1 to 6, characterized in that: The Chinese herbal composition is pulverized and mixed to make a powder, or the essential oil components and water extracts are made into soluble powder, oral liquid or granules. Each chicken is fed 2.6 grams per day for 5 consecutive days.

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