A cooling and detumescent plaster for treating sprains and a preparation method thereof

Abstract

The present invention provides a cooling and detumescence paste for treating sprains and its preparation method. Through the synergistic effect of multiple traditional Chinese medicines such as Trogopterus dung, Eupolyphaga seu Steleophaga, Notoginseng powder, Prunus persica, Carthamus tinctorius, Olibanum, Myrrha, Gardenia jasminoides Ellis, Rheum palmatum, Albizia julibrissin Durazz. etc. under a specific weight ratio, the present invention achieves the rapid subsidence of swelling, heat, pain and the relief of pain in the new injury stage of acute soft tissue injury. The present invention adopts the process of separately treating the powdery drug and the liquid matrix and then mixing them, which maximally retains the active ingredients of the drug. The prepared cooling and detumescence paste has uniform texture, good spreadability, is easy to absorb, and the preparation method is simple, suitable for industrial production. After being clinically verified for more than 40 years, when this product is applied to the damaged local area for those with traumatic injury, swelling and pain due to blood stasis, and difficult-to-eliminate purplish bruises, it can rapidly detumesce and relieve pain, with satisfactory curative effects, and no obvious toxic and side effects are found.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a cooling and swelling-reducing ointment for treating sprains and its preparation method. Background Technology

[0002] With increased physical activity in daily life and work, and the frequent occurrence of accidents, acute soft tissue injuries, such as joint sprains, muscle strains, and bruises, have become common and frequently occurring clinical conditions. These injuries, in their early stages, within the first week after the injury, are typically referred to as new injuries. The pathological characteristics of new injuries include local blood stasis and meridian blockage, leading to swelling, pain, and functional impairment. Simultaneously, the stagnation of blood often generates heat, resulting in not only limited function but also severe pain at the injury site, as well as redness, increased skin temperature, and other red, swollen, hot, and painful symptoms due to the heat from the blood stasis. Therefore, the treatment principle for early-stage acute soft tissue injuries should focus on promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain, supplemented appropriately with cooling herbs to clear heat and stagnation, thereby achieving rapid swelling reduction, quick pain relief, and promoting injury repair. Traditional Chinese medicine orthopedics has a theory that if bones do not heal, swelling will not subside, and if swelling does not subside, bones will not heal. This emphasizes that only when blood and qi flow smoothly and swelling subsides quickly can favorable conditions be created for subsequent tissue repair and even fracture healing.

[0003] Currently, the market offers a wide variety of topical preparations for treating sprains and bruises, including plasters, liniments, aerosols, and ointments. However, existing products generally suffer from the following problems: First, some traditional blood-activating and stasis-removing plasters are warming and drying in nature. When used on newly injured areas with redness, swelling, heat, and pain, they may actually exacerbate the heat and stasis, worsening local redness and swelling, and hindering rapid swelling reduction. Second, while many modern preparations are convenient to use, their ingredients are relatively simple, focusing only on temporary pain relief or physical cooling. They lack the comprehensive treatment approach of traditional Chinese medicine, which emphasizes activating blood circulation, removing blood stasis, cooling the blood, detoxifying, and relaxing muscles and tendons. This results in uncertain efficacy, slow swelling reduction, and a tendency to leave sequelae such as chronic pain or limited joint mobility. Third, some plaster bases have poor breathability, easily causing adverse reactions such as skin allergies and itching, leading to low patient compliance. Fourth, there is a lack of a traditional Chinese medicine topical plaster specifically designed for the characteristics of redness, swelling, heat, and pain in the acute phase of a new injury, capable of simultaneously cooling the blood and reducing swelling while activating blood circulation and removing blood stasis, and which is simple to prepare, convenient to use, and highly safe.

[0004] Therefore, there is an urgent need in this field to provide a cooling and swelling-reducing ointment with scientifically formulated components, reasonable compatibility, rapid onset of action, significant anti-swelling and analgesic effects, minimal skin irritation, and specifically for treating redness, swelling, heat, and pain caused by acute sprains, as well as its preparation method. Summary of the Invention

[0005] The purpose of this invention is to provide a cooling and swelling-reducing ointment for treating sprains and its preparation method, so as to solve the problems existing in the prior art.

[0006] To achieve the above objectives, the present invention provides the following solution: This invention provides a cooling and swelling-reducing ointment for treating sprains, made from the following raw materials in parts by weight: 3-8 parts of Wulingzhi, 0.5-3 parts of Tubiechong, 0.5-3 parts of Sanqi powder, 0.5-3 parts of Taoren, 0.5-3 parts of Honghua, 0.5-3 parts of Ruxiang, 0.5-3 parts of Moyao, 0.5-3 parts of Shanzhizi, 0.5-3 parts of Dahuang, and 0.5-3 parts of Hehuanpi.

[0007] Preferably, it is made from the following raw materials in parts by weight: 5 parts of Wulingzhi, 1 part of Tubiechong, 1 part of Sanqi powder, 1 part of Taoren, 1 part of Honghua, 1 part of Ruxiang, 1 part of Moyao, 1 part of Shanzhizi, 1 part of Dahuang, and 1 part of Hehuanpi.

[0008] Preferably, the cooling and swelling-reducing ointment further comprises pharmaceutically acceptable external excipients, which are a mixture of wild chrysanthemum juice and honey, or a mixture of magnesium sulfate solution and petrolatum.

[0009] Preferably, the weight ratio of wild chrysanthemum juice to honey is 10-30:1; the mass fraction of magnesium sulfate solution is 20%-33%, and the weight ratio of magnesium sulfate solution to petroleum jelly is 1:1-3.

[0010] Preferably, the dosage form of the cooling and swelling-reducing ointment is an ointment, cream, or gel.

[0011] This invention also provides a method for preparing a cooling and swelling-reducing ointment for treating sprains, comprising the following steps: Step A: Weigh out the following ingredients according to the specified ratio: Wulingzhi, Tubiechong, Sanqi powder, Taoren, Honghua, Ruxiang, Moyao, Shanzhizi, Dahuang, and Hehuanpi. Mix them together, pulverize them, and sift them to obtain the mixed medicinal powder. Step B: Prepare wild chrysanthemum juice by mixing wild chrysanthemum juice with honey in a certain proportion to obtain a paste base; Step C: Mix the mixed powder obtained in Step A with the ointment base obtained in Step B in a certain proportion and stir evenly to obtain the cooling and swelling-reducing ointment.

[0012] Preferably, the sieve mesh size in step A is 100-200 mesh; the method for preparing wild chrysanthemum juice in step B is as follows: take wild chrysanthemum, add water and decoct 1-3 times, each time adding water 6-12 times the weight of wild chrysanthemum, decoct for 0.5-2 hours each time, combine the decoctions, filter, and obtain the juice.

[0013] Preferably, the weight ratio of the mixed powder to the paste base in step C is 1:0.5 to 2.

[0014] The present invention also provides the application of a cooling and swelling-reducing ointment for treating sprains in the preparation of a medicine for treating local redness, swelling, heat and pain caused by acute sprains and bruises.

[0015] Preferably, the acute sprains and traumatic injuries are new injuries within one week after the injury, and their clinical manifestations include one or more of local swelling, pain, skin flushing, and elevated skin temperature.

[0016] The present invention has achieved the following beneficial technical effects compared with the prior art: A cooling and detumescence plaster for treating sprains and its preparation method provided by the present invention. This cooling and detumescence plaster has the effects of cooling blood, detumescence and relieving pain, promoting blood circulation to remove stasis, and relaxing tendons and dispersing nodules. Through the synergistic effect of multiple traditional Chinese medicines such as Trogopterus dung, Eupolyphaga seu Steleophaga, Notoginseng powder, Prunus persica, Carthamus tinctorius, Olibanum, Myrrha, Gardenia jasminoides, Rheum palmatum, Albizia julibrissin, etc. in specific weight ratios, the present invention realizes the rapid subsidence of redness, swelling, heat and pain and pain relief in the new injury stage of acute soft tissue injury. Among them, Trogopterus dung is used as the monarch drug to promote blood circulation to remove stasis and relieve pain; Eupolyphaga seu Steleophaga, Prunus persica, and Carthamus tinctorius are used as ministerial drugs to enhance the power of promoting blood circulation to remove stasis, detumescence and relieving pain; Olibanum and Myrrha are used as adjuvant drugs to dredge meridians and relieve pain; Rheum palmatum, Gardenia jasminoides, and Albizia julibrissin are used as messenger drugs to clear heat and cool blood, detoxify and remove stasis; and wild chrysanthemum juice and honey are used as a blending matrix, which not only clears heat and detoxifies, guides the drug into the collaterals, but also tonifies qi and nourishes the middle, moistens dryness and detoxifies, comprehensively enhancing the drug efficacy. The present invention adopts a process of separately treating the powdery drug and the liquid matrix and then mixing them, which maximally retains the active ingredients of the drug. The prepared cooling and detumescence plaster has a uniform texture, good spreadability, is easy to absorb, and the preparation method is simple, suitable for industrial production. After more than 40 years of clinical application verification, this product is applied to the damaged local area for those with traumatic injuries, stasis swelling and pain, and difficult-to-eliminate cyanotic ecchymosis, and has a rapid effect of detumescence and pain relief, with satisfactory curative effects, and no obvious toxic and side effects are found. Especially for the stage of redness, swelling, heat and pain within one week of the new injury, this product combines cooling blood and removing stasis, balances cold and heat, can quickly relieve the acute symptoms, and will not leave the drawback of cold coagulation, being superior to existing similar products. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required to be used in the embodiments. Obviously, the following described drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0018] Figure 1 It is a flowchart of the preparation method of the cooling and detumescence plaster for treating sprains provided by the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] The purpose of this invention is to provide a cooling and swelling-reducing ointment for treating sprains and its preparation method, so as to solve the problems existing in the prior art.

[0021] To make the above-mentioned objects, features, and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. Experimental methods in the embodiments of the present invention that do not specify specific conditions are generally carried out under conventional conditions or according to the conditions recommended by the raw material manufacturer. Reagents or instruments used that do not specify the manufacturer are all commercially available conventional products.

[0022] Example 1: Preparation of Cooling and Swelling-Reducing Ointment This embodiment provides a cooling and swelling-reducing ointment for treating sprains, the raw materials of which are formulated in the following proportions by weight: 5 parts of Wulingzhi, 1 part of Tubiechong, 1 part of Sanqi powder, 1 part of Taoren, 1 part of Honghua, 1 part of Ruxiang, 1 part of Moyao, 1 part of Shanzhizi, 1 part of Dahuang, and 1 part of Hehuanpi.

[0023] The preparation method is as follows: First, weigh each herb according to the above proportions, clean and dry them separately, mix them evenly, pulverize them into a fine powder, and pass them through a 150-mesh sieve to obtain a mixed powder for later use. Second, prepare the ointment base: take 500 grams of dried wild chrysanthemum, add 8 times the amount of water, decoct for 1.5 hours, and filter to obtain the juice; add 6 times the amount of water to the dregs and decoct for 1 hour, combine the two decoctions, filter, and obtain wild chrysanthemum juice. Mix the wild chrysanthemum juice and honey evenly at a weight ratio of 20:1 to obtain the ointment base. Finally, place the above mixed powder and ointment base in a mixer at a weight ratio of 1:1, and mix thoroughly at room temperature to form a homogeneous ointment, thus obtaining the cooling and swelling-reducing ointment.

[0024] Example 2: Preparation of Cooling and Swelling-Reducing Ointment This embodiment provides a cooling and swelling-reducing ointment for treating sprains, the raw materials of which are formulated in the following proportions by weight: 8 parts of Wulingzhi, 3 parts of Tubiechong, 3 parts of Sanqi powder, 3 parts of Taoren, 3 parts of Honghua, 0.5 parts of Ruxiang, 0.5 parts of Moyao, 0.5 parts of Shanzhizi, 0.5 parts of Dahuang, and 0.5 parts of Hehuanpi.

[0025] The preparation method is as follows: Grind the above-mentioned medicinal materials into a fine powder and pass through a 100-mesh sieve. Separately, take wild chrysanthemum, add water and decoct twice, adding 10 times the amount of water for the first time and 8 times the amount of water for the second time, each time for 1 hour. Combine the decoctions, filter, and obtain wild chrysanthemum juice. Mix the wild chrysanthemum juice with honey at a weight ratio of 10:1 to use as the paste base. Mix the mixed medicinal powder with the paste base at a weight ratio of 1:1.5 and stir well to obtain the final product.

[0026] Example 3: Preparation of Cooling and Swelling-Reducing Ointment This embodiment provides a cooling and swelling-reducing ointment for treating sprains, the raw materials of which are formulated in the following proportions by weight: 3 parts of Wulingzhi, 0.5 parts of Tubiechong, 0.5 parts of Sanqi powder, 0.5 parts of Taoren, 0.5 parts of Honghua, 3 parts of Ruxiang, 3 parts of Moyao, 3 parts of Shanzhizi, 3 parts of Dahuang, and 3 parts of Hehuanpi.

[0027] The preparation method is as follows: Grind the above-mentioned medicinal materials into a fine powder and pass it through a 200-mesh sieve. In the preparation of the paste base, the weight ratio of wild chrysanthemum juice to honey is 30:1. Mix the mixed medicinal powder with the paste base at a weight ratio of 1:0.5 and stir until homogeneous.

[0028] Example 4: Preparation of Cooling and Swelling-Reducing Ointment This embodiment provides a cooling and swelling-reducing ointment for treating sprains, with the same raw material weight ratio as in Example 1. The difference lies in that the ointment base in this embodiment is a mixture of magnesium sulfate solution and petrolatum. Specifically, a 25% magnesium sulfate solution is prepared, and this magnesium sulfate solution is mixed evenly with petrolatum at a weight ratio of 1:2 to obtain a substitute base. Then, the mixed powder obtained in Example 1 is mixed with the substitute base at a weight ratio of 1:1 and stirred evenly to obtain the cooling and swelling-reducing ointment. This embodiment is suitable for patients allergic to honey.

[0029] Comparative Example 1: Cooling and Swelling-Reducing Ointment Deficient in Five-Tonifying- This comparative example provides a cooling and swelling-reducing ointment, the raw materials of which are formulated in the following proportions by weight: 1 part ground beetle, 1 part Panax notoginseng powder, 1 part peach kernel, 1 part safflower, 1 part frankincense, 1 part myrrh, 1 part gardenia, 1 part rhubarb, and 1 part Albizia bark. That is, compared to Example 1, it lacks the principal ingredient, Trogopterus xanthipes. The preparation method is the same as in Example 1.

[0030] Comparative Example 2: Cooling and Swelling-Reducing Ointment Lacking Rhubarb and Gardenia This comparative example provides a cooling and swelling-reducing ointment, the raw materials of which are formulated in the following weight proportions: 5 parts of Trogopterus xanthipes, 1 part of Eupolyphaga sinensis, 1 part of Panax notoginseng powder, 1 part of peach kernel, 1 part of safflower, 1 part of frankincense, 1 part of myrrh, and 1 part of Albizia julibrissin bark. Compared to Example 1, it lacks rhubarb and gardenia, which are known for their heat-clearing and blood-cooling properties. The preparation method is the same as in Example 1.

[0031] Comparative Example 3: A commercially available blood-activating and pain-relieving plaster was used. This comparative example uses a commercially available brand of blood-activating and pain-relieving plaster as a control. The main ingredients of this plaster are Panax notoginseng, Angelica sinensis, frankincense, myrrh, borneol, etc., which have the effects of activating blood circulation, relieving pain, relaxing muscles and tendons, and promoting blood circulation. It is suitable for sprains, bruises, swelling and pain.

[0032] Pharmacodynamic trials and efficacy evaluation To verify the therapeutic effect of the cooling and swelling-reducing ointment of the present invention on redness, swelling, heat and pain caused by acute sprains, a classic animal model was used for the experiment, and the results were compared and evaluated with Examples 1 and 4, and Comparative Examples 1, 2 and 3.

[0033] Experimental Methods: One hundred healthy adult male SD rats, weighing 200±20g, were randomly divided into 5 groups of 20 rats each: Example 1, Example 4, Comparative Example 1, Comparative Example 2, and Comparative Example 3. An acute soft tissue injury model was established in rats according to literature methods: Impact points were marked on the hind legs of the rats. A self-made impact device was used to drop a 200g weight from a height of 30cm five times consecutively, causing local swelling, ecchymosis, and tenderness, thus creating an acute injury model. Thirty minutes after successful model establishment, each group received topical treatment with the corresponding medication. For Example 1, Example 4, Comparative Example 1, and Comparative Example 2, an appropriate amount of ointment was evenly applied to gauze and applied to the injured area, changed once daily. For Comparative Example 3, a commercially available blood-activating and pain-relieving plaster was applied, changed once daily. Treatment was continued for 3 days. The circumference of the lower leg at the injury site of rats in each group was measured before modeling, 2 hours after modeling, and 24, 48, and 72 hours after treatment. The swelling rate was calculated as follows: Swelling rate = (Circumference after treatment - Circumference before modeling) / Circumference before modeling × 100%. The reduction of redness and swelling at the injury site, tenderness response (scored by the degree of limb withdrawal after stimulation: 0 points - no response, 1 point - mild withdrawal, 2 points - moderate withdrawal, 3 points - severe withdrawal), and skin irritation response were also observed and recorded in each group of rats. The results are shown in Tables 1 and 2.

[0034] Table 1 Comparison of swelling rates at the injury sites in rats of different groups (x±s, n=20) ; Note: Compared with Comparative Example 3, *P<0.05; compared with Comparative Example 1 and Comparative Example 2, #P<0.05.

[0035] Table 2. Tenderness scores and skin irritation in rats of each group after 72 hours of treatment. ; Note: Compared with Comparative Example 3, *P<0.05; compared with Comparative Example 1 and Comparative Example 2, #P<0.05.

[0036] The experimental results showed that the swelling rate of the rat injury sites treated with the cooling and swelling-reducing ointments of Examples 1 and 4 of this invention was significantly lower than that of Comparative Examples 1, 2, and 3 after 24, 48, and 72 hours of treatment, with statistically significant differences (P<0.05). Simultaneously, the tenderness scores of Examples 1 and 4 were also significantly lower than those of the comparative examples, indicating superior analgesic effects. Comparative Example 1, lacking the principal ingredient Wulingzhi, and Comparative Example 2, lacking the heat-clearing and blood-cooling herbs Dahuang and Shanzhizi, showed significantly reduced swelling-reducing and analgesic effects, demonstrating the indispensable synergistic effect of the principal, assistant, adjuvant, and guiding herbs in the formula of this invention. Furthermore, none of the examples of this invention caused skin irritation, while Comparative Example 3 showed 3 cases of mild itching, indicating better safety of this invention. Example 4, using magnesium sulfate and petrolatum as substitutes for the matrix, also achieved good results, providing an alternative for patients with special allergies.

[0037] Application of typical clinical cases The cooling and swelling-reducing ointment prepared in Example 1 of this invention was used to treat 50 patients with acute ankle sprains (within 48 hours of onset, significant local redness, swelling, heat, and pain). Method of use: Apply an appropriate amount of the cooling and swelling-reducing ointment evenly onto gauze, apply to the affected area, change once daily, and treat for 3-7 days. Results: Of the 50 patients, 42 were cured (swelling and pain completely disappeared, joint movement was free), 7 showed significant improvement (swelling and pain basically disappeared, slight discomfort during activity), 1 was effective (swelling and pain significantly reduced), and 0 were ineffective, with a total effective rate of 100%. More than 80% of the patients experienced significant pain reduction within 24 hours of application, and swelling began to subside significantly within 48 hours. No skin allergies or other adverse reactions were observed during the treatment. Typical case: Patient Li, male, 25 years old, sprained his right ankle 4 hours after exercise, with severe local swelling, redness, increased skin temperature, and intense pain, making it impossible to stand. When the cooling and swelling-reducing ointment of this invention was applied externally, the swelling was reduced by about 50% and the pain was significantly reduced after 24 hours, allowing the patient to walk with support. After 3 days of continuous use, the swelling was reduced by about 90% and the pain was basically gone, allowing the patient to walk freely. Continued use for 2 more days was used to consolidate the treatment and the patient recovered completely.

[0038] The above examples, comparative examples, and clinical cases fully demonstrate that the cooling and swelling-reducing ointment provided by the present invention has excellent effects in rapidly reducing swelling, significantly relieving pain, promoting blood circulation and removing blood stasis, and cooling blood and clearing heat for redness, swelling and pain caused by acute sprains and bruises. Moreover, the preparation method is simple, safe and non-irritating, and has extremely high clinical application value and market promotion prospects.

[0039] This invention has illustrated its principles and implementation methods using specific examples. The descriptions of these embodiments are merely illustrative of the method and its core ideas; furthermore, those skilled in the art will recognize that modifications may be made to the specific implementation methods and application scope based on the principles of this invention. Therefore, the content of this specification should not be construed as limiting the invention.

Claims

1. A cooling anti-inflammatory plaster for treating sprains, characterized in that, It is made from the following raw materials in parts by weight: 3-8 parts of Wulingzhi, 0.5-3 parts of Tubiechong, 0.5-3 parts of Sanqi powder, 0.5-3 parts of Taoren, 0.5-3 parts of Honghua, 0.5-3 parts of Ruxiang, 0.5-3 parts of Moyao, 0.5-3 parts of Shanzhizi, 0.5-3 parts of Dahuang, and 0.5-3 parts of Hehuanpi.

2. The cooling anti-inflammatory plaster for treating sprain according to claim 1, wherein It is made from the following raw materials in parts by weight: 5 parts of Wulingzhi, 1 part of Tubiechong, 1 part of Sanqi powder, 1 part of Taoren, 1 part of Honghua, 1 part of Ruxiang, 1 part of Moyao, 1 part of Shanzhizi, 1 part of Dahuang, and 1 part of Hehuanpi.

3. The cooling and swelling ointment for treating sprain according to claim 1 or 2, characterized in that, The cooling and swelling-reducing ointment also contains pharmaceutically acceptable external excipients, which are either a mixture of wild chrysanthemum juice and honey, or a mixture of magnesium sulfate solution and petrolatum.

4. The cooling anti-inflammatory plaster for treating sprain according to claim 3, wherein The weight ratio of wild chrysanthemum juice to honey is 10-30:1; the mass fraction of magnesium sulfate solution is 20%-33%, and the weight ratio of magnesium sulfate solution to petroleum jelly is 1:1-3.

5. The cooling anti-inflammatory plaster for treating sprain according to claim 1, wherein The dosage form of the cooling and swelling-reducing ointment is an ointment, cream, or gel.

6. A method of preparing the cooling and swelling ointment for treating sprain according to any one of claims 1 to 5, characterized in that, Includes the following steps: Step A: Weigh out the following ingredients according to the specified ratio: Wulingzhi, Tubiechong, Sanqi powder, Taoren, Honghua, Ruxiang, Moyao, Shanzhizi, Dahuang, and Hehuanpi. Mix them together, pulverize them, and sift them to obtain the mixed medicinal powder. Step B: Prepare wild chrysanthemum juice by mixing wild chrysanthemum juice with honey in a certain proportion to obtain a paste base; Step C: Mix the mixed powder obtained in Step A with the ointment base obtained in Step B in a certain proportion and stir evenly to obtain the cooling and swelling-reducing ointment.

7. The preparation method of the cooling and swelling-reducing plaster for treating sprain according to claim 6, characterized in that, The sieve used for sieving in step A has a mesh size of 100-200. The method for preparing wild chrysanthemum juice in step B is as follows: take wild chrysanthemum, add water and decoct 1-3 times, each time adding water at a volume of 6-12 times the weight of wild chrysanthemum, decoct for 0.5-2 hours each time, combine the decoctions, filter, and the juice is obtained.

8. The method for preparing the cooling and swelling-reducing ointment for treating sprains according to claim 6, characterized in that, The weight ratio of the mixed powder to the paste base in step C is 1:0.5 to 2.

9. The use of the cooling and swelling-reducing ointment for treating sprains according to any one of claims 1 to 5 in the preparation of a medicament for treating local redness, swelling, heat and pain caused by acute sprains and bruises.

10. The application according to claim 9, characterized in that, Acute sprains and bruises are new injuries within one week of the initial injury, and their clinical manifestations include one or more of the following: local swelling, pain, skin redness, and elevated skin temperature.

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