A herbal composite bacteriostatic external preparation containing salvia miltiorrhiza and a preparation method thereof

Abstract

This invention discloses a herbal compound antibacterial topical preparation containing Sedum aizoon and its preparation method, belonging to the field of traditional Chinese medicine preparation technology. It includes the following raw materials: Sedum aizoon extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Aloe vera gel, glycerin, grape seed oil extract, vitamin E, Phellodendron amurense extract, Kochia scoparia extract, peppermint extract, silver ions, and purified water. This invention uses Sedum aizoon as the core antibacterial ingredient, combined with multiple herbs and silver ions, to synergistically enhance the long-lasting antibacterial ability against Staphylococcus aureus, Escherichia coli, and Candida albicans. The formula is hormone-free, artificial colorant-free, and free of irritating alcohols, suitable for daily antibacterial care in various scenarios such as mosquito bites, itchy skin, superficial skin, and intimate areas.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a herbal compound antibacterial external preparation containing Sedum aizoon and its preparation method. Background Technology

[0002] In recent years, topical antibacterial skin products have been widely used for relieving itching from mosquito bites, caring for itchy skin, inhibiting bacteria on superficial wounds, and daily care of intimate areas. However, existing product formulations, manufacturing processes, and product performance all have many shortcomings, and there are significant technological gaps in the industry, as detailed below:

[0003] (1) The antibacterial system is highly irritating and the proportion of herbal active ingredients is extremely low: Most existing antibacterial products rely on high doses of single chemical antibacterial agents to achieve the bactericidal effect. The amount of herbal extracts added is very small, which only plays a weak auxiliary soothing role and has poor effects on relieving itching and repairing skin discomfort. At the same time, in order to extend the shelf life, high concentrations of alcohol and irritating chemical preservatives are generally added. People with sensitive skin or skin with broken or reddened skin are very likely to experience adverse reactions such as burning, stinging, allergic redness after use, which limits the applicable population.

[0004] (2) Single antibacterial solutions have functional shortcomings: antibacterial products with silver ions as the core only have simple bactericidal ability and lack herbal soothing and repairing active ingredients. They can only kill pathogenic bacteria on the skin surface and cannot relieve itching and swelling caused by mosquito bites and inflammation. Moreover, the antibacterial effect of silver ions is short-lived and the long-term antibacterial ability is insufficient. The antibacterial effect lasts for a limited time after a single application, resulting in a poor user experience.

[0005] (3) Traditional high-temperature processing technology destroys the activity of herbs and greatly reduces efficacy: Most of the conventional herbal antibacterial preparations on the market use high-temperature boiling process to process herbal raw materials. The high-temperature environment will destroy the core active substances such as flavonoids and saponins in herbs, directly weakening the core antibacterial, soothing and repairing effects of the product; the activity of the finished product is rapidly lost after long-term storage, and the antibacterial effect is significantly reduced.

[0006] (4) Poor product formulation versatility and insufficient system stability: Existing antibacterial related product formulations are highly targeted and can only be adapted to single dosage forms such as sprays and creams. They cannot be flexibly modified into various external products such as rollerball applicators, body care washes, and repair gels, resulting in weak industrial adaptability. At the same time, most herbal compound formulations have poor water-oil compatibility, and long-term storage can easily lead to problems such as layering, turbidity, and precipitation of impurities, resulting in poor product shelf-life stability.

[0007] Therefore, providing a mild, highly effective, and versatile antibacterial topical preparation and its preparation method is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0008] To address the above problems, this invention provides a herbal compound antibacterial topical preparation containing Sedum aizoon and its preparation method.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] A herbal compound antibacterial topical preparation containing Sedum aizoon comprises the following raw materials: Sedum aizoon extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Aloe vera gel, glycerin, grape seed oil extract, vitamin E, Phellodendron amurense extract, Kochia scoparia extract, peppermint extract, silver ions, and purified water.

[0011] This invention is a compound herbal system with Sedum aizoon as the core active ingredient, which synergistically enhances the long-lasting antibacterial ability against Staphylococcus aureus, Escherichia coli, and Candida albicans. The formula is free of hormones, artificial colors, and irritating alcohols, and is suitable for daily antibacterial care in various scenarios such as mosquito bites, itchy skin, superficial skin, and intimate areas.

[0012] Preferably, the raw materials include the following percentages by weight: 2.0-4.2% Sedum aizoon extract, 0.7-1.3% Artemisia argyi extract, 0.8-1.4% Lonicera japonica extract, 0.5-1.1% Witch hazel extract, 3.0-5.0% Aloe vera gel, 4.0-6.0% Glycerin, 0.4-0.8% Grape seed oil extract, 0.15-0.25% Vitamin E, 0.4-1.0% Phellodendron chinense extract, 0.3-0.7% Kochia scoparia extract, 0.2-0.4% Mentha haplocalyx extract, 5.8-8.5 mg / kg Silver ions, with the balance being purified water.

[0013] Preferably, the raw materials include the following percentages by weight: 3.2% Sedum aizoon extract, 1.0% Artemisia argyi extract, 1.1% Lonicera japonica extract, 0.8% Witch hazel extract, 4.0% Aloe vera gel, 5.0% Glycerin, 0.6% Grape seed oil extract, 0.2% Vitamin E, 0.7% Phellodendron chinense extract, 0.5% Kochia scoparia extract, 0.3% Mentha haplocalyx extract, 6.5 mg / kg silver ions, and purified water to 100%.

[0014] Preferably, the topical preparation includes rollerball applicators, sprays, gels, creams, and lotions.

[0015] The preparation method of the above-described herbal compound antibacterial topical preparation containing Sedum aizoon specifically includes the following steps:

[0016] (1) Weigh the raw materials according to the stated mass percentage and set aside;

[0017] (2) Heat the purified water to 40-50℃, add glycerin and aloe vera gel, and stir until completely dissolved to obtain an aqueous phase base;

[0018] (3) After adding Sedum aizoon extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Phellodendron amurense extract, Kochia scoparia extract and peppermint extract to the aqueous substrate, stir evenly to obtain the herbal compound system.

[0019] (4) Grape seed oil and vitamin E are added to the herbal compound system and homogenized to obtain an oil mixture system;

[0020] (5) After adding silver ion aqueous solution to the oil mixture and stirring evenly, a herbal compound antibacterial external preparation containing Sedum sarmentosum is obtained.

[0021] The preparation method of this invention adopts a low-temperature and mild preparation process, which fully preserves the active ingredients of the herbs. The finished product system is stable and does not separate into layers. The original solution can be processed into a variety of external dosage forms such as rollerball applicator, antibacterial spray, repair gel, antibacterial cream, and body care wash, and has versatility.

[0022] Preferably, the stirring speed in step (2) is 60-100 rpm and the stirring time is 10-15 min.

[0023] Preferably, the stirring speed in step (3) is 200-300 rpm and the stirring time is 20-30 min;

[0024] The extracts of Sedum aizoon, Artemisia argyi, Lonicera japonica, Witch hazel, Phellodendron amurense, Kochia scoparia, and Mentha haplocalyx were sieved through a 100-mesh sieve to remove impurities before being added.

[0025] Preferably, the aqueous substrate in step (3) is cooled to below 30°C before other herbal extracts are added.

[0026] Preferably, the stirring speed in step (4) is 3000-5000 rpm and the stirring time is 5-10 min.

[0027] Preferably, the stirring speed in step (5) is 150-200 rpm and the stirring time is 5-15 min.

[0028] Preferably, after stirring evenly in step (5), the process also includes standing to defoam and filtration through a filter membrane.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] (1) Synergistic antibacterial advantage: This invention uses Panax notoginseng as the core antibacterial raw material, combined with multiple herbal compound, which increases the antibacterial rate by more than 20% compared with single silver ion or single herbal formula. After 5 minutes of action, the antibacterial rate of the three target bacteria is ≥99.96%;

[0031] (2) Mild and low irritation: This invention is free of alcohol and irritating chemical preservatives. Herbal repair ingredients can relieve itching and redness caused by mosquito bites. It does not cause obvious stinging when used on broken skin. It has been determined to be non-irritating by skin irritation test.

[0032] (3) The activity is fully preserved: The core mixing step of this invention is controlled at a low temperature below 30°C to avoid high temperature damage to the active substances of herbal flavonoids and saponins. The antibacterial and soothing effects of the product do not diminish after 12 months of storage.

[0033] (4) The system has strong versatility and stability: The present invention uses a moisturizing system of glycerin and aloe vera gel combined with trace amounts of vitamin E for anti-oxidation. The original solution does not separate, become cloudy, or have an odor when stored at room temperature and sealed for 12 months. The original solution can be further processed into various antibacterial products such as rollerballs, sprays, gels, creams, and care washes. The core efficacy of the formula is not affected by changes in dosage form.

[0034] (5) Full coverage of application scenarios: The formulation of this invention is suitable for daily skin antibacterial care, outdoor mosquito bite relief, private body surface antibacterial, temporary care for skin itching, and superficial wound antibacterial repair and other scenarios.

[0035] (6) Strong adaptability to production: The preparation process parameters of this invention are easy to control, the equipment is universal, no high temperature and high pressure equipment is required, and it can be flexibly packaged after filtration, making it suitable for large-scale production of various external antibacterial preparations. Attached Figure Description

[0036] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. The drawings in this description are merely embodiments of the present invention.

[0037] Figure 1 This is a process flow diagram of an embodiment of the present invention;

[0038] Figure 2 This is a conclusion diagram from the product testing report of Embodiment 1 of the present invention;

[0039] Figure 3 This is a conclusion diagram from the product testing report of Embodiment 1 of the present invention;

[0040] Figure 4 This is a conclusion diagram from the product testing report of Embodiment 2 of the present invention;

[0041] Figure 5 This is a conclusion diagram from the product testing report of Embodiment 2 of the present invention. Detailed Implementation

[0042] Embodiments of the present invention are described below, examples of which are shown in the accompanying drawings. The embodiments described with reference to the drawings are exemplary and intended to explain the present invention, but are not to be construed as limiting the present invention.

[0043] Example 1

[0044] like Figure 1 This invention provides a method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon, specifically including the following steps:

[0045] (1) Weigh the raw materials according to the following mass percentages: 2.0% of Sedum aizoon extract, 0.7% of Artemisia argyi extract, 0.8% of Lonicera japonica extract, 0.5% of Witch hazel extract, 3.0% of Aloe vera gel, 4.0% of Glycerin, 0.4% of Grape seed oil extract, 0.15% of Vitamin E, 0.4% of Phellodendron chinense extract, 0.3% of Kochia scoparia extract, 0.2% of Mentha haplocalyx extract, 7.2 mg / kg of Silver ions, with the remainder being purified water. All herbal extracts are passed through a 100-mesh sieve to remove impurities.

[0046] (2) Heat the purified water to 45°C, add glycerin and aloe vera gel, stir at low speed of 60 rpm for 12 min until completely dissolved, and obtain an aqueous phase base;

[0047] (3) After the aqueous substrate cools down to below 30°C, add the following extracts in sequence: Panax notoginseng extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Phellodendron chinense extract, Kochia scoparia extract and Mentha haplocalyx extract. Stir at 200 rpm for 25 min at a constant temperature to obtain the herbal compound system.

[0048] (4) Add grape seed oil and vitamin E to the herbal compound system, and homogenize at 3000 rpm for 8 minutes to achieve water-oil mixing and obtain an oil-oil mixture system.

[0049] (5) After adding silver ion aqueous solution to the oil mixture, stir at 150 rpm for 10 min to mix evenly, then let stand at room temperature for 30 min to eliminate air bubbles, and filter and dispense the herbal compound antibacterial external preparation containing Sedum sarmentosum using a 0.22 μm sterile filter membrane.

[0050] The prepared topical formulation was then processed into an antibacterial solution and sent for testing (Standard Biotech Pharmaceutical Technology (Qingdao) Co., Ltd.). The relevant conclusions are as follows: Figure 2-3 The Sedum aizoon herbal antibacterial liquid prepared by this invention meets all current national standards for disinfection products in terms of physicochemical, microbiological, toxicological, stability, and antibacterial efficacy indicators. The formula components are scientifically matched, and the low-temperature preparation process can completely preserve the herbal antibacterial activity. It has multiple advantages such as strong antibacterial effect, mild and low irritation, long-lasting stability, and high safety. It can be mass-produced and processed into various external dosage forms such as spray, gel, cream, and lotion, solving the industry pain points of existing antibacterial products on the market, such as high irritation, short antibacterial time, poor stability, and easy loss of activity.

[0051] Example 2

[0052] like Figure 1 This invention provides a method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon, specifically including the following steps:

[0053] (1) Weigh the raw materials according to the following mass percentages: 4.2% of Sedum aizoon extract, 1.3% of Artemisia argyi extract, 1.4% of Lonicera japonica extract, 1.1% of Witch hazel extract, 5.0% of Aloe vera gel, 6.0% of Glycerin, 0.8% of Grape seed oil extract, 0.25% of Vitamin E, 1.0% of Phellodendron chinense extract, 0.7% of Kochia scoparia extract, 0.4% of Mentha haplocalyx extract, 7.4 mg / kg of Silver ions, with the remainder being purified water. All herbal extracts were passed through a 100-mesh sieve to remove impurities.

[0054] (2) Heat the purified water to 45°C, add glycerin and aloe vera gel, stir at 100 rpm for 12 min until completely dissolved, and obtain an aqueous phase substrate;

[0055] (3) After the aqueous substrate cools down to below 30°C, add the following extracts in sequence: Panax notoginseng extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Phellodendron chinense extract, Kochia scoparia extract and Mentha haplocalyx extract. Stir at 300 rpm for 25 min at a constant temperature to obtain the herbal compound system.

[0056] (4) Add grape seed oil and vitamin E to the herbal compound system, and homogenize at high speed of 5000 rpm for 8 minutes to achieve water-oil mixing and obtain oil-oil mixture system;

[0057] (5) After adding silver ion aqueous solution to the oil mixture, stir at 200 rpm for 10 min to mix evenly, then let stand at room temperature for 30 min to eliminate air bubbles, and filter and dispense the herbal compound antibacterial external preparation containing Sedum sarmentosum using a 0.22 μm sterile filter membrane.

[0058] The prepared topical formulation was then formulated into an antibacterial roll-on and sent for testing (Standard Biotech Pharmaceutical Technology (Qingdao) Co., Ltd.). The relevant conclusions are as follows: Figure 4-5 The Sedum aizoon herbal antibacterial liquid prepared by this invention meets all current national standards for disinfection products in terms of physicochemical, microbiological, toxicological, stability, and antibacterial efficacy indicators. The formula components are scientifically matched, and the low-temperature preparation process can completely preserve the herbal antibacterial activity. It has multiple advantages such as strong antibacterial effect, mild and low irritation, long-lasting stability, and high safety. It can be mass-produced and processed into various external dosage forms such as spray, gel, cream, and lotion, solving the industry pain points of existing antibacterial products on the market, such as high irritation, short antibacterial time, poor stability, and easy loss of activity.

[0059] Example 3

[0060] like Figure 1This invention provides a method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon, specifically including the following steps:

[0061] (1) Weigh the raw materials according to the following mass percentages: 3.2% Sedum aizoon extract, 1.0% Artemisia argyi extract, 1.1% Lonicera japonica extract, 0.8% Witch hazel extract, 4.0% Aloe vera gel, 5.0% Glycerin, 0.6% Grape seed oil extract, 0.2% Vitamin E, 0.7% Phellodendron chinense extract, 0.5% Kochia scoparia extract, 0.3% Mentha haplocalyx extract, 6.5 mg / kg silver ions, and make up to 100% with purified water. Set aside. All herbal extracts are passed through a 100-mesh sieve to remove impurities.

[0062] (2) Heat the purified water to 45°C, add glycerin and aloe vera gel, stir at low speed of 80 rpm for 10 min until completely dissolved, and obtain an aqueous phase base;

[0063] (3) After the aqueous substrate cools down to below 30°C, add the following extracts in sequence: Panax notoginseng extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Phellodendron amurense extract, Kochia scoparia extract and Mentha haplocalyx extract. Stir at 250 rpm for 20 min at a constant temperature to obtain the herbal compound system.

[0064] (4) Add grape seed oil and vitamin E to the herbal compound system, and homogenize at 4000 rpm for 10 min to achieve water-oil mixing and obtain oil-oil mixture system;

[0065] (5) After adding silver ion aqueous solution to the oil mixture, stir at 200 rpm for 15 min to mix evenly, then let stand at room temperature for 30 min to eliminate air bubbles, and filter and dispense the herbal compound antibacterial external preparation containing Sedum aizoon using a 0.22 μm sterile filter membrane.

[0066] Comparative Example 1

[0067] The difference from Example 3 is that the raw materials do not include Artemisia argyi extract, honeysuckle extract, witch hazel extract, Phellodendron amurense extract, Kochia scoparia extract and peppermint extract, and are replaced by water, while the rest are the same as in Example 3.

[0068] Comparative Example 2

[0069] The difference from Example 3 is that the raw materials do not include Sedum aizoon extract, and water is used instead; otherwise, it is the same as Example 3.

[0070] Comparative Example 3

[0071] The difference from Example 3 is that the raw materials do not include silver ions and are replaced by water; otherwise, they are the same as in Example 3.

[0072] Comparative Example 4

[0073] The difference from Example 3 is that the raw materials do not include Sedum aizoon extract and silver ions, and are replaced by water; otherwise, they are the same as in Example 3.

[0074] Comparative Example 5

[0075] The difference from Example 3 is that the raw materials do not include silver ions, artemisia extract, honeysuckle extract, witch hazel extract, phellodendron extract, kochia extract and peppermint extract, and are replaced by water, while the rest are the same as in Example 3.

[0076] Comparative Example 6

[0077] The difference from Example 3 is that the raw materials do not include Sedum aizoon extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Phellodendron amurense extract, Kochia scoparia extract and Mentha haplocalyx extract, but are replaced with water, while the rest are the same as in Example 3.

[0078] Antibacterial rate experiments were conducted on the products from Example 3 and Comparative Examples 1-6.

[0079] Reference standards: GB 15979-2024 "Hygienic Standard for Disposable Sanitary Products", QB / T 2738-2023 "Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products", and Disinfection Technical Specification (2002 Edition) Suspension Quantitative Antibacterial Test Method;

[0080] Test strains: Staphylococcus aureus, Escherichia coli, Candida albicans;

[0081] Test conditions: temperature 19-22℃, relative humidity 48-52%, contact time 5min;

[0082] The relevant data is shown in Table 1:

[0083] Table 1. Conclusions on the antibacterial rate of products from Example 3 and Comparative Examples 1-6

[0084]

[0085] As shown in the table above, Comparative Example 5 (using only Sedum aizoon) and Comparative Example 6 (using only silver ions) both showed antibacterial rates below 85% for all three strains, indicating limited antibacterial effects when using Sedum aizoon or trace amounts of silver ions alone. High-level antibacterial efficacy cannot be achieved by relying solely on a single herb or silver ions. Comparative Examples 1 and 2 showed antibacterial rates in the 95-98% range, a significant improvement compared to single-ingredient formulations, but still below the 99.9% or higher standard for potent antibacterial efficacy. This suggests a basic synergistic effect between Sedum aizoon and silver ions, but insufficient synergy when auxiliary herbs such as Artemisia argyi and Lonicera japonica are absent. Comparative Example 3, retaining all herbs but removing silver ions, showed an antibacterial rate of only 93-95%, a decrease compared to Example 3. Clearly, trace amounts of silver ions enhance bactericidal activity and shorten the onset time, making them a key antibacterial and synergistic component of the system. Comparative Example 1 showed significantly better antibacterial effects than Comparative Example 2, indicating that Sedum aizoon is the core of the entire herbal system's antibacterial activity, and its absence significantly reduces the main efficacy. Example 3, which simultaneously contains Sedum aizoon, multiple compound herbs, and trace amounts of silver ions, achieved an antibacterial rate of ≥99.96% against all three pathogenic bacteria within 5 minutes, representing an improvement of over 20% in antibacterial effect compared to any single ingredient or any formula lacking a component. The antibacterial activity of multiple herbal flavonoids and saponins complements the bactericidal mechanism of silver ions, forming a multi-level antibacterial system and achieving synergistic effects, thus verifying the technical advantages of the compound formulation of this invention.

[0086] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A herbal compound antibacterial topical preparation containing Sedum aizoon, characterized in that, It includes the following raw materials: Sedum aizoon extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Aloe vera gel, Glycerin, Grape seed oil extract, Vitamin E, Phellodendron amurense extract, Kochia scoparia extract, Peppermint extract, Silver ions, and purified water.

2. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 1, characterized in that, The product contains the following raw materials by weight percentage: Sedum aizoon extract 2.0-4.2%, Artemisia argyi extract 0.7-1.3%, Lonicera japonica extract 0.8-1.4%, Witch hazel extract 0.5-1.1%, Aloe vera gel 3.0-5.0%, Glycerin 4.0-6.0%, Grape seed oil extract 0.4-0.8%, Vitamin E 0.15-0.25%, Phellodendron amurense extract 0.4-1.0%, Kochia scoparia extract 0.3-0.7%, Mentha haplocalyx extract 0.2-0.4%, Silver ions 5.8-8.5 mg / kg, with the balance being purified water.

3. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 2, characterized in that, The product contains the following raw materials by weight percentage: Sedum aizoon extract 3.2%, Artemisia argyi extract 1.0%, Lonicera japonica extract 1.1%, Witch hazel extract 0.8%, Aloe vera gel 4.0%, Glycerin 5.0%, Grape seed oil extract 0.6%, Vitamin E 0.2%, Phellodendron amurense extract 0.7%, Kochia scoparia extract 0.5%, Mentha haplocalyx extract 0.3%, Silver ions 6.5 mg / kg, and purified water to 100%.

4. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 1, characterized in that, The topical preparations include rollerball applicators, sprays, gels, creams, and lotions.

5. A method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to any one of claims 1-4, characterized in that, Specifically, the following steps are included: (1) Weigh the raw materials according to the stated mass percentage and set aside; (2) Heat the purified water to 40-50℃, add glycerin and aloe vera gel, and stir until completely dissolved to obtain an aqueous phase base; (3) After adding Sedum aizoon extract, Artemisia argyi extract, Lonicera japonica extract, Witch hazel extract, Phellodendron amurense extract, Kochia scoparia extract and peppermint extract to the aqueous substrate, stir evenly to obtain the herbal compound system. (4) Grape seed oil and vitamin E are added to the herbal compound system and homogenized to obtain an oil mixture system; (5) After adding silver ion aqueous solution to the oil mixture and stirring evenly, a herbal compound antibacterial external preparation containing Sedum sarmentosum is obtained.

6. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 5, characterized in that, The stirring speed in step (2) is 60-100 rpm, and the stirring time is 10-15 min.

7. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 5, characterized in that, The stirring speed in step (3) is 200-300 rpm, and the stirring time is 20-30 min; The extracts of Sedum aizoon, Artemisia argyi, Lonicera japonica, Witch hazel, Phellodendron amurense, Kochia scoparia, and Mentha haplocalyx were sieved through a 100-mesh sieve to remove impurities before being added.

8. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 5, characterized in that, The stirring speed in step (4) is 3000-5000 rpm, and the stirring time is 5-10 min.

9. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 5, characterized in that, The stirring speed in step (5) is 150-200 rpm, and the stirring time is 5-15 min.

10. The method for preparing a herbal compound antibacterial topical preparation containing Sedum aizoon according to claim 5, characterized in that, After stirring evenly in step (5), the process also includes standing to defoam and filtration through a filter membrane.

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