A soothing, repairing and whitening composition for sensitive skin and applications thereof

Abstract

The present application relates to a soothing, repairing and whitening composition for sensitive skin and its application, belonging to the technical field of cosmetics. The composition comprises the following components in parts by weight: 2-5 parts of Lomentaria alata extract, 1-3 parts of Prunus serrulata flower extract, 1-3 parts of crocus sativus flower extract, 0.5-1 part of bordeaux tree leaf extract, and 0.5-2 parts of glucosyl hesperidin. The composition provided by the present application provides a high-efficiency and safe soothing, repairing and whitening solution for sensitive skin through multiple pathways such as antioxidation, repair and moisture retention, anti-inflammatory stability maintenance and promotion of microcirculation, and has significant application value and market prospect.

Description

Technical Field

[0001] This invention relates to the technical field of cosmetics, specifically to a soothing, repairing, and whitening composition for sensitive skin and its application. Background Technology

[0002] Sensitive skin, due to impaired skin barrier function, increased neurovascular reactivity, and active immune inflammatory responses, exhibits symptoms such as irritation, redness, stinging, and burning, severely limiting the choice of skincare products. Whitening is one of the core skincare demands of Asian consumers, and the need for whitening is particularly urgent yet difficult to meet among those with sensitive skin. Traditional whitening products mainly achieve their effects through single pathways such as inhibiting tyrosinase activity, blocking melanin transport, or accelerating keratin metabolism. Common active ingredients such as high-concentration vitamin C, kojic acid, and niacinamide, while possessing certain whitening effects, are often accompanied by irritation. For sensitive skin with a fragile barrier, these ingredients can easily trigger inflammatory reactions, leading to a vicious cycle of "the more you whiten, the more sensitive you become," and even inducing post-inflammatory hyperpigmentation (PIH), which further worsens dull skin tone.

[0003] Therefore, developing a composition that can effectively inhibit melanin production, provide anti-inflammatory and stabilizing effects throughout the skin process, and repair the skin barrier is of great significance for meeting the safe whitening needs of sensitive skin. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a soothing, repairing, and whitening composition for sensitive skin and its application.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides a soothing, repairing and whitening composition for sensitive skin, comprising the following components in parts by weight: 2-5 parts of *Lithocarpus septemlobus* extract, 1-3 parts of *Prunus serrulata* flower extract, 1-3 parts of *Saffron crocus* flower extract, 0.5-1 part of *Bordeaux* leaf extract, and 0.5-2 parts of glucosyl hesperidin.

[0006] Lithops spurii extract: Lithops spurii extract is a natural ingredient obtained from calcareous red algae, rich in minerals and trace elements such as calcium and magnesium. In skincare and cosmetics, it is mainly used as a moisturizer and soothing agent, helping the skin retain moisture, strengthening the skin barrier function, and reducing dryness and tightness. It also has gentle soothing properties, relieving skin irritation and redness, making it suitable for sensitive skin. Furthermore, this extract provides nutrients, promotes skin health, and improves skin elasticity and radiance.

[0007] Cherry blossom extract: Rich in polyphenols and anthocyanins, it effectively neutralizes free radicals, slows down the skin aging process, and reduces the appearance of fine lines and wrinkles. Simultaneously, this extract has a soothing effect, helping to reduce redness, inflammation, and sensitivity, making it suitable for sensitive skin. In terms of moisturizing, it strengthens the skin barrier function, locks in moisture, and keeps skin soft and smooth. Furthermore, cherry blossom extract is often used to brighten skin tone, improve skin texture, and as a natural fragrance ingredient in cosmetics, adding gentleness and appeal to products.

[0008] Saffron flower extract: Rich in carotenoids, flavonoids, and other antioxidants. In skincare and cosmetics, it primarily functions as an antioxidant, helping to neutralize free radicals and slow down the skin aging process. It also possesses anti-inflammatory properties, soothing sensitive skin and reducing redness and irritation. Furthermore, this extract can promote skin brightening, improve uneven skin tone and dullness, resulting in a more even and radiant complexion.

[0009] Bordeaux leaf extract: Rich in flavonoids and essential oils, it effectively neutralizes free radicals, slows down the skin aging process, and reduces the appearance of wrinkles and age spots. In addition, this extract has anti-inflammatory and soothing properties, making it suitable for sensitive or easily irritated skin. It helps reduce redness and discomfort and exhibits mild antibacterial effects, contributing to maintaining clean and healthy skin.

[0010] Glucosyl hesperidin: Glucosyl hesperidin is a natural flavonoid derivative extracted from citrus fruits and commonly used in skincare and cosmetics. Its main functions include anti-oxidation, anti-inflammation, and skin whitening. As an antioxidant, it neutralizes free radicals, slows down the skin aging process, and reduces fine lines and wrinkles. Its anti-inflammatory properties help soothe sensitive skin, reducing redness and irritation. In terms of skin whitening, glucosyl hesperidin inhibits tyrosinase activity, reducing melanin production, thereby brightening the complexion and fading dark spots. Furthermore, it enhances the skin barrier function, provides mild moisturizing effects, improves skin microcirculation, and makes the skin healthier and more radiant.

[0011] The inventors discovered through experiments that when the above components are combined in a specific formulation to form a composition, the composition has synergistic effects of barrier repair, anti-inflammatory soothing, and gentle whitening, making it suitable for use on sensitive skin.

[0012] Preferably, the soothing, repairing, and whitening composition comprises the following components in parts by weight: 3 parts of *Lithocarpus septemlobus* extract, 2.5 parts of *Prunus serrulata* flower extract, 2 parts of saffron flower extract, 1 part of Bordeaux leaf extract, and 0.8 parts of glucosyl hesperidin.

[0013] Preferably, the preparation method of the soothing, repairing, and whitening composition includes the following steps: mixing the extracts of *Lithocarpus septemlobus*, *Prunus serrulata*, *Saffron*, *Bordeaux* leaves, and glucosyl hesperidin in proportion to weight to obtain the soothing, repairing, and whitening composition.

[0014] Secondly, the present invention provides the application of the soothing, repairing, and whitening composition described in the first aspect in the preparation of cosmetics.

[0015] Preferably, the cosmetic is any one of lotion, toner, cream, mask, freeze-dried powder, and spray.

[0016] Preferably, the amount of the soothing, repairing, and whitening composition added is 1%-10% of the total weight of the cosmetic.

[0017] Thirdly, the present invention provides an emulsion comprising the following raw materials by weight percentage: 1%-10% of the composition described in the first aspect, 2.5%-20.5% of a moisturizer, 3%-10% of a skin moisturizer, 1.5%-3% of an emulsifier, 0.1%-1% of an antioxidant, 0.1%-0.5% of a thickener, 0.03%-0.2% of a chelating agent, and 0.1%-0.6% of a pH adjuster, with the balance being deionized water.

[0018] Preferably, the raw material is selected from at least one of (a)-(g): (a) The moisturizer includes at least one of glycerin, propylene glycol, butylene glycol, hexanediol, allantoin, betaine, and sodium hyaluronate; (b) The emollients include at least one of the following: caprylic / capric triglyceride, polydimethicone, cetearyl alcohol, squalane, meadowfoam seed oil, C10-18 fatty acid triglycerides, shea butter, and hydrogenated polyisobutylene; (c) The emulsifier comprises at least one of hydrogenated lecithin, C14-22 alcohol / C12-20 alkyl glucoside, cetearyl alcohol / cetearyl glucoside, polyglycerol-6 distearate, sodium stearoyl glutamate, arachidonic acid / behenol / arachidonic acid glucoside, cetearyl oleate / sorbitan oleate; (d) The antioxidants include p-hydroxyacetophenone; (e) The thickener comprises at least one of carbomer, xanthan gum, sodium polyacrylate, ammonium acryloyl dimethyl taurate / VP copolymer, acrylate copolymer, sclerotium gum, carboxymethyl cellulose, ethyl cellulose, sclerotium tartrate gum, guar gum, gellan gum, and carrageenan; (f) The pH adjuster includes at least one of arginine and tromethamine; (g) The chelating agent includes EDTA-2Na.

[0019] Preferably, the method for preparing the emulsion includes the following steps: S1. Mix some of the humectant, chelating agent, thickener and deionized water, heat to 75-85℃, and homogenize at 6000-9000 rpm for 3-6 minutes. After homogenization, keep warm for later use to obtain the pre-prepared phase A. S2. Mix the emollient and emulsifier, heat to 75-85℃, and homogenize at 6000-9000 rpm for 3-6 minutes. After homogenization, keep warm for later use to obtain the pre-prepared phase B. S3. Mix the remaining humectant and antioxidant, heat to 55-65℃ to melt, and obtain the pre-prepared C phase; S4. Heat the pre-prepared phase A to 80-85℃, add the pre-prepared phase B, homogenize at 6000-9000 rpm for 3-6 minutes, then cool to 50℃, add the pre-prepared phase C at 300-500 rpm and stir until well mixed, then cool to 45℃, add the composition and continue stirring for 5-10 minutes, finally add a pH adjuster to adjust the pH, then stop stirring, discharge the material to obtain the emulsion.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows: The soothing, repairing, and whitening composition for sensitive skin provided by this invention includes extracts of *Lithocarpus stolonifera*, cherry blossom extract, saffron flower extract, Bordeaux leaf extract, and glucosyl hesperidin. These five components work synergistically through multiple pathways, including antioxidant, repairing and moisturizing, anti-inflammatory and stabilizing effects, and promoting microcirculation, simultaneously achieving soothing, repairing, and whitening effects. Furthermore, this composition is non-allergenic, easy to process, and readily suitable for industrial production, and can be widely applied in various formulations such as lotions, toners, masks, and sprays. Detailed Implementation

[0021] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0022] The raw materials used in the following examples and comparative examples are as follows: Hydrafence extract: purchased from Provital, under the brand name Hydrafence TM ; Cherry blossom extract: purchased from Shanghai Boshuo Industrial Co., Ltd., trade name: cherry blossom extract; Saffron flower extract: purchased from Shaanxi Haochen Biotechnology Co., Ltd.; Bordeaux leaf extract: purchased from Ningxia Xiangcao Biotechnology Co., Ltd.; Starry Sky Algae Extract: Purchased from Givaudan, brand name GravitylTM ; Gardenia flower extract: purchased from Xi'an Dingcui Biotechnology Co., Ltd., trade name: Gardenia Flower Extract; Purple coneflower extract: purchased from SymFinity, a company specializing in purple coneflower extract. Ginkgo biloba extract: purchased from Shaanxi Yunhe Biotechnology Co., Ltd., under the trade name Ginkgo biloba extract.

[0023] Unless otherwise specified, all other materials and reagents used in the examples are commercially available.

[0024] Examples 1-5 and Comparative Examples 1-12 The components and their weight proportions of the soothing, repairing, and whitening compositions for sensitive skin in Examples 1-5 and Comparative Examples 1-12 are shown in Table 1. The total weight of each composition is equal. The preparation method of each composition is as follows: mix each component evenly according to the weight proportions.

[0025] Table 1. Components and their weight parts for each composition

[0026] Note: "-" indicates that no addition is needed.

[0027] Application Example 1-5 and Comparative Application Example 1-12 The compositions of Examples 1-5 and Comparative Examples 1-12 were added to the emulsion at a concentration of 5 wt% to obtain the emulsions of Application Examples 1-5 and Comparative Application Examples 1-12. The formulations are shown in Table 2.

[0028] The methods for preparing emulsions in Application Examples 1-5 and Comparative Application Examples 1-12 include the following steps: S1. Mix some of the humectant, chelating agent, thickener and deionized water, heat to 80°C, and homogenize at 6000 rpm for 3 minutes. After homogenization, keep warm for later use to obtain the pre-prepared phase A. S2. Mix the emollient and emulsifier, heat to 80°C, and homogenize at 6000 rpm for 3 minutes. After homogenization, keep warm for later use to obtain the pre-prepared phase B. S3. Mix the remaining humectant and antioxidant, heat to 60°C to melt, and obtain the pre-prepared phase C. S4. Heat the pre-prepared phase A to 80°C, add the pre-prepared phase B, homogenize at 6000 rpm for 3 minutes, then cool to 50°C, add the pre-prepared phase C at 500 rpm and stir until well mixed, then cool to 45°C, add the composition and continue stirring for 5 minutes, finally add a pH adjuster to adjust the pH, then stop stirring, discharge the material, and obtain the emulsion.

[0029] Table 2. Emulsion formulations of Application Examples 1-5 and Comparative Application Examples 1-12

[0030] Comparative application example 13 (blank emulsion) Compared to Application Example 1, no composition was added to the emulsion in Comparative Application Example 13. The missing amount was made up with an equal amount of deionized water, and the preparation method was the same as in Application Example 1.

[0031] Test Example 1: Verification of Barrier Repair Efficacy The scratch assay is an effective way to evaluate the skin barrier repair capacity. By observing cell migration and regeneration after scratching, it can directly reflect the ability of the composition to repair the damaged cellular barrier. In the experiment, by comparing the cell healing speed, the impact of different compositions on skin repair can be assessed.

[0032] The compositions of Examples 1-5 and Comparative Examples 1-12 were used as test samples and the experiments were conducted according to the following steps. The cells used were human keratinocytes (HaCaT, Guangzhou Genio Biotechnology Co., Ltd.). The test conditions were: incubator temperature 37±1℃, humidity 90±5%, and carbon dioxide 5±1%. Cells were cultured and treated according to the groups, and then tested. Specifically, the test was conducted using two-well cell healing slides, and the test method is as follows: (1) Sample solution preparation: The compositions in Examples 1-5 and Comparative Examples 1-12 were dissolved in quantitative DMSO and then diluted with DMEM high glucose culture medium (Gibco) containing 10% v / v fetal bovine serum to a final concentration of 0.05 wt%, which was recorded as the sample solution and refrigerated. (2) Resuscitating HaCaT cells: Take out the 6-well plate, use sterile forceps to fix the 2-well wound healing inserts in the middle of the corresponding wells, and seed the cell suspension into the 6-well plate with the 2-well wound healing inserts at a density of 6 × 10⁶ cells per well. 6 Add 1 mL of DMEM high glucose culture medium (Gibco) containing 10% v / v fetal bovine serum to each well and revive and culture for 24 h; (3) Drug administration: Add 1 mL of DMEM culture medium containing 0.05% of the corresponding sample solution to the sample group, remove the insert, and continue to culture for 48 h; (4) Photographs: The cell scratches of each group were photographed under a microscope at 0h and 48h, and the area of ​​the scratches was measured.

[0033] The skin barrier repair capability of the sample is represented by the cell scratch healing rate, calculated using the following formula: Cell healing rate (%) = (cell scratch area 0h - cell scratch area 48h) / cell scratch area 0h × 100%.

[0034] Three parallel controls were set up for each test sample, and the average value of the results was taken. The specific data are shown in Table 3.

[0035] Test Example 2: Verification of Anti-inflammatory and Soothing Efficacy TNF-α is the most common inflammatory cytokine in inflammatory responses. It can induce an inflammatory phenotype in vascular endothelial cells, leading to changes in metabolism and hemodynamics, and promoting the production of inflammatory mediators. These inflammatory mediators can increase vascular permeability, causing local congestion and edema, and may also stimulate nerve endings, resulting in itching and pain. Therefore, inhibition of TNF-α can help soothe and repair the skin. In this experiment, the TNF-α inhibition rate of different compositions was compared to evaluate the effects of various compositions on skin repair.

[0036] The compositions of Examples 1-5 and Comparative Examples 1-12 were used as test samples and the experiments were conducted according to the following steps. The cells used were logarithmically growing RAW264.7 cells (Wuhan Saisuo Biotechnology Co., Ltd.). The test conditions were: incubator temperature 37±1℃, humidity 90±5%, and carbon dioxide 5±1%. The test method is as follows: S1. Seeding: Logarithmically growing RAW264.7 cells were seeded into 24-well plates at a cell density of 2 × 10⁻⁶ cells / well. 6 Cells / mL, 0.5mL per well, after plating the plate, mark the top cover of the cell plate and incubate in a CO2 incubator for 24 h; S2. Sample preparation: After cell incubation for 24 hours, the supernatant was aspirated, and samples of less than 0.5 mL were added: ① Blank control group: DMEM medium; ② Model group: 1 μg / mL LPS (DMEM medium containing 1 μg / mL LPS); ③ Experimental group: 0.5 wt% composition + 1 μg / mL LPS (DMEM medium containing 0.5 wt% of the compositions of Examples 1-5 and Comparative Examples 1-12 and 1 μg / mL LPS respectively); Each sample group was prepared in 3 replicates. S3. Detection of inflammatory factors in cell supernatants of each group: After 24 hours of cell treatment, the supernatant was pipetted into centrifuge tubes, centrifuged at 1000 rpm for 5 minutes, the precipitate was discarded, and the supernatant was collected. The changes in inflammatory factors in the supernatant were detected using the Xinbosheng TNF-α inflammatory factor detection kit. The results are expressed as TNF-α inhibition rate, calculated using the following formula: TNF-α inhibition rate (%) = (average TNF-α level in the model group - average TNF-α level in the experimental group) / (average TNF-α level in the model group - average TNF-α level in the blank control group) × 100%.

[0037] See Table 3 for specific data.

[0038] Test Example 3: Verification of Gentle Whitening Efficacy The pigmentation-related genes in zebrafish are highly similar to those in humans in terms of sequence and regulatory mechanisms, and their transparent bodies make them suitable for microscopic observation. Therefore, they are often used as a substitute for human melanin inhibition experiments. This test directly verifies the inhibitory effect of the composition on melanin production in vivo by detecting the inhibition rate of the composition on melanin in zebrafish. Both dermal and epidermal pigmentation are caused by melanin accumulation. Therefore, the higher the inhibition rate of the composition on melanin, the better the whitening effect of the composition. The specific test method is as follows: 1. Materials and Reagents Biological material: zebrafish embryos 6-8 hours after fertilization (selection criteria: normal morphology, developed to the blastocyst stage); Reagents: Zebrafish embryo culture medium (containing methylene blue for antifungal purposes), phenylthionamide solution (PTU, concentration 1.5 mg / mL, used to inhibit melanocyte migration), and test samples containing the compositions in Examples 1-5 or Comparative Examples 1-12 (mass concentration 10 wt%, solvent is fish embryo culture medium). Zebrafish embryo culture medium: Prepared by dissolving 2940mg anhydrous calcium chloride, 1233mg magnesium sulfate heptahydrate, 630mg sodium bicarbonate, 55mg potassium chloride, and 1g methylene blue in 10L of water. The pH value is 6.5-8.5. All chemicals are of analytical grade.

[0039] 2. Experimental Grouping Control group: 200 μL embryo culture medium; Control group: 200 μL of embryo culture medium containing 1.5 mg / mL PTU; Sample group: 200 μL of embryo culture medium containing (1.5 mg / mL PTU + 10 wt% whitening composition).

[0040] 3. Operating Procedures (1) Embryo culture: Healthy zebrafish embryos were collected 6-8 h after fertilization, washed, and transferred to 24-well plates. 200 μL of the corresponding treatment solution (blank group, control group, and sample group) was added to each well, with at least 12 embryos in each group. The plates were placed in a constant temperature incubator at 28℃ with a light cycle of 14 h light / 10 h dark, and cultured until 48 hpf (hourly embryonic age).

[0041] (2) Sample preparation and photography: Embryo fixation: Gently peel off the chorionic membrane of the embryo with tweezers to avoid damaging the fish.

[0042] Positioning adjustment: Place the embryo on a glass slide with its back facing up, and cover it with 3% methylcellulose to fix it in place.

[0043] Microscopic imaging: Images were taken using a stereomicroscope with uniform parameters.

[0044] (3) Quantitative analysis of melanin Image import: Open the captured image using ImageJ and convert it to 8-bit grayscale format.

[0045] Region marking: Manually delineate the head and back of the yolk sac (avoiding the extension of the yolk sac).

[0046] Intensity measurement: Calculate the average gray value of pixels within the selected area as the melanin content index (MCI).

[0047] The zebrafish melanin inhibition rate was calculated using the following method. A higher inhibition rate indicates that the composition has a better effect on inhibiting melanin production and improving pigmentation. The calculation method is as follows: Melanin inhibition rate (%) = (Melanin content in the blank group - Melanin content in the sample group) / (Melanin content in the blank group - Melanin content in the control group) × 100% See Table 3 for specific data.

[0048] Table 3 Example 1 69.4 55.2 49.7 Example 2 74.2 58.6 52.3 Example 3 82.6 71.5 68.4 Example 4 79.3 66.8 62.1 Example 5 77.5 63.4 59.8 Comparative Example 1 48.2 32.6 38.5 Comparative Example 2 52.5 28.4 42.0 Comparative Example 3 55.8 30.1 35.6 Comparative Example 4 50.3 35.2 40.3 Comparative Example 5 53.1 38.5 31.2 Comparative Example 6 62.4 48.3 45.6 Comparative Example 7 58.9 42.7 48.2 Comparative Example 8 56.2 41.5 41.3 Comparative Example 9 54.5 44.8 43.7 Comparative Example 10 51.8 40.3 35.4 Comparative Example 11 61.6 49.2 50.1 Comparative Example 12 59.3 45.6 44.5 As shown in Table 3, the composition of the present invention can effectively improve the cell healing rate, the inhibition rate of inflammatory factor TNF-α, and the inhibition rate of melanin, indicating that the composition of the present invention has good barrier repair, anti-inflammatory and soothing, and gentle whitening effects. Among them, Example 3 showed the best performance.

[0049] Based on the data from Example 3 and Comparative Examples 1-5, it can be seen that when any one of the following is missing from the composition: *Lithocarpus serratus* extract, *Prunus serrulata* flower extract, *Saffron crocus* flower extract, *Bordeaux leaf* leaf extract, and glucosyl hesperidin, the soothing, repairing, and whitening effects of the composition are significantly reduced. Based on the data from Example 3 and Comparative Examples 6-10, it can be seen that when components with similar effects are used to replace *Lithocarpus serratus* extract, *Prunus serrulata* flower extract, *Saffron crocus* flower extract, *Bordeaux leaf* leaf extract, and glucosyl hesperidin in equal amounts, the composition is significantly improved. At the same time, the soothing, repairing, and whitening effects of the composition also showed a significant decrease. Combined with the data from Example 1 and Comparative Examples 11-12, it can be seen that the dosage ratio of *Lithocarpus serratus* extract, *Prunus serrulata* flower extract, *Saffron* flower extract, *Bordeaux leaf* extract, and glucosyl hesperidin also affects the efficacy of the composition. When the dosage ratio of *Lithocarpus serratus* extract, *Prunus serrulata* flower extract, *Saffron* flower extract, *Bordeaux leaf* extract, and glucosyl hesperidin does not fall within the scope of protection claimed in this invention, the soothing, repairing, and whitening effects of the composition also decrease. Therefore, it can be seen that the specific dosage ratio of *Lithocarpus serratus* extract, *Prunus serrulata* flower extract, *Saffron* flower extract, *Bordeaux leaf* extract, and glucosyl hesperidin in this invention can exert a synergistic effect in soothing, repairing, and whitening.

[0050] Application Test Example 1: Human Skin Patch Test Thirty volunteers were recruited for the trial, 15 men and 15 women, aged 20-50 years. All participants signed informed consent forms. To simulate the barrier damage commonly seen in sensitive skin, we pre-existed a more stringent testing environment by repeatedly peeling off medical 3M tape five times on the flexor surfaces of the participants' arms. A closed patch test was used. Equal amounts (0.5g-0.6g) of the test sample (the emulsions prepared in Application Examples 1-5 and Control Examples 1-13) were placed in two 10-well patch applicators. These were then applied to the volunteers' arms with hypoallergenic tape, with nine sets of test samples applied to each arm. The samples were gently pressed to ensure even application to the skin and left for 24 hours. After 24 hours, the patch applicators were removed, and skin reactions were observed and recorded at 0.5h, 24h, and 48h. The severity of adverse skin reactions is shown in Table 4 below.

[0051] Table 4 Skin Reaction Grading Standards 0 negative reaction 1 Suspicious reaction, only slight erythema 2 Weak positive reaction (erythema reaction): erythema, infiltration, edema, and papules may be present. 3 Strong positive reaction (herpes reaction): erythema, infiltration, edema, papules; the reaction may extend beyond the test area. 4 Extremely strong positive reaction (confluent herpes simplex reaction): obvious erythema, severe infiltration, edema, confluent herpes simplex; reaction extends beyond the test area. The results showed that the emulsions prepared in Application Examples 1-5 and Comparative Application Examples 1-13 of the present invention all had negative reactions, indicating that the emulsions provided by the present invention are safe and non-irritating to human skin, suitable for people with sensitive skin, and have high safety and gentleness.

[0052] Application Test Example 2: Human Efficacy Trial The effects of the emulsions prepared in Application Examples 1-5 and Comparative Application Examples 1-13 on skin barrier repair, soothing redness reduction, and skin tone improvement of this invention are investigated through the following steps: We are recruiting Asian female volunteers aged 40-60 who meet the following criteria: a) have freckles or dull skin; b) have skin barrier damage (TEWL ≥ 20 g / hm). 2 (c) Self-reported history of skin sensitivity (confirmed by a dermatologist); (d) No history of serious systemic diseases or skin conditions. Exclusion criteria: Pregnant / lactating women, individuals with severe allergies, and individuals who have participated in other clinical trials within the past 3 months.

[0053] On the day of the visit, volunteers were instructed not to apply any products to their face. After washing their faces, they sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10%. They were then randomly divided into 18 groups of 5 people each. The TewaMeter transdermal moisture loss probe was used to measure the transdermal moisture loss. ® The TM Hex (Courage+Khazaka) and Colorimeter CL400 color probe measured the initial TEWL, initial a*, and ITA° values ​​of each volunteer's left and right sides of the face, and the average values ​​were taken. Each group of volunteers applied the same amount of lotion to their face twice a day, morning and evening. Then, on day 28, the post-application TEWL, post-application a*, and post-application ITA° values ​​of the facial skin were measured again, and the average values ​​were taken. The improvement rate (%) was then calculated using the following formula based on the corresponding average values: TEWL value improvement rate (%) = (initial TEWL value - TEWL value after use) / initial TEWL value × 100%; a* value improvement rate (%) = (initial a* value - a* value after use) / initial a* value × 100%; ITA° value improvement rate (%) = (initial ITA° value - ITA° value after use) / initial ITA° value × 100%; Among them, the higher the TEWL value improvement rate, the stronger the skin barrier repair ability of the serum; the higher the a* value improvement rate, the stronger the soothing and redness-reducing ability of the serum; the higher the ITA° value improvement rate, the stronger the whitening and brightening ability of the serum; see Table 5 for specific results.

[0054] Table 5 Application Example 1 31.6 16.3 20.2 Application Example 2 34.2 18.1 23.5 Application Example 3 42.5 26.7 31.8 Application Example 4 38.1 23.4 27.6 Application Example 5 35.7 21.8 25.3 Comparative Application Example 1 18.4 6.2 14.1 Comparative Application Example 2 20.8 5.7 16.4 Comparative Application Example 3 22.9 5.9 13.6 Comparative Application Example 4 19.3 7.1 14.5 Comparative Application Example 5 21.4 8.5 10.9 Comparative Application Example 6 26.3 12.4 18.7 Comparative Application Example 7 24.2 10.8 19.5 Comparative Application Example 8 23.5 10.1 15.6 Comparative Application Example 9 21.5 11.1 17.3 Comparative Application Example 10 20.1 9.9 12.8 Comparative Application Example 11 25.6 13.0 19.7 Comparative Application Example 12 24.7 11.2 18.2 Comparative Application Example 13 8.5 2.2 4.3 As shown in Table 5, compared with the control application example 13 (i.e., blank emulsion), the application examples 1-5 emulsions with added soothing, repairing, and whitening compositions performed better in improving TEWL, a* value, and ITA° value, with application example 3 showing the best performance. Combining the data from application example 1 and control application examples 1-12, it can be seen that when the emulsion contains a composition formulated with extracts of Lithops spurii, Cherry blossom extract, Saffron flower extract, Bordeaux leaf extract, and glucosyl hesperidin in a specific ratio, the emulsion has better barrier repair, soothing and redness reduction, and whitening and brightening effects.

[0055] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A soothing, repairing, and whitening composition for sensitive skin, characterized in that, It includes the following components in parts by weight: 2-5 parts of *Lithocarpus septum* extract, 1-3 parts of *Prunus serrulata* flower extract, 1-3 parts of *Saffron crocus* flower extract, 0.5-1 part of *Bordeaux* leaf extract, and 0.5-2 parts of glucosyl hesperidin.

2. The soothing, repairing, and whitening composition as described in claim 1, characterized in that, The preparation method of the soothing, repairing, and whitening composition includes the following steps: mixing the extracts of *Lithocarpus septemlobus*, *Prunus serrulata*, *Saffron*, *Bordeaux* leaves, and glucosyl hesperidin in proportion to weight to obtain the soothing, repairing, and whitening composition.

3. The use of the soothing, repairing, and whitening composition as described in claim 1 in the preparation of cosmetics.

4. The application of the soothing, repairing, and whitening composition as described in claim 3 in the preparation of cosmetics, characterized in that, The cosmetic product is any one of lotion, toner, cream, mask, freeze-dried powder, and spray.

5. The application of the soothing, repairing, and whitening composition as described in claim 3 in the preparation of cosmetics, characterized in that, The soothing, repairing, and whitening composition is added at a rate of 1%-10% of the total weight of the cosmetic.

6. An emulsion, characterized in that, The ingredients comprise the following ingredients by weight percentage: 1%-10% of the composition described in claim 1, 2.5%-20.5% of a moisturizer, 3%-10% of a skin emollient, 1.5%-3% of an emulsifier, 0.1%-1% of an antioxidant, 0.1%-0.5% of a thickener, 0.03%-0.2% of a chelating agent, and 0.1%-0.6% of a pH adjuster, with the balance being deionized water.

7. The emulsion as described in claim 6, characterized in that, The raw material is selected from at least one of (a)-(g): (a) The moisturizer includes at least one of glycerin, propylene glycol, butylene glycol, hexanediol, allantoin, betaine, and sodium hyaluronate; (b) The emollients include at least one of the following: caprylic / capric triglyceride, polydimethicone, cetearyl alcohol, squalane, meadowfoam seed oil, C10-18 fatty acid triglycerides, shea butter, and hydrogenated polyisobutylene; (c) The emulsifier comprises at least one of hydrogenated lecithin, C14-22 alcohol / C12-20 alkyl glucoside, cetearyl alcohol / cetearyl glucoside, polyglycerol-6 distearate, sodium stearoyl glutamate, arachidonic acid / behenol / arachidonic acid glucoside, cetearyl oleate / sorbitan oleate; (d) The antioxidants include p-hydroxyacetophenone; (e) The thickener comprises at least one of carbomer, xanthan gum, sodium polyacrylate, ammonium acryloyl dimethyl taurate / VP copolymer, acrylate copolymer, sclerotium gum, carboxymethyl cellulose, ethyl cellulose, sclerotium tartrate gum, guar gum, gellan gum, and carrageenan; (f) The pH adjuster includes at least one of arginine and tromethamine; (g) The chelating agent includes EDTA-2Na.

8. The method for preparing the emulsion as described in claim 6 or 7, characterized in that, Includes the following steps: S1. Mix some of the humectant, chelating agent, thickener and deionized water, heat to 75-85℃, and homogenize at 6000-9000 rpm for 3-6 minutes. After homogenization, keep warm for later use to obtain the pre-prepared phase A. S2. Mix the emollient and emulsifier, heat to 75-85℃, and homogenize at 6000-9000 rpm for 3-6 minutes. After homogenization, keep warm for later use to obtain the pre-prepared phase B. S3. Mix the remaining humectant and antioxidant, heat to 55-65℃ to melt, and obtain the pre-prepared C phase; S4. Heat the pre-prepared phase A to 80-85℃, add the pre-prepared phase B, homogenize at 6000-9000 rpm for 3-6 minutes, then cool to 50℃, add the pre-prepared phase C at 300-500 rpm and stir until well mixed, then cool to 45℃, add the composition and continue stirring for 5-10 minutes, finally add a pH adjuster to adjust the pH, then stop stirring, discharge the material to obtain the emulsion.

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