A human respiratory motion simulation lung model based on polyurethane foam, its fabrication method and application.

Abstract

This invention discloses a human respiratory motion simulation lung model based on polyurethane foam, its fabrication method, and its applications. The lung model includes an outer silicone coating layer, an inner foam filling layer, a lung airway model, and a tumor model. By using silicone and polyurethane foam, this invention divides the human lung into inner and outer parts, simulating the external shape and internal tissues of the lung. Using flexible materials such as TPU, an open-source lung airway model with various tracheal and bronchial airways is 3D printed and inserted into the lung model during the foaming stage to simulate the airways of a real lung, further enhancing the simulation effect. This invention can simulate human respiratory motion by inflating and deflating the lung model using the lung airway model, and the tumor model embedded in the foam can realistically simulate the movement of a tumor during human respiration.

Description

Technical Field

[0001] This invention relates to the field of biomimetic models, and in particular to a human respiratory movement simulation lung model based on polyurethane foam, its manufacturing method, and its application. Background Technology

[0002] Most existing lung models are made of rigid materials, which can simulate the overall appearance of the lungs. Some can simulate the internal structure, but they cannot produce deformation, making them difficult to use for actual respiratory motion simulation. Some models are made of flexible materials with hollow cavities inside, simulating respiratory motion by inflating and deflating the lungs. However, this still differs from real human lung tissue and cannot simulate the movement of lung lesions such as tumors. Summary of the Invention

[0003] The technical problem to be solved by this invention is to address the shortcomings of the prior art by providing a human respiratory movement simulation lung model based on polyurethane foam, its manufacturing method, and its application. This invention divides the human lung into an outer silicone coating layer and an inner foam filling layer, and simulates a lung with a tumor by placing a tumor model inside the inner foam filling layer.

[0004] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In the first aspect of the present invention, a human respiratory movement simulation lung model based on polyurethane foam sponge is provided, comprising an outer silicone wrapping layer with a lung shape formed by silicone, an inner sponge filling layer formed by polyurethane foam sponge filled inside the outer silicone wrapping layer, and a lung airway model embedded in the inner sponge filling layer.

[0005] Preferably, the human respiratory motion simulation lung model based on polyurethane foam sponge also includes a tumor model embedded in the inner sponge filling layer.

[0006] Preferably, the tumor model is obtained by 3D printing using PLA (polylactic acid) material.

[0007] Preferably, the lung airway model is obtained by 3D printing using a flexible material.

[0008] Preferably, the flexible material is TPU (thermoplastic polyurethane elastomer).

[0009] A second aspect of the present invention also provides a method for fabricating a human respiratory movement simulation lung model based on polyurethane foam as described above, comprising the following steps: S1. Preparation of the outer silicone coating layer: Silicone is poured into the lung outer layer mold, and after solidification, an outer silicone coating layer with the shape of a lung is obtained by being clamped out through the lung outer layer mold. The top of the outer silicone coating layer is reserved with an infusion port that connects to the interior. S2. After squeezing and shrinking the lung airway model, insert it into the corresponding position in the outer silicone wrapping layer through the infusion port; S3. Preparation of the inner sponge filling layer: Pour polyurethane foam sponge into the outer silicone wrapping layer through the injection port, foam it into shape, and cut off the part that protrudes from the outer silicone wrapping layer, thereby filling the inner sponge filling layer inside the outer silicone wrapping layer.

[0010] Preferably, the method for fabricating the human respiratory movement simulation lung model based on polyurethane foam further includes the following steps: S4, embedding the tumor model into the corresponding position in the internal sponge filling layer through the infusion port to simulate a tumor.

[0011] Preferably, the solidification conditions in step S1 are: solidification at room temperature for 6-10 hours; and the foaming conditions in step S3 are: foaming at room temperature for 2-10 minutes.

[0012] Preferably, the two-component silicone in step S1 is Guoyuan silicone G10, and the two-component polyurethane foam in step S3 is Haibeisi polyurethane foam.

[0013] Preferably, the method for fabricating the human respiratory motion simulation lung model based on polyurethane foam sponge includes the following steps: S1. Preparation of the outer silicone coating layer: Mix and stir the A and B components of Guoyuan silicone G10 in a volume ratio of 1:1 and defoam under vacuum. Pour the mixture into the lung outer layer mold and solidify at room temperature for 8 hours to obtain an outer silicone coating layer with a lung shape that is clamped out through the lung outer layer mold. The top of the outer silicone coating layer is reserved with an infusion port that connects to the interior. S2. After squeezing and shrinking the lung airway model, insert it into the corresponding position in the outer silicone wrapping layer through the infusion port; S3. Preparation of the inner sponge filling layer: Mix component A and component B of Haibeis polyurethane foam sponge in a weight ratio of 5:2 and stir evenly. Then pour it into the outer silicone wrapping layer from the injection port. Foam and form at room temperature for 5 minutes. Cut off the part that protrudes from the outer silicone wrapping layer to fill the inner sponge filling layer inside the outer silicone wrapping layer. S3. Embed the tumor model into the corresponding position in the internal sponge filling layer through the infusion port to simulate a tumor.

[0014] A third aspect of the invention also provides the application of the lung model described above in simulating respiratory movements of a healthy lung or a lung containing a tumor.

[0015] The beneficial effects of this invention are: This invention uses silicone and polyurethane foam to divide the human lung into inner and outer parts, simulating the shape and internal tissues of the lung. By 3D printing an open-source lung airway model with various tracheal and bronchial airways using flexible materials such as TPU, and inserting it into the lung model during the foaming stage, it simulates the airways of a real lung, further enhancing the simulation effect. This invention can simulate human breathing by inflating and deflating the lung model using the lung airway model, and the tumor model embedded in the foam can realistically simulate the movement of a tumor during human respiration. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of the human respiratory movement simulation lung model of the present invention; Figure 2 This is a schematic diagram of the lung outer layer mold of the present invention; Figure 3 This is a schematic diagram of the lung airway model of the present invention; Figure 4 This is the preparation process of the human respiratory movement simulation lung model of the present invention.

[0017] Explanation of reference numerals in the attached figures: 1—Lung airway model; 2—Inner sponge filling layer; 3—Outer silicone wrapping layer; 4—Tumor model. Detailed Implementation

[0018] The present invention will be further described in detail below with reference to embodiments, so that those skilled in the art can implement it based on the description.

[0019] It should be understood that terms such as “having,” “comprising,” and “including” as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0020] Unless otherwise specified, the experimental methods used in the following examples are conventional methods. Unless otherwise specified, the materials and reagents used in the following examples are commercially available. For examples where specific conditions are not specified, conventional conditions or conditions recommended by the manufacturer are followed. For reagents or instruments whose manufacturers are not specified, they are all commercially available products.

[0021] Example 1 A human respiratory movement simulation lung model based on polyurethane foam sponge, referring to Figure 1 It includes an outer silicone wrapping layer 3 with a lung shape made of silicone, an inner sponge filling layer 2 made of polyurethane foam filling layer 3, a lung airway model 1 embedded in the inner sponge filling layer 2, and a tumor model 4 embedded in the inner sponge filling layer 2.

[0022] Among them, tumor model 4 was obtained by 3D printing using PLA material, and lung airway model 1 was obtained by 3D printing using flexible material, which is TPU material (thermoplastic polyurethane elastomer).

[0023] Example 2 A method for fabricating a human respiratory motion simulation lung model based on polyurethane foam sponge includes the following steps: S1. Preparation of the outer silicone coating layer 3: Mix components A and B of Guoyuan silicone G10 (Shenzhen Guoyuan Technology Co., Ltd.) at a volume ratio of 1:1, stir evenly, and defoam under vacuum. Pour the mixture into the lung outer layer mold (as shown in the diagram). Figure 2 As shown in the figure, the outer silicone coating layer 3 with the shape of a lung is obtained by solidifying at room temperature for 8 hours and clamping it out through the outer lung mold. The top of the outer silicone coating layer 3 is reserved with an infusion port that connects to the interior. S2. The lung airway model 1 (obtained by 3D printing using TPU material, as shown in the diagram) Figure 1 (As shown) After being squeezed and contracted, it is inserted into the corresponding position in the outer silicone wrapping layer 3 through the infusion port to simulate the real lung airway; S3. Preparation of the inner sponge filling layer 2: Mix the A and B components of Haibeisi polyurethane foam (Haikou Xiuying Xinying Material Sales Store) in a weight ratio of 5:2 and stir quickly and evenly. Then pour it into the outer silicone wrapping layer 3 from the injection port. Foam and form at room temperature for 5 minutes. Cut off the part that protrudes from the outer silicone wrapping layer 3, thereby filling the inner sponge filling layer 2 inside the outer silicone wrapping layer 3. S3. The tumor model 4 (3D printed using PLA material) is embedded into the corresponding position in the inner sponge filling layer 2 through the infusion port to simulate a tumor. Finally, the infusion port is sealed with silicone glue to complete the lung model preparation. This tumor model 4 can be observed in medical imaging to simulate the respiratory movements of a healthy lung or a lung containing a tumor.

[0024] The lung model provided by this invention is made of silicone and polyurethane foam. During the foaming process, 3D-printed flexible tracheas are used to recreate the tracheal and bronchial structures of the lungs. For lung tumors, various shapes of tumor models are directly prepared using PLA material 3D printing. This invention overcomes the shortcomings of traditional lung breathing models in terms of poor biomimicry. By using flexible silicone and polyurethane foam, the rigid model is transformed into a flexible model, which can simulate human breathing through inflation and deflation. The flexible tracheal and bronchial structures can effectively simulate the real lung breathing state.

[0025] Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and embodiments. They can be applied to various fields suitable for the present invention. For those skilled in the art, other modifications can be easily made. Therefore, without departing from the general concept defined by the claims and their equivalents, the present invention is not limited to the specific details.

Claims

1. A lung model based on polyurethane foamed sponge for simulating human respiratory movement, characterized in that, It includes an outer silicone wrapping layer with a lung-shaped structure made of silicone, an inner sponge filling layer made of polyurethane foam filling the outer silicone wrapping layer, and a lung airway model embedded in the inner sponge filling layer.

2. The polyurethane foam based lung model for simulating human respiratory movement according to claim 1, wherein, It also includes tumor models embedded in the internal sponge-filled layer.

3. The human respiratory movement simulation lung model based on polyurethane foam sponge according to claim 2, characterized in that, The tumor model was obtained using PLA material through 3D printing.

4. The human respiratory motion simulation lung model based on polyurethane foam sponge according to claim 1, characterized in that, The lung airway model was obtained by 3D printing using a flexible material, namely TPU (thermoplastic polyurethane elastomer).

5. A method for fabricating a human respiratory movement simulation lung model based on polyurethane foam as described in any one of claims 1-4, characterized in that, Includes the following steps: S1. Preparation of the outer silicone coating layer: Silicone is poured into the lung outer layer mold, and after solidification, an outer silicone coating layer with the shape of a lung is obtained by being clamped out through the lung outer layer mold. The top of the outer silicone coating layer is reserved with an infusion port that connects to the interior. S2. After squeezing and shrinking the lung airway model, insert it into the corresponding position in the outer silicone wrapping layer through the infusion port; S3. Preparation of the inner sponge filling layer: Pour polyurethane foam sponge into the outer silicone wrapping layer through the injection port, foam it into shape, and cut off the part that protrudes from the outer silicone wrapping layer, thereby filling the inner sponge filling layer inside the outer silicone wrapping layer.

6. The method for fabricating a human respiratory motion simulation lung model based on polyurethane foam sponge according to claim 5, characterized in that, The procedure also includes the following steps: S4, embedding the tumor model into the corresponding position in the internal sponge filling layer through the infusion port to simulate a tumor.

7. The method for fabricating a human respiratory motion simulation lung model based on polyurethane foam sponge according to claim 5, characterized in that, The solidification conditions in step S1 are: solidification at room temperature for 6-10 hours; the foaming conditions in step S3 are: foaming at room temperature for 2-10 minutes.

8. The method for fabricating a human respiratory motion simulation lung model based on polyurethane foam sponge according to claim 5, characterized in that, The two-component silicone in step S1 is Guoyuan silicone G10, and the two-component polyurethane foam in step S3 is Haibeisi polyurethane foam.

9. The method for fabricating a human respiratory motion simulation lung model based on polyurethane foam sponge according to claim 5, characterized in that, Includes the following steps: S1. Preparation of the outer silicone coating layer: Mix and stir the A and B components of Guoyuan silicone G10 in a volume ratio of 1:1 and defoam under vacuum. Pour the mixture into the lung outer layer mold and solidify at room temperature for 8 hours to obtain an outer silicone coating layer with a lung shape that is clamped out through the lung outer layer mold. The top of the outer silicone coating layer is reserved with an infusion port that connects to the interior. S2. After squeezing and shrinking the lung airway model, insert it into the corresponding position in the outer silicone wrapping layer through the infusion port; S3. Preparation of the inner sponge filling layer: Mix component A and component B of Haibeis polyurethane foam sponge in a weight ratio of 5:2 and stir evenly. Then pour it into the outer silicone wrapping layer from the injection port. Foam and form at room temperature for 5 minutes. Cut off the part that protrudes from the outer silicone wrapping layer to fill the inner sponge filling layer inside the outer silicone wrapping layer. S3. Embed the tumor model into the corresponding position in the internal sponge filling layer through the infusion port to simulate a tumor.

10. The application of a lung model as described in any one of claims 1-4 in simulating respiratory movements of a healthy lung or a lung containing a tumor.

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