Intelligent disintegration apparatus and control method for tablet detection

Abstract

The application relates to an intelligent disintegration instrument and control method for tablet detection, the disintegration instrument comprising a main body, a water tank arranged on the main body, a lifter arranged on the main body, a heating circulation module arranged in the main body and forming a loop with the water tank, a filter arranged on the loop formed by the heating circulation module and the water tank and located in front of an input end of the heating circulation module, a disintegration rack arranged on a lifting end of the lifter, a flow guide cover wrapping the disintegration rack, an image sensor arranged on the main body and facing the disintegration rack, and a controller electrically connected with the lifter, the heating circulation module and the image sensor, wherein the controller determines a disintegration end time according to a feedback image of the image sensor, and a lower end of the flow guide cover is used for sliding connection with one output end of the heating circulation module. The intelligent disintegration instrument and control method for tablet detection disclosed by the application analyze the disintegration process of the tablet by combining image analysis with an active inhibition mode, so that a more accurate disintegration time can be obtained.

Description

Technical Field

[0001] This application relates to the field of testing equipment technology, and in particular to an intelligent disintegration device and control method for tablet testing. Background Technology

[0002] A disintegration analyzer is a specialized testing instrument used in the pharmaceutical industry to detect the disintegration time of oral solid dosage forms (tablets, capsules, pills, etc.). Its core function is to simulate the human gastrointestinal environment and measure the time it takes for a drug to completely disintegrate into small particles and pass through a sieve. This is used to evaluate drug quality and in vivo release performance, and also to evaluate the consistency of oral solid dosage forms.

[0003] The specific process involves simulating the internal environment (a water bath at a constant temperature of 37℃±0.5℃ (human body temperature), with water, artificial gastric fluid (pH≈1.2), and artificial intestinal fluid (pH≈6.8) as the medium, and the basket moving up and down at a frequency of 30-32 times / minute and a stroke of 55mm±2mm) to determine the disintegration time by observation.

[0004] Conventional disintegration analyzers determine disintegration time by staff observation. This method has a certain margin of error because if the standard is that there is no drug residue, the obtained disintegration time will be later than the actual disintegration time. If a certain time in the intermediate process is used as the disintegration time, the evaluation criteria will be inconsistent due to the inconsistency of standards.

[0005] Currently, there are explorations into using AI recognition methods for analysis, but due to the difficulty in recognition caused by the turbidity during the drug disintegration process and the impact of the testing process caused by the extraction method used for observation, it is still difficult to determine the accurate disintegration time. Summary of the Invention

[0006] This application provides an intelligent disintegration analyzer and control method for tablet detection, which analyzes the tablet disintegration process by combining active inhibition with image analysis to obtain a more accurate disintegration time.

[0007] The above-mentioned objective of this application is achieved through the following technical solution: In a first aspect, this application provides an intelligent disintegration device for tablet detection, comprising: main body; The water tank is located on the main body; The lifting device is located on the main body. The lifting end of the lifting device performs reciprocating linear motion in the vertical direction and can extend into the water tank. The heating circulation module is located inside the main body and forms a loop with the water tank; The filter is installed in the loop formed by the heating circulation module and the water tank and is located in front of the input end of the heating circulation module; The disintegration platform is located on the lifting end of the elevator; The flow guide is wrapped around the disintegration platform. The lower end of the flow guide is used to slide and connect with one output end of the heating circulation module, and the upper end of the flow guide is an open end. An image sensor is mounted on the main body and faces the disintegration platform; The controller is electrically connected to the lift, heating circulation module, and image sensor. The controller determines the disintegration end time based on the feedback image from the image sensor.

[0008] In one possible implementation of the first aspect, the disintegration test bench includes: The suspension rod is detachably and fixedly connected to the lifting end of the lifting device; The disintegration platform is located on the suspension rod; Multiple disintegration chambers are evenly distributed on the disintegration platform. The upper end of each disintegration chamber is open, and the lower end of each disintegration chamber is equipped with a first filter screen.

[0009] One possible implementation of the first aspect also includes: A rotating baffle is mounted on the disintegration platform and rotatably connected to the disintegration platform. Multiple through holes are evenly distributed on the rotating baffle; Multiple secondary filters are evenly distributed on the rotating baffle; The actuator is mounted on the suspension rod and connected to the disintegration platform; The number of through holes corresponds to the number of disintegration chambers, and the number of second filters corresponds to the number of disintegration chambers.

[0010] In one possible implementation of the first aspect, the fairing includes: The inner cover and the outer cover are located inside the outer cover. The inner cover is fixedly connected to the disintegration platform. There is an annular flow channel between the inner cover and the outer cover. The input channel is connected to the outer cover and communicates with the annular flow channel. The input channel is used to slide to one of the output ends of the heating circulation module. The output channel has one end that passes through the outer cover and connects to the inner cover, and the other end that is slidably connected to one input end of the heating cycle module. The anti-flow ring has its first end connected to the outer cover and its second end extending into the inner cover.

[0011] In one possible implementation of the first aspect, the influence range of the backflow ring is annular in shape.

[0012] In one possible implementation of the first aspect, the controller determines the disintegration end time based on the feedback image from the image sensor, including: The images generated during the decomposition process are used to obtain the base image; The base image is cropped to retain only the disintegration chamber portion, resulting in the analysis image. Identify and analyze granular objects in the image and determine the volume of the granular objects; The particles are grouped according to their screening diameter to obtain qualified and unqualified groups; The particle objects are repeatedly grouped in the time series until there are no particle objects in the unqualified group; The time when the analysis image is generated when there are no particle objects in the non-compliant group is taken as the disintegration end time.

[0013] In one possible implementation of the first aspect, after determining the volume of the particle object, it further includes: Determine the edge contour of the particle object, and denote it as the first edge contour; Drive the particle object to move in the horizontal direction to obtain the second edge contour of the particle object; By comparing the first edge contour and the second edge contour, the true edge contour of the particle object is obtained.

[0014] One possible implementation of the first aspect also includes: The true edge contours of the particle objects are continuously acquired over time. Draw an area change curve based on the real edge contour of the continuously acquired particle object; The curve of change in area is segmented according to the changing trend of the curve of change in area. The true edge contour of the particle object is determined based on the segmentation processing results.

[0015] In one possible implementation of the first aspect, the segmented processing result of the change curve includes a single result and multiple results, where a single result indicates that the particle object is a single particle object, and multiple results indicate that the particle object is multiple overlapping particle objects.

[0016] Secondly, this application provides a control method for an intelligent disintegrator for tablet testing, using the intelligent disintegrator for tablet testing as described in the first aspect and any implementation thereof, comprising: The tablet is placed on the disintegration platform and driven into the inside of the flow guide; Pour the required amount of liquid, which must be at the correct temperature, into the water tank. The heating circulation module works to drive the liquid in the water tank and the liquid in the flow guide to circulate; The image sensor acquires images of tablets on the disintegration stand to obtain feedback images; The feedback images were analyzed to determine the disintegration end time of the tablets. Attached Figure Description

[0017] Figure 1 This is a front view of an intelligent disintegrator for tablet testing provided in this application.

[0018] Figure 2 This is a structural schematic diagram of a heating circulation module provided in this application.

[0019] Figure 3 This is a structural schematic diagram of a lifting device and a disintegration platform provided in this application.

[0020] Figure 4 This is a schematic diagram illustrating the working principle of a heating circulation module provided in this application.

[0021] Figure 5 This is a schematic diagram illustrating the working principle of another heating circulation module provided in this application.

[0022] Figure 6 This is a structural schematic diagram of a disintegration platform provided in this application.

[0023] Figure 7 This is a structural schematic diagram of a rotating baffle provided in this application.

[0024] Figure 8 This is a schematic diagram showing the relative positions of a disintegration platform and a rotating baffle provided in this application.

[0025] Figure 9 This is a schematic diagram showing the relative positions of another disintegration platform and rotating baffle provided in this application.

[0026] Figure 10 This is a structural schematic diagram of a fairing provided in this application.

[0027] Figure 11 This is a schematic diagram of the flow path of liquid inside a flow guide provided in this application.

[0028] Figure 12 This is a schematic diagram illustrating the process by which a controller, as provided in this application, determines the disintegration end time based on feedback images from an image sensor.

[0029] Figure 13 This is a schematic diagram of overlapping particle objects provided in this application.

[0030] Figure 14 This is a schematic diagram illustrating the process of overlapping and disappearing of particle objects provided in this application.

[0031] Figure 15 This is an area change curve provided in this application.

[0032] Figure 16 This is another area change curve provided in this application.

[0033] Figure 17 This is a schematic block diagram of the connectivity of a controller provided in this application.

[0034] In the diagram, 1. Main body, 2. Water tank, 3. Lifter, 4. Heating circulation module, 5. Filter, 6. Disintegration platform, 7. Flow guide, 8. Image sensor, 9. Controller, 61. Suspension rod, 62. Disintegration platform, 63. Disintegration chamber, 64. First filter screen, 65. Rotating baffle, 66. Through hole, 67. Second filter screen, 68. Driver, 71. Inner cover, 72. Outer cover, 73. Input channel, 74. Output channel, 75. Anti-flow ring. Detailed Implementation

[0035] The technical solutions in this application will be further described in detail below with reference to the accompanying drawings.

[0036] This application discloses an intelligent disintegrator for tablet testing. In some examples, the intelligent disintegrator for tablet testing disclosed in this application includes a main body 1, a water tank 2, a lifting device 3, a heating circulation module 4, a filter 5, a disintegration platform 6, a flow guide 7, an image sensor 8, and a controller 9. Specifically, the water tank 2 is mounted on the main body 1. Figure 1 As shown, its function is to provide a stable ambient temperature, which is generally required to be 37℃±0.5℃. The liquid in water tank 2 is water, artificial gastric juice, or artificial intestinal juice.

[0037] When using, first add sufficient liquid to water tank 2 and heat the liquid to the specified temperature. There is no specific limit to the specified temperature; it is determined based on the tablets, liquid, and specific test requirements.

[0038] Please see Figure 2 The heating circulation module 4 is located inside the main body 1 and consists of four parts: heater, circulation pump, pipe and temperature sensor. The heater, circulation pump and pipe and water tank 2 form a loop. The heater is responsible for heating the liquid, the circulation pump is responsible for driving the liquid to circulate, and the temperature sensor is responsible for detecting the liquid temperature.

[0039] In some possible implementations, the temperature sensor is located inside the water tank 2 and at the outlet of the heater.

[0040] Please see Figure 3The lifting device 3 is installed on the main body 1 (inside). The lifting end of the lifting device 3 reciprocates in a straight line in the vertical direction and can extend into the water tank 2. The lifting device 3 has two functions: first, to remove the disintegration platform 6 from the water tank 2 and put the disintegration platform 6 into the water tank 2 to assist in placing tablets; second, to simulate the impact generated by the peristalsis of tablets in the human body.

[0041] In some possible implementations, the lift 3 includes an electric lift located within the main body 1 and a crossbeam connected to the electric lift, the crossbeam being responsible for securing the disintegration platform 6.

[0042] The filter 5 is located in the loop formed by the heating circulation module 4 and the water tank 2 and is located in front of the input end of the heating circulation module 4. Its function is to filter solid substances in the liquid.

[0043] It should be noted here that the heating circulation module 4 in this application provides two circulation paths. The first circulation path circulates the liquid in the water tank 2 for the purpose of heating and heat preservation. Figure 4 As shown, the second path circulates the liquid within the flow deflector 7, aiming to suppress the irregular movement of solid matter within the flow deflector 7, such as... Figure 5 As shown.

[0044] Figure 4 and Figure 5 The dotted lines in the diagram indicate that some of the pipes are located inside the base below water tank 2. The advantage of this structure is that it prevents these pipes from being exposed to the air, improving integration and avoiding damage from impacts caused by exposed pipe packages.

[0045] In light of the issues mentioned in the background section, turbidity during drug disintegration can lead to difficulties in identification. When the liquid inside the flow deflector 7 is in a flowing (unidirectional) state, this turbidity can be effectively suppressed, thus not affecting the normal operation of the image sensor 8.

[0046] like Figure 1 As shown, the image sensor 8 is mounted on the main body 1 and faces the disintegration platform 6. Its function is to photograph the disintegration of the tablets on the disintegration platform 6. The controller 9 is electrically connected to the lift 3, the heating circulation module 4 and the image sensor 8. Its function is to complete the disintegration test process described above.

[0047] In some possible implementations, each disintegration test 6 is equipped with an image sensor 8.

[0048] Please see Figure 17The controller 9 is electrically connected to the heating circulation module 4, the lift 3, the driver 68, and the image sensor 8. The circulation pump, heater, and control valve located on the pipeline in the heating circulation module 4 need to be controlled. The temperature sensor is responsible for feeding back temperature data. The core of the lift 3 and the driver 68 is the motor, which needs to be controlled. The image fed back by the image sensor 8 needs to be analyzed.

[0049] Based on this, the core of controller 9 uses a microcontroller (such as the STM32 series) or PLC as the main control chip, responsible for receiving data from each module, outputting control commands, and coordinating the orderly operation of each functional module. It is the central hub of the entire control logic. At the same time, an FPGA (Xilinx Artix-7) ARM Cortex-A series processor (ARM Cortex-A9) is used for image analysis.

[0050] In some examples, please refer to Figure 6 and Figure 7 The disintegration platform 6 includes a suspension rod 61, a disintegration platform 62, a disintegration chamber 63, and a first filter screen 64. The suspension rod 61 is detachably and fixedly connected to the lifting end of the lifting device 3, for example, by using bolts for fixed connection. The disintegration platform 62 is fixed on the suspension rod 61.

[0051] Multiple disintegration chambers 63 are evenly distributed on the disintegration platform 62. These disintegration chambers 63 are evenly arranged around the suspension rod 61. The upper end of the disintegration chamber 63 is an open end, and the lower end of the disintegration chamber 63 is provided with a first filter screen 64. The tablet is placed on the first filter screen 64. In the subsequent disintegration process, the fragments generated during the tablet disintegration process (particle size smaller than the filter diameter of the first filter screen 64) will pass through the first filter screen 64.

[0052] For some possible implementations, please refer to Figures 8 to 9 Furthermore, a rotating baffle 65 is added, which is rotatably connected to the disintegration platform 62. There are multiple through holes 66 and second filters 67, all of which are set on the rotating baffle 65. The number of through holes 66 and second filters 67 is the same as the number of disintegration chambers 63 and corresponds one-to-one.

[0053] When the through hole 66 moves to the upper end of the disintegration chamber 63, the upper end of the disintegration chamber 63 is open; when the second filter 67 moves to the upper end of the disintegration chamber 63, the upper end of the disintegration chamber 63 is closed by the second filter 67. At this time, both the upper and lower ends of the disintegration chamber 63 are blocked by the filter, which simulates the impact of the tablet in a real scene.

[0054] In some possible implementations, such as Figure 3As shown, an actuator 68 has been added. The function of the actuator 68 is to drive the disintegration platform 62 to rotate, and its function will be described later. The specific way to drive the disintegration platform 62 to rotate is that a sleeve is set on the disintegration platform 62. There is a gap between the sleeve and the suspension rod 61, that is, the two do not contact each other. The actuator 68 is connected to the sleeve through a friction pair or a gear pair to drive the disintegration platform 62 to rotate.

[0055] To illustrate with a specific scenario, a tablet is placed on the first filter 64 and moves back and forth in a straight line in the vertical direction. When the first filter 64 moves slowly, the tablet can remain stable on the first filter 64. However, when the first filter 64 moves faster, the second filter 67 is needed to intercept it.

[0056] In addition, when a simulated impact is required, a second filter 67 is also needed for interception.

[0057] In some examples, such as Figure 10 and Figure 11 As shown, the flow guide 7 includes an inner shroud 71, an outer shroud 72, an input channel 73, an output channel 74, and a backflow ring 75. Specifically, the inner shroud 71 is located inside the outer shroud 72. The inner shroud 71 is fixedly connected to the disintegration platform 6. There is an annular flow guide channel between the inner shroud 71 and the outer shroud 72, which supplies liquid flow.

[0058] The input channel 73 is connected to the outer cover 72 and communicates with the annular guide channel. The input channel 73 is used to slide to one of the output ends of the heating circulation module 4, so that the liquid flowing out from one of the output ends of the heating circulation module 4 can continuously flow into the annular guide channel.

[0059] The first end of the output channel 74 passes through the outer cover 72 and connects to the inner cover 71. The second end is used to slide to connect with one input end of the heating circulation module 4, so that the liquid in the inner cover 71 can return directly to the heating circulation module 4.

[0060] The first end of the anti-flow ring 75 is connected to the outer cover 72, and the second end extends into the inner cover 71. Its function is to guide the liquid in the annular guide channel into the inner cover 71. Taking the actual placement position as an example, the liquid in the annular guide channel flows from bottom to top, while the liquid in the inner cover 71 flows from top to bottom. This method keeps the flow direction of the liquid in the inner cover 71 unchanged.

[0061] In some possible implementations, the influence range of the reflux ring 75 is annular in shape, with the aim of preventing the liquids flowing out of the reflux ring 75 from interfering with each other.

[0062] Please see Figure 12 The controller 9 determines the disintegration end time based on the feedback image from the image sensor 8 in the following specific way: S101, Obtain the image generated during the decomposition process to obtain the base image; S102, crop the base image, retaining only the disintegration chamber portion of the base image to obtain the analysis image; S103, Identify and analyze the particle objects included in the image and determine the volume of the particle objects; S104, group the particle objects according to the screening diameter to obtain qualified group and unqualified group; S105, Repeatedly group the particle objects in the time series until there are no particle objects in the unqualified group; S106, the time when the analysis image is generated when there are no particulate objects in the non-conforming group is taken as the disintegration end time.

[0063] In steps S101 to S106, the image (base image) generated during the decomposition process is first acquired, and then the base image is cropped to retain only the disintegration chamber portion of the base image to obtain the analysis image. Here, an identification ring can be added at the edge of the disintegration chamber 63. The color of the identification ring is clearly different from the color of the disintegration stage 62, that is, the base image can be cropped directly through the identification ring during the cropping process.

[0064] Next, the particle objects included in the image are identified and analyzed, and their volumes are determined. The specific method is as follows: Denoising and Enhancement: The image is processed with noise filtering and image enhancement to ensure a clean background and highlight the outlines of tablets and granules.

[0065] Grayscale conversion: Converting a color image (RGB) to a grayscale image in order to identify edges by grayscale differences.

[0066] The method of inter-frame difference (detecting moving objects) is combined with semantic segmentation algorithms (such as GrabCut algorithm) to distinguish between foreground (particles) and background (liquid).

[0067] Through corrosion and expansion operations, the broken edges are connected, the voids inside the particles are filled, and a complete particle outline is formed.

[0068] The resulting particle outlines are used as particle objects.

[0069] Calculating the volume of a particle object requires considering both the area of ​​the particle object on the analysis image and the distance between the disintegration stage 62 and the image sensor 8. The specific process is as follows: Acquiring distance D: The system reads real-time distance data between the disintegration stage 62 and the image sensor 8, which is usually determined by a displacement sensor or a preset mechanical position; Calculate the magnification M: Based on the lens focal length F and object distance D, calculate the optical magnification. The formula is approximately: M≈F / (DF). Calculate the actual physical length represented by each pixel: K = P / M, where P is the pixel size of the sensor; Calculate the actual projected area of ​​the particle: A real =NxK 2 N is the number of pixels.

[0070] The equivalent diameter is derived using the following formula: ; Assuming the particle is a sphere, the volume can be calculated using the following formula: .

[0071] Next, the particles are grouped according to their screening diameter to obtain qualified and unqualified groups. The screening diameter here is a fixed value, usually 2mm. That is, particles with a diameter greater than or equal to 2mm are classified into the unqualified group, and particles with a diameter less than 2mm are classified into the qualified group.

[0072] Particles in the acceptable group will be carried away from the disintegration chamber 63 by the unidirectional flow of liquid, and these particles will disappear from the analysis image, but this requires a process. In this application, the image sensor 8 works continuously, that is, it repeatedly groups the particles in a time series until there are no particles in the unacceptable group. Finally, the time when there are no particles in the unacceptable group is the generation time of the analysis image, which is then taken as the disintegration end time.

[0073] The criteria for determining disintegration are as follows: Disintegration refers to the process by which a solid dosage form dissolves into fine particles in a liquid medium. "Complete disintegration" does not require the complete dissolution of the active pharmaceutical ingredient. Specifically, it means that the test sample completely disintegrates or dissolves into fragments that can pass through the first filter screen 64. In other words, the disintegration process is considered complete when the existing fragments can pass through the first filter screen 64, rather than when the disintegration chamber 63 is emptied. This is a practical difficulty for manual identification.

[0074] Even after determining the volume of the particle objects, there is still a problem of recognition difficulties caused by overlapping particle objects, such as... Figure 13 As shown, the specific reason is that the analysis image obtained in this application is a two-dimensional image and does not display height information. If two particle objects overlap, it will lead to misjudgment. To solve this problem, the following method is used: Determine the edge contour of the particle object, and denote it as the first edge contour; Drive the particle object to move in the horizontal direction to obtain the second edge contour of the particle object; By comparing the first edge contour and the second edge contour, the true edge contour of the particle object is obtained.

[0075] Here, the particle object is driven to move horizontally, such as... Figure 14 As shown, this refers to the disintegration platform 62 rotating or oscillating a small distance under the drive of the driver 68. At this time, the liquid inside the disintegration platform 62 is shaken. The edge contour of the particle object before shaking is recorded as the first edge contour, and the edge contour of the particle object after shaking is recorded as the second edge contour.

[0076] By comparing the first and second edge contours, the true edge contour of the particle object can be obtained, and then the following method is used for determination: The true edge contours of the particle objects are continuously acquired over time. Draw an area change curve based on the real edge contour of the continuously acquired particle object; The curve of change in area is segmented according to the changing trend of the curve of change in area. The true edge contour of the particle object is determined based on the segmentation processing results.

[0077] This method records the changes in the actual edge contour (length) over time, resulting in an area change curve. Figure 15 and Figure 16 After (as shown), the curve will be segmented according to the trend of the area change curve, resulting in the following two situations: The segmented processing result of the change curve includes one segment of the result ( Figure 15 ) and multi-segment results ( Figure 16 A single result indicates that the particle object is a single particle object, while multiple results indicate that the particle object is multiple overlapping particle objects.

[0078] This allows us to determine the true edge contour of the particle object.

[0079] In some possible implementations, the basis for segmented processing is that the area of ​​the particle object decreases by more than 5% to 15%. If the particle size is small (<1mm), the density is low, or the sloshing amplitude of the disintegration liquid is small, the decrease can be taken as the lower limit (5% to 8%) to avoid missing overlapping particles; if the particle size is large (>5mm), the density is high, or the sloshing amplitude of the disintegration liquid is large, the decrease can be taken as the upper limit (10% to 15%) to avoid misjudging the normal fluctuation of individual particles.

[0080] Specifically, if two particle objects overlap, the distance between them will change when the liquid in the disintegration platform 62 is shaken, and the overlapping area may even disappear, at which point the area of ​​the particle objects will change.

[0081] If there is only one particle object, the area of ​​this particle object will fluctuate, but it will always remain within a certain range. From the area change curve, there is only one fixed range on the area change curve of a single particle object, but two particle objects will have two fixed ranges.

[0082] This application also provides a control method for an intelligent disintegration analyzer used for tablet testing, the specific steps of which are as follows: The tablet is placed on the disintegration platform 6 and the disintegration platform 6 is driven into the inside of the flow guide 7; Pour the required amount of liquid, which must be at the required temperature, into water tank 2; The heating circulation module 4 operates, driving the liquid in the water tank 2 and the liquid in the guide shroud 7 to circulate; The image sensor 8 acquires an image of the tablets on the disintegration stand 6 to obtain a feedback image; The feedback images were analyzed to determine the disintegration end time of the tablets.

[0083] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A smart disintegration analyzer for tablet detection, characterized in that, include: Main body (1); Water tank (2) is located on the main body (1); The lifting device (3) is installed on the main body (1). The lifting end of the lifting device (3) performs reciprocating linear motion in the vertical direction and the lifting end of the lifting device (3) can extend into the water tank (2). The heating circulation module (4) is located inside the main body (1) and forms a loop with the water tank (2); The filter (5) is located in front of the input end of the heating circulation module (4) and the water tank (2) in the loop formed by the heating circulation module (4); The disintegration platform (6) is located on the lifting end of the elevator (3); The flow guide (7) is wrapped on the disintegration platform (6). The lower end of the flow guide (7) is used to slide and connect with one output end of the heating cycle module (4). The upper end of the flow guide (7) is an open end. An image sensor (8) is mounted on the main body (1) and faces the disintegration platform (6). The controller (9) is electrically connected to the lift (3), the heating circulation module (4), and the image sensor (8); The controller (9) determines the disintegration end time based on the feedback image from the image sensor (8); The fairing (7) includes: The inner cover (71) and the outer cover (72) are located inside the outer cover (72). The inner cover (71) is fixedly connected to the disintegration platform (6). There is an annular flow channel between the inner cover (71) and the outer cover (72). The input channel (73) is connected to the outer cover (72) and communicates with the annular guide channel. The input channel (73) is used to slide to one of the output ends of the heating circulation module (4). The output channel (74) has its first end passing through the outer cover (72) and connecting to the inner cover (71), and its second end is used to slide to connect with one input end of the heating cycle module (4); The anti-flow ring (75) has its first end connected to the outer cover (72) and its second end extending into the interior of the inner cover (71); The shape of the influence range of the anti-flow ring (75) is annular.

2. The intelligent disintegration analyzer for tablet detection according to claim 1, characterized in that, The disintegration test bench (6) includes: The suspension rod (61) is detachably and fixedly connected to the lifting end of the lifting device (3); The disintegration platform (62) is located on the suspension rod (61); Multiple disintegration chambers (63) are evenly distributed on the disintegration platform (62). The upper end of the disintegration chamber (63) is an open end, and the lower end of the disintegration chamber (63) is provided with a first filter screen (64).

3. The intelligent disintegration analyzer for tablet detection according to claim 2, characterized in that, Also includes: A rotating baffle (65) is provided on the disintegration platform (62) and is rotatably connected to the disintegration platform (62); Multiple through holes (66) are evenly distributed on the rotating baffle (65); Multiple second filters (67) are evenly distributed on the rotating baffle (65); A drive (68) is mounted on a suspension rod (61) and connected to a disintegration platform (62); The number of through holes (66) is the same as the number of disintegration chambers (63) and they correspond one-to-one. The number of second filter screens (67) is the same as the number of disintegration chambers (63) and they correspond one-to-one.

4. The intelligent disintegration analyzer for tablet detection according to claim 1, characterized in that, The controller (9) determines the disintegration end time based on the feedback image from the image sensor (8), including: The images generated during the decomposition process are used to obtain the base image; The base image is cropped to retain only the disintegration chamber portion, resulting in the analysis image. Identify and analyze granular objects in the image and determine the volume of the granular objects; The particles are grouped according to their screening diameter to obtain qualified and unqualified groups; The particle objects are repeatedly grouped in the time series until there are no particle objects in the unqualified group; The time when the analysis image is generated when there are no particle objects in the non-compliant group is taken as the disintegration end time.

5. The intelligent disintegration analyzer for tablet detection according to claim 4, characterized in that, After determining the volume of the particle object, the following is also included: Determine the edge contour of the particle object, and denote it as the first edge contour; Drive the particle object to move in the horizontal direction to obtain the second edge contour of the particle object; By comparing the first edge contour and the second edge contour, the true edge contour of the particle object is obtained.

6. The intelligent disintegration analyzer for tablet detection according to claim 4, characterized in that, Also includes: The true edge contours of the particle objects are continuously acquired over time. Draw an area change curve based on the real edge contour of the continuously acquired particle object; The curve of change in area is segmented according to the changing trend of the curve of change in area. The true edge contour of the particle object is determined based on the segmentation processing results.

7. The intelligent disintegration analyzer for tablet detection according to claim 6, characterized in that, The segmented processing results of the change curve include a single-segment result and a multi-segment result. A single-segment result indicates that the particle object is a single particle object, while a multi-segment result indicates that the particle object is multiple overlapping particle objects.

8. A control method for an intelligent disintegrator for tablet testing, using the intelligent disintegrator for tablet testing as described in any one of claims 1 to 7, characterized in that, include: The tablet is placed on the disintegration platform (6) and driven into the interior of the flow guide (7); Pour the required amount of liquid, which must be measured and at the required temperature, into the water tank (2); The heating circulation module (4) works to drive the liquid in the water tank (2) and the liquid in the guide shroud (7) to circulate; The image sensor (8) acquires an image of the tablet on the disintegration stand (6) to obtain a feedback image; The feedback images were analyzed to determine the disintegration end time of the tablets.

Images