Disinfectant composition

Abstract

This invention relates to a solid composition comprising 40% to 60% by weight of a peroxide donor, 20% to 35% by weight of an acetyl donor, 10% to 35% by weight of a coated organic acid, and 0.1% to 1.5% by weight of glycolic acid or lactic acid. The solid composition is suitable for use as a cleaning agent and disinfectant, particularly for hard surfaces, wherein the solid composition is dissolved in water to obtain an aqueous solution prior to use.

Description

[0001] This invention relates to a solid composition comprising an oxygen donor and an acetyl donor, suitable for use as a cleaning agent and disinfectant, particularly for inanimate surfaces, unit-dose packaging of the solid composition, and uses of the solid composition.

[0002] Disinfectant compositions based on peracetic acid (e.g., floor cleaner products) are known in the art. These compositions typically contain a peroxide donor (e.g., sodium percarbonate (SP)) and an acetyl donor (e.g., tetraacetylethylenediamine (TAED)) as precursors to generate peracetic acid (PAA) and hydrogen peroxide in situ. The disinfectant compositions are typically in powder or granule form and packaged in packaging materials (e.g., sachets).

[0003] Existing disinfectant compositions typically require the use of mixing bottles / containers to help the precursors mix and dissolve in water.

[0004] Other chemicals used for cleaning and disinfecting hard surfaces primarily use chlorine as the active ingredient. Chlorine-based products can be chlorine alone or in combination with detergents to provide cleaning and disinfecting activity.

[0005] Chlorine is currently the primary disinfectant used in hospital cleaning. However, chlorine is less effective under contaminated conditions (in the presence of organic matter). This affects its effectiveness against difficult-to-kill microorganisms, such as bacterial spores. For routine and terminal cleaning, chlorine is often used in conjunction with absorbent cotton or microfiber cloths. The non-woven fabric in the base of these materials further affects the effectiveness of chlorine.

[0006] The object of this invention is to overcome the problems of the prior art described above. Specifically, the object of this invention is to provide a composition suitable for cleaning and disinfection purposes, particularly for hard surfaces, which, when dissolved in water, provides a stable and consistent delivery of peracetic acid for the duration required in the cleaning process. Specifically, the composition should be suitable for use without the need for special mixing equipment and should be as soluble as possible to avoid solid residues after application.

[0007] In addition, compositions suitable for cleaning and disinfection purposes should be compatible with a range of hard surfaces and be able to be used in combination with different nonwoven fabrics without compromising efficacy.

[0008] The inventors were surprised to find that this objective could be achieved by a specific solid composition as outlined below.

[0009] Therefore, the present invention relates to a solid composition comprising:

[0010] 40% to 60% by weight, preferably 40% to 55% by weight, of peroxygen donor.

[0011] The acetyl donor comprises 20% to 35% by weight, preferably 20% to 28% by weight, and is preferably in powder form.

[0012] 10% to 35% by weight, preferably 20% to 30% by weight, of a coated organic acid, wherein the organic acid is preferably citric acid, malic acid, or tartaric acid, more preferably citric acid, and

[0013] Optionally, 0.1% to 1.5% by weight, preferably 0.3% to 1% by weight, of glycolic acid or lactic acid.

[0014] Optionally, the composition further comprises other organic acids, wherein the combination of the coating organic acid and other organic acids is 15% to 35% by weight.

[0015] Optionally, the amount of other organic acids is 2% to 10% by weight, preferably 3% to 9% by weight, more preferably 4% to 8% by weight, and most preferably 4% to 6% by weight.

[0016] When dissolved in water, the solid compositions of the present invention provide a stable and consistent delivery of PAA for the duration required in the cleaning process. The coating of an organic acid (preferably citric acid) supports the continuous generation of PAA over time by buffering the pH in the range of 3 to 10, preferably 6 to 8, more preferably 6.5 to 7.5.

[0017] The generated PAA provides broad-spectrum activity even in the presence of organic materials. Peracetic acid decomposes into food-safe and environmentally friendly residues (acetic acid, water, and oxygen).

[0018] The solid composition of this invention is compatible with a variety of hard surfaces. No cracking was observed during repeated application. It is possible to use it in combination with different nonwoven fabrics without compromising performance.

[0019] When the solid composition is added to water to obtain an aqueous solution, the solid composition dissolves rapidly without the need for special mixing equipment. The solid composition dissolves completely or almost completely in water or the aqueous solution. Therefore, after applying the solid composition dissolved in water or the aqueous solution, the amount of residue remaining on the surface is very low, or even non-existent. One or more surfactants optionally present in the formulation help to clean and optimize the reduction of residue / texture.

[0020] Therefore, the solid compositions of this invention overcome the following challenges: producing sustained PAA release, low residual solubility in water, and possessing the right microbial efficacy and material compatibility. Unlike chlorine-based cleaning compositions, the presence of dirt does not significantly reduce their effectiveness.

[0021] A particular advantage of the solid composition of the present invention is that a suitable PAA concentration (e.g., suitable for hospital applications) can be achieved within 15 minutes after the solid composition is added to water. Furthermore, a fairly constant PAA concentration is achieved over a long period of time.

[0022] It has been found that using coated organic acids alone is effective; however, when the solid composition is packaged in a coating (e.g., a water-soluble sachet) and the coating and composition are applied to water, the appearance of the composition in water can be unappealing. In particular, the mixture can resemble a "snowball" with floating debris. It has been found that combining other organic acids with the coated organic acid reduces this effect and makes the mixture more visually appealing.

[0023] The present invention will now be described in detail.

[0024] The weight proportions of the components in the given solid composition of the present invention are based on the total weight of the solid composition.

[0025] peroxygen donor

[0026] The solid composition of the present invention comprises 40% to 60% by weight, preferably 40% to 55% by weight, more preferably 40% to 50% by weight of a peroxide donor. The peroxide donor is preferably in powder or granular form.

[0027] Any compound known to be suitable as a peroxide donor, or a mixture thereof, may be used. The peroxide donor may be, for example, selected from sodium perborate, ammonium perborate, sodium percarbonate, potassium percarbonate, ammonium percarbonate, sodium superphosphate, ammonium persulfate, urea peroxide, perester, superoxide, dioxygenyl, ozone, hydrogen peroxide, lithium peroxide, barium peroxide, di-tert-butyl peroxide, ammonium persulfate, potassium peroxymonosulfonate, or any mixture thereof.

[0028] The peroxide donor is preferably selected from sodium perborate, sodium percarbonate, sodium superphosphate, urea peroxide, perester, superoxide, dioxygen ester, ozone, lithium peroxide, barium peroxide, di-tert-butyl peroxide, ammonium persulfate, potassium peroxymonosulfonate, or any mixture thereof.

[0029] The most preferred peroxygen donor is sodium percarbonate (SP), preferably in powder or granular form.

[0030] Acetyl donor

[0031] The solid composition of the present invention comprises 20% to 35% by weight, preferably 20% to 28% by weight, of an acetyl donor. In one embodiment, the acetyl donor is in powder or particulate form (e.g., powder form).

[0032] As an acetyl donor, any compound or mixture thereof known to be suitable as an acetyl donor may be used. For example, the acetyl donor may be selected from tetraacetylethylenediamine (TAED), TAED encapsulated in methylcellulose, acetylsalicylic acid, diacetyldioxane (DADHT), tetraacetylglycourea, acetylurea, diacetylurea, triacetylurea, pentaacetylglucose (PAG), tetraacetylglycourea (TAGU), acetylphosphate, acetimidazole, acetyl-CoA, acetic anhydride, compounds containing a hemiacetal group, acetic acid, diacetylmorphine, pyruvate, acetyl chloride, acetylcaprolactam, N'N'-diacetyl-N'N'-dimethylurea, or any mixture thereof.

[0033] The acetyl donor is preferably tetraacetylethylenediamine (TAED), such as in powder or granular form.

[0034] The weight ratio of peroxide donor to acetyl donor in the solid composition is preferably 3:1 to 1.2:1, more preferably 2.5:1 to 1.5:1. A particularly suitable weight ratio of peroxide donor to acetyl donor is about 2:1.

[0035] Coated organic acids

[0036] The solid composition of the present invention comprises 15% to 35% by weight, preferably 20% to 30% by weight, of a coated organic acid. The coated organic acid is commercially available and commonly used in the food industry.

[0037] A coated organic acid, preferably coated citric acid, is used to adjust the pH to obtain optimal PAA generation and a suitable concentration of active PAA. Compared with the use of uncoated organic acids, coated organic acids (preferably coated citric acid) support the continuous generation of PAA over time.

[0038] Organic acids are usually solid organic acids. Organic acids may contain one, two, three or more carboxyl groups, preferably two, three or more carboxyl groups.

[0039] Suitable examples of organic acids are citric acid, fatty acids, sorbic acid, malic acid, tartaric acid, glutaric acid, or any mixture thereof. Citric acid, malic acid, or tartaric acid are preferred organic acids. Citric acid is the most preferred organic acid.

[0040] Organic acids are typically in particulate form, such as powders or granules. Organic acids or organic acid particles may have a coating to form coated organic acids. Coated organic acids can be in core-shell particle form.

[0041] The coating of the organic acid is preferably selected from oils, fats, or mixtures thereof, preferably vegetable oils or fats or animal oils or fats, and more preferably vegetable oils. The coating of the organic acid is more preferably vegetable oils or animal fats, and even more preferably vegetable oils. Suitable examples of vegetable oils are palm oil, coconut oil, shea butter, rapeseed oil, and glyceryl monostearate.

[0042] Based on the total weight of the coated organic acids, the content of organic acids in the coated organic acids is preferably from 30% to 96% by weight, more preferably from 50% to 93% by weight. The balance is typically provided by the coating. In a preferred embodiment, the content of organic acids in the coated organic acids is from 55% to 90% by weight.

[0043] Coated organic acids (e.g., coated citric acid) are typically in powder or granular form. In a preferred embodiment, the coated organic acid (e.g., coated citric acid) is in granular form. The particle size of the coated organic acid (e.g., coated citric acid) is preferably less than 5000 micrometers, more preferably less than 3000 micrometers, and even more preferably less than 2500 micrometers, wherein the particle size is determined by d as measured by sieve analysis. 99 Value. The d value at 2000 micrometers was determined by sieve analysis. 99 The value means that at least 99% by weight of the sample passed through a 2000-micron sieve.

[0044] Glycolic acid (co-activator)

[0045] The solid composition of the present invention comprises 0.1% to 1.5% by weight, preferably 0.3% to 1% by weight, glycolic acid. Lactic acid can be used as an alternative acid. We note that any alternative acid (i.e., an acid present in crystalline or powder form, which acts as a co-activator in the same manner) can be used to achieve substantially the same results in substantially the same way. The use of glycolic acid or lactic acid is not strictly required.

[0046] Glycolic acid acts as a co-activator and supports the generation of PAA based on precursors (i.e., peroxy donors (e.g., SP) and acetyl donors (e.g., TAED)).

[0047] Chelating agent (optional ingredient)

[0048] The solid composition of the present invention may further contain one or more chelating agents, preferably in an amount of 0.2% to 2% by weight, more preferably in an amount of 0.3% to 1.5% by weight.

[0049] If metal ions (e.g., sodium, potassium, magnesium, calcium, and / or iron ions) are present in the water added to the solid composition to prepare an aqueous solution of the solid composition, then the addition of a chelating agent is beneficial. This is because the chelating agent can mask any metal ions that may be present in the added water, which significantly affect the reaction of the peroxide donor and the acetyl donor.

[0050] Regarding chelating agents, any chelating agent known to be suitable for masking (chelating) metal ions can be used. Examples of chelating agents are ethylenediaminetetraacetic acid (EDTA), ethylene glycol bis(2-aminoethyl ether)tetraacetic acid, diethylenetriaminepentaacetic acid (DTPA), and 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP).

[0051] In a preferred embodiment, one or more chelating agents include or are 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP).

[0052] Surfactants (optional ingredient)

[0053] The solid composition of the present invention may further contain one or more surfactants, preferably in a content of 0.5% to 8% by weight, more preferably 1% to 5% by weight.

[0054] One or more surfactants that may be present in the formulation can help clean and optimize the reduction of residue / texture.

[0055] One or more surfactants may be selected from cationic surfactants, anionic surfactants, amphoteric surfactants, or nonionic surfactants, or mixtures thereof. One or more surfactants are preferably selected from anionic surfactants and / or nonionic surfactants, with anionic surfactants being the most preferred. Examples of anionic surfactants are alkyl sulfates (e.g., ammonium lauryl sulfate and sodium lauryl sulfate (SLS)) and alkyl ether sulfates (e.g., sodium laureth sulfate (SLES) and sodium myristyl ether sulfate). Examples of nonionic surfactants are fatty alcohol ethoxylates, alkylphenol ethoxylates, and fatty acid alkoxylates.

[0056] In a preferred embodiment, one or more surfactants are anionic surfactants. Preferably, the one or more surfactants include sodium lauryl sulfate (SLS) or are sodium lauryl sulfate (SLS).

[0057] Other optional additives

[0058] The solid compositions of the present invention may contain one or more additives that are common in the art. These additives may be selected from, for example, dyes, preservatives, alkalis, essential oils, or fragrances.

[0059] Bases can be used to adjust the pH of aqueous solutions as needed. Suitable examples of bases include sodium bicarbonate, sodium hydroxide, potassium hydroxide, calcium hydroxide, and calcium carbonate.

[0060] Preferred embodiments of the solid composition

[0061] The solid composition comprises:

[0062] The peroxide donor comprises 40% to 60% by weight, preferably 40% to 55% by weight, and more preferably 40% to 50% by weight, wherein the peroxide donor is preferably sodium percarbonate (SP), such as sodium percarbonate in powder or granular form.

[0063] The acetyl donor comprises 20% to 35% by weight, preferably 20% to 28% by weight, and is preferably in powder or granular form, wherein the acetyl donor is preferably tetraacetylethylenediamine (TAED).

[0064] The coated organic acid comprises 10% to 35% by weight, preferably 20% to 30% by weight, wherein the organic acid is preferably citric acid, malic acid, or tartaric acid, more preferably citric acid, and wherein, based on the total weight of the coated organic acid, the content of organic acid in the coated organic acid is preferably 30% to 96% by weight, more preferably 50% to 93% by weight, more preferably 55% to 90% by weight, and

[0065] Optionally, 0.1% to 1.5% by weight, preferably 0.3% to 1% by weight, of glycolic acid or lactic acid.

[0066] In a preferred embodiment, the solid composition further comprises one or more chelating agents and / or one or more surfactants, preferably one or more chelating agents and one or more surfactants. The chelating agent content is preferably from 0.2% to 2% by weight, more preferably from 0.3% to 1.5% by weight. The chelating agent is preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). The surfactant content is preferably from 0.5% to 8% by weight, more preferably from 1% to 5% by weight. The surfactant is preferably anionic, more preferably sodium lauryl sulfate (SLS).

[0067] Therefore, a particularly preferred embodiment of the solid composition includes:

[0068] The peroxide donor comprises 40% to 60% by weight, preferably 40% to 55% by weight, and more preferably 40% to 50% by weight, wherein the peroxide donor is preferably sodium percarbonate (SP), such as sodium percarbonate in powder or granular form.

[0069] The acetyl donor comprises 20% to 35% by weight, preferably 20% to 28% by weight, and is preferably in powder or granular form, wherein the acetyl donor is preferably tetraacetylethylenediamine (TAED).

[0070] The coated organic acid comprises 15% to 35% by weight, preferably 20% to 30% by weight, wherein the organic acid is preferably citric acid, malic acid, or tartaric acid, more preferably citric acid, and the content of organic acid in the coated organic acid is preferably 30% to 96% by weight, more preferably 50% to 93% by weight, and more preferably 55% to 90% by weight, based on the total weight of the coated organic acid.

[0071] Glycolic acid, 0.1% to 1.5% by weight, preferably 0.3% to 1% by weight.

[0072] One or more chelating agents comprising, preferably 0.3% to 1.5% by weight, from 0.2% to 2% by weight, or more preferably 0.3% to 1.5% by weight, including 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and

[0073] One or more surfactants, preferably anionic surfactants, are used in an amount of 0.5% to 8% by weight, preferably 1% to 5% by weight, including sodium lauryl sulfate (SLS).

[0074] Uses of solid compositions in water and the formation of peracetic acid

[0075] In use, the solid composition of the present invention is added to water to obtain its aqueous solution. Stirring the aqueous solution (preferably manually, e.g., with a stirring rod or paddle) for a period of time to promote dissolution may be suitable, but this is generally unnecessary. In particular, mixing equipment with an electric mixing device is generally not required, but may certainly be used if needed.

[0076] The water added to the solid composition can be, for example, tap water, council water, or domestic water. The water may contain one or more additives.

[0077] The concentration of the solid composition in water can vary over a wide range. Suitable concentrations of the solid composition in water or aqueous solutions can be, for example, 1 g to 90 g of solid composition per liter of water, preferably 5 g to 20 g of solid composition per liter of water, more preferably 8 g to 19 g of solid composition per liter of water, and most preferably 8 g to 10 g of solid composition per liter of water.

[0078] The water added to the solid composition can be cold or warm water, for example, water with a temperature of 10°C to 55°C, preferably 30°C to 45°C.

[0079] The pH of the aqueous solution prepared by adding the solid composition to water can be 5.0 to 9.5, preferably 6.0 to 9.0, and more preferably 6.0 to 8.0.

[0080] When water is added to the solid composition, the peroxide donor is able to form hydrogen peroxide in the resulting aqueous solution. The acetyl donor can react with the generated hydrogen peroxide to produce a mixture of peracetic acid and hydrogen peroxide.

[0081] Glycolic acid acts as a co-activator, supporting the formation of PAA from peroxy and acetyl donors.

[0082] Solid composition and unit dose packaging

[0083] The solid compositions of the present invention are preferably in powder form, granule form, or a mixture of powder and granules. The powder is preferably a crystalline powder. The granules are preferably made from crystalline powder. The solid compositions can also be in compressed form, such as tablets or capsules. In compressed form, the solid compositions, typically in powder form, granule form, or a mixture of powder and granules, are compressed (e.g., in a molding machine or tablet press) into a suitable form, such as tablets or capsules.

[0084] The solid compositions of the present invention, particularly one of the above-described forms, are typically packaged in packaging materials (e.g., containers, sachets, or pods), preferably water-soluble packaging materials. In a preferred embodiment, the solid compositions of the present invention, particularly one of the above-described forms, are packaged in sachets or pods, preferably water-soluble sachets or pods. The solid compositions are most preferably packaged as water-soluble films, similar to those used for dishwasher tablets / capsules.

[0085] Water-soluble packaging materials (such as water-soluble sachets or water-soluble beads) are typically made of water-soluble films, particularly water-soluble plastic films. Water-soluble films for packaging are known in the art. Such water-soluble films can be based on plastics (e.g., polyethylene glycol, polyacrylamide, polyacrylic acid copolymers, and polyvinyl alcohol) and / or alternatively, on soluble paper, and these materials can be modified to fine-tune their solubility. Water-soluble films with different solubility properties (e.g., suitable water temperature and / or dissolution time) are available and can be selected as needed.

[0086] The advantage of using water-soluble packaging is that the packaging containing the solid composition can be easily added to water, and the solid composition does not need to be removed from the packaging before adding it to water.

[0087] In a particularly preferred embodiment, the present invention relates to a unit-dose packaging comprising a packaging material (preferably a water-soluble packaging material) and a solid composition of the invention packaged within the packaging material. The packaging material is preferably a sachet or pod, preferably a water-soluble sachet or pod.

[0088] Alternatively, single-dose packaging can be in the form of water-soluble pouches or beads with two separate compartments, allowing the solid composition to be supplied separately from the liquid composition.

[0089] The solid compositions of the present invention, their suitable forms, and suitable packaging have been described above and are hereby cited.

[0090] The advantage of the unit-dose packaging of the present invention is that users do not need to perform dosage operations. In a preferred embodiment, the packaging material of the unit-dose package is water-soluble, and users do not need to remove the composition from the packaging material; instead, they can simply place the unit-dose package directly into water.

[0091] The content of the solid composition in a unit dose package can be varied as needed. The unit dose package of the present invention may, for example, comprise 2 g to 40 g, preferably 5 g to 20 g, of the solid composition of the present invention. Suitable specifications include, for example, a unit dose package containing 15 g or 10 g of the solid composition.

[0092] Use of solid compositions or unit dose packaging

[0093] The present invention also relates to the use of the solid composition of the present invention or the unit dose package of the present invention as a cleaning agent and disinfectant, particularly for hard surfaces, wherein the solid composition is dissolved in water to obtain an aqueous solution prior to use.

[0094] The solid compositions of the present invention, their suitable forms, suitable packaging materials, and unit dose packaging have been described above and are hereby cited.

[0095] When the solid composition of the present invention is packaged in a water-soluble package or a unit dose package, the package or unit dose package can be added directly to water. If the package or unit dose package is not water-soluble, the solid composition is removed from the package or unit dose package before being added to water.

[0096] As described above, the concentration of the solid composition in water can vary over a wide range. A suitable concentration of the solid composition in water or an aqueous solution can be, for example, 1 g to 90 g of solid composition per liter of water, preferably 5 g to 20 g of solid composition per liter of water, and more preferably 8 g to 10 g of solid composition per liter of water.

[0097] The solid compositions of this invention are suitable for cleaning and disinfecting any surface, but are preferably hard surfaces. Examples of hard surfaces include walls, floors, tiles, fittings, sinks, toilets, railings, equipment, or the surfaces of upholstered furniture (e.g., hospital mattresses and chairs). An example of equipment is automated machinery. An aqueous solution containing the dissolved solid composition may also be added to equipment (e.g., automated machinery) to clean and disinfect the inner surfaces of the equipment.

[0098] According to a preferred embodiment, the solid composition of the present invention is used as a floor cleaner and disinfectant.

[0099] The invention is applicable to any location (e.g., industrial environments), and is particularly suitable for healthcare facilities, home facilities, agricultural facilities, public facilities, or facilities in the veterinary or food industries. Examples of public facilities include schools, stadiums, and offices.

[0100] A particularly preferred use of the solid composition of the present invention is for health care, cleaning, and disinfection.

[0101] The invention is further illustrated in the following non-limiting embodiments.

[0102] Example

[0103] Example 1

[0104] The preferred solid composition of the present invention is prepared in particulate form, and the formulation is shown in the table below. Sodium percarbonate (SP) is the peroxide donor. TAED (tetraacetylethylenediamine) is the acetyl donor. The chelating agent is 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). The surfactant is sodium lauryl sulfate (SLS).

[0105] The coated citric acid used was a granular powder consisting of approximately 80% by weight citric acid and approximately 20% by weight coating. The coating was made from palm oil. The coated citric acid was a granular powder with a particle size of less than 2000 micrometers, meaning that at least 99% by weight of the sample passed through a 2000-micrometer sieve. The coated citric acid used was a commercial product, such as CR300 Citric Acid 80% T3495 from TasteTech Ltd. in England and Wales.

[0106] Tables 1 and 2 list two embodiments of the composition. Each embodiment has efficacy. As described below, formulation B was the most effective formulation in the tests. Formulation A has other advantages and is an improvement on the prior art.

[0107] Formula A

[0108] Table 1

[0109] Examples 2 through 8 are based on tests conducted on formulation A. If there are minor deviations from formulation A, the precise formulation for each example is as follows.

[0110] Formula B

[0111] Table 2

[0112] For the corresponding test results, refer to Example 12 and the comparative test data. The solid composition can be packaged in sachets or beads, preferably in water-soluble sachets or beads, for example, in unit dose packaging.

[0113] Examples 2 to 12

[0114] To study various parameters of solid compositions, combinations of various formulations and ingredients have been analyzed.

[0115] After addition, the change in PAA formation in the aqueous solution over time was measured using a spectrophotometer. Active PAA was calculated based on the total amount of PAA and taking pH into account.

[0116] Example 2 – Comparison of Powder and Particulate Peroxygen Donors

[0117] Different formulations were prepared, one using sodium percarbonate granules and the other using sodium percarbonate in powder form. The results of PAA generation are as follows: Figure 1 As shown. The precise formulation used in Example 2 is described in detail in Table 3 below. The sample mass was 23.89 g, placed in 1000 mL of cold water at a temperature of 15°C to 20°C. Citric acid was omitted in this example.

[0118] Table 3

[0119] The results showed that using sodium percarbonate (SP) in powder form had no significant effect on PAA formation.

[0120] Example 3 – Amount of coated citric acid

[0121] Formula 3.1 (1.5 g coated citric acid) was prepared, with a sample mass of 25.39 g, and added to 1000 mL of cold water at a temperature of 15°C to 20°C. Improved formulas with higher amounts of coated citric acid (3 g coated citric acid (11 wt%) and 4.5 g (16 wt%)) were prepared, namely formulas 3.2 (sample mass: 26.89 g) and 3.3 (sample mass: 28.39 g), and a formula without coated citric acid was also prepared. The results of PAA generation are as follows... Figure 2 As shown. The precise formulation used in Example 3 is described in detail in Table 4 below.

[0122] The citric acid-free formulations correspond to those shown in Table 3. Other added ingredients in the formulations include... Figure 2 As shown.

[0123] Table 4

[0124] The results showed that the total amount of PAA was higher when no acidic buffer was included, which is determined by the reaction mechanism. The total amount of PAA was lower when citric acid was included. However, the active PAA was much higher when the formulation included citric acid, because the active PAA is considered the active ingredient. This will ensure effective killing of organisms within the appropriate contact time.

[0125] Example 4 – Amount of Glycolic Acid

[0126] Formula 4.1 (sample mass: 23.89 g, 0.63% glycolic acid) was prepared and compared with improved formulas having higher glycolic acid contents (1.25%, 2.47%, 3.65%, 4.81%, 5.94%, 11.22%): Formula 4.2 (sample mass: 24.04 g), Formula 4.3 (sample mass: 24.34 g), Formula 4.4 (sample mass: 24.64 g), Formula 4.5 (sample mass: 24.94 g), Formula 4.6 (sample mass: 25.24 g), and Formula 4.7 (sample mass: 26.74 g). All formulas were prepared by adding the solid composition to 1000 mL of cold water at a temperature of 15°C to 20°C. The PAA formation results are as follows. Figure 3 As shown.

[0127] The precise formulation used in Example 4 is described in detail in Table 5 below.

[0128] Table 5

[0129] Formula 4.1 is the same as shown in Table 3. For the improved formula, add glycolic acid in the percentages shown.

[0130] The results showed that 0.63% glycolic acid produced the highest total PAA concentration between 15 and 30 minutes.

[0131] Example 5 – Different Coated Organic Acids

[0132] Depending on the type of organic acid (10% citric acid, 20% citric acid, 40% citric acid, 55% citric acid, or 45% malic acid), different formulations based on Formulation 5.1 were prepared using different coating organic acids and different coating amounts. Core-shell organic acids (e.g., 10% core-shell malic acid, 20% core-shell malic acid, or 10% core-shell citric acid) were also used as coating organic acids. The results of PAA generation are as follows... Figure 4 As shown. The precise composition of formulation 5.1 used in Example 5 is described in detail in Table 6 below. The sample mass was 26.89 g and placed in 1000 mL of cold water at a temperature of 15°C to 20°C.

[0133] Table 6

[0134] For formulations that do not contain acid, the formulation is the same as shown in Table 3. Figure 4 For each of the other samples shown, the characteristics of the coating acid are listed, along with details related to the added coating acid.

[0135] The results showed that 20% coated citric acid generated the highest amount of PAA within 15 minutes. This indicates that using coated citric acid can maintain the pH, which in turn supports the continued formation of PAA.

[0136] Example 6 – Addition of different coating organic acids and bases

[0137] Depending on the type of organic acid (citric acid or malic acid), different formulations based on Formulation 6.1 were prepared using different coated organic acids and different coating amounts. In some embodiments, an alkali (sodium bicarbonate) was also added. Furthermore, samples were tested with 1000 mL of cold water at approximately 15°C to 20°C and 1000 mL of warm water at 35°C to 40°C. The results of PAA formation are as follows... Figure 5 As shown.

[0138] Table 7 shows the formulation for the sample containing 20% ​​coated citric acid. The mass of the sample was 26.90 g.

[0139] Table 7

[0140] The remaining samples were prepared based on formulation 6.1, however, as Figure 5 As shown, 20% of the coated citric acid was replaced. Furthermore, Figure 6 In this study, samples labeled as containing sodium bicarbonate were based on formulation 6.1. 2 g of sodium bicarbonate was added to these samples labeled as containing sodium bicarbonate, and the amount of acid was increased from 3.0 g to 6.0 g. The total mass of the sample was 31.90 g.

[0141] Table 8

[0142] Sodium bicarbonate was added to raise the pH, which facilitates PAA formation, followed by the addition of different coating acids to lower the pH. 20% coated citric acid without sodium bicarbonate produced the highest concentration of active PAA after 15 minutes.

[0143] Example 7 – Different coated organic acids and their addition to cold and warm water

[0144] Different formulations were prepared using different coated organic acids, depending on the type of organic acid (citric acid or malic acid) and the amount of coating. Furthermore, samples were tested using 500 mL of cold water at approximately 15°C to 20°C and 500 mL of warm water at 35°C to 40°C. The results of PAA formation are as follows... Figure 6 As shown.

[0145] Table 9 below shows the formulation used in the samples, which was determined to contain 20% coated citric acid. The remaining samples in this example are identical, except that the 20% coated citric acid in the listed samples is replaced with an alternative coated organic acid / alternative coating amount. The mass of the sample is 14.95 g.

[0146] Table 9

[0147] The results showed that using 20% ​​coated citric acid in warm water produced the most PAA after 15 and 30 minutes. This is advantageous for the product's efficacy.

[0148] Example 8 – Different amounts of solid composition and their addition to cold and warm water

[0149] Different formulations were prepared into solid compositions. Different amounts of the solid composition added to water were tested (10 g and 15 g in 500 mL of water, and 15 g and 25 g in 1000 mL of water). Furthermore, samples were tested with cold water at approximately 15°C to 20°C and warm water at approximately 35°C to 40°C. The results of PAA formation are as follows... Figure 7 and Figure 8 As shown.

[0150] Table 10 provides the formulations used for a 10 g sample. Table 11 provides the formulations used for a 15 g sample.

[0151] Table 10

[0152] Table 11

[0153] In addition, 25 g samples in the pouches were evaluated in cold water (room temperature) and 1000 mL of warm water, and compared with an improved solid composition in which the citric acid content in the pouches increased by 2%. This improved solid composition was labeled "new". PAA generation results in this comparison are as follows: Figure 9 As shown.

[0154] The original 25 g composition is shown in Table 12. The "new" formulation is shown in Table 13.

[0155] Table 12

[0156] Table 13

[0157] These data indicate that the formation of active PAA increases with increasing citric acid content in the coating.

[0158] Example 9 – Different amounts of 20% coated citric acid

[0159] Different formulations were prepared with varying amounts of 20% coated citric acid (6% in formulation 9.1, 10% in formulation 9.2, and 12% in formulation 9.3). The precise compositions of formulations 9.1, 9.2, and 9.3 used in Example 9 are described in detail in Table 14 below. The sample mass was 15.00 g.

[0160] Table 14

[0161] In one experiment, 15 g of the solid composition was added to 500 mL of water (e.g. Figure 10 (As shown). In another experiment, 10 g of the solid composition was added to 500 mL of water (as shown). Figure 11 (As shown). The results generated by PAA are as follows. Figure 10 and Figure 11 As shown.

[0162] The measurements for formulations 9.2 and 9.3 were repeated several times to examine for changes in the repeated measurements.

[0163] The experiments were repeated for each variation. These tests showed that Formulation 9.1 was less advantageous because it produced a lower amount of active PAA compared to Formulations 9.2 and 9.3. A 10% coated citric acid was chosen, and the following data are based on this addition level.

[0164] Figure 12 The results of producing PAA using 10 g of solid composition are shown.

[0165] Figure 13 The results of producing PAA using 15 g of solid composition are shown.

[0166] Example 10 – Ratio of peroxygen donor to acetyl donor

[0167] Different ratios of peroxygen donor (SP):acetyl donor (TAED) were analyzed, and it was found that a ratio of 2:1 SP:TAED produced the most PAA. The solid composition was added to 1000 mL of cold water at a temperature of 15°C to 20°C.

[0168] Example 11 – Amount of Chelating Agent

[0169] The effect of different levels of chelating agent (HEDP) on PAA formation was evaluated. Higher levels of HEDP resulted in a reduction in PAA. The solid composition was added to 1000 mL of cold water at a temperature of 15°C to 20°C.

[0170] Example 12 – Amount and Long-Term Test of Coated Citric Acid

[0171] Different formulations were prepared by increasing the weight content of coated citric acid (12.9% for formulation 12.1, 16% for formulation 12.2, 20.6% for formulation 12.3, and 25% for formulation 12.4). The precise compositions of formulations 12.1, 12.2, 12.3, and 12.4 used in Example 12 are described in detail in Table 15 below. The sample masses were 15.51 g, 16.01 g, 17.01 g, and 18.01 g, respectively.

[0172] Table 15

[0173] Based on the coating percentage, the formulation was prepared into unit-dose packages containing 15 g to 18 g of solid composition. The solid composition taken from the package was added to 1000 mL of warm water (35°C to 40°C) without stirring. PAA formation was studied up to 480 minutes after addition. Results are as follows. Figure 14 As shown.

[0174] The results showed that formulations with 20.6% and 25% wt% coated citric acid content produced relatively constant and high PAA concentrations over a long period of time.

[0175] Unit dose packages of formulation 12.4 with solid composition contents of 9 g and 18 g were prepared. The formulations are shown in the table below.

[0176] Table 16

[0177] Without stirring, three portions of 9 g and 18 g samples were each added to 1000 mL of warm water (35°C to 40°C). PAA formation was studied at 1440 minutes and 240 minutes after addition. The results are as follows. Figure 15 and Figure 16 As shown.

[0178] The results showed that both low and high concentrations of the solid composition in water produced a fairly constant and high PAA concentration over a long period of time.

[0179] Comparison of test data

[0180] Comparative tests were conducted to determine the effect of coated organic acids compared to uncoated organic acids. Different formulations were prepared by varying the amount of anhydrous tartaric acid; formulation 1 (8.74 g) had a content of 22.88%, and formulation 2 (9.00 g) had a content of 25.00%. These were then compared to a citric acid-coated formulation (formulation 3 (9.00 g) with a content of 25%). All formulations were prepared by adding the solid composition to 1000 mL of warm water at a temperature of 35°C to 40°C. Figure 17 As shown in the table below.

[0181] Table 17

[0182] The results showed that formulation 3 produced more active PAA after 15 minutes and continued to produce it throughout the experiment, especially after 24 hours.

[0183] Different formulations were prepared by varying the amount of anhydrous citric acid. Formulation 4 (8.74 g) yielded 22.88%, and Formulation 5 (9.00 g) yielded 25.00%. These were then compared with a coated citric acid formulation. Figure 18 As shown in the table below. All formulations were prepared by adding the solid composition to 1000 mL of warm water at a temperature of 35°C to 40°C.

[0184] Table 18

[0185] The results showed that formulation 3 produced significantly more active PAA after 15 minutes and continued to produce it throughout the experiment up to 180 minutes (3 hours).

[0186] This also indicates that anhydrous citric acid is not as advantageous as coated citric acid because the PAA generation level is lower during the initial 15-minute interval.

Claims

1. A solid composition comprising: 40% to 60% by weight, preferably 40% to 55% by weight, of peroxygen donor. The acetyl donor comprises 20% to 35% by weight, preferably 20% to 28% by weight, and is preferably in powder form. 10% to 35% by weight, preferably 20% to 30% by weight, of a coated organic acid, wherein the organic acid is preferably citric acid, malic acid, or tartaric acid, more preferably citric acid, and Optionally, 0.1% to 1.5% by weight, preferably 0.3% to 1% by weight, of glycolic acid or lactic acid.

2. The solid composition according to claim 1, wherein the peroxy donor is selected from sodium perborate, sodium percarbonate, sodium superphosphate, urea peroxide, perester, superoxide, dioxygen ester, ozone, hydrogen peroxide, lithium peroxide, barium peroxide, di-tert-butyl peroxide, ammonium persulfate, potassium peroxymonosulfonate, or any mixture thereof, wherein the peroxy donor is preferably sodium percarbonate.

3. The solid composition according to claim 1 or 2, wherein the acetyl donor is selected from tetraacetylethylenediamine (TAED), TAED encapsulated in methylcellulose, acetylsalicylic acid, diacetyldioxane (DADHT), tetraacetylglycourea, acetylurea, diacetylurea, triacetylurea, pentaacetylglucose (PAG), tetraacetylglycourea (TAGU), acetylphosphate, acetylimidazole, acetyl-CoA, acetic anhydride, compounds containing a hemiacetal group, acetic acid, diacetylmorphine, pyruvate, acetyl chloride, acetylcaprolactam, N'N'-diacetyl-N'N'-dimethylurea, or any mixture thereof, wherein the acetyl donor is preferably TAED.

4. The solid composition according to any one of the preceding claims, wherein the coating of the coated organic acid is selected from oils, fats or mixtures thereof, preferably vegetable oils or animal fats, more preferably vegetable oils.

5. The solid composition according to any one of the preceding claims further comprises: One or more chelating agents comprising 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and / or 0.2% to 2% by weight, preferably 0.3% to 1.5% by weight, wherein the chelating agent comprises 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or preferably 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and / or One or more surfactants, ranging from 0.5% to 8% by weight, preferably from 1% to 5% by weight, wherein the surfactant is preferably an anionic surfactant, and the surfactant preferably includes sodium lauryl sulfate (SLS) or is sodium lauryl sulfate (SLS).

6. The solid composition according to any one of the preceding claims further comprises other organic acids.

7. The solid composition according to claim 6, wherein the amount of the other organic acid is 2% to 10% by weight, preferably 3% to 9% by weight, more preferably 4% to 8% by weight, and most preferably 4% to 6% by weight.

8. The solid composition according to claim 6 or 7, wherein the combination of the coated organic acid and the other organic acid is from 15% to 35% by weight.

9. The solid composition according to any one of the preceding claims, wherein the content of organic acids in the coated organic acids is from 30% to 96% by weight, preferably from 50% to 93% by weight, based on the total weight of the coated organic acids.

10. The solid composition according to any one of the preceding claims, wherein the coated organic acid is in particulate form, wherein the particle size of the coated organic acid is preferably less than 5000 microns, more preferably less than 3000 microns, further more preferably less than 2500 microns, wherein the particle size is the d 99 value as determined by sieve analysis.

11. The solid composition according to any one of the preceding claims, wherein the solid composition is in the form of: powder, preferably crystalline powder; granules; a mixture of powder and / or granules; tablets or capsules, and / or packaged in packaging, preferably sachets or beads, more preferably water-soluble sachets or water-soluble beads, or soluble paper.

12. A unit dose package, comprising: Packaging materials, preferably water-soluble packaging materials, and The solid composition according to any one of the preceding claims is packaged in the packaging.

13. The unit dose packaging according to claim 12, wherein the packaging is a pouch or pod, preferably a water-soluble pouch or pod, and the solid composition is packaged in the pouch or pod.

14. The solid composition according to any one of claims 1 to 11 or the unit dose package according to claim 12 or claim 13 for use as a cleaning agent and disinfectant, particularly for hard surfaces, wherein the solid composition is dissolved in water to obtain an aqueous solution prior to use.

15. The use according to claim 14, wherein the hard surface is a wall, floor, tile, fittings, sink, toilet, railing, equipment, or upholstered furniture such as the surface of a hospital mattress and chair.

16. The use according to claims 14 and 15, wherein the solid composition is used as a floor cleaner and disinfectant.

17. The use according to any one of claims 14 to 16, for use in health care facilities, home facilities, agricultural facilities, public facilities, or facilities in the veterinary or food industries.

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