A separated type odor-removing temperature-resistant enteric-soluble health-care product and its preparation and use method

Abstract

This invention discloses a separate, odor-removing, heat-resistant enteric-coated health product and its preparation and usage methods, belonging to the technical fields of food-medicine homology health products, oral health products, and modified oral Chinese medicine preparations. The core component of this product is odor-isolating functional granules, consisting of an enteric-coated sealing layer encapsulating the functional core material. The entire product is immersed and sealed in a food-grade preservation and lubricating medium, which provides lubrication, preservation, and stability. The product can be used independently (directly orally or by steeping in hot water alone) or in conjunction with a palatable brewing base (for tea brewing). The enteric-coated sealing layer can withstand hot water steeping at 80-100℃ without cracking or leakage, dissolving only in the acidic environment of the stomach for targeted release. The preservation and lubricating medium forms a lubricating layer on the granule surface, solving the problem of throat sticking during swallowing. Through the modular design of the core granules and optional tea bags, this invention can be simultaneously adapted to multiple application scenarios, including oral health products, pharmaceuticals, individual granule brewing, and food-medicine homology tea brewing. It achieves an odor removal rate of over 98%, smooth swallowing, stable preservation, and promising industrialization prospects.

Description

Technical Field

[0001] This invention belongs to the technical field of food-medicine homology health products, oral health products, and improved oral Chinese medicine preparations. Specifically, it relates to a health product with separate odor removal, temperature-resistant enteric coating, and liquid preservation and lubrication, as well as its preparation and usage methods. In this invention, "separate" refers to a modular design where the core particles and an optional palatable base (such as a tea bag) are independently packaged and can be combined as needed. Background Technology

[0002] In the fields of medicinal and edible health products, oral health supplements, and modified oral Chinese medicine preparations, most Chinese herbs and medicinal and edible raw materials with conditioning and therapeutic effects have a bitter, astringent, or pungent taste. When used in medicinal and edible teas, the off-flavors directly infuse into the broth after being brewed with hot water, resulting in a very poor taste and severely reducing consumers' long-term compliance. When used in oral health supplements and medicines, the off-flavors can easily cause nausea and discomfort, affecting patient and user compliance.

[0003] Existing technologies address the odor problem primarily through encapsulation, microencapsulation, and droplet processing. However, these methods have the following drawbacks: the coating / matrix materials have poor heat resistance and are prone to rupture and leakage when brewed in hot water at 80 to 100°C, leading to premature release of bitterness and odor; in dry storage conditions, the particle surface is rough and easily adheres to the pharyngeal and esophageal mucosa during swallowing, causing a noticeable foreign body sensation, a feeling of being stuck, and even choking; existing technologies have not achieved a physical separation of palatability and efficacy, and cannot simultaneously meet the requirements of high-temperature brewing stability, swallowing comfort, and long-term storage.

[0004] Existing patents (such as CN120605261A) disclose taste-masking enteric-coated granule technology, but they only address the taste-masking problem of individual granules and do not involve a separate component design or a liquid immersion preservation system. Another patent (such as CN201410368629) discloses granule honey products, but honey is used as the content rather than the preservation medium, resulting in a completely different technical concept. Currently, no existing technology possesses the triple characteristics of "separate component structure + full immersion preservation in the medium + heat-resistant enteric-coated shell." Therefore, developing a health product that can simultaneously meet the needs of direct oral consumption, individual granule preparation, and tea preparation, while also being smooth to swallow and stable in preservation, has significant practical value and market potential. Summary of the Invention

[0005] The present invention aims to overcome the defects of the prior art and provide a separate, odor-removing, heat-resistant enteric-coated health care product that can be taken orally independently, brewed with hot water alone, or brewed together with a palatable base. It also solves the problems of swallowing and throat sticking in the case of direct oral administration and high-temperature leakage in the case of hot water brewing, and achieves long-term stable preservation. Technical solution

[0006] The product of this invention includes the following core components: (a) Odor-isolating granules

[0007] It consists of an enteric-coated sealing layer that encapsulates the functional core material, forming a gapless and leak-proof sealed structure.

[0008] Size limitations: Particle diameter 0.5 to 10 mm, preferably 2 to 5 mm; enteric coating thickness 0.1 to 1.0 mm, preferably 0.3 to 0.5 mm. Orthogonal experiments verified that: when the diameter is less than 2 mm, the buoyancy after being submerged in honey is too great, making it inconvenient to handle and easily leading to accidental aspiration into the airway; when the diameter is greater than 5 mm, a noticeable foreign body sensation is felt when swallowing. When the thickness is less than 0.3 mm, the breakage rate is greater than 15% when steeped in hot water above 80℃; when the thickness is greater than 0.5 mm, the enteric coating dissolution time is greater than 45 minutes, affecting the release efficacy.

[0009] Enteric-coated sealing layer material: Made of food-grade or pharmaceutical-grade heat-resistant enteric-coated material, selected from one or more compounded products of plant polysaccharides (such as sodium alginate and pectin), animal proteins (such as chitosan), and synthetic polymers (such as hydroxypropyl methylcellulose). The preferred ratio is sodium alginate:pectin:chitosan:HPMC = 3:2:3:2. The material can withstand immersion in hot water at 80 to 100°C for more than 30 minutes without cracking or leakage, and dissolves within 15 to 30 minutes in an acidic environment with a pH less than 4.5.

[0010] Core Material: Based on traditional Chinese medicine extracts, combined with 1-3% pharmaceutical-grade stabilizers (maltodextrin or xanthan gum). The traditional Chinese medicine extracts are selected from ingredients listed in the "Medicine and Food Homologous" catalogue or pharmaceutical-grade raw materials with conditioning effects and a bitter / unpleasant taste (such as dandelion, astragalus, coptis, honeysuckle, etc.), with a purity of not less than 85%. The extracts are prepared using standardized extraction processes, with an effective component retention rate of not less than 95%. (ii) Food-grade preservation and lubrication media

[0011] The granules are completely immersed and sealed in the medium. The medium is selected from at least one of honey, malt syrup, glycerin, sorbitol, edible oils, sugar alcohol aqueous solution, and aloe vera gel, with honey being preferred. The selection criteria are as follows: high osmotic pressure (2.5 to 3.0 MPa), acidic environment (pH 3.2 to 4.5), which can inhibit the growth of microorganisms and the penetration of traditional Chinese medicine extracts; good lubricity, forming a uniform lubricating layer on the surface of the granules, solving the problem of dry granules sticking to the throat; safe and palatable, meeting food and pharmaceutical excipient standards.

[0012] The preferred honey is acacia honey or jujube honey, with a moisture content of no more than 20%, a fructose + glucose content of no less than 60%, and a particle immersion depth of no less than 5mm. (iii) Optional palatable brewing base (tea bag)

[0013] This is a individually packaged brewing unit for flavorful natural ingredients (such as pressed tea bags containing a blend of red dates, goji berries, chrysanthemum, etc.), used in conjunction with the aforementioned core particles for tea brewing. Users can choose whether or not to use this base as needed.

[0014] Preparation method: Preparation of odor-isolating granules: Traditional Chinese medicine extraction (water extraction or alcohol extraction) → concentration → core material preparation → enteric material preparation → concentric dripping and embedding → solidification and shaping → quality inspection; Storage: Immerse qualified granules in a preservative lubricating medium, seal the packaging, and store at 10 to 25°C and relative humidity less than 60%.

[0015] How to use: Direct oral administration: Take the granules and swallow them whole; Brewing the granules alone: ​​Brew the granules with hot water at 80 to 100°C to obtain a broth containing the whole granules. You can drink the broth along with the granules, or remove the granules and swallow them separately (the broth can be drunk or discarded). Tea preparation: Steep the tea bag and granules together in hot water to obtain a tea infusion containing the whole granules. The infusion can be consumed along with the tea, or the granules can be removed and swallowed separately. Beneficial effects

[0016] Thorough odor isolation: Through the dual isolation of the enteric-coated sealing layer and the medium, the odor removal rate is ≥98%, and there is no odor perception whether it is taken directly or brewed with hot water.

[0017] Flexible use: The core granules can be taken orally on their own, brewed with hot water (drinking with the broth or swallowing the granules), or used in combination with tea bags, catering to a variety of user habits.

[0018] Swallowing safety: The lubricating effect of the preservative lubricating medium makes the particles smooth and non-sticky in the throat, making it especially suitable for the elderly, children and people with weak swallowing function.

[0019] Temperature stability: The enteric coating can withstand being steeped in hot water at 80 to 100℃ for more than 30 minutes without breaking, making it suitable for tea drinking and individual brewing scenarios.

[0020] Precise release: It dissolves only in the acidic environment of the stomach, avoiding premature release in the mouth and esophagus, thus improving absorption efficiency.

[0021] Stable storage: The medium immersion system prevents particle deterioration, requires no additional preservatives, and has a shelf life of not less than 12 months at room temperature.

[0022] The preparation is industrially feasible: the entire process is in GMP compliance, with complete quality control points, and can be produced on a large scale.

[0023] Save method Dry storage Honey as the main ingredient Media full immersion preservation Swallowing experience Dry, sticky throat Chew Surface lubrication, smooth Use cases Single oral As food Oral administration + brewing separately + tea Odor isolation Enteric coating none Enteric coating + media isolation + separable components Tea bag set none none Optional accessories Attached Figure Description

[0024] Figure 1 : A schematic diagram of the cross-sectional structure of the odor-isolating particles of the present invention.

[0025] Figure 2 Schematic diagram of the preservation structure of the odor-isolating granules of this invention

[0026] Figure 3 : Flowchart of the preparation process of the odor-isolating granules of the present invention.

[0027] Figure 4 : A schematic diagram of the usage process of the product of this invention.

[0028] The markings in the diagram are: 1. Sealed container, 2. Odor-isolating granules, 3. Enteric-coated sealing layer, 4. Functional core material, and 5. Preservative lubricating medium. Detailed Implementation

[0029] Example 1 (Medicinal and Edible Tea Drink) Suitable brewing base: Red dates, goji berries, and chrysanthemums mixed in a 5:3:2 ratio, 5g per packet.

[0030] Preparation of odor-isolating granules: Dandelion extract (92% purity) + 1.5% maltodextrin as the core material; enteric sealing layer material is sodium alginate: pectin: chitosan: HPMC = 3:2:3:2, concentration 6%; concentric dripping (40 drops / minute), dripped into 2.5% calcium chloride solution and solidified for 18 minutes, dried at 38℃ for 2.5 hours to obtain granules with a diameter of 3 to 4 mm and a shell thickness of 0.4 mm.

[0031] Storage: Immerse the granules in acacia honey (immersion depth 6mm), seal in a composite aluminum foil bag, and store at 20℃ and RH 55%.

[0032] Instructions for use: Steep the tea bag and granules together in 90℃ hot water for 8 minutes to obtain a brew containing whole granules. The brew can be consumed along with the brew, or the granules can be removed and swallowed separately. Results: The brew is clear and sweet with no off-taste; the granules remain intact; there is no leakage after steeping at 90℃ for 30 minutes.

[0033] Example 2 (Improved Guangdong Herbal Tea Type) Suitable brewing base: honeysuckle, chrysanthemum, prunella vulgaris, licorice, and light bamboo leaves mixed in a ratio of 3:2:2:1:2, 6g per packet.

[0034] Odor-isolating granules: Forsythia and Houttuynia cordata compound extract (purity 93%) + 2% xanthan gum as core material; outer shell as in Example 1 (concentration 5%); dripped at 35 drops / minute, solidified for 20 minutes, dried at 35℃ for 3 hours to obtain granules with a diameter of 2 to 3 mm and an outer shell thickness of 0.3 mm.

[0035] Storage: Submerge the jujube blossoms in 5mm of honey, seal in a screw-top glass jar, and store at 15℃ and 50% RH.

[0036] Instructions for use: Steep the tea bag and granules in 95℃ hot water for 10 minutes to obtain a tea containing whole granules. Drink the tea along with the tea or remove the granules and swallow them separately. Results: The herbal tea is refreshing and sweet without bitterness, and the granules do not stick to the throat.

[0037] Example 3 (Oral Medicine / Health Supplement Type) Palatable brewing base: omitted (this example only uses core particles).

[0038] Odor-isolating granules: Coptis chinensis and Astragalus membranaceus compound extract (95% purity) + 3% maltodextrin as core material; outer shell as in Example 1 (8% concentration); dripped at 45 drops / minute, solidified for 15 minutes, dried at 40℃ for 2 hours to obtain granules with a diameter of 4 to 5 mm and an outer shell thickness of 0.5 mm.

[0039] Storage: Immerse in pharmaceutical-grade honey (7mm), seal in a composite aluminum foil bag, 25℃, RH 60%.

[0040] Directions for use: When taking orally, remove the granules from the honey and swallow them whole. Results: No bad breath, extremely smooth swallowing, no sticky feeling in the throat.

[0041] Example 4 (Astragalus Granules for Solo Brewing) Palatable brewing base: omitted (this example only uses core particles).

[0042] Odor-isolating granules: Astragalus extract (93% purity, with a beany smell) + 2% maltodextrin as the core material; the outer shell is the same as in Example 1, resulting in granules with a diameter of 3 to 4 mm and an outer shell thickness of 0.4 mm.

[0043] Storage: Immerse in acacia honey (6mm) and seal in packaging.

[0044] Instructions for use: Remove the granules from the honey and steep them in 90℃ hot water for 5 minutes to obtain a broth containing intact granules. When consuming, you can drink the broth along with the granules, or use a strainer to remove the granules and swallow them separately (the broth can be drunk or discarded). Results: The broth has no beany taste, the granules are intact, and swallowing is smooth with no unpleasant odor.

[0045] Comparative Example 1 (without honey preservation) The granules from Example 1 were dried and sealed directly without being soaked in honey. After 3 months, the shells became brittle, cracked and leaked after being steeped in 80°C hot water for 5 minutes, the odor removal rate dropped to 72%, and the dried granules had a noticeable sticky feeling in the throat when swallowed directly.

[0046] Comparative Example 2 (Astragalus granules stored dry without honey) Same as Example 4, but the granules are not soaked in honey and are stored dry. When taken orally directly, the surface of the granules is rough, adheres significantly to the throat, makes swallowing difficult, and has a slight odor.

Claims

1. A separated type odor-removing temperature-resistant enteric-soluble health care product, characterized in that, The product includes odor-isolating granules and a food-grade preservative lubricant. The odor-isolating granules consist of an enteric-coated sealing layer that encapsulates the core material, forming a gapless and leak-proof sealed structure. The odor-isolating granules are completely immersed and sealed in the food-grade preservative lubricant. The food-grade preservative lubricant forms a lubricating layer on the surface of the odor-isolating granules, and after the odor-isolating granules are removed from the preservative lubricant, they remain intact and leak-free during hot water rinsing at 80-100℃.

2. The article of claim 1, wherein, It also includes palatable components used in conjunction with the odor-isolating granules, wherein the palatable components are individually packaged flavorful natural material brewing units.

3. The article of claim 2, wherein, The palatable components are individually packaged in tea bags, made of breathable non-woven fabric, and the interior is made of a mixture of sweet and odorless natural materials.

4. The article of claim 1, wherein, The diameter of the odor-isolating particles is 0.5-10 mm, and the thickness of the enteric sealing layer is 0.1-1.0 mm.

5. The article of claim 4, wherein, The diameter of the odor-isolating particles is 2-5 mm, and the thickness of the enteric sealing layer is 0.3-0.5 mm.

6. The article of claim 1, wherein The food-grade preservation and lubricating medium is selected from at least one of honey, malt syrup, glycerin, sorbitol, edible oils, sugar alcohol aqueous solution, and aloe vera gel.

7. The article of claim 6, wherein, The food-grade preservation and lubrication medium is food-grade or pharmaceutical-grade honey with a moisture content of ≤20% and a fructose + glucose content of ≥60%; the odor-isolating particles are immersed in the medium to a depth of ≥5mm.

8. The article of claim 1, wherein, The enteric sealing layer is made of food-grade or pharmaceutical-grade heat-resistant enteric material, selected from at least one of plant polysaccharide enteric materials, animal protein enteric materials, and synthetic polymer enteric materials.

9. The article of claim 1, wherein, The product is packaged in a sealed container, which is a composite aluminum foil bag or a screw-top glass jar. The odor-isolating particles are completely immersed in a preservative and lubricating medium and sealed inside the sealed container.

10. A method for preparing a separated type odor-eliminating temperature-resistant enteric-soluble health-care product, characterized in that, Includes the following steps: (1) Preparation of odor isolation granules: including Chinese medicine extraction, core material preparation, enteric sealing layer material preparation, embedding molding, curing and shaping and quality testing, to obtain granules with an enteric sealing layer encapsulating the functional core material; (2) Preservation: the granules obtained in step (1) are completely immersed in food-grade preservation and lubrication medium, packaged in sealed containers and stored under suitable conditions.

11. The method of claim 10, wherein, It also includes the preparation steps of palatable brewing base: select natural raw materials with a sweet and mild taste and no obvious odor, and sort, clean, dry, crush, mix, press and package them to make independent brewing units, which are used in conjunction with the products obtained in step (2).

12. The method of claim 10, wherein, In the herbal extraction step, the raw material is pulverized to a particle size of 80-100 mesh and dried until the moisture content is ≤10%. The extraction process uses water extraction or alcohol extraction. The water extraction temperature is 60-80℃ and the time is 2-3 hours. The alcohol extraction uses 70-80% food-grade ethanol, the temperature is 50-60℃, and the time is 1.5-2.5 hours. The concentration process uses low-temperature vacuum concentration, the temperature is ≤50℃, the vacuum degree is 0.06-0.08MPa, and the concentration is carried out until the solid content is ≥30%.

13. The preparation method according to claim 10, characterized in that, The embedding molding adopts a concentric dripping process with a dripping speed of 30-50 drops / minute and a dropper diameter of 0.8-1.0 mm. The dropper is placed in a 2-3% calcium chloride solution and solidifies for 15-20 minutes. The solidification and shaping adopts a low-temperature drying process at 35-40℃ for 2-3 hours until the moisture content of the particles is ≤5%.

14. The method of using the article according to any one of claims 1-9, characterized in that, Including at least one of the following methods: (a) direct oral administration: take out the odor isolation granules stored in the preservation lubricating medium and swallow them whole; (b) granule brewing: brew the odor isolation granules with hot water at 80-100℃ to obtain a soup containing whole granules, and take it by any of the following methods: (i) drink it together with the soup; or (ii) take out the granules and swallow them alone, and drink or discard the soup; (c) tea bag combination brewing: brew the odor isolation granules together with the individually packaged palatable brewing base at 80-100℃ to obtain a soup containing whole granules, and take it by any of the following methods: (i) drink it together with the soup; or (ii) take out the granules and swallow them alone.

15. The method of use according to claim 14, characterized in that, When the odor-isolating granules are taken orally or brewed, the preservative and lubricating medium on their surface makes them easy to swallow, does not stick to the throat, and does not release any odor in the mouth or soup.

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