Use of exosome circmtcl1 in preparation of products for diagnosis and treatment of glioblastoma
CN122484287BActive Publication Date: 2026-10-16ANHUI PROVINCIAL HOSPITAL
Patent Information
- Application Number
- CN202610923298.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2026-06-25
- Publication Date
- 2026-10-16
- Estimated Expiration
- 2046-06-25
AI Technical Summary
Technical Problem
[0004]然而，目前现有技术中尚缺乏以血浆来源外泌体中的circRNA作为分子标志物来无创诊断胶质瘤以及胶质母细胞瘤的有效方法；此外，尽管已知circRNA具有优于线性RNA的稳定性，但尚未见到利用胶质母细胞瘤干细胞自身来源的外泌体对特定功能性circRNA进行封装，并回输用于胶质瘤细胞治疗的相关报道
Benefits of technology
（1）本申请提供了针对血浆外泌体circMTCL1的体外检测工具，通过对其BSJ的特异识别，可实现对胶质瘤，尤其是胶质母细胞瘤的辅助诊断及病理分层判断，对于临床上胶质瘤的诊断具有重要意义。
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Figure CN122484287B_ABST
Abstract
The application discloses application of exosome circMTCL1 in preparation of products for diagnosis and treatment of glioblastoma, and belongs to the field of biomedical detection and biomedicine technology. The application discloses and verifies that circMTCL1 in plasma exosomes can be used as a biomarker for diagnosis of glioma, and treatment of glioblastoma can be realized by delivering circMTCL1 through exosomes, thereby providing a new scheme for diagnosis and treatment of glioblastoma in clinic and realizing diagnosis and treatment integration of glioblastoma in clinic.
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Citation Information
Patent Citations
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