A traditional Chinese medicine composition for treating atopic dermatitis and application thereof

Abstract

This invention relates to the field of traditional Chinese medicine (TCM) technology, specifically to a TCM composition for treating atopic dermatitis and its application. Rehmannia glutinosa, Scrophularia ningpoensis, and Ophiopogon japonicus are the principal herbs, targeting the root cause of the disease—deficiency of Yin and blood and internal generation of deficiency heat—to nourish Yin, clear heat, generate fluids, and moisten dryness. Angelica sinensis, Paeonia lactiflora, and Polygonum multiflorum are the assistant herbs, assisting the principal herbs in nourishing blood, softening the liver, calming the mind, and unblocking the meridians. Oyster shell and mother-of-pearl are the adjuvant herbs, heavily suppressing Yang to calm the liver and extinguish wind. Moutan bark, Cicadae periostracum, and rhubarb (processed with wine) are also adjuvant herbs, clearing blood heat and dispersing wind-heat. Rhubarb (processed with wine) is particularly effective in clearing heat from the bowels and guiding heat downwards, embodying the unique treatment principle of "giving the pathogen a way out," allowing stagnant heat to be released from below and preventing the retention of pathogens. Through the synergistic effects of nourishing Yin and moistening dryness, calming the liver and suppressing Yang, and clearing heat from the bowels, the entire formula is particularly suitable for the syndrome of liver Yang hyperactivity and blood deficiency with wind-dryness, effectively relieving itching and improving skin lesions.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for treating atopic dermatitis and its application. Background Technology

[0002] Atopic dermatitis is a common, chronic, relapsing, inflammatory skin disease, clinically characterized by dry skin, intense itching, erythema, and desquamation, severely impacting patients' quality of life. The disease often recurs and is difficult to cure. Modern medicine often uses topical corticosteroids and calcineurin inhibitors for treatment, which can control symptoms in the short term, but long-term use may have side effects, and the recurrence rate is high.

[0003] In Traditional Chinese Medicine (TCM) theory, atopic dermatitis is often categorized under "wet sores" or "four-bend wind," and its pathogenesis is frequently related to yin deficiency and blood dryness, liver yang hyperactivity, and internal damp-heat. Patients often suffer from inherent intolerance, deficiency of body fluids and blood, and insufficient nourishment of the skin. Furthermore, liver stagnation transforms into fire, and wind-heat attacks the skin surface, leading to symptoms such as dry skin, persistent itching, erythema, and desquamation. While traditional TCM treatment emphasizes nourishing yin and moistening dryness, clearing heat and dispelling wind, it often lacks sufficient strength in calming the liver, suppressing yang, and guiding heat downwards, making it difficult to fundamentally quell internal wind and expel pathogenic factors.

[0004] Currently, commonly used Chinese herbal formulas in clinical practice mostly focus on clearing heat and dampness or nourishing blood and dispelling wind. For atopic dermatitis flare-ups caused by liver yang hyperactivity and internal wind, there is often a lack of targeted formulas that suppress yang and clear stagnant heat, leading to unstable efficacy and frequent symptom recurrence. Therefore, there is an urgent need for a Chinese herbal composition that can nourish yin and moisturize the skin, soothe the liver and nourish blood, as well as suppress yang and guide heat downward, to better address the core pathogenesis of this disease: "internal dampness and external dryness, and internal liver wind."

[0005] Based on the above background, this invention proposes a traditional Chinese medicine composition for the acute phase of atopic dermatitis. Through the rational combination of principal, assistant, adjuvant, and guide herbs, it emphasizes the therapeutic characteristics of sedation and heat suppression, and bowel clearing and heat purging, based on nourishing yin and clearing heat, nourishing blood and soothing the liver. It aims to address both the root cause and symptoms, relieve itching and improve skin lesions, and provide a more precise and effective prescription for the traditional Chinese medicine treatment of atopic dermatitis. Summary of the Invention

[0006] The purpose of this invention is to provide a traditional Chinese medicine composition for treating atopic dermatitis and its application, comprising Rehmannia glutinosa, Scrophularia ningpoensis, Ophiopogon japonicus, Angelica sinensis, Paeonia lactiflora, Polygonum multiflorum, Ostrea gigas, pearl powder, Paeonia suffruticosa, Cicadae periostracum, Rheum palmatum (processed with wine), and Glycyrrhiza uralensis. Through the synergistic effects of nourishing Yin and moistening dryness, calming the liver and suppressing Yang, and clearing heat from the bowels, it is particularly suitable for the syndrome of liver Yang hyperactivity and blood deficiency with wind-dryness, effectively relieving itching and improving skin lesions.

[0007] To achieve the above-mentioned technical objectives and effects, the present invention is implemented through the following technical solution: A traditional Chinese medicine composition for treating atopic dermatitis includes: Rehmannia glutinosa, Scrophularia ningpoensis, Ophiopogon japonicus, Angelica sinensis, Paeonia lactiflora, Polygonum multiflorum, Ostrea gigas, pearl powder, Paeonia suffruticosa, Cicadae periostracum, Rheum palmatum (processed with wine), and Glycyrrhiza uralensis.

[0008] Furthermore, the weight proportions of each raw material are as follows: 6-15 parts of Rehmannia glutinosa, 6-15 parts of Scrophularia ningpoensis, 6-15 parts of Ophiopogon japonicus, 6-12 parts of Angelica sinensis, 6-12 parts of Paeonia lactiflora, 9-20 parts of Polygonum multiflorum, 15-30 parts of Ostrea gigas, 15-30 parts of mother-of-pearl, 6-12 parts of Paeonia suffruticosa, 3-9 parts of Cicadae periostracum, 3-9 parts of Rheum palmatum (processed with wine), and 3-6 parts of Glycyrrhiza uralensis.

[0009] Furthermore, the weight proportions of the raw oyster and mother-of-pearl are both greater than or equal to the weight proportions of any other active pharmaceutical ingredient.

[0010] Furthermore, the weight ratio of each raw material is as follows: 10 parts Rehmannia glutinosa, 10 parts Scrophularia ningpoensis, 10 parts Ophiopogon japonicus, 9 parts Angelica sinensis, 9 parts Paeonia lactiflora, 15 parts Polygonum multiflorum, 20 parts Ostrea gigas, 20 parts Mother-of-Pearl, 9 parts Paeonia suffruticosa, 6 parts Cicadae periostracum, 6 parts Rheum palmatum (processed with wine), and 6 parts Glycyrrhiza uralensis.

[0011] Furthermore, the composition is formulated as a decoction, granules, tablets, capsules, or pills.

[0012] On the other hand, the present invention proposes a method for preparing the above-mentioned traditional Chinese medicine composition, comprising weighing each raw material according to the specified ratio, adding water and decocting, and filtering to obtain a decoction; or, extracting each raw material and mixing it with pharmaceutical excipients to prepare granules, tablets, capsules or pills.

[0013] On the other hand, the present invention proposes the application of the above-mentioned traditional Chinese medicine composition in the preparation of a medicine for treating atopic dermatitis.

[0014] The beneficial effects of this invention are: Existing prescriptions often focus on clearing heat and dampness or nourishing blood and dispelling wind. However, for the symptoms of liver yang hyperactivity and internal wind caused by yin and blood deficiency and liver malnourishment during atopic dermatitis flare-ups, they often lack direct means to suppress these symptoms, resulting in slow antipruritic effects and frequent relapses. This invention combines yin-nourishing and blood-tonifying methods, including Rehmannia glutinosa, Scrophularia ningpoensis, Ophiopogon japonicus, Angelica sinensis, and Paeonia lactiflora, with yang-suppressing and yang-taming methods, including Ostrea gigas and mother-of-pearl. It explicitly specifies that the weight of Ostrea gigas and mother-of-pearl is greater than or equal to that of any other raw material. This allows the entire prescription to replenish yin and blood while simultaneously and powerfully and directly suppressing hyperactive liver yang and calming internal liver wind through the mass-degrading properties of the herbs. This rapidly and effectively relieves the core symptom of intense itching, overcoming the shortcomings of traditional prescriptions in this regard.

[0015] This invention addresses the potential technical flaws of traditional Yin-nourishing and Yang-suppressing treatments by introducing a design that promotes bowel movement and drains heat downwards, potentially leading to stagnation of pathogenic factors. Simply nourishing Yin and using strong sedatives, if the Qi mechanism is obstructed and internal heat has no outlet, may worsen the condition or cause unstable therapeutic effects. Wine-processed rhubarb inherits the heat-clearing and turbidity-draining power of raw rhubarb, but its purgative effect is greatly reduced due to processing, avoiding the risk of excessive attack and damage to the body's vital energy. It is especially suitable for elderly or weak patients with Yin and blood deficiency. In the formula, wine-processed rhubarb works synergistically with peony bark (for cooling blood and dispersing blood stasis) and cicada slough (for dispelling wind and expelling pathogenic factors) to construct a three-dimensional clearing pathway for blood heat, wind heat, and bowel movement. This combination profoundly reflects the TCM principle of providing an outlet for pathogenic factors, ensuring that stagnant heat is resolved through multiple channels, creating a smooth internal environment for the main Yin-nourishing and Yang-suppressing drugs to exert their effects, which is key to improving the thoroughness of treatment and reducing the recurrence rate.

[0016] This invention's formulation balances the treatment of both the physical and mental aspects, as well as the directing of the medicine to the affected area, achieving comprehensive intervention for the complex clinical manifestations of atopic dermatitis. The formula not only improves the skin's dryness and scaling through yin-nourishing and blood-tonifying herbs, but also utilizes herbs such as Polygonum multiflorum vine, mother-of-pearl, and raw oyster shell to calm the mind and spirit, aiming to break the vicious cycle of itching-insomnia-nervous tension-exacerbated itching and improve accompanying sleep disorders and emotional anxiety. Simultaneously, the penetrating properties of cicada molting guide the medicine to the surface to relieve itching, while the unblocking properties of Polygonum multiflorum vine guide the medicine to the flexor surfaces of the limbs, allowing the medicinal power to precisely target the affected area. The principal herb group provides a sufficient foundation for yin nourishment; the assistant herb group provides effective support; the heavy sedative and yang-suppressing herbs are used in prominent amounts to ensure the core antipruritic efficacy; and the heat-clearing and turbidity-purging herbs are used in moderate amounts, especially rhubarb, which is controlled within a mild purgative range to avoid drastic purgation that could damage the body's vital energy. The graded and synergistic dosage configuration allows the entire formula to exert its comprehensive effects of nourishing yin and blood, calming the liver and suppressing yang, clearing heat and purging turbidity, and calming the mind and relieving itching. The effects of each medicine are distinct, orderly, and mutually reinforcing. It is especially suitable for the treatment of atopic dermatitis in the acute phase of patients with liver yang hyperactivity and blood deficiency and wind dryness according to traditional Chinese medicine diagnosis. The clinical manifestations include dry skin, severe itching, erythema, irritability, or poor sleep. The efficacy is definite.

[0017] Of course, any product implementing this invention does not necessarily need to achieve all of the advantages described above at the same time. Detailed Implementation

[0018] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Example 1

[0020] This embodiment describes a traditional Chinese medicine composition for treating atopic dermatitis, comprising: Rehmannia glutinosa, Scrophularia ningpoensis, Ophiopogon japonicus, Angelica sinensis, Paeonia lactiflora, Polygonum multiflorum, Ostrea gigas, Mother-of-pearl, Paeonia suffruticosa, Cicadae periostracum, Rheum palmatum (processed with wine), and Glycyrrhiza uralensis. Based on an understanding of the core pathogenesis of atopic dermatitis—"liver yang rising, blood deficiency and wind dryness"—Rehmannia glutinosa, Scrophularia ningpoensis, and Ophiopogon japonicus serve as the principal herbs, targeting the root cause of yin and blood deficiency and internal heat generation, exerting the effects of nourishing yin, clearing heat, generating fluids, and moistening dryness. The aim is to directly improve dryness, desquamation, and lichenification caused by insufficient skin nourishment. Angelica sinensis, Paeonia lactiflora, and Polygonum multiflorum serve as assistant herbs, assisting the principal herbs. Angelica sinensis and Paeonia lactiflora work synergistically to enhance the blood-nourishing and liver-soothing effects, nourishing the liver and moderating its function; Polygonum multiflorum focuses on nourishing the heart, calming the mind, and unblocking the meridians. Its calming effect helps relieve itching-induced irritability and insomnia, and its meridian-unblocking properties guide the medicinal effects to the extremities and skin surface. The adjuvant herbs are divided into two groups. One group consists of raw oyster shell and mother-of-pearl. These two herbs are heavy and sinking, salty and cold in nature, and primarily enter the liver meridian. In this formula, they play the role of calming the liver and suppressing yang, and sedating the mind. Their dosage is designed to directly inhibit the hyperactive liver yang and calm the internal liver wind through their sinking nature, thus becoming the key medicinal force in controlling the acute symptoms of itching. The other group of adjuvant herbs includes raw peony bark, cicada slough, and rhubarb (processed with wine). Among them, raw peony bark clears heat and cools the blood, cicada slough disperses wind-heat to relieve itching, and rhubarb (processed with wine) plays a unique role in purging stagnant heat and guiding heat downward, avoiding the stagnation that may occur with simply nourishing yin and suppressing yang, ensuring that the pathogenic heat has a channel for external release, and enhancing the thoroughness of the treatment. The guiding herb, raw licorice, is used to harmonize the cold and hot properties and ascending and descending properties of the various herbs, and to protect the spleen and stomach in the middle jiao.

[0021] To achieve stable efficacy and clarify the dose-effect relationship of the above-mentioned formulation, this embodiment further specifies the weight ratio of each raw material: 6-15 parts of Rehmannia glutinosa, 6-15 parts of Scrophularia ningpoensis, 6-15 parts of Ophiopogon japonicus, 6-12 parts of Angelica sinensis, 6-12 parts of Paeonia lactiflora, 9-20 parts of Polygonum multiflorum, 15-30 parts of Ostrea gigas, 15-30 parts of pearl powder, 6-12 parts of Paeonia suffruticosa, 3-9 parts of Cicadae periostracum, 3-9 parts of Rheum palmatum (processed with wine), and 3-6 parts of Glycyrrhiza uralensis. The dosage ranges of the principal herbs, Rehmannia glutinosa, Scrophularia ningpoensis, and Ophiopogon japonicus, are consistent, laying the foundation for the overall formula's yin-nourishing and dryness-moistening medicinal strength. The dosages of the assistant herbs, Angelica sinensis and Paeonia lactiflora, maintain a reasonable gradient with the principal herbs, ensuring effective synergy in nourishing blood. The dosages of Ostrea gigas and pearl powder are significantly higher than other herbs, reflecting the formula's principle of "suppressing yang and calming the mind," and exerting a rapid antipruritic effect. The dosage of the heat-clearing and turbidity-purging group in the adjuvant herbs, especially rhubarb processed with wine, is limited to 3-9 parts, reflecting the principle of "mild purging," aiming to clear stagnant heat rather than drastic purging, in order to suit the patient's constitution of deficiency in the root and excess in the branch. The upward shift in the dosage range of Polygonum multiflorum vine enhances its auxiliary efficacy in calming the mind and unblocking the meridians, while the minimum dosage range of raw licorice aptly positions its auxiliary role in harmonizing the various herbs.

[0022] In other embodiments, the weight ratio of each raw material is as follows: 10 parts Rehmannia glutinosa, 10 parts Scrophularia ningpoensis, 10 parts Ophiopogon japonicus, 9 parts Angelica sinensis, 9 parts Paeonia lactiflora, 15 parts Polygonum multiflorum, 20 parts Ostrea gigas, 20 parts Mother-of-Pearl, 9 parts Paeonia suffruticosa, 6 parts Cicadae periostracum, 6 parts Rheum palmatum (processed with wine), and 6 parts Glycyrrhiza uralensis. The principal herbs are in equal amounts, ensuring a balanced effect of nourishing yin and moistening dryness; the assistant herbs have sufficient effect of nourishing blood and softening the liver; the dosage of Ostrea gigas and Mother-of-Pearl, which have a strong effect of calming yang, is prominent; and the dosage of Rheum palmatum (processed with wine), which clears heat and purges turbidity, is moderate. This allows the entire formula to achieve optimal synergy in nourishing yin and blood, calming liver yang, clearing stagnant heat, and harmonizing the various herbs. Clinical trials have shown that its efficacy is particularly stable in patients with atopic dermatitis accompanied by significant itching, dry skin, and sleep disorders.

[0023] Based on the same inventive concept, namely, using the above-mentioned specific combination of medicinal materials and their weight ratio, the traditional Chinese medicine composition of this invention can be prepared into various drug dosage forms that are convenient for clinical use and storage using conventional formulation techniques in the art. For example, the medicinal materials in the specified ratio can be decocted with water and filtered to obtain a decoction. Alternatively, the effective substances in the medicinal materials can be extracted by water extraction, alcohol extraction, or other suitable methods. The obtained extract can be mixed with pharmaceutically acceptable excipients such as fillers, disintegrants, lubricants, and binders, and prepared into solid oral dosage forms such as granules, tablets, capsules, or pills according to conventional processes. These conversions between different dosage forms do not change the composition and ratio of the core active ingredients of the composition of this invention; they are merely changes in physical form to adapt to different clinical application scenarios.

[0024] The therapeutic effect of the composition of this invention stems from its rigorous formulation and dosage design, which provides a holistic intervention for the complex pathogenesis of atopic dermatitis. The principal herb group, which nourishes yin and moistens dryness, directly replenishes yin fluid to improve skin barrier function. The assistant herb group, which nourishes blood, softens the liver, calms the mind, and unblocks the meridians, not only assists the principal herb in nourishing the skin from the "blood" level, but also breaks the vicious cycle of "itching-insomnia-nervous tension-intensified itching" through its calming effect. In the adjuvant herb group, the powerful sedatives, raw oyster shell and mother-of-pearl, strongly calm the liver and subdue yang, quickly taking effect against the direct cause of itching—internal liver wind; while the heat-clearing herbs, raw peony bark, cicada slough, and rhubarb (processed with wine), clear heat from the blood and liver meridian. Among them, the purgative effect of rhubarb (processed with wine) is particularly crucial, providing an outlet for internal heat evil and preventing the heat evil from stagnating and aggravating yang hyperactivity. This allows the entire formula to have both tonifying and calming properties while also having a smoothing effect, avoiding the harm of retaining evil. The formula works synergistically to nourish yin and blood, calm the liver and suppress yang, clear heat and unblock the meridians, and soothe the mind and relieve itching. It is suitable for the treatment of atopic dermatitis of the type with hyperactivity of liver yang and deficiency of blood and dryness of wind according to traditional Chinese medicine.

[0025] Example 2

[0026] Name: Sun Moumou, Gender: Male, Age: 13 years old, Diagnosis: Atopic dermatitis, Date: First visit on 2026-01-17.

[0027] Chief complaint: Recurrent itchy papules all over the body for 6 years.

[0028] Present Illness: Six years ago, the patient developed erythema, papules, and itching on the trunk and extremities without any obvious cause. Topical medications provided some relief, but the condition worsened in hot weather. Treatment with topical tacrolimus ointment, flufenamic acid butyl ester ointment, and polysaccharide polysaccharide ointment provided some relief. An allergic reaction occurred after receiving duplerumab injections. In the past two months, the patient has developed multiple red papules on the trunk and extremities. Treatment with abuxitinib tablets 100mg orally once daily, and topical mupirocin ointment, halometasone cream, criborone ointment, and ruxolitinib ointment has not significantly improved the rash.

[0029] Specialist physical examination: Multiple brown patches ranging in size from mung beans to soybeans were found on the neck, buttocks, and groin, with occasional papules. Thickened, rough skin and lichenification were observed in the elbows and popliteal fossae. BSA 4% Auxiliary examinations: On December 30, 2025, at the Super Hospital, liver and kidney function tests, tuberculosis tests, and complete blood count were performed. Total IgE was 697 IU / mL, and the tests indicated no significant abnormalities. On January 17, 2026, at 09:17, fungal microscopy showed no abnormalities. On January 17, 2026, at 09:18, bacterial smear showed Gram-positive cocci: positive (+) / 0il. January 10, 2026, Traditional Chinese Medicine diagnosis: Dry, scaly, red papules are visible on the buttocks and abdomen, accompanied by itching. The patient prefers cold drinks. Bowel movements are dry, occurring once every two days. Urination is normal. Sleep is adequate. The tongue is red with a thick, greasy, and slippery white coating. The pulse is floating, slippery, and rapid on the right; and floating, thin, slippery, and rapid on the left at the Guan, Cun, and Chi positions. (Effective formula for atopic dermatitis) Prescription: Rehmannia glutinosa 15g, Angelica sinensis 5g, Polygonum multiflorum vine 15g, Paeonia suffruticosa 10g, Paeonia lactiflora 10g, Cicadae periostracum 6g, Glycyrrhiza uralensis 6g, Scrophularia ningpoensis 15g, Rheum palmatum 5g, Ophiopogon japonicus 30g, Ostrea gigas 30g (decoct first), Margarita 30g (decoct first); Bathing formula: Ai Da lotion + 100g Rehmannia glutinosa, 100g Scrophularia ningpoensis, 60g Scutellaria baicalensis, 60g Adenophora stricta, 15g Cnidium monnieri, 6g Mentha haplocalyx, bloodletting + Lithospermum erythrorhizon ointment + navel application; 26.1.17 Traditional Chinese Medicine Examination: Itching has lessened; patient prefers cold drinks; bowel movements are once a day (dry); urination is normal; sleep is good; tongue is red with a thin white coating; pulse is floating, slippery, and rapid on the right; pulse is floating, wiry, slippery, and rapid on the left (Guan, Cun, Chi, and Chi pulses are also floating, wiry, slippery, and rapid). (Previous prescription) Prescription: Rehmannia glutinosa 20g, Angelica sinensis 5g, Polygonum multiflorum vine 15g, Paeonia suffruticosa 10g, Paeonia lactiflora 10g, Cicadae periostracum 6g, Glycyrrhiza uralensis 6g, Scrophularia ningpoensis 20g, Rheum palmatum 5g, Ophiopogon japonicus 30g, Ostrea gigas 30g (decoct first), Margarita 30g (decoct first); Aida lotion + 60g Rehmannia glutinosa, 60g Scutellaria baicalensis, 60g Adenophora stricta, 6g Mentha haplocalyx, 30g Coptis chinensis, 30g Portulaca oleracea + apply to the navel; 26.1.24 Traditional Chinese Medicine Examination: Itching has lessened, the rash has significantly subsided, and pigmentation spots are visible. Bowel movements are once a day and are dry; urination is normal; sleep is good; tongue is red with a thin white coating that is slightly moist and slippery; pulse is floating, slippery, and rapid on the right; pulse is floating, wiry, slippery, and rapid on the left Guan position, thin, slippery, and rapid on the Cun position, and thin, slippery, and rapid on the Chi position.

[0030] Prescription: Rehmannia glutinosa 20g, Angelica sinensis 5g, Polygonum multiflorum vine 15g, Paeonia suffruticosa 10g, Paeonia lactiflora 10g, Glycyrrhiza uralensis 6g, Scrophularia ningpoensis 20g, Rheum palmatum 5g, Ophiopogon japonicus 30g, Ostrea gigas 30g (decoct first), Margarita 30g (decoct first); Comfrey ointment + navel application.

[0031] Example 3

[0032] Name: Zhang Moumou, Gender: Female, Age: 37, Diagnosis: Atopic dermatitis, urticaria. Date: First visit: January 15, 2025.

[0033] Chief complaint: Recurrent itchy papules all over the body for 1 month.

[0034] Present illness: One month ago, the patient developed erythema, papules, and itching on the trunk and extremities without any obvious cause. Topical medications provided some relief, but the condition worsened in hot weather. The patient previously used topical halometasone ointment and allantoin ointment, but the condition was not well controlled. Intramuscular injection of omalizumab was also administered, but the condition remained uncontrolled. The condition gradually worsened.

[0035] Specialist physical examination: Multiple red infiltrative patches ranging in size from mung bean to soybean are visible on the neck, back, and extensor surfaces of the limbs, with numerous red papules interspersed. The skin in the elbow crease and popliteal fossa is thickened, rough, and lichenified.

[0036] Traditional Chinese Medicine diagnosis: Newly developed erythema. On December 20th, the patient received a subcutaneous injection of omalizumab 300mg at the First Affiliated Hospital of Hainan University. Bowel movements are once a day, formed and not sticky. Urination is normal. The patient has poor sleep, often staying up late. The tongue is pale red, swollen, and greasy with a white coating. The right pulse is wiry, slippery, and rapid; the left pulse system indicates a wiry, slippery, and rapid pulse at the Guan position and a deep, slippery, and rapid pulse at the Cun and Chi positions.

[0037] Chinese herbal prescription: 20g Rehmannia glutinosa, 30g Oyster shell, 30g Pearl powder, 10g Angelica sinensis, 10g Polygonum multiflorum vine, 10g Moutan bark, 15g White peony root, 6g Cicadae periostracum, 6g Licorice root slices, 20g Scrophularia ningpoensis, 5g Rheum palmatum, 20g Ophiopogon japonicus, 5g Rheum palmatum, 10g Bupleurum chinense, 10g Scutellaria baicalensis slices. Apply 7 patches at a time, one dose per day, divided into 2 applications. January 22, 2026: No new rashes appeared. The rashes on the face, neck, and upper limbs faded and turned pigmented. Bowel movements were once a day, formed and not sticking to the diaper. Urination was normal. Sleep was easy to wake up. Sleep improved a lot after staying up late. Tongue was pale red and swollen with a white and greasy coating. Pulse was wiry, slippery, and rapid on the right. Pulse was wiry, slippery, and sour on the left. Pulse was deep and weak at the cun and chi positions.

[0038] Chinese herbal prescription: Rehmannia glutinosa 20g, Oyster shell 30g, Pearl powder 30g, Angelica sinensis 10g, Polygonum multiflorum vine 10g, Moutan bark 10g, White peony root 15g, Cicada slough 6g, Licorice root 6g, Scrophularia ningpoensis 20g, Rhubarb 5g, Bupleurum chinense 10g, Scutellaria baicalensis 10g. Apply 7 patches at a time, one dose per day, divided into 2 applications.

[0039] In summary, this invention proposes a traditional Chinese medicine composition for treating atopic dermatitis and its application. Rehmannia glutinosa, Scrophularia ningpoensis, and Ophiopogon japonicus are the principal herbs, targeting the root cause of yin and blood deficiency and internal heat generation, exerting the effects of nourishing yin, clearing heat, generating fluids, and moistening dryness. Angelica sinensis, Paeonia lactiflora, and Polygonum multiflorum are the assistant herbs, assisting the principal herbs in nourishing blood, softening the liver, calming the mind, and unblocking the meridians. Oyster shell and mother-of-pearl are the adjuvant herbs, heavily suppressing yang to calm the liver and extinguish wind. Moutan bark, Cicadae periostracum, and rhubarb (processed with wine) are the adjuvant herbs, clearing blood heat and dispersing wind-heat. Rhubarb (processed with wine) is particularly effective in clearing heat from the bowels and guiding heat downwards, embodying the unique treatment principle of "giving the pathogen a way out," allowing stagnant heat to be released from below and preventing the retention of pathogens. Through the synergistic effects of nourishing yin and moistening dryness, calming the liver and suppressing yang, and clearing heat from the bowels, the entire formula is particularly suitable for the syndrome of liver yang hyperactivity and blood deficiency with wind-dryness, effectively relieving itching and improving skin lesions.

[0040] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A traditional Chinese medicine composition for treating atopic dermatitis, characterized in that, include: Raw Rehmannia glutinosa, Scrophularia ningpoensis, raw Ophiopogon japonicus, Angelica sinensis, raw Paeonia lactiflora, Polygonum multiflorum vine, raw oyster shell, mother-of-pearl, raw Paeonia suffruticosa bark, cicada slough, wine-processed rhubarb, and raw licorice.

2. The traditional Chinese medicine composition as described in claim 1, characterized in that, The weight proportions of each raw material are as follows: 6-15 parts of Rehmannia glutinosa, 6-15 parts of Scrophularia ningpoensis, 6-15 parts of Ophiopogon japonicus, 6-12 parts of Angelica sinensis, 6-12 parts of Paeonia lactiflora, 9-20 parts of Polygonum multiflorum vine, 15-30 parts of Ostrea gigas, 15-30 parts of pearl powder, 6-12 parts of Paeonia suffruticosa, 3-9 parts of Cicadae periostracum, 3-9 parts of Rheum palmatum (processed with wine), and 3-6 parts of Glycyrrhiza uralensis.

3. The traditional Chinese medicine composition as described in claim 2, characterized in that, The weight of the raw oyster and mother-of-pearl is greater than or equal to the weight of any other raw material.

4. The traditional Chinese medicine composition as described in claim 2, characterized in that, The weight ratio of each raw material is as follows: 10 parts Rehmannia glutinosa, 10 parts Scrophularia ningpoensis, 10 parts Ophiopogon japonicus, 9 parts Angelica sinensis, 9 parts Paeonia lactiflora, 15 parts Polygonum multiflorum, 20 parts Ostrea gigas, 20 parts Mother-of-pearl, 9 parts Paeonia suffruticosa, 6 parts Cicadae periostracum, 6 parts Rheum palmatum (processed with wine), and 6 parts Glycyrrhiza uralensis.

5. The traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, The composition is formulated as a decoction, granules, tablets, capsules, or pills.

6. A method for preparing the traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, This includes weighing each of the raw materials according to the specified ratio, adding water and decocting, then filtering to obtain a decoction; or, extracting each raw material and mixing it with pharmaceutical excipients to prepare granules, tablets, capsules or pills.

7. The use of the traditional Chinese medicine composition according to any one of claims 1-4 in the preparation of a medicament for treating atopic dermatitis.