A blood purification system and aspiration and dispensing method

Abstract

This invention relates to the field of medical device technology and discloses a blood purification system and a method for aspirating and pushing liquid. The system includes a first balance chamber, a second balance chamber, an inlet, an outlet, a supply port, and a return port. The first balance chamber includes chambers A and B, and the second balance chamber includes chambers C and D. The inlet and supply port are connected to chambers B and D, respectively, while the outlet and return port are connected to chambers A and C. A first pump body is installed between the inlet and valves Bi and Di. A valve E is installed between the outlet and valves Ao and Co. A valve F is installed between the supply port and valves Bo and Do. A valve G and a second pump body are sequentially installed between the return port and valves Ai and Ci. This invention utilizes the balance chamber and adds valve E, which changes the working mode of the balance chamber. In this working mode, power is provided by the first and second pump bodies, eliminating the need for an ultrafiltration pump and significantly improving the efficiency of pushing and aspirating liquid.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a blood purification system and a method for aspirating and dispensing fluid. Background Technology

[0002] In existing hemodialysis equipment, fresh dialysate flows into the dialyzer's inlet after passing through the balance chamber, while post-dialysis waste fluid flows from the dialyzer's outlet into the balance chamber. The balance chamber module of the hemodialysis equipment includes two balance chambers, each separated into two compartments by a diaphragm. One balance chamber's two compartments are used for preparing dialysate and discharging waste fluid, respectively. The other balance chamber's two compartments are used for supplying dialysate to the dialyzer and collecting dialyzer waste fluid, respectively. The two balance chambers alternately switch functions. Because the volume of each balance chamber is fixed, the two compartments of each balance chamber always maintain a "one in, one out" balance, thus establishing equilibrium. When the ultrafiltration pump is running, the post-dialysis waste fluid branches off and flows to the ultrafiltration pump before reaching the balance chamber. Since the ultrafiltration pump captures a volume V of liquid, and the volume of post-dialysis waste fluid flowing into the balance chamber must equal the volume of fresh fluid flowing out, the patient's blood flowing through the dialyzer's blood chamber will lose a volume V of water, thereby achieving the machine's ultrafiltration goal for the patient.

[0003] In existing technologies, during aspiration, the balance chamber operates as described above, while the ultrafiltration pump rotates forward to draw fluid from the extracorporeal blood tubing (arterial or venous tubing) into the dialyzer. The fluid is then drawn from the dialyzer's blood chamber to the dialysate chamber and finally to the machine's water circuit. The ultrafiltration pump measures the aspirated volume to achieve the target aspirated volume. During push operation, the balance chamber remains in the same mode as described above, while the ultrafiltration pump rotates in reverse, pushing the fluid from the machine's water circuit into the dialyzer and across the membrane into the blood chamber. This pushes the fluid into the extracorporeal blood tubing connected to the dialyzer, and the ultrafiltration pump measures the push volume to achieve the target push volume. In the above liquid pushing and aspiration schemes, the maximum rate that the dialysis equipment can achieve for liquid aspiration and pushing is determined by the maximum rate of the ultrafiltration pump. However, in order to accurately measure the amount of liquid transferred, the ultrafiltration pump generally adopts a short-stroke plunger pump, and the amount of liquid that can be transferred in a single stroke of the plunger is less than 1 ml. This results in a low maximum flow rate of the ultrafiltration pump, so the efficiency of using the ultrafiltration pump for liquid aspiration and pushing is low. Summary of the Invention

[0004] The technical problem to be solved by this invention is: how to improve the fluid pushing rate and fluid aspiration rate during dialysis. To solve the above technical problem, this invention provides a blood purification system, including a first balance chamber, a second balance chamber, an inlet, an outlet, a supply port, and a return port. The first balance chamber includes chamber A and chamber B, and the second balance chamber includes chamber C and chamber D. The inlet and the supply port are connected to chamber B and chamber D, respectively. The outlet and the return port are connected to chamber A and chamber C, respectively. A valve Ai is provided between chamber A and the return port, and a valve Ao is provided between chamber A and the outlet. A valve Bi is provided between chamber B and the inlet, and a valve Bo is provided between chamber B and the supply port. A valve Ci is provided between chamber C and the return port, and a valve Co is provided between chamber C and the outlet. A valve Di is provided between chamber D and the inlet, and a valve Do is provided between chamber D and the supply port. A first pump body is provided between the inlet and valves Bi and Di; valve E is provided between the outlet and valves Ao and Co; valve F is provided between the supply port and valves Bo and Do; and valve G and a second pump body are provided sequentially between the return port and valves Ai and Ci.

[0005] Preferably, it further includes a second bypass and a third pump body, wherein the valve G is connected to the third pump body, and the third pump body is connected to the first bypass; One end of the second bypass is connected to valve F, valve Bo, and valve Do, and the other end of the second bypass is connected to valve G and the third pump body. The second bypass is equipped with valve H.

[0006] The present invention also provides a method for injecting fluid using the blood purification system described above, comprising the following steps: S1. Close valves E and G, open valve F, and start the first pump body; S2, connect the first pump body to chamber B, connect chamber A to chamber C, and connect chamber D to valve F; S3. Connect the first pump body to chamber D, connect chamber C to chamber A, and connect chamber B to valve F; S4. Repeatedly switch between steps S2 and S3 until the target volume of the liquid is reached.

[0007] Preferably, in step S2, valves Bi, Ao, Co, and Do are opened sequentially, while valves Ai, Bo, Ci, and Di are closed simultaneously.

[0008] Preferably, in step S3, valves Di, Co, Ao, and Bo are opened sequentially, while valves Ai, Bi, Ci, and Do are closed simultaneously.

[0009] Preferably, the target volume of the liquid pusher = the volume of the balance chamber V * the number of liquid pusher chambers = the liquid volume per unit jog of the valve * the total number of jogs of the valve body; Wherein, the total number of times the valve body pushes the liquid is 1 / 2 the total number of times the valve Ao or the valve Co is 1 / 2; The volume of liquid per unit jog of the valve = the volume of the balance chamber V / the total number of jogs when the valve body passes through a volume V of liquid; Jogging speed = Unit jogging liquid volume / Jogging interval duration.

[0010] This invention provides a liquid aspiration method using the blood purification system described above, comprising the following steps: S5. Open valves E and G, close valve F, and open the second pump body; S6. Connect the second pump body to the C chamber, connect the D chamber to the B chamber, and connect the A chamber to the liquid outlet; S7. Connect the second pump body to chamber A, connect chamber B and chamber D, and connect chamber C to the liquid outlet; S8. Repeatedly switch between steps S6 and S7 until the target volume of liquid is reached.

[0011] Preferably, in step S6, valve Ci, valve Do, valve Bo and valve Ao are opened sequentially, and valve Ai, valve Bi, valve Co and valve Di are closed simultaneously.

[0012] Preferably, in step S7, valves Ai, Bo, Do, and Co are opened sequentially, while valves Ci, Di, Bi, and Ao are closed simultaneously.

[0013] Preferably, the target volume of liquid aspiration = volume of the balance chamber V * number of aspiration chambers = liquid volume per unit jog of the valve * total number of jogs of the valve body; Wherein, the total number of times the valve body draws liquid is 1 / 2 the total number of times the valve Bo or the valve Do is 1 / 2; The volume of liquid per unit jog of the valve = the volume of the balance chamber V / the total number of jogs when the valve body passes through a volume V of liquid; Jogging speed = Unit jogging liquid volume / Jogging interval duration.

[0014] Compared with the prior art, the blood purification system and liquid aspiration method and liquid pushing method provided in this embodiment of the invention have the following advantages: In this embodiment, an additional valve E is installed at the outlet, and a first pump body is installed at the inlet. During the pushing phase, the first pump body located at the inlet provides power and controls the opening and closing of relevant valves to change the working mode of the balance chamber. This allows the liquid at the inlet to be quickly pushed towards chamber B or D, which in turn drives the liquid in chamber A or C to flow towards chamber C or A, and then drives the liquid in chamber D or B towards the supply port, thus achieving the pushing phase. During the suction phase, the opening and closing of relevant valves is controlled to change the working mode of the balance chamber. The liquid output from the return port can be driven by the second pump body to quickly flow to chamber A or C, thereby driving the liquid in chamber D or B to flow to chamber B or D, and then driving the liquid in chamber C or A to flow to the outlet to achieve liquid suction. Thus, the functions of pushing and suction can be achieved without the need for an ultrafiltration pump, and the adjustable upper limit of the pushing and suction rate is greatly increased. Since the liquid pushed to the supply port comes only from chamber B or D, and the liquid in chamber B or D comes only from the inlet, there is no risk of waste liquid backflow and contamination during the pushing process. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the blood purification system of the present invention; Figure 2 This is a structural diagram of the liquid-pushing mode of the present invention; Figure 3 This is a structural diagram of the liquid absorption mode of the present invention.

[0016] In the diagram: 1. Dialyzer; 11. Supply port; 12. Return port; 13. Valve F; 14. Valve G; 15. Second pump body; 16. Third pump body; 17. Valve H; 2. First balancing chamber; 21. Chamber A; 22. Chamber B; 3. Second balancing chamber; 31. Chamber C; 32. Chamber D; 4. Liquid inlet; 41. First pump body; 5. Liquid outlet; 51. Valve E; 61. Valve Ao; 62. Valve Ai; 63. Valve Bo; 64. Valve Bi; 71. Valve Co; 72. Valve Ci; 73. Valve Do; 74. Valve Di. Detailed Implementation

[0017] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0018] Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains; the terminology used in the description of this application is for the purpose of describing particular embodiments only and is not intended to limit the application; the terms "comprising" and "having," and any variations thereof, in the description, claims, and accompanying drawings of this application are intended to cover non-exclusive inclusion. The terms "first," "second," etc., in the description, claims, or accompanying drawings of this application are used to distinguish different objects, and are not used to describe a particular order, hierarchy, or importance of components.

[0019] It should be noted that, unless otherwise specified, the use of terms such as "upper," "lower," "left," "right," "center," "inner," and "outer" to indicate orientation or positional relationships in the description of specific embodiments of the present invention is based on the orientation or positional relationships shown in the accompanying drawings, or the orientation or positional relationship in which the product / device / apparatus is typically placed during use. These terms are merely for the purpose of facilitating the description of the present invention or simplifying the description in specific embodiments, enabling those skilled in the art to quickly understand the solution, and do not indicate or imply that a specific device / component / element must have a specific orientation, or be constructed and operated in a specific positional relationship. Therefore, they should not be construed as limitations on the present invention. Furthermore, the use of terms such as "horizontal," "vertical," and "suspended" does not imply that the corresponding device / component / element must be absolutely horizontal, vertical, or suspended, but rather that it can be slightly tilted. For example, "horizontal" simply means that its direction is more horizontal than "vertical," not that the structure must be completely horizontal, but can be slightly tilted. Alternatively, it can be simplified to mean that the corresponding device / component / element, positioned in a specific orientation such as "horizontal," "vertical," or "suspended," can have an error / deviation of ±10% relative to that orientation, more preferably within ±8%, more preferably within ±6%, more preferably within ±5%, and more preferably within ±4%. As long as the corresponding device / component / element is within the error / deviation range, it can still fulfill its function in the present invention.

[0020] In this application, the reference to "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a mutually exclusive, independent, or alternative embodiment. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described in this application can be combined with other embodiments.

[0021] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "attachment" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0022] In this application, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. Additionally, in this application, the character " / " generally indicates that the preceding and following related objects have an "or" relationship.

[0023] In this application, "multiple" refers to two or more (including two), similarly, "multiple sets" refers to two or more (including two sets), and "multiple pieces" refers to two or more (including two pieces).

[0024] like Figures 1 to 3 As shown, a preferred embodiment of the present invention provides a blood purification system, which includes a first balancing chamber 2, a second balancing chamber 3, an inlet 4, an outlet 5, a supply port 11, and a return port 12. The first balancing chamber 2 includes chamber A 21 and chamber B 22, and the second balancing chamber 3 includes chamber C 31 and chamber D 32. The inlet 4 and the supply port 11 are both connected to chamber B 22 and chamber D 32, and the outlet 5 and the return port 12 are both connected to chamber A 21 and chamber C 31. Chamber A 21 is connected to... A valve Ai62 is installed between the return port 12, a valve Ao61 is installed between chamber A 21 and the outlet 5, a valve Bi64 is installed between chamber B 22 and the inlet 4, a valve Bo63 is installed between chamber B 22 and the supply port 11, a valve Ci72 is installed between chamber C 31 and the return port 12, a valve Co71 is installed between chamber C 31 and the outlet 5, a valve Di74 is installed between chamber D 32 and the inlet 4, and a valve Do73 is installed between chamber D 32 and the supply port 11. A first pump body 41 is provided between the liquid inlet 4 and valves Bi64 and Di74; a valve E51 is provided between the liquid outlet 5 and valves Ao61 and Co71; a valve F13 is provided between the liquid supply port 11 and valves Bo63 and Do73; and a valve G14 and a second pump body 15 are provided sequentially between the liquid return port 12 and valves Ai62 and Ci72.

[0025] Specifically, in traditional solutions, liquid aspiration or dispensing often requires an ultrafiltration pump to provide power to drive the liquid movement and to measure the liquid volume. However, to accurately measure the transferred liquid volume, ultrafiltration pumps typically use short-stroke plunger pumps, with each plunger stroke capable of transferring less than 1 ml of liquid. This results in a low maximum flow rate for the ultrafiltration pump, leading to low efficiency in the aspiration and dispensing processes using ultrafiltration pumps in traditional solutions, failing to meet current requirements. In this embodiment, a first pump body 41 is additionally installed at the inlet 4, and a valve E51 is installed at the outlet 5. A second pump body 15 is also installed between valve G14, valve Ai62, and valve Ci72. Both the first pump body 41 and the second pump body 15 are gear pumps, with an adjustable flow rate limit far exceeding that of the plunger pump used in ultrafiltration pumps. This allows them to accommodate higher flow rate requirements, satisfying the need for faster liquid aspiration and dispensing.

[0026] The first pump body 41 is used for the liquid pushing process. The first pump body 41 introduces liquid into chamber B 22 or chamber D 32, thereby squeezing the liquid in chamber A 21 or chamber C 31 and pushing the liquid into chamber C 31 or chamber A 21. Finally, the liquid in chamber D 32 or chamber B 22 is discharged to the supply port 11, thus completing the liquid pushing process. The supply port 11 is typically used to connect to the inlet interface of the dialyzer 1 and can be used for automatic pre-fluidization of the extracorporeal tubing before treatment or automatic blood return to the patient after treatment. During this process, valve E51 is in the closed state to prevent the liquid in chamber A 21 from flowing to chamber C 31 instead of being discharged to the outlet port 5, or the liquid in chamber C 31 from flowing to chamber A 21 instead of being discharged to the outlet port 5. Furthermore, in the actual liquid pushing process, continuous liquid pushing can be achieved by adjusting the communication state between the first balance chamber 2 and the second balance chamber 3, and alternately switching the communication state between the first pump body 41 and chambers B 22 and D 32.

[0027] The second pump body 15 is used for the fluid aspiration process. The second pump body 15 is connected to the return port 12 via an open valve G14. The return port 12 is typically connected to the outlet port of the dialyzer 1. The second pump body 15 draws the fluid from the dialyzer 1 into chamber C 31 or chamber A 21 through the return port 12, thereby squeezing the fluid in chamber D 32 or chamber B 22, causing the fluid in chamber D 32 or chamber B 22 to flow into chamber B 22 or chamber D 32. It also squeezes the fluid in chamber A 21 or chamber C 31, causing the fluid in chamber A 21 or chamber C 31 to be discharged to the outlet port 5, thus completing the fluid aspiration. This can be applied to automatic blood evacuation before treatment. It should also be noted that during the actual fluid aspiration process, continuous fluid aspiration can be achieved by adjusting the connection state between the first balance chamber 2 and the second balance chamber 3, and alternately switching the connection state between the second pump body 15 and chamber C 31 and chamber A 21.

[0028] Furthermore, chamber A 21 and chamber B 22 are each connected to two valves. Chamber A 21 is connected to valve E51 at outlet 5 via valve Ao61. Chamber A 21 is also connected to the second pump body 15 via valve Ai62, and finally connected to valve G14. Chamber B 22 is connected to valve F13 at supply port 11 via valve Bo63. Chamber B 22 is also connected to the first pump body 41 at inlet 4 via valve Bi64.

[0029] Chamber C 31 and Chamber D 32 are connected to two valves respectively. Chamber C 31 is connected to valve E51 at outlet 5 through valve Co71. Chamber C 31 is also connected to the second pump body 15 through valve Ci72, and finally connected to valve G14. Chamber D 32 is connected to valve F13 at supply port 11 through valve Do73. Chamber D 32 is also connected to the first pump body 41 at inlet 4 through valve Di74.

[0030] It is understandable that the liquid output from the first pump body 41 can flow to valves Bi64 and Di74 respectively, while the liquid output from valve G14, after passing through the second pump body 15, can be pumped to valves Ai62 and Ci72 respectively; similarly, valve E51 is connected to valves Ao61 and Co71 respectively, and valve F13 at the liquid supply port 11 is connected to valves Bo63 and Do73 respectively. By switching the opening and closing states of each valve, the conduction state between the first balance chamber 2, the second balance chamber 3, the first pump body 41, the second pump body 15, and the liquid outlet 5 and the liquid supply port 11 can be adjusted.

[0031] In some embodiments, a second bypass and a third pump body 16 are also included, with valve G14 connected to the third pump body 16 and the third pump body 16 connected to the first bypass. One end of the second bypass is connected to valve F13, valve Bo63, and valve Do73, and the other end of the second bypass is connected to valve G14 and the third pump body 16. The second bypass is equipped with valve H17.

[0032] Specifically, the third pump body 16 is the ultrafiltration pump. During the liquid aspiration process, in addition to the second pump body 15 alone guiding the liquid in the dialyzer 1 to chamber A 21 or chamber C 31 through valve G14 and finally discharging the liquid to outlet 5, the ultrafiltration pump can also be used in combination with the balance chamber. That is, in addition to discharging the liquid to outlet 5 through the balance chamber, the ultrafiltration pump can also discharge the liquid output from return port 12 through the first bypass. During the liquid aspiration process, the liquid discharged from the first bypass can also merge with the liquid discharged from outlet 5 for unified processing. In the liquid aspiration method of this embodiment, the second pump body 15 and the third pump body 16 can work simultaneously, sequentially, or alternately.

[0033] Furthermore, during normal treatment, if there is a problem with the fluid supplied from the balance chamber to the fluid inlet 11, the problematic fluid will no longer pass through valve F13, but will instead flow through valve H17 via the second bypass and eventually through the third pump body 16, and be discharged through the first bypass. During the fluid pushing process, if there is a problem with the fluid, it will also flow through the second bypass and the first bypass in the same way, thereby improving the safety and reliability of the entire dialysis device.

[0034] The present invention also provides a method for dispensing liquid, such as... Figure 2 As shown, using the blood purification system described above includes the following steps: S1. Close valves E51 and G14, open valve F13, and start the first pump body 41; S2, connect the first pump body 41 to chamber B 22, connect chamber A 21 to chamber C 31, and connect chamber D 32 to valve F13; S3, connects the first pump body 41 to chamber D 32, connects chamber C 31 to chamber A 21, and connects chamber B 22 to valve F13; S4. Repeatedly switch between steps S2 and S3 until the target volume of the liquid is reached.

[0035] Further, in step S2, valves Bi64, Ao61, Co71 and Do73 are opened in sequence, while valves Ai62, Bo63, Ci72 and Di74 are closed simultaneously.

[0036] Furthermore, in step S3, valves Di74, Co71, Ao61, and Bo63 are opened in sequence, while valves Ai62, Bi64, Ci72, and Do73 are closed simultaneously.

[0037] Specifically, the fluid injection method of this invention can achieve automatic pre-flushing before treatment and automatic blood return after treatment, eliminating the need for manual pre-flushing or manual blood return by the operator and the need for preparing and using saline solution. During the fluid injection process, the first pump 41 is activated, pumping liquid into chamber B 22 through valve Bi64, filling chamber B 22 with liquid and thus squeezing out the liquid in chamber A 21. Since valve Ai62 is closed, the liquid in chamber A 21 can only be discharged through the open valve Ao61. Furthermore, since valve E51 is closed, after passing through valve Ao61, the liquid can only flow to the open valve Co71 and enter chamber C 31 through valve Co71. Since valve Ci72 is closed, the liquid accumulates in chamber C 31. The liquid in chamber D 32 is squeezed and expelled. Since valves Di 74 and Bo 63 are closed, the liquid in chamber D 32 can only be pushed to the supply port 11 through the open valve F 13, thus completing one round of liquid pushing. After this pushing operation, chambers B 22 and C 31 are full, while the liquid in chambers A 21 and D 32 is discharged and they are depleted. At this point, according to step S3, the opening and closing states of each valve are switched, and the first pump body 41 fills the chamber with liquid through the open valve Di 74. Liquid enters chamber D 32. Because valve Do73 is closed, chamber D 32 gradually fills and compresses chamber C 31. Because valve Ci72 is closed, the liquid in chamber C 31 can only be introduced into chamber A 21 sequentially through valves Co71 and Ao61. Because valve Ai62 is closed, chamber A 21 gradually fills and compresses chamber B 22, thus pushing the liquid out of chamber B 22. Because valve Bi64 is closed, the liquid in chamber B 22 can only be pushed to the supply port 11 sequentially through valves Bo63 and F13. This completes the second round of liquid pushing, at which point the states of chambers A 21, B 22, C 31, and D 32 are completely opposite to their states after the first round of liquid pushing. This process is then repeated cyclically in steps S2 and S3, ensuring a stable and continuous liquid pushing operation. Thanks to the first pump body 41, this embodiment does not utilize the plunger pump structure found in ultrafiltration pumps; instead, it employs a gear pump in the first pump body 41, significantly increasing the adjustable flow rate and thus greatly improving the efficiency of liquid pushing. It should also be noted that steps S2 and S3 are not sequential and can be performed alternately.

[0038] It should also be noted that the liquid inlet 4 is filled with pure fresh liquid. In this embodiment, the fresh liquid is pumped into chamber B 22 or chamber D 32 through the first pump body 41. During the alternating liquid pushing process, only the fresh liquid in chamber B 22 and chamber D 32 can be pushed to the liquid supply port 11 and enter the dialyzer 1 through the liquid inlet interface connected to the liquid supply port 11. During this process, the fresh liquid is completely isolated from the waste liquid in chamber A 21 and chamber C 31, and the problem of waste liquid backflow and pollution caused by the reverse liquid pushing of the ultrafiltration pump in the traditional solution will not occur.

[0039] In traditional solutions, although ultrafiltration pumps have a relatively small flow rate limit, they can accurately measure the amount of liquid. However, in this embodiment, a first pump body 41 is used to drive the liquid, so a new method is needed to measure the amount of liquid being pushed.

[0040] In some embodiments, the target volume of liquid pusher = volume of balance chamber V * number of liquid pusher chambers = liquid volume per unit jog of valve * total number of jogs of liquid pusher from valve body; The number of chambers includes a whole chamber part and a fractional part. The balance chamber volume V * fractional part of the number of chambers = number of valve body jogs under the fractional part of the number of chambers * volume of liquid per valve jog. The volume of liquid per unit jog of the valve = the volume of the balance chamber V / the total number of jogs when the valve body passes through a volume V of liquid; Jogging speed = Unit jogging liquid volume / Jogging interval duration.

[0041] Specifically, in this embodiment, one round of liquid pushing refers to chamber B 22 being completely filled with the fresh liquid provided by the first pump body 41, and chamber A 21 being squeezed. Then, the liquid in chamber A 21 is filled into chamber C 31 and squeezed into chamber D 32, or chamber D 32 is completely filled with the provided fresh liquid and chamber C 31 is squeezed. Then, the liquid in chamber C 31 is filled into chamber A 21 and squeezed into chamber B 22. A complete round of liquid pushing requires filling a single equilibrium chamber volume V of liquid. Therefore, the actual number of chambers varies depending on the target volume of liquid pushing. In addition to the portion of liquid pushing into the entire chamber, there may be a small amount of liquid that is insufficient to fill the entire chamber. Therefore, the number of chambers may have a decimal part. When actually measuring the liquid pushing volume, the whole chamber part of the number of chambers can be obtained by switching between steps S2 and S3, while the decimal part of the number of chambers is obtained by jogging the valve body. First, the amount of liquid per unit jogging of the valve body is determined, and then the number of joggings of the valve body is determined. This determines the decimal part of the number of chambers, and finally, the liquid volume of liquid pushing is accurately measured. The amount of liquid per valve jog can be pre-calculated by measuring how many jogs are needed to fill the balance chamber, which is expressed by the formula: "Liquid amount per valve jog = Balance chamber volume V / Total number of jogs when the valve body passes through volume V of liquid". It should also be noted that in this embodiment, the pushing speed can be controlled by controlling the jog of any one of the valves in a conducting state, where "Jog speed = Liquid amount per valve jog / Jog interval duration". By controlling the jog interval duration, the overall pushing speed can be controlled.

[0042] The present invention also provides a liquid aspiration method, such as Figure 3 As shown, using the blood purification system as described above includes the following steps: S5. Open valves E51 and G14, close valve F13, and open the second pump body 15; S6, connect the second pump body 15 to chamber C 31, connect chamber D 32 to chamber B 22, and connect chamber A 21 to outlet 5; S7, connect the second pump body 15 to chamber A 21, connect chamber B 22 and chamber D 32, and connect chamber C 31 to outlet 5; S8. Repeatedly switch between steps S6 and S7 until the target volume of liquid is reached.

[0043] Further, in step S6, valves Ci72, Do73, Bo63 and Ao61 are opened in sequence, while valves Ai62, Bi64, Co71 and Di74 are closed simultaneously.

[0044] Further, in step S7, valves Ai62, Bo63, Do73 and Co71 are opened in sequence, while valves Ci72, Di74, Bi64 and Ao61 are closed simultaneously.

[0045] Specifically, during this liquid suction stage, valve G14 opens, and the second pump body 15 starts, sending the liquid at the return port 12 to chamber C 31 via valve Ci72. Since valve Co71 is closed, chamber C 31 is filled and chamber D 32 is compressed. Because valve Di74 is closed, the liquid in chamber D 32 can only be discharged through valve Do73 and input into chamber B 22 via the open valve Bo63. Because valve Bi64 is closed, chamber B 22 is filled and chamber A 21 is compressed. Because valve Ai62 is closed, the liquid in chamber A 21 can only be discharged through valve Ao61, and finally discharged from outlet 5 through the open valve E51, completing the first round of liquid suction. After the first round of liquid suction, chamber C 31 and chamber B 22 are in a full state, while chamber D 32 and chamber A 21 are in a deflated state after the liquid is discharged. At this time, according to step S7, the opening and closing states of each valve are switched, and the second pump body 15 sends the liquid at the return port 12 through valve Ai73... Liquid is drawn into chamber A 21 by pump 62. At this time, valve Ao61 is closed, and chamber A 21 gradually fills and squeezes chamber B 22. Since valve Bi64 is closed, the liquid in chamber B 22 can only be pushed into chamber D 32 through valves Bo63 and Do73. Since valve Di74 is closed, chamber D 32 gradually fills and squeezes chamber C 31. Since valve Ci72 is closed, the liquid in chamber C 31 can only be discharged through valve Co71 and finally discharged through outlet 5, realizing the second round of liquid suction. At this time, the states of chambers A 21, B 22, C 31 and D 32 are completely opposite to the states after the first round of liquid suction. Then, the process is repeated in steps S6 and S7 to achieve stable and continuous liquid suction. With the setting of the second pump body 15, this embodiment does not rely on the plunger pump structure of the ultrafiltration pump, but uses the second pump body 15 of the gear pump, which greatly increases the upper limit of the adjustable flow rate, thereby greatly improving the efficiency of liquid suction. It should also be noted that steps S6 and S7 are not sequential and can be performed alternately. The fluid aspiration mode can be used to achieve automatic blood evacuation before dialysis treatment, eliminating the need for manual blood evacuation and the use of waste bags to collect fluid from the extracorporeal circulation tubing.

[0046] In some embodiments, the target volume of liquid aspiration = the volume of the balance chamber V * the number of aspiration chambers = the liquid volume per unit jog of the valve * the total number of jogs of the valve body; The number of chambers includes a whole chamber part and a fractional part. The balance chamber volume V * fractional part of the number of chambers = number of valve body jogs under the fractional part of the number of chambers * volume of liquid per valve jog. The volume of liquid per unit jog of the valve = the volume of the balance chamber V / the total number of jogs when the valve body passes through a volume V of liquid; Jogging speed = Unit jogging liquid volume / Jogging interval duration.

[0047] Specifically, in this embodiment, one round of liquid aspiration refers to chamber A 21 being completely filled with the liquid provided by the second pump body 15 and chamber B 22 being squeezed, followed by the liquid in chamber B 22 being filled into chamber D 32 and squeezing chamber C 31, or chamber C 31 being completely filled with the liquid provided by the second pump body 15 and chamber D 32 being squeezed, followed by the liquid in chamber D 32 being filled into chamber B 22 and squeezing chamber A 21. A complete round of liquid aspiration requires filling a single equilibrium chamber volume V of liquid. Depending on the target volume of liquid aspiration, the actual number of chambers will vary. Besides the portion aspirated into the entire chamber, there may be a small amount of liquid insufficient for the entire chamber, thus the number of chambers may have a decimal part. When actually measuring the aspirated volume, the entire chamber number can be obtained by switching between steps S6 and S7, while the decimal part is obtained by jogging the valve body. First, the amount of liquid per jog of the valve body is determined, then the number of jogs of the valve body is determined, thus determining the decimal part of the number of chambers and ultimately accurately measuring the aspirated liquid volume. The amount of liquid per valve jog can be pre-calculated by measuring how many jogs are needed to fill the balance chamber, which is expressed by the formula: "Liquid volume per valve jog = Balance chamber volume V / Total number of jogs when the valve body passes through volume V of liquid". It should also be noted that in this embodiment, the suction speed can be controlled by controlling the jog of any one of the valve's conducting states, where "Jog speed = Liquid volume per valve jog / Jog interval duration". By controlling the jog interval duration, the overall suction speed can be controlled.

[0048] Furthermore, if liquid aspiration is performed jointly by the second pump body 15 and the third pump body 16, this joint aspiration can be performed simultaneously by the second pump body 15 and the third pump body 16, or sequentially or alternately by the second pump body 15 and the third pump body 16. Then, the target liquid aspiration volume = equilibrium chamber volume V * number of aspiration chambers + liquid aspiration volume of the third pump body 16. With the target liquid aspiration volume set, the liquid aspiration volume of the third pump body 16, being an ultrafiltration pump, can be easily calculated. The equilibrium chamber volume V is a fixed value, and the number of aspiration chambers can then be obtained as described above.

[0049] In summary, this embodiment of the invention provides a blood purification system. A valve E51 is additionally installed at the outlet 5, and a first pump body 41 is installed at the inlet 4. During the liquid pushing phase, the first pump body 41 located at the inlet 4 provides power and controls the opening and closing of relevant valves, changing the working mode of the balance chamber. This allows for the rapid propulsion of liquid from the inlet 4 to chamber B 22 or chamber D 32, thereby driving liquid in chamber A 21 or chamber C 31 to flow to chamber C 31 or chamber A 21, and further driving liquid in chamber D 32 or chamber B 22 to flow to the supply chamber. In the liquid feeding stage, the liquid is fed to the outlet 11 to achieve liquid pushing. During the liquid suction stage, the on / off state of the relevant valves is controlled to change the working mode of the balance chamber. Liquid output from the return port 12 can be driven by the second pump body 15 to quickly flow to chamber A 21 or chamber C 31, thereby driving liquid in chamber D 32 or chamber B 22 to flow to chamber B 22 or chamber D 32, and then driving liquid in chamber C 31 or chamber A 21 to flow to the outlet 4, thus achieving liquid suction. This allows for both liquid pushing and suction without the need for an ultrafiltration pump, and significantly increases the adjustable upper limit of the pushing and suction rates. The volume of liquid pushed and suctioned can be measured by the number of jogs of the solenoid valve. Since the liquid pushed to the supply port 11 comes only from chamber B 22 or chamber D 32, and the liquid in chamber B 22 or chamber D 32 comes only from the inlet 4, there is no risk of waste liquid backflow and contamination during liquid pushing.

[0050] The above are merely preferred embodiments of the present invention. It should be noted that those skilled in the art can make several improvements and substitutions without departing from the technical principles of the present invention, and these improvements and substitutions should also be considered within the scope of protection of the present invention.

Claims

1. A blood purification system comprising a first balance chamber, a second balance chamber, a liquid inlet, a liquid outlet, a liquid supply, and a liquid return, the first balance chamber comprising an A chamber and a B chamber, the second balance chamber comprising a C chamber and a D chamber, characterized in that, The inlet and the supply port are both connected to chamber B and chamber D, and the outlet and the return port are both connected to chamber A and chamber C. A valve Ai is provided between chamber A and the return port, and a valve Ao is provided between chamber A and the outlet. A valve Bi is provided between chamber B and the inlet, and a valve Bo is provided between chamber B and the supply port. A valve Ci is provided between chamber C and the return port, and a valve Co is provided between chamber C and the outlet. A valve Di is provided between chamber D and the inlet, and a valve Do is provided between chamber D and the supply port. A first pump body is provided between the inlet and valves Bi and Di; valve E is provided between the outlet and valves Ao and Co; valve F is provided between the supply port and valves Bo and Do; and valve G and a second pump body are provided sequentially between the return port and valves Ai and Ci.

2. The blood purification system of claim 1, wherein, It also includes a second bypass and a third pump body, wherein the valve G is connected to the third pump body, and the third pump body is connected to the first bypass; One end of the second bypass is connected to valve F, valve Bo, and valve Do, and the other end of the second bypass is connected to valve G and the third pump body. The second bypass is equipped with valve H.

3. A method for injecting fluid, using the blood purification system as described in claim 1, characterized in that, Includes the following steps: S1. Close valves E and G, open valve F, and start the first pump body; S2, connect the first pump body to chamber B, connect chamber A to chamber C, and connect chamber D to valve F; S3. Connect the first pump body to chamber D, connect chamber C to chamber A, and connect chamber B to valve F; S4. Repeatedly switch between steps S2 and S3 until the target volume of the liquid is reached.

4. The method for dispensing liquid according to claim 3, characterized in that, In step S2, valves Bi, Ao, Co, and Do are opened sequentially, while valves Ai, Bo, Ci, and Di are closed simultaneously.

5. The method for pushing liquid according to claim 3, characterized in that, In step S3, valves Di, Co, Ao, and Bo are opened sequentially, while valves Ai, Bi, Ci, and Do are closed simultaneously.

6. The method for dispensing liquid according to claim 3, characterized in that, The target volume of the liquid pusher = the volume of the balance chamber V * the number of liquid pusher chambers = the liquid volume per unit jog of the valve * the total number of jogs of the valve body. Wherein, the total number of times the valve body pushes the liquid is 1 / 2 the total number of times the valve Ao or the valve Co is 1 / 2. The volume of liquid per unit jog of the valve = the volume of the balance chamber V / the total number of jogs when the valve body passes through a volume V of liquid; Jogging speed = Unit jogging liquid volume / Jogging interval duration.

7. A method for aspirating liquid, using the blood purification system as described in claim 1, characterized in that, Includes the following steps: S5. Open valves E and G, close valve F, and open the second pump body; S6. Connect the second pump body to the C chamber, connect the D chamber to the B chamber, and connect the A chamber to the liquid outlet; S7. Connect the second pump body to chamber A, connect chamber B and chamber D, and connect chamber C to the liquid outlet; S8. Repeatedly switch between steps S6 and S7 until the target volume of liquid is reached.

8. The liquid aspiration method according to claim 7, characterized in that, In step S6, valve Ci, valve Do, valve Bo and valve Ao are opened in sequence, and valve Ai, valve Bi, valve Co and valve Di are closed simultaneously.

9. The liquid aspiration method according to claim 7, characterized in that, In step S7, valves Ai, Bo, Do, and Co are opened sequentially, while valves Ci, Di, Bi, and Ao are closed simultaneously.

10. The liquid aspiration method according to claim 7, characterized in that, The target volume of liquid to be absorbed = volume of the balance chamber V * number of liquid absorption chambers = liquid volume per unit jog of the valve * total number of jogs of liquid absorption of the valve body; Wherein, the total number of times the valve body draws liquid is 1 / 2 the total number of times the valve Bo or the valve Do is 1 / 2; The volume of liquid per unit jog of the valve = the volume of the balance chamber V / the total number of jogs when the valve body passes through a volume V of liquid; Jogging speed = Unit jogging liquid volume / Jogging interval duration.

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