A medicinal and edible composition and its application in regulating endocrine

Abstract

This invention discloses a food-medicine homology composition and its application in regulating endocrine function, relating to the fields of medicine, food, and health products. The composition comprises Polygonatum sibiricum, Dioscorea opposita, Coix lacryma-jobi, Cornus officinalis, Lycium barbarum, Poria cocos, Nelumbo nucifera leaf, donkey-hide gelatin, prepared licorice root, Ziziphus jujuba seed, and Citrus reticulata peel. The raw materials are combined in a specific mass ratio, and the extract is obtained after pulverization, water extraction, filtration, concentration, and drying. Animal experiments show that this composition can reduce serum T3 and T4 levels in thyroxine-induced model animals, improve symptoms such as weight loss, elevated body temperature, and decreased exercise tolerance, and downregulate serum cytokine levels such as IL-6, TNF-α, IL-1β, and IL-10. These results indicate that the composition of this invention has a certain ameliorative effect on metabolic abnormalities, fatigue, and weakened immunity related to endocrine disorders, and can be used to prepare foods, health foods, or pharmaceutical preparations for regulating endocrine function.

Description

Technical Field

[0001] This invention relates to the fields of medicine, food and health products, and in particular to a food-medicine homology composition with endocrine-regulating function and its preparation method, as well as the application of the composition in the preparation of products that regulate endocrine function and improve related metabolic, fatigue and immune abnormalities. Background Technology

[0002] The endocrine system is the core network for maintaining homeostasis in the human body, regulating vital activities such as growth, development, metabolism, immunity, and reproduction through hormones. With the fast pace of modern life and chronic stress, endocrine disorders have become a common state of sub-health and disease. Among these, thyroid dysfunction (such as hyperthyroidism) can trigger a complex syndrome characterized by hypermetabolism, temperature imbalance, fatigue due to excessive energy expenditure, and secondary immunodeficiency.

[0003] Currently, clinical treatment for such endocrine abnormalities often involves intervention with chemically synthesized hormones or single-target targeted drugs. While these methods can control biochemical indicators in the short term, they easily lead to liver and kidney metabolic damage, drug resistance, and are ineffective in improving the systemic microenvironment deterioration commonly present in patients, such as chronic low-grade inflammation, intractable fatigue, and immune imbalance. The traditional Chinese medicine concept of "medicine and food sharing the same origin" provides direction for developing safe and gentle alternatives.

[0004] Chinese patent application CN120437251A discloses a traditional Chinese medicine composition for preventing and treating premature ovarian failure and its application. The disclosed composition includes Euryale ferox, Aquilaria sinensis, Sandalwood, processed Pinellia ternata, Rheum palmatum, Amomum villosum, Amomum cardamomum, processed Arisaema heterophyllum, processed Aconitum carmichaelii, Asarum heterotropoides, Citrus aurantium, and Piper longum. However, while the patent's efficacy is to regulate reproductive endocrine function, its formula contains several herbs with known toxicity, such as processed Pinellia ternata, processed Arisaema heterophyllum, processed Aconitum carmichaelii, and Asarum heterotropoides. These herbs must undergo strict processing to reduce their toxicity, and their clinical use often has specific dosage and treatment course limitations.

[0005] Chinese patent application CN120131886A discloses a traditional Chinese medicine preparation for menopausal syndrome caused by endocrine therapy in breast cancer patients. This patented preparation consists of Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Codonopsis pilosula, Cinnamomum cassia, Paeonia lactiflora, calcined dragon bone, calcined oyster shell, Acorus tatarinowii, Curcuma longa, processed turtle shell, ginger, and jujube. However, while this patent shows therapeutic efficacy for the side effects caused by endocrine therapy in a specific patient population (breast cancer patients), its effectiveness is highly targeted but lacks universality, failing to meet the general public's need for daily endocrine regulation.

[0006] Based on the above analysis of existing technologies, this paper proposes a safe, non-toxic, widely applicable endocrine regulator suitable for long-term consumption. This can fill the market gap in the field of daily health conditioning for the general public and also provide a new direction for the development of corresponding drugs or functional foods. Summary of the Invention

[0007] This invention provides a food-medicine homology composition and its application in regulating endocrine function. The composition is prepared by combining Polygonatum sibiricum, Dioscorea opposita, and Coix lacryma-jobi as base ingredients, along with Cornus officinalis, Lycium barbarum, Poria cocos, Nelumbo nucifera leaf, donkey-hide gelatin, Glycyrrhiza uralensis (processed), Ziziphus jujuba var. spinosa, and Citrus reticulata peel. Animal experiments show that this composition can improve symptoms such as weight loss, elevated body temperature, and decreased exercise tolerance in thyroxine-induced models, and can reduce serum T3, T4, and inflammation-related cytokines levels, suggesting a certain regulatory effect on endocrine disorders. This invention is specifically achieved through the following technical means.

[0008] This invention provides a food-medicine composition for regulating endocrine function, the raw materials of which include: Polygonatum sibiricum, Dioscorea opposita, Coix lacryma-jobi, Cornus officinalis, Lycium barbarum, Poria cocos, Nelumbo nucifera leaf, donkey-hide gelatin, Glycyrrhiza uralensis (processed), Ziziphus jujuba var. spinosa, and Citrus reticulata peel.

[0009] Furthermore, the raw materials of the food-medicine homology composition include, by mass parts: 6 parts Polygonatum sibiricum, 6 parts Dioscorea opposita, 6 parts Coix lacryma-jobi, 1.6-10 parts Cornus officinalis, 1.6-10 parts Lycium barbarum, 1.6-10 parts Poria cocos, 1.6-10 parts Nelumbo nucifera, 0.8-5 parts donkey-hide gelatin, 0.8-5 parts prepared licorice root, 0.4-2.5 parts Ziziphus jujuba var. spinosa, and 0.4-2.5 parts Citrus reticulata peel.

[0010] Furthermore, the raw materials of the food-medicine homology composition include, by mass parts: 6 parts Polygonatum sibiricum, 6 parts Dioscorea opposita, 6 parts Coix lacryma-jobi, 4 parts Cornus officinalis, 4 parts Lycium barbarum, 4 parts Poria cocos, 4 parts Nelumbo nucifera, 2 parts donkey-hide gelatin, 2 parts prepared licorice root, 1 part Ziziphus jujuba var. spinosa, and 1 part Citrus reticulata peel.

[0011] The medicinal and edible composition provided by this invention adopts the scientific and rigorous TCM diagnostic method and the principle of "principal, assistant, adjuvant, and guide" in its formulation. From the perspective of TCM, the medicinal and edible composition of this invention belongs to the category of "balanced tonification of the spleen and kidneys, simultaneous tonification of qi and yin, supplemented by the ascending of clear qi and descending of turbid qi, nourishing blood and calming the mind"; it targets the core pathogenesis of metabolic abnormalities, fatigue, and decreased immunity caused by endocrine disorders—"deficiency of the spleen and kidneys as the root, insufficiency of qi, blood, essence and body fluids, accompanied by phlegm, turbidity, and dampness stagnation." The entire formula combines tonification and purgation, harmonizing the five internal organs, with particular emphasis on the prenatal and postnatal foundations (spleen and kidneys).

[0012] In modern medicine, the composition of this invention is an intervention program that regulates the endocrine and metabolic networks through multiple targets and pathways. Its mechanisms of action include: regulating the hypothalamic-pituitary-target gland axis (improving fatigue and endocrine disorders), regulating glucose and lipid metabolism (reducing lipid levels), anti-oxidation and free radical scavenging (delaying aging), and enhancing the body's overall defense function by strengthening cellular and humoral immunity. All ingredients in the formula are of medicinal and edible origin, possessing extremely high safety for long-term use.

[0013] From the perspective of traditional Chinese medicine formulation, the composition of this invention uses Polygonatum sibiricum and Dioscorea opposita as the main tonic ingredients. Both are sweet and neutral in nature, and enter the spleen, lung, and kidney meridians, thus replenishing qi and nourishing yin, strengthening the spleen and benefiting the kidneys. Coix lacryma-jobi and Poria cocos strengthen the spleen and eliminate dampness, helping to reduce internal dampness and turbidity. Cornus officinalis and Lycium barbarum nourish the liver and kidneys, nourish yin and replenish essence, and can enhance the tonic effect when combined with Polygonatum sibiricum and Dioscorea opposita. Lotus leaf clears summer heat and dampness, and promotes the upward movement of clear yang; Citrus reticulata peel regulates qi, strengthens the spleen, dries dampness and resolves phlegm, which can reduce the stagnation that may be caused by tonic ingredients. Donkey-hide gelatin nourishes blood and yin, and Ziziphus jujuba var. spinosa nourishes the heart and calms the mind, making it suitable for people with endocrine disorders who often experience fatigue, poor sleep, and emotional tension. Prepared licorice root replenishes the middle jiao and benefits qi, and also plays a role in harmonizing the effects of the other herbs.

[0014] Therefore, the composition of the present invention is not simply a tonic, but rather, on the basis of tonifying the spleen and kidneys, it also takes into account strengthening the spleen and resolving dampness, regulating qi and harmonizing the middle jiao, nourishing blood and calming the mind, making it more suitable for metabolic abnormalities, fatigue and fluctuating immune function related to endocrine disorders.

[0015] Specifically, based on the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide" in prescription formulation:

[0016] (1) In this invention, the principal herbs are used to "strengthen the foundation and nourish the source, and gently replenish the three Yin meridians." Among them, Polygonatum sibiricum: sweet, neutral, enters the spleen, lung, and kidney meridians. It can replenish Qi and nourish Yin, and replenish essence and marrow. Modern research has confirmed that its rich polysaccharide components have significant immunomodulatory and anti-fatigue effects. Dioscorea opposita: sweet, neutral, enters the spleen, lung, and kidney meridians. It can strengthen the spleen and stomach, benefit the lungs and kidneys, and consolidate essence and Qi. The spleen is the foundation of acquired constitution, and the kidney is the foundation of innate constitution.

[0017] Both Polygonatum and Dioscorea are sweet and neutral in nature, and enter the spleen, lung, and kidney meridians together. They tonify the spleen to aid digestion and nourish the kidney yin to replenish Tian Gui (the basis of endocrine substances). Together, they gently tonify the three yin meridians without causing stagnation or greasiness, helping to improve pathological states such as fatigue, weakness, and low immunity.

[0018] (2) The herbal formulas are used to "nourish the kidneys and replenish essence, strengthen the spleen and eliminate dampness". Coix seed: sweet, bland, cool, enters the spleen, stomach and lung meridians. It can promote diuresis and eliminate dampness, strengthen the spleen and stop diarrhea. When using tonifying herbs, coix seed can clear damp heat in the lower burner and improve the "abnormal water metabolism" and "internal generation of phlegm" that often accompany endocrine disorders. Cornus officinalis: sour, slightly warm, enters the liver and kidney meridians. It nourishes the liver and kidneys, and astringes and consolidates. It can nourish the kidneys and replenish essence, nourish the liver and calm the liver, and prevent the secret depletion of essence and qi. Lycium barbarum: sweet, neutral, enters the liver and kidney meridians. It nourishes the liver and kidneys, replenishes essence and improves eyesight.

[0019] In the above-mentioned adjuvant herbs, Cornus officinalis and Lycium barbarum can enhance the principal herb's ability to replenish innate kidney essence and enrich the source of endocrine function; Coix seed works with the principal herb to strengthen the acquired spleen. These three adjuvant herbs combine tonification with regulation, and purgation with tonification, working together to assist the principal herb in exerting its efficacy.

[0020] (3) Adjuvant herbs are used for "raising clear qi and lowering turbid qi, nourishing blood and calming the mind, regulating qi and preventing stagnation". Poria: strengthens the spleen and calms the mind, promotes diuresis and eliminates dampness. When combined with Coix seed, it enhances the function of eliminating "dampness and turbidity" and reduces the metabolic burden on the body. Lotus leaf: clears heat and relieves summer heat, raises clear yang. Traditional Chinese medicine believes that "the spleen is healthy when it rises". Lotus leaf can raise the clear qi of the spleen and stomach and lower turbid fat. It is highly consistent with the effects of modern medicine in improving lipid metabolism and regulating endocrine obesity. Donkey-hide gelatin: sweet, neutral, enters the lung, liver and kidney meridians. It is a "product of blood and flesh", which can nourish blood and yin and moisten dryness. It provides deep nourishment for the yin and blood depletion that often accompanies endocrine disorders, so that qi and blood can be generated. Sour jujube seed: sweet, sour, neutral. Nourishes the heart and liver, calms the mind and stops sweating. People with endocrine disorders often experience emotional distress, insomnia, and vivid dreams. Sour jujube seed can calm the mind and soothe the nerves, improve the state of the central nervous system, and break the vicious cycle of "insomnia-endocrine deterioration." Dried tangerine peel: pungent, bitter, and warm. It regulates qi, strengthens the spleen, dries dampness, and resolves phlegm.

[0021] The above four auxiliary herbs, since the ingredients such as Polygonatum sibiricum, donkey-hide gelatin, and Cornus officinalis are mostly nourishing and greasy, the addition of a small amount of dried tangerine peel can regulate the flow of qi, invigorate the spleen and stomach, so that the whole formula can "nourish and digest", and will not harm the stomach even after long-term use.

[0022] (4) Used to "harmonize all medicines and protect the middle jiao". Prepared licorice: sweet, neutral, enters the heart, lung, spleen and stomach meridians. It tonifies the spleen and stomach, and replenishes qi and restores the pulse.

[0023] The medicinal licorice root plays a crucial role in the formula, not only assisting the principal and assistant herbs in replenishing the middle qi, but more importantly, harmonizing the imbalances of cold, heat, warmth, and coolness. It integrates the medicinal power of all eleven herbs in the formula, guiding them to their respective meridians and organs to exert a stable and lasting regulatory effect.

[0024] From the perspective of modern medicine and pharmacology, the raw materials such as Polygonatum sibiricum, Lycium barbarum, and Dioscorea opposita in the composition of this invention contain polysaccharides; Cornus officinalis contains iridoid glycosides; Ziziphus jujuba var. spinosa contains saponins; and Nelumbo nucifera leaf and Citrus reticulata peel contain flavonoids or volatile components. These components may collectively participate in processes such as metabolic regulation, antioxidation, regulation of inflammatory factors, and regulation of central nervous system function. Combined with animal experimental results, the composition of this invention has an improving effect on symptoms such as thyroid hormone-induced abnormal hormone levels, weight loss, elevated body temperature, and decreased exercise endurance. The medicinal and edible homologous composition provided by this invention breaks through the limitations of single-component formulations, and comprehensively intervenes in endocrine disorders and related metabolic and immune fatigue problems through the following multi-link, multi-target synergistic effects:

[0025] (1) Bidirectional regulation of the endocrine axis.

[0026] Polygonatum, Dioscorea, Cornus officinalis, and Lycium barbarum are rich in active ingredients such as polysaccharides, steroidal saponins, and iridoid glycosides. Modern pharmacology has confirmed that these components can effectively regulate the function of the hypothalamus-pituitary-adrenal / gonadal axis, improve hormonal imbalances (such as disorders of cortisol and sex hormone levels), block the cascade reaction of endocrine disorders from the upstream source, and delay glandular aging.

[0027] (2) Anti-fatigue, anti-oxidation and immune remodeling.

[0028] Polysaccharides from Polygonatum sibiricum, Lycium barbarum, and donkey-hide gelatin (rich in specific amino acids and collagen) provide powerful nutritional support and promote hematopoiesis. They not only eliminate excess free radicals in the body and reduce cellular oxidative stress damage, but also increase liver / muscle glycogen reserves, lower blood lactate levels, and reverse chronic fatigue syndrome at the cellular level. Simultaneously, they promote macrophage phagocytosis and lymphocyte proliferation, comprehensively enhancing the body's immunity.

[0029] (3) Sedative and calming effects on the central nervous system and rhythm regulation.

[0030] Sour jujube seed (rich in jujube seed saponins) works synergistically with Poria cocos to regulate central neurotransmitters, exerting significant sedative, hypnotic, and anti-anxiety effects. By improving sleep structure and relieving mental tension, it breaks the vicious cycle of "sleep disorders / emotional stress-endocrine imbalance," providing the necessary physiological rhythm environment for the self-repair of the body's endocrine system.

[0031] In summary, the composition of this invention strictly adheres to the treatment principle of "tonifying the spleen and kidneys to treat the root cause, strengthening the spleen and eliminating dampness to treat the symptoms, and nourishing blood and calming the mind to regulate the spirit." Its structure is rigorous, with clear distinctions between the principal, assistant, and adjuvant components. It intervenes at multiple targets through three key aspects: "regulating the hormonal neural axis, enhancing anti-fatigue immunity, and improving sleep rhythm." The components work synergistically to achieve comprehensive management of endocrine homeostasis and overall metabolic health.

[0032] This invention also provides a method for preparing the above-mentioned food-medicine homology composition for regulating endocrine function, characterized by comprising the following steps:

[0033] The powders of Cornus officinalis, Coix lacryma-jobi, and Poria cocos were extracted with water for the first time, and the first filtrate and the first residue were collected.

[0034] Add powders of Polygonatum sibiricum, Dioscorea opposita, Lycium barbarum, Nelumbo nucifera, Colla corii asini, Glycyrrhiza uralensis, Ziziphus jujuba var. spinosa, and Citrus reticulata to the first filter residue. Add water for the second extraction, filter, and collect the second filtrate and the second filter residue.

[0035] The first and second filter residues are combined, and water is added for a third extraction. The mixture is then filtered to obtain the third filtrate.

[0036] The first, second, and third filtrates were combined, concentrated, and spray-dried to obtain the extract of the composition of the present invention.

[0037] Furthermore, the first water extraction method is as follows: add 6-15 times the total mass of Cornus officinalis, Coix lacryma-jobi, and Poria cocos to water, and decoct for 0.5-2 hours.

[0038] Furthermore, the second water extraction method is as follows: add 6-15 times the total mass of Polygonatum sibiricum, Dioscorea opposita, Lycium barbarum, Nelumbo nucifera, Colla corii asini, Glycyrrhiza uralensis, Ziziphus jujuba var. spinosa, and Citrus reticulata var. tangerine peel to water, and decoct for 0.5-2 hours.

[0039] Furthermore, the third water extraction method is as follows: add water at a ratio of 6-15 times the total mass of the first and second filter residues, and decoct for 1-2.5 hours.

[0040] The present invention also provides the application of the above-mentioned food and medicine homology composition for the preparation of products that improve fatigue and / or low immune function caused by endocrine disorders.

[0041] The present invention also provides a product for improving fatigue and / or weakened immune function caused by endocrine disorders, which is prepared from a combination of food and medicine homology as raw materials.

[0042] Furthermore, the product is an oral liquid, granules, tablets, capsules, pills, powders, or extracts.

[0043] Furthermore, the product is used to regulate thyroid hormone levels and / or suppress inflammatory responses.

[0044] Furthermore, the regulation of thyroid hormone levels includes reducing serum levels of T3 and T4.

[0045] Furthermore, the inhibition of the inflammatory response includes reducing serum levels of IL-6, TNF-α, IL-1β, and IL-10.

[0046] Compared with the prior art, the advantages of the present invention are:

[0047] 1. The raw material composition is clearly defined, and the formulation has the characteristics of overall regulation.

[0048] The composition of this invention comprises Polygonatum sibiricum, Dioscorea opposita, Coix lacryma-jobi, Cornus officinalis, Lycium barbarum, Poria cocos, Nelumbo nucifera leaf, donkey-hide gelatin, prepared licorice root, Ziziphus jujuba var. spinosa, and Citrus reticulata peel. The ingredients have a compatibility relationship of tonifying the spleen and kidneys, strengthening the spleen and resolving dampness, nourishing blood and calming the mind, and regulating qi and harmonizing the middle jiao.

[0049] Animal model validation results show that the composition can not only target and intervene in endocrine disorders and effectively downregulate the abnormally elevated levels of thyroid hormones such as T3 and T4 in peripheral blood, but also alleviate symptoms such as weight loss, elevated body temperature and reduced exercise endurance in animals.

[0050] 2. Treat both the symptoms and the root cause, and improve the body's overall condition by regulating endocrine function.

[0051] This invention provides a gentler and more comprehensive intervention pathway: while alleviating abnormal hormone secretion, the preparation can significantly reduce the body's chronic low-grade inflammatory state (specifically, by significantly inhibiting the levels of inflammatory factors such as IL-6, TNF-α, IL-1β, and IL-10). This multi-dimensional intervention model is highly consistent with the complex clinical signs of "metabolic disorders - weakness and fatigue - weakened immunity" commonly found in people with endocrine disorders.

[0052] 3. By integrating the mechanisms of traditional Chinese and Western medicine, a new treatment network that addresses both the symptoms and the root cause can be constructed.

[0053] The development of this composition integrates the essence of modern life sciences with the diagnostic and treatment principles of traditional Chinese medicine. From a modern pharmacological perspective, the formulation components can dynamically intervene in the hypothalamus-pituitary-target gland axis, playing a positive role in antioxidation, central nervous system sedation, and circadian rhythm remodeling. From the perspective of traditional Chinese medicine principles, methods, and prescriptions, the entire formula adheres to the core treatment principles of "tonifying the spleen and kidneys to strengthen the foundation, invigorating the spleen and eliminating dampness to treat the symptoms, and nourishing blood and calming the mind to regulate the heart." Through the means of "tonifying qi and nourishing yin, and promoting the ascending of clear qi and descending of turbid qi," it promotes the biochemical processes and circulation of essence, qi, blood, and body fluids in the human body. This holistic approach to the mechanism analysis provides a solid theoretical foundation for the clinical translational value of the product.

[0054] 4. The raw materials are safe and the dosage form is highly compatible.

[0055] This invention strictly adheres to the national catalogue of food and medicine homology, using only traditionally consumed natural foods and medicinal materials with well-defined pharmacological properties. This fundamentally avoids the safety risks associated with toxic medicinal materials, ensuring long-term safety. The extraction and molding processes of this invention are mature and stable, allowing for the creation of diverse modern dosage forms such as oral liquids, granules, capsules, or tablets. This not only overcomes the drawbacks of traditional Chinese medicine decoctions—time-consuming, labor-intensive, and having poor patient compliance—but also greatly facilitates daily health management for fast-paced individuals. The applicable scope of this composition extends beyond patients with endocrine disorders to include the vast sub-healthy population, fully embodying the advanced concept of "prevention of disease" in traditional Chinese medicine, and possessing promising prospects for commercial development and health applications. Attached Figure Description

[0056] Figure 1 A schematic diagram for designing animal experiments.

[0057] Figure 2 This is a graph showing the changes in body weight of mice in each group during the experimental period.

[0058] Figure 3 This is a graph showing the changes in body temperature of mice in each group during the experimental period.

[0059] Figure 4 This is a comparison of the exhaustion swimming time of mice in each group after treatment.

[0060] Figure 5 The graph shows the results of serum T3 and T4 level detection in each group of mice.

[0061] Figure 6 The graph shows the results of serum inflammatory cytokine levels in mice from each group. Detailed Implementation

[0062] The technical solution of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0063] Example 1

[0064] The medicinal and edible composition provided in this embodiment is made by accurately weighing the following raw materials that meet the standards of the Chinese Pharmacopoeia according to the mass proportions: 6 parts of Polygonatum sibiricum, 6 parts of Dioscorea opposita, 6 parts of Coix lacryma-jobi, 4 parts of Cornus officinalis, 4 parts of Lycium barbarum, 4 parts of Poria cocos, 4 parts of Nelumbo nucifera, 2 parts of donkey-hide gelatin, 2 parts of prepared licorice root, 1 part of Ziziphus jujuba var. spinosa, and 1 part of Citrus reticulata peel.

[0065] The preparation method of the above-mentioned food-medicine homology composition is as follows:

[0066] (1) The above raw materials are pulverized at low temperature and passed through an 80-mesh sieve.

[0067] (2) First decoction: Take the powders of Cornus officinalis, Coix lacryma-jobi and Poria cocos, add 10 times the total mass of the above three medicinal materials in pure water, soak at room temperature for 30 minutes, then reflux at 100℃ for 1 hour, filter, and collect the first filtrate and the first residue.

[0068] (3) Second decoction: Add Polygonatum, Dioscorea opposita, Lycium barbarum, Nelumbo nucifera, Colla corii asini, Glycyrrhiza uralensis, Ziziphus jujuba var. spinosa and Citrus reticulata powder to the dregs after the first decoction, and then add 10 times the total mass of the above 8 medicinal materials in pure water. Reflux at 100°C for 1 hour, filter, and collect the second filtrate and the second filter residue.

[0069] (4) Re-extraction of the residue: Combine the first and second filter residues, add 10 times the total mass of the first and second filter residues of pure water, extract for 1.5 hours under the same conditions, filter, and collect the filtrate.

[0070] (6) Combining and drying: Combine all stage filtrates, concentrate under reduced pressure and then spray dry to finally obtain the extract powder of the composition of the present invention.

[0071] Example 2

[0072] The medicinal and edible composition provided in this embodiment includes the following raw materials in parts by weight: 6 parts Polygonatum sibiricum, 6 parts Dioscorea opposita, 6 parts Coix lacryma-jobi, 1.6 parts Cornus officinalis, 1.6 parts Lycium barbarum, 1.6 parts Poria cocos, 1.6 parts Nelumbo nucifera, 0.8 parts donkey-hide gelatin, 0.8 parts prepared licorice root, 0.4 parts Ziziphus jujuba var. spinosa, and 0.4 parts Citrus reticulata peel.

[0073] The preparation method of the food-medicine homology composition used in this embodiment is the same as that in Example 1.

[0074] Example 3

[0075] The medicinal and edible composition provided in this embodiment includes the following raw materials in parts by weight: 6 parts Polygonatum sibiricum, 6 parts Dioscorea opposita, 6 parts Coix lacryma-jobi, 10 parts Cornus officinalis, 10 parts Lycium barbarum, 10 parts Poria cocos, 10 parts Nelumbo nucifera, 5 parts donkey-hide gelatin, 5 parts prepared licorice root, 2.5 parts Ziziphus jujuba var. spinosa, and 2.5 parts Citrus reticulata peel.

[0076] The preparation method of the food-medicine homology composition used in this embodiment is the same as that in Example 1.

[0077] Comparative Example 1

[0078] The medicinal and edible composition provided in this comparative example differs from that in Example 1 in that the principal ingredient "Polygonatum sibiricum" is replaced with an equal mass of "ginseng", and the assistant ingredient "Coix lacryma-jobi" is replaced with an equal mass of "Atractylodes macrocephala".

[0079] The basis for the replacement is that ginseng and atractylodes macrocephala are a classic combination for tonifying vital energy and strengthening the spleen. However, the core pathogenesis of endocrine disorders (especially hyperthyroidism and other hypermetabolic states) is "deficiency of both qi and yin, yin deficiency with fire excess, and concurrent damp-heat." Ginseng is slightly warm in nature, while atractylodes macrocephala is warm and drying. Although the combination of the two can tonify qi, it lacks the "balanced tonification and clearing" effect of "Polygonatum sibiricum and Coix lacryma-jobi" in the original formula, which can both nourish yin and moisten dryness, and clear heat and eliminate dampness.

[0080] The preparation method of the food-medicine homology composition is the same as that in Example 1.

[0081] Comparative Example 2

[0082] The medicinal and edible composition provided in this comparative example differs from that in Example 1 in that the adjuvant herbs "Poria cocos and lotus leaf" which play the core role of "raising the clear and lowering the turbid" are replaced with the same mass of traditional yin-nourishing herbs "Ophiopogon japonicus and Polygonatum odoratum".

[0083] The replacement is based on the fact that while Ophiopogon japonicus and Polygonatum odoratum enhance the overall yin-nourishing and heat-clearing effects of the formula, they lack the spleen-strengthening and dampness-draining functions of Poria cocos and the lipid-releasing and lipid-clearing functions of Nelumbo nucifera. Patients with endocrine disorders often suffer from severe lipid and glucose metabolism disorders and the accumulation of metabolic waste (what Traditional Chinese Medicine calls "phlegm-dampness accumulation"). The original formula's efficacy lies in "nourishing yin without forgetting to resolve turbidity, and tonifying without forgetting to unblock." After the replacement, the entire formula becomes rich and heavy, lacking pathways for the transformation and elimination of phlegm-dampness. This not only makes it difficult to repair the intestinal microecology but also easily leads to poor absorption, failing to achieve the expected improvement of inflammation and metabolic indicators from the source.

[0084] The preparation method of the food-medicine homology composition is the same as that in Example 1.

[0085] Comparative Example 3

[0086] The medicinal and edible composition provided in this comparative example differs from that in Example 1 only in that the kidney-tonifying and essence-replenishing herbs Cornus officinalis and Lycium barbarum are replaced with an equal mass of the yin-nourishing herb Rehmannia glutinosa.

[0087] The rationale for replacement is as follows: While Rehmannia glutinosa is a commonly used herb for nourishing the liver and kidneys and replenishing essence and marrow, it is also considered to be somewhat cloying in nature. Patients with endocrine disorders (such as hyperthyroidism and other hypermetabolic states) often experience weakened spleen and stomach function due to long-term pathological depletion. The original formula of this invention uses Cornus officinalis, which is sour and astringent, and Lycium barbarum, which is sweet and mild, moistening. While nourishing the liver and replenishing the endocrine system, it also maintains the characteristic of being "nourishing without being cloying." If Rehmannia glutinosa is replaced with Rehmannia glutinosa, prolonged use may impair stomach qi, affecting the absorption and transformation of essential substances by the spleen in the middle jiao, resulting in "nourishing without promoting circulation." This not only fails to effectively improve fatigue and physical strength but may also easily generate damp heat.

[0088] The preparation method of this composition is exactly the same as that in Example 1.

[0089] Comparative Example 4

[0090] This comparative example provides a food-medicine composition that differs from Example 1 only in that the licorice root, which plays a harmonizing role in the formula, is replaced with an equal mass of jujubes.

[0091] The rationale for substitution is that in the original formula, prepared licorice root primarily serves to harmonize the overall effect, making the medicinal power mild and long-lasting. While jujube also has the effect of tonifying the middle jiao and replenishing qi, it is sweet and warm in nature, and excessive consumption can easily lead to bloating of the middle jiao. This comparative study aims to verify the necessity of using prepared licorice root as the guiding herb in the original formula in harmonizing the overall properties of the formula and stabilizing its metabolic regulatory effects.

[0092] The preparation method of this composition is exactly the same as that in Example 1.

[0093] Experimental Example: Pharmacological Evaluation of the Compositions Prepared in the Examples and Comparative Examples

[0094] 1. Experimental animals

[0095] SPF-grade male KM mice (8 weeks old, weighing 20±2 g) were purchased from Liaoning Changsheng Biotechnology Co., Ltd. Animal housing conditions were: room temperature 25℃, relative humidity 55%-60%, 16 h / 8 h light / dark alternation, and free access to sterile water and AIN-76A standard feed.

[0096] 2. Establishment of animal models of endocrine disorders and drug administration regimen

[0097] (1) Model building

[0098] like Figure 1 As shown, after 7 days of acclimatization, the mice were randomly divided into 8 groups of 10 mice each; these groups were named blank group, model group, positive control group, experimental group, comparative group 1, comparative group 2, comparative group 3, and comparative group 4. Except for the blank group, the other groups were administered thyroxine by gavage daily for 14 consecutive days to establish an endocrine disorder model.

[0099] (2) Drug intervention

[0100] like Figure 1 As shown, after successful modeling, the positive control group was given Liuwei Dihuang Pills (0.72 g / kg), the experimental group was given the extract powder prepared in Example 1 (1.1 g / kg), and the comparative groups 1, 2, 3 and 4 were given the extract powder prepared in the corresponding comparative groups (1.1 g / kg). The blank group and the model group were given the same volume of physiological saline once a day for 14 days.

[0101] 3. Detection Indicators and Methods

[0102] (1) Monitoring of physiological indicators.

[0103] Record changes in body weight and body temperature during the experiment.

[0104] (2) Exercise endurance test.

[0105] Thirty minutes after the last administration, a weighted swimming experiment was conducted. Mice swam in a 40 cm × 55 cm × 75 cm swimming tank with the water temperature maintained at 20 ± 5 ℃. The mice were given a lead weight of 5% of their body weight and were artificially encouraged to swim continuously. The time from the start of freestyle swimming to 5-8 seconds after fully entering the water was recorded as the exhaustion swimming time.

[0106] (3) Sample collection.

[0107] Two hours after the last administration, mice were enucleated to remove blood and then dissected. The collected mouse blood samples were allowed to stand at room temperature for 2 hours, then centrifuged at 2000×g for 20 minutes. The supernatant was collected, aliquoted, and stored at -80 ℃ for later use.

[0108] (4) Serum marker detection

[0109] The levels of thyroid hormones (T3, T4) and inflammatory factors (IL-6, TNF-α, IL-1β, IL-10) in serum were detected using an enzyme-linked immunosorbent assay (ELISA) kit. The specific steps were performed in accordance with the kit instructions.

[0110] 4. Results Analysis

[0111] (1) Changes in mouse body weight

[0112] Mouse weight changes as follows Figure 2 As shown in the figure, two weeks after the start of modeling (i.e., week 0), the body weight of mice in other groups showed a decreasing trend compared to the control group, indicating that the endocrine disorder model was successfully established.

[0113] After two weeks of treatment, the experimental group showed significantly better weight recovery than the model group (**, p < 0.01), and the recovery effect was better than that of the positive control group, proving that this preparation can effectively reverse metabolic abnormalities and weight loss caused by endocrine disorders.

[0114] Furthermore, the intervention results of the comparative groups further demonstrated the advantages of the formulation of this invention: the weight of the mice in Comparative Group 1 hardly recovered; the weight of the mice in Comparative Group 2 showed a slight increase, but it was still lower than that of the experimental group. The mice in Comparative Group 3 even experienced gastrointestinal adverse reactions such as loss of appetite and loose stools in the later stages of the intervention, and their weight recovery was extremely slow. The weight recovery rate of Comparative Group 4 was also lower than that of the experimental group. These results indicate that the original formula of this invention has a scientific formulation and synergistic effect in balancing "mild tonification" and "clearing turbidity."

[0115] (2) Changes in mouse body temperature

[0116] Changes in mouse body surface temperature, such as Figure 3 As shown in the figure. Two weeks after modeling (i.e., week 0), compared with the control group, the body temperature of mice in all other groups increased, indicating that thyroxine successfully induced a hypermetabolic and thermogenic endocrine hyperactivity state, and the model was successfully established.

[0117] Two weeks after treatment (i.e., week 2), the body temperature of mice in the experimental group steadily decreased and returned to near-normal baseline levels (no statistically significant difference compared with the blank group, p > 0.05). Its antipyretic and fever-reducing effects were not only significantly better than the model group (****, p < 0.0001), but also better than the positive control group, demonstrating that this preparation has a good regulatory effect on abnormal energy metabolism and suppressing internal heat.

[0118] Furthermore, the data from the control group directly demonstrate the rigor and synergistic advantages of the compatibility mechanism of this invention:

[0119] The comparative group 1, due to the warm and dry nature of the medicine, could not effectively "nourish yin and reduce fire" like the Polygonatum sibiricum, resulting in the deficiency fire not only not subsiding but also increasing. Its body temperature decreased very little in the second week, which was significantly worse than that of the experimental group (***, p < 0.001).

[0120] Although the comparative group 2 showed some effect of nourishing yin and reducing fever, and the body temperature dropped, the "strengthening the spleen and reducing turbidity" pathway was removed from the formula (poria and lotus leaf were missing), resulting in incomplete dissipation of stagnant heat in the body, and the body temperature was still significantly higher than that of the experimental group (**, p< 0.01).

[0121] The control group 3 had limited reduction in body temperature due to the accumulation of dampness and heat in the body, and their body temperature remained higher than that of the experimental group after the intervention.

[0122] In contrast, the four control groups lacked the harmonizing and guiding effect of roasted licorice root, which prevented the effective components of the formula from achieving maximum synergistic effect. This resulted in a significant reduction in the effect of suppressing the body's high metabolic heat, and their body temperature remained significantly higher than that of the experimental group after the intervention.

[0123] The above data demonstrates the irreplaceable role of the synergistic combination of "nourishing yin and moisturizing dryness" and "raising the clear and lowering the turbid" multi-target in the composition of the present invention in correcting the hypermetabolic state of endocrine disorders.

[0124] (3) Changes in the motor ability of mice

[0125] The results of the comparison of the swimming time of mice at exhaustion are as follows: Figure 4 As shown in the figure, after two weeks of intervention following modeling, the exhaustive swimming time of mice in the model group was shorter compared to the control group, indicating that the hyperendocrine hyperactivity (hypermetabolism) state led to severe energy overdraft and extreme fatigue, and the model characteristics were significant.

[0126] After two weeks of treatment, the exhaustive swimming time of the experimental group mice was significantly prolonged. Its anti-fatigue effect was not only significantly better than that of the model group (***, p < 0.001), but also significantly better than that of the positive control drug (*, p < 0.05), which proves that this preparation has a good regulatory effect on improving deep fatigue caused by excessive endocrine depletion and reshaping the body's energy metabolism.

[0127] Furthermore, the exhaustion swimming time of Comparative Group 1 was significantly lower than that of the Experimental Group (****, p < 0.0001), indicating that for fatigue caused by endocrine hyperactivity, simply using qi-tonifying medicines with warm and dry properties cannot replenish the deficiency of yin essence in the body, and the body is very prone to exhaustion after entering the water.

[0128] Although Comparative Example 2 showed slightly better endurance than Comparative Example 1, its swimming time was still significantly shorter than that of the experimental group (****, p < 0.0001). This indirectly confirms the TCM theory of "phlegm-dampness trapping," which states that if the formula lacks key medicinal materials that drain dampness and reduce turbidity, it will lead to poor circulation of Qi in the body, hindered energy conversion efficiency, and a significant reduction in the overall anti-fatigue effect.

[0129] In the control group 3, due to obstructed spleen and stomach function and insufficient production of qi and blood, the mice had extremely poor endurance recovery and their exhaustion swimming time was significantly slower than that of the experimental group.

[0130] In the comparative group 4, the absence of the harmonizing effect of prepared licorice root meant that the effective components could not exert their maximum synergistic effect, resulting in a significant reduction in their anti-fatigue effect. This demonstrates the crucial role of the "guide herb" in stimulating the overall efficacy of the original formula.

[0131] The experimental data above demonstrate that simply replenishing Qi (Comparative Example 1) or simply nourishing Yin (Comparative Example 2), as well as improper combinations (Comparative Example 3 and Comparative Example 4), cannot maximize the restoration of the body's physical strength. The combination of the composition of the present invention can effectively reverse the fatigue state caused by endocrine disorders.

[0132] (4) Changes in thyroid function in mice

[0133] like Figure 5 As shown, compared with the normal control group, the serum levels of T3 and T4 in the model group mice were increased, indicating that the hypermetabolism and endocrine axis disorder model induced by thyroxine was successfully established.

[0134] After treatment, the experimental group showed a significant reduction in abnormally elevated T3 and T4 levels (compared to the model group, **, p < 0.01; ****, p < 0.0001), approaching the normal baseline. Particularly in its regulatory effect on the core T4 indicator, the experimental group showed a significantly better downregulation effect than the classic positive control group (*, p < 0.05), demonstrating that this preparation can effectively inhibit abnormal thyroid hormone secretion and restore endocrine homeostasis.

[0135] Furthermore, in Comparative Group 1, the medicinal properties were primarily focused on simple warming and tonifying, failing to exert the core efficacy of "nourishing yin and reducing fire" like those of Polygonatum. Faced with hyperthyroidism and its associated deficiency fire, it not only failed to suppress the abnormal excitation of the hypothalamus-pituitary-thyroid axis but also resulted in persistently high levels of T3 and T4 hormones. Its regulatory effect was significantly inferior to that of the experimental group in this invention (T3 index: **, p < 0.01; T4 index: ***, p < 0.001). This confirms that simply warming and tonifying the spleen cannot correct the core pathogenesis of endocrine hyperactivity.

[0136] Although the two comparative groups showed a certain trend of hormone downregulation due to the enhanced Yin-nourishing and heat-clearing properties, the "strengthening the spleen and eliminating dampness, promoting the ascending of clear Qi and descending of turbid Qi" pathway was disrupted, leading to "phlegm and turbidity accumulation and Qi stagnation" in the body, and a decrease in the efficiency of hormone metabolic waste excretion. The recovery of their T3 and T4 levels was significantly less than that of the experimental group of this invention (T3 index: *, p < 0.05; T4 index: **, p < 0.01).

[0137] Comparative groups 3 and 4 showed significant instability in their ability to downregulate core indicators such as T3 and T4, with a significantly weaker regulatory effect than the experimental group.

[0138] The above data proves that the composition of the present invention restores the stable level of thyroid hormones through a multi-dimensional intervention system of "both replenishing qi and yin" and "strengthening the spleen and resolving turbidity".

[0139] (5) Changes in the level of inflammatory factors

[0140] like Figure 6 As shown, compared with the control group, the serum levels of IL-6, TNF-α, IL-1β, and IL-10 in the model group mice were all elevated. This indicates that the thyroxine-induced hypermetabolic state triggered a strong chronic low-grade inflammatory response and impaired immune function, suggesting successful model establishment.

[0141] After two weeks of intervention, both the positive control group and the experimental group of this invention significantly downregulated the abnormally elevated levels of four inflammatory factors. The regulatory effects of the experimental group on IL-6, TNF-α, IL-1β, and IL-10 were roughly the same as those of the classic positive control group (Liuwei Dihuang Wan) (no significant difference between groups, p > 0.05), and all levels had returned to near the normal levels of the blank control group. This indicates that the composition of this invention can reduce the levels of inflammation-related factors and restore the body's immune balance.

[0142] The two sets of comparative data in the figure demonstrate the scientific nature and synergistic effect of this invention in the "principal, assistant, adjuvant, and guide" combination:

[0143] Comparative example 1 data showed that its IL-6, TNF-α, IL-1β, and IL-10 levels were at the same high level as the model group. This is because when people with a warm and dry constitution participated in the combination of Atractylodes macrocephala to deal with the "yin deficiency and fire excess" of endocrine hyperactivity, the deficiency heat could not be effectively cleared. This result proves that simple warming and tonifying cannot completely block the inflammatory cascade reaction.

[0144] In comparison group 2, the yin-nourishing and heat-clearing properties of this group were enhanced, and the four inflammatory factor indicators decreased compared to the model group. However, because the formula excluded the "spleen-strengthening and dampness-draining, clearing and turbidity-reducing" pathways of Poria cocos and lotus leaf, "phlegm and turbidity" accumulated in the body, and the inflammatory mediators were not completely eliminated. Therefore, the decrease in the levels of various inflammatory factors was limited, and ultimately still significantly higher than that of the experimental group in this application.

[0145] Due to the moderating effect of the drugs, the downregulation effect of comparative groups 3 and 4 on inflammatory factors such as IL-6 and TNF-α was unstable, and their overall anti-inflammatory performance was significantly weaker than that of the experimental group.

[0146] The above results indicate that the food-medicine composition of the present invention exhibits a positive regulatory effect on inflammatory factors through the balance and synergy of "mild tonification (nourishing yin without causing dryness)" and "clearing turbidity (clearing heat and eliminating metabolic waste)".

[0147] This experiment used the classic formula Liuwei Dihuang Wan as a positive control. The results show that the composition of this invention has good effects on improving weight loss, elevated body temperature, decreased exercise endurance, and regulating T3 and T4 levels in model animals. The experimental results are consistent with traditional Chinese medicine formula theory, as detailed below:

[0148] (1) Applicable to complex pathogenesis: Liuwei Dihuang Wan advocates "three tonifications and three purgations", focusing on nourishing kidney yin, and is suitable for simple kidney yin deficiency. However, the hypermetabolism caused by endocrine disorders such as hyperthyroidism is clinically characterized by "deficiency of both qi and yin, mixed with phlegm and turbidity". If Liuwei Dihuang Wan is used alone to nourish yin, it is often difficult to take into account the transportation and transformation function of the spleen in the middle jiao. This invention is based on the treatment method of "balanced tonification of spleen and kidney, ascending clear and descending turbid", with Polygonatum and Dioscorea as the chief herbs, which not only nourish kidney yin, but also strengthen the spleen and benefit qi; and is supplemented with Poria, lotus leaf, coix seed and other dampness-draining herbs to promote the excretion of pathological products (dampness and turbidity). This combination of "tonifying both qi and yin and combining tonification and purgation" is more in line with the current clinical characteristics of endocrine and metabolic disorders than simply nourishing yin.

[0149] (2) Improving gastrointestinal compliance: Liuwei Dihuang Pills heavily utilize Rehmannia glutinosa, which is greasy and nourishing. Long-term use can easily impair the stomach and spleen, causing adverse reactions such as abdominal distension and poor appetite. It has certain limitations for patients with endocrine disorders who often suffer from nutrient loss or intestinal microecological imbalance. Based on the verification results of Comparative Example 2, this composition selects Polygonatum sibiricum, Dioscorea opposita, and Lycium barbarum, which are sweet and neutral in nature and nourish without causing stagnation, as the main nourishing ingredients; combined with Citrus reticulata peel to regulate qi and invigorate the spleen, and Ziziphus jujuba var. spinosa to calm the mind and regulate rhythm.

[0150] (3) Synergistic effect of multiple targets: Experimental data show that Liuwei Dihuang Pills have relatively limited effects in restoring T3 and T4 levels and improving systemic inflammation (such as IL-6 and TNF-α). In contrast, the composition of this invention exhibits the characteristics of synergistic intervention through multiple pathways: it not only significantly restores thyroid hormone levels (the downregulation effect is better than that of positive control drugs), but also significantly reduces the levels of various inflammation-related cytokines, and significantly prolongs the time animals spend swimming to exhaustion (such as...). Figure 4 (As shown). In summary, this composition can exert its effects simultaneously from multiple dimensions, such as regulating endocrine homeostasis, improving the inflammatory microenvironment, and restoring energy metabolism, demonstrating the advantages of a formulation that addresses both the symptoms and the root cause.

[0151] The above detailed embodiments describe the implementation of the present invention; however, the present invention is not limited to the specific details described in the above embodiments. Within the scope of the claims and technical concept of the present invention, various simple modifications and changes can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

Claims

1. A medicinal and edible composition for regulating endocrine function, characterized in that, Its ingredients include: Polygonatum sibiricum, Dioscorea opposita, Coix lacryma-jobi, Cornus officinalis, Lycium barbarum, Poria cocos, Nelumbo nucifera leaf, donkey-hide gelatin, prepared licorice root, Ziziphus jujuba var. spinosa, and dried tangerine peel.

2. The medicinal and edible composition for regulating endocrine function according to claim 1, characterized in that, The raw materials, by weight, include: 6 parts Polygonatum sibiricum, 6 parts Dioscorea opposita, 6 parts Coix lacryma-jobi, 1.6-10 parts Cornus officinalis, 1.6-10 parts Lycium barbarum, 1.6-10 parts Poria cocos, 1.6-10 parts Nelumbo nucifera, 0.8-5 parts donkey-hide gelatin, 0.8-5 parts prepared licorice root, 0.4-2.5 parts Ziziphus jujuba var. spinosa, and 0.4-2.5 parts dried tangerine peel.

3. The medicinal and edible composition for regulating endocrine function according to claim 2, characterized in that, The ingredients, by weight, include: 6 parts Polygonatum sibiricum, 6 parts Dioscorea opposita, 6 parts Coix lacryma-jobi, 4 parts Cornus officinalis, 4 parts Lycium barbarum, 4 parts Poria cocos, 4 parts Nelumbo nucifera, 2 parts donkey-hide gelatin, 2 parts prepared licorice root, 1 part Ziziphus jujuba var. spinosa, and 1 part dried tangerine peel.

4. A method for preparing a medicinal and edible composition for regulating endocrine function as described in any one of claims 1-3, characterized in that, Includes the following steps: The powders of Cornus officinalis, Coix lacryma-jobi, and Poria cocos were extracted with water for the first time, and the first filtrate and the first residue were collected. Add powders of Polygonatum sibiricum, Dioscorea opposita, Lycium barbarum, Nelumbo nucifera, Colla corii asini, Glycyrrhiza uralensis, Ziziphus jujuba var. spinosa, and Citrus reticulata to the first filter residue. Add water for the second extraction, filter, and collect the second filtrate and the second filter residue. The first and second filter residues are combined, and water is added for a third extraction. The mixture is then filtered to obtain the third filtrate. The first, second, and third filtrates were combined, concentrated, and spray-dried to obtain the extract of the composition of the present invention.

5. The method for preparing the medicinal and edible composition for regulating endocrine function according to claim 4, characterized in that, The first water extraction method is as follows: add 6-15 times the total weight of Cornus officinalis, Coix lacryma-jobi, and Poria cocos to water, and decoct for 0.5-2 hours.

6. The method for preparing the medicinal and edible composition for regulating endocrine function according to claim 4, characterized in that, The second water extraction method is as follows: add 6-15 times the total mass of Polygonatum sibiricum, Dioscorea opposita, Lycium barbarum, Nelumbo nucifera, Colla corii asini, Glycyrrhiza uralensis, Ziziphus jujuba var. spinosa, and Citrus reticulata peel to water, and decoct for 0.5-2 hours.

7. The method for preparing the medicinal and edible composition for regulating endocrine function according to claim 4, characterized in that, The third water extraction method is as follows: add 6-15 times the total mass of the first and second filter residues of water, and decoct for 1-2.5 hours.

8. The application of the medicinal and edible composition according to any one of claims 1-3, characterized in that, Used to prepare products that improve fatigue and / or weakened immune function caused by endocrine disorders.

9. A product for improving fatigue and / or weakened immune function caused by endocrine disorders, characterized in that, It includes the food-medicine homology composition according to any one of claims 1-3; or it includes the food-medicine homology composition prepared by the preparation method according to any one of claims 4-6.

10. The product for improving fatigue and / or weakened immune function caused by endocrine disorders according to claim 9, characterized in that, The product is used to regulate thyroid hormone levels and / or suppress inflammatory responses; Furthermore, the regulation of thyroid hormone levels includes reducing serum T3 and T4 levels; Furthermore, the inhibition of the inflammatory response includes reducing serum levels of IL-6, TNF-α, IL-1β, and IL-10.

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