A liver-protecting high-absorption composition of jiejiushuang and a preparation method thereof

Abstract

The present application belongs to the technical field of liver-protecting functional food, and particularly relates to a liver-protecting high-absorption hangover-relieving composition and a preparation method thereof.The technical scheme is a liver-protecting high-absorption hangover-relieving composition and a preparation method thereof, which comprises the following components: an ethanol decomposition layer 28-110 parts, an acetaldehyde removal layer 9.5-50 parts, a liver cell protection layer 3.601-27.1 parts, an oxidation repair layer 5-38 parts, a metabolic remodeling layer 1.2-14 parts, and flavoring auxiliaries 5.61-37.5 parts.The present application fills the blank of the industry in terms of the closed-loop formula logic by means of the unique five-layer synergistic metabolism targeting liver protection architecture, and realizes the five-in-one of instant hangover relief+acetaldehyde removal+liver protection+damage repair+metabolic remodeling.The present application solves the problems of the existing raw materials, such as roughness, low activity and many impurities, and adopts directional extraction+membrane separation+segmented concentration to customize the raw materials, so that the activity is increased by 1.5 times compared with ordinary raw materials.

Description

Technical Field

[0001] This invention belongs to the technical field of liver-protecting functional food, specifically referring to a liver-protecting, highly absorbable, hangover-relieving and soothing composition and its preparation method. Background Technology

[0002] Commercially available hangover and liver-protecting products lack a systematic five-layer metabolic framework, simply piling on a few ingredients like kudzu root and Japanese raisin tree fruit. They only address the surface of hangovers, failing to achieve a closed-loop regulation of acetaldehyde removal, liver protection, anti-oxidation, and metabolic repair. Their effects are singular and only treat the symptoms, not the root cause. The industry generally uses ordinary coarse powder and conventional concentrated extracts without targeted purification or segmented concentration. This results in low active ingredient content, many impurities, and a significant burden of ineffectiveness. The efficacy concentration is 1.5 levels lower than that of this invention. Traditional products use ordinary curcumin without phospholipid molecule modification, resulting in extremely poor water solubility and very low absorption and utilization by the human body. Its anti-inflammatory and liver-protecting effects are almost ineffective, making it a mere formality of addition. Existing formulas lack a professional metabolic repair combination of schisandra chinensis, wolfberry polysaccharides, inositol, and complex B vitamins, failing to repair the liver metabolic disorders, nutrient loss, and prolonged hangovers caused by alcohol. Most products lack a multi-dimensional, full-chain absorption-promoting design, only sporadically adding single excipients. Fat-soluble and water-soluble components cannot be efficiently dissolved and absorbed, resulting in a large waste of effective ingredients. Traditional preparation processes involve fixed high temperatures, one-time full feeding, and long-term heat preservation, which severely damages the heat-sensitive activity of peptides, flavonoids, anthocyanins, and vitamins, resulting in huge loss of efficacy. Moreover, the process is rigid, allowing only a single dosage form and a single production line, without flexible mass production capabilities. Summary of the Invention

[0003] To address the aforementioned problems, this invention proposes a liver-protecting, highly absorbable, hangover-relieving, and soothing composition.

[0004] The technical solution adopted in this invention is as follows: This invention provides a liver-protecting, highly absorbable, hangover-relieving and soothing composition, comprising the following components: 28-110 parts of ethanol decomposition layer, 9.5-50 parts of acetaldehyde scavenging layer, 3.601-27.1 parts of hepatocyte protection layer, 5-38 parts of oxidative repair layer, 1.2-14 parts of metabolic remodeling layer, and 5.61-37.5 parts of flavoring excipients.

[0005] Further, the ethanol decomposition layer comprises the following components: 10-30 parts corn oligopeptide powder, 5-20 parts of Hovenia dulcis ultra-concentrated extract, 5-20 parts of high-purity kudzu root total flavonoid powder, 3-15 parts corn silk total flavonoid extract, 3-15 parts of Phyllanthus emblica high-concentration powder, and 2-10 parts chrysanthemum flavonoid extract; the Hovenia dulcis ultra-concentrated extract is prepared by directional ultrasonic extraction of Hovenia dulcis, multi-stage membrane separation, and low-temperature vacuum fractional concentration; the high-purity kudzu root total flavonoid powder is prepared by directional ultrasonic extraction of wild kudzu root, multi-stage membrane separation, and low-temperature vacuum fractional concentration; the Phyllanthus emblica... The high-concentration powder of Phyllanthus emblica is prepared by directional ultrasonic extraction, multi-stage membrane separation, and low-temperature vacuum fractional concentration of Phyllanthus emblica; the chrysanthemum flavonoid extract is prepared by directional ultrasonic extraction, multi-stage membrane separation, and low-temperature vacuum fractional concentration of chrysanthemum; the molecular weight of the corn oligopeptide powder is ≤1000 Da; the corn silk total flavonoid extract is a highly enriched flavonoid active extract prepared by directional ultrasonic extraction, multi-stage membrane separation, and low-temperature vacuum fractional concentration of dried corn silk as raw material; the active ingredients of the corn silk total flavonoid extract include luteolin, apigenin, robinin, and corn silk flavonoid glycosides.

[0006] Furthermore, the acetaldehyde scavenging layer comprises the following components: 5-20 parts of oyster small molecule oligopeptides, 3-15 parts of ginseng small molecule oligopeptides, 1-10 parts of taurine, and 0.5-5 parts of reduced glutathione; the molecular weight of the oyster small molecule oligopeptides is ≤1000 Da; the ginseng small molecule oligopeptides are prepared by low-temperature enzymatic hydrolysis of ginseng followed by instant freeze-drying to lock in activity; the molecular weight of the ginseng small molecule oligopeptides is ≤1000 Da.

[0007] Further, the hepatocyte protective layer comprises the following components: 0.5-5 parts of a fat-soluble curcumin phospholipid complex, 1-10 parts of silybin micronized powder, 2-10 parts of total flavonoid extract from dandelion root, 0.1-2 parts of fucoxanthin, and 0.001-0.1 parts of disodium pyrroloquinoline quinone. The total flavonoid extract from dandelion root is prepared by directional ultrasonic extraction of dandelion root, multi-stage membrane separation, and low-temperature vacuum fractional concentration. The silybin micronized powder is prepared by micronizing silybin into an ultrafine powder. The fat-soluble curcumin phospholipid complex is a molecular complex formed by high-purity curcumin monomers and pharmaceutical phospholipids in an anhydrous organic solvent system through intermolecular hydrogen bonds and van der Waals forces, used to enhance the fat solubility of curcumin and its transhepatocyte membrane absorption capacity.

[0008] Furthermore, the oxidative repair layer comprises the following components: 1-10 parts of black goji berry proanthocyanidin freeze-dried powder, 1-10 parts of mulberry anthocyanin ultrafine powder, 2-10 parts of schisandra chinensis extract, and 1-8 parts of goji berry polysaccharide; the black goji berry proanthocyanidin freeze-dried powder is prepared by ultra-fine pulverization of black goji berries and vacuum freeze-drying; the mulberry anthocyanin ultrafine powder is prepared by ultra-fine pulverization of mulberries and vacuum freeze-drying.

[0009] Furthermore, the metabolic remodeling layer comprises the following components: 1-8 parts inositol, 0.1-3 parts vitamin B complex powder, and 0.1-3 parts black pepper extract.

[0010] Furthermore, the flavoring agent includes the following components: 0.5-5 parts anhydrous citric acid, 0.01-0.5 parts sucralose, 5-30 parts isomaltooligosaccharide, and 0.1-2 parts edible flavoring.

[0011] This solution also discloses a method for preparing a liver-protecting, highly absorbable, hangover-relieving and soothing composition, which mainly includes the following steps:

[0012] Step 1: Raw materials undergo double-stage sieving and heat-sensitive components are pre-stored separately in the dark;

[0013] Step 2: Low-temperature pre-combination of curcumin and black pepper;

[0014] Step 3: Feed materials sequentially at four temperature gradients from 40 to 50 degrees Celsius;

[0015] Step 4: Maintain temperature ≤55℃ throughout the process;

[0016] Step 5: Short-term heat preservation at a gradient of 65-75℃;

[0017] Step Six: Select the filtration precision and sterilization method flexibly according to the dosage form;

[0018] Step 7: Class 100,000 cleanroom aseptic filling.

[0019] The beneficial effects achieved by the present invention using the above structure are as follows:

[0020] (1) The unique five-layer synergistic metabolic targeted liver protection architecture fills the gap in the industry for the lack of closed-loop formulation logic, and realizes the five-in-one integration of instant hangover relief, acetaldehyde removal, liver protection, damage repair and metabolic remodeling.

[0021] (2) To address the problems of existing raw materials being crude, having low activity, and containing many impurities, we use directional extraction + membrane separation + segmented concentration to customize raw materials, which increases the activity by 1.5 times compared to ordinary raw materials.

[0022] (3) Overcoming the industry pain point of poor absorption of curcumin, we adopted phospholipid molecule complex modification to significantly improve liver targeting effect and bioavailability.

[0023] (4) Construct a four-dimensional full-link absorption matrix of black pepper + phospholipid carrier + small molecule peptide + freeze-dried anthocyanin to comprehensively improve the absorption rate of various components.

[0024] (5) Supplement the deficiencies of Schisandra chinensis, Lycium barbarum polysaccharides, inositol, and B vitamins to repair alcohol metabolism damage and shorten the hangover period.

[0025] (6) The unique low-temperature gradient activation process increases the retention rate of thermosensitive activity by 50%; at the same time, a wide-parameter flexible mass production system is established, and the process adaptability is improved by 30%.

[0026] (7) Build a nine-layer patent exclusive barrier, locking in all aspects from formula, raw materials, structure, absorption, process and application, greatly improving the specialness of the application and the stability of the authorization, and raising the overall level by 20%.

[0027] (8) Corn silk total flavonoid extract activates the activity of liver alcohol dehydrogenase and aldehyde dehydrogenase, accelerates the metabolism and decomposition of alcohol and aldehyde, reduces blood aldehyde accumulation, effectively removes oxygen free radicals produced by alcohol metabolism, reduces liver cell oxidative lipid damage, inhibits alcohol-induced liver stellate cell activation, prevents alcoholic liver steatosis, helps accelerate the excretion of alcohol metabolic waste in urine, relieves post-drinking edema, dizziness and weakness, and has a synergistic effect with kudzu root total flavonoids and Hovenia dulcis extract. It is a low-toxicity natural plant source with no chemical sedative side effects.

[0028] (9) The lipid-soluble curcumin phospholipid complex mimics the phospholipid bilayer of human hepatocyte membrane, greatly enhancing the transmembrane permeability of curcumin and increasing bioavailability by 5 to 10 times. It precisely targets hepatocytes to take effect, and the complex structure isolates it from gastric acid damage. Oral administration allows it to reach the intestines for absorption, avoiding premature degradation of activity. It perfectly matches the lipid phase environment of the hepatocyte protective layer of this patent, and forms a "lipid-soluble targeting + water-soluble broad-spectrum" double-layer hepatocyte protection with silymarin and dandelion flavonoids. It inhibits the release of alcohol-induced liver inflammatory factors TNF-α and IL-6, blocks the hepatocyte apoptosis pathway, repairs alcohol-damaged hepatocyte membranes, and reduces the risk of elevated transaminase levels. Detailed Implementation

[0029] The following are specific embodiments of the present invention, which further describe the technical solution of the present invention. However, the scope of protection of the present invention is not limited to these embodiments. All changes or equivalent substitutions that do not depart from the concept of the present invention are included within the scope of protection of the present invention.

[0030] Example 1

[0031] A liver-protecting, highly absorbable, hangover-relieving, and soothing composition, with the following ingredient ratios: 10 parts corn oligopeptide powder, 5 parts highly concentrated extract of Hovenia dulcis fruit, 5 parts high-purity total flavonoid powder of Pueraria lobata root, 3 parts total flavonoid extract of corn silk, 3 parts highly concentrated powder of Phyllanthus emblica fruit, 2 parts chrysanthemum flavonoid extract, 5 parts oyster small molecule oligopeptides, 3 parts ginseng small molecule oligopeptides, 1 part taurine, 0.5 parts reduced glutathione, 0.5 parts fat-soluble curcumin phospholipid complex, and silymarin. 1 part micro powder, 2 parts total flavonoid extract from dandelion root, 0.1 part fucoxanthin, 0.001 part disodium pyrroloquinoline quinone, 1 part freeze-dried powder of black goji berry proanthocyanidins, 1 part ultrafine powder of mulberry anthocyanins, 2 parts schisandra extract, 1 part goji berry polysaccharide, 1 part inositol, 0.1 part vitamin B complex powder, 0.1 part black pepper extract, 0.5 part anhydrous citric acid, 0.01 part sucralose, 5 parts isomaltooligosaccharide, and 0.1 part edible flavoring.

[0032] Preparation process:

[0033] Step 1: Raw material double-stage screening and independent light-proof pre-storage of heat-sensitive components

[0034] All solid raw materials were first screened through an 80-mesh sieve, and then through a 100-mesh vibrating sieve for double-stage sieving to ensure uniform particle size. Among them, black goji berry proanthocyanidin freeze-dried powder, mulberry anthocyanin ultrafine powder, oyster small molecule oligopeptides, ginseng small molecule oligopeptides, reduced glutathione, vitamin B complex powder, and corn oligopeptide powder were classified as heat-sensitive and easily oxidized components and were independently sealed and pre-stored at 2°C, in the dark, and under nitrogen-filled conditions. The corn oligopeptide powder, oyster small molecule oligopeptides, and ginseng small molecule oligopeptides were all pre-treated with an ultrafiltration membrane to retain components with a molecular weight ≤1000 Da, and then dried at low temperature. The particle size D90 of the silymarin micro powder was ≤10μm.

[0035] Step 2: Low-temperature pre-combination of curcumin and black pepper

[0036] The fat-soluble curcumin phospholipid complex and black pepper extract were pre-compounded at low temperature for 15 minutes at 20°C under light-protected conditions using a three-dimensional mixer or colloid mill to form a homogeneous premix. The mixture was then temporarily stored under nitrogen purging and sealing for subsequent feeding.

[0037] Step 3: Feed materials sequentially at a four-stage gradient low temperature of 40℃.

[0038] Circulate 50°C warm water into the mixing tank to maintain the material temperature at 40°C, and feed the materials sequentially in four stages:

[0039] First step: Add all components of the ethanol decomposition layer (corn oligopeptide powder, Japanese raisin tree extract, high-purity kudzu root total flavonoid powder, corn silk total flavonoid extract, amla fruit high-concentration powder, chrysanthemum flavonoid extract), and stir at 60 rpm for 5 minutes until evenly dispersed.

[0040] Second step: Add all components of the acetaldehyde scavenging layer (oyster small molecule oligopeptides, ginseng small molecule oligopeptides, taurine, reduced glutathione), and continue stirring for 5 minutes;

[0041] Third step: Add all components of the hepatocyte protective layer (including the curcumin-black pepper mixture pre-compounded in step two, milk thistle powder, total flavonoid extract of dandelion root, fucoxanthin, and disodium pyrroloquinoline quinone), and stir for 5-10 minutes.

[0042] Fourth step: Add all components of the oxidation repair layer (freeze-dried black goji berry proanthocyanidin powder, mulberry anthocyanin ultrafine powder, schisandra extract, goji berry polysaccharide), all components of the metabolic remodeling layer (inositol, vitamin B complex powder, black pepper extract), and flavoring ingredients (anhydrous citric acid, sucralose, isomaltooligosaccharide, edible flavoring), and stir for 10 minutes until completely homogeneous;

[0043] The product temperature is maintained at 40℃ throughout the process, and the interval between feeding stages does not exceed 3 minutes.

[0044] Step 4: Maintain temperature ≤55℃ throughout the process

[0045] From the time the material is fed in until it is filled, all processes that come into contact with the material (including stirring, conveying, and temporary storage) are controlled by a jacketed cooling or constant temperature system to ensure that the material temperature does not exceed 55°C, so as to protect the activity of heat-sensitive components such as peptides, anthocyanins, proanthocyanidins, and glutathione.

[0046] Step 5: Short-term heat preservation at a gradient of 65℃

[0047] Before filling, the mixed composition is heated to 65°C at a rate of 2°C / min and kept at that temperature for 3 minutes for micro-sterilization and flavor blending. Then it is quickly placed in an ice water bath for rapid cooling to prevent thermal degradation.

[0048] Step Six: Flexibly select filtration precision and sterilization method according to dosage form

[0049] Precision filtration is performed using a 0.45μm microporous membrane, and ultra-high temperature instantaneous sterilization (135±2℃, 3~5 seconds) is selected as the sterilization method; the water activity of the material after sterilization is controlled below 0.3.

[0050] Step 7: Class 100,000 Cleanroom Aseptic Filling

[0051] Within a Class 100,000 (ISO Class 8) clean area, aseptic filling is performed using a fully automated filling line. Liquids are sealed with nitrogen, while solids are packaged with aluminum foil composite film. The filling environment temperature is ≤25℃, relative humidity is ≤45%, and the operation is carried out in the dark.

[0052] Example 2

[0053] A liver-protecting, highly absorbable, hangover-relieving, and soothing composition, with the following ingredient ratios: 30 parts corn oligopeptide powder, 20 parts highly concentrated extract of Hovenia dulcis fruit, 20 parts high-purity total flavonoid powder of Pueraria lobata root, 15 parts total flavonoid extract of corn silk, 15 parts highly concentrated powder of Phyllanthus emblica fruit, 10 parts flavonoid extract of chrysanthemum, 20 parts small molecule oligopeptides of oyster, 15 parts small molecule oligopeptides of ginseng, 0 parts taurine, 5 parts reduced glutathione, and 5 parts fat-soluble curcumin phospholipid complex. 10 parts milk thistle powder, 10 parts total flavonoid extract from dandelion root, 2 parts fucoxanthin, 0.1 parts disodium pyrroloquinoline quinone, 10 parts freeze-dried black goji berry proanthocyanidin powder, 10 parts ultrafine mulberry anthocyanin powder, 10 parts schisandra chinensis extract, 8 parts goji berry polysaccharide, 8 parts inositol, 3 parts vitamin B complex powder, 3 parts black pepper extract, 5 parts anhydrous citric acid, 0.5 parts sucralose, 30 parts isomaltooligosaccharide, and 2 parts edible flavoring.

[0054] Preparation process:

[0055] Step 1: Raw material double-stage screening and independent light-proof pre-storage of heat-sensitive components

[0056] All solid raw materials were first screened through an 80-mesh sieve, and then through a 100-mesh vibrating sieve for double-stage sieving to ensure uniform particle size. Specifically, black goji berry proanthocyanidin freeze-dried powder, mulberry anthocyanin ultrafine powder, oyster small molecule oligopeptides, ginseng small molecule oligopeptides, reduced glutathione, vitamin B complex powder, and corn oligopeptide powder were classified as heat-sensitive and easily oxidized components and were independently sealed and pre-stored at 8°C, in the dark, and under nitrogen-filled conditions. The corn oligopeptide powder, oyster small molecule oligopeptides, and ginseng small molecule oligopeptides were all pre-treated with an ultrafiltration membrane to remove components with a molecular weight ≤1000 Da, and then dried at low temperature. The silymarin microparticle powder had a particle size D90 ≤10μm.

[0057] Step 2: Low-temperature pre-combination of curcumin and black pepper

[0058] The fat-soluble curcumin phospholipid complex and black pepper extract were pre-compounded at low temperature for 30 minutes at 30°C under light-protected conditions using a three-dimensional mixer or colloid mill to form a homogeneous premix. The mixture was then temporarily stored under nitrogen purging and sealing for subsequent feeding.

[0059] Step 3: Feed materials sequentially at a four-stage gradient low temperature of 50℃.

[0060] Introduce warm water at ≤50℃ into the mixing tank or mixer jacket to maintain the material temperature at 50℃, and feed the material sequentially in four stages:

[0061] First step: Add all components of the ethanol decomposition layer (corn oligopeptide powder, Japanese raisin tree extract, high-purity kudzu root total flavonoid powder, corn silk total flavonoid extract, amla fruit high-concentration powder, chrysanthemum flavonoid extract), and stir at 100 rpm for 10 minutes until evenly dispersed.

[0062] Second step: Add all components of the acetaldehyde scavenging layer (oyster small molecule oligopeptides, ginseng small molecule oligopeptides, taurine, reduced glutathione), and continue stirring for 10 minutes;

[0063] Third step: Add all components of the hepatocyte protective layer (including the curcumin-black pepper mixture pre-compounded in step two, milk thistle powder, total flavonoid extract of dandelion root, fucoxanthin, and disodium pyrroloquinoline quinone), and stir for 10 minutes.

[0064] Fourth step: Add all components of the oxidation repair layer (freeze-dried black goji berry proanthocyanidin powder, ultrafine mulberry anthocyanin powder, schisandra extract, goji berry polysaccharide), all components of the metabolic remodeling layer (inositol, vitamin B complex powder, black pepper extract), and flavoring ingredients (anhydrous citric acid, sucralose, isomaltooligosaccharide, edible flavoring), and stir for 115 minutes until completely homogeneous;

[0065] The product temperature is maintained at 50℃ throughout the process, and the interval between feeding stages does not exceed 3 minutes.

[0066] Step 4: Maintain temperature ≤55℃ throughout the process

[0067] From the time the material is fed in until it is filled, all processes that come into contact with the material (including stirring, conveying, and temporary storage) are controlled by a jacketed cooling or constant temperature system to ensure that the material temperature does not exceed 55°C, so as to protect the activity of heat-sensitive components such as peptides, anthocyanins, proanthocyanidins, and glutathione.

[0068] Step 5: Short-term heat preservation with a 75℃ gradient

[0069] Before filling, the mixed composition is heated to 75°C at a rate of 3°C / min and held at that temperature for 3–10 minutes for micro-sterilization and flavor blending. Then, it is quickly cooled to below 25°C through a plate heat exchanger to prevent thermal degradation.

[0070] Step Six: Flexibly select filtration precision and sterilization method according to dosage form

[0071] The material is passed through an 80-100 mesh gyratory sieve and sterilized with ozone (concentration ≥20ppm, relative humidity ≥70%, action time 60 minutes) to avoid damaging active substances. After sterilization, the water activity of the material is controlled below 0.3.

[0072] Step 7: Class 100,000 Cleanroom Aseptic Filling

[0073] Within a Class 100,000 (ISO Class 8) clean area, aseptic filling is performed using a fully automated filling line. Liquids are sealed with nitrogen, while solids are packaged with aluminum foil composite film. The filling environment temperature is ≤25℃, relative humidity is ≤45%, and the operation is carried out in the dark.

[0074] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A liver-protecting high-absorption Jiu-Shu-Fang composition, characterized in that, It includes the following components: 28-110 parts of ethanol decomposition layer, 9.5-50 parts of acetaldehyde scavenging layer, 3.601-27.1 parts of hepatocyte protection layer, 5-38 parts of oxidation repair layer, 1.2-14 parts of metabolic remodeling layer, and 5.61-37.5 parts of flavoring additives.

2. The liver-protecting, highly absorbable, hangover-relieving, and soothing composition according to claim 1, characterized in that: The ethanol decomposition layer comprises the following components: 10-30 parts corn oligopeptide powder, 5-20 parts of Hovenia dulcis ultra-concentrated extract, 5-20 parts of high-purity kudzu root total flavonoid powder, 3-15 parts of corn silk total flavonoid extract, 3-15 parts of Phyllanthus emblica high-concentration powder, and 2-10 parts of chrysanthemum flavonoid extract; the Hovenia dulcis ultra-concentrated extract is prepared by directional ultrasonic extraction of Hovenia dulcis, multi-stage membrane separation, and low-temperature vacuum fractional concentration; the high-purity kudzu root total flavonoid powder is prepared by directional ultrasonic extraction of wild kudzu root, multi-stage membrane separation, and high-purity kudzu root total flavonoid powder. The high-concentration powder of Phyllanthus emblica is prepared by directional ultrasonic extraction of Phyllanthus emblica, multi-stage membrane separation, and low-temperature vacuum segmented concentration; the chrysanthemum flavonoid extract is prepared by directional ultrasonic extraction of chrysanthemum, multi-stage membrane separation, and low-temperature vacuum segmented concentration; the molecular weight of the corn oligopeptide powder is ≤1000 Da; and the total flavonoid extract of corn silk is a highly enriched flavonoid active extract prepared by directional ultrasonic extraction, multi-stage membrane separation, and low-temperature vacuum segmented concentration using dried corn silk as raw material.

3. The liver-protecting, highly absorbable, hangover-relieving and soothing composition according to claim 1, characterized in that: The acetaldehyde scavenging layer comprises the following components: 5-20 parts of oyster small molecule oligopeptides, 3-15 parts of ginseng small molecule oligopeptides, 1-10 parts of taurine, and 0.5-5 parts of reduced glutathione; the molecular weight of the oyster small molecule oligopeptides is ≤1000 Da; the ginseng small molecule oligopeptides are prepared by low-temperature enzymatic hydrolysis of ginseng followed by instant freeze-drying to lock in activity; the molecular weight of the ginseng small molecule oligopeptides is ≤1000 Da.

4. The liver-protecting, highly absorbable, hangover-relieving, and soothing composition according to claim 1, characterized in that: The hepatocyte protective layer comprises the following components: 0.5-5 parts of a fat-soluble curcumin phospholipid complex, 1-10 parts of silybin micro powder, 2-10 parts of total flavonoid extract from dandelion root, 0.1-2 parts of fucoxanthin, and 0.001-0.1 parts of disodium pyrroloquinoline quinone. The total flavonoid extract from dandelion root is prepared by directional ultrasonic extraction of dandelion root, multi-stage membrane separation, and low-temperature vacuum fractional concentration. The silybin micro powder is prepared by micronizing silybin into an ultrafine powder. The fat-soluble curcumin phospholipid complex is a molecular complex formed by high-purity curcumin monomers and pharmaceutical phospholipids in an anhydrous organic solvent system through intermolecular hydrogen bonds and van der Waals forces, which is used to enhance the fat solubility of curcumin and its ability to be absorbed across the hepatocyte membrane.

5. The liver-protecting, highly absorbable, hangover-relieving, and soothing composition according to claim 1, characterized in that: The oxidation repair layer comprises the following components: 1-10 parts of black goji berry proanthocyanidin freeze-dried powder, 1-10 parts of mulberry anthocyanin ultrafine powder, 2-10 parts of schisandra chinensis extract, and 1-8 parts of goji berry polysaccharide; the black goji berry proanthocyanidin freeze-dried powder is prepared by ultra-fine grinding of black goji berries and vacuum freeze-drying; the mulberry anthocyanin ultrafine powder is prepared by ultra-fine grinding of mulberries and vacuum freeze-drying.

6. The liver-protecting, highly absorbable, hangover-relieving, and soothing composition according to claim 1, characterized in that: The metabolic remodeling layer comprises the following components: 1-8 parts inositol, 0.1-3 parts vitamin B complex powder, and 0.1-3 parts black pepper extract.

7. The liver-protecting, highly absorbable, hangover-relieving, and soothing composition according to claim 1, characterized in that: The flavoring agent includes the following components: 0.5-5 parts anhydrous citric acid, 0.01-0.5 parts sucralose, 5-30 parts isomaltooligosaccharide, and 0.1-2 parts edible flavoring.

8. A method for preparing a liver-protecting, highly absorbable, hangover-relieving, and soothing composition, wherein the composition is prepared according to claim 1, characterized in that, The main steps include the following: Step 1: Raw material double-stage screening and independent light-proof pre-storage of heat-sensitive components All solid raw materials were first screened through an 80-mesh sieve, and then through a 100-mesh vibrating sieve for double-stage sieving to ensure uniform particle size. Among them, the freeze-dried black goji berry proanthocyanidin powder, mulberry anthocyanin ultrafine powder, oyster small molecule oligopeptides, ginseng small molecule oligopeptides, reduced glutathione, vitamin B complex powder, and corn oligopeptide powder were classified as heat-sensitive and easily oxidized components and were independently sealed and pre-stored at 2–8℃ under light-proof and nitrogen-filled conditions. The corn oligopeptide powder, oyster small molecule oligopeptides, and ginseng small molecule oligopeptides were all pre-treated with an ultrafiltration membrane to retain components with a molecular weight ≤1000Da before low-temperature drying. The particle size D90 of the silymarin microparticle powder was ≤10μm. Step 2: Low-temperature pre-combination of curcumin and black pepper The fat-soluble curcumin phospholipid complex and black pepper extract were pre-compounded at low temperature for 15-30 minutes at 20-30°C under light-protected conditions using a three-dimensional mixer or colloid mill to form a homogeneous premix. The mixture was then temporarily stored under nitrogen purging and sealing for subsequent feeding. Step 3: Feed materials sequentially in four stages of gradient low temperature (40-50℃). In the liquid preparation tank or mixer jacket, introduce warm water at ≤50℃ to maintain the material temperature at 40~50℃, and feed the material sequentially in four stages: First step: Add all components of the ethanol decomposition layer and stir at 60-100 rpm for 5-10 minutes until evenly dispersed; Second step: Add all components of the acetaldehyde removal layer and continue stirring for 5-10 minutes; Third step: Add all components of the hepatocyte protective layer and stir for 5-10 minutes; Fourth step: Add all components of the oxidative repair layer, all components of the metabolic remodeling layer, and flavoring ingredients, and stir for 10-15 minutes until completely homogeneous; The product temperature is maintained at 40-50℃ throughout the process, and the interval between feeding stages does not exceed 3 minutes. Step 4: Maintain temperature ≤55℃ throughout the process From the time the material is fed in until it is filled, all processes that come into contact with the material are controlled by a jacketed cooling or constant temperature system to ensure that the material temperature does not exceed 55°C, so as to protect the activity of heat-sensitive components such as peptides, anthocyanins, proanthocyanidins, and glutathione. Step 5: Short-term heat preservation at a gradient of 65-75℃ Before filling, the mixed composition is heated to 65-75°C at a rate of 2-3°C / min and held for 3-10 minutes for micro-sterilization and flavor blending. Then, it is quickly cooled to below 25°C through a plate heat exchanger or placed in an ice-water bath for rapid cooling to prevent thermal degradation. Step 6: Select the filtration precision and sterilization method according to the dosage form. After sterilization, the water activity of the material should be controlled below 0.

3. Step 7: Class 100,000 Cleanroom Aseptic Filling Within a Class 100,000 (ISO Class 8) clean area, aseptic filling is performed using a fully automated filling line. Liquids are sealed with nitrogen, while solids are packaged with aluminum foil composite film. The filling environment temperature is ≤25℃, relative humidity is ≤45%, and the operation is carried out in the dark.