A heparin and early warning protein evaluation and analysis device

Abstract

This application provides a heparin and early warning protein assessment and analysis device, relating to the field of heparin and protein analysis. The device includes a body with a sample inlet / outlet module. The module includes a base plate, on which a reciprocating linear motion mechanism is mounted. A sample placement stage is mounted on the reciprocating linear motion mechanism, and a sample placement seat is elastically mounted on the sample placement stage along its vertical direction. The bottom end of the sample placement seat has an outwardly convex arc-shaped protrusion. A camshaft located below the arc-shaped protrusion is mounted on the base plate. During its rotation, the camshaft compresses the arc-shaped protrusion, causing it to move upward. This application integrates an oscillation function into the sample inlet / outlet module, achieving sample oscillation operation. This solves the problem in existing heparin dose assessment and analysis devices that lack integrated sample oscillation functionality, requiring external independent oscillation equipment and manual sample transfer, resulting in cumbersome operation procedures and low detection efficiency.

Description

Technical Field

[0001] This invention relates to the field of heparin and protein analysis, and more specifically, to a heparin and early warning protein assessment and analysis device. Background Technology

[0002] Heparin is a widely used anticoagulant in clinical practice, and its dosage needs to be strictly calculated based on the patient's weight and treatment goals. Protamine sulfate, on the other hand, is a heparin antagonist; each 1 mg precisely antagonizes 100 units of heparin, used to neutralize excess heparin and reduce the risk of postoperative bleeding. During heparin therapy, clinicians not only need to monitor activated partial thromboplastin time (APTT) to assess overall coagulation status, but also need to quantitatively assess the required heparin dosage and the amount of residual heparin after neutralization with protamine sulfate to ensure the safety and effectiveness of the medication.

[0003] Current technologies primarily utilize heparin dose assessment analyzers to analyze heparin and protein dosages. Before testing, sample preparation is required. Patient anticoagulated blood samples are divided into multiple subsamples, each containing a different concentration of heparin solution to create a gradient dose sample (e.g., corresponding to 0, 1 mg / kg, 2 mg / kg, 3 mg / kg, and 4 mg / kg heparin doses). After adding heparin to each sample, it must be thoroughly shaken and allowed to stand for 5 to 10 minutes to allow sufficient reaction between the heparin and blood components. Subsequently, protamine sulfate neutralizing solution and calcium chloride solution are added sequentially to the heparin-containing samples, and after repeated mixing, the samples are placed into the analyzer for testing. Heparin dosage or residual levels are assessed by measuring parameters such as clotting time in each sample. However, most existing heparin dose assessment analyzers lack integrated sample shaking functionality. Operators must rely on external, separate shaking equipment, making the process cumbersome and dependent on manual external shaking and sample transfer, increasing manual operation and reducing testing efficiency.

[0004] Therefore, we have made improvements to this by proposing a heparin and early warning protein assessment and analysis device. Summary of the Invention

[0005] The purpose of this invention is to address the problem that most existing heparin dose assessment and analysis devices lack integrated sample oscillation functions, requiring operators to use external oscillation devices, which is cumbersome and relies on manual operation for external oscillation and sample transfer, increasing manual operation steps and reducing detection efficiency.

[0006] To achieve the above-mentioned objectives, the present invention provides a heparin and early warning protein assessment and analysis device to improve the aforementioned problems.

[0007] The application is as follows: A heparin and early warning protein assessment and analysis device includes a body with a sample inlet and outlet on one side. A sample inlet / outlet module is disposed within the body, opposite to the sample inlet and outlet. The sample inlet / outlet module includes a base plate, on which a reciprocating linear motion mechanism is mounted. A sample placement stage is mounted on the reciprocating linear motion mechanism, opposite to the sample inlet and outlet. A sample placement seat is elastically mounted on the sample placement stage along its vertical direction. The bottom end of the sample placement seat has an outwardly convex arc-shaped protrusion. A camshaft located below the arc-shaped protrusion is mounted on the base plate. During rotation, the camshaft compresses the arc-shaped protrusion, causing it to move upward.

[0008] As a preferred technical solution of this application, the reciprocating linear motion mechanism includes a first support plate installed at the inner end of the substrate and a second support plate installed at the outer end of the substrate. A positive and negative lead screw is rotatably installed between one side end of the first support plate and the second support plate, and a guide rod is fixedly installed between the other side end. A slide is adapted to be installed on the positive and negative lead screw and the guide rod. A driving member that is transmittedly connected to the end of the positive and negative lead screw is installed on one side of the inner end of the substrate.

[0009] As a preferred technical solution of this application, the camshaft is rotatably mounted at the bottom position between the first support plate and the second support plate, and the middle part of the camshaft has a raised ridge. The bottom ends of the arc-shaped protrusion are provided with arc surfaces opposite to the raised ridge. The end of the camshaft is connected to the positive and negative lead screws through an internal ratchet mechanism.

[0010] As a preferred technical solution of this application, the internal ratchet mechanism includes an internal ratchet and a pawl disc arranged coaxially. A third support plate is fixedly installed on the base plate outside the first support plate. The ends of the positive and negative lead screws extend to the outside of the third support plate and are fixedly connected to the pawl disc. Multiple active pawls are annularly hinged on the outer side of the pawl disc. A first elastic reset member is installed on the inner side of the pawl disc and abuts against the inner side of the active pawl. The pawl disc is rotatably mounted on the third support plate and is drivenly connected to the end of the camshaft. Multiple pawl grooves are opened on the inner side of the internal ratchet along its circumference, and the active pawls are adapted to abut against the pawl grooves.

[0011] As a preferred technical solution of this application, the end of the camshaft passes through the third support plate and is equipped with a driven gear, a gear ring is fixedly installed on the outer side of the inner ratchet, and a transmission gear that meshes with the driven gear and the gear ring is installed on the third support plate.

[0012] As a preferred technical solution of this application, pulleys are installed on the positive and negative lead screws at the positions between the first support plate and the third support plate and at the output end of the drive component, and a transmission belt is installed on the two pulleys.

[0013] As a preferred technical solution of this application, the sample placement stage is fixedly installed on the slide and its outer end extends outside the slide. The outer end of the sample placement stage is provided with a mounting groove, and the sample placement seat is adapted to be installed in the mounting groove. The top of the slide has a protrusion, and the opposite side of the sample placement stage has a stepped surface adapted to be installed with the protrusion.

[0014] As a preferred technical solution of this application, the top of the inner end of the sample placement stage is provided with a connecting groove that matches the mounting groove, the inner side of the sample placement seat is provided with an extension that matches the connecting groove, the bottom of the extension is provided with a downwardly extending connecting part, the arc-shaped protrusion is fixed to the bottom end of the connecting part, the bottom of the connecting groove is provided with a first connecting port for the connecting part to pass through, and the middle of the slide is provided with a second connecting port for the connecting part to pass through.

[0015] As a preferred technical solution of this application, the bottom of the mounting groove is provided with an insertion hole, the bottom of the sample placement seat has a protrusion that is inserted and connected to the insertion hole, the bottom end of the protrusion is fixed with a limit block, and a second elastic reset member is installed between the limit block and the bottom end of the sample placement stage.

[0016] As a preferred technical solution of this application, a first clamping seat is fixed on one side of the top of the sample placement seat, and a sliding groove is provided on the other side of the top of the sample placement seat. A sliding plate is slidably disposed in the sliding groove, and a second clamping seat is fixed on the top of the sliding plate. A set of through straight slots is provided on the side of the mounting groove. A sliding rod passing through the straight slots is installed on the inner side of the sliding groove. The sliding plate and the sliding rod are interlocked and connected, and a third elastic reset member is installed between its side and the inner wall of the sliding groove. A threaded rod passing through one of the straight slots is installed on the side of the sample placement seat, and the inner end of the threaded rod is located in the sliding groove.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: In the scheme of this application: By incorporating a reciprocating linear motion mechanism and a camshaft on the sample inlet / outlet module, and installing a sample placement stage on the reciprocating linear motion mechanism, a sample placement seat is elastically mounted on the sample placement stage. The independent movement of the reciprocating linear motion mechanism drives the sample placement seat to perform linear reciprocating motion, achieving the purpose of sample entry and exit from the machine during detection. During the continuous movement of the reciprocating linear motion mechanism, the camshaft is simultaneously driven to rotate, causing the camshaft to periodically squeeze the arc-shaped protrusion upwards. Thus, based on the horizontal cyclic linear reciprocating motion of the sample placement seat, intermittent vertical oscillation is synchronously superimposed, achieving rapid and uniform oscillation and mixing of the sample on the sample placement seat. By integrating the oscillation function into the sample inlet / outlet module, the oscillation operation of the sample is realized, solving the problem that existing heparin dose assessment and analysis equipment lacks integrated sample oscillation function, requiring the use of external independent oscillation equipment and manual sample transfer, resulting in cumbersome operation procedures and low detection efficiency. Attached Figure Description

[0018] Figure 1 A schematic diagram of the structure of the heparin and early warning protein assessment and analysis device provided in this application; Figure 2 A schematic diagram of one end of the sample inlet / outlet module of the heparin and early warning protein assessment and analysis device provided in this application; Figure 3 A schematic diagram of the other end of the sample inlet / outlet module of the heparin and early warning protein assessment and analysis device provided in this application; Figure 4 A schematic diagram of the internal ratchet mechanism of the heparin and early warning protein assessment and analysis device provided in this application located on the substrate; Figure 5 A front view of the inner ratchet mechanism on the third support plate of the heparin and early warning protein assessment and analysis device provided in this application; Figure 6 A schematic diagram showing the separation of the sample placement stage and slide of the heparin and early warning protein assessment and analysis device provided in this application; Figure 7 A schematic diagram of the structure in which the second clamping seat of the heparin and early warning protein assessment and analysis device provided in this application is separated from the sample placement seat; Figure 8 A schematic diagram of the sample placement stage of the heparin and early warning protein assessment and analysis device provided in this application; Figure 9 A schematic diagram of the camshaft of the heparin and early warning protein assessment and analysis device provided in this application; Figure 10 A schematic diagram of the bottom of the sample placement stage of the heparin and early warning protein assessment and analysis device provided in this application.

[0019] The image shows: 100. Body; 101. Sample inlet / outlet; 200. Base plate; 201. First support plate; 202. Second support plate; 203. Positive and negative lead screws; 204. Guide rod; 205. Slide block; 2051. Protrusion; 2052. Second connection port; 206. Driving component; 207. Pulley; 208. Transmission belt; 300. Sample placement stage; 3001. Stepped surface; 3002. Mounting groove; 3003. Connecting groove; 3004. First connecting port; 3005. Through hole; 3006. Straight groove; 301. Sample placement seat; 3011. Extension; 3012. Connecting part; 3013. Arc-shaped protrusion; 3014. Protruding post; 3015. Limiting block; 3016. Second elastic reset element; 3017. Slide groove; 302. First clamping seat; 3021. Slide plate; 3022. Second clamping seat; 3023. Slide rod; 303. Third elastic reset element; 304. Threaded rod; 400, Camshaft; 401, Rib; 402, Inner Ratchet; 4021, Pad Groove; 403, Pad Disc; 404, Third Support Plate; 405, Driving Pad; 406, First Elastic Reset Member; 407, Driven Gear; 408, Gear Ring; 409, Transmission Gear. Detailed Implementation

[0020] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0021] The present invention will be further described below with reference to embodiments.

[0022] Example: Refer to Figures 1 to 10 As shown, a heparin and early warning protein assessment and analysis device includes a body 100. A sample inlet / outlet 101 is provided on one side of the body 100. A sample inlet / outlet module is provided inside the body 100, which is opposite to the sample inlet / outlet 101. The body 100 also integrates modules for triaxial sampling and pipetting, reagent card delivery and detection, and sampling needle cleaning, so as to realize the relevant detection process such as sample loading, pipetting, reaction incubation, result detection and sampling needle cleaning. This is a mature technology in this field and will not be described in detail here.

[0023] To address the problem that most existing heparin dose assessment and analysis devices lack integrated sample oscillation functionality and rely on external independent oscillation devices and manual sample transfer, resulting in cumbersome processes and low efficiency, this application improves the sample inlet / outlet module. Specifically, the sample inlet / outlet module includes a base plate 200, on which a reciprocating linear motion mechanism is mounted, and on which a sample placement stage 300 is mounted. The sample placement stage 300 is opposite to the sample inlet / outlet 101, and a sample placement seat 301 is elastically mounted on the sample placement stage 300 along its vertical direction. The bottom end of the sample placement seat 301 has an outwardly protruding arc-shaped protrusion 3013, and a camshaft 400 located below the arc-shaped protrusion 3013 is mounted on the base plate 200. The above structure allows for switching between two working modes: sample entry / exit and oscillation. In the sample loading and unloading mode, the reciprocating linear motion mechanism drives the sample placement seat 301 to perform unidirectional linear loading and unloading motion, while the camshaft 400 remains stationary, thus achieving stable sample loading and unloading. In oscillation mode, the reciprocating linear motion mechanism drives the sample placement seat 301 to perform a horizontal cyclic linear reciprocating motion, while simultaneously driving the camshaft 400 to rotate, causing the camshaft 400 to periodically squeeze the arc-shaped protrusion 3013 upward. Thus, on the basis of the horizontal cyclic linear reciprocating motion, intermittent vertical oscillation is simultaneously superimposed. This combined horizontal reciprocating and vertical oscillation motion acts on the sample in the sample placement seat 301, achieving rapid and uniform oscillation and mixing.

[0024] Furthermore, the reciprocating linear motion mechanism includes a first support plate 201 installed at the inner end of the substrate 200 and a second support plate 202 installed at the outer end of the substrate 200. A forward and reverse lead screw 203 is rotatably installed between one end of the first support plate 201 and the second support plate 202, and a guide rod 204 is fixedly installed between the other ends. A slide block 205 is adapted to be installed on the forward and reverse lead screw 203 and the guide rod 204. A drive member 206 is installed on one side of the inner end of the substrate 200 and is connected to the end of the forward and reverse lead screw 203. The drive member 206 drives the forward and reverse lead screw 203 to rotate in the forward or reverse direction, which can drive the slide block 205 and the sample placement stage 300 fixed thereon to perform linear reciprocating motion along the guide rod 204.

[0025] To achieve selective control of the rotation direction of the positive and negative lead screw 203 on the oscillation function, the camshaft 400 is rotatably installed at the bottom position between the first support plate 201 and the second support plate 202, and the middle part of the camshaft 400 has a raised ridge 401, and the bottom ends of the arc-shaped protrusion 3013 are provided with arc surfaces opposite to the ridge 401. The end of the camshaft 400 is connected to the positive and negative lead screw 203 through an internal ratchet mechanism. The internal ratchet mechanism includes an internal ratchet 402 and a pawl disc 403 coaxially arranged. A third support plate 404 is fixedly mounted on the base plate 200 outside the first support plate 201. The ends of the positive and negative lead screws 203 extend outside the third support plate 404 and are fixedly connected to the pawl disc 403. Multiple active pawls 405 are annularly hinged at equal intervals on the outer side of the pawl disc 403. A first elastic reset member 406 is installed on the inner side of the pawl disc 403, which abuts against the inner side of the active pawls 405. The pawl disc 403 rotates. The inner ratchet 402 is mounted on the third support plate 404 and is connected to the end of the camshaft 400. Multiple pawl grooves 4021 are provided on the inner side of the inner ratchet 402 along its circumference. The driving pawl 405 is adapted to and abuts against the pawl grooves 4021. The end of the camshaft 400 passes through the third support plate 404 and is equipped with a driven gear 407. A gear ring 408 is fixedly mounted on the outer side of the inner ratchet 402. A transmission gear 409 that meshes with the driven gear 407 and the gear ring 408 is mounted on the third support plate 404.

[0026] Preferably, pulleys are installed on the positive and negative lead screws 203 at the position between the first support plate 201 and the third support plate 404 and at the output end of the drive unit 206. The two pulleys are equipped with transmission belts 208. The drive unit 206 is preferably a stepper motor or a servo motor. Its control cable is electrically connected to the main control circuit board inside the machine body 100. The main control circuit board controls the rotation direction, speed and number of rotations of the drive unit 206 by sending pulse signals to the drive unit 206, thereby precisely controlling the rotation direction and rotation amount of the positive and negative lead screws 203, so as to realize the unidirectional linear displacement control in the sample feeding mode and the cyclic reciprocating motion amplitude and frequency control in the oscillation mode.

[0027] In specific implementation, Figure 4 and Figure 5 For example, the internal ratchet mechanism acts as a one-way clutch. When the forward and reverse screws 203 rotate clockwise, the active pawl 405 in the internal ratchet mechanism slips with the pawl groove 4021 of the internal ratchet 402, and the power is not transmitted to the camshaft 400. The camshaft 400 remains stationary. At this time, the slide 205 only drives the sample placement seat 301 to make a unidirectional linear in-and-out movement without vertical oscillation, thereby ensuring the stability of the sample picking and placing process. When the lead screw 203 rotates counterclockwise, the active pawl 405 on the pawl disc 403 is engaged in the pawl groove 4021 of the inner ratchet 402 and drives the inner ratchet 402 to rotate synchronously. The power is transmitted to the camshaft 400 through the gear ring 408, the transmission gear 409 and the driven gear 407, driving the camshaft 400 to rotate synchronously. During this process, the slide 205 drives the sample placement seat 301 to perform a horizontal cyclic linear reciprocating motion. At the same time, the rotating convex rib 401 periodically presses against the arc-shaped protrusion 3013, forcing the sample placement seat 301, which is elastically mounted on the sample placement stage 300, to synchronously superimpose intermittent high-frequency small-amplitude vertical oscillations during the horizontal reciprocating motion. This horizontal cyclic reciprocating motion causes the sample to generate continuous horizontal flow and tumbling in the reaction tube, while the synchronously superimposed vertical oscillations continuously change the shear direction of the sample. The combined effect of the two makes the components of the sample fully and uniformly mixed within a preset time, improving the mixing efficiency.

[0028] Meanwhile, the internal ratchet mechanism allows the entire sample entry and exit module to be driven by only a single drive source. By switching the rotation direction of the forward and reverse lead screws 203, the coordinated control of two functions—smooth sample entry and exit and composite oscillation and mixing—is achieved, ensuring the independence and reliability of the functions.

[0029] Preferably, when the slide 205 is located at both ends of the positive and negative lead screw 203, the protrusion 401 on the camshaft 400 is located below the arc-shaped protrusion 3013 to facilitate the switching between the two working modes.

[0030] Preferably, the sample placement stage 300 is fixedly mounted on the slide 205 and its outer end extends beyond the slide 205. The outer end of the sample placement stage 300 is provided with a mounting groove 3002. The sample placement seat 301 is adapted to be installed in the mounting groove 3002. The sample placement seat 301 can move vertically along the mounting groove 3002. The top of the slide 205 has a protrusion 2051. The opposite side of the sample placement stage 300 has a stepped surface 3001 that is adapted to be installed with the protrusion 2051, thereby improving the stability of the sample placement stage 300 and the slide 205.

[0031] Preferably, the inner top of the sample placement stage 300 is provided with a connecting groove 3003 that matches the mounting groove 3002. The inner side of the sample placement seat 301 has an extension 3011 that matches the connecting groove 3003. The bottom of the extension 3011 has a downwardly extending connecting part 3012. The arc-shaped protrusion 3013 is fixed to the bottom of the connecting part 3012. The bottom of the connecting groove 3003 is provided with a first connecting port 3004 for the connecting part 3012 to pass through. The middle of the slide 205 is provided with a second connecting port 2052 for the connecting part 3012 to pass through. The connecting part 3012 passes through the first connecting port 3004 and the second connecting port 2052, so that the arc-shaped protrusion 3013 is accurately positioned above the camshaft 400, providing precise guidance for vertical oscillation.

[0032] Preferably, the bottom of the mounting groove 3002 is provided with an insertion hole 3005, and the bottom of the sample placement seat 301 has a protrusion 3014 that is inserted and connected to the insertion hole 3005. The bottom end of the protrusion 3014 is fixed with a limiting block 3015. A second elastic reset member 3016 is installed between the limiting block 3015 and the bottom end of the sample placement stage 300. The second elastic reset member 3016 enables the sample placement seat 301 to quickly reset after the protrusion 401 separates from the arc-shaped protrusion 3013, forming a continuous and stable intermittent oscillation.

[0033] Preferably, a first clamping seat 302 is fixed to one side of the top of the sample placement seat 301, and a sliding groove 3017 is provided on the other side of the top of the sample placement seat 301. A sliding plate 3021 is slidably disposed in the sliding groove 3017, and a second clamping seat 3022 is fixed to the top of the sliding plate 3021. The second clamping seat 3022 slides relative to the first clamping seat 302. A set of through straight slots 3006 is provided on the side of the mounting groove 3002, and a sliding rod 3023 passing through the straight slots 3006 is installed on the inner side of the sliding groove 3017. The sliding rod 3023 can move with the sample placement seat. 301 slides vertically within the straight slot 3006. The slide plate 3021 is interlocked with the slide rod 3023, and a third elastic reset member 303 is installed between its side and the inner wall of the slide groove 3017. A threaded rod 304 passing through one of the straight slots 3006 is installed on the side of the sample placement seat 301. The inner end of the threaded rod 304 is located within the slide groove 3017. The threaded rod 304 is used to fix the position of the second clamping seat 3022, so that the position of the test tube rack placed between the first clamping seat 302 and the second clamping seat 3022 is fixed, so as to allow the sample to enter and exit for testing or vibration.

[0034] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0035] Obviously, the embodiments described above are merely some embodiments of the present invention, not all embodiments. The accompanying drawings show preferred embodiments of the present invention, but do not limit the patent scope of the present invention. The present invention can be implemented in many different forms; rather, these embodiments are provided to provide a more thorough and complete understanding of the disclosure of the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing specific embodiments, or make equivalent substitutions for some of the technical features. Any equivalent structures made using the content of this specification and drawings, directly or indirectly applied to other related technical fields, are similarly within the patent protection scope of this invention.

Claims

1. A heparin and early warning protein assessment and analysis device, comprising a body (100), wherein a sample inlet / outlet (101) is provided on one side of the body (100), and a sample inlet / outlet module is provided inside the body (100) opposite to the sample inlet / outlet (101), characterized in that, The sample inlet / outlet module includes a base plate (200), on which a reciprocating linear motion mechanism is mounted, and a sample placement stage (300) is mounted on the reciprocating linear motion mechanism. The sample placement stage (300) is opposite to the sample inlet / outlet (101). A sample placement seat (301) is elastically mounted on the sample placement stage (300) along its vertical direction. The bottom end of the sample placement seat (301) has an outwardly protruding arc-shaped protrusion (3013). A camshaft (400) located below the arc-shaped protrusion (3013) is mounted on the base plate (200). During the rotation of the camshaft (400), it squeezes the arc-shaped protrusion (3013) to move upward.

2. The heparin and early warning protein assessment and analysis device according to claim 1, characterized in that, The reciprocating linear motion mechanism includes a first support plate (201) installed at the inner end of the substrate (200) and a second support plate (202) installed at the outer end of the substrate (200). A positive and negative lead screw (203) is rotatably installed between one side end of the first support plate (201) and the second support plate (202), and a guide rod (204) is fixedly installed between the other side end. A slide (205) is adapted to be installed on the positive and negative lead screw (203) and the guide rod (204). A drive member (206) that is transmittedly connected to the end of the positive and negative lead screw (203) is installed on one side of the inner end of the substrate (200).

3. The heparin and early warning protein assessment and analysis device according to claim 2, characterized in that, The camshaft (400) is rotatably mounted at the bottom position between the first support plate (201) and the second support plate (202), and the camshaft (400) has a raised ridge (401) in the middle. The arc-shaped protrusion (3013) has arc surfaces at both ends at the bottom that are opposite to the ridge (401). The end of the camshaft (400) is connected to the positive and negative lead screw (203) through an internal ratchet mechanism.

4. The heparin and early warning protein assessment and analysis device according to claim 3, characterized in that, The internal ratchet mechanism includes an internal ratchet (402) and a pawl disc (403) arranged coaxially. A third support plate (404) is fixedly installed on the base plate (200) on the outside of the first support plate (201). The end of the positive and negative lead screw (203) extends to the outside of the third support plate (404) and is fixedly connected to the pawl disc (403). Multiple active pawls (405) are annularly hinged on the outside of the pawl disc (403). A first elastic reset member (406) is installed on the inside of the pawl disc (403) and abuts against the inside of the active pawl (405). The pawl disc (403) is rotatably mounted on the third support plate (404) and is connected to the end of the camshaft (400). Multiple pawl grooves (4021) are opened on the inner side of the internal ratchet (402) along its circumference. The active pawl (405) is adapted to abut against the pawl grooves (4021).

5. The heparin and early warning protein assessment and analysis device according to claim 4, characterized in that, The end of the camshaft (400) passes through the third support plate (404) and is fitted with a driven gear (407). A gear ring (408) is fixedly installed on the outer side of the inner ratchet (402). A transmission gear (409) that meshes with the driven gear (407) and the gear ring (408) is installed on the third support plate (404).

6. The heparin and early warning protein assessment and analysis device according to claim 5, characterized in that, The positive and negative lead screws (203) are equipped with pulleys (207) located between the first support plate (201) and the third support plate (404) and at the output end of the drive unit (206). A transmission belt (208) is installed on the two pulleys (207).

7. The heparin and early warning protein assessment and analysis device according to claim 6, characterized in that, The sample placement stage (300) is fixedly installed on the slide (205) and its outer end extends outside the slide (205). The outer end of the sample placement stage (300) is provided with a mounting groove (3002). The sample placement seat (301) is adapted to be installed in the mounting groove (3002). The top of the slide (205) has a protrusion (2051). The opposite side of the sample placement stage (300) has a stepped surface (3001) adapted to be installed with the protrusion (2051).

8. The heparin and early warning protein assessment and analysis device according to claim 7, characterized in that, The sample placement stage (300) has a connecting groove (3003) at the top of its inner end that is adapted to the mounting groove (3002). The sample placement seat (301) has an extension (3011) on its inner side that is adapted to the connecting groove (3003). The bottom of the extension (3011) has a downwardly extending connecting part (3012). The arc-shaped protrusion (3013) is fixed to the bottom of the connecting part (3012). The bottom of the connecting groove (3003) has a first connecting port (3004) for the connecting part (3012) to pass through. The middle of the slide (205) has a second connecting port (2052) for the connecting part (3012) to pass through.

9. The heparin and early warning protein assessment and analysis device according to claim 8, characterized in that, The bottom of the mounting groove (3002) is provided with an insertion hole (3005), and the bottom of the sample placement seat (301) has a protrusion (3014) that is inserted and connected to the insertion hole (3005). A limit block (3015) is fixed at the bottom end of the protrusion (3014), and a second elastic reset member (3016) is installed between the limit block (3015) and the bottom end of the sample placement stage (300).

10. The heparin and early warning protein assessment and analysis device according to claim 9, characterized in that, A first clamping seat (302) is fixed to one side of the top of the sample placement seat (301), and a sliding groove (3017) is provided on the other side of the top of the sample placement seat (301). A sliding plate (3021) is slidably disposed in the sliding groove (3017), and a second clamping seat (3022) is fixed to the top of the sliding plate (3021). A set of through straight slots (3006) is provided on the side of the mounting groove (3002), and the inner side of the sliding groove (3017) The sample holder (301) is equipped with a slide rod (3023) that passes through the straight slot (3006). The slide plate (3021) is interlocked with the slide rod (3023), and a third elastic reset member (303) is installed between its side and the inner wall of the slide groove (3017). The sample holder (301) is equipped with a threaded rod (304) that passes through one of the straight slots (3006) on its side. The inner end of the threaded rod (304) is located in the slide groove (3017).

Images