Fermentation reaction equipment for veterinary drug production raw materials

Abstract

This invention relates to the field of fermentation tank technology, and more particularly to a fermentation reaction device for veterinary drug production raw materials. The device includes a fermenter and a lid fixed to the top of the fermenter. A microbial storage tank is mounted on the outer wall of the lid. A control unit is mounted on the outer wall of the fermenter. An inoculation port communicating with the fermenter is opened on the inner bottom wall of the microbial storage tank. In this invention, when the temperature inside the tank drops to the inoculation temperature, the inoculation tube moves upward, causing the sliding column on the stopper to disengage from the drive shaft. Under the action of a spring, the stopper seals the discharge port. When the inoculation tube, through the microbial collection port, enters the microbial storage tank, the microbial suspension in the storage tank flows naturally into the inoculation tube under gravity. Compared to the existing pump-assisted inoculation method, this invention provides a gentler inoculation process, which is beneficial for improving the integrity and survival rate of the inoculated bacteria. The microbial suspension fills the inner cavity of the inoculation tube. Repeating the above process allows for multiple quantitative inoculations.

Description

Technical Field

[0001] This invention relates to the field of fermentation tank technology, and in particular to a fermentation reaction device for veterinary drug production raw materials. Background Technology

[0002] In the field of veterinary drug production, fermentation reaction is the core link in raw material preparation. Its efficiency and quality directly determine the efficacy, purity and safety of the finished veterinary drug. Aseptic inoculation, as the key starting step of the fermentation process, is the core prerequisite for ensuring pure culture of the fermentation system and avoiding contamination by other microorganisms. It is also the basic guarantee for improving fermentation efficiency. At present, the aseptic inoculation method of veterinary drug production raw material fermentation reaction equipment generally adopts a peristaltic pump with a one-way valve structure, relying on the pressure difference suction principle to realize the delivery and inoculation of the strain. However, when the pump is working, it delivers the inoculum by squeezing the elastic hose with rollers. The fluid impact generated during the pressure differential suction process, in conjunction with the one-way valve, will exert continuous mechanical stress on the inoculum. As the core of the fermentation reaction, the activity and integrity of the inoculum directly affect the fermentation process. This kind of mechanical stress can easily cause cell wall damage, reduced activity, and even inactivation of some inoculum. This will not only cause slow fermentation start-up and reduced cell proliferation efficiency, but also affect the raw material conversion rate and the amount of target product synthesis, resulting in a longer fermentation cycle, increased raw material loss, and increased veterinary drug production costs. Summary of the Invention

[0003] The purpose of this invention is to overcome the shortcomings of existing technologies and propose a fermentation reaction device for veterinary drug production raw materials. This invention uses an inoculation tube. When the temperature inside the tank drops to the inoculation temperature, the inoculation tube moves upward, causing the sliding column on the stopper to disengage from the drive shaft. Under the action of a spring, the stopper seals the discharge port. When the inoculation tube leads the bacterial collection port into the storage tank, the bacterial suspension in the storage tank flows naturally into the inoculation tube under gravity. Compared with the existing technology's pump-assisted inoculation method, this invention's inoculation process is gentler, which helps improve the integrity and survival rate of the inoculated bacteria. The bacterial suspension fills the inner cavity of the inoculation tube. Repeating the above process can achieve multiple quantitative inoculations.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: a fermentation reaction device for veterinary drug production raw materials, comprising a fermenter and a lid fixed to the top of the fermenter, a storage tank being provided on the outer wall of the top of the lid, a control unit being provided on the outer wall of the fermenter, an inoculation port communicating with the fermenter being provided on the bottom inner wall of the storage tank, an inoculation tube being slidably connected to the inoculation port, an expansion tube communicating with the inoculation tube being provided on the side wall of the inoculation tube, a collection port being provided at the top of the inoculation tube, a discharge port being provided at the bottom of the inoculation tube, a sealing component being provided in the discharge port, a first electric push rod being fixedly installed on the outer wall of the storage tank to drive the inoculation tube to slide up and down, and a temperature measuring component being provided inside the fermenter. When the temperature inside the fermenter drops to a suitable inoculation temperature, the temperature measuring component triggers the extension and retraction of the first electric push rod, which drives the inoculation tube into the storage tank and collects a quantitative amount of bacterial suspension. A motor is fixedly installed on the bottom outer wall of the fermenter. The output end of the motor is fixed with a drive shaft extending to the bottom of the inoculation tube. Whenever the inoculation tube moves down and resets, the drive shaft triggers the sealing component and opens the discharge port. A stirring component is installed on the drive shaft and rotates with the drive shaft. The inoculum suspension discharged from the discharge port diffuses into the fermenter through the stirring component. An adjustment component is installed inside the fermenter. When the raw material liquid level in the fermenter rises, the adjustment component drives the stirring component to move upward along the drive shaft and increases the internal volume of the expansion tube.

[0005] Preferably, the temperature measuring component includes a spacer fixed to the inner wall of the tank lid, a temperature sensor fixed to the outer wall of the tank lid, a probe of the temperature sensor inserted into the spacer, a heat-conducting rod slidably connected to the outer wall of the spacer, and the end of the heat-conducting rod away from the spacer extending to the bottom of the fermenter. The first electric push rod and the control unit are electrically connected via the temperature sensor signal.

[0006] Preferably, the output end of the first electric push rod is fixed with a first support rod extending into the fermenter, and the end of the first support rod away from the first electric push rod is fixed to the outer wall of the expansion tube.

[0007] Preferably, the sealing assembly includes a plug that is slidably inserted into the feed port, a spring is provided between the outer wall of the plug and the inner wall of the inoculation tube, and a sliding post extending to the outside of the inoculation tube is provided on the outer wall of the plug.

[0008] Preferably, the stirring assembly includes a sleeve that is slidably fitted on the outer wall of the drive shaft, a flow guide fixed on the outer wall of the sleeve and located below the inoculation tube, a stirring paddle fixed on the bottom outer wall of the sleeve, a limiting groove extending axially on the outer wall of the drive shaft, and a limiting block that engages with the limiting groove on the inner wall of the sleeve.

[0009] Preferably, the adjustment assembly includes a mounting bracket rotatably connected to the top of the sleeve, a second support rod extending to the outside of the tank cover is fixed on the outer wall of the mounting bracket, a second electric push rod is fixed on the outer wall of the storage tank, the output end of the second electric push rod is fixed to the end of the second support rod, an ultrasonic level sensor is fixedly installed on the outer wall of the tank cover, and the second electric push rod is electrically connected to the control unit via the ultrasonic level sensor signal.

[0010] Preferably, the inner wall of the fermenter is provided with a slide rail, a slide seat is slidably connected in the slide rail, a connecting rod is rotatably connected to the outer wall of the slide seat, and the end of the connecting rod away from the slide seat is rotatably connected to the outer wall of the mounting frame.

[0011] Preferably, the slide block is slidably sleeved on the outer wall of the heat-conducting rod, a piston is slidably connected inside the expansion tube, and a slide rod extending to the outside of the inoculation tube is provided on the outer wall of the piston, the slide rod being slidably sleeved on the outer wall of the heat-conducting rod.

[0012] Compared with the prior art, the beneficial effects of the present invention are: 1. In this invention, when the temperature inside the tank drops to the inoculation temperature, the inoculation tube moves upward and causes the sliding column on the stopper to disengage from the drive shaft. Under the action of the spring, the stopper blocks the discharge port. When the inoculation tube drives the bacterial collection port into the storage tank, the bacterial suspension in the storage tank flows naturally into the inoculation tube under the action of gravity. Compared with the existing technology of inoculation by pump suction, the inoculation process of this invention is gentler, which is conducive to improving the integrity and survival rate of the inoculated bacteria. The bacterial suspension fills the inner cavity of the inoculation tube. Repeating the above process can achieve the effect of multiple quantitative inoculations.

[0013] 2. This invention, through the design of a spacer and a heat-conducting rod, allows the temperature sensor probe to be suspended inside the spacer, preventing temperature sensor distortion caused by high temperatures inside the fermenter. The heat-conducting rod extends to the bottom of the fermenter, transferring the temperature of the inner layer of raw materials to the spacer, making the temperature sensor reading close to the actual temperature of the inner layer of raw materials. Since the inner layer of raw materials cools down more slowly, this structure avoids inoculation when the inner layer temperature is too high, further ensuring the survival rate of the strain.

[0014] 3. This invention, through its adjustable components, allows the ultrasonic level gauge to monitor the liquid level of the raw materials in the fermenter after they are added. When the level exceeds a threshold, the sleeve moves the stirring paddle upwards, thereby adjusting the relative position of the stirring paddle and the raw material surface. This prevents the upper layer of raw materials from being insufficiently stirred. Simultaneously, the sleeve moves the mounting frame upwards, and the mounting frame pulls the slide towards the inoculation tube via a connecting rod. The slide moves the heat-conducting rod towards the center of the fermenter, and the slide pushes the piston towards the outer end of the expansion tube via the heat-conducting rod, thereby increasing the volume inside the expansion tube. This, in turn, increases the overall internal volume of the inoculation tube, achieving the effect of increasing the inoculation amount while increasing the amount of raw materials.

[0015] 4. The present invention, through the setting of the stirring component, enables the motor to be started during inoculation. The motor drives the sleeve to rotate through the transmission shaft. The sleeve drives the guide frame and stirring paddle to rotate. The inoculum suspension discharged from the inoculation tube diffuses along the rotating guide frame to the periphery of the fermenter, which helps to improve the uniformity of inoculation and avoids the inoculum suspension settling in the center of the fermenter. Attached Figure Description

[0016] Figure 1 This is a three-dimensional schematic diagram of the overall structure proposed in this invention; Figure 2 This is a three-dimensional sectional view of the overall structure proposed in this invention; Figure 3 This is a three-dimensional schematic diagram of the inoculation tube proposed in this invention; Figure 4 This is a three-dimensional cross-sectional view of the inoculation tube proposed in this invention; Figure 5 This is a three-dimensional schematic diagram of the mounting bracket proposed in this invention; Figure 6 This is a three-dimensional cross-sectional view of the stirring assembly proposed in this invention; Figure 7 This is a three-dimensional cross-sectional view of the inoculation tube in operation as proposed in this invention.

[0017] Legend: 1. Fermentation tank; 11. Tank lid; 12. Storage tank; 121. Inoculation port; 13. Control unit; 2. Inoculation tube; 21. Inoculum collection port; 22. Expansion tube; 221. Piston; 222. Sliding rod; 23. Discharge port; 231. Plug; 232. Spring; 233. Sliding column; 24. First electric push rod; 241. First support rod; 3. Motor; 31. Drive shaft; 32. Sleeve; 321. Flow guide; 322. Stirring paddle; 4. Spacer; 41. Temperature sensor; 42. Heat conduction rod; 5. Mounting bracket; 51. Connecting rod; 52. Slide seat; 53. Second electric push rod; 531. Second support rod; 54. Slide rail; 55. Ultrasonic level gauge. Detailed Implementation

[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0019] See Figures 1 to 7 As shown, a fermentation reaction device for veterinary drug production raw materials includes a fermenter 1 and a lid 11 fixed to the top of the fermenter 1. A storage tank 12 is provided on the outer wall of the top of the lid 11. A control unit 13 is provided on the outer wall of the fermenter 1. An inoculation port 121 communicating with the fermenter 1 is opened on the inner wall of the bottom of the storage tank 12. An inoculation tube 2 is slidably connected in the inoculation port 121. An expansion tube 22 communicating with the inoculation tube 2 is provided on the side wall of the inoculation tube 2. A collection port 21 is opened at the top of the inoculation tube 2. A discharge port 23 is provided at the bottom of the inoculation tube 2. A sealing component is provided in the discharge port 23. A first electric push rod 24 for driving the inoculation tube 2 to slide up and down is fixedly installed on the outer wall of the storage tank 12. A temperature measuring component is provided in the fermenter 1. When the temperature in the fermenter 1 drops to a suitable inoculation temperature, the temperature measuring component triggers the extension and retraction of the first electric push rod 24. The first electric push rod 24 drives the inoculation tube 2 into the storage tank 12 and collects a quantitative amount of bacterial suspension. A motor 3 is fixedly installed on the bottom outer wall of the fermenter 1. The output end of the motor 3 is fixed with a drive shaft 31 extending to the bottom of the inoculation tube 2. Whenever the inoculation tube 2 moves down and resets, the drive shaft 31 triggers the sealing component and opens the discharge port 23. A stirring component is provided on the drive shaft 31 and rotates with the drive shaft 31. The inoculum suspension discharged from the discharge port 23 diffuses into the fermenter 1 through the stirring component. An adjustment component is provided inside the fermenter 1. When the raw material liquid level in the fermenter 1 rises, the adjustment component drives the stirring component to move up along the drive shaft 31 and increases the internal volume of the expansion tube 22. The temperature measuring assembly includes a spacer 4 fixed on the inner wall of the tank lid 11, a temperature sensor 41 fixed on the outer wall of the tank lid 11, a probe of the temperature sensor 41 inserted into the spacer 4, a heat-conducting rod 42 slidably connected on the outer wall of the spacer 4, and one end of the heat-conducting rod 42 away from the spacer 4 extending to the bottom of the fermenter 1. The first electric push rod 24 and the control unit 13 are electrically connected by the temperature sensor 41. The output end of the first electric push rod 24 is fixed with a first support rod 241 extending into the fermenter 1. One end of the first support rod 241 away from the first electric push rod 24 is fixed on the outer wall of the expansion tube 22. The sealing assembly includes a plug 231 that is slidably inserted into the feed port 23. A spring 232 is provided between the outer wall of the plug 231 and the inner wall of the inoculation tube 2. A sliding post 233 extending to the outside of the inoculation tube 2 is provided on the outer wall of the plug 231.

[0020] It should be noted that before the raw materials are fed in, the first electric push rod 24 is extended. The first electric push rod 24 drives the inoculation tube 2 to move upward through the first support rod 241. The inoculation tube 2 drives the inoculation port 21 to fit against the inner wall of the inoculation port 121, closing the inoculation port 21. At this time, the inoculum suspension in the storage tank 12 will not enter the inoculation tube 2. At the same time, the inoculation tube 2 drives the sliding column 233 in the discharge port 23 to abut against and squeeze the drive shaft 31. The drive shaft 31 pushes the plug 231 upward through the sliding column 233, thereby opening the discharge port 23.

[0021] Raw materials are fed into the fermenter 1 through the feed inlet. The fermenter 1's own high-temperature system sterilizes the raw materials. At the same time, since the discharge port 23 in the inoculation tube 2 is open, the fermenter 1 can simultaneously sterilize the inner cavity of the inoculation tube 2 at high temperature, creating sterile conditions for inoculation and avoiding contamination by external bacteria.

[0022] Temperature sensor 41 detects the temperature of the raw materials in fermenter 1. When the temperature inside the fermenter drops to the inoculation temperature, control unit 13 controls the first electric push rod 24 to retract, the inoculation tube 2 moves upward and causes the sliding column 233 on the plug 231 to disengage from the drive shaft 31. Under the action of spring 232, the plug 231 seals the discharge port 23. When the inoculation tube 2 drives the inoculum outlet 21 into the storage tank 12, the inoculum suspension in the storage tank 12 flows naturally into the inoculation tube 2 under the action of gravity. Compared with the existing technology, this method... The pump-assisted inoculation method of this invention makes the inoculation process gentler, which helps to improve the integrity and survival rate of the inoculated bacteria. The bacterial suspension fills the inner cavity of the inoculation tube 2. Repeating the above process can achieve the effect of multiple quantitative inoculations. Then, the first electric push rod 24 is controlled to extend and reset, the inoculation tube 2 moves down and resets, and triggers the sealing component to open the discharge port 23, so that the bacterial suspension falls into the fermenter 1. Since the fermenter 1 and the storage tank 12 are separated by the inoculation tube 2, the two are not directly connected, thus avoiding backflow during inoculation.

[0023] In addition, the probe of the temperature sensor 41 is suspended inside the partition sleeve 4 to prevent the temperature sensor 41 from being distorted due to the high temperature inside the fermenter 1. The heat-conducting rod 42 extends to the bottom of the fermenter 1 and can transfer the temperature of the inner layer of raw materials at the bottom of the tank to the partition sleeve 4, so that the detected value of the temperature sensor 41 is close to the actual temperature of the inner layer of raw materials. Since the inner layer of raw materials cools down slowly, this structure avoids the situation of inoculation when the inner layer temperature is too high, further ensuring the survival rate of the strain.

[0024] The stirring assembly includes a sleeve 32 that is slidably sleeved on the outer wall of the drive shaft 31. A guide frame 321 located below the inoculation tube 2 is fixed on the outer wall of the sleeve 32. A stirring paddle 322 is fixed on the outer wall of the bottom end of the sleeve 32. A limiting groove is extended axially on the outer wall of the drive shaft 31. A limiting block that mates with the limiting groove is provided on the inner wall of the sleeve 32. The adjustment assembly includes a mounting bracket 5 rotatably connected to the top of the sleeve 32. A second support rod 531 extending to the outside of the tank cover 11 is fixed on the outer wall of the mounting bracket 5. A second electric push rod 53 is fixed on the outer wall of the storage tank 12. The output end of the second electric push rod 53 is fixed to the end of the second support rod 531. An ultrasonic level sensor 55 is fixedly installed on the outer wall of the tank cover 11. The second electric push rod 53 and the control unit 13 are electrically connected via the ultrasonic level sensor 55. A slide rail 54 is provided on the inner wall of the fermenter 1. A slide seat 52 is slidably connected in the slide rail 54. A connecting rod 51 is rotatably connected on the outer wall of the slide seat 52. The end of the connecting rod 51 away from the slide seat 52 is rotatably connected to the outer wall of the mounting bracket 5. The slide seat 52 is slidably sleeved on the outer wall of the heat-conducting rod 42. A piston 221 is slidably connected in the expansion tube 22. A slide rod 222 extending to the outside of the inoculation tube 2 is provided on the outer wall of the piston 221. The slide rod 222 is slidably sleeved on the outer wall of the heat-conducting rod 42.

[0025] It should be noted that before the raw materials are fed in, the second electric push rod 53 is extended. The second electric push rod 53 moves down through the second support rod and the mounting bracket 5. The mounting bracket 5 drives the sleeve 32 to move down. The sleeve 32 drives the agitator 322 to be located at the bottom of the fermenter 1. Under the action of the connecting rod 51, the slide 52 is located at the end of the slide rail 54 away from the inoculation tube 2, and the piston 221 is located at the innermost end of the expansion tube 22. At this time, the internal volume of the inoculation tube 2 is at its minimum.

[0026] After the raw materials are added, the liquid level of the raw materials in the fermentation tank 1 is checked by the ultrasonic level gauge 55. When the level is higher than the threshold, it indicates that the liquid level of the raw materials in the tank is high and the amount of raw materials is large. At this time, the control unit 13 controls the second electric push rod 53 to retract. The second electric push rod 53 drives the sleeve 32 to move upward, and the sleeve 32 drives the stirring paddle 322 to move upward, thereby adjusting the relative position of the stirring paddle 322 and the raw material liquid level to avoid the situation where the upper layer of raw materials cannot be stirred. At the same time, the sleeve 32 drives the mounting frame 5 to move upward synchronously. The mounting frame 5 pulls the slide 52 closer to the inoculation tube 2 through the connecting rod 51. The slide 52 drives the heat-conducting rod 42 closer to the center of the fermentation tank 1. The slide 52 pushes the piston 221 to slide through the heat-conducting rod 42. The piston 221 slides to the outer end of the expansion tube 22, thereby increasing the volume inside the expansion tube 22. Since the expansion tube 22 is connected to the inoculation tube 2, the overall internal volume of the inoculation tube 2 is increased, thereby achieving the effect of increasing the inoculation amount while increasing the amount of raw materials.

[0027] Furthermore, the slide block 52 drives the heat-conducting rod 42 closer to the center of the fermenter 1, so that the heat-conducting rod 42 can transfer the temperature of the raw material near the center of the tank to the partition sleeve 4, ensuring the reliability of the temperature measuring component and avoiding the situation where the temperature of the inner raw material is too high, resulting in a decrease in the survival rate of the strain.

[0028] During inoculation, motor 3 is started. Motor 3 drives sleeve 32 to rotate through transmission shaft 31. Sleeve 32 drives guide frame 321 and stirring paddle 322 to rotate. The inoculum suspension discharged from inoculation tube 2 diffuses along the rotating guide frame 321 to the periphery of fermenter 1, which helps to improve the uniformity of inoculation and prevents the inoculum suspension from settling in the center of fermenter 1. At the same time, stirring paddle 322 promotes the mixing of raw materials and inoculum suspension, which helps to improve fermentation efficiency.

[0029] Working principle: Before the raw materials are put in, such as Figure 2 As shown, the first electric push rod 24 is extended, and the first electric push rod 24 drives the inoculation tube 2 to move upward through the first support rod 241. The inoculation tube 2 drives the inoculation port 21 to fit against the inner wall of the inoculation port 121, closing the inoculation port 21. At this time, the inoculum suspension in the storage tank 12 will not enter the inoculation tube 2. At the same time, the inoculation tube 2 drives the sliding column 233 in the discharge port 23 to abut and squeeze against the drive shaft 31. The drive shaft 31 pushes the plug 231 upward through the sliding column 233, thereby opening the discharge port 23. The second electric push rod 53 is extended, and the second electric push rod 53 drives the mounting bracket 5 downward through the second support rod. The mounting bracket 5 drives the sleeve 32 downward. The sleeve 32 drives the stirring paddle 322 to be located at the bottom of the fermenter 1. Under the action of the connecting rod 51, the sliding seat 52 is located at the end of the slide rail 54 away from the inoculation tube 2, and the piston 221 is located at the innermost end of the expansion tube 22. At this time, the internal volume of the inoculation tube 2 is in the minimum state. The raw materials are fed into fermenter 1 through the feed inlet, and sterilized by the high-temperature system built into fermenter 1. Simultaneously, ... Figure 4 As shown, since the discharge port 23 inside the inoculation tube 2 is in the open state, the fermenter 1 can simultaneously sterilize the inner cavity of the inoculation tube 2 at high temperature, creating sterile conditions for inoculation and avoiding contamination by external bacteria. like Figure 2As shown, the temperature inside the fermenter 1 is detected by the temperature sensor 41. When the temperature inside the tank drops to the inoculation temperature, the control unit 13 controls the first electric push rod 24 to retract, the inoculation tube 2 moves upward and drives the sliding column 233 on the plug 231 to disengage from the drive shaft 31. Under the action of the spring 232, the plug 231 seals the discharge port 23. When the inoculation tube 2 drives the inoculum outlet 21 into the storage tank 12, the inoculum suspension in the storage tank 12 flows naturally into the inoculation tube 2 under the action of gravity. Compared with the existing technology, this method... The pump-assisted inoculation method of this invention makes the inoculation process gentler, which is conducive to improving the integrity and survival rate of the inoculated bacteria. The bacterial suspension fills the inner cavity of the inoculation tube 2. Repeating the above process can achieve the effect of multiple quantitative inoculations. Then, the first electric push rod 24 is controlled to extend and reset, the inoculation tube 2 moves down and reset, and triggers the sealing component to open the discharge port 23, so that the bacterial suspension falls into the fermentation tank 1. Since the fermentation tank 1 and the storage tank 12 are separated by the inoculation tube 2, the two will not be directly connected, thus avoiding backflow during inoculation. In addition, the probe of the temperature sensor 41 is suspended inside the partition sleeve 4 to avoid the temperature sensor 41 from being distorted due to the high temperature inside the fermenter 1. The heat-conducting rod 42 extends to the bottom of the fermenter 1 and can transfer the temperature of the inner layer of raw materials at the bottom of the tank to the partition sleeve 4, so that the temperature sensor 41 detects a value close to the actual temperature of the inner layer of raw materials. Since the inner layer of raw materials cools down slowly, this structure avoids the situation of inoculation when the inner layer temperature is too high, further ensuring the survival rate of the strain. After the raw materials are added, the liquid level of the raw materials in the fermentation tank 1 is checked by the ultrasonic level gauge 55. When the level is higher than the threshold, it indicates that the liquid level of the raw materials in the tank is high and the amount of raw materials is large. At this time, the control unit 13 controls the second electric push rod 53 to retract. The second electric push rod 53 drives the sleeve 32 to move upward. The sleeve 32 drives the stirring paddle 322 to move upward, thereby adjusting the relative position of the stirring paddle 322 and the liquid level of the raw materials to avoid the situation where the upper layer of raw materials cannot be stirred. At the same time, the sleeve 32 drives the mounting frame 5 to move upward synchronously. The mounting frame 5 pulls the slide 52 closer to the inoculation tube 2 through the connecting rod 51. The slide 52 drives the heat-conducting rod 42 closer to the center of the fermentation tank 1. The slide 52 pushes the piston 221 to slide through the heat-conducting rod 42. The piston 221 slides to the outer end of the expansion tube 22, thereby increasing the volume inside the expansion tube 22. Since the expansion tube 22 is connected to the inoculation tube 2, the overall internal volume of the inoculation tube 2 is increased, thereby achieving the effect of increasing the inoculation amount while increasing the amount of raw materials. And, as Figure 3 As shown, the slide 52 drives the heat-conducting rod 42 to move closer to the center of the fermenter 1, so that the heat-conducting rod 42 can transfer the temperature of the raw material near the center of the tank to the partition sleeve 4, ensuring the reliability of the temperature measuring component and avoiding the situation where the temperature of the inner raw material is too high, resulting in a decrease in the survival rate of the strain. During inoculation, motor 3 is started. Motor 3 drives sleeve 32 to rotate through transmission shaft 31. Sleeve 32 drives guide frame 321 and stirring paddle 322 to rotate. The inoculum suspension discharged from inoculation tube 2 diffuses along the rotating guide frame 321 to the periphery of fermenter 1, which helps to improve the uniformity of inoculation and prevents the inoculum suspension from settling in the center of fermenter 1. At the same time, stirring paddle 322 promotes the mixing of raw materials and inoculum suspension, which helps to improve fermentation efficiency.

[0030] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A fermentation reaction apparatus for veterinary drug production raw materials, comprising a fermenter (1) and a lid (11) fixed to the top of the fermenter (1), characterized in that: A culture storage tank (12) is provided on the top outer wall of the tank lid (11), and a control unit (13) is provided on the outer wall of the fermentation tank (1). An inoculation port (121) communicating with the fermentation tank (1) is opened on the bottom inner wall of the culture storage tank (12). An inoculation tube (2) is slidably connected inside the inoculation port (121). An expansion tube (22) communicating with the inoculation tube (2) is provided on the side wall of the inoculation tube (2). A culture collection port (21) is opened at the top of the inoculation tube (2). The bottom end is provided with a discharge port (23), and a sealing component is provided inside the discharge port (23). A first electric push rod (24) for driving the inoculation tube (2) to slide up and down is fixedly installed on the outer wall of the storage tank (12). A temperature measuring component is provided inside the fermentation tank (1). When the temperature inside the fermentation tank (1) drops to the appropriate inoculation temperature, the temperature measuring component triggers the extension and retraction of the first electric push rod (24). The first electric push rod (24) drives the inoculation tube (2) into the storage tank (12) and collects a certain amount of bacterial suspension. A motor (3) is fixedly installed on the bottom outer wall of the fermenter (1). The output end of the motor (3) is fixed with a drive shaft (31) extending to the bottom of the inoculation tube (2). Whenever the inoculation tube (2) moves down and resets, the drive shaft (31) triggers the sealing component and opens the discharge port (23). A stirring component is provided on the drive shaft (31) and rotates with the drive shaft (31). The bacterial suspension discharged from the discharge port (23) diffuses into the fermenter (1) through the stirring component. An adjustment component is provided in the fermenter (1). When the raw material liquid level in the fermenter (1) rises, the adjustment component drives the stirring component to move up along the drive shaft (31) and increases the internal volume of the expansion tube (22).

2. The fermentation reaction equipment for veterinary drug production raw materials according to claim 1, characterized in that: The temperature measuring assembly includes a spacer (4) fixed on the inner wall of the tank lid (11), a temperature sensor (41) fixed on the outer wall of the tank lid (11), the probe of the temperature sensor (41) inserted into the spacer (4), a heat-conducting rod (42) slidably connected on the outer wall of the spacer (4), the end of the heat-conducting rod (42) away from the spacer (4) extending to the bottom of the fermenter (1), and the first electric push rod (24) and the control unit (13) being electrically connected by the temperature sensor (41).

3. The fermentation reaction equipment for veterinary drug production raw materials according to claim 2, characterized in that: The output end of the first electric push rod (24) is fixed with a first support rod (241) extending into the fermenter (1), and the end of the first support rod (241) away from the first electric push rod (24) is fixed on the outer wall of the expansion tube (22).

4. The fermentation reaction equipment for veterinary drug production raw materials according to claim 1, characterized in that: The sealing assembly includes a plug (231) that is slidably inserted into the feed port (23). A spring (232) is provided between the outer wall of the plug (231) and the inner wall of the inoculation tube (2). A sliding column (233) extending to the outside of the inoculation tube (2) is provided on the outer wall of the plug (231).

5. The fermentation reaction equipment for veterinary drug production raw materials according to claim 1, characterized in that: The stirring assembly includes a sleeve (32) that is slidably sleeved on the outer wall of the drive shaft (31). A guide frame (321) located below the inoculation tube (2) is fixed on the outer wall of the sleeve (32). A stirring paddle (322) is fixed on the outer wall of the bottom end of the sleeve (32). A limiting groove is extended axially on the outer wall of the drive shaft (31). A limiting block that docks with the limiting groove is provided on the inner wall of the sleeve (32).

6. The fermentation reaction equipment for veterinary drug production raw materials according to claim 1, characterized in that: The adjustment assembly includes a mounting bracket (5) rotatably connected to the top of the sleeve (32). A second support rod (531) extending to the outside of the tank cover (11) is fixed on the outer wall of the mounting bracket (5). A second electric push rod (53) is fixed on the outer wall of the storage tank (12). The output end of the second electric push rod (53) is fixed to the end of the second support rod (531). An ultrasonic level sensor (55) is fixedly installed on the outer wall of the tank cover (11). The second electric push rod (53) and the control unit (13) are electrically connected by the ultrasonic level sensor (55).

7. The fermentation reaction equipment for veterinary drug production raw materials according to claim 6, characterized in that: The fermenter (1) is provided with a slide rail (54) on its inner wall. A slide seat (52) is slidably connected inside the slide rail (54). A connecting rod (51) is rotatably connected to the outer wall of the slide seat (52). The end of the connecting rod (51) away from the slide seat (52) is rotatably connected to the outer wall of the mounting frame (5).

8. The fermentation reaction equipment for veterinary drug production raw materials according to claim 7, characterized in that: The slide block (52) is slidably sleeved on the outer wall of the heat-conducting rod (42). A piston (221) is slidably connected inside the expansion tube (22). A slide rod (222) extending to the outside of the inoculation tube (2) is provided on the outer wall of the piston (221). The slide rod (222) is slidably sleeved on the outer wall of the heat-conducting rod (42).

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