Sample testing device and extraction member

Abstract

A sample detection device and an extraction component are disclosed. The sample detection device includes a reagent storage component, a reagent dispensing component, a sample dispensing component, an extraction component, an amplification component, a detection component, a first liquid transfer component, a scheduling component, and a controller. The reagent dispensing component dispenses a first reagent into a first cavity of the extraction component and dispenses a second reagent into a second cavity of the extraction component. The sample dispensing component dispenses samples into the extraction component. The extraction component extracts nucleic acids from the liquid in the extraction component. The first liquid transfer component transfers the liquid in the extraction component to an amplification tube. The amplification component and the detection component amplify and detect the liquid in the amplification tube. The scheduling component schedules the extraction component. After the first liquid transfer component transfers at least a portion of the liquid in the first cavity after nucleic acid extraction to the amplification tube, the first liquid transfer component also transfers the second reagent in the second cavity to the amplification tube.

Description

Sample detection device and extraction parts

[0001] This application claims priority to the Chinese patent application filed with the China Patent Office on December 29, 2023, with application number 202311871110.0. The entire contents of the above application are incorporated by reference into this application. Technical Field

[0002] The present invention relates to the field of medical devices, and in particular to a sample detection device and an extraction component. Background Art

[0003] The nucleic acid extraction process in existing sample detection devices involves the reagent dispensing assembly injecting the reaction reagent into a reaction cup, followed by the sample dispensing assembly injecting the sample and reaction reagent into the reaction cup for a reaction. The reaction cup is then transferred to the extraction station, where the reagent dispensing assembly injects the reagents required for nucleic acid extraction into the reaction cup. Finally, the extracted liquid containing nucleic acids is transferred to the amplification tube. Since the level of contamination in the nucleic acid extraction process increases after the sample dispensing assembly injects the sample into the reaction cup, it can easily contaminate the reagent dispensing assembly and reagents in the extraction station, leading to inaccurate test results. Summary of the Invention

[0004] In view of this, the present invention provides a sample detection device and an extraction element.

[0005] The sample detection device proposed in the first aspect of the present invention includes a reagent storage component, a reagent dispensing component, a sample dispensing component, an extraction component, an amplification component, a detection component, a first liquid transfer component, a scheduling component and a controller. The sample detection device is also formed with a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component is used to store at least a first reagent container and a second reagent container, the first reagent container is used to store a first reagent, and the second reagent container is used to store a second reagent. The reagent dispensing component is used to dispense the first reagent stored in the first reagent container and the second reagent stored in the second reagent container to the extraction component located at the reagent dispensing station. The sample dispensing component is used to dispense the first reagent stored in the first reagent container and the second reagent stored in the second reagent container to the extraction component located at the reagent dispensing station. The extraction part of the sample dispensing station dispenses samples, the extraction component is used to extract nucleic acid from the liquid in the extraction part located at the extraction station, the first liquid transfer component is used to transfer the liquid in the extraction part located at the liquid transfer station to the amplification tube located at the liquid transfer station, the amplification component is used to amplify the liquid in the amplification tube located at the amplification station, the detection component is used to detect the liquid in the amplification tube located at the detection station, the scheduling component is used to schedule the extraction part between the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station, the scheduling component is also used to schedule the amplification tube between the liquid transfer station, the amplification station and the detection station, and the controller is configured as follows:

[0006] Controlling the reagent dispensing assembly to dispense the first reagent in the first reagent container in the reagent storage assembly into the first cavity of the extraction member located at the reagent dispensing station, and to dispense the second reagent in the second reagent container in the reagent storage assembly into the second cavity of the extraction member located at the reagent dispensing station;

[0007] Controlling the dispatching component to dispatch the extraction member from the reagent dispensing station to the sample dispensing station, and controlling the sample dispensing component to dispense the sample into the first cavity;

[0008] Controlling the dispatching component to dispatch the extraction unit located at the sample dispensing station and having dispensed the sample to the extraction station, and controlling the extraction component to extract nucleic acid from the liquid in the first cavity;

[0009] Controlling the scheduling component to transfer the extraction piece after nucleic acid extraction is completed at the extraction station to the liquid transfer station, controlling the first liquid transfer component to transfer at least part of the liquid in the first chamber after nucleic acid extraction is completed to the amplification tube located at the liquid transfer station, and then controlling the first liquid transfer component to transfer the second reagent in the second chamber to the amplification tube located at the liquid transfer station;

[0010] Control the scheduling component to schedule the amplification tube to the amplification station, control the amplification component to perform amplification processing on the liquid in the amplification tube, control the scheduling component to schedule the amplification tube after the amplification processing at the amplification station to the detection station, and control the detection component to detect the liquid in the amplification tube located at the detection station.

[0011] The sample detection device proposed in the second aspect of the present invention includes a reagent storage component, a reagent dispensing component, a sample dispensing component, an extraction component, an amplification component, a detection component, a first liquid transfer component, a scheduling component and a controller. The sample detection device is also formed with a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component is used to store at least a first reagent container and a second reagent container, the first reagent container is used to store a first reagent, and the second reagent container is used to store a second reagent. The reagent dispensing component is used to dispense the first reagent stored in the first reagent container and the second reagent stored in the second reagent container to the extraction component located at the reagent dispensing station. The sample dispensing component is used to dispense the first reagent stored in the first reagent container and the second reagent stored in the second reagent container to the extraction component located at the reagent dispensing station. The extraction part of the sample dispensing station dispenses samples, the extraction component is used to extract nucleic acids from the liquid in the extraction part located at the extraction station, the first liquid transfer component is used to transfer the liquid in the extraction part located at the liquid transfer station to the amplification tube located at the liquid transfer station, the amplification component is used to amplify the liquid in the amplification tube located at the amplification station, the detection component is used to detect the liquid in the amplification tube located at the detection station, the scheduling component is used to schedule the extraction part between the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station, the scheduling component is also used to schedule the amplification tube between the liquid transfer station, the amplification station and the detection station, and the controller is configured to:

[0012] Controlling the reagent dispensing assembly to dispense the first reagent in the first reagent container in the reagent storage assembly into the first cavity of the extraction member located at the reagent dispensing station, and to dispense the second reagent in the second reagent container in the reagent storage assembly into the second cavity of the extraction member located at the reagent dispensing station;

[0013] Controlling the dispatching component to dispatch the extraction member from the reagent dispensing station to the sample dispensing station, and controlling the sample dispensing component to dispense the sample into the first cavity;

[0014] Controlling the dispatching component to dispatch the extraction component located at the sample dispensing station and having dispensed the sample to the extraction station, and controlling the extraction component to extract nucleic acid from the liquid in the first cavity, wherein the second reagent is transferred from the second cavity to the first cavity of the extraction component during the nucleic acid extraction process;

[0015] Controlling the scheduling component to transfer the extraction piece after nucleic acid extraction is completed at the extraction station to the liquid transfer station, and controlling the first liquid transfer component to transfer at least part of the liquid in the first cavity after nucleic acid extraction is completed to the amplification tube located at the liquid transfer station;

[0016] Control the scheduling component to schedule the amplification tube to the amplification station, control the amplification component to perform amplification processing on the liquid in the amplification tube, control the scheduling component to schedule the amplification tube after the amplification processing at the amplification station to the detection station, and control the detection component to detect the liquid in the amplification tube located at the detection station.

[0017] The third aspect of the present invention provides an extraction component, which is applied to a molecular diagnostic device. At least a reagent dispensing component and a sample dispensing component are provided in the housing of the molecular diagnostic device. The extraction component includes an open first cavity and a second cavity. The first cavity is used to accommodate a first reagent injected by the reagent dispensing component and a sample injected by the sample dispensing component. The second cavity is used to accommodate a second reagent injected by the reagent dispensing component.

[0018] The extraction element provided in the fourth aspect of the present invention comprises:

[0019] a strip, comprising a first side and a second side opposite to the first side in a thickness direction of the strip, the strip having at least two openings arranged along a length direction of the strip and penetrating the strip in a thickness direction;

[0020] At least two tubes are provided on the second side of the strip, and the at least two tubes are in one-to-one communication with the at least two openings;

[0021] The strip-shaped member includes a first end face and a second end face opposite to the first end face in the length direction, the first end face is recessed toward the second end face to form a first positioning groove, and the second end face is recessed toward the first end face to form a second positioning groove.

[0022] It can be seen from the above technical solutions that the sample detection device proposed in the first aspect of the present invention, by being arranged at a reagent dispensing station to transfer the liquid after the subsequent nucleic acid extraction in the first cavity to the amplification tube, the second reagent required in the process is injected into the second cavity of the extraction part. There is no need to add a mechanism for injecting the second reagent into the amplification tube at the liquid transfer station, which can simplify the device structure and reduce the size of the device. Moreover, since the pollution level of the station downstream of the sample dispensing station is relatively high, in this embodiment, by arranging the reagent dispensing assembly for dispensing the second reagent upstream of the sample dispensing station, the risk of contamination of the reagent dispensing assembly can be effectively reduced, thereby improving the accuracy of sample detection. In addition, compared with the first liquid transfer assembly drawing the second reagent from the additional mechanism for injecting the second reagent into the amplification tube and injecting the drawn second reagent into the amplification tube, the first liquid transfer assembly in this embodiment draws the second reagent from the second cavity of the extraction part and then transfers it to the amplification tube. The path taken is shorter and takes less time, thereby improving the analysis efficiency of the sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained from these drawings without any creative work.

[0024] FIG1 is a schematic structural diagram of a sample detection device according to an embodiment of the present invention;

[0025] FIG2 is a schematic diagram of the structure of an extraction component proposed in one embodiment of the present invention;

[0026] FIG3 is a schematic structural diagram of an extraction member according to an embodiment of the present invention;

[0027] FIG4 is a schematic structural diagram of a sample detection method proposed in one embodiment of the present invention;

[0028] FIG5 is a schematic structural diagram of a sample detection method proposed in another embodiment of the present invention;

[0029] FIG6 is a schematic structural diagram of a sample detection method proposed in another embodiment of the present invention;

[0030] FIG7 is a schematic diagram of the horizontal distribution of a sample analyzer within a space of a first layer according to an embodiment of the present invention;

[0031] 8 is a schematic diagram of the distribution of the first consumables supply device, the second consumables supply device and the reagent storage device provided in Example 1 of the present invention;

[0032] FIG9 is a cross-sectional schematic diagram of an extraction member according to an embodiment of the present invention;

[0033] FIG10 is a partial enlarged schematic diagram of point A in FIG9;

[0034] FIG11 is a partial enlarged schematic diagram of point B in FIG9;

[0035] FIG12 is a partial enlarged schematic diagram of point C in FIG9;

[0036] FIG13 is a partial cross-sectional schematic diagram of an extraction member according to an embodiment of the present invention;

[0037] FIG14 is a schematic diagram of the three-dimensional structure of an extraction member according to an embodiment of the present invention;

[0038] FIG15 is a schematic top view of the structure of an extraction member according to an embodiment of the present invention;

[0039] FIG16 is a schematic diagram of a plurality of extraction members stacked together according to an embodiment of the present invention;

[0040] FIG17 is a schematic structural diagram of an extraction member according to an embodiment of the present invention;

[0041] FIG18 is a schematic structural diagram of an extraction member according to an embodiment of the present invention;

[0042] FIG19 is a schematic structural diagram of two extraction members cross-arranged according to an embodiment of the present invention. DETAILED DESCRIPTION

[0043] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0044] As shown in Figures 1 to 4, an embodiment of the present invention proposes a sample detection device 1000, which includes a reagent storage component 201, a reagent dispensing component 202, a sample dispensing component 203, an extraction component 204, an amplification component 205, a detection component 206, a first liquid transfer component 207, a scheduling component 208 and a controller 209. The sample detection device 1000 is also formed with a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component 201 is at least used to store a first reagent container and a second reagent container. The first reagent container is used to store a first reagent, and the second reagent container is used to store a second reagent. The reagent dispensing component 202 is used to dispense the first reagent stored in the first reagent container and the second reagent container into the extraction component 100 located at the reagent dispensing station. The second reagent container stores a second reagent, the sample dispensing component 203 is used to dispense samples from the extraction unit 100 located at the sample dispensing station, the extraction component 204 is used to extract nucleic acids from the liquid in the extraction unit 100 located at the extraction station, the first liquid transfer component 207 is used to transfer the liquid in the extraction unit 100 located at the liquid transfer station to the amplification tube located at the liquid transfer station, the amplification component 205 is used to amplify the liquid in the amplification tube located at the amplification station, the detection component 206 is used to detect the liquid in the amplification tube located at the detection station, the scheduling component 208 is used to schedule the extraction unit 100 between the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station, the scheduling component 208 is also used to schedule the amplification tube between the liquid transfer station, the amplification station and the detection station, and the controller 209 is configured as follows:

[0045] In step S11, the reagent dispensing component 202 is controlled to dispense the first reagent in the first reagent container in the reagent storage component 201 into the first cavity 101 of the extraction part 100 located at the reagent dispensing station, and the second reagent in the second reagent container in the reagent storage component 201 is dispensed into the second cavity 102 of the extraction part 100 located at the reagent dispensing station.

[0046] In one embodiment, the reagent storage assembly 201 includes a reagent tray, which is a disc-shaped structure having multiple positions for holding reagent containers. The reagent storage assembly 201 can rotate and drive the reagent containers it carries to rotate, so as to rotate the reagent containers to a specific position, such as a position for the reagent to be drawn by the reagent dispensing assembly 202. In another embodiment, the reagent storage assembly 201 is not a disc-shaped structure and is not rotatable. For example, it is a fixed rectangular structure, and the reagent storage assembly 201 is provided with multiple reagent container positions, and the reagent containers are placed in the reagent container positions.

[0047] In one embodiment, the reagent dispensing component 202 may include a reagent needle, which is driven by a two-dimensional or three-dimensional driving mechanism to perform two-dimensional or three-dimensional movement in space, so that the reagent needle can move to absorb the reagent in the reagent container carried by the reagent storage component 201.

[0048] In step S12 , the dispatching component 208 is controlled to dispatch the extraction unit 100 from the reagent dispensing station to the sample dispensing station, and the sample dispensing component 203 is controlled to dispense the sample into the first cavity 101 .

[0049] In one embodiment, the sample dispensing component 203 may include a sample needle, which is driven by a two-dimensional or three-dimensional driving mechanism to perform two-dimensional or three-dimensional movement in space, so that the sample needle can move to absorb the sample on the sample aspiration position, and move to the sample dispensing position to dispense the absorbed sample into the first cavity 101.

[0050] In step S13 , the control scheduling component 208 schedules the extraction unit 100 located at the sample dispensing station and dispensed with the sample to the extraction station, and controls the extraction component 204 to extract nucleic acid from the liquid in the first cavity 101 .

[0051] In step S14, the control scheduling component 208 transfers the extraction unit 100 that has completed the nucleic acid extraction at the extraction station to the liquid transfer station, controls the first liquid transfer component 207 to transfer at least part of the liquid in the first cavity 101 after the nucleic acid extraction is completed to the amplification tube located at the liquid transfer station, and then controls the first liquid transfer component 207 to transfer the second reagent in the second cavity 102 to the amplification tube located at the liquid transfer station.

[0052] In one embodiment, the scheduling component 208 includes a first transport rack, which is provided with an extraction part position and an amplification tube position. The extraction part position is used to place the extraction part 100. A magnet is provided at the extraction part position. The magnet is used to perform a magnetic suction operation on the extraction part 100 located at the extraction part position to gather the magnetic beads in the extraction part 100 on the bottom wall or side wall of the first cavity 101 of the extraction part 100. The amplification tube position is used to place the amplification tube. After the nucleic acid extraction is completed at the extraction station, the scheduling component 208 transfers the extraction part 100 to the extraction part position on the first transport rack, and then the first transport rack moves to the liquid transfer station. Then the first liquid transfer component 207 transfers at least part of the liquid after the nucleic acid extraction in the first cavity 101 is completed to the amplification tube of the liquid transfer station, and then controls the first liquid transfer component 207 to transfer the second reagent in the second cavity 102 to the amplification tube of the liquid transfer station.

[0053] In step S15, the control scheduling component 208 schedules the amplification tube to the amplification station, controls the amplification component 205 to perform amplification processing on the liquid in the amplification tube, controls the scheduling component 208 to schedule the amplification tube after the amplification processing at the amplification station to the detection station, and controls the detection component 206 to detect the liquid in the amplification tube at the detection station.

[0054] Among them, the methods that can be used for amplification treatment include polymerase chain reaction (PCR), loop mediated isothermal amplification (LAMP), isothermal and chimeric primer initiated amplification (ICAN), nuclear acid sequence-based amplification (NASBA), strand displacement amplification (SDA), ligase chain reaction (LCR), and rolling circle amplification (RCA).

[0055] In one embodiment, the detection assembly 206 includes a light measuring component that measures light on the incubated reaction solution to obtain sample reaction data. For example, the light measuring component measures the luminescence intensity of the reaction solution to be measured and calculates the concentration of the component to be measured in the sample using a calibration curve.

[0056] In this embodiment, by setting up a reagent dispensing station to transfer the liquid in the subsequent first cavity 101 after the nucleic acid extraction is completed to the amplification tube, the second reagent required is injected into the second cavity 102 of the extraction part 100. There is no need to add a mechanism for injecting the second reagent into the amplification tube at the liquid transfer station, which can simplify the device structure and reduce the size of the device. Moreover, since the station downstream of the sample dispensing station has a relatively high degree of contamination, in this embodiment, by setting the reagent dispensing component 202 for dispensing the second reagent upstream of the sample dispensing station, the risk of contamination of the reagent dispensing component 202 can be effectively reduced, thereby improving the accuracy of sample detection. In addition, compared to the first liquid transfer component 207 drawing the second reagent from the additional mechanism for injecting the second reagent into the amplification tube and injecting the drawn second reagent into the amplification tube, the first liquid transfer component 207 in this embodiment draws the second reagent from the second cavity 102 of the extraction part 100 and then transfers it to the amplification tube. The path taken is shorter and takes less time, thereby improving the analysis efficiency of the sample.

[0057] As shown in Figures 1 and 3, in one embodiment, the sample testing device 1000 further includes a first loading assembly 210. The first loading assembly 210 is used to load the first pipetting head 21 within the third chamber 103 of the extraction unit 100 onto the first liquid transfer assembly 207, so that the first liquid transfer assembly 207 can aspirate liquid through the first pipetting head 21. In one embodiment, the first loading assembly 210 is used to drive the first liquid transfer assembly 207 to move in a vertical direction and at least one horizontal direction. The first loading assembly 210 first drives the first liquid transfer assembly 207 to move horizontally above the third chamber 103 of the extraction unit 100, then drives the first liquid transfer assembly 207 to descend vertically, inserting the end of the first liquid transfer assembly 207 into the open end of the first pipetting head 21 to complete the loading of the first pipetting head 21. In another embodiment, the first loading assembly 210 is used to drive the first liquid transfer assembly 207 to move in a vertical direction and two mutually perpendicular horizontal directions. In this embodiment, by arranging the first liquid transfer component 207 so that the pipette head used for liquid transfer is directly loaded from the third cavity 103 of the extraction component 100, the sample detection device 1000 does not need to additionally provide a loading mechanism for the pipette head and a scheduling component 208, which can simplify the device structure and reduce the size of the device.

[0058] In one embodiment, the process of controlling the first liquid transfer component 207 to transfer at least a portion of the liquid after nucleic acid extraction in the first cavity 101 is completed to the amplification tube of the liquid transfer station is as follows: control the first loading component 210 to load the first pipette head 21 in the third cavity 103 of the extraction part 100 to the end of the first liquid transfer component 207, and then control the first liquid transfer component 207 to absorb at least a portion of the liquid after nucleic acid extraction in the first cavity 101 is completed, and transfer the absorbed liquid to the amplification tube of the liquid transfer station.

[0059] As shown in Figures 1 to 3, in one embodiment, the reagent storage component 201 is also used to store a third reagent container, which is used to store an elution reagent. Before the extraction unit 100 is dispatched to the sample dispensing station, the controller 209 further controls the reagent dispensing component 202 to dispense the elution reagent in the third reagent container in the reagent storage component 201 into the fourth cavity 104 of the extraction unit 100, where the first reagent includes a magnetic bead reagent; the extraction component 204 includes a carrier 2041, an incubation unit 2042, a first magnetic member 2043, a first pipetting member 2044 and a second pipetting member 2045. The carrier 2041 is provided with an aspiration station and an elution station. The carrier 2041 is used to carry the extraction unit 100. The first magnetic member 2043 is used to perform a magnetic suction operation on the extraction unit 100 located at the aspiration station to gather the magnetic beads in the extraction unit 100 on the bottom wall or side wall of the first cavity 101 of the extraction unit 100. The control unit 204 is used to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction unit 100 located at the liquid aspiration station, and the second pipetting unit 2045 is used to inject the elution reagent in the fourth cavity 104 of the extraction unit 100 into the first cavity 101 of the extraction unit 100 located at the elution station. The control unit 204 extracts nucleic acid from the liquid in the first cavity 101, including: controlling the scheduling unit 208 to schedule the extraction unit 100 located at the sample dispensing station to the incubation station. The incubation component 2042 is incubated; the control scheduling component 208 dispatches the incubated extraction component 100 to the liquid aspiration station, and controls the first pipetting component 2044 to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction component 100; the control scheduling component 208 dispatches the extraction component after the liquid aspiration operation to the elution station, and controls the second pipetting component 2045 to inject the elution reagent in the fourth cavity 104 of the extraction component 100 into the first cavity 101 of the extraction component 100.

[0060] That is, in this embodiment, after the sample and the first reagent are incubated, the first pipette 2044 sucks out the waste liquid in the first cavity 101 , and then the second pipette 2045 sucks the elution reagent and injects the sucked elution reagent into the first cavity 101 .

[0061] As shown in Figures 1 to 3, in one embodiment, the sample testing device 1000 further includes a second loading assembly 211. The second loading assembly 211 is used to load the first pipetting head 21 within the third cavity 103 of the extraction unit 100 onto the second pipetting unit 2045, allowing the second pipetting unit 2045 to aspirate liquid through the first pipetting head 21. In one embodiment, the second loading assembly 211 is used to drive the second pipetting unit 2045 to move in a vertical direction and at least one horizontal direction. The second loading assembly 211 first drives the second pipetting unit 2045 horizontally to above the third cavity 103 of the extraction unit 100, then drives the second pipetting unit 2045 vertically downward, inserting the end of the second pipetting unit 2045 into the open end of the first pipetting head 21 to complete the loading of the first pipetting head 21. In another embodiment, the second loading assembly 211 is used to drive the second pipetting unit 2045 to move in a vertical direction and two mutually perpendicular horizontal directions. In this embodiment, by arranging the second pipetting member 2045 to load the pipette head used for liquid transfer directly from the third cavity 103 of the extraction member 100, the sample detection device 1000 does not need to additionally provide a loading mechanism for the pipette head and a scheduling component 208, which can simplify the device structure and reduce the size of the device.

[0062] In one embodiment, the process of controlling the second pipetting component 2045 to inject the elution reagent in the fourth cavity 104 of the extraction component 100 into the first cavity 101 of the extraction component 100 located at the elution station is as follows: control the second loading assembly 211 to load the first pipetting head 21 in the third cavity 103 of the extraction component 100 to the end of the second pipetting component 2045, and then control the second pipetting component 2045 to extract the elution reagent from the fourth cavity 104 of the extraction component 100, and inject the absorbed elution reagent into the first cavity 101 of the extraction component 100 located at the elution station.

[0063] As shown in Figures 1 and 3, in one embodiment, the sample detection device 1000 further includes a cleaning liquid providing component 212, the extraction component 204 further includes a second magnetic component 2046 and a third liquid transfer component 2047, and the carrier 2041 is further provided with a cleaning station. The cleaning liquid providing component 212 is used to inject cleaning liquid into the first cavity 101 of the extraction component located at the cleaning station, and the second magnetic component 2046 is used to perform a magnetic operation on the extraction component 100 located at the cleaning station to gather the magnetic beads in the extraction component 100 on the bottom wall or side wall of the first cavity 101 of the extraction component 100. The third liquid transfer component 2047 is used to collect the magnetic beads in the extraction component 100 on the bottom wall or side wall of the first cavity 101 of the extraction component 100. 047 is used to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction part 100 located at the cleaning station, and the controller 209 is also configured to: control the scheduling component 208 to schedule the extraction part located at the liquid aspiration station and after completing the liquid aspiration operation to the cleaning station; control the cleaning liquid providing component 212 to inject cleaning liquid into the extraction part located at the cleaning station, and control the third pipetting part 2047 to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction part 100 after completing the magnetic suction operation to absorb the cleaning liquid; control the scheduling component 208 to schedule the extraction part 100 after completing the liquid aspiration operation to the elution station.

[0064] That is, in this embodiment, after the first pipette 2044 sucks out the waste liquid in the first cavity 101 and before the second pipette 2045 sucks the elution reagent and injects the sucked elution reagent into the first cavity 101, the cleaning liquid is also injected and sucked out of the first cavity 101.

[0065] As shown in Figures 1 and 3, in one embodiment, the sample detection device 1000 further includes a second loading assembly 211, which is used to load the second pipetting head 22 in the fifth cavity 105 of the extraction component 100 onto the first pipetting component 2044 or the third pipetting component 2047, so that the first pipetting component 2044 or the third pipetting component 2047 absorbs liquid through the second pipetting head 22.

[0066] In one embodiment, the process of the first pipetting member 2044 performing the pipetting operation on the first cavity 101 of the extraction member 100 in the pipetting station is as follows: control the second loading assembly 211 to load the second pipetting head 22 in the fifth cavity 105 of the extraction member 100 to the end of the first pipetting member 2044, and then control the first pipetting member 2044 to absorb the liquid in the first cavity 101 of the extraction member 100 at the pipetting station.

[0067] In one embodiment, the process of controlling the third pipetting component 2047 to absorb the cleaning liquid is as follows: control the second loading assembly 211 to load the second pipetting head 22 in the fifth cavity 105 of the extraction component 100 to the end of the third pipetting component 2047, and then control the third pipetting component 2047 to absorb the cleaning liquid in the first cavity 101 of the extraction component of the cleaning station.

[0068] In one embodiment, the first pipetting element 2044 and the third pipetting element 2047 are the same liquid transfer component.

[0069] As shown in Figures 1 to 3, in one embodiment, the controller 209 is further configured to control the first pipetting member 2044 and the third pipetting member 2047 to transfer the absorbed liquid to the sixth cavity 106 of the extraction member 100. In this embodiment, the first pipetting member 2044 and the third pipetting member 2047 have a shorter path when discharging waste liquid, thereby shortening the discharge time of the waste liquid and improving the analysis efficiency of the sample. Of course, the present invention is not limited to the above embodiment. For example, in another embodiment, the sample detection device 1000 is further provided with a waste liquid collection device, and the first pipetting member 2044 and the third pipetting member 2047 can also transfer the absorbed liquid to the waste liquid collection device.

[0070] In one embodiment, the sample detection device 1000 further includes a capping assembly for grabbing the cap of the amplification tube and attaching the captured cap to the open end of the amplification tube. After the first liquid transfer assembly 207 transfers the second reagent in the second chamber 102 into the amplification tube, the controller 209 is further configured to control the capping assembly to attach the cap to the open end of the amplification tube located at the liquid transfer station. In this embodiment, by attaching the cap to the open end of the amplification tube, the large-scale volatilization of the liquid containing nucleic acid in the amplification tube during the amplification process can be effectively reduced, thereby reducing cross-contamination.

[0071] In one embodiment, the second reagent is used to seal the liquid containing nucleic acids in the amplification tube. In this embodiment, the second reagent can reduce the large-scale volatilization of the liquid containing nucleic acids in the amplification tube during the amplification process, thereby reducing cross contamination. The second reagent can be, but is not limited to, a silicone oil reagent.

[0072] In one embodiment, the first reagent includes at least two types, and the control of the reagent dispensing assembly 202 to dispense the first reagent from the first reagent container in the reagent storage assembly 201 into the first cavity 101 of the extraction unit 100 includes: controlling the reagent dispensing assembly 202 to sequentially draw at least two first reagents from the first reagent container, and then controlling the reagent dispensing assembly 202 to inject the at least two drawn first reagents into the first cavity 101 at once. The term "sequentially drawing" refers to drawing one of the at least two first reagents before drawing the other of the at least two first reagents, and does not limit the order in which the first reagents are drawn. In this embodiment, by injecting the at least two first reagents into the first cavity 101 of the extraction unit 100 in a multiple-draw-one-row manner, the first reagent dispensing time can be effectively shortened, thereby shortening the sample analysis time and improving analysis efficiency. Of course, in other embodiments, the reagent dispensing assembly 202 can also use a single-draw-one-row method to inject the at least two first reagents into the first cavity 101 of the extraction unit 100, and the specific method can be determined based on actual design requirements.

[0073] In one embodiment, the first reagent includes a lysate, an IC (inner control) reagent, a magnetic bead reagent and a proteinase K. The specific process of the control reagent dispensing component 202 dispensing the first reagent in the first reagent container in the reagent storage component 201 into the first cavity 101 in the extraction part 100 is as follows: the control reagent dispensing component 202 sequentially absorbs the lysate, IC reagent, magnetic bead reagent and proteinase K from the first reagent container, and then the control reagent dispensing component 202 injects the absorbed lysate, IC reagent, magnetic bead reagent and proteinase K into the first cavity 101 at one time.

[0074] In one embodiment, the sample detection device 1000 further includes a housing and a partition. The housing has a receiving chamber. The partition is disposed within the receiving chamber to separate the receiving chamber into a reagent chamber and a sample chamber. The reagent dispensing assembly 202 is located in the reagent chamber, and the sample dispensing assembly 203 is located in the sample chamber. The partition has an opening for the dispatching assembly 208 to dispatch the extraction unit 100 only from the reagent dispensing station to the sample dispensing station. In this embodiment, the reagent area and the sample area can be separated to prevent contamination of the reagent area by the sample area.

[0075] As shown in Figures 1, 5 and 6, in one embodiment, the sample detection device 1000 also includes a first consumable supply device 213 and a second consumable supply device 214. The first consumable supply device 213 is at least used to provide the extraction part 100. The second consumable supply device 214 is at least used to provide the amplification tube. The sample dispensing component 203 is used to draw at least part of the sample from the sample container and dispense it into the extraction part 100 provided by the first consumable supply device 213. The extraction component 204 is used to extract nucleic acid from the liquid containing at least the sample in the extraction part 100 to obtain a nucleic acid extract. In this embodiment, the extraction part 100 is provided by the first consumable supply device 213, and the amplification tube is provided by the second consumable supply device 214. In this way, the continuous detection requirements of batch samples can be met, which helps to avoid the situation where the sample detection efficiency is affected by the lack of the amplification extraction part 100 and the reaction container.

[0076] As shown in Figures 1 and 5, in one embodiment, the sample detection device 1000 further includes a sample storage assembly 215, which is used to store at least a sample container containing a sample. The sample container can be manually loaded into the sample storage device by a user or automatically loaded by an automatic sample loading device. The sample dispensing assembly 203 is used to draw at least a portion of the sample from the sample container provided by the sample storage assembly 215 and dispense it into the extraction unit 100 provided by the first consumable supply device 213.

[0077] As shown in FIG5 , in one embodiment, the scheduling component 208 includes a first consumable material conveying component 2081 and a second consumable material conveying component 2082. The first consumable material conveying component 2081 is used to carry at least the extraction member 100 for linear motion along the first horizontal direction P1, and the second consumable material conveying component 2082 is used to carry at least the amplification tube for linear motion along the first horizontal direction P1. The first consumable material conveying component 2081 and the second consumable material conveying component 2082 are arranged side by side along the second horizontal direction P2, and the second horizontal direction P2 is approximately perpendicular to the first horizontal direction P1. The first consumable material conveying component 2081 and the second consumable material conveying component 2082 are two consumable material conveying components that can independently convey consumables, that is, the first consumable material conveying component 2081 and the second consumable material conveying component 2082 can operate in parallel. The first consumable material conveying assembly 2081 and the second consumable material conveying assembly 2082 are arranged side by side along the second horizontal direction P2. Specifically, the first consumable material conveying assembly 2081 and the second consumable material conveying assembly 2082 are distributed along the second horizontal direction P2, and the first consumable material conveying assembly 2081 and the second consumable material conveying assembly 2082 are roughly parallel. The first consumable material conveying assembly 2081 and the second consumable material conveying assembly 2082 can be in contact with each other, or there can be a gap between them, as long as it does not affect the consumable material conveying of the two. The second horizontal direction P2 is roughly perpendicular to the first horizontal direction P1, including: the angle formed by the intersection of the second horizontal direction P2 and the first horizontal direction P1 is 90°, and the angle formed by the intersection of the second horizontal direction P2 and the first horizontal direction P1 is slightly larger or slightly smaller than 90° within a certain range. The first consumables conveying assembly 2081 and the second consumables conveying assembly 2082 are substantially parallel, including: the first consumables conveying assembly 2081 and the second consumables conveying assembly 2082 are parallel to each other, and there is an inclination angle within a certain small range between the first consumables conveying assembly 2081 and the second consumables conveying assembly 2082. In this embodiment, the scheduling assembly 208 is configured to include the first consumables conveying assembly 2081 and the second consumables conveying assembly 2082. This allows at least some of the extraction units 100 and amplification tubes to be scheduled in parallel, which helps improve scheduling efficiency.

[0078] As shown in Figure 5, in one embodiment, the first consumable material conveying assembly 2081 has a first side and a second side arranged on opposite sides along the second horizontal direction P2, the second consumable material conveying assembly 2082 has a first side and a second side arranged on opposite sides along the second horizontal direction P2, the second side of the first consumable material conveying assembly 2081 is adjacent to the first side of the second consumable material conveying assembly 2082, at least a portion of at least one of the sample storage assembly 215, the extraction assembly 204 and the amplification assembly 205 is located on the first side of the first consumable material conveying assembly 2081, and at least a portion of at least another of the sample storage assembly 215, the extraction assembly 204 and the amplification assembly 205 is located on the second side of the second consumable material conveying assembly 2082. In this embodiment, the consumables conveying components of the extraction part 100 and the amplification tube are arranged in the middle area, and at least part of at least two of the sample storage component 215, the extraction component 204 and the amplification component 205 are arranged on the opposite side of the middle area, which is equivalent to setting two consumables conveying lines in the middle and distributing the functional modules on the opposite sides of the two consumables conveying lines. In this way, the two consumables conveying lines can simultaneously meet the consumables scheduling needs of the functional modules on both sides without the need to set up a separate consumables conveying component for each functional module, which is beneficial to simplifying the consumables scheduling network of the sample detection device 1000, and further beneficial to improving the scheduling efficiency of nucleic acid extraction containers and amplification tubes between various functional modules, and beneficial to reducing the volume and cost of the sample detection device 1000.

[0079] As shown in FIG5 , in one embodiment, sample storage assembly 215 is located on a first side of first consumable transport assembly 2081, and at least a portion of at least one of extraction assembly 204 and amplification assembly 205 is located on a second side of second consumable transport assembly 2082. That is, first consumable transport assembly 2081 is located between sample storage assembly 215 and second consumable transport assembly 2082 along second horizontal direction P2. In this embodiment, first consumable transport assembly 2081 is located closer to sample storage assembly 215 than second consumable transport assembly 2082; and second consumable transport assembly 2082 is located closer to at least one of extraction assembly 204 and amplification assembly 205 than first consumable transport assembly 2081. Since the sample stored in the sample storage assembly 215 is primarily intended for dispensing into the extraction unit 100, the first consumable transport assembly 2081, which is used to dispatch the extraction unit 100, is positioned closer to the sample storage assembly 215. This helps reduce the movement of the sample dispensing assembly 203 when dispensing the sample, thereby improving the detection efficiency of the sample detection device 1000 and reducing the risk of sample contamination. Of course, in specific applications, the relative positional relationship between the sample storage assembly 215, the extraction unit 204, the amplification unit 205, the first consumable transport assembly 2081, and the second consumable transport assembly 2082 is not limited to this. For example, as an alternative embodiment, the relative positional relationship between the sample storage assembly 215, the extraction unit 204, the amplification unit 205, the first consumable transport assembly 2081, and the second consumable transport assembly 2082 may also be such that the sample storage assembly 215 is located on the second side of the second consumable transport assembly 2082, and at least a portion of at least one of the extraction unit 204 and the amplification unit 205 is located on the first side of the first consumable transport assembly 2081.

[0080] As shown in FIG5 , in one embodiment, at least portions of the sample storage component 215, the extraction component 204, and the amplification component 205 are distributed along the first horizontal direction P1 on the same side of the scheduling component 208. That is, at least portions of the sample storage component 215, the extraction component 204, and the amplification component 205 are distributed side by side along the first horizontal direction P1 and on the same side of the scheduling component 208. In this embodiment, the sample storage component 215, the extraction component 204, and the amplification component 205 are all distributed around the scheduling component 208. Since two of the sample storage component 215, the extraction component 204, and the amplification component 205 are distributed along the first horizontal direction P1, and at least part of the two are distributed along the second horizontal direction P2 on the opposite side of the scheduling component 208, that is, two of the sample storage component 215, the extraction component 204, and the amplification component 205 are distributed along the first horizontal direction P1 and two along the second horizontal direction P2, rather than being arranged in a straight line along one horizontal direction, this layout scheme can effectively reduce the size of the sample detection device 1000 in a single horizontal direction, thereby helping to improve the space utilization of the molecular laboratory.

[0081] As shown in FIG5 , in one embodiment, the sample storage assembly 215 is located on a first side of the first consumable material transport assembly 2081, and the extraction assembly 204 and the amplification assembly 205 are both at least partially located on a second side of the second consumable material transport assembly 2082, with the extraction assembly 204 and the amplification assembly 205 arranged side by side along a first horizontal direction P1. In this embodiment, the sample storage assembly 215 is disposed on one of the two opposing sides of the dispatch assembly 208, and at least a portion of the extraction assembly 204 and at least a portion of the amplification assembly 205 are disposed on the other side. This not only reduces the size of the sample detection device 1000 in a single horizontal direction, but also shortens the travel distance for the nucleic acid extract extracted by the extraction assembly 204 to be dispatched to the amplification assembly 205, thereby improving the detection efficiency of the sample detection device 1000 and reducing contamination of the nucleic acid extraction system and the amplification reaction system by the sample area. Of course, in specific applications, the distribution of the sample storage component 215, the extraction component 204, the amplification component 205, the first consumable material conveying component 2081 and the second consumable material conveying component 2082 is not limited to this. For example, as an alternative embodiment, the sample storage component 215 and the extraction component 204 are at least partially located on the first side of the first consumable material conveying component 2081, and the amplification component 205 is at least partially located on the second side of the second consumable material conveying component 2082, and the sample storage component 215 and the extraction component 204 are arranged side by side along the first horizontal direction P1; or, as another alternative embodiment, the sample storage component 215 and the amplification component 205 are at least partially located on the first side of the first consumable material conveying component 2081, and the extraction component 204 is at least partially located on the second side of the second consumable material conveying component 2082, and the sample storage component 215 and the amplification component 205 are arranged side by side along the first horizontal direction P1.

[0082] As shown in FIG5 , in one embodiment, the reagent storage assembly 201 and the sample storage assembly 215 are arranged side by side along a first horizontal direction P1 and are at least partially located on the same side of the scheduling assembly 208. In this embodiment, the reagent storage assembly 201 and the sample storage assembly 215 are arranged on the same side of the scheduling assembly 208, which facilitates an operator or a robot to load reagents and samples on the same side of the sample testing device 1000.

[0083] As shown in FIG5 , in one embodiment, the reagent storage assembly 201 and the sample storage assembly 215 are arranged side by side along a first horizontal direction P1 on a first side of the first consumable material transport assembly 2081. In this embodiment, the first consumable material transport assembly 2081 for dispatching the extraction unit 100 is disposed adjacent to the reagent storage assembly 201 and the sample storage assembly 215. The distance between the reagent storage assembly 201 and the sample storage assembly 215 and the first consumable material transport assembly 2081 is shorter than the distance between the reagent storage assembly 201 and the sample storage assembly 215 and the second consumable material transport assembly 2082. This helps to reduce the travel distance of the sample dispensing assembly 203 when dispensing the sample from the sample storage assembly 215 to the extraction unit 100, and helps to reduce the travel distance of the reagent dispensing device 102 when dispensing the reagent from the reagent storage assembly 201 to the extraction unit 100, thereby improving the sample and reagent distribution efficiency.

[0084] As shown in Figure 5, in one embodiment, the reagent storage component 201 includes a first reagent storage component 2011 and a second reagent storage component 2012, and the reagent dispensing component 202 includes a first reagent dispensing component and a second reagent dispensing component; wherein the first reagent storage component 2011 is used to store a first type of reagent, the first reagent dispensing component is used to draw the first type of reagent from the first reagent storage component 2011 and dispense it into the extraction component 100, and the extraction component 204 is used to extract nucleic acids from the liquid in the extraction component 100 that at least contains the sample and the first type of reagent to obtain a nucleic acid extract; the second reagent storage component 2012 is used to store a second type of reagent, the second reagent dispensing component is used to draw the second type of reagent from the second reagent storage component 2012 and dispense it into an amplification tube, and the amplification component 205 is used to amplify the liquid in the amplification tube that at least contains the nucleic acid extract and the second type of reagent to obtain a test liquid. The first type of reagent is mainly used for nucleic acid extraction, and the first type of reagent is also called an extraction reagent. The second type of reagent is mainly used for amplification reaction, and the second type of reagent is also called an amplification reagent. In this embodiment, the extraction reagent is dispensed into the extraction unit 100 by aspiration, and the amplification reagent is dispensed into the amplification tube by aspiration. Of course, in specific applications, as an alternative embodiment, one of the extraction reagent and the amplification reagent may be pre-stored in a container, for example, the extraction reagent may be pre-stored in the extraction unit 100, or the amplification reagent may be pre-stored in the amplification tube.

[0085] As shown in FIG5 , in one embodiment, at least a portion of the second consumables supply device 214, the first reagent storage assembly 2011, the second reagent storage assembly 2012, and the sample storage assembly 215 are arranged side by side along a first horizontal direction P1. The first consumables transport assembly 2081 extends past the sides of the second consumables supply device 214, the first reagent storage assembly 2011, the second reagent storage assembly 2012, and the sample storage assembly 215. In this embodiment, the consumables area, reagent area, and sample area are located on the same side of the sample testing device 1000. This not only helps reduce the reagent and sample dispensing distance, but also facilitates operators or operating robots to load amplification tubes, first-type reagents, second-type reagents, and samples on the same side of the sample testing device 1000. Of course, in specific applications, the distribution of the second consumable supply device 214, the first reagent storage component 2011, the second reagent storage component 2012, and the sample storage component 215 is not limited to this. As an alternative implementation scheme, at least one of the second consumable supply device 214, the first reagent storage component 2011, and the second reagent storage component 2012 can also be arranged on the second side of the second consumable conveying component 2082. For example, the second consumable supply device 214 and / or the second reagent storage component 2012 can be arranged on the second side of the second consumable conveying component 2082.

[0086] As shown in FIG5 , in one embodiment, at least a portion of the second consumables supply device 214, the first reagent storage assembly 2011, the second reagent storage assembly 2012, and the sample storage assembly 215 are sequentially arranged side by side along a first horizontal direction P1, i.e., the first consumables transport assembly 2081 extends from the side of the second consumables supply device 214, sequentially passing through the side of the first reagent storage assembly 2011, the side of the second reagent storage assembly 2012, and the side of the sample storage assembly 215. In this embodiment, the reagent area is disposed between the consumables area and the sample area. On the one hand, it is convenient to perform reagent distribution first and then sample distribution, so that the consumables are first transported to the reagent area for reagent distribution without passing through the sample area. After sample distribution, the consumables no longer pass through the reagent area, which helps prevent contamination of the reagent area by the sample.

[0087] Of course, in specific applications, the side-by-side arrangement of the second consumable supply device 214, the first reagent storage component 2011, the second reagent storage component 2012, and the sample storage component 215 is not limited to the above-mentioned scheme. For example, the following alternative implementation scheme may also be adopted: at least part of the second consumable supply device 214, the second reagent storage component 2012, the first reagent storage component 2011, and the sample storage component 215 are sequentially arranged side by side along the first horizontal direction P1; or, at least part of the second consumable supply device 214, the first reagent storage component 2011, the sample storage component 215, and the second reagent storage component 2012 are sequentially arranged side by side along the first horizontal direction P1; or, at least part of the second consumable supply device 214, the second reagent storage component 2012, the sample storage component 215, and the first reagent storage component 2011 are sequentially arranged side by side along the first horizontal direction P1; The second consumables supply device 214, the sample storage component 215, the second reagent storage component 2012, and the first reagent storage component 2011 are sequentially arranged side by side along the first horizontal direction P1; or, at least part of the second consumables supply device 214, the sample storage component 215, the second reagent storage component 2012, and the first reagent storage component 2011 are sequentially arranged side by side along the first horizontal direction P1; or, the first reagent storage component 2011, the second reagent storage component 2012, the second consumables supply device 214 and the sample storage component 215 are sequentially arranged side by side along the first horizontal direction P1; or, the second reagent storage component 2012, the first reagent storage component 2011, The second consumable supply device 214 and the sample storage component 215 are distributed side by side in sequence along the first horizontal direction P1; alternatively, the first reagent storage component 2011, the second consumable supply device 214, the second reagent storage component 2012 and the sample storage component 215 are distributed side by side in sequence along the first horizontal direction P1; alternatively, the second reagent storage component 2012, the second consumable supply device 214, the first reagent storage component 2011 and the sample storage component 215 are distributed side by side in sequence along the second horizontal direction P2 and along the first horizontal direction P1.

[0088] As shown in FIG. 5 , in one embodiment, the sample storage component 215 , the second reagent storage component 2012 , the first reagent storage component 2011 , the second consumables supply device 214 , the amplification component 205 and the extraction component 204 are distributed around three sides of the scheduling component 208 .

[0089] As shown in FIG5 , in one embodiment, the sample storage assembly 215, the second reagent storage assembly 2012, the first reagent storage assembly 2011, the second consumables supply device 214, the amplification assembly 205, and the extraction assembly 204 are arranged in a U-shape around three sides of the dispatch assembly 208. Specifically, the sample storage assembly 215, the second reagent storage assembly 2012, the first reagent storage assembly 2011, and the second consumables supply device 214 are arranged side by side along a first horizontal direction P1, the amplification assembly 205 and the extraction assembly 204 are arranged along the first horizontal direction P1, the sample storage assembly 215, the second reagent storage assembly 2012, and the first reagent storage assembly 2011 are located on a first side of the first consumables transport assembly 2081, the extraction assembly 204 and a portion of the amplification assembly 205 are located on a second side of the second consumables transport assembly 2082, the second consumables supply device 214 extends from one side of the first reagent storage assembly 2011 toward the amplification assembly 205, and a portion of the amplification assembly 205 extends toward the second consumables supply device 214.

[0090] As shown in FIG6 , in one embodiment, the first consumables supply device 213 is located below the second consumables supply device 214, and the first consumables supply device 213 extends from below the second consumables supply device 214 to below the reagent storage assembly 201. In this embodiment, the longitudinal space of the sample testing device 1000, i.e., the upper and lower spaces, is fully utilized, and the extraction unit 100 and modules such as amplification tubes and reagents that occupy a large space are designed vertically, thereby further reducing the horizontal space occupied by the sample testing device 1000. In addition, because the first consumables supply device 213, the second consumables supply device 214, the reagent storage assembly 201, and the sample storage assembly 215 are located on the same side of the sample testing device 1000, it is convenient for an operator or an operating robot to perform the extraction unit 100, amplification tubes, first type reagents, second type reagents, and sample loading operations on the same side of the sample testing device 1000.

[0091] As shown in FIG. 6 , in one embodiment, the first consumables supply device 213 extends from directly below the second consumables supply device 214 to directly below the first reagent storage assembly 2011 and directly below the second reagent storage assembly 2012 .

[0092] In one embodiment, the sample testing device 1000 has an upper space and a lower space. The second consumables supply device 214, the first reagent storage assembly 2011, the second reagent storage assembly 2012, the first consumables conveying assembly 2081, the second consumables conveying assembly 2082, the extraction assembly 204, and the amplification assembly 205 are located in the upper space, and the first consumables supply device 213 is located in the lower space. In this embodiment, the extraction component 100 is stored in the lower layer, while the other consumables are stored and the workstations are located in the upper layer. This helps shorten the consumables scheduling path and makes the robot structure simpler, thereby reducing the horizontal area occupied by the entire sample testing device 1000 and increasing the supply efficiency of consumables.

[0093] As shown in Figures 1 to 3 and Figure 7, an embodiment of the present invention further proposes a sample detection device 1000, which includes a reagent storage component 201, a reagent dispensing component 202, a sample dispensing component 203, an extraction component 204, an amplification component 205, a detection component 206, a first liquid transfer component 207, a scheduling component 208 and a controller 209. The sample detection device 1000 is also formed with a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component 201 is used to store at least a first reagent container and a second reagent container. The first reagent container is used to store a first reagent, and the second reagent container is used to store a second reagent. The reagent dispensing component 202 is used to dispense the first reagent stored in the first reagent container into the extraction component 100 located at the reagent dispensing station. and a second reagent stored in a second reagent container, the sample dispensing component 203 is used to dispense samples from the extraction unit 100 located at the sample dispensing station, the extraction component 204 is used to extract nucleic acids from the liquid in the extraction unit 100 located at the extraction station, the first liquid transfer component 207 is used to transfer the liquid in the extraction unit 100 located at the liquid transfer station to the amplification tube located at the liquid transfer station, the amplification component 205 is used to amplify the liquid in the amplification tube located at the amplification station, the detection component 206 is used to detect the liquid in the amplification tube located at the detection station, the scheduling component 208 is used to schedule the extraction unit 101 between the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station, the scheduling component 208 is also used to schedule the amplification tube between the liquid transfer station, the amplification station and the detection station, and the controller 209 is configured as follows:

[0094] Step S21, controlling the reagent dispensing assembly 202 to dispense the first reagent in the first reagent container in the reagent storage assembly 201 into the first cavity 101 of the extraction unit 100 located at the reagent dispensing station, and to dispense the second reagent in the second reagent container in the reagent storage assembly 201 into the second cavity 102 of the extraction unit 100 located at the reagent dispensing station;

[0095] Step S22 , controlling the scheduling component 208 to schedule the extraction unit 100 from the reagent dispensing station to the sample dispensing station, and controlling the sample dispensing component 203 to dispense the sample into the first cavity 101 ;

[0096] Step S23: Control the dispatching component 208 to dispatch the extraction unit 100, which is located at the sample dispensing station and has dispensed the sample, to the extraction station, and control the extraction component 204 to extract nucleic acid from the liquid in the first cavity 101. During the nucleic acid extraction process, the second reagent is transferred from the second cavity 102 to the first cavity 101 of the extraction unit.

[0097] Step S24: Control the scheduling component 208 to transfer the extraction unit 100 after nucleic acid extraction at the extraction station to the liquid transfer station, and control the first liquid transfer component 207 to transfer at least part of the liquid in the first cavity 101 after nucleic acid extraction to the amplification tube located at the liquid transfer station.

[0098] In step S25, the control scheduling component 208 schedules the amplification tube to the amplification station, controls the amplification component 205 to perform amplification processing on the liquid in the amplification tube, controls the scheduling component 208 to schedule the amplification tube after the amplification processing at the amplification station to the detection station, and controls the detection component 206 to detect the liquid in the amplification tube at the detection station.

[0099] The sample detection device 1000 proposed in this embodiment injects the second reagent required in the nucleic acid extraction process into the second cavity 102 of the extraction part 100 by being set at the reagent dispensing station. There is no need to set up a mechanism for injecting the second reagent into the extraction part 100 at the extraction station, which can simplify the device structure and reduce the size of the device. Moreover, since the pollution level of the station downstream of the sample dispensing station is relatively high, in this embodiment, by setting the reagent dispensing component 202 for dispensing the second reagent upstream of the sample dispensing station, the risk of contamination of the reagent dispensing component 202 can be effectively reduced, thereby improving the accuracy of sample detection. In addition, compared with the first liquid transfer component 207 drawing the second reagent from the additional mechanism for injecting the second reagent into the extraction part 100 and injecting the drawn second reagent into the first cavity 101 of the extraction part 100, the path taken by the second reagent from the second cavity 102 of the extraction part 100 to the first cavity 101 of the extraction part 100 in this embodiment is shorter and takes less time, thereby improving the analysis efficiency of the sample.

[0100] In one embodiment, the sample detection device 1000 further includes a first loading assembly 210 , which is used to load the first pipetting head 21 in the third cavity 103 of the extraction component 100 into the first liquid transfer assembly 207 , so that the first liquid transfer assembly 207 absorbs liquid through the first pipetting head 21 .

[0101] In one embodiment, the second reagent is an elution reagent, and the first reagent includes a magnetic bead reagent; the extraction component 204 also includes a carrier 2041, an incubation component 2042, a first magnetic component 2043, a first pipetting component 2044 and a second pipetting component 2045. The carrier 2041 is provided with an aspiration station and an elution station. The carrier 2041 is used to carry the extraction component 100, and the first magnetic component 2043 is used to perform a magnetic operation on the extraction component 100 located at the aspiration station to gather the magnetic beads in the extraction component 100 on the bottom wall or side wall of the first cavity 101 of the extraction component 100. The first pipetting component 2044 is used to perform a pipetting operation on the liquid in the first cavity 101 of the extraction component 100 located at the aspiration station, and the second pipetting component 2045 is used to perform a pipetting operation on the second cavity 101 of the extraction component 100. 102 is injected into the first cavity 101 of the extraction part 100 located at the elution station, and the extraction component 204 is controlled to extract nucleic acid from the liquid in the first cavity 101, including: controlling the scheduling component 208 to schedule the extraction part 100 located at the sample dispensing station to the incubation part 2042 for incubation; controlling the scheduling component 208 to schedule the incubated extraction part 100 to the aspiration station, and controlling the first pipetting part 2044 to perform aspiration operation on the liquid in the first cavity 101 of the extraction part 100; controlling the scheduling component 208 to schedule the extraction part 100 after the aspiration operation to the elution station, and controlling the second pipetting part 2045 to inject the elution reagent in the second cavity 102 of the extraction part 100 into the first cavity 101 of the extraction part 100 at the elution station.

[0102] In one embodiment, the sample detection device 1000 further includes a second loading assembly 211 for loading the first pipetting head 21 in the third cavity 103 of the extraction component 100 onto the second pipetting component 2045 so that the second pipetting component 2045 aspirates liquid through the first pipetting head 21 .

[0103] In one embodiment, the sample detection device 1000 further includes a cleaning liquid providing component 212, the extraction component 204 further includes a second magnetic component 2046 and a third liquid transfer component 2047. The second magnetic component 2046 and the third liquid transfer component 2047 are provided. The carrier 2041 is further provided with a cleaning station. The cleaning liquid providing component 212 is used to inject cleaning liquid into the first cavity 101 of the extraction component located at the cleaning station. The second magnetic component 2046 is used to perform a magnetic operation on the extraction component 100 located at the cleaning station to gather the magnetic beads in the extraction component 100 on the bottom wall or side wall of the first cavity 101 of the extraction component 100. The third pipetting component 2047 is used to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction component 100 located at the liquid aspiration station. The controller 209 is also configured to: control the scheduling component 208 to schedule the extraction component located at the liquid aspiration station and after completing the liquid aspiration operation to the cleaning station; control the cleaning liquid providing component 212 to inject cleaning liquid into the extraction component located at the cleaning station, and control the third pipetting component 2047 to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction component 100 after completing the magnetic suction operation; control the scheduling component 208 to schedule the extraction component 100 after completing the liquid aspiration operation to the elution station.

[0104] In one embodiment, the sample detection device 1000 further includes a second loading assembly 211, which is used to load the second pipetting head 22 in the fourth cavity 104 of the extraction component 100 onto the first pipetting component 2044 or the third pipetting component 2047, so that the first pipetting component 2044 or the third pipetting component 2047 absorbs liquid through the second pipetting head 22.

[0105] In one embodiment, the controller 209 is further configured to control the first pipetting component 2044 and the third pipetting component 2047 to transfer the sucked liquid to the sixth cavity 106 of the extraction component 100 .

[0106] In one embodiment, the first reagent includes at least two types, and the controlling reagent dispensing component 202 dispenses the first reagent in the first reagent container in the reagent storage component 201 into the first cavity 101 in the extraction member 100, including: controlling the reagent dispensing component 202 to sequentially absorb at least two first reagents from the first reagent container, and then controlling the reagent dispensing component 202 to inject the absorbed at least two first reagents into the first cavity 101 at one time.

[0107] In one embodiment, the sample detection device 1000 also includes a cover assembly for grabbing the tube cap of the amplification tube and covering the grabbed tube cap on the open end of the amplification tube. After the first liquid transfer assembly 207 transfers the second reagent in the second cavity 102 into the amplification tube, the controller 209 is also configured to: control the cover assembly to cover the tube cap on the open end of the amplification tube located at the liquid transfer station.

[0108] The beneficial effects of various embodiments of the sample detection device 1000 proposed in this embodiment and other undescribed implementation methods can refer to the above embodiments and will not be described in detail here.

[0109] As shown in Figures 1 to 3 and Figure 8, an embodiment of the present invention further proposes a sample detection device 1000, which includes a reagent storage component 201, a reagent dispensing component 202, a sample dispensing component 203, an extraction component 204, an amplification component 205, a detection component 206, a first liquid transfer component 207, a cover component, a scheduling component 208 and a controller 209. The sample detection device 1000 is also formed with a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component 201 is used to store at least a first reagent container and a second reagent container. The first reagent container is used to store a first reagent, and the second reagent container is used to store a second reagent. The reagent dispensing component 202 is used to dispense the first reagent stored in the first reagent container and the second reagent stored in the second reagent container into the extraction component 100 located at the reagent dispensing station. The sample dispensing component 203 is used to dispense samples from the extraction unit 100 located at the sample dispensing station, the extraction component 204 is used to extract nucleic acids from the liquid in the extraction unit 100 located at the extraction station, the first liquid transfer component 207 is used to transfer the liquid in the extraction unit 100 located at the liquid transfer station to the amplification tube located at the liquid transfer station; the cover closing component is used to grab the tube cover of the amplification tube and cover the grabbed tube cover to the open end of the amplification tube; the amplification component 205 is used to amplify the liquid in the amplification tube located at the amplification station; the detection component 206 is used to detect the liquid in the amplification tube located at the detection station, the scheduling component 208 is used to schedule the extraction unit 100 between the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station, and the scheduling component 208 is also used to schedule the amplification tube between the liquid transfer station, the amplification station and the detection station. The controller 209 is configured as follows:

[0110] Step S31 , controlling the reagent dispensing component 202 to dispense the first reagent in the first reagent container in the reagent storage component 201 into the first cavity 101 of the extraction component 100 of the reagent dispensing station;

[0111] Step S32 , controlling the scheduling component 208 to schedule the extraction unit 100 from the reagent dispensing station to the sample dispensing station, and controlling the sample dispensing component 203 to dispense the sample into the first cavity 101 ;

[0112] Step S33 , controlling the scheduling component 208 to schedule the extraction unit 100 located at the sample dispensing station and having dispensed the sample to the extraction station, and controlling the extraction component 204 to extract nucleic acid from the liquid in the first cavity 101 ;

[0113] Step S34: The control scheduling component 208 transfers the extraction unit 100 after nucleic acid extraction at the extraction station to the liquid transfer station, and controls the liquid transfer component to transfer at least part of the liquid in the first cavity 101 after nucleic acid extraction to the amplification tube located at the liquid transfer station.

[0114] Step S35, controlling the cap closing assembly to close the tube cap to the open end of the amplification tube located at the liquid transfer station;

[0115] Step S36, control the scheduling component 208 to schedule the amplification tube to the amplification station, control the amplification component 205 to perform amplification processing on the liquid in the amplification tube, control the scheduling component 208 to schedule the amplification tube after the amplification processing at the amplification station to the detection station, and control the detection component 206 to detect the liquid in the amplification tube located at the detection station.

[0116] The sample detection device 1000 proposed in an embodiment of the present invention is configured such that after the liquid transfer component transfers at least a portion of the liquid after nucleic acid extraction in the first cavity 101 to the amplification tube at the liquid transfer station, the closing cover component closes the tube cover to the open end of the amplification tube at the liquid transfer station. This can effectively reduce the large-scale volatilization of the liquid containing nucleic acid in the amplification tube during the amplification process, thereby reducing cross contamination.

[0117] In one embodiment, the sample detection device 1000 further includes a first loading assembly 210 , which is used to load the first pipetting head 21 in the third cavity 103 of the extraction component 100 into the first liquid transfer assembly 207 , so that the first liquid transfer assembly 207 absorbs liquid through the first pipetting head 21 .

[0118] In one embodiment, the reagent storage component 201 is also used to store a third reagent container, which is used to store an elution reagent. Before the extraction component 100 is dispatched to the sample dispensing station, the controller 209 also controls the reagent dispensing component 202 to dispense the elution reagent in the third reagent container in the reagent storage component 201 into the fourth cavity 104 of the extraction component 100, where the first reagent includes a magnetic bead reagent; the extraction component 204 includes a carrier 2041, an incubation component 2042, a first magnetic component 2043, a first pipetting component 2044 and a second pipetting component 2045. The carrier 2041 is provided with an aspiration station and an elution station. The carrier 2041 is used to carry the extraction component 100. The first magnetic component 2043 is used to perform a magnetic suction operation on the extraction component 100 located at the aspiration station to gather the magnetic beads in the extraction component 100 on the bottom wall or side wall of the first cavity 101 of the extraction component 100. The first pipetting component 2044 is used to The second pipetting component 2045 is used to perform a pipetting operation on the liquid in the first cavity 101 of the extraction component 100 located at the pipetting station, and the elution reagent in the fourth cavity 104 of the extraction component 100 is injected into the first cavity 101 of the extraction component 100 located at the elution station. The control extraction component 204 performs nucleic acid extraction on the liquid in the first cavity 101, including: controlling the scheduling component 208 to schedule the extraction component 100 located at the sample dispensing station to the incubation component 2042 for incubation; controlling the scheduling component 208 to schedule the incubated extraction component 100 to the pipetting station, and controlling the first pipetting component 2044 to perform a pipetting operation on the liquid in the first cavity 101 of the extraction component 100; controlling the scheduling component 208 to schedule the extraction component after the pipetting operation to the elution station, and controlling the second pipetting component 2045 to inject the elution reagent in the fourth cavity 104 of the extraction component 100 into the first cavity 101 of the extraction component 100.

[0119] In one embodiment, the sample detection device 1000 further includes a second loading assembly 211 for loading the first pipetting head 21 in the third cavity 103 of the extraction component 100 onto the second pipetting component 2045 so that the second pipetting component 2045 aspirates liquid through the first pipetting head 21 .

[0120] In one embodiment, the sample detection device 1000 further includes a cleaning liquid providing component 212, the extraction component 204 further includes a second magnetic component 2046 and a third liquid transfer component 2047. The second magnetic component 2046 and the third liquid transfer component 2047 are provided. The carrier 2041 is further provided with a cleaning station. The cleaning liquid providing component 212 is used to inject cleaning liquid into the first cavity 101 of the extraction component located at the cleaning station. The second magnetic component 2046 is used to perform a magnetic operation on the extraction component 100 located at the cleaning station to gather the magnetic beads in the extraction component 100 on the bottom wall or side of the first cavity 101 of the extraction component 100. The third pipetting component 2047 is used to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction component 100 located at the cleaning station, and the controller 209 is further configured to: control the scheduling component 208 to schedule the extraction component located at the liquid aspiration station and after completing the liquid aspiration operation to the cleaning station; control the cleaning liquid providing component 212 to inject cleaning liquid into the extraction component located at the cleaning station, and control the third pipetting component 2047 to perform a liquid aspiration operation on the liquid in the first cavity 101 of the extraction component 100 after completing the magnetic suction operation; control the scheduling component 208 to schedule the extraction component after completing the liquid aspiration operation to the elution station.

[0121] In one embodiment, the sample detection device further includes a second loading assembly 211, which is used to load the second pipetting head 22 in the fifth cavity 105 of the extraction component 100 onto the first pipetting component 2044 or the third pipetting component 2047, so that the first pipetting component 2044 or the third pipetting component 2047 absorbs liquid through the second pipetting head 22.

[0122] In one embodiment, the controller 209 is further configured to control the first pipetting component 2044 and the third pipetting component 2047 to transfer the sucked liquid to the sixth cavity 106 of the extraction component 100 .

[0123] In one embodiment, the first reagent includes at least two types, and the controlling reagent dispensing component 202 dispenses the first reagent in the first reagent container in the reagent storage component 201 into the first cavity 101 in the extraction member 100, including: controlling the reagent dispensing component 202 to sequentially absorb at least two first reagents from the first reagent container, and then controlling the reagent dispensing component 202 to inject the absorbed at least two first reagents into the first cavity 101 at one time.

[0124] The beneficial effects of various embodiments of the sample detection device 1000 proposed in this embodiment and other undescribed implementation methods can refer to the above embodiments and will not be described in detail here.

[0125] As shown in Figure 3, an embodiment of the present invention further proposes an extraction member 100, which is applied to a molecular diagnostic device. At least a reagent dispensing component and a sample dispensing component are provided in the shell of the molecular diagnostic device. The extraction member 100 includes an open first cavity 101 and a second cavity 102. The first cavity 101 is used to accommodate a first reagent injected by the reagent dispensing component and a sample injected by the sample dispensing component, and the second cavity 102 is used to accommodate a second reagent injected by the reagent dispensing component.

[0126] The extraction piece 100 proposed in this embodiment is provided with an open first cavity 101 and a second cavity 102, and the first reagent and the second reagent are subsequently injected into the first cavity 101 and the second cavity 102 by the molecular diagnostic device during the molecular diagnosis process. Compared with the existing extraction piece 100, the first cavity 101 is pre-filled with the first reagent and the second cavity 102 is pre-filled with the second reagent, and then the opening of the first cavity 101 and the opening of the second cavity 102 are sealed by means of a sealing film. In the subsequent molecular diagnosis process, the extraction piece 100 proposed in this embodiment does not need to consider the problem of sealing film puncture, which can simplify the process.

[0127] As shown in Figures 3 and 9, in one embodiment, the extraction unit 100 further includes an open third cavity 103 and a fourth cavity 104. The third cavity 103 is used to accommodate the first pipetting head 21, and the fourth cavity 104 is used to accommodate the second pipetting head 22. The volume of the second pipetting head 22 is larger than that of the first pipetting head 21. In one embodiment, the extraction unit 100 further includes an open fifth cavity 105, which is used to accommodate a third reagent injected by the molecular diagnostic device. In one embodiment, the extraction unit 100 further includes an open sixth cavity 106, which is used to accommodate waste liquid. The extraction unit 100 proposed in this embodiment of the present invention integrates the first cavity 101 to the sixth cavity 106. During the nucleic acid extraction process, all operations can be performed on a single extraction unit 100, significantly reducing the number of consumables and making production, packaging, and transportation more convenient. Moreover, all extraction operations are performed on a single extraction unit 100, which can simplify the detection process and improve detection efficiency.

[0128] As shown in Figures 3 and 9, in one embodiment, the extraction member 100 further includes a first pipetting head 21 and a second pipetting head 22. The first pipetting head 21 is housed in the third cavity 103, and the second pipetting head 22 is housed in the fourth cavity 104. In one embodiment, the volume of the first pipetting head 21 is smaller than that of the second pipetting head 22. For example, the volume of the first pipetting head 21 is 300 μL, and the volume of the second pipetting head 22 is 1000 μL. Of course, the volume of the first pipetting head 21 and the volume of the second pipetting head 22 can also be the same, depending on actual design requirements.

[0129] As shown in FIG10 , in one embodiment, a first step 1031 or a first stop is provided on the sidewall of the third cavity 103, near the opening of the third cavity 103. The outer sidewall of the first pipetting head 21 has a first hanging portion 211. When the first pipetting head 21 is accommodated in the third cavity 103, the first step 1031 or the first stop abuts against the first hanging portion 211 of the first pipetting head 21 to position the first pipetting head 21. In this embodiment, the positioning effect of the first step 1031 or the first stop and the first hanging portion 211 prevents the tip of the first pipetting head 21 from contacting the bottom wall of the third cavity 103 when the first pipetting head 21 is accommodated in the third cavity 103. This also facilitates the loading and unloading of the first pipetting head 21 from the third cavity 103 by the liquid transfer assembly.

[0130] As shown in FIG10 , in one embodiment, a second step 1041 or a second stop is provided on the sidewall of the fourth cavity 104 near the opening of the fourth cavity 104. The outer sidewall of the second pipetting head 22 has a second hanging portion 221. When the second pipetting head 22 is accommodated in the fourth cavity 104, the second step 1041 or the second stop abuts against the second hanging portion 221 of the second pipetting head 22 to position the second pipetting head 22. In this embodiment, the positioning effect of the second step 1041 or the second stop and the second hanging portion 221 prevents the tip of the second pipetting head 22 from contacting the bottom wall of the fourth cavity 104 when the second pipetting head 22 is accommodated in the fourth cavity 104. This also facilitates the liquid transfer assembly in loading and unloading the second pipetting head 22 from the fourth cavity 104.

[0131] As shown in FIG11 , in one embodiment, a first protrusion 1032 is provided at the bottom of the third cavity 103. The first protrusion 1032 is configured to contact the liquid on the needle tip of the first pipetting head 21, thereby reducing the amount of liquid on the needle tip of the first pipetting head 21. In one embodiment, when the first pipetting head 21 is housed in the third cavity 103, the distance between the first protrusion 1032 and the needle tip of the first pipetting head 21 is very small, for example, 2-3 mm. Liquid on the needle tip of the first pipetting head 21 contacts the protrusion and, guided by the protrusion, flows into the third cavity 103, thereby reducing the amount of liquid on the needle tip of the first pipetting head 21. With this embodiment, when the first pipetting head 21 is subsequently used, liquid on the first pipetting head 21 can be prevented from dripping onto the extraction unit 100 or the working station of the sample testing device 1000, thereby contaminating the first pipetting head 21 or the sample testing device 1000. In one embodiment, the first protrusion 1032 is a conical structure. Of course, it is not limited to a cone, and can also be other shapes, such as a cross, a semicircle or other irregular shapes. The specific shape can be determined according to actual design needs, as long as the first protrusion 1032 can reduce the amount of liquid hanging on the needle tip of the first pipetting head 21.

[0132] As shown in FIG12 , in one embodiment, a second protrusion 1042 is provided at the bottom of the fourth chamber 104. The second protrusion 1042 is configured to contact the liquid on the needle tip of the second pipetting head 22, thereby reducing the amount of liquid on the needle tip of the second pipetting head 22. In one embodiment, when the second pipetting head 22 is housed in the fourth chamber 104, the distance between the second protrusion 1042 and the needle tip of the second pipetting head 22 is very small, for example, 2-3 mm. Liquid on the needle tip of the second pipetting head 22 contacts the protrusion and, guided by the protrusion, flows into the fourth chamber 104, thereby reducing the amount of liquid on the needle tip of the second pipetting head 22. This embodiment prevents liquid from dripping onto the extraction unit 100 or the working station of the sample testing device 1000 when the second pipetting head 22 is subsequently used, thereby contaminating the second pipetting head 22 or the sample testing device 1000. In one embodiment, the second protrusion 1042 is a conical structure. Of course, it is not limited to a cone, and can also be other shapes, such as a cross, a semicircle or other irregular shapes. The specific shape can be determined according to actual design needs, as long as the second protrusion 1042 can reduce the amount of liquid hanging on the needle tip of the first pipetting head 21.

[0133] As shown in FIG13 , in one embodiment, a first flow-guiding structure 1011 is provided on the sidewall of the first cavity 101, extending from the opening of the first cavity 101 to the bottom of the first cavity 101. In this embodiment, by providing the first flow-guiding structure 1011 on the sidewall of the first cavity 101 to guide the liquid injected into the first cavity 101, tumbling of the liquid injected into the first cavity 101 can be prevented, thereby preventing the formation of aerosols and reducing the risk of infection for testing personnel.

[0134] As shown in FIG. 13 , in some embodiments, the first cavity 101 has a first central axis L1 , and the first flow guide structure 1011 includes a first inclined surface 1012 , which extends obliquely from the edge of the opening of the first cavity 101 toward the first central axis L1 .

[0135] It should be noted that the first inclined surface 1012 is not limited to being disposed at the opening edge of the first cavity 101 , but may also be disposed in the middle or bottom of the first cavity 101 .

[0136] It should also be noted that the first flow-guiding structure 1011 is not limited to being set as the first inclined surface 1012. For example, in some other embodiments, the first flow-guiding structure 1011 includes a second spiral surface, which spirally extends from the edge of the opening of the first cavity 101 around the first central axis L1 toward the bottom of the first cavity 101.

[0137] As shown in FIG13 , in some embodiments, the first inclined surface 1012 has an inclination angle α1 relative to the first central axis L1, where α1 = 15°-45°. For example, the inclination angle of the first inclined surface 1012 relative to the first central axis L1 is 15°, 20°, 25°, 30°, 35°, 40°, 45°, or any value between 15°, 20°, 25°, 30°, 35°, 40°, and 45°. In this embodiment, the inclination angle of the first inclined surface 1012 relative to the first central axis L1 is 27.5°.

[0138] As shown in Figure 13, in some embodiments, the wall of the first cavity 101 also includes a first wall 1013 and a second wall 1014, the first wall 1013 is connected between the first inclined surface 1012 and the second wall 1014, the second wall 1014 extends from the bottom end of the first wall 1013 to the bottom of the first cavity 101, and the inclination angle of the first wall 1013 relative to the first central axis L1 is α2, α2=0°~2°, and the inclination angle of the second wall 1014 relative to the first central axis L1 is β3, β3=5°~45°.

[0139] As shown in FIG13 , in some embodiments, the wall surface of the first cavity 101 further includes a first wall surface 1013, and the first flow-guiding structure 1011 further includes a curved surface 1015. The curved surface 1015 is connected between the first inclined surface 1012 and the first wall surface 1013. The first wall surface 1013 extends from the curved surface 1015 toward the bottom of the first cavity 101. The curved surface 1015 is used to achieve a smooth transition between the first inclined surface 1012 and the first wall surface 1013. In this embodiment, the liquid injected into the first cavity 101 can flow horizontally along the wall surface of the first cavity 101, thereby preventing liquid splashing on the wall surface of the first cavity 101 and causing the formation of aerosols.

[0140] As shown in FIG13 , in some embodiments, the depth of the first inclined surface 1012 is 0.2 to 0.3 of the total depth of the first cavity 101. The depth of the first inclined surface 1012 refers to the height of the first inclined surface 1012 along the first central axis L1, and the total depth of the first cavity 101 refers to the total height of the first cavity 101 along the first central axis L1.

[0141] As shown in FIG13 , in one embodiment, a second flow-guiding structure 1061 is provided on the sidewall of the sixth cavity 106. The second flow-guiding structure 1061 extends from the opening of the sixth cavity 106 to the bottom of the sixth cavity 106. In this embodiment, by providing the second flow-guiding structure 1061 on the sidewall of the sixth cavity 106 to guide the liquid injected into the sixth cavity 106, the liquid injected into the sixth cavity 106 can be prevented from rolling, thereby preventing the formation of aerosols and reducing the risk of infection for testing personnel.

[0142] As shown in FIG13 , in some embodiments, the sixth chamber 106 has a second central axis L2, and the second flow-guiding structure 1061 includes a second inclined surface 1062. The second inclined surface 1062 extends obliquely from the edge of the opening of the sixth chamber 106 toward the second central axis L2. In actual use, waste liquid injected into the sixth chamber 106 is directly discharged into the second inclined surface 1062 and then flows to the bottom of the sixth chamber 106 under the guidance of the second inclined surface 1062.

[0143] It should be noted that the second inclined surface 1062 is not limited to being disposed at the opening edge of the sixth cavity 106 , but may also be disposed in the middle or bottom of the sixth cavity 106 .

[0144] It should also be noted that the second flow-guiding structure 1061 is not limited to being set as the second inclined surface 1062. For example, in some other embodiments, the second flow-guiding structure 1061 includes a first spiral surface, which spirally extends from the edge of the opening of the sixth cavity 106 around the second central axis L2 toward the bottom of the sixth cavity 106.

[0145] As shown in FIG13 , in some embodiments, the second inclined surface 1062 has an inclination angle β1 relative to the second central axis L2, where β1 = 5° to 45°. For example, the inclination angle of the second inclined surface 1062 relative to the second central axis L2 is 5°, 10°, 15°, 20°, 25°, 30°, 35°, 40°, 45°, or any value between adjacent ones of 5°, 10°, 15°, 20°, 25°, 30°, 35°, 40°, and 45°. In this embodiment, the inclination angle of the second inclined surface 1062 relative to the second central axis L2 is 6.8°.

[0146] As shown in FIG13 , in some embodiments, the sidewall of the sixth cavity 106 further includes a third wall surface 1063 , which extends from the bottom end of the second inclined surface 1062 to the bottom of the sixth cavity 106 , and an inclination angle of the third wall surface 1063 relative to the second central axis L2 is β2, β2 = 0° to 2°.

[0147] As shown in FIG13 , in some embodiments, the depth of the second inclined surface 1062 is 0.3 to 0.5 of the total depth of the sixth cavity 106. The depth of the second inclined surface 1062 refers to the height of the second inclined surface 1062 along the second central axis L2, and the total depth of the sixth cavity 106 refers to the total height of the sixth cavity 106 along the second central axis L2.

[0148] As shown in Figures 9 and 14, in one embodiment, the extraction member 100 includes a strip 11 and at least two tubes 12. The strip 11 includes a first side 11a and a second side 11b opposite the first side 11a in the thickness direction X. The strip 11 is provided with at least two openings, which are arranged along the length of the strip 11 and penetrate the strip 11 in the thickness direction X. The at least two tubes 12 are provided on the second side 11b of the strip 11. The at least two tubes 12 are in one-to-one communication with the at least two openings. The inner cavity of one tube 12 forms a first cavity 101, and the inner cavity of the other tube 12 forms a second cavity 102.

[0149] As shown in FIG15 , in one embodiment, the strip 11 includes a first end surface 11 c and a second end surface 11 d opposite the first end surface 11 c in the length direction Y. The first end surface 11 c is recessed toward the second end surface 11 d to form a first positioning groove 111, and the second end surface 11 d is recessed toward the first end surface 11 c to form a second positioning groove 112. The first positioning groove 111 and the second positioning groove 112 are used to position the extraction member 100 when the clamping jaws of the scheduling assembly 208 clamp the extraction member 100.

[0150] During actual sample testing, the clamping jaws need to grip the extraction member 100 and place it at multiple workstations. If there is an error in the gripping of the extraction member 100 by the clamping jaws, the extraction member 100 cannot be smoothly placed at multiple workstations. In this embodiment, the first end surface 11c of the strip 11 is recessed toward the second end surface 11d to form a first positioning groove 111, and the second end surface 11d is recessed toward the first end surface 11c to form a second positioning groove 112. When the clamping jaws grip the extraction member 100, the extraction member 100 can be positioned, thereby enabling smooth placement at multiple workstations.

[0151] As shown in FIG15 , in one embodiment, the width of the first positioning groove 111 gradually increases from the bottom of the first positioning groove 111 toward the groove opening; the width of the second positioning groove 112 gradually increases from the bottom of the second positioning groove 112 toward the groove opening.

[0152] As shown in FIG15 , in one embodiment, the first positioning groove 111 and the second positioning groove 112 are V-shaped. Accordingly, a V-shaped protrusion is provided on the clamping jaw. In this embodiment, when the protrusion on the clamping jaw engages with the first positioning groove 111 and the second positioning groove 112, the side surface of the protrusion can be tightly fitted with the wall surface of the first positioning groove 111 and the second positioning groove 112, thereby achieving precise positioning. Furthermore, because the openings of the first positioning groove 111 and the second positioning groove 112 are relatively large and the tip profile of the protrusion is relatively small, when the clamping jaw clamps the extraction member 100, it is very convenient for the protrusion to fit into the first positioning groove 111 and the second positioning groove 112, thereby reducing the difficulty of clamping.

[0153] As shown in Figures 15 and 16 , in one embodiment, the strip 11 includes a third side surface 11e and a fourth side surface 11f opposite the third side surface 11e in the width direction Z. One of the third side surface 11e and the fourth side surface 11f is provided with a protrusion 113, and the other of the third side surface 11e and the fourth side surface 11f is provided with a retaining groove 114. The protrusion 113 and the retaining groove 114 are aligned and complementary in the width direction Z. The two extraction members 100 are positioned relative to each other through the engagement of the protrusion 113 and the retaining groove 114. In this embodiment, when two extraction members 100 are stacked in the width direction Z of the strip 11, the protrusion 113 of one extraction member 100 can engage with the retaining groove 114 of the other extraction member 100, restricting the two extraction members 100 from sliding in the length direction Y. This not only facilitates packaging of the rows of extraction members 100 but also facilitates their insertion into the sample testing device 1000.

[0154] As shown in FIG14 , in one embodiment, a groove 115 is provided on the first side 11a of the strip 11. The projections of the groove 115 and the opening on a plane perpendicular to the thickness direction X of the strip 11 do not overlap. In this embodiment, by providing the groove 115 on the first side 11a of the strip 11, the first and second pipetting heads 21 and 22 can drop liquid onto the groove 115. The groove 115 can retain the liquid, preventing it from dripping from the extraction element onto the workstation, thereby keeping the workstation clean and reducing contamination.

[0155] As shown in FIG14 , in one embodiment, there are six openings, namely, a first opening, a second opening, a third opening, a fourth opening, a fifth opening, and a sixth opening, arranged in sequence. There are six tubes 12, namely, a first tube 12a, a second tube 12b, a third tube 12c, a fourth tube 12d, a fifth tube 12e, and a sixth tube 12f, arranged in sequence. The first tubes 12a to 12f are in one-to-one communication with the first to sixth openings. The inner cavity of the first tube 12a forms a first cavity 101, and the inner cavity of one of the second tube 12b and the third tube 12c forms a second cavity 102. The length of the first tube 12a is greater than the lengths of the second tube 12b and the third tube 12c.

[0156] As shown in Figures 17 to 19, in one embodiment, the sum of the length of the first tube body 12a and the length of the sixth tube body 12f is t1, the sum of the length of the second tube body 12b and the length of the fifth tube body 12e is t2, and the sum of the length of the third tube body 12c and the length of the fourth tube body 12d is t3, wherein t1≥t2, and t1≥t3. The first tube body 12a includes a first tube segment 12a1 and a second tube segment 12a2, the first tube segment 12a1 includes a first end and a second end, the first end of the first tube segment 12a1 is connected to the strip 11, and the second tube segment 12a2 is connected to the second end of the first tube segment 12a1, the fourth tube body 12d includes a third tube segment 12d1 and a fourth tube segment 12d2, the third tube segment 12d1 includes a first end and a second end, the first end of the third tube segment 12d1 is connected to the strip 11, and the fourth tube segment 12d2 is connected to the second end of the third tube segment 12d1, wherein the distance between the second tube segment 12a2 and the fourth tube segment 12d2 is S1, and the distance between the fourth tube segment 12d2 and the opposite sides of the fifth tube body 12e is S2, and S1>S2. In this embodiment, the space between the first tube body 12a and the fourth tube body 12d can be reasonably utilized to place the two extraction members 100 in reverse and cross-positioned manner. The occupation of the extraction members 100 is not only convenient for packaging but also for transportation.

[0157] Specifically, the length of the first tube body 12a is M1, the length of the sixth tube body 12f is M2, M1+M2=t1, the length of the second tube body 12b is M3, the length of the fifth tube body 12e is M4, M3+M4=t2, the length of the third tube body 12c is M5, and the length of the fourth tube body 12d is M6, M5+M6=t3.

[0158] As shown in Figures 3, 9, 14, and 15, an embodiment of the present invention further provides an extraction member 100. The extraction member 100 includes a strip 11 and at least two tubes 12. The strip 11 includes a first side 11a and a second side 11b opposite the first side 11a in the thickness direction X. The strip 11 is provided with at least two openings, which are arranged along the length direction Y of the strip 11 and penetrate the strip 11 in the thickness direction X. The at least two tubes 12 are provided on the second side 11b of the strip 11, and the at least two tubes 12 are connected to the at least two openings in a one-to-one correspondence. The strip 11 includes a first end face 11c and a second end face 11d opposite the first end face 11c in the length direction Y. The first end face 11c is recessed toward the second end face 11d to form a first positioning groove 111, and the second end face 11d is recessed toward the first end face 11c to form a second positioning groove 112.

[0159] The extraction member 100 proposed in this embodiment forms a first positioning groove 111 by recessing the first end face 11c of the strip member 11 toward the second end face 11d, and forms a second positioning groove 112 by recessing the second end face 11d toward the first end face 11c. When the clamping jaws clamp the extraction member 100, they can position the extraction member 100, so that the extraction member 100 can be smoothly taken and placed at multiple workstations.

[0160] In one embodiment, the width of the first positioning groove 111 gradually increases from the bottom toward the groove opening of the first positioning groove 111. The width of the second positioning groove 112 gradually increases from the bottom toward the groove opening of the second positioning groove 112.

[0161] In one embodiment, the first positioning groove 111 and the second positioning groove 112 are V-shaped. Accordingly, a V-shaped protrusion 113 is provided on the clamping jaw. In this embodiment, when the protrusion 113 on the clamping jaw engages with the first positioning groove 111 and the second positioning groove 112, the side surface of the protrusion 113 can be tightly fitted with the wall surface of the first positioning groove 111 and the second positioning groove 112, thereby achieving precise positioning. Moreover, because the openings of the first positioning groove 111 and the second positioning groove 112 are relatively large and the tip profile of the protrusion 113 is relatively small, when the clamping jaw clamps the extraction member 100, it is very convenient for the protrusion 113 to be embedded in the first positioning groove 111 and the second positioning groove 112, thereby reducing the difficulty of clamping.

[0162] The other structures and beneficial effects of the extraction member 100 proposed in this embodiment can be referred to the above embodiments and will not be described in detail here.

[0163] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in the present invention, and such modifications or substitutions are intended to be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of protection of the claims.

Claims

1. A sample detection device, characterized in that, Comprising a reagent storage component, a reagent dispensing component, a sample dispensing component, an extraction component, an amplification component, a detection component, a first liquid transfer component, a scheduling component and a controller, the sample detection device further forms a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component is at least used for storing a first reagent container and a second reagent container. The first reagent container is used for storing a first reagent, and the second reagent container is used for storing a second reagent. The reagent dispensing component is used for dispensing the first reagent stored in the first reagent container and the second reagent stored in the second reagent container in the reagent storage component to an extraction piece located at the reagent dispensing station. The sample dispensing component is used for dispensing a sample to an extraction piece located at the sample dispensing station. The extraction component is used for nucleic acid extraction of the liquid in the extraction piece located at the extraction station. The first liquid transfer component is used for transferring the liquid in the extraction piece located at the liquid transfer station to an amplification tube located at the liquid transfer station. The amplification component is used for performing amplification processing on the liquid in the amplification tube located at the amplification station. The detection component is used for detecting the liquid in the amplification tube located at the detection station. The scheduling component is used for scheduling the extraction piece among the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station. The scheduling component is further used for scheduling the amplification tube among the liquid transfer station, the amplification station and the detection station. The controller is configured to: Control the reagent dispensing component to dispense the first reagent in the first reagent container in the reagent storage component to the first cavity of the extraction piece located at the reagent dispensing station, and to dispense the second reagent in the second reagent container in the reagent storage component to the second cavity of the extraction piece located at the reagent dispensing station; Control the scheduling component to schedule the extraction piece from the reagent dispensing station to the sample dispensing station, and control the sample dispensing component to dispense the sample into the first cavity; Control the scheduling component to schedule the extraction piece that has been dispensed with the sample at the sample dispensing station to the extraction station, and control the extraction component to perform nucleic acid extraction on the liquid in the first cavity; Control the scheduling component to transfer the extraction piece that has completed nucleic acid extraction at the extraction station to the liquid transfer station, control the first liquid transfer component to transfer at least part of the liquid that has completed nucleic acid extraction in the first cavity to the amplification tube located at the liquid transfer station, and then control the first liquid transfer component to transfer the second reagent in the second cavity to the amplification tube located at the liquid transfer station; Control the scheduling component to schedule the amplification tube to the amplification station, control the amplification component to perform amplification processing on the liquid in the amplification tube, control the scheduling component to schedule the amplification tube after the amplification processing at the amplification station to the detection station, and control the detection component to detect the liquid in the amplification tube located at the detection station.

2. The sample detection device according to claim 1, wherein The sample detection device further includes a first loading component, and the first loading component is used to load the first pipette tip in the third cavity of the extraction part to the first liquid transfer component, so that the first liquid transfer component can aspirate liquid through the first pipette tip.

3. The sample detection device according to claim 1, wherein, The reagent storage component is further used to store a third reagent container, and the third reagent container is used to store an elution reagent. Before scheduling the extraction part to the sample dispensing station, the controller also controls the reagent dispensing component to dispense the elution reagent in the third reagent container in the reagent storage component to the fourth cavity of the extraction part. The first reagent includes a magnetic bead reagent; the extraction component includes a carrier, an incubation part, a first magnetic attraction part, a first liquid transfer part, and a second liquid transfer part. The carrier is provided with a liquid aspiration station and an elution station. The carrier is used to carry the extraction part. The first magnetic attraction part is used to perform a magnetic attraction operation on the extraction part located at the liquid aspiration station to gather the magnetic beads in the extraction part on the bottom wall or side wall of the first cavity of the extraction part. The first liquid transfer part is used to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part located at the liquid aspiration station. The second liquid transfer part is used to inject the elution reagent in the fourth cavity of the extraction part into the first cavity of the extraction part located at the elution station. Controlling the extraction component to perform nucleic acid extraction on the liquid in the first cavity includes: Control the scheduling component to schedule the extraction part located at the sample dispensing station to the incubation part for incubation; Control the scheduling component to schedule the incubated extraction part to the liquid aspiration station, and control the first liquid transfer part to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part; Control the scheduling component to schedule the extraction part after the liquid aspiration operation to the elution station, and control the second liquid transfer part to inject the elution reagent in the fourth cavity of the extraction part into the first cavity of the extraction part.

4. The sample detection device according to claim 3, wherein, The sample detection device further includes a second loading component, and the second loading component is used to load the first pipette tip in the third cavity of the extraction part to the second liquid transfer part, so that the second liquid transfer part can aspirate liquid through the first pipette tip.

5. The sample detection device according to claim 3, wherein The sample detection device further includes a cleaning liquid supply component. The extraction component further includes a second magnetic attraction part and a third liquid transfer part. The carrier is further provided with a cleaning station. The cleaning liquid supply component is used to inject cleaning liquid into the first cavity of the extraction part located at the cleaning station. The second magnetic attraction part is used to perform a magnetic attraction operation on the extraction part located at the cleaning station to gather the magnetic beads in the extraction part on the bottom wall or side wall of the first cavity of the extraction part. The third liquid transfer part is used to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part located at the cleaning station. The controller is further configured to: Control the scheduling component to schedule the extraction part located at the liquid suction station and having completed the liquid suction operation to the cleaning station; Control the cleaning liquid supply component to inject the cleaning liquid into the extraction part located at the cleaning station, and control the third pipetting part to perform a liquid suction operation on the liquid in the first cavity of the extraction part after the magnetic attraction operation is completed; Control the scheduling component to schedule the extraction part after the liquid suction operation is completed to the elution station.

6. The sample detection device according to claim 5, wherein The sample detection device further includes a second loading component, which is used to load the second pipetting head in the fifth cavity of the extraction part onto the first pipetting part or the third pipetting part, so that the first pipetting part or the third pipetting part can suck the liquid through the second pipetting head.

7. The sample detection device according to claim 5, characterized in that The controller is further configured to: control the first pipetting part and the third pipetting part to transfer the sucked liquid to the sixth cavity of the extraction part.

8. The sample detection device according to claim 1, characterized in that, The sample detection device further includes a lid closing component for grasping the tube lid of the amplification tube and closing the grasped tube lid to the open end of the amplification tube. After the first liquid transfer component transfers the second reagent in the second cavity to the inside of the amplification tube, the controller is further configured to: Control the lid closing component to close the tube lid to the open end of the amplification tube located at the liquid transfer station.

9. The sample detection device according to claim 1, wherein The second reagent includes a reagent for liquid-sealing the liquid containing nucleic acid in the amplification tube.

10. The sample detection device according to claim 1, characterized in that, There are at least two types of the first reagent. Controlling the reagent dispensing component to dispense the first reagent in the first reagent container in the reagent storage component into the first cavity of the extraction part includes: Controlling the reagent dispensing component to sequentially suck at least two types of the first reagent from the first reagent container, and then controlling the reagent dispensing component to inject the sucked at least two types of the first reagent into the first cavity at one time.

11. The sample detection device according to claim 1, wherein, The sample detection device further includes a housing and a partition board. The housing has a receiving cavity. The partition board is disposed in the receiving cavity to divide the receiving cavity into a reagent cavity and a sample cavity. The reagent dispensing component is located in the reagent cavity, and the sample dispensing component is located in the sample cavity. The partition board is provided with an opening, and the opening is used for the scheduling component to schedule the extraction part only from the reagent dispensing station to the sample dispensing station.

12. A sample detection device, characterized in that, Comprising a reagent storage component, a reagent dispensing component, a sample dispensing component, an extraction component, an amplification component, a detection component, a first liquid transfer component, a scheduling component and a controller, the sample detection device further forms a reagent dispensing station, a sample dispensing station, an extraction station, a liquid transfer station, an amplification station and a detection station. The reagent storage component is at least used for storing a first reagent container and a second reagent container. The first reagent container is used for storing a first reagent, and the second reagent container is used for storing a second reagent. The reagent dispensing component is used for dispensing the first reagent stored in the first reagent container in the reagent storage component and the second reagent stored in the second reagent container to an extraction piece located at the reagent dispensing station. The sample dispensing component is used for dispensing a sample to an extraction piece located at the sample dispensing station. The extraction component is used for performing nucleic acid extraction on the liquid in the extraction piece located at the extraction station. The first liquid transfer component is used for transferring the liquid in the extraction piece located at the liquid transfer station to an amplification tube located at the liquid transfer station. The amplification component is used for performing amplification processing on the liquid in the amplification tube located at the amplification station. The detection component is used for detecting the liquid in the amplification tube located at the detection station. The scheduling component is used for scheduling the extraction piece among the reagent dispensing station, the sample dispensing station, the extraction station and the liquid transfer station. The scheduling component is further used for scheduling the amplification tube among the liquid transfer station, the amplification station and the detection station. The controller is configured to: Control the reagent dispensing component to dispense the first reagent in the first reagent container in the reagent storage component to the first cavity of the extraction piece located at the reagent dispensing station, and to dispense the second reagent in the second reagent container in the reagent storage component to the second cavity of the extraction piece located at the reagent dispensing station; Control the scheduling component to schedule the extraction piece from the reagent dispensing station to the sample dispensing station, and control the sample dispensing component to dispense the sample into the first cavity; Control the scheduling component to schedule the extraction piece that has been dispensed with the sample at the sample dispensing station to the extraction station, and control the extraction component to perform nucleic acid extraction on the liquid in the first cavity. During the nucleic acid extraction process, the second reagent is transferred from the second cavity to the first cavity of the extraction piece; Control the scheduling component to transfer the extraction piece that has completed nucleic acid extraction at the extraction station to the liquid transfer station, and control the first liquid transfer component to transfer at least part of the liquid that has completed nucleic acid extraction in the first cavity to an amplification tube located at the liquid transfer station; Control the scheduling component to schedule the amplification tube to the amplification station, control the amplification component to perform amplification processing on the liquid in the amplification tube, control the scheduling component to schedule the amplification tube that has completed amplification processing at the amplification station to the detection station, and control the detection component to detect the liquid in the amplification tube located at the detection station.

13. The sample detection device according to claim 12, wherein, The sample detection device further includes a first loading component, which is used to load the first pipetting head in the third cavity of the extraction part into the first liquid transfer component, so that the first liquid transfer component can aspirate liquid through the first pipetting head.

14. The sample detection device according to claim 12, characterized in that, The second reagent is an elution reagent, and the first reagent includes a magnetic bead reagent; the extraction component further includes a carrier, an incubation part, a first magnetic attraction part, a first liquid transfer part, and a second liquid transfer part. The carrier is provided with a liquid aspiration station and an elution station. The carrier is used to carry the extraction part. The first magnetic attraction part is used to perform a magnetic attraction operation on the extraction part located at the liquid aspiration station, so as to gather the magnetic beads in the extraction part on the bottom wall or side wall of the first cavity of the extraction part. The first liquid transfer part is used to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part located at the liquid aspiration station. The second liquid transfer part is used to inject the elution reagent in the second cavity of the extraction part into the first cavity of the extraction part located at the elution station. Controlling the extraction component to perform nucleic acid extraction on the liquid in the first cavity includes: Controlling the scheduling component to schedule the extraction part located at the sample dispensing station to the incubation part for incubation; Controlling the scheduling component to schedule the incubated extraction part to the liquid aspiration station, and controlling the first liquid transfer part to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part; Controlling the scheduling component to schedule the extraction part after the liquid aspiration operation is completed to the elution station, and controlling the second liquid transfer part to inject the elution reagent in the second cavity of the extraction part into the first cavity of the extraction part.

15. The sample detection device according to claim 12, characterized in that, The sample detection device further includes a second loading component, which is used to load the first pipetting head in the third cavity of the extraction part into the second liquid transfer part, so that the second liquid transfer part can aspirate liquid through the first pipetting head.

16. The sample detection device according to claim 14, wherein, The sample detection device further includes a cleaning liquid providing component. The extraction component further includes a second magnetic attraction part and a third liquid transfer part. The carrier is further provided with a cleaning station. The cleaning liquid providing component is used to inject cleaning liquid into the first cavity of the extraction part located at the cleaning station. The second magnetic attraction part is used to perform a magnetic attraction operation on the extraction part located at the cleaning station, so as to gather the magnetic beads in the extraction part on the bottom wall or side wall of the first cavity of the extraction part. The third liquid transfer part is used to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part located at the cleaning station. The controller is further configured to: Control the scheduling component to schedule the extraction part located at the liquid aspiration station and after the liquid aspiration operation is completed to the cleaning station; Control the cleaning liquid providing component to inject the cleaning liquid into the extraction part located at the cleaning station, and control the third liquid transfer part to perform a liquid aspiration operation on the liquid in the first cavity of the extraction part after the magnetic attraction operation is completed; Control the scheduling component to schedule the extraction part after the liquid aspiration operation is completed to the elution station.

17. The sample detection device according to claim 16, characterized in that, The sample detection device further includes a second loading component, which is used to load the second pipetting head in the fourth cavity of the extraction member into the first pipetting member or the third pipetting member, so that the first pipetting member or the third pipetting member can aspirate liquid through the second pipetting head.

18. The sample detection device according to claim 16, characterized in that, The controller is further configured to: control the first pipetting member and the third pipetting member to transfer the aspirated liquid to the sixth cavity of the extraction member.

19. The sample detection device according to claim 12, characterized in that, There are at least two types of the first reagent. Controlling the reagent dispensing component to dispense the first reagent in the first reagent container in the reagent storage component into the first cavity in the extraction member includes: Controlling the reagent dispensing component to sequentially aspirate at least two types of the first reagent from the first reagent container, and then controlling the reagent dispensing component to inject the aspirated at least two types of the first reagent into the first cavity at one time.

20. The sample detection device according to claim 12, wherein, The sample detection device further includes a lid closing component, which is used to grasp the tube cap of the amplification tube and cover the grasped tube cap on the open end of the amplification tube. After the first liquid transfer component transfers the second reagent in the second cavity into the amplification tube, the controller is further configured to: Control the lid closing component to cover the tube cap on the open end of the amplification tube located at the liquid transfer station.

21. An extraction component, which is applied to a molecular diagnostic device. At least a reagent dispensing component and a sample dispensing component are provided in the housing of the molecular diagnostic device. It is characterized in that, The extraction member includes an open first cavity and a second cavity. The first cavity is used to accommodate the first reagent injected by the reagent dispensing component and the sample injected by the sample dispensing component, and the second cavity is used to accommodate the second reagent injected by the reagent dispensing component.

22. The extraction member according to claim 21, wherein, The extraction member further includes an open third cavity and a fourth cavity. The third cavity is used to accommodate the first pipetting head, and the fourth cavity is used to accommodate the second pipetting head. The volume of the second pipetting head is larger than that of the first pipetting head; and / or, The extraction member further includes an open fifth cavity, which is used to accommodate the third reagent injected by the molecular diagnostic device; and / or, The extraction member further includes an open sixth cavity, which is used to accommodate waste liquid.

23. The extraction part according to claim 22, wherein, The extraction member further includes a first pipetting head and a second pipetting head. The first pipetting head is accommodated in the third cavity, and the second pipetting head is accommodated in the fourth cavity.

24. The extraction member according to claim 22, wherein A first step or a first stop portion is provided on the side wall of the third cavity and near the opening of the third cavity; and / or, A second step or a second stop portion is provided on the side wall of the fifth cavity and near the opening of the fifth cavity; and / or, A first protrusion is provided at the bottom of the third cavity; and / or, A second protrusion is provided at the bottom of the fourth cavity.

25. The extraction part according to claim 21, wherein A first diversion structure is provided on the side wall of the first cavity, and the first diversion structure extends from the opening of the first cavity to the bottom of the first cavity.

26. The extraction part according to claim 21, wherein, A second diversion structure is provided on the side wall of the sixth cavity, and the second diversion structure extends from the opening of the sixth cavity to the bottom of the sixth cavity.

27. The extraction part according to claim 21, wherein, Including: A bar-shaped member, including a first side and a second side opposite to the first side in the thickness direction of the bar-shaped member. The bar-shaped member is provided with at least two openings, and the at least two openings are arranged along the length direction of the bar-shaped member and penetrate through the bar-shaped member in the thickness direction. At least two pipe bodies are arranged on the second side of the bar-shaped member, and the at least two pipe bodies are in one-to-one correspondence and communication with the at least two openings. The inner cavity of one of the pipe bodies forms the first cavity, and the inner cavity of the other pipe body forms the second cavity.

28. The extraction part according to claim 27, wherein The bar-shaped member includes a first end face and a second end face opposite to the first end face in the length direction. The first end face is recessed towards the second end face to form a first positioning groove, and the second end face is recessed towards the first end face to form a second positioning groove.

29. The extraction part according to claim 28, characterized in that, The width of the first positioning groove gradually increases from the bottom of the first positioning groove towards the notch direction; the width of the second positioning groove gradually increases from the bottom of the second positioning groove towards the notch direction.

30. The extraction part according to claim 29, characterized in that, The shapes of the first positioning groove and the second positioning groove are V-shaped.

31. The extraction part according to claim 27, characterized in that, The bar-shaped member includes a third side face and a fourth side face opposite to the third side face in the width direction. One of the third side face and the fourth side face is provided with a protrusion, and the other of the third side face and the fourth side face is provided with a card slot. The protrusion and the card slot are opposite to each other in the width direction and are complementary in shape.

32. The extraction member according to claim 27, wherein A groove is provided on the first side of the bar-shaped member, and the projections of the groove and the opening on a plane perpendicular to the thickness direction of the bar-shaped member do not overlap.

33. The extraction part according to claim 27, characterized in that, The number of the openings is six, which are respectively a first opening, a second opening, a third opening, a fourth opening, a fifth opening and a sixth opening arranged in sequence; The number of the pipe bodies is six, which are respectively a first pipe body, a second pipe body, a third pipe body, a fourth pipe body, a fifth pipe body and a sixth pipe body arranged in sequence. The first pipe body to the sixth pipe body are in one-to-one correspondence and communication with the first opening to the sixth opening. The inner cavity of the first pipe body forms the first cavity, and the inner cavity of one of the second pipe body and the third pipe body forms the second cavity; The length of the first pipe body is greater than the lengths of the second pipe body and the third pipe body.

34. The extraction part according to claim 33, characterized in that The sum of the lengths of the first pipe body and the sixth pipe body is t1, the sum of the lengths of the second pipe body and the fifth pipe body is t2, and the sum of the lengths of the third pipe body and the fourth pipe body is t3. Wherein, t1≥t2 and t1≥t3; The first pipe body includes a first pipe section and a second pipe section. The first pipe section includes a first end and a second end. The first end of the first pipe section is connected to the bar-shaped member, and the second pipe section is connected to the second end of the first pipe section. The fourth pipe body includes a third pipe section and a fourth pipe section. The third pipe section includes a first end and a second end. The first end of the third pipe section is connected to the bar-shaped member, and the fourth pipe section is connected to the second end of the third pipe section. Wherein, the distance between the second pipe section and the fourth pipe section is S1, and the distance between the two sides of the fourth pipe section and the fifth pipe body facing away from each other is S2, and S1>S2.

35. An extraction part, characterized in that, Including: A bar-shaped member, including a first side and a second side opposite to the first side in the thickness direction of the bar-shaped member, the bar-shaped member being provided with at least two openings, the at least two openings being arranged along the length direction of the bar-shaped member and penetrating the bar-shaped member in the thickness direction; At least two tubular bodies are provided on the second side of the bar-shaped member, and the at least two tubular bodies are in one-to-one correspondence and communication with the at least two openings; Wherein, the bar-shaped member includes a first end face and a second end face opposite to the first end face in the length direction, the first end face is recessed towards the second end face to form a first positioning groove, and the second end face is recessed towards the first end face to form a second positioning groove.

36. The extraction part according to claim 35, characterized in that, The width of the first positioning groove gradually increases from the bottom of the first positioning groove towards the notch direction; the width of the second positioning groove gradually increases from the bottom of the second positioning groove towards the notch direction.

37. The extraction member according to claim 36, wherein The shapes of the first positioning groove and the second positioning groove are V-shaped.

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