Topical compositions

Abstract

The present invention relates to topical compositions. The present invention relates to topical compositions comprising panthenol, a polysiloxane-based UV filter and a micronized UV filter in specific ratios.

Description

[0001] This application is a divisional application of Chinese patent application No. 201880082393.1, filed on December 17, 2018, entitled “Partial Composition”. Technical Field

[0002] This invention relates to a topical composition comprising panthenol, a polysiloxane-based ultraviolet filter, and a micronized ultraviolet filter in a specific ratio. Background Technology

[0003] Sunscreen products have evolved significantly over the years. Early formulations aimed to protect users from UV-B radiation, as UV-B rays were once considered the leading cause of wrinkles, skin diseases, and skin cancer. However, recent research has shown that UV-A radiation plays an equal or even greater role in sun damage and the development of skin diseases such as lupus and melanoma and non-melanoma skin cancer. Therefore, the current focus is on eliminating as much UVA (320-400 nm) and / or UVB (280-320 nm) light as possible. Consequently, there is a growing demand for sunscreens that offer high SPF (Sun Protection Factor) and high UVA protection while remaining photostable.

[0004] In addition, modern sunscreens require skin-friendly preservatives or preservative enhancers, which can be alternatives to traditional preservatives. Another requirement for sunscreens is improved moisturizing properties and prevention or reduction of skin irritation.

[0005] However, sunscreen products often contain a lot of fats and oils, which, when applied to the skin, especially the fingers, can transfer to surfaces, particularly glass surfaces such as touchscreens, resulting in an oily residue that is highly undesirable to the end consumer. Summary of the Invention

[0006] Therefore, the purpose of this invention is to overcome the shortcomings of the prior art and to develop a sunscreen product containing ultraviolet filters and soothing agents, which overcomes the shortcomings of the prior art.

[0007] Surprisingly, compositions containing large amounts of panthenol combined with polysiloxane-based UV filters and micronized UV filters have been found to exhibit reduced transfer of the composition to glass surfaces.

[0008] Therefore, in one aspect, the present invention relates to a composition comprising panthenol, a polysiloxane-based ultraviolet filter, and a micronized ultraviolet filter, characterized in that the amount (wt%) of panthenol in a portion of the composition is at least equal to (or higher than) the amount of micronized ultraviolet filter and / or polysiloxane-based ultraviolet filter present in the composition.

[0009] In a preferred embodiment, the amount of panthenol in the topical composition according to the invention is at least equal to (or higher than) the amount of the polysiloxane-based ultraviolet filter present in the composition.

[0010] In another preferred embodiment, the amount of panthenol in the local composition according to the invention is at least equal to (or higher than) the amount of micronized UV filters and polysiloxane-based UV filters present in the composition. Detailed Implementation

[0011] The term “local” here is understood to mean the external application of keratin, particularly to the skin, scalp, eyelashes, eyebrows, nails, mucous membranes and hair, preferably the skin.

[0012] Panthenol (INCI), also known as D-panthenol, dextropanthenol, provitamin B5, or (+)-(R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, improves hydration, reduces skin itching and inflammation, improves skin elasticity, and accelerates epidermal wound healing. For example, panthenol is commercially available as D-panthenol at DSM Nutrition Products Europe Ltd.

[0013] As used herein, the term “microparticle” generally refers to a particle size D of less than 200 nm, preferably about 5 nm to about 200 nm, more preferably about 15 nm to about 100 nm. v 50 (Beckmann Coulter).

[0014] Examples of micronized UV filters are micronized insoluble organic UV filters or micronized inorganic UV filters. Examples of micronized insoluble organic UV filters are methylene bis-benzotriazolyltetramethylbutylphenol or terphenyltriazine. Examples of micronized inorganic UV filters are micronized titanium dioxide, micronized zinc oxide, micronized cerium oxide, or micronized iron oxide commonly used in cosmetic applications.

[0015] As used herein, the term "insoluble" refers to properties exhibited at room temperature (i.e., 22℃) in ordinary cosmetic oils (such as benzoic acid C) 12-15The ultraviolet filter is soluble in alkyl esters, propylene glycol, and mineral oils, and its solubility in water is less than 0.05% by weight, preferably less than 0.3% by weight, and most preferably less than 0.01% by weight. According to another embodiment, the micronized ultraviolet filter is a UVA filter, a UVB filter, or a broadband (UVA and UVB) filter.

[0016] According to a preferred embodiment, the micronized ultraviolet filter is a micronized insoluble organic ultraviolet filter.

[0017] According to a preferred embodiment, the micronized ultraviolet filter according to the present invention is an insoluble organic ultraviolet filter having an average particle size distribution D determined by light scattering of less than 200 nm. v 50.

[0018] More preferably, the micronized insoluble organic ultraviolet filter has an average particle size distribution D selected by light scattering (i.e., by photon correlation spectroscopy (PCS)) in the range of 30 to 150 nm, most preferably in the range of 35 to 125 nm, and particularly in the range of 40 to 110 nm. v 50. In a particularly advantageous embodiment, the micronized insoluble organic ultraviolet absorber exhibits a Do in the range of 50 to 80 nm. v 10, D in the range of 75 to 125 nm v 50 and D in the range of 140 to 180 nm v 90, or even more preferably D in the range of 55 to 75 nm. v 10, D in the range of 80 to 110 nm v 50, D in the range of 150 to 175 nm v 90. The particle size given herein is typically determined using Beckman Coulter Delsa Nano S in a suspension of micronized insoluble organic UV absorbers in water, such as ultrapure water (Mili-Q purification), preferably at a concentration of 3 mg / ml.

[0019] According to another embodiment, the local composition comprises a micronized ultraviolet filter as an aqueous dispersion, the aqueous dispersion comprising micronized particles of the micronized ultraviolet filter.

[0020] Preferably, the concentration of the micronized ultraviolet filter in the aqueous dispersion is in the range of 10 to 90 wt%, 20 to 80 wt%, 30 to 70 wt% based on the total weight of the dispersion, more preferably in the range of 40 to 60 wt%, for example in the range of 45 to 55 wt%.

[0021] According to another embodiment, the aqueous dispersion containing the micronized ultraviolet filter additionally contains C 8-16 Alkyl polyglucosides.

[0022] The term "alkyl polyglucan (APG)" refers to a compound with the general formula C2. n H 2+n O(C6H 10 O5) x H is a class of nonionic surfactants, where n is an integer selected from 2 to 22, and x is the average polymerization level of the glucoside moiety (monoglucoside, disoglucoside, triglucoside, oligoglucoside, and polyglucoside). These APGs are widely used in household and industrial applications. They are typically derived from renewable feedstocks, such as glucose derived from corn and fatty alcohols derived from plants. These alkyl polyglucosides typically exhibit an average polymerization level of 1 to 1.7, preferably 1.2 to 1.6, for example 1.4 to 1.6, of the glucoside moiety.

[0023] In all embodiments of the invention, it is particularly advantageous to use a mixture essentially composed of octyl (C8) and decyl (C8). 10 C composed of polyglucosides 8-10 Alkyl polyglucosides. Preferably, such octyl (C8) and decyl (C8) groups are... 10 The polyglucosides also exhibit a ratio in the range of 3:1 to 1:3, preferably in the range of about 2:1 to 1:2, and most preferably in the range of 1.5:1 to 1:1.5. Octyl (C8) monoglucoside and decyl (C8) monoglucoside are also present. 10 The ratio of monoglucosides (% / %, where all % are area % determined by HPLC-MS). Additionally, this type of C... 8-10 The alkyl polyglucoside preferably contains no more than 3% by weight, more preferably no more than 2% by weight, and most preferably no more than 1.5% by weight of C. 12 Alkyl monoglucosides (as determined by HPLC-MS). It is understood that such alkyl polyglucosides are essentially free of any higher-order (i.e., C10) glucosides. 14-16 Alkyl polyglucosides.

[0024] The particularly advantageous C according to the invention 8-10 Alkyl polyglucosides are derived from glucose derived from corn and C8 and C8 polyglucosides derived from coconut oil and palm kernel oil. It is made from 10 fatty alcohols, which are sold, for example, by Shanghai Fine Chemical Co., Ltd. under the trade name GreenAPG 0810 as an aqueous dispersion.

[0025] Preferably, based on the total weight of the aqueous dispersion, this C 8-16 Alkyl polyglucosides or mixtures thereof are present at a concentration of 2 to 15% by weight, preferably 5 to 10% by weight. Preferably, this C... 8-16Alkyl polyglucosides are C 8-10 Alkyl polyglucosides.

[0026] Preferably, in all embodiments of the present invention, the micronized ultraviolet filter is methylenebis-benzotriazolyltetramethylbutylphenol or terphenyltriazine. Most preferably, in all embodiments of the present invention, the ultraviolet filter is micronized methylenebis-benzotriazolyltetramethylbutylphenol.

[0027] Methylenebis-benzotriazolyltetramethylbutylphenol (INCI), also known as MBBT or 2,2'-methylenebis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-phenol, is marketed by DSM Nutritional Products Ltd (PARSOL® MAX) and BASF SE (Tinosorb® M) as an aqueous dispersion containing MBBT and an alkyl polyglucan. MBBT is a broad-spectrum UV filter that filters both UVA and UVB light.

[0028] Triphenyltriazine, also known as 2,4,6-tris([1,1'-biphenyl]-4-yl)-1,3,5-triazine, is a UV filter sold by BASF SE as Tinosorb® A2B.

[0029] Preferably, in all embodiments of the invention, the polysiloxane-based ultraviolet filter in the local composition has benzene methylene malonate type chromophore residues.

[0030] Even more preferably, the polysiloxane-based ultraviolet filter according to the present invention is a compound according to formula Ia or Ib: Ia Ib in X is either R or A; A is selected from formula IIa, IIb, or IIc: IIa IIb IIc R represents hydrogen, C represents... 1-6 -alkyl or phenyl; R 1 and R 2 Each is independently hydrogen, hydroxyl, C 1-6 -alkyl or C 1-6 -alkoxy group; R 3 C1-6 -alkyl; R 4 It is hydrogen or C 1-6 -alkyl; R 5 and R 6 Each is independently hydrogen or C 1-6 -alkyl; r is between 0 and 250; s is between 0 and 20; r + s is at least 3; t is between 0 and 10; v is between 0 and 10; v + t is at least 3; and n is 1 to 6; The prerequisite is that when s is 0, at least one X is A.

[0031] Term "C" 1-6 "-alkyl" refers to groups such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, isobutyl, pentyl, and neopentyl. The term "C"... 1-6 "-alkoxy" refers to the corresponding alkoxy group.

[0032] In all embodiments of the present invention, R is preferably methyl.

[0033] Residue R 1 and R 2 Preferably hydrogen, methoxy, or ethoxy, more preferably hydrogen, or R 1 and R 2 One of them is hydrogen, and the other is methyl, methoxy, or ethoxy.

[0034] Residue R 3 Preferably methyl or ethyl, more preferably ethyl.

[0035] Preferably, R 4 For hydrogen or methyl, R 5 and R 6 It is hydrogen, and n is 1.

[0036] Polysiloxane compounds of group A having general formulas IIa and IIb, and their preparation, are described in European patent application EP-A0538431. These polysiloxane compounds are the most preferred.

[0037] Polysiloxane compounds of group A having general formula IIc and their preparation are described in European patent application EP-A0358584.

[0038] In linear polysiloxane compounds according to formula Ia, residue A carrying a chromophore can be attached to the end group of the polysiloxane (X=A), or can be statistically distributed on the polymer.

[0039] A linear polysiloxane compound with a statistically distributed chromophore residue A is preferred. The preferred polysiloxane compound has at least one unit carrying a chromophore residue (s=1), preferably, s has a value of about 2 to about 10, more preferably a statistical average of about 4. The number r of other siloxane units present in the polysiloxane compound is preferably about 5 to about 150, more preferably a statistical average of about 60.

[0040] In terms of cosmetic performance, polysiloxane compounds are preferred, wherein 20% or less, preferably less than 10%, of all siloxane units are units carrying chromophore residues.

[0041] The ratio of the polysiloxane unit having chromophore residue A of formula IIa to the polysiloxane unit having chromophore residue A of formula IIb is not important. The ratio can be from about 1:1 to about 19:1, preferably from about 2:1 to about 9:1, and more preferably from about 4:1.

[0042] Polysiloxane compounds Ia or Ib, where A is a residue of formula IIa or IIb, can be prepared by the silanization reaction of the corresponding benzenemethylene malonate according to the following reaction scheme, as described in EP-B0538431: Among them, R 1 R 2 and R 3 As defined above.

[0043] The silanization of 4-(2-propynyloxy)phenylmethylene diethyl ester can be carried out using known procedures for the addition of hydrogen-bonded silicon to a group containing an aliphatic unsaturated group. This reaction is typically catalyzed by platinum group metals or their complexes. Examples of catalysts that can be used are carbon-supported platinum, chloroplatinic acid, platinum acetylacetonate, complexes of platinum compounds with unsaturated compounds (e.g., alkenes and divinyldisiloxanes), complexes of platinum compounds supported on inorganic substrates, and complexes of rhodium and palladium compounds. The addition reaction can be carried out under reduced pressure, atmospheric pressure, or high pressure. Solvents such as toluene or xylene can be used in the reaction mixture, although the presence of a solvent is not essential. Higher reaction temperatures are also preferred, for example, from about 50°C to about 150°C.

[0044] Compounds of general formula Ia are particularly preferred, wherein X represents methyl, A represents a group of formula IIa or IIb. R represents methyl. R 1 and R 2Indicates hydrogen, methoxy or ethoxy, or R 1 and R 2 One of them is hydrogen, and the other is methyl, methoxy, or ethoxy. R 3 Indicates methyl or ethyl. R 4 Indicates hydrogen or methyl. R 5 and R 6 It represents hydrogen. r ranges from approximately 5 to 150. s is approximately 2 to approximately 10, and The value of n is 1.

[0045] The most preferred are linear polysiloxanes of general formula Ia, wherein X represents methyl, A represents a group of formula IIa or IIb. R represents methyl. R 1 and R 2 It represents hydrogen. R 3 It represents ethyl, R 4 It represents hydrogen. R 5 and R 6 It represents hydrogen. r is the statistical average of approximately 60. s is the statistical average of approximately 4, and, The value of n is 1.

[0046] In all embodiments of the present invention, these most preferred polysiloxane-based UV filters are polysiloxane-15 (INCI), which is marketed by DSM Nutrition Ltd under the trade name PARSOL. ® SLX is available for retail sale.

[0047] In all embodiments of the invention, the amount of panthenol present in a local composition according to the invention, based on the total weight of the composition, is advantageously selected from the range of 0.1 wt% to 10 wt%, preferably from 0.5 wt% to 8 wt%, more preferably from 1 wt% to 7 wt%, and most preferably from 2 wt% to 6 wt%. A further preferred range based on the total weight of the composition is 1 wt% to 6 wt% or 2 wt% to 6 wt% of panthenol.

[0048] In all embodiments of the invention, the amount of the micronized ultraviolet filter (based on the active substance), preferably methylenebis-benzotriazolyltetramethylbutylphenol or terphenyltriazine, most preferably methylenebis-benzotriazolyltetramethylbutylphenol, present in the local composition according to the invention, is advantageously selected from 0.1 to 9% by weight, preferably from 0.5 to 7% by weight, more preferably from 1 to 6% by weight, and most specifically from 1 to 5% by weight, based on the total weight of the composition. Further preferred ranges are 0.5 to 6% by weight, 1 to 5% by weight, and 1 to 3% by weight, based on the total weight of the composition.

[0049] In all embodiments of the invention, the amount of the polysiloxane-based UV filter, preferably a polysiloxane-based UV filter having phenylmethylene malonate chromophore residues (e.g., most preferably polysiloxane-15), in the local composition according to the invention, is advantageously selected from the range of 0.1 wt% to 9 wt%, preferably from 0.5 wt% to 7 wt%, more preferably from 1 wt% to 6 wt%, and most preferably from 1 wt% to 5 wt%. Further suitable ranges would be from 1 wt% to 7 wt% or from 2 wt% to 4 wt%.

[0050] A particularly advantageous topical composition according to the invention comprises 2 to 6 wt% panthenol, 1 to 3 wt% methylenebis-benzotriazolyltetramethylbutylphenol (based on the active substance) and 2 to 4 wt% polysiloxane-15 (all amounts are based on the total weight of the composition).

[0051] One embodiment of the present invention relates to a method of using a micronized ultraviolet filter described and defined herein in a local composition of the present invention to reduce local composition transfer to a glass or plastic surface.

[0052] In one specific embodiment of the invention, a method is involved in using panthenol, micronized UV filters, and polysiloxane-based UV filters as described and defined herein in a localized composition to reduce transfer of the localized composition to a glass or plastic surface. In a particularly advantageous embodiment, the amount of panthenol in the localized composition is at least equal to (or higher than) the amount of micronized UV filters and / or polysiloxane-based UV filters.

[0053] In a particularly preferred embodiment, the present invention relates to a method of using 2 to 6 wt% panthenol, 1 to 3 wt% methylenebis-benzotriazolyltetramethylbutylphenol (based on the active substance), and 2 to 4 wt% polysiloxane-15 in a topical composition to reduce the transfer of the topical composition to a glass or plastic surface, provided that the amount of panthenol in the topical composition is at least equal to (or higher than) the amount of polysiloxane-15 and / or the amount of methylenebis-benzotriazolyltetramethylbutylphenol.

[0054] In another embodiment, the present invention relates to the use of panthenol, micronized UV filters, and polysiloxane-based UV filters as described and defined herein for reducing the transfer of fats and oils contained in a localized composition to surfaces (e.g., glass or plastic surfaces, such as touchscreens). In a particularly advantageous embodiment, the amount of panthenol in the localized composition is at least equal to (or higher than) the amount of micronized UV filters and / or polysiloxane-based UV filters.

[0055] In a particularly preferred embodiment, the present invention relates to the use of 2 to 6 wt% panthenol, 1 to 3 wt% methylenebis-benzotriazolyltetramethylbutylphenol (based on the active substance), and 2 to 4 wt% polysiloxane-15, for reducing the transfer of fats and oils contained in a local composition to surfaces, such as, in particular, glass or plastic surfaces (such as touch screens), provided that the amount of panthenol in the local composition is at least equal to (or higher than) the amount of polysiloxane-15 and / or the amount of methylenebis-benzotriazolyltetramethylbutylphenol.

[0056] In an additional embodiment, the present invention relates to a method for reducing the transfer of fats and / or oils to surfaces (particularly glass or plastic surfaces, such as touchscreens), the method comprising adding panthenol, micronized ultraviolet filters, and polysiloxane-based ultraviolet filters as described and defined herein, to a local composition comprising such fats and oils according to the invention. In a particularly advantageous embodiment, the amount of panthenol in the local composition is at least equal to (or higher than) the amount of micronized ultraviolet filters and / or polysiloxane-based ultraviolet filters.

[0057] In another particularly advantageous embodiment, the present invention relates to a method for reducing the transfer of fats and / or oils to surfaces (e.g., glass or plastic surfaces, such as touchscreens), the method comprising adding 2 to 6 wt% panthenol, 1 to 3 wt% methylenebis-benzotriazolyltetramethylbutylphenol (based on the active substance), and 2 to 4 wt% polysiloxane-15 to a topical composition comprising such fats and oils, provided that the amount of panthenol in the topical composition is at least equal to (or higher than) the amount of polysiloxane-15 and / or the amount of methylenebis-benzotriazolyltetramethylbutylphenol.

[0058] In all embodiments of the invention, preferred local compositions are emulsions containing an oil phase and an aqueous phase, such as, in particular, O / W, W / O, Si / W, W / Si, O / W / O, W / O / W multiple emulsions or Pickering emulsions. Based on the total weight of the composition, the amount of the oil phase (i.e., the phase containing all oils and fats) present in such an emulsion is preferably at least 10% by weight, for example, in the range of 10 to 60% by weight, preferably in the range of 15-50% by weight, and most preferably in the range of 15-40% by weight.

[0059] In another embodiment, the present invention relates to a topical composition according to the embodiments described herein used as a sunscreen agent, and also to the use of a topical composition according to the embodiments described herein as a sunscreen agent.

[0060] In addition to micronized ultraviolet filters, especially micronized methylene bis-benzotriazolyl tetramethylbutylphenol or terphenyltriazine and polysiloxane-based ultraviolet filters, other ultraviolet filters may also be present in the partial compositions according to the invention. These ultraviolet filters are commercially available ultraviolet filter substances, such as (INCI name) phenylbenzimidazole sulfonic acid, 3-benzylmethylene camphor, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, humosalilate, ethylhexyl triazine, zinc oxide, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylhexylbutamidotriazine, benzophenone-3, titanium dioxide, butyl methoxydibenzoylmethane, disodium phenyldibenzimidazole tetrasulfonate, and diethylaminohydroxybenzoyl hexyl benzoate, but are not limited to these substances. Preferably, the topical composition according to the invention comprises at least octyl cyanobenzyl acrylate, ethylhexyl salicylate, and butyl methoxydibenzoylmethane as other ultraviolet filters.

[0061] Since the topical compositions according to the invention are intended for topical application, they contain a physiologically acceptable medium, i.e., a medium compatible with keratinous substances (e.g., skin, mucous membranes, and keratin fibers). In particular, the physiologically acceptable medium is a cosmetically acceptable carrier.

[0062] The term "cosmetically acceptable carrier" refers to all carriers and / or excipients and / or diluents that are routinely used in cosmetic compositions.

[0063] Preferred topical compositions according to the present invention are skin care preparations, decorative preparations, and functional preparations.

[0064] Examples of skin care preparations include, in particular, photoprotective preparations, anti-aging preparations, preparations for treating photoaging, body oils, body lotions, body gels, care creams, skin ointments, skin powders, moisturizing gels, moisturizing sprays, facial and / or body moisturizers, skin tanning preparations (i.e., compositions for artificial / sun-free tanning and / or darkening of human skin), such as self-tanning creams and skin brightening preparations.

[0065] Examples of cosmetic preparations include, in particular, lipsticks, eyeshadows, mascaras, dry and wet cosmetic formulations, blushes and / or face powders.

[0066] Examples of functional formulations are cosmetic or pharmaceutical compositions containing active ingredients, such as hormone formulations, vitamin formulations, plant extract formulations, anti-aging formulations, and / or antimicrobial (antibacterial or antifungal) formulations, but not limited to these.

[0067] In one specific embodiment, the local composition according to the invention is a photoprotective agent (sunscreen product), such as sunscreen lotion, sunscreen gel, sunscreen cream, sunscreen oil, ultraviolet blocker, or day cream with SPF (Sun Protection Factor). Of particular interest are sunscreens, sunscreen gels, sunscreen lotions, and sunscreen formulations.

[0068] The topical compositions according to the invention may be in the form of a suspension or dispersion in a solvent or fatty substance, or alternatively may be in the form of an emulsion or microemulsion (especially oil-in-water (O / W-) or water-in-oil (W / O-), siloxane-in-water (Si / W-) or siloxane-in-water (W / Si-), PIT emulsion, multiple emulsion (e.g., oil-in-water-in-oil (O / W / O-) or water-in-oil-in-water (W / O / W-)), Pickering emulsion, hydrogel, alcohol gel, lipid gel, single-phase or multi-phase solution or capsule dispersion or other common forms, which may also be applied by pen, as a face mask or as a spray.

[0069] The local compositions according to the invention are advantageously present in the form of an O / W emulsion comprising an oil phase dispersed in an aqueous phase in the presence of an oil-in-water (O / W) emulsifier. The preparation of such O / W emulsions is well known to those skilled in the art and is illustrated in the examples.

[0070] In an advantageous embodiment, the O / W emulsifier according to the invention is a phosphate ester emulsifier. The term phosphate ester emulsifier refers to a phosphate ester emulsifier of formula (II). Equation (II) Where R 5 R 6 and R 7 It can be hydrogen, an alkyl group having 1 to 22 carbons, preferably 12 to 18 carbons; or an alkoxylated alkyl group having 1 to 22 carbons, preferably 12 to 18 carbons, and having 1 mole or more, preferably 2 to 25 moles, most preferably 2 to 12 moles of ethylene oxide, wherein the precursor condition is R. 5 R 6 and R 7 At least one of them is an alkyl or alkoxylated alkyl group as defined above, but having at least 6 alkyl carbons in the alkyl or alkoxylated alkyl group.

[0071] Preferred is a monoester in which R 5 and R 6 For hydrogen, R 7 Alkoxylated fatty alcohols selected from alkyl groups with 10 to 18 carbon atoms and 2 to 12 moles of ethylene oxide with 10 to 18 carbon atoms. Particularly preferred phosphate ester emulsifiers are C... 8-10 Alkyl ethyl phosphate, C 9-15 Alkyl phosphate, cetearyl alcohol polyether-2 phosphate, cetearyl alcohol polyether-5 phosphate, cetearyl alcohol polyether-8 phosphate, cetearyl alcohol polyether-10 phosphate, cetyl phosphate, C6-10 alkanol polyether-4 phosphate, C 12-15 Alkyl alcohol polyether-2-phosphate, C 12-15 Alkyl alcohol polyether-3 phosphate, DEA-cetearyl alcohol polyether-2 phosphate, DEA-cetyl phosphate, DEA-oleyl alcohol polyether-3 phosphate, cetyl phosphate potassium, decanol polyether-4 phosphate, decanol polyether-6 phosphate, and lauryl alcohol polyether-4 phosphate. A specific phosphate emulsifier according to the invention is cetyl phosphate potassium, for example, DSM Nutrition Products Ltd. Kaiseraugst with Amphisol. ® K is commercialized.

[0072] Other suitable O / W emulsifiers according to the invention include PEG-30 dihydroxystearate, PEG-4 dilaurate, PEG-8 dioleate, PEG-40 sorbitan peroleate, PEG-7 glyceryl cocoate, PEG-20 apricot oil glyceryl ester, PEG-25 hydrogenated castor oil, glyceryl stearate (and) PEG-100 stearate, PEG-7 olive oil ester, PEG-8 oleate, PEG-8 laurate, PEG-60 apricot oil glyceryl ester, PEG-20 methyl glucose sesquistearate, PEG-40 stearate, PEG-100 stearate, PEG -80 Sorbitol Laurate, Stearyl Ether-2, Stearyl Ether-12, Oleyl Ether-2, Cetyl Ether-2, Laureth-4, Oleyl Ether-10, Oleyl Ether-10 / PEG 10 Oleyl Ether, Cetyl Ether-10, Isocerocetyl Ether-20, Cetearyl Stearyl Ether-20, Oleyl Ether-20, Stearyl Ether-20, Stearyl Ether-21, Cetyl Ether-20, Isocerocetyl Ether-20, Laureth-23, Stearyl Ether-100, Glyceryl Stearate Citrate, Glyceryl Stearate (Self-emulsifying), Stearic Acid, Stearate Salt, Polyglycerol-3-methylglucose distearate. Other suitable emulsifiers include sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, lauryl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate, and hydrated polyisobutylene. In addition, one or more synthetic polymers can be used as emulsifiers. For example, PVP eicosene copolymers, acrylates / C 10-30 Alkyl acrylate crosspolymers, acrylate / stearyl ether-20 methacrylate copolymers, PEG-22 / dodecyl glycol copolymers, PEG-45 / dodecyl glycol copolymers, and mixtures thereof.

[0073] Another particularly suitable class of O / W emulsifiers is nonionic self-emulsifying systems derived from olive oil, such as olive oil cetyl ester and dehydrated sorbitan olive oil ester (chemical composition: dehydrated sorbitan ester and cetearyl ester of olive oil fatty acids) sold under the trade name OLIVEM 1000 (INCI name).

[0074] Other suitable options are commercially available polymer emulsifiers, such as hydrophobically modified polyacrylic acids like acrylate / C10-30 alkyl acrylate crosspolymers, which are marketed under the trade name Pemulen. ® TR-1 and TR-2 are commercially available from Noveon.

[0075] Another particularly suitable class of emulsifiers are polyglycerol esters or diesters of fatty acids, also known as polyglycerol esters / diesters (i.e., polymers in which one or more fatty acids are combined with polyglycerol through esterification), for example, commercially available in Evonik as Isolan GPS [INCI name: polyglycerol-4-diisostearate / polyhydroxystearate / sebacate (i.e., diesters of isostearic acid, polyhydroxystearate and sebacate mixed with polyglycerol-4)] or in Cognis as Dehymuls PGPH (INCI polyglycerol-2-dihydroxystearate).

[0076] In addition, suitable options are polyalkylene glycol ethers, such as Brij 72 (polyoxyethylene (2) stearyl alcohol ether) or Brij 721 (polyoxyethylene (21) stearyl alcohol ether), which are available, for example, at Croda.

[0077] Based on the total weight of the composition, at least one of the O / W emulsifiers or Si / W emulsifiers is preferably used in an amount from 0.5% to 10% by weight, for example, particularly from 0.5% to 5% by weight, for example, most particularly from 0.5% to 4% by weight.

[0078] Suitable W / O or W / Si emulsifiers are polyglycerol-2-dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, cetyl polydimethylsiloxane copolyol, polyglycerol-3-diisostearate of oleic acid / isostearic acid, polyglyceryl-6-hexaricinolate, polyglycerol-4-oleate, polyglycerol-4-oleate / PEG-8 propylene glycol cocoate, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallow, potassium ricinoleate, sodium oleate, and mixtures thereof. Other suitable W / Si emulsifiers are lauryl polyglycerol-3 polydimethylsiloxane and / or PEG-9 polydimethylsiloxane and / or cetyl PEG / PPG-10 / 1 dimethylsiloxane and / or PEG-12 dimethylsiloxane crosspolymer and / or PEG / PPG-18 / 18 dimethylsiloxane. Based on the total weight of the composition, the at least one W / O emulsifier is preferably used in an amount of about 0.001% to 10% by weight, more preferably 0.2% to 7% by weight.

[0079] The local compositions according to the invention also advantageously comprise at least one co-surfactant, for example, selected from the group consisting of monoglycerides and diglycerides and / or fatty alcohols. Based on the total weight of the composition, the co-surfactant is typically used in an amount selected from 0.1% by weight to 10% by weight, particularly 0.5% by weight to 7% by weight, and most particularly 1% by weight to 5% by weight. Particularly suitable co-surfactants are selected from a list of alkyl alcohols, such as cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol (Lanette O), stearyl alcohol (Lanette 18), behenyl alcohol (Lanette 22), glyceryl stearate, glyceryl myristate (Estol 3650), hydrogenated glyceryl cocoate (Lipocire Na10), and mixtures thereof.

[0080] The compositions according to the invention in the form of an O / W emulsion can be prepared, for example, in all formulations for O / W emulsions, such as whey, lotion, or cream, and according to conventional methods. The compositions as the subject of this invention are intended for topical application and can particularly constitute dermatological or cosmetic compositions, for example, intended to protect human skin from the adverse effects of ultraviolet radiation (anti-wrinkle, anti-aging, moisturizing, sun protection, etc.).

[0081] According to an advantageous embodiment of the invention, the composition constitutes a cosmetic composition and is intended for topical application to the skin.

[0082] Finally, the subject of this invention is a method for cosmetic treatment of keratinized material (e.g., particularly skin), wherein the composition as defined above is applied to said keratinized material (e.g., particularly skin). This method is particularly suitable for protecting the skin from the adverse effects of ultraviolet radiation, such as, in particular, sunburn and / or photoaging.

[0083] According to the present invention, the compositions may contain other ingredients, such as ingredients for brightening and preventing tanning; ingredients for treating pigmentation; ingredients for preventing or reducing acne, wrinkles, folds, atrophy, and / or inflammation; chelating agents and / or isolating agents; anti-fat and weight-loss (e.g., phytanoic acid), firming, moisturizing and revitalizing, sun-protective, and soothing ingredients; and pharmaceuticals for improving elasticity and the skin barrier, and / or other UV-filtering substances and carriers and / or excipients or diluents conventionally used in topical compositions. Unless otherwise specified, the excipients, additives, diluents, etc., mentioned below are applicable to the topical compositions according to the present invention. The necessary amounts of cosmetic adjuvants and additives and dermatological adjuvants and additives can be readily determined by a person skilled in the art based on the desired product. Additional ingredients may be added to the oil phase, aqueous phase, or separately, as appropriate. Those skilled in the art can readily adjust the manner of addition.

[0084] In some cases, the useful cosmetic active ingredients described in this article may provide more than one benefit or work through more than one mechanism of action.

[0085] The local compositions according to the invention may also contain useful cosmetic adjuvants and additives, such as preservatives / antioxidants, fatty substances / oils, water, organic solvents, siloxanes, thickeners, emulsifiers, sunscreens, defoamers, moisturizers, cosmetic ingredients such as fragrances, surfactants, fillers, blocking agents, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidifiers or alkalizers, dyes, pigments / coloring agents, abrasives, absorbents, essential oils, skin receptors, astringents, defoamers, pigments or nanopigments, such as those suitable for providing photoprotection by physically blocking ultraviolet radiation, or any other ingredients commonly formulated in cosmetic compositions. These cosmetic ingredients commonly used in the skincare industry and applicable to the compositions of this invention are described, for example, in the International Cosmetic Ingredient Dictionary & Handbook of the Personal Care Products Council (http: / / www.personalcarecouncil.org), which is accessible online via INFO BASE (http: / / online.personalcarecouncil.org / jsp / Home.jsp), but are not limited thereto.

[0086] The necessary amounts of cosmetic adjuvants and additives and dermatological adjuvants and additives, depending on the desired product, can be readily selected by those skilled in the art and will be illustrated in the examples, but are not limited thereto.

[0087] Of course, those skilled in the art will carefully select one or more of the above-mentioned optional additional compounds and / or their amounts so that the advantageous properties inherently associated with the combination according to the invention are not or substantially not adversely affected by the anticipated addition of one or more compounds.

[0088] The local compositions according to the invention generally have a pH in the range of 3 to 10, preferably in the range of 4 to 8, and most preferably in the range of 4 to 7. The pH can be readily adjusted as needed using a suitable acid (e.g., citric acid) or base (e.g., NaOH) according to standard methods in the art.

[0089] The topical composition according to the invention may further comprise one or more skin-soothing and softening emollients. As an example, the emollient may be dioctyl carbonate or C... 12-15Alkyl parabens. Other emollients include siloxanes (dimethicone, cyclic polymethylsiloxane), vegetable oils (grape seed, sesame seed, jojoba oil, etc.), butters (cocoa butter, shea butter), alcohols (stearyl alcohol, cetyl alcohol), and petrolatum derivatives (petrolatum oil, mineral oil).

[0090] The cosmetic compositions according to the invention advantageously contain preservatives or preservative enhancers. Preferably, the additional preservatives and preservative enhancers are selected from the group consisting of phenoxyethanol, ethylhexylglycerin, hydroxyacetophenone, glyceryl caprylate, ethylene glycol caprylate, 1,2-hexanediol, propanediol, propylene glycol, and mixtures thereof. When present, the preservatives and preservative enhancers are preferably used in amounts of 0.01% to 2% by weight, more preferably 0.05% to 1.5% by weight, and most preferably 0.1% to 1.0% by weight, based on the total weight of the composition. Particularly preferred is that the cosmetic compositions according to the invention do not contain any additional / other preservatives, such as parabens and / or methylisothiazolinones.

[0091] To further illustrate certain aspects of the invention, the invention also provides the following non-limiting embodiments: Embodiment 1. A topical composition comprising panthenol, a micronized ultraviolet filter, and a polysiloxane-based ultraviolet filter, characterized in that the amount of panthenol in the topical composition is at least equal to (or higher than) the amount of the polysiloxane-based ultraviolet filter and / or the amount of the micronized ultraviolet filter.

[0092] Embodiment 2. The local composition according to Embodiment 1, wherein the micronized ultraviolet filter has an average particle size distribution D determined by light scattering of less than 200 nm. v 50.

[0093] Embodiment 3. The local composition according to Embodiment 1 or 2, wherein the micronized ultraviolet filter is a micronized insoluble organic ultraviolet filter.

[0094] Embodiment 4. A local composition according to any one of Embodiments 1 to 3, wherein the micronized ultraviolet filter is used as an aqueous dispersion of particles containing the micronized ultraviolet filter.

[0095] Embodiment 5. The topical composition according to Embodiment 4, wherein the aqueous dispersion containing the micronized ultraviolet filter additionally contains C 8-16 Alkyl polyglucosides.

[0096] Embodiment 6. A topical composition according to any one of Embodiments 1 to 5, wherein the micronized ultraviolet filter is methylene bis-benzotriazolyltetramethylbutylphenol or terphenyltriazine.

[0097] Embodiment 7. A topical composition according to any one of Embodiments 1 to 6, wherein the polysiloxane-based ultraviolet filter is a compound according to formula Ia or Ib: Ia Ib in X is either R or A; A is selected from formula IIa, IIb, or IIc: IIa IIb IIc; R represents hydrogen, C represents... 1-6 -alkyl or phenyl; R 1 and R 2 Each is independently hydrogen, hydroxyl, C 1-6 -alkyl or C 1-6 -alkoxy group; R 3 C 1-6 -alkyl; R 4 It is hydrogen or C 1-6 -alkyl; R 5 and R 6 Each is independently hydrogen or C 1-6 -alkyl; r is between 0 and 250; s is between 0 and 20; r + s is at least 3; t is between 0 and 10; v is between 0 and 10; v + t is at least 3; and n is 1 to 6; The prerequisite is that when s is 0, at least one X is A.

[0098] Embodiment 8. A topical composition according to any one of Embodiments 1 to 7, wherein the polysiloxane-based ultraviolet filter is polysiloxane-15.

[0099] Embodiment 9. A partial composition according to any one of Embodiments 1 to 8, wherein the amount of the micronized ultraviolet filter (based on the active substance) is selected from the range of 0.1% to 9% by weight, preferably from 0.5% to 7% by weight, more preferably from 1% to 6% by weight, and most preferably from 1% to 5% by weight, based on the total weight of the composition.

[0100] Embodiment 10. A topical composition according to any one of Embodiments 1 to 9, wherein panthenol is present in the topical composition in an amount selected from 0.1% to 10% by weight, preferably from 0.5% to 8% by weight, more preferably from 1% to 7% by weight, and most preferably from 2% to 6% by weight, based on the total weight of the composition.

[0101] Embodiment 11. A topical composition according to any one of Embodiments 1 to 10, wherein, based on the total weight of the composition, the polysiloxane-based ultraviolet filter is present in the topical composition in an amount selected from 0.1 wt% to 9 wt%, preferably from 0.5 wt% to 7 wt%, more preferably from 1 wt% to 6 wt%, and most preferably from 1 wt% to 5 wt%.

[0102] Embodiment 12. A partial composition according to any one of Embodiments 1 to 11, wherein the composition is in the form of an oil-in-water (O / W) emulsion comprising an oil phase dispersed in an aqueous phase in the presence of an oil-in-water (O / W) emulsifier.

[0103] Example 13. A topical composition according to any one of Examples 1 to 12, wherein the topical composition further comprises butyl methoxydibenzoylmethane, octyl cyanobenzyl acrylate and ethylhexyl salicylate.

[0104] Implementation Method 14. Use of panthenol, micronized ultraviolet filters and polysiloxane-based ultraviolet filters in a local composition for reducing the transfer of the local composition to a glass or plastic surface.

[0105] Implementation Method 15. A method for reducing the transfer of fats and / or oils to surfaces, such as glass or plastic surfaces, the method comprising adding panthenol, micronized ultraviolet filters, and polysiloxane-based ultraviolet filters to a local composition containing the fats and oils.

[0106] The following examples are provided to further illustrate the compositions and effects of the present invention. These examples are merely illustrative and are not intended to limit the scope of the invention in any way.

[0107] Experimental Section The formulations (O / W emulsions) described in Table 1 have been prepared according to standard methods in the art.

[0108] Then, use the sponge test as described below to test transfer resistance: - Cut a piece of sponge fabric into small pieces of 7.5cm x 2.5cm; - Weight of the tare (calibrated) sponge sample; - Apply 400 mg of cream and distribute it evenly over all 7.5 x 2.5 cm of the sponge surface; - The sponge of the sample coated with the weighing belt; - Peel and calibrate microscope slides (glass plates); - Place the microscope slide (glass plate) on top of the sponge with a pressure of 500 g for 10 seconds; - Weigh the amount of cream transferred to the glass plate. - Repeat the test 10 times for each formulation to obtain the average value for each formulation.

[0109] The results are listed in Table 1.

[0110] Table 1 Table 2 shows that adding a relatively large amount of D-panthenol to the composition containing a polysiloxane-based UV filter (polysiloxane-15) and methylenebis-benzotriazolyltetramethylbutylphenol significantly reduced the amount of cream transferred to the glass surface.

Claims

1. A topical composition comprising panthenol, a micronized UV filter methylene bis-benzotriazolyl tetramethylbutylphenol and a polysiloxane-based UV filter, characterized in that Based on the total weight of the composition, panthenol is present in the topical composition in an amount selected from 2% to 6% by weight, and the amount of panthenol in the topical composition is equal to or higher than the amount of the polysiloxane-based ultraviolet filter.

2. The topical composition according to claim 1, wherein the amount of panthenol in the topical composition is equal to or higher than the total amount of the polysiloxane-based UV filter and the micronized UV filter present in the composition.

3. The topical composition according to claim 1 or 2, wherein the micronized UV filter has an average particle size distribution D by light scattering of less than 200 nm v 50.

4. The topical composition according to claim 1 or 2, wherein the micronized ultraviolet filter is used as an aqueous dispersion of particles containing the micronized ultraviolet filter.

5. The topical composition of claim 4, wherein the aqueous dispersion comprising a micronized ultraviolet filter additionally comprises C 8-16 Alkyl polyglucosides.

6. The topical composition according to claim 1 or 2, wherein the polysiloxane-based ultraviolet filter is a compound according to formula Ia or Ib: Ia Ib in X is either R or A; A is selected from formula IIa, IIb, or IIc: IIa IIb IIc; R is hydrogen, C 1-6 - alkyl or phenyl; R 1 and R 2 Each is independently hydrogen, hydroxyl, C 1-6 -alkyl or C 1-6 -alkoxy group; R 3 is C 1-6 -alkyl; R 4 is hydrogen or C 1-6 -alkyl; R 5 and R 6 Each is independently hydrogen or C 1-6 -alkyl; r is between 0 and 250; s is between 0 and 20; r + s is at least 3; t is between 0 and 10; v is between 0 and 10; v + t is at least 3; and n is 1 to 6; The prerequisite is that when s is 0, at least one X is A.

7. The topical composition according to claim 1 or 2, wherein the polysiloxane-based ultraviolet filter is polysiloxane-15.

8. The topical composition according to claim 1 or 2, wherein the amount of the micronized ultraviolet filter based on the active substance is selected from the range of 0.1% by weight to 9% by weight, based on the total weight of the composition.

9. The topical composition according to claim 1 or 2, wherein panthenol is present in the topical composition in an amount selected from 3% to 6% by weight, based on the total weight of the composition.

10. The topical composition according to claim 1 or 2, wherein the polysiloxane-based ultraviolet filter is present in the topical composition in an amount selected from 0.1% by weight to 9% by weight, based on the total weight of the composition.

11. The partial composition according to claim 1 or 2, wherein the composition is in the form of an oil-in-water emulsion comprising an oil phase dispersed in an aqueous phase in the presence of an oil-in-water emulsifier.

12. The topical composition according to claim 1 or 2, wherein the topical composition further comprises butyl methoxydibenzoylmethane, octyl cyanobenzyl acrylate and ethylhexyl salicylate.

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