Electrolyte detection unit and automatic analysis device

Abstract

The problem is to improve the ion replacement rate in an electrolyte detection unit. The solution is that the electrolyte detection unit of the embodiment has a probe, a vortex generating member, and an electrode portion. The probe transports the solution attracted from one end to the other end. The vortex generating member is arranged near the other end of the probe. The electrode portion generates a potential related to a predetermined ion contained in the container after the area where the vortex generating member is arranged.

Description

[0001] Cross-reference with related applications: This application is based on and claims priority to Japanese Patent Application No. 2025-018616, filed on February 6, 2025, the entire contents of which are incorporated herein by reference. Technical Field

[0002] The implementation methods described in this article generally involve electrolyte detection units and automated analysis devices. Background Technology

[0003] Electrolyte measuring units, which electrochemically measure the concentration of specific electrolytes in solution, are now widely integrated into automated analytical devices, primarily for measuring sodium, potassium, and chloride ions in samples from biological sources. This electrolyte measuring unit attracts a solution (a mixture of sample and reagents, such as diluents) and measures the potential of the electrodes corresponding to the aforementioned ions, thereby measuring the electrolyte concentration. However, after measuring the electrolyte concentration of a particular sample, a calibration solution needs to be attracted before measuring the electrolyte concentration of other samples for calibration of the electrolyte detection unit within the measuring unit.

[0004] Previously, in the calibration of electrolyte detection units, a sufficient amount of calibration solution was required to displace ions contained in the sample mixture being measured over the ion exchange membrane. That is, in electrolyte detection units, when the ion replacement rate over the ion exchange membrane is low, the required solution volume sometimes increases. In such cases, for example, it may be necessary to repeatedly aspirate the calibration solution until the electrolyte concentration reaches the specified concentration, potentially reducing the throughput of electrolyte concentration measurement checks in automated analyzers. Therefore, there is a need to improve the ion replacement rate in electrolyte detection units.

[0005] Existing technical documents: Japanese Patent Application Publication No. 2010-167107 Summary of the Invention

[0006] The problem to be solved by the present invention is to improve the ion replacement rate in the electrolyte detection unit.

[0007] The electrolyte detection unit of this embodiment includes a probe, an eddy current generating component, and an electrode. The probe transports a solution drawn from one end to the other. The eddy current generating component is disposed near the other end of the probe. The electrode generates a potential related to a predetermined number of ions contained in the container after passing through the area where the eddy current generating component is disposed.

[0008] The invention improves the ion replacement rate in the electrolyte detection unit. Attached Figure Description

[0009] Figure 1 This is a block diagram illustrating an example of the configuration of the automatic analysis device according to the first embodiment.

[0010] Figure 2 It means Figure 1 A diagram illustrating the structure of an analytical organization.

[0011] Figure 3 It means Figure 2 A diagram illustrating an example of the configuration of an electrolyte measurement unit.

[0012] Figure 4 This is a diagram illustrating the configuration of the electrolyte detection unit according to the first embodiment.

[0013] Figure 5 Observing from the -Z direction contains Figure 4 The diagram shows the XY cross-section of the eddy current generating component.

[0014] Figure 6 This is a diagram illustrating the region where Karman eddy currents are generated and the region where the Karman eddy current train continues in the electrolyte detection unit of the first embodiment.

[0015] Figure 7 It is a graph that compares the average slope of each ion electrode in the electrolyte detection unit of the first embodiment between conventional liquid delivery and liquid delivery accompanied by Karman eddy current.

[0016] Figure 8 It is a graph that compares the slope variation of each ion electrode in the electrolyte detection unit of the first embodiment between conventional liquid delivery and liquid delivery accompanied by Karman eddy current.

[0017] Figure 9 This is a diagram illustrating the configuration of the electrolyte detection unit according to the second embodiment.

[0018] Figure 10 It involves inserting the eddy current generating component. Figure 9 The diagram before the end component.

[0019] Figure 11 Viewed from the -Z direction Figure 10 The diagram shows the cross-section along line AA.

[0020] Figure 12 It involves inserting the eddy current generating component. Figure 9 The image shows the end component.

[0021] Figure 13 Viewed from the -Z direction Figure 12 The diagram shows the cross-section of the BB line.

[0022] Explanation of reference numerals in the attached figures: 1…Automatic analysis device, 2…Analytical mechanism, 3…Analytical circuit, 4…Drive mechanism, 5…Input interface, 6…Output interface, 7…Communication interface, 8…Storage circuit, 9…Control circuit, 91…System control function, 100…Sample container, 101…Reagent container, 201…Reaction tray, 2011…Reaction tube, 202…Thermostatic section, 203…Staple sampler, 2031…Sample rack, 204…First reagent storage, 205…Second reagent storage, 206…Sample dispensing arm 207…Sample dispensing probe, 207a…Cleaning tank, 207b…Detergent storage container, 208…First reagent dispensing arm, 209…First reagent dispensing probe, 209a…Cleaning tank, 210…Second reagent dispensing arm, 211…Second reagent dispensing probe, 211a…Cleaning tank, 212…Electrolyte measurement unit, 213…Photometric unit, 214…Cleaning unit, 216…Stirring unit, 300…Reader, 410, 410A…Electrolyte detection unit. 420… Calibration solution storage container, 430… Calibration solution supply pump, 440… Calibration solution tank, 450… Calibration solution waste pump, 460… Waste liquid tank, 470… Suction pump, 510… Electrode section, 511… Body, 511a… Through hole, 512, 513, 514… ISE, 512b, 513b, 514b… Ion exchange membrane, 515… Reference electrode, 520, 620… Suction section, 521, 621… Tube, 521a, 621a… Hollow section, 522, 622…End component, 523, 623…Probe holder, 524…First gasket, 524a…Hollow portion, 525…Second gasket, 525a…Hollow portion, 526, 624…Edge generating component, 622a…First through hole, 622b…Insert hole, 622c…Second through hole, 625…Gasket, 625a…Hollow portion, D1, D2, D3…Directions, FP1, FP2, FP3, FP4, FP5, FP6…Flow path. Detailed Implementation

[0023] Typically, according to one embodiment, the electrolyte detection unit includes a probe, an eddy current generating component, and an electrode. The probe transports a solution drawn from one end to the other. The eddy current generating component is disposed near the other end of the probe. The electrode generates a potential related to predetermined ions contained in the container after passing through the area where the eddy current generating component is disposed.

[0024] Hereinafter, the embodiments of the electrolyte detection unit and the automatic analysis device will be described in detail with reference to the accompanying drawings.

[0025] (First Implementation) Figure 1 This is a block diagram illustrating an example configuration of an automatic analysis device for an implementation method. For example, such as... Figure 1As shown, the automatic analysis device 1 of this embodiment includes an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface 5, an output interface 6, a communication interface 7, a storage circuit 8, and a control circuit 9. Furthermore, the control circuit can also be referred to as a processing circuit.

[0026] The analytical unit 2 mixes a standard sample or a test sample with reagents used in various tests specified for that sample. The analytical unit 2 measures the mixture of sample and reagents, for example, generating standard data and test data correlated with absorbance. Furthermore, the analytical unit 2 measures the mixture of sample and reagents, for example, generating standard data and test data correlated with electrode potential.

[0027] The parsing circuit 3 is a processor that generates calibration data and analytical data by parsing the generated standard data and the tested data. The parsing circuit 3 reads the operation program from the storage circuit 8 and generates calibration data and analytical data according to the read operation program. For example, the parsing circuit 3 generates calibration data based on standard data, which represents the relationship between the standard data and a pre-set standard value for a standard sample. Furthermore, the parsing circuit 3 generates analytical data based on the tested data and the calibration data for the corresponding test item. The analytical data includes data that establishes a correspondence between concentration values ​​and enzyme activity values, as well as data recording the concentrations of desired ions in the sample in a time series. The parsing circuit 3 outputs the generated calibration data and analytical data to the control circuit 9.

[0028] The drive mechanism 4 drives the analysis mechanism 2 under the control of the control circuit 9. The drive mechanism 4 is achieved through gears, a stepper motor, a belt conveyor, and a lead screw. For example, the drive mechanism 4 causes the reaction disk 201 (described later) to rotate at a predetermined angle. The predetermined angle is the angle of rotation in one cycle, for example, approximately 90 degrees. One cycle corresponds to the time interval for sample dispensing and is set to a predetermined number of seconds. For example, an automatic analysis device with one cycle set to 4.5 seconds has the capability to dispense samples every 4.5 seconds.

[0029] Input interface 5, for example, allows the operator to set analytical parameters for various examination items related to the sample to be measured via the hospital's intranet (NW). Input interface 5 can be implemented using a mouse, keyboard, or touchpad for inputting instructions via a touch control surface. Input interface 5 is connected to control circuit 9, converting the operator's input instructions into electrical signals and outputting the electrical signals to control circuit 9.

[0030] Furthermore, in this specification, the input interface 5 is not limited to having physical operating components such as a mouse and keyboard. For example, the input interface 5 may also be a processing circuit that receives electrical signals corresponding to operation instructions input from an external input device and outputs such electrical signals to the control circuit 9, wherein the external input device and the automatic analysis device 1 are separately provided.

[0031] Output interface 6 is connected to control circuit 9 and outputs signals received from control circuit 9. Output interface 6 can be implemented, for example, through display circuitry, printed circuitry, and audio equipment.

[0032] Display circuits include CRT monitors, liquid crystal displays (LCDs), organic EL displays, LED displays, and plasma displays. Furthermore, display circuits can also be processing circuits that convert data representing the displayed object into video signals and output those video signals externally. Printing circuits include printers. Furthermore, printing circuits can also be output circuits that output data representing the printed object externally. Sound devices include speakers. Furthermore, sound devices can also be output circuits that output sound signals externally.

[0033] Communication interface 7 is connected, for example, to the hospital intranet NW. Communication interface 7 communicates with the Hospital Information System (HIS) via the hospital intranet NW. Alternatively, communication interface 7 can also communicate with the HIS via an examination department system connected to the hospital intranet NW.

[0034] The storage circuit 8 includes a recording medium that can be read by a processor, such as a magnetic recording medium, an optical recording medium, or a semiconductor memory. Furthermore, the storage circuit 8 may not necessarily be implemented using a single storage device. For example, the storage circuit 8 may be implemented using multiple storage devices.

[0035] In addition, the storage circuit 8 stores order information such as inspection orders input by the operator or inspection orders received via the hospital intranet NW through the communication interface 7. Order information includes the sample ID, the inspection items to be performed on the sample being measured, and the measurement sequence related to the inspection. The storage circuit 8 stores various set values ​​for executing a series of actions of each part of the automatic analysis device 1 in one cycle, as well as the action program read by the control circuit 9.

[0036] The control circuit 9 is a processor that functions as the central hub of the automatic analysis device 1. For example, the control circuit 9 outputs control signals to the drive mechanism 4 for driving various parts of the analysis mechanism 2. The control circuit 9 implements the function corresponding to the action program stored in the storage circuit 8. In addition, the control circuit 9 may also include a memory that stores at least a portion of the data stored by the storage circuit 8.

[0037] For example, the control circuit 9 has system control function 91 (control unit) by executing an action program. Furthermore, in this embodiment, the system control function 91 is described using a single processor, but it is not limited to this. For example, multiple independent processors can be combined to form the control circuit, and the function can be implemented by each processor executing an action program.

[0038] The control circuit 9, through the system control function 91, such as based on input information input from the input interface 5, uniformly controls the various parts in the automatic analysis device 1. Specifically, the control circuit 9 controls the operation of the electrolyte measurement unit 212, which will be described later.

[0039] The configuration of the automatic analysis apparatus of the first embodiment has been described above. Next, the analysis mechanism of the automatic analysis apparatus of the first embodiment will be described.

[0040] Figure 2 It means Figure 1 A diagram illustrating the structure of an analytical mechanism. For example, such as... Figure 2 As shown, the analysis unit 2 includes a reaction plate 201, a constant temperature section 202, a support sampler 203, a first reagent storage chamber 204, and a second reagent storage chamber 205. Furthermore, the analysis unit 2 includes a sample dispensing arm 206, a sample dispensing probe 207, a cleaning tank 207a, a detergent storage container 207b, a first reagent dispensing arm 208, a first reagent dispensing probe 209, a cleaning tank 209a, a second reagent dispensing arm 210, a second reagent dispensing probe 211, a cleaning tank 211a, an electrolyte measurement unit 212, a photometric unit 213, a cleaning unit 214, and a stirring unit 216.

[0041] The following sections will first describe the reaction plate 201, the constant temperature section 202, the support sampler 203, the first reagent storage 204, and the second reagent storage 205.

[0042] The reaction disk 201 arranges and holds multiple reaction tubes 2011 in a ring. The reaction disk 201 is driven by a drive mechanism 4 to alternately rotate and stop at predetermined time intervals (equivalent to one cycle), for example, 4.5 seconds. The reaction tubes 2011 are made of, for example, glass, polypropylene, or acrylic. Alternatively, the reaction tubes 2011 can also be referred to as reaction vessels or units. Furthermore, the operation of the reaction disk 201 under inspection can also be described as periodic operation.

[0043] The thermostatic unit 202 is a container for storing water (thermostatic water) that is maintained at a specified temperature (typically 37°C). The thermostatic water contains additives, for example, for antibacterial purposes. The thermostatic unit 202 maintains the liquid (e.g., a mixture) contained in the reaction tube 2011 at a constant temperature by immersing the reaction tube 2011 in the stored thermostatic water.

[0044] The support sampler 203 supports the sample holder 2031 for mobility, the sample holder 2031 being capable of holding multiple sample containers 100 that contain the samples to be measured. Figure 2 The example shown illustrates a sample holder 2031 capable of holding five sample containers 100 side by side.

[0045] The sampler 203 includes a reader 300. The reader 300 is positioned, for example, at a location capable of reading a mark attached to the sample container 100. The mark is a code, such as a barcode, one-dimensional pixel code, or two-dimensional pixel code, that encodes identification information of the sample contained in the sample container 100. The reader 300 begins reading the mark upon receiving an indication from the control circuit 9 to begin reading it. When the sample container 100 reaches a position where the mark can be read, the reader 300 reads the sample's identification information from that mark. The reader 300 outputs the read identification information to the control circuit 9. Alternatively, the reader 300 can be replaced by another sensor utilizing RFID (Radio Frequency Identification, etc.). In the case where the reader 300 is replaced by an RFID-based sensor, the mark attached to the sample container 100 is replaced by an IC tag.

[0046] A transport area is provided in the support sampler 203, in which the sample holder 2031 is transported from the input position of the sample holder 2031 to the retrieval position of the sample holder 2031 after measurement is completed. In the transport area, multiple sample holders 2031 arranged along the width direction are moved in the arrangement direction D1 of the multiple sample holders 2031 by the drive mechanism 4.

[0047] Furthermore, in the sampler 203, an introduction area is provided to introduce the sampler 2031 from the transport area in order to move the sample container 100 held by the sample holder 2031 to a predetermined sample aspiration position. The sample aspiration position is, for example, located at the intersection of the rotation track of the sample dispensing probe 207 (described later) and the movement track of the opening of the sample container supported by the sampler 203 and held by the sample holder 2031. In the introduction area, the transported sample holder 2031 is moved in a direction D2, perpendicular to direction D1 in the horizontal plane, by the drive mechanism 4. Furthermore, at a position where the mark in the introduction area can be read, the reader 300 reads the mark attached to the sample container held by the sample holder 2031 moving in direction D2.

[0048] Furthermore, a return area is provided in the sampler 203, which is used to return the sample holder 2031, which holds the sample container that has attracted the sample, to the transport area. In the return area, the sample holder 2031 is moved in a direction D3, opposite to direction D2, by a drive mechanism 4.

[0049] The first reagent storage 204 refrigerates multiple reagent containers 101, which contain first reagents that react with specified components contained in a standard sample or a specified component contained in a test sample. Although in Figure 2 Not shown in the diagram, but the first reagent storage compartment 204 is covered by a removable reagent cover. A reagent rack is rotatably mounted inside the first reagent storage compartment 204. The reagent rack arranges and holds multiple reagent containers 101 in a circular shape. The reagent rack is rotated by a drive mechanism 4.

[0050] A first reagent aspiration position is set at a predetermined location on the first reagent storage 204. The first reagent aspiration position is, for example, set at the intersection of the rotation track of the first reagent dispensing probe 209 (described later) and the moving track of the reagent container 101 arranged in a ring on the reagent rack.

[0051] The second reagent storage 205, for example, refrigerates multiple reagent containers 101, which contain second reagents paired with the first reagent of the two-reagent system. Although in Figure 2 Not shown in the diagram, but the second reagent storage compartment 205 is covered by a removable reagent cover. A reagent rack is rotatably mounted inside the second reagent storage compartment 205. The rack arranges and holds multiple reagent containers 101 in a circular shape. Furthermore, the second reagent refrigerated in the second reagent storage compartment 205 can also be a reagent of the same composition and concentration as the first reagent refrigerated in the first reagent storage compartment 204. That is, the first reagent storage compartment 204 and the second reagent storage compartment 205 can also hold the same type of reagents.

[0052] A second reagent aspiration position is set at a predetermined location on the second reagent storage 205. The second reagent aspiration position is, for example, located at the intersection of the rotation track of the second reagent dispensing probe 211 and the moving track of the reagent container 101 arranged in a ring on the reagent rack.

[0053] Next, the sample dispensing arm 206, sample dispensing probe 207, cleaning tank 207a, detergent storage container 207b, first reagent dispensing arm 208, first reagent dispensing probe 209, cleaning tank 209a, second reagent dispensing arm 210, second reagent dispensing probe 211, cleaning tank 211a, electrolyte measurement unit 212, photometric unit 213, cleaning unit 214, and stirring unit 216 will be described.

[0054] The sample dispensing arm 206 is positioned between the reaction plate 201 and the support sampler 203. The sample dispensing arm 206 is configured to move freely up and down in the vertical direction and rotate freely in the horizontal direction via the drive mechanism 4. The sample dispensing arm 206 holds the sample dispensing probe 207 at one end.

[0055] The sample dispensing probe 207 rotates along an arc-shaped rotation track as the sample dispensing arm 206 rotates. The opening of the sample container, held by the sample holder 2031 on the support sampler 203, is located on this rotation track.

[0056] Furthermore, a sample discharge position is provided on the rotating track of the sample dispensing probe 207 for discharging the sample attracted by the sample dispensing probe 207 into the reaction tube 2011. The sample discharge position corresponds to the intersection of the rotating track of the sample dispensing probe 207 and the moving track of the reaction tube 2011 held in the reaction disk 201.

[0057] Furthermore, a cleaning position for cleaning the sample dispensing probe 207 is provided at a location on the rotation track of the sample dispensing probe 207 that differs from the sample aspiration position and the sample discharge position. A cleaning tank 207a for cleaning the sample dispensing probe 207 is provided at the cleaning position.

[0058] Alternatively, a detergent aspiration position for attracting detergent can be provided on the rotation track of the sample dispensing probe 207 at a location different from the sample aspiration position, sample discharge position, and cleaning position. A detergent storage container 207b can also be provided at the detergent aspiration position, storing detergent for cleaning the electrolyte measurement unit described later.

[0059] The sample dispensing probe 207 is driven by the drive mechanism 4 and moves vertically above the opening of the sample container held by the sample holder 2031 on the support sampler 203, at the sample discharge position, the cleaning position, or the detergent suction position.

[0060] Furthermore, the sample dispensing probe 207, under the control of the control circuit 9, draws the sample from the opening of the sample container. Additionally, under the control of the control circuit 9, the sample dispensing probe 207 dispenses the drawn sample into the reaction tube 2011 located directly below the sample discharge position. The sample dispensing probe 207 performs this series of dispensing actions once, for example, during one cycle.

[0061] Furthermore, under the control of the control circuit 9, the sample dispensing probe 207 draws cleaning fluid from the cleaning tank 207a located directly below the cleaning position on the rotating track of the sample dispensing probe 207. The cleaning fluid may be, for example, pure water, an alkaline detergent for probe cleaning, or an acidic detergent for probe cleaning. Under the control of the control circuit 9, the sample dispensing probe 207 discharges the drawn cleaning fluid into the reaction tube 2011 located directly below the sample discharge position. Thus, the sample dispensing probe 207 and the reaction tube 2011 located directly below the sample discharge position are cleaned. The sample dispensing probe 207 performs this series of cleaning actions once, for example, during one cycle.

[0062] Furthermore, when the automatic analysis device 1 includes a detergent storage container 207b, the sample dispensing probe 207, under the control of the control circuit 9, draws detergent from the detergent storage container 207b, which is located directly below the detergent aspiration position on the rotating track of the sample dispensing probe 207. Additionally, under the control of the control circuit 9, the sample dispensing probe 207 discharges the drawn detergent into the reaction tube 2011, located directly below the sample discharge position. The sample dispensing probe 207 performs this series of dispensing operations once, for example, during one cycle.

[0063] The first reagent dispensing arm 208 is positioned between the reaction plate 201 and the first reagent reservoir 204. The first reagent dispensing arm 208 can move freely up and down in the vertical direction and rotate freely in the horizontal direction via a drive mechanism 4. The first reagent dispensing arm 208 holds the first reagent dispensing probe 209 at one end.

[0064] The first reagent dispensing probe 209 rotates along an arc-shaped rotation track as the first reagent dispensing arm 208 rotates. A first reagent aspiration position is provided on this rotation track. Furthermore, a first reagent discharge position is provided on the rotation track of the first reagent dispensing probe 209 to discharge the reagent aspirated by the first reagent dispensing probe 209 into the reaction tube 2011. The first reagent discharge position corresponds to the intersection of the rotation track of the first reagent dispensing probe 209 and the moving track of the reaction tube 2011 held on the reaction disk 201. Additionally, a cleaning position for cleaning the first reagent dispensing probe 209 is provided at a location on the rotation track of the first reagent dispensing probe 209 that differs from both the first reagent aspiration position and the first reagent discharge position. A cleaning tank 209a for cleaning the first reagent dispensing probe 209 is provided at the cleaning position.

[0065] The first reagent dispensing probe 209 is driven by the driving mechanism 4 and moves up and down along the first reagent aspiration position, the first reagent discharge position, or the cleaning position on the rotating track.

[0066] The first reagent dispensing probe 209, under the control of the control circuit 9, draws the first reagent from the reagent container located directly below the first reagent aspiration position. That is, the first reagent dispensing probe 209 is an example of the reagent dispensing probe of this embodiment. Furthermore, under the control of the control circuit 9, the first reagent dispensing probe 209 discharges the drawn first reagent into the reaction tube 2011 located directly below the first reagent discharge position. The first reagent dispensing probe 209 performs this series of dispensing operations once, for example, during one cycle.

[0067] The first reagent dispensing probe 209, under the control of the control circuit 9, draws cleaning fluid from the cleaning tank 209a located directly below the cleaning position on the rotating track of the first reagent dispensing probe 209. The first reagent dispensing probe 209, also under the control of the control circuit 9, discharges the drawn cleaning fluid into the reaction tube 2011 located directly below the first reagent discharge position. This cleans both the first reagent dispensing probe 209 and the reaction tube 2011 located directly below the first reagent discharge position. The first reagent dispensing probe 209 performs this series of cleaning actions, for example, once per cycle.

[0068] The second reagent dispensing arm 210 is disposed between the reaction plate 201 and the second reagent reservoir 205. The second reagent dispensing arm 210 is configured to move freely up and down in the vertical direction and rotate freely in the horizontal direction via the drive mechanism 4. The second reagent dispensing arm 210 holds the second reagent dispensing probe 211 at one end.

[0069] The second reagent dispensing probe 211 rotates along an arc-shaped rotation track as the second reagent dispensing arm 210 rotates. A second reagent aspiration position is provided on this rotation track.

[0070] Furthermore, a second reagent discharge position is provided on the rotation track of the second reagent dispensing probe 211 for discharging the reagent attracted by the second reagent dispensing probe 211 into the reaction tube 2011. The second reagent discharge position corresponds to the intersection of the rotation track of the second reagent dispensing probe 211 and the moving track of the reaction tube 2011 held in the reaction disk 201.

[0071] Furthermore, a detergent discharge position is set on the rotating track of the second reagent dispensing probe 211 to discharge the detergent attracted by the second reagent dispensing probe 211 into the reaction tube. The detergent discharge position corresponds to the intersection of the rotating track of the second reagent dispensing probe 211 and the moving track of the reaction tube 2011 held in the reaction disk 201, and is a position different from the second reagent discharge position.

[0072] Furthermore, a cleaning position for cleaning the second reagent dispensing probe 211 is provided at a location on the rotation track of the second reagent dispensing probe 211 that differs from the second reagent aspiration position, the second reagent discharge position, and the detergent discharge position. A cleaning tank 211a for cleaning the second reagent dispensing probe 211 is provided at the cleaning position.

[0073] The second reagent dispensing probe 211 is driven by the drive mechanism 4 and moves up and down along the rotation track at the second reagent aspiration position, the second reagent discharge position, the detergent discharge position, or the cleaning position.

[0074] The second reagent dispensing probe 211, under the control of the control circuit 9, draws the second reagent from the reagent container located directly below the second reagent aspiration position. That is, the second reagent dispensing probe 211 is an example of the reagent dispensing probe of this embodiment. Furthermore, under the control of the control circuit 9, the second reagent dispensing probe 211 discharges the drawn second reagent into the reaction tube 2011 located directly below the second reagent discharge position. The second reagent dispensing probe 211 performs this series of dispensing operations once, for example, during one cycle.

[0075] Under the control of the control circuit 9, the second reagent dispensing probe 211 draws cleaning fluid from the cleaning tank 211a located directly below the cleaning position on the rotation track of the second reagent dispensing probe 211. Under the control of the control circuit 9, the second reagent dispensing probe 211 discharges the drawn cleaning fluid into the reaction tube 2011 located directly below the second reagent discharge position. Thus, the second reagent dispensing probe 211 and the reaction tube 2011 located directly below the second reagent discharge position are cleaned. The second reagent dispensing probe 211 performs this series of cleaning actions once, for example, during one cycle.

[0076] The electrolyte measurement unit 212 measures the electrolyte concentration of the sample and reagent mixture discharged into the reaction tube 2011. The electrolyte measurement unit 212 has an ion-selective electrode (ISE) and a reference electrode. Under the control of the control circuit 9, the electrolyte measurement unit 212 measures the potential between the ISE and the reference electrode for the mixture to be measured, thereby detecting the electrolyte concentration of the ions being tested (e.g., sodium ions, potassium ions, and chloride ions). The electrolyte measurement unit 212 outputs the measured potential data as standard data or test data to the analysis circuit 3. The specific configuration of the electrolyte measurement unit 212 will be described later.

[0077] The photometric unit 213 performs optical measurements on specified components in the sample and reagent mixture discharged into the reaction tube 2011. The photometric unit 213 includes a light source and a photodetector. Under the control of the control circuit 9, the photometric unit 213 illuminates light from the light source. The illuminated light enters from the first sidewall of the reaction tube 2011 and exits from the second sidewall opposite to the first sidewall. The photometric unit 213 uses the photodetector to detect the light emitted from the reaction tube 2011.

[0078] Specifically, for example, a photodetector detects light passing through the mixture of standard sample and reagent within the reaction tube 2011, and generates standard data, expressed as absorbance, based on the intensity of the detected light. Similarly, a photodetector detects light passing through the mixture of test sample and reagent within the reaction tube 2011, and generates test data, expressed as absorbance, based on the intensity of the detected light. The photometry unit 213 outputs the generated standard data and test data to the analysis circuit 3.

[0079] The cleaning unit 214 cleans the interior of the reaction tube 2011 after the measurement of the mixture in the electrolyte measurement unit 212 or the photometry unit 213 is completed. The cleaning unit 214 includes a cleaning fluid supply pump (not shown) that supplies cleaning fluid for cleaning the reaction tube 2011. Furthermore, the cleaning unit 214 includes cleaning nozzles (not shown) that discharge the cleaning fluid supplied from the cleaning fluid supply pump into the reaction tube 2011 and draw in the mixture and individual liquids of the cleaning fluid within the reaction tube 2011.

[0080] The stirring unit 216 is disposed near the outer periphery of the reaction plate 201. The stirring unit 216 has a stirring element, which stirs the mixture of the sample and the first reagent contained in the reaction tube 2011 located at the stirring position on the reaction plate 201, or the mixture of the sample, the first reagent, and the second reagent contained in the reaction tube 2011.

[0081] The analysis mechanism of the automatic analysis apparatus according to the first embodiment has been described above. Next, the specific configuration of the electrolyte measurement unit included in the analysis mechanism will be described.

[0082] Figure 3 It means Figure 2 A diagram illustrating an example of the configuration of an electrolyte measurement unit. For example, as shown... Figure 3 As shown, the electrolyte measurement unit 212 includes an electrolyte detection unit 410, a calibration solution storage container 420, a calibration solution supply pump 430, a calibration solution tank 440, a calibration solution waste pump 450, a waste liquid tank 460, and a suction pump 470.

[0083] Furthermore, a flow path FP1, for example, connected by a pipe, is provided between the calibration fluid supply pump 430 and the calibration fluid storage container 420. Similarly, a flow path FP2 is provided between the calibration fluid supply pump 430 and the calibration fluid tank 440. A flow path FP3 is provided between the calibration fluid waste pump 450 and the calibration fluid storage container 420. A flow path FP4 is provided between the calibration fluid waste pump 450 and the waste liquid tank 460. A flow path FP5 is provided between the suction pump 470 and the electrolyte detection unit 410. A flow path FP6 is provided between the suction pump 470 and the waste liquid tank 460.

[0084] The electrolyte detection unit 410 is driven by the drive mechanism 4 and moves between the calibration liquid aspiration position P1 and the mixed liquid aspiration position P2. The calibration liquid aspiration position P1 is set on the calibration liquid storage container 420. The mixed liquid aspiration position P2 is set on the reaction tube 2011 in the reaction tray 201. Furthermore, the electrolyte detection unit 410 has a probe that uses a suction pump 470 to aspirate the calibration liquid at the calibration liquid aspiration position P1 and the mixed liquid at the mixed liquid aspiration position P2.

[0085] Furthermore, the electrolyte detection unit 410 includes the aforementioned ISE and reference electrode, and measures the potential of the calibration solution or mixture. The electrolyte detection unit 410 outputs measurement data related to the calibration solution or mixture to the analysis circuit 3. The specific configuration of the electrolyte detection unit 410 will be described later.

[0086] The calibration fluid storage container 420 stores a predetermined amount of calibration fluid. The stored calibration fluid is supplied by the calibration fluid supply pump 430. In addition, when the calibration fluid is replaced, it is drawn by the calibration fluid waste pump 450.

[0087] The calibration fluid supply pump 430 comprises, for example, a plunger, a syringe, and a three-way valve. The three-way valve is connected to the syringe, flow path FP1, and flow path FP2. When drawing calibration fluid from the calibration fluid tank 440, the calibration fluid supply pump 430 closes the connection of flow path FP1 in the three-way valve and actuates the plunger. When supplying the drawn calibration fluid to the calibration fluid storage container 420, the calibration fluid supply pump 430 closes the connection of flow path FP2 in the three-way valve and actuates the plunger.

[0088] The calibration fluid is contained in the calibration fluid tank 440. The contained calibration fluid is supplied to the calibration fluid storage container 420 via the calibration fluid supply pump 430.

[0089] The calibration fluid waste pump 450 comprises, for example, a plunger, a syringe, and a three-way valve. The three-way valve is connected to the syringe, flow path FP3, and flow path FP4. When drawing calibration fluid from the calibration fluid storage container 420, the connection of flow path FP4 in the three-way valve is closed, and the plunger is actuated. When discarding the drawn calibration fluid into the waste tank 460, the calibration fluid waste pump 450 closes the connection of flow path FP3 in the three-way valve, and the plunger is actuated.

[0090] Waste liquid tank 460 stores waste liquid. The stored waste liquid may be, for example, calibration liquid stored in calibration liquid storage container 420, mixture attracted by electrolyte detection unit 410, and calibration liquid attracted by electrolyte detection unit 410.

[0091] The suction pump 470 comprises, for example, a plunger, a syringe, and a three-way valve. The three-way valve is connected to the syringe, flow path FP5, and flow path FP6. When suctioning the mixture in the reaction tube 2011 or the calibration solution in the calibration solution storage container 420, the connection of flow path FP6 in the three-way valve is closed, and the plunger is actuated. When discarding the suctioned mixture or calibration solution, the connection of FP5 in the three-way valve is closed, and the plunger is actuated.

[0092] There are two types of standard samples with different concentrations of each electrolyte: a first standard sample and a second standard sample. A first standard value representing the concentration of each electrolyte in the first standard sample and a second standard value representing the concentration of each electrolyte in the second standard sample are stored in the storage circuit 8 via input from the input interface 5. Furthermore, the first and second standard values ​​are included in the aforementioned standard data.

[0093] During calibration, sample dispensing probe 207 dispenses the first standard sample into reaction tube 2011, and first reagent dispensing probe 209 dispenses the first reagent into reaction tube 2011 containing the first standard sample. Through the dispensing of the first standard sample and the first reagent, the first standard sample is diluted by the first reagent in reaction tube 2011, becoming a first standard mixture containing a lower concentration of each electrolyte than the calibration solution.

[0094] Similarly, regarding the second standard sample, during calibration, sample dispensing probe 207 dispenses the second standard sample into reaction tube 2011, and first reagent dispensing probe 209 dispenses the first reagent into reaction tube 2011 containing the dispensed second standard sample. Through the dispensing of the second standard sample and the first reagent, the second standard sample is diluted by the first reagent within reaction tube 2011, becoming a second standard mixture containing a higher concentration of each electrolyte than the calibration solution.

[0095] During the test, sample dispensing probe 207 dispenses the test sample, whose electrolyte concentrations are unknown, into reaction tube 2011, and first reagent dispensing probe 209 dispenses the first reagent into reaction tube 2011, which has been dispensed with the test sample. Through the dispensing of the test sample and the first reagent, the test sample in reaction tube 2011 becomes a test mixture diluted with the first reagent.

[0096] The above describes the specific composition of the electrolyte measurement unit possessed by the analytical apparatus. Next, the specific composition of the electrolyte detection unit within the electrolyte measurement unit will be described.

[0097] Figure 4 This is a diagram illustrating the configuration of the electrolyte detection unit according to the first embodiment. For example, as shown... Figure 4 As shown, the electrolyte detection unit 410 includes an electrode section 510 and an attraction section 520.

[0098] The electrode section 510 includes a main body 511, ISE 512, ISE 513, ISE 514 and a reference electrode 515. The electrode section 510 is maintained at a certain temperature (e.g., 37°C).

[0099] The main body 511 is, for example, made of polyvinyl chloride. An attraction direction is formed in the main body 511 (in... Figure 4 A through hole 511a (with the Z-direction as the center) extends through the electrode section 510. Furthermore, multiple openings are formed on the main body 511 in a direction perpendicular to the through hole 511a. ISE 512, ISE 513, ISE 514, and a reference electrode 515 are connected to these openings. Additionally, a cylindrical recess for mounting the suction section 520 is formed in the main body 511. Since the through hole 511a is the portion in which the solution flows into the electrode section 510, it can also be referred to as the "electrode section flow path" (or simply "flow path").

[0100] The ISE512 has an ion-exchange membrane for selectively detecting sodium ions at a position facing the flow path of the electrode section. The ISE512 is connected to an opening formed in the body 511 via this ion-exchange membrane. Under the condition that the activity count of the solution (calibration solution or mixture) flowing into the through hole 511a and the solution temperature are constant, the ISE512 causes the reference electrode 515 to generate a potential proportional to the logarithm of the sodium ion concentration.

[0101] The ISE513 has an ion-exchange membrane for selectively detecting potassium ions at a position facing the flow path of the electrode section. The ISE513 is connected to an opening formed in the body 511 via this ion-exchange membrane. Under the condition that the activity count of the solution (calibration solution or mixture) flowing into the through hole 511a and the solution temperature are constant, the ISE513 causes the reference electrode 515 to generate a potential proportional to the logarithm of the potassium ion concentration.

[0102] The ISE514 has an ion-exchange membrane for selectively detecting chloride ions at a position facing the flow path of the electrode section. The ISE514 is connected to an opening formed in the body 511 via this ion-exchange membrane. Under the condition that the activity count of the solution (calibration solution or mixture) flowing into the through hole 511a and the solution temperature are constant, the ISE514 causes the reference electrode 515 to generate a potential that is inversely proportional to the logarithm of the chloride ion concentration.

[0103] Furthermore, since ion exchange membranes selectively allow specific ions to pass through, they can also be referred to as detection surfaces capable of detecting specific ions. Additionally, the percentage change in the concentration of a specific ion within the ISE when a certain amount of solution (e.g., the amount of solution attracted by the electrolyte detection unit 410 at one time) passes through the surface of the ion exchange membrane can also be called the displacement rate.

[0104] The reference electrode 515 has a liquid junction that generates a certain potential. The reference electrode 515 is connected to an opening formed in the body 511.

[0105] The suction part 520 includes a tube 521, an end part 522, a probe holder 523, a first pad 524, a second pad 525, and an eddy current generating part 526. The suction part 520 is mounted in a cylindrical recess of the main body 511.

[0106] The tube 521 is made of, for example, stainless steel. The inner diameter of the tube 521 (i.e., the outer diameter of the hollow portion 521a of the tube 521) is smaller than the diameter of the through hole 511a. The tube 521 can also be referred to as a "probe". One end of the tube 521 corresponds to the tip of a probe for attracting solution. A terminal component 522 is installed at the other end of the tube 521. Alternatively, the probe can also be a combination of the tube 521 and the terminal component 522.

[0107] The end member 522 is made of, for example, stainless steel. The outer diameter of the end member 522 is the size of the recess that allows it to be installed in the body 511. A through hole with a diameter approximately the same as the outer diameter of the tube 521 is formed in the end member 522. The tube 521 is inserted into the through hole of the end member 522. The tube 521 and the end member 522 are joined, for example, by welding.

[0108] The probe holder 523 is made of, for example, POM (Polyoxymethylene) resin. A through-hole for inserting the probe is formed in the probe holder 523. The probe holder 523 holds the probe by inserting it into the through-hole. Alternatively, a screw mechanism for securing the probe may be provided in the probe holder 523.

[0109] The first gasket 524 is made of, for example, fluororubber. The first gasket 524 is a hollow disk. The outer diameter of the first gasket 524 is approximately the same as the outer diameter of the end member 522. The inner diameter of the first gasket 524 (i.e., the outer diameter of the hollow portion 524a) is approximately the same as or slightly larger than the diameter of the through hole 511a. Furthermore, the second gasket 525 has the same configuration as the first gasket 524, therefore its description is omitted.

[0110] Furthermore, a first gasket 524 and a second gasket 525 are disposed between the probe and the body 511. By disposing the first gasket 524 and the second gasket 525 between the probe and the body 511, leakage caused by the connection between the probe and the body 511 can be prevented.

[0111] The eddy current generating component 526 is made of, for example, a hard material with high corrosion resistance (e.g., stainless steel). The eddy current generating component 526 is cylindrical, particularly cylindrical. The outer diameter of the eddy current generating component 526 is, for example, 1 / 4 to 1 / 3 of the inner diameter of the through hole 511a (electrode flow path) of the electrode portion 510. The overall length of the eddy current generating component 526 is smaller than the outer diameter of the first pad 524 and larger than the inner diameter of the first pad 524 (or the inner diameter of the electrode flow path).

[0112] For example, the vortex generating component 526 is a columnar component arranged intersecting the flow direction of the solution. Specifically, the vortex generating component 526 is arranged such that the hollow portions (i.e., hollow portions 524a and 525a) of the first pad 524 and the second pad 525 are sandwiched between them in a manner that divides the hollow portions at the center. In this case, the vortex generating component 526 can also be fixed to either the first pad 524 or the second pad 525. In addition, the first pad 524 and the second pad 525 sandwiching the vortex generating component 526 are tightly attached to prevent leakage.

[0113] Figure 5 Observing from the -Z direction contains Figure 4 The diagram shows the XY cross-section of the eddy current generating component. (See diagram below.) Figure 5 As shown, the overall length of the vortex generating component 526 is less than the outer diameter of the second pad 525 and greater than the inner diameter of the second pad 525 (i.e., the outer diameter of the hollow portion 525a). Furthermore, the vortex generating component 526 is arranged such that it centrally divides the hollow portion 525a of the second pad 525. That is, the vortex generating component 526 is separated from the first pad 524 (in...) Figure 5 (Not shown in the figure) and the second liner 525 are clamped together, so that the vortex generating component 526 is arranged crosswise with respect to the flow direction of the solution.

[0114] In summary, by connecting the electrode section 510 and the suction section 520, the solution attracted by the probe flows into the through hole 511a of the electrode section 510 through the hollow portion 521a of the tube 521, the hollow portion 524a of the first liner 524, and the hollow portion 525a of the second liner 525. Furthermore, in the suction section 520, by arranging a vortex generating member 526 in the flow path of the solution supply, a vortex (Karman vortex) can be generated behind the vortex generating member 526. Thus, the solution generating the Karman vortex can flow into the through hole 511a of the electrode section 510.

[0115] Figure 6 This diagram illustrates the region where Karman eddy currents are generated and the region where the Karman eddy current train continues in the electrolyte detection unit of the first embodiment. Figure 6 In the diagram, the flow path in the electrolyte detection unit 410 is divided into a probe region, an eddy current generation region, and an eddy current sustaining region, which are shown in a simplified manner. Furthermore, the probe region corresponds to the hollow portion 521a of the tube 521 constituting the probe, the eddy current generation region corresponds to the hollow portion 524a of the first pad 524 and the hollow portion 525a of the second pad 525, which are provided with the eddy current generation component 526, and the eddy current sustaining region corresponds to the through hole 511a of the electrode portion 510.

[0116] The solution attracted by the probe flows in a state of low turbulence within the probe region. When the solution flows from the probe region into the vortex generation region, the flow of the solution is disturbed by the vortex generating component 526, generating Karman vortices. In the vortex persistence region, the Karman vortex can be sustained within a certain range of the solution flow.

[0117] Furthermore, ion exchange membranes 512b of ISE512, 513b of ISE513, and 514b of ISE514 are disposed in the eddy current sustained region. During measurement, these ion exchange membranes displace specific ions between the calibration solution within the ISE and the sample-containing mixture in the flow path; during calibration, they displace specific ions between the solution containing specific ions within the ISE and the calibration solution in the flow path.

[0118] A Karman vortex is a series of vortices generated alternately and continuously by vortices of different rotational directions (e.g., right-handed and left-handed vortices). Furthermore, the group of vortices with different rotational directions has a period (length) corresponding to the diameter of the cylinder of the vortex-generating component. For example, the larger the diameter of the cylinder, the longer the period of the Karman vortex. For example, by providing an ion exchange membrane in a range from the point where the Karman vortex is generated (i.e., the vortex-generating component 526) to six times the period of the Karman vortex, the ion replacement rate can be improved.

[0119] Conventionally, turbulence is generated in the solution by forging the other end of a probe to which the end component is fixed, and the turbulent solution flows into a flow path equipped with an ion exchange membrane. On the other hand, in the first embodiment, a Karman vortex is generated by a vortex generating component 526, thereby causing the solution generating the Karman vortex to flow into a flow path equipped with an ion exchange membrane.

[0120] The following uses Figure 7 and Figure 8 This paper describes the average slope and slope variation of the displacement rate for previous liquid delivery methods and liquid delivery accompanied by Karman eddy currents. The slope is the ratio of the measured voltage difference between different concentrations to the ideal value. That is, it can be said that the closer the slope is to 100%, the higher the displacement rate.

[0121] Figure 7 This is a graph comparing the average slope of each ion electrode in the electrolyte detection unit of the first embodiment between conventional liquid delivery and liquid delivery accompanied by Karman eddy current. The average slope is the average of the slopes measured consecutively five times. Figure 7 The figure shows the measurement results obtained by measuring the average slope of Na, the average slope of K, and the average slope of Cl using three electrode sensors (electrode sections) with different manufacturing numbers.

[0122] The graphs for the average slopes of Na and K both show a near 100% increase in slope during liquid delivery with the Karman vortex compared to conventional delivery. On the other hand, the graph for the average slope of Cl shows a slight decrease in slope during delivery with the Karman vortex compared to conventional delivery. However, the increase in the average slopes of Na and K significantly exceeds the decrease in the average slope of Cl. Therefore, overall, it can be said that the displacement rate is higher during delivery with the Karman vortex compared to conventional delivery.

[0123] Depend on Figure 7 It is known that the more solution flows toward the surface of the ion exchange membrane, the higher the displacement rate. Therefore, it can be concluded that the displacement rate of the flow generating Karman vortices is higher than that of the previous flow that generates irregular turbulence.

[0124] Figure 8This is a graph comparing the slope variations of each ion electrode in the electrolyte detection unit of the first embodiment between conventional liquid delivery and liquid delivery accompanied by Karman eddy current. The slope variation is the average of the slope variations measured consecutively over five consecutive measurements. Figure 8 The text shows the use of... Figure 7 Measurement results of three electrode sensors (electrode sections) with the same manufacturing number but different serial numbers, measuring the slope changes of Na, K, and Cl respectively.

[0125] The graphs of Na slope variation and K slope variation both show that the slope variation with the accompanying Karman vortex is reduced to near zero compared to conventional liquid delivery. On the other hand, the graph of Cl slope variation shows roughly the same slope variation between conventional liquid delivery and liquid delivery with the accompanying Karman vortex. Therefore, overall, it can be said that the measurement stability of liquid delivery with the accompanying Karman vortex is higher than that of conventional liquid delivery.

[0126] In summary, the electrolyte detection unit 410 includes: a probe (tube 521, etc.) for conveying a solution drawn from one end to the other end; a eddy current generating component 526 disposed near the other end of the probe; and an electrode portion 510 for generating a potential related to a specified ion (sodium ion, potassium ion, and chloride ion) contained in the solution after passing through the region (hollow portion 524a and hollow portion 525a) where the eddy current generating component 526 is disposed.

[0127] As described above, the electrolyte detection unit of the first embodiment includes: a probe for conveying a solution drawn from one end to the other end; an eddy current generating member disposed near the other end of the probe; and an electrode portion for generating a potential related to predetermined ions contained in the solution after passing through the region where the eddy current generating member is disposed. Furthermore, in the first embodiment, the eddy current generating member is disposed between two pads provided between the probe and the electrode portion.

[0128] Therefore, the electrolyte detection unit of the first embodiment uses a eddy current generating component to generate Karman eddy currents in the flow of the solution, thereby increasing the flow of the solution toward the surface of the ion exchange membrane, and thus improving the ion replacement rate.

[0129] For example, conventionally, the calibration solution is attracted twice (i.e., two cycles) during the calibration of the electrolyte detection unit. On the other hand, the electrolyte detection unit of the first embodiment can predictably achieve a displacement rate approximately twice that of the conventional unit by increasing the ion displacement rate. Therefore, in the configuration of the electrolyte detection unit of the first embodiment, the attraction of the calibration solution can be completed in one cycle.

[0130] (Second Implementation) The electrolyte detection unit of the first embodiment is configured such that the eddy current generating component is held between two pads. On the other hand, the electrolyte detection unit of the second embodiment is configured such that the eddy current generating component is disposed at the end component.

[0131] Figure 9 This is a diagram illustrating the configuration of the electrolyte detection unit according to the second embodiment. For example, such as... Figure 9 As shown, the electrolyte detection unit 410A includes an electrode section 510 and an attraction section 620.

[0132] The suction part 620 includes a tube 621, an end part 622, a probe holder 623, an eddy current generating part 624, and a gasket 625. The suction part 620 is mounted in a cylindrical recess of the main body 511.

[0133] The tube 621 is made of, for example, stainless steel. The inner diameter of the tube 621 (i.e., the outer diameter of the hollow portion 621a of the tube 621) is smaller than the diameter of the through hole 511a. The tube 621 can also be referred to as a "probe". One end of the tube 621 corresponds to the tip of a probe for attracting solution. A terminal component 622 is installed at the other end of the tube 621. Alternatively, the probe can also be a combination of the tube 621 and the terminal component 622.

[0134] The end member 622 is made of, for example, hard rubber. The outer diameter of the end member 622 is the size of the recess that allows it to be installed in the body 511. A first through hole with a diameter approximately the same as the inner diameter of the tube 621 and a second through hole with a diameter approximately the same as the outer diameter of the tube 621 are formed in the end member 622. Furthermore, the first and second through holes are connected around the same axis. For example, by inserting (pressing) the tube 621 into the second through hole, the first through hole and the hollow portion 621a of the tube 621 become flow paths (end member flow paths) with the same diameter. Additionally, an insertion hole is formed in the end member 622 perpendicularly through the second through hole, into which a vortex generating member 624 is inserted. The length of the insertion hole is shorter than the outer diameter of the end member 622.

[0135] The probe holder 623 is made of, for example, POM resin. A through hole for inserting the probe is formed in the probe holder 623. The probe holder 623 holds the probe by inserting it into the through hole. Alternatively, a screw mechanism for securing the probe may be provided in the probe holder 623.

[0136] The eddy current generating component 624 is made of, for example, a hard material with high corrosion resistance (e.g., stainless steel). The eddy current generating component 624 is cylindrical, particularly cylindrical. The outer diameter of the eddy current generating component 624 is, for example, in the range of 1 / 4 to 1 / 3 of the inner diameter of the first through-hole in which the eddy current generating component 624 is disposed. The overall length of the eddy current generating component 624 is larger than the inner diameter of the first through-hole, but shorter than or the same as the length of the insertion hole.

[0137] For example, the vortex generating component 624 is a columnar component arranged intersecting the flow direction of the solution. Specifically, the vortex generating component 624 is arranged to be inserted (pressed) into the end component perpendicularly to the flow path of the end component 622.

[0138] The gasket 625 is made of, for example, fluororubber. The gasket 625 is a hollow disc. The outer diameter of the gasket 625 is approximately the same as the outer diameter of the end member 622. The inner diameter of the gasket 625 (i.e., the outer diameter of the hollow portion 625a) is approximately the same as or slightly larger than the diameter of the through hole 511a.

[0139] Furthermore, a gasket 625 is disposed between the probe and the body 511. By disposing the gasket 625 between the probe and the body 511, leakage caused by the connection between the probe and the body 511 can be prevented.

[0140] Figure 10 It involves inserting the eddy current generating component. Figure 9 The diagram before the end component. In Figure 10 The diagram shows an end component 622 and an eddy current generating component 624. The end component 622 has a first through hole 622a, an insertion hole 622b, and a second through hole 622c. The insertion hole 622b is perpendicular to the first through hole 622a.

[0141] Figure 11 Viewed from the -Z direction Figure 10 The diagram shows the cross-section along line AA. Figure 10 The AA line includes the central axis of the insertion hole 622b, which is perpendicular to the central axis of the first through hole 622a. Figure 11 A cross-section of the end member 622 is shown. A first through hole 622a and an insertion hole 622b are formed in the end member 622.

[0142] Figure 12 It involves inserting the eddy current generating component. Figure 9 The image shows the end component after the part. Figure 12 The diagram shows an end member 622 and an eddy current generating member 624 inserted into the end member 622. The eddy current generating member 624 is inserted into an insertion hole 622b and passes perpendicularly through the first through hole 622a relative to the central axis of the first through hole 622a.

[0143] Figure 13 Viewed from the -Z direction Figure 12 The diagram shows the cross-section of the BB line. Figure 12 BB line and Figure 10 Similarly, line AA, including the central axis of insertion hole 622b, is in a direction perpendicular to the central axis of the first through hole 622a. Figure 13 The diagram shows a cross-section of the end component 622 and the vortex generating component 624. The vortex generating component 624 is inserted into the end component 622, and is configured to cross the flow direction of the solution in the flow path of the end component.

[0144] In summary, by connecting the electrode section 510 and the suction section 620, the solution attracted by the probe flows into the through-hole 511a of the electrode section 510 through the hollow portion 621a of the tube 621, the first through-hole 622a of the end member 622, and the hollow portion 625a of the gasket 625. Furthermore, in the suction section 620, by arranging a vortex generating member 624 in the flow path of the solution supply, a vortex (Karman vortex) can be generated behind the vortex generating member 624. Thus, the solution generating the Karman vortex can flow into the through-hole 511a of the electrode section 510.

[0145] In addition, the electrolyte detection unit 410A includes: a probe (tube 621, etc.) for conveying a solution drawn from one end to the other end; an eddy current generating member 624 disposed near the other end of the probe; and an electrode portion 510 for generating a potential related to the specified ions (sodium ions, potassium ions, and chloride ions) contained in the solution after passing through the region (first through hole 622a) where the eddy current generating member 624 is disposed.

[0146] As described above, the electrolyte detection unit of the second embodiment includes: a probe for conveying a solution drawn from one end to the other end; an eddy current generating member disposed near the other end of the probe; and an electrode portion for generating a potential related to predetermined ions contained in the solution after passing through the region where the eddy current generating member is disposed. Furthermore, in the second embodiment, the eddy current generating member is disposed by inserting it into the end portion of the probe.

[0147] Therefore, the electrolyte detection unit of the second embodiment can be expected to have the same effect as the first embodiment.

[0148] In the first embodiment, the eddy current generating component is configured by being held between two gaskets. In contrast, in the second embodiment, the eddy current generating component is configured by being inserted into an insertion hole formed in the end component. Therefore, in the electrolyte detection unit of the second embodiment, the eddy current generating component can be reliably and easily configured relative to the center of the flow path.

[0149] (Other implementation methods) The electrolyte detection unit in the second embodiment has a configuration in which the eddy current generating component is disposed on the end component. On the other hand, the electrolyte detection unit in other embodiments has a configuration in which the eddy current generating component is clamped between a pad and the end component.

[0150] Another embodiment of the electrolyte detection unit utilizes a fluororubber liner and a hard rubber end member to clamp the eddy current generating component. With this configuration, the eddy current generating component can be positioned at a desired location without the need for two liners as in the electrolyte detection unit of the first embodiment.

[0151] (Application example) In the above embodiments, a cylindrical shape is listed as a specific shape for the eddy current generating component, but it is not limited to this. The eddy current generating component can also be an elliptical cylinder. Furthermore, the shape of the eddy current generating component is not limited as long as it generates Karman eddy currents.

[0152] Furthermore, from the viewpoint that the generation of eddies increases the ion replacement rate, the electrolyte detection unit can also be configured as follows. The electrolyte detection unit of each of the above embodiments includes: a probe for conveying a solution drawn from one end to the other end; and an electrode section connected to the other end of the probe, generating a potential related to a predetermined ion contained in the solution, causing eddies (e.g., Karman eddies) to be generated in the solution drawn by the probe, and generating a potential related to the predetermined ion contained in the solution where the eddies have been generated.

[0153] According to at least one embodiment described above, the ion replacement rate in the electrolyte detection unit can be improved.

[0154] Several embodiments have been described, but these embodiments are given by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other ways, and various omissions, substitutions, modifications, and combinations of embodiments are possible without departing from the spirit of the invention. These embodiments and their variations are included in the scope and spirit of the invention, as well as in the scope of the invention as described in the claims and its equivalents.

Claims

1. An electrolyte detection unit, wherein, have: The probe delivers the solution drawn from one end to the other. A eddy current generating component is disposed near the other end of the probe; as well as The electrode section generates a potential associated with a specified ion contained in the solution after passing through the region where the eddy current generating component is configured.

2. The electrolyte detection unit according to claim 1, wherein, The vortex generating component is a columnar component arranged intersecting the flow direction of the solution.

3. The electrolyte detection unit according to claim 2, wherein, The column is cylindrical in shape.

4. The electrolyte detection unit according to claim 3, wherein, The electrode section has a flow path for the solution to flow into. The outer diameter of the vortex generating component is smaller than the inner diameter of the flow path.

5. The electrolyte detection unit according to claim 4, wherein, It also includes two pads disposed between the probe and the electrode portion. The eddy current generating component is configured to be held between the two gaskets.

6. The electrolyte detection unit according to claim 5, wherein, The total length of the vortex generating component is less than the outer diameter of each of the two gaskets, but greater than the inner diameter of the flow path.

7. The electrolyte detection unit according to claim 4, wherein, The probe has a terminal component at the other end. The eddy current generating component is configured by inserting it into the end component.

8. The electrolyte detection unit according to claim 7, wherein, The total length of the eddy current generating component is greater than the inner diameter of the flow path disposed on the end component for the eddy current generating component and the inner diameter of the flow path of the electrode portion.

9. The electrolyte detection unit according to claim 7, wherein, The end component is made of hard rubber.

10. The electrolyte detection unit according to claim 4, wherein, It also includes a pad disposed between the probe and the electrode portion. The probe has a terminal component at the other end. The eddy current generating component is configured to be held between the end component and the gasket.

11. The electrolyte detection unit according to claim 10, wherein, The total length of the vortex generating component is less than the outer diameter of the liner and greater than the inner diameter of the flow path.

12. The electrolyte detection unit according to claim 2, wherein, The column is an elliptical cylinder.

13. The electrolyte detection unit according to claim 1, wherein, The eddy current generating component is made of a hard material with high corrosion resistance.

14. The electrolyte detection unit according to claim 13, wherein, The hard material is stainless steel.

15. The electrolyte detection unit according to claim 1, wherein, The electrode portion generates a potential that is proportional to the logarithm of the specified ion concentration.

16. The electrolyte detection unit according to claim 1, wherein, The electrode section has a flow path for the solution to flow into. The electrode portion has an ion exchange membrane corresponding to the specified ion at the position facing the flow path.

17. An automatic analysis device, wherein, have: The reaction disk holds multiple reaction tubes; and An electrolyte measuring unit, comprising an electrolyte detection unit according to any one of claims 1 to 16, measures the concentration of the specified ions by aspirating the solution contained in the reaction tube.

18. An electrolyte detection unit, wherein, have: The probe delivers the solution drawn from one end to the other; and The electrode section, connected to the other end, generates a potential related to a specified ion contained in the solution. The electrolyte detection unit causes the solution attracted by the probe to generate a vortex. The electrode generates a potential associated with a specified ion contained in the solution that generates the eddy current.

19. The electrolyte detection unit according to claim 18, wherein, The eddy current is a Karman eddy current.

20. A method for detecting electrolytes, wherein, The following steps are required: It will transport the solution drawn from one end to the other end; The attracted solution generates a vortex; and A potential associated with a specified ion is generated, the specified ion being contained in the solution in which the eddy current is generated.

21. The electrolyte detection method according to claim 20, wherein, The eddy current is a Karman eddy current.

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