Pharmaceutical formulations for the treatment of rheumatic diseases and methods of use

Abstract

This invention relates to a medicinal formula for treating rheumatic bone diseases, comprising: *Tianqingdihong*, *Lulutong*, *Taibai Sanqi*, *Moyao*, *Qinghai Fangfeng*, *Bajiaofeng* root, *Meishuo* root, *Weilingxian* root, *Duyiwei*, *Jiulixiang* root, *Qianghuo*, *Yanhusuo*, *Baizhi*, *Bawangqi*, *Chaigui*, *Liufangteng*, *Qingfengteng*, *Niuteng*, *Wukoushu*, *Guimaozhen*, *Daxueteng*, *Chuangenteng*, *Xiatianwu*, *Sangzhi*, *Huangjueshu* root, *Chuanposhi* root, *Xuchangqing*, *Cansha*, *Guihuashu* root, *Liuyejianxuefei*, *Tongjingcao*, *Sheyancao*, *Fangji*, *Niudedu* root, *Shanmei*, *Junong*, *Lijiangshancigu*, *Linwenjing*, *Sanjiapi*, *Gouteng* root, *Wujiapi*, *Yijuye*, *Ziwei* root, *Ziteng* root, *Daphne* leaf, *Zimu*, *Jimucao*, *Jiegudan*, *Shenjincao*, *Shujincao*, *Choumudan*, *Jixueteng*, *Honghua*, *Duzhong*, *Niumateng*, *Biandanteng*, and *Jianghuang*. The present invention also provides a method for using the formula.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, specifically to a drug formulation and method of use for treating rheumatic bone diseases. Background Technology

[0002] Rheumatic bone disease is a systemic disease caused by wind and cold obstructing blood circulation, leading to lesions in muscles, ligaments, bursae, and other tissues. It is common in young adults aged 20-45. Patients often develop the disease due to factors such as cold, dampness, and fatigue. Symptoms include joint pain and swelling, limited mobility, and a chronic, recurrent course. Some cases may progress to joint deformities or loss of function.

[0003] Currently, the treatment of rheumatic bone diseases often involves a combination of nonsteroidal anti-inflammatory drugs (NSAIDs) and common rheumatic plasters. However, this treatment method has drawbacks such as low efficacy and high recurrence rate. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a drug formulation and method of use for treating rheumatic bone diseases, so as to solve the technical problems of low efficacy and high recurrence rate of existing treatments for rheumatic bone diseases.

[0005] This invention is achieved through the following technical solution: A medicinal formula for treating rheumatic bone diseases is composed of the following traditional Chinese medicine raw materials in the indicated weight ratios: 5-15 parts of Tianqingdihong; 10-20 parts of Lulutong; 5-15 parts of Taibai Sanqi; 5-15 parts of Moyao; 5-15 parts of Qinghai Fangfeng; 10-20 parts of Bajiaofeng root; 10-20 parts of Meigui root; 10-20 parts of Weilingxian root; 5-15 parts of Duyiwei; 25-35 parts of Jiulixiang root; 10-20 parts of Qianghuo; 10-20 parts of Yanhusuo; 10-20 parts of Baizhi; 10-20 parts of Bawangqi. ; Cinnamomum cassia 5-15 parts; Vine of six directions 25-35 parts; Vine of clear breeze 10-20 parts; Vine of ox 25-35 parts; Cinnamomum camphora 25-35 parts; Gynostemma pentaphyllum 10-20 parts; Vine of large blood vine 10-20 parts; Vine of piercing roots 25-35 parts; Summer pine 10-20 parts; Mulberry branches 15-25 parts; Root of Juglans regia 15-25 parts; Root of Stone-piercing Stone 25-35 parts; Cynanchum paniculatum 5-15 parts; Silkworm excrement 15-25 parts; Osmanthus root 25-35 parts; Willow leaf Antiaris toxicaria 25-35 parts; Mentholatum 10-20 parts; Eclipta prostrata 10-20 parts; Stephania tetrandra 5-15 parts; Achyranthes bidentata root 25-35 parts; Raspberry 10-20 parts; Juniper 10-20 parts; Lijiang Mountain Pseudobulbus Cremastrae 0.4-0.8 parts; Horsetail 5-15 parts; Acanthopanax senticosus 25-35 parts; Uncaria rhynchophylla root 20-30 parts; Acanthopanax senticosus 5-15 parts; Blueberry leaf 5- 15 parts; 5-15 parts of calendula root; 10-20 parts of wisteria root; 5-15 parts of daphne leaf; 5-15 parts of catalpa wood; 10-20 parts of sclerotium root; 10-20 parts of lycopodium; 10-20 parts of clematis root; 10-20 parts of clematis root; 10-20 parts of peony root; 15-25 parts of chicken blood vine; 10-20 parts of safflower; 10-20 parts of eucommia bark; 25-35 parts of oxtail vine; 25-35 parts of flat vine; 10-20 parts of turmeric.

[0006] Furthermore, the aforementioned drug formula for treating rheumatic bone diseases is composed of the following traditional Chinese medicine raw materials in the indicated weight ratios: 10 portions of Tianqingdihong; 15 portions of Lulutong; 10 portions of Taibai Sanqi; 10 portions of Moyao; 10 portions of Qinghai Fangfeng; 15 portions of Bajiaofeng root; 15 portions of Meigui root; 15 portions of Weilingxian root; 10 portions of Duyiwei; 30 portions of Jiulixiang root; 15 portions of Qianghuo; 15 portions of Yanhusuo; 15 portions of Baizhi; 15 portions of Bawangqi; 10 portions of Chai Gui; 30 portions of Liufangteng; 15 portions of Qingfengteng; 30 portions of Niuteng; 30 portions of Wukoushu; 15 portions of Guimaozhen; 15 portions of Daxueteng; 30 portions of Chuangenteng; 15 portions of Xiatianwu; 20 portions of Sangzhi; 20 portions of Huangjueshu root; 30 portions of Chuanposhi root; 10 portions of Xuchangqing; 20 portions of Cansha. ; Osmanthus root 30 parts; Willow leaf antiperspirant 30 parts; Mentholatum 15 parts; Snake eye grass 15 parts; Stephania tetrandra 10 parts; Strychnos nux-vomica root 30 parts; Raspberry 15 parts; Juniper 15 parts; Lijiang mountain wormwood 0.6 parts; Horsetail 10 parts; Acanthopanax senticosus 30 parts; Uncaria rhynchophylla root 25 parts; Acanthopanax senticosus 10 parts; Blueberry leaf 10 parts; Black trumpet creeper root 10 parts; Wisteria 15 parts; Daphne odora leaf 10 parts; Catalpa 10 parts; Bone-setting herb 15 parts; Lycopodium clavatum 15 parts; Muscle-relaxing herb 15 parts; Clerodendrum trichotomum 15 parts; Chicken blood vine 20 parts; Safflower 15 parts; Eucommia ulmoides 15 parts; Achyranthes bidentata 30 parts; Achyranthes bidentata 30 parts; Curcuma longa 15 parts.

[0007] This invention also provides a method of using the above-mentioned drug formulation for treating rheumatic bone diseases, comprising the following steps: S1. Grind the drugs in the drug formulation into powder to obtain drug powder; S2. Soak the drug powder obtained in step S1 in alcohol to obtain medicinal wine.

[0008] S3. Apply the medicinal wine obtained in step S2 to the affected area.

[0009] Furthermore, in step S2, when the drug powder is soaked in alcohol, the weight ratio of the drug powder to the alcohol is 1:2.

[0010] Furthermore, in step S2, the drug powder is soaked in alcohol for 10 days before use.

[0011] Furthermore, the drug powder is soaked in alcohol for 15 days before use.

[0012] The beneficial effects of this invention are as follows: The drug formula for treating rheumatic bone diseases described in this invention can relieve symptoms such as joint pain, swelling, difficulty in flexion and extension, numbness of limbs, and limited mobility that occur during the recovery period of rheumatoid arthritis, osteoarthritis, and injuries. At the same time, it can improve blood circulation in the affected area, reduce inflammatory response, and relieve soft tissue adhesions, thereby improving the patient's joint function and quality of life.

[0013] Furthermore, it has significant analgesic and anti-swelling effects, a high efficacy rate, and a recurrence rate far lower than existing conventional treatments. It can provide long-term improvement for rheumatic bone diseases, addressing both the symptoms and the root cause.

[0014] Other advantages, objectives, and features of the invention will be set forth in part in the description which follows, and in part will be apparent to those skilled in the art from the following examination, or may be learned from practice of the invention. The objectives and other advantages of the invention can be realized and obtained through the following description. Detailed Implementation

[0015] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Generally, the components of the embodiments of the present invention described and shown herein can be arranged and designed in various different configurations.

[0016] Therefore, the following detailed description of the embodiments of the invention provided in the examples is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0017] It should be noted that similar labels and letters in the following embodiments represent similar items. Therefore, once an item is defined in one embodiment, it does not need to be further defined and explained in subsequent embodiments.

[0018] In the above description of the present invention, it should be noted that the terms "one side," "the other side," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the embodiments, or the orientation or positional relationship commonly used when the product of the invention is in use. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. In addition, the terms "first," "second," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0019] Furthermore, terms such as "identical" do not imply that components must be absolutely identical; minor differences are permissible. The term "perpendicular" simply means that the positional relationship between components is more perpendicular than "parallel," not that the structure must be perfectly perpendicular; a slight tilt is acceptable.

[0020] This invention provides a technical solution: a drug formula for treating rheumatic bone diseases, composed of the following traditional Chinese medicine raw materials in the indicated weight ratios: 5-15 parts of Tianqingdihong; 10-20 parts of Lulutong; 5-15 parts of Taibai Sanqi; 5-15 parts of Moyao; 5-15 parts of Qinghai Fangfeng; 10-20 parts of Bajiaofeng root; 10-20 parts of Meigui root; 10-20 parts of Weilingxian root; 5-15 parts of Duyiwei; 25-35 parts of Jiulixiang root; 10-20 parts of Qianghuo; 10-20 parts of Yanhusuo; 10-20 parts of Baizhi; 10-20 parts of Bawangqi. ; Cinnamomum cassia 5-15 parts; Vine of six directions 25-35 parts; Vine of clear breeze 10-20 parts; Vine of ox 25-35 parts; Cinnamomum camphora 25-35 parts; Gynostemma pentaphyllum 10-20 parts; Vine of large blood vine 10-20 parts; Vine of piercing roots 25-35 parts; Summer pine 10-20 parts; Mulberry branches 15-25 parts; Root of Juglans regia 15-25 parts; Root of Stone-piercing Stone 25-35 parts; Cynanchum paniculatum 5-15 parts; Silkworm excrement 15-25 parts; Osmanthus root 25-35 parts; Willow leaf Antiaris toxicaria 25-35 parts; Mentholatum 10-20 parts; Eclipta prostrata 10-20 parts; Stephania tetrandra 5-15 parts; Achyranthes bidentata root 25-35 parts; Raspberry 10-20 parts; Juniper 10-20 parts; Lijiang Mountain Pseudobulbus Cremastrae 0.4-0.8 parts; Horsetail 5-15 parts; Acanthopanax senticosus 25-35 parts; Uncaria rhynchophylla root 20-30 parts; Acanthopanax senticosus 5-15 parts; Blueberry leaf 5- 15 parts; 5-15 parts of calendula root; 10-20 parts of wisteria root; 5-15 parts of daphne leaf; 5-15 parts of catalpa wood; 10-20 parts of sclerotium root; 10-20 parts of lycopodium; 10-20 parts of clematis root; 10-20 parts of clematis root; 10-20 parts of peony root; 15-25 parts of chicken blood vine; 10-20 parts of safflower; 10-20 parts of eucommia bark; 25-35 parts of oxtail vine; 25-35 parts of flat vine; 10-20 parts of turmeric.

[0021] Tianqingdihong 1, scientific name: Zibei Tiankui, synonym: Poxuedan; The scientific name of Panax notoginseng is *Panax notoginseng var. large-leaved*, and its synonym is *Sweet Panax notoginseng*. The root of the eight-pointed maple is scientifically known as *Rosa rugosa* root, and is also known as *Sanbaicao* root. Rose root scientific name: Rosa rugosa root, synonym: Sanbaicao root; Unique name: Balanunu, Buzi, Dazheheba; Chai Gui (scientific name: Sichuan Cinnamon), also known as San Tiao Jin; Synonyms for Hexagonal Vine: Five-Frugal Vine, Mountain-Broken Claw Vine; Other names for Qingfengteng: Qingteng, Xunfengteng, Guoshanlong; Other names for *Caulis Chaenomeles speciosa*: wild papaya, stone moon, seven sisters vine; Synonyms for Ebony: Ebony, Ebony, White Holly, Black Tiger; Synonyms for *Gnaphalium affine*: ghost hairpin grass, ghost yellow flower, blind intestine grass, flea grass, a handful of needles; Synonyms for *Sargentodoxa cuneata*: *Xuesaitong*; The synonyms of Cipangopaludina chinensis var. flavomarginata are: Spring Root Vine, Wood Gout, Upper Wood Snake; The synonyms of Cudrania tricuspidata root are: Cudrania root, Ground Cotton Root, Pulling Cattle into Rock, Mountain Huangji, Cudrania Vine Root, Iron Fence Root; The synonym of Cynanchum paniculatum is: Other Fairy Trace; The synonyms of Salix brachypoda are: See Blood Fly, Blood Seeing Sorrow, Big Muscle Stretch; The synonyms of Herba Selaginellae are: Golden Silk Grass, Iron Bone Grass, Stop Startled Grass; The synonyms of Vernonia patula are: Clear Sky after Rain, Big Hemp Grass, Pink Grass; The synonyms of Stephania tetrandra are: Stephania for Stephania, Melon Stephania; The synonym of Rubus crataegifolius root is: Tray Root; The synonyms of Rubus corchorifolius are: Hook Along, Raspberry, Mountain Bubble; The synonyms of Iphigenia indica are: Herb Fritillary, Native Fritillary, Dog Disturbing Medicine; The synonyms of Acanthopanax trifoliatus are: White Muscle Root, Spiny Acanthopanax, Three - Armor Skin, Three - Leaf Acanthopanax, Fragrant Vine Thorn; The synonyms of Acanthopanax gracilistylus are: Southern Acanthopanax Bark, Five - Grain Bark; The synonym of Vaccinium vitis - idaea leaf is: Bearberry Leaf; The synonym of Campsis grandiflora root is: Chinese Trumpet Creeper Root; The scientific name of Catalpa ovata is Catalpa ovata, and its synonym is: Thunder and Lightning Wood.

[0022] The pharmacological effects of each component of the drug formula for treating rheumatic bone diseases described in the present invention are as follows: Tianqing Dihong: Pharmacological properties: Sweet and bitter in taste, warm in nature. It belongs to the liver and kidney meridians. It has the effects of dispelling wind and dampness, promoting blood circulation and stopping bleeding, moistening the lungs and relieving cough, etc., and is mainly used to treat rheumatic arthralgia, traumatic injury, and hemiplegia.

[0023] Fructus Liquidambaris: The dried mature fruit inflorescence of Liquidambar formosana. Pharmacological properties: Bitter in taste, neutral in nature. It belongs to the liver and kidney meridians. It has the effects of dispelling wind and activating collaterals, promoting diuresis, and dredging channels.

[0024] Taibai Notoginseng: Pharmacological properties: Sweet and slightly bitter in taste, neutral in nature. It belongs to the liver and spleen meridians; it can dispel wind - dampness, strengthen muscles and bones, promote blood circulation and stop bleeding, and relieve joint swelling and pain, limb numbness.

[0025] Myrrh: Pharmacological properties: Pungent and bitter in taste, neutral in nature. It belongs to the heart, liver, and spleen meridians. It has the effects of promoting blood circulation to stop pain, reducing swelling and promoting granulation.

[0026] Qinghai Saposhnikovia divaricata: Pharmacological properties: Pungent and sweet in taste, slightly warm in nature. It belongs to the bladder, liver, and spleen meridians. Its main effects are dispelling wind and relieving the exterior, eliminating dampness and relieving pain, and stopping convulsions. Clinically, it is commonly used in exterior syndrome of exogenous pathogens, rheumatic arthralgia, and tetanus and other diseases.

[0027] Alangium chinense root: Pharmacological properties: Pungent in taste, warm in nature, toxic; it belongs to the liver and kidney meridians; it dispels wind and dampness, relaxes muscles and activates collaterals, dispels stasis and relieves pain, and is used for rheumatic arthralgia, joint stiffness.

[0028] Rose Root: Medicinal properties: Sweet and slightly bitter in taste, slightly warm in nature. It is mainly used to treat irregular menstruation, leukorrhea, traumatic injury, and rheumatic arthralgia.

[0029] Clematis Root: Medicinal properties: Pungent, salty, and warm in taste. It belongs to the bladder meridian. It has the effects of dispelling wind-dampness, dredging collaterals, relieving pain, and eliminating bone obstruction.

[0030] Lamiophlomis Rotata: Medicinal properties: Sweet and bitter in taste, flat in nature; it belongs to the liver meridian; promoting blood circulation to stop pain, expelling wind and dampness, removing stasis to stop bleeding, and improving rheumatic bone pain and joint strain.

[0031] Murraya Root: Medicinal properties: Pungent and bitter in taste, warm in nature. It belongs to the heart, liver, and lung meridians. Functions and indications: Rheumatic arthralgia, low back pain, traumatic injury, testicular swelling and pain, eczema, and scabies.

[0032] Notopterygium Root: Medicinal properties: Pungent and bitter in taste, warm in nature. It belongs to the bladder and kidney meridians. Its effects are relieving exterior syndrome and expelling cold, dispelling wind and dampness, and relieving pain.

[0033] Corydalis Rhizoma: Medicinal properties: Pungent and bitter in taste, warm in nature. It belongs to the heart, liver, and spleen meridians. Its core effects are promoting blood circulation to activate qi and relieving pain. Angelica Dahurica Root: Medicinal properties: Pungent in taste, warm in nature. It belongs to the lung, stomach, and large intestine meridians. It has the effects of relieving exterior syndrome and expelling cold, dispelling wind and relieving pain, drying dampness to arrest leukorrhea, and dissipating swelling and discharging pus.

[0034] Bergenia Purpurascens: Medicinal properties: Pungent and bitter in taste, slightly cold in nature. It belongs to the liver meridian. Functions and indications: Promoting blood circulation to detoxify, mainly for traumatic injury, swelling and pain due to stasis, abdominal pain, carbuncle and sore toxin, and snake bite.

[0035] Cinnamomum Tamala: Medicinal properties: Pungent and sweet in taste, warm in nature. It belongs to the heart, liver, and kidney meridians. Mainly used to treat cold-damp arthralgia; abdominal pain; dysmenorrhea; traumatic injury.

[0036] Tinospora Hexandra: Medicinal properties: Slightly bitter in taste, cool in nature. It belongs to the kidney and liver meridians. Mainly used to treat rheumatic joint pain, lumbar muscle strain, and traumatic injury.

[0037] Sabia Japonica: Medicinal properties: Bitter in taste, flat in nature. It belongs to the liver and kidney meridians. It has the effects of dispelling wind and dampness, promoting blood circulation and dredging collaterals, and dissipating swelling and relieving pain.

[0038] Tetrastigma: Medicinal properties: Bitter and sour in taste, flat in nature. It belongs to the liver and kidney meridians. Mainly used to treat gynecological stasis, soreness of the waist and knees, stranguria syndrome, and hyperactivity of liver yang and other diseases.

[0039] Tarenna Sinensis: Medicinal properties: Sour, pungent, and slightly bitter in taste. Slightly warm in nature. It belongs to the liver and kidney meridians. Functions and indications: Dispelling wind and reducing swelling, dissipating stasis and relieving pain.

[0040] Setaria Palmifolia: Medicinal properties: Slightly bitter in taste. Warm in nature. It belongs to the liver and kidney meridians. Functions and indications: Traumatic injury, fracture pain, sciatica, trigeminal neuralgia, migraine, supraorbital neuralgia, facial nerve paralysis, lumbar muscle strain and other diseases.

[0041] Sargentodoxa cuneata: Medicinal properties: Bitter taste. Neutral nature. It belongs to the liver and large intestine meridians. Functions and indications: Clearing heat and detoxifying, activating blood circulation and dredging collaterals. It is commonly used to treat rheumatic arthralgia, appendicitis abdominal pain and other symptoms.

[0042] Piper sarmentosum Roxb.: Medicinal properties: Slightly bitter and pungent taste. Cool nature. It belongs to the liver and kidney meridians. Functions and indications: Rheumatic arthralgia.

[0043] Corydalis decumbens (Thunb.) Pers.: Medicinal properties: Pungent and bitter taste. Warm nature. It belongs to the liver, spleen and kidney meridians. Functions and indications: Activating blood circulation, promoting qi movement and relieving pain.

[0044] Mulberry branch: Medicinal properties: Slightly bitter taste. Neutral nature. It belongs to the liver meridian. Functions and indications: Mainly dispelling wind and dampness, dredging collaterals. It is suitable for rheumatic heat arthralgia (such as joint swelling, heat and pain), limb numbness.

[0045] Root of Ficus virens Ait. var. sublanceolata (Miq.) Corner: Medicinal properties: Bitter and astringent taste. Hot nature. It belongs to the liver and kidney meridians. Functions and indications: Dispelling wind, removing dampness, dredging collaterals, detumescence. Treating rheumatic arthralgia, numbness of the limbs, swelling, traumatic injury, scabies and tinea. Root of Cudrania cochinchinensis (Lour.) Kudo & Masam.: Medicinal properties: Light and slightly bitter taste. Mildly cold nature. It belongs to the liver, spleen and kidney meridians. Functions and indications: Dispelling wind and dampness, relieving arthralgia.

[0046] Cynanchum paniculatum (Bunge) Kitagawa: Medicinal properties: Sour and astringent taste. Mildly warm nature. It belongs to the liver and kidney meridians. Functions and indications: Tonifying the liver and kidney, astringing essence and arresting seminal emission.

[0047] Silkworm excrement: Medicinal properties: Sweet and pungent taste. Warm nature. It belongs to the liver, spleen and stomach meridians. Functions and indications: Expelling wind-dampness, regulating the middle and resolving turbidity.

[0048] Root of Osmanthus fragrans Lour.: Medicinal properties: Pungent taste. Mildly warm nature. It belongs to the liver and kidney meridians. Functions and indications: Dispelling cold and breaking stagnation, resolving phlegm and relieving cough, regulating qi and relieving asthma, etc.

[0049] Daphniphyllum oldhamii Hance: Medicinal properties: Pungent taste. Warm nature. It belongs to the liver, spleen and kidney meridians. Functions and indications: Promoting blood circulation to remove stasis, relieving swelling and pain, relaxing muscles and tendons.

[0050] Taenitis blechnoides (Willd.) Barkl.: Medicinal properties: Bitter taste. Warm nature. It belongs to the lung, liver and kidney meridians. Functions and indications: Relieving cough, regulating menstruation, promoting blood circulation, removing dampness, detoxifying and detumescing.

[0051] Inula salicina L.: Medicinal properties: Pungent and bitter taste. Cool nature. It belongs to the kidney and spleen meridians. Functions and indications: Expelling wind and activating collaterals, detoxifying, eliminating accumulation. For rheumatic joint pain, traumatic injury, infantile malnutrition; for external use, treating snake bites.

[0052] Stephania tetrandra S. Moore: Medicinal properties: Very bitter taste. Greatly cold nature. It belongs to the bladder, kidney and spleen meridians. Functions and indications: Spastic pain of hands and feet, rheumatic arthritis.

[0053] Root of Rubus crataegifolius Bunge: Medicinal properties: Sour and sweet taste. Warm nature. It belongs to the kidney and liver meridians. Functions and indications: Kidney deficiency and spermatorrhea, rheumatic arthritis and other symptoms.

[0054] Rubus corchorifolius L. f.: Properties: Bitter and astringent in taste. Neutral in nature. Acting on the liver, kidney, and bladder meridians. Functions and indications: Spitting blood, hematochezia, enteritis, dysentery, rheumatic arthralgia, traumatic injury, irregular menstruation.

[0055] Juniperus rigida Sieb. et Zucc.: Properties: Pungent and sweet in taste. Neutral in nature. Acting on the heart, spleen, liver, stomach, and bladder meridians. Functions and indications: Rheumatic arthralgia and edema caused by dysfunction of the spleen and kidney.

[0056] Iphigenia indica Kunth et Benth.: Properties: Bitter in taste. Cold in nature. Acting on the lung and liver meridians. Functions and indications: Carbuncles, sores, scrofula, rheumatic arthralgia, traumatic stasis pain.

[0057] Equisetum sylvaticum L.: Properties: Sweet and bitter in taste. Neutral in nature. Acting on the heart meridian. Functions and indications: Treating arthralgia, chest pain, dysuria, and dripping pain.

[0058] Acanthopanax trifoliatus (L.) Merr.: Properties: Slightly bitter, pungent, and astringent in taste. Cool in nature. Acting on the lung and kidney meridians. Functions and indications: Clearing heat and detoxifying, expelling wind and removing dampness, relaxing muscles and activating blood circulation.

[0059] Uncaria rhynchophylla Miq. ex Havil. roots: Properties: Bitter and astringent in taste. Cold in nature. Acting on the liver meridian. Functions and indications: Joint gout, hemiplegia, epilepsy, edema, and traumatic injury.

[0060] Acanthopanax gracilistylus W. W. Smith: Properties: Pungent and bitter in taste. Warm in nature. Acting on the liver and kidney meridians. Functions and indications: Expelling wind-dampness, tonifying the liver and kidney, strengthening muscles and bones, promoting diuresis to alleviate edema.

[0061] Vaccinium vitis-idaea L.: Properties: Bitter in taste. Warm in nature. Acting on the kidney and bladder meridians. Functions and indications: Diuretic, detoxifying.

[0062] Campsis grandiflora (Thunb.) Schum. roots: Properties: Sweet and sour in taste. Cold in nature. Acting on the liver, spleen, and kidney meridians. Functions and indications: Cooling blood, expelling wind, promoting blood circulation to remove stasis.

[0063] Wisteria sinensis Sweet roots: Properties: Sweet in taste. Warm in nature. Acting on the heart, liver, and kidney meridians. Functions and indications: Gout, arthralgia.

[0064] Daphne odora Thunb. leaves: Properties: Pungent and bitter in taste. Mildly warm in nature. Acting on the liver and spleen meridians. Functions and indications: Rheumatic arthralgia, traumatic injury.

[0065] Catalpa ovata G. Don wood: Properties: Bitter in taste. Cold in nature. Acting on the lung, liver, and large intestine meridians. Functions and indications: Cholera with no vomiting or diarrhea, hand-foot gout.

[0066] Sambucus chinensis Lindl.: Properties: Pungent and sweet in taste. Neutral in nature. Acting on the liver and kidney meridians. Functions and indications: Treating traumatic stasis pain, fracture and tendon injury, rheumatic arthralgia.

[0067] Lycopodium clavatum L.: Properties: Bitter and pungent in taste. Warm in nature. Acting on the liver, spleen, and kidney meridians. Functions and indications: Expelling wind and dispelling cold, removing dampness and alleviating swelling, relaxing muscles and activating blood circulation.

[0068] Shujincao: Medicinal properties: Pungent and slightly bitter in taste. Warm in nature. It acts on the liver and kidney meridians. Functions and indications: Rheumatic arthralgia; traumatic injury; pain in the muscles and bones; irregular menstruation; cramps in the feet; night blindness; night sweats; rheumatic low back pain; lumbar muscle strain; scalds from fire and water; sores and toxic swelling.

[0069] Choudan: Medicinal properties: Pungent and bitter in taste. Neutral in nature. It acts on the heart, stomach and large intestine meridians. Functions and indications: Clearing heat and detoxifying, promoting blood circulation to remove stasis and reduce swelling, expelling wind and removing dampness, calming the liver and subduing yang.

[0070] Jixueteng: Medicinal properties: Bitter and sweet in taste. Warm in nature. It acts on the liver and kidney meridians. Functions and indications: Rheumatic arthralgia, numbness and paralysis, sallow complexion due to blood deficiency, irregular menstruation.

[0071] Honghua: Medicinal properties: Pungent in taste. Warm in nature. It acts on the heart and liver meridians. Functions and indications: Promoting blood circulation to dredge the channels, dispersing stasis and relieving pain.

[0072] Duzhong: Medicinal properties: Sweet in taste. Warm in nature. It acts on the liver and kidney meridians. Functions and indications: Tonifying the liver and kidney, strengthening the muscles and bones, preventing miscarriage.

[0073] Niumateng: Medicinal properties: Sweet in taste. Warm in nature. It acts on the stomach and liver meridians. Functions and indications: Rheumatic pain, numbness of the limbs, anemia, irregular menstruation.

[0074] Biandanteng: Medicinal properties: Pungent and astringent in taste. Warm in nature. It acts on the liver and spleen meridians. Functions and indications: Rheumatic bone pain, lumbar muscle strain, traumatic injury, hemiplegia.

[0075] Jianghuang: Medicinal properties: Pungent and bitter in taste. Warm in nature. It acts on the liver and spleen meridians. Functions and indications: Pain in the chest and abdomen, pain in the limbs and joints.

[0076] The compatibility relationship of the drug formula for treating rheumatic bone diseases described in the present invention is as follows: King drugs: Niumateng, Biandanteng, Sijiaopi, Niudiedugen, with a relatively heavy dosage, mainly expelling wind and cold, removing dampness and dredging collaterals, promoting blood circulation to remove stasis, directly targeting the core pathogenesis of wind-cold stasis obstruction and meridian blockage in rheumatic bone diseases; Ministerial drugs: Jixueteng, Wujiapi, Duzhong, Shanmei, assisting the king drugs to strengthen the muscles and bones, tonify the liver and kidney, promote qi and activate blood circulation, enhance the effect of dredging collaterals and relieving pain, and taking into account consolidating the root; Assistant drugs: Sheyancao, Ziweigeng, Zitenggen, Choudan, Jiegu Dan, Shenjincao, Shujincao, Ruixiangye, Yuejuye, Lijiangshancigu, Goutenggen, Fangji, Dusong, Honghua, assisting in expelling wind and removing dampness, reducing swelling and relieving pain, relaxing muscles and tendons and dredging collaterals, resolving joint swelling and stiffness, and regulating the properties of the medicine; Guiding drug: Tianqing Dihong, Taibai Sanqi, Chaigui, Zimu, Jianghuang, guiding the drug directly to the focus of the muscles and bones of the joints, regulating the properties of the whole formula, guiding the medicinal power to penetrate the skin and muscle texture, and enhancing the external absorption effect.

[0077] Preferably, the drug formula for treating rheumatic bone diseases described in the present invention is composed of the following traditional Chinese medicine raw materials in the following weight ratios: 10 portions of Tianqingdihong; 15 portions of Lulutong; 10 portions of Taibai Sanqi; 10 portions of Moyao; 10 portions of Qinghai Fangfeng; 15 portions of Bajiaofeng root; 15 portions of Meigui root; 15 portions of Weilingxian root; 10 portions of Duyiwei; 30 portions of Jiulixiang root; 15 portions of Qianghuo; 15 portions of Yanhusuo; 15 portions of Baizhi; 15 portions of Bawangqi; 10 portions of Chai Gui; 30 portions of Liufangteng; 15 portions of Qingfengteng; 30 portions of Niuteng; 30 portions of Wukoushu; 15 portions of Guimaozhen; 15 portions of Daxueteng; 30 portions of Chuangenteng; 15 portions of Xiatianwu; 20 portions of Sangzhi; 20 portions of Huangjueshu root; 30 portions of Chuanposhi root; 10 portions of Xuchangqing; 20 portions of Cansha. ; Osmanthus root 30 parts; Willow leaf antiperspirant 30 parts; Mentholatum 15 parts; Snake eye grass 15 parts; Stephania tetrandra 10 parts; Strychnos nux-vomica root 30 parts; Raspberry 15 parts; Juniper 15 parts; Lijiang mountain wormwood 0.6 parts; Horsetail 10 parts; Acanthopanax senticosus 30 parts; Uncaria rhynchophylla root 25 parts; Acanthopanax senticosus 10 parts; Blueberry leaf 10 parts; Black trumpet creeper root 10 parts; Wisteria 15 parts; Daphne odora leaf 10 parts; Catalpa 10 parts; Bone-setting herb 15 parts; Lycopodium clavatum 15 parts; Muscle-relaxing herb 15 parts; Clerodendrum trichotomum 15 parts; Chicken blood vine 20 parts; Safflower 15 parts; Eucommia ulmoides 15 parts; Achyranthes bidentata 30 parts; Achyranthes bidentata 30 parts; Curcuma longa 15 parts.

[0078] The method of using the above-mentioned drug formula for treating rheumatic bone diseases includes the following steps: S1. Grind the drugs in the drug formulation into powder to obtain drug powder; S2. Soak the medicinal powder obtained in step S1 in alcohol to obtain medicinal wine. The alcohol used to soak the medicinal powder should be 50-60 proof pure grain-brewed high-proof liquor (light aroma / rice aroma type). Alcohol-blended liquor is prohibited. High-proof liquor can fully extract the effective components of the medicinal materials and enhance the penetration and blood-activating effects.

[0079] S3. Apply the medicinal wine obtained in step S2 to the affected area.

[0080] In step S2, when the drug powder is soaked in alcohol, the weight ratio of the drug powder to the alcohol is 1:2.

[0081] In step S2, the medicinal powder is used after being soaked in alcohol for 10 days. Preferably, the medicinal powder is used after being soaked in alcohol for 15 days.

[0082] The drug formula for treating rheumatic bone diseases described in this invention can relieve symptoms such as joint pain, swelling, difficulty in flexion and extension, numbness of limbs, and limited mobility that occur during the recovery period of rheumatoid arthritis, osteoarthritis, and injuries. At the same time, it can improve blood circulation in the affected area, reduce inflammatory response, and relieve soft tissue adhesions, thereby improving the patient's joint function and quality of life.

[0083] Comparative experiment: Eighty patients diagnosed with rheumatic bone disease (joint pain, swelling, and limited mobility) were randomly divided into two groups: a control group and an experimental group, with 40 patients in each group.

[0084] Control group: The treatment was conventional Western medicine plus ordinary external ointment. Specifically, ibuprofen sustained-release capsules were taken orally twice a day, and ordinary rheumatic ointment was applied once a day. Experimental group: The medicinal wine of this invention was applied externally twice a day for 20-30 minutes each time.

[0085] After 30 days of continuous treatment, the efficacy was statistically analyzed. Control group: 12 cases cured, 18 cases effective, 10 cases ineffective, with a total effective rate of 75%; relapse rate after drug withdrawal was 35%. Experimental group: 28 cases were cured (joint pain and swelling completely disappeared, and activity was normal), 10 cases were effective, and 2 cases were ineffective, with a total effective rate of 95%; the recurrence rate was only 5%.

[0086] Therefore, it can be seen that this formula has significant analgesic and anti-swelling effects, high efficacy, and a recurrence rate far lower than existing conventional treatments. It can effectively improve rheumatic bone diseases in the long term, addressing both the symptoms and the root cause.

[0087] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A pharmaceutical formulation for treating rheumatic bone disease, characterized by, Composed of the following Chinese herbal raw materials in the indicated weight ratios: 5-15 parts of Tianqingdihong; 10-20 parts of Lulutong; 5-15 parts of Taibai Sanqi; 5-15 parts of Moyao; 5-15 parts of Qinghai Fangfeng; 10-20 parts of Bajiaofeng root; 10-20 parts of Meigui root; 10-20 parts of Weilingxian root; 5-15 parts of Duyiwei; 25-35 parts of Jiulixiang root; 10-20 parts of Qianghuo; 10-20 parts of Yanhusuo; 10-20 parts of Baizhi; 10-20 parts of Bawangqi. ; Cinnamomum cassia 5-15 parts; Vine of six directions 25-35 parts; Vine of clear breeze 10-20 parts; Vine of ox 25-35 parts; Cinnamomum camphora 25-35 parts; Gynostemma pentaphyllum 10-20 parts; Vine of large blood vine 10-20 parts; Vine of piercing roots 25-35 parts; Summer pine 10-20 parts; Mulberry branches 15-25 parts; Root of Juglans regia 15-25 parts; Root of Stone-piercing Stone 25-35 parts; Cynanchum paniculatum 5-15 parts; Silkworm excrement 15-25 parts; Osmanthus root 25-35 parts; Willow leaf Antiaris toxicaria 25-35 parts; Mentholatum 10-20 parts; Eclipta prostrata 10-20 parts; Stephania tetrandra 5-15 parts; Achyranthes bidentata root 25-35 parts; Raspberry 10-20 parts; Juniper 10-20 parts; Lijiang Mountain Pseudobulbus Cremastrae 0.4-0.8 parts; Horsetail 5-15 parts; Acanthopanax senticosus 25-35 parts; Uncaria rhynchophylla root 20-30 parts; Acanthopanax senticosus 5-15 parts; Blueberry leaf 5- 15 parts; 5-15 parts of calendula root; 10-20 parts of wisteria root; 5-15 parts of daphne leaf; 5-15 parts of catalpa wood; 10-20 parts of sclerotium root; 10-20 parts of lycopodium; 10-20 parts of clematis root; 10-20 parts of clematis root; 10-20 parts of peony root; 15-25 parts of chicken blood vine; 10-20 parts of safflower; 10-20 parts of eucommia bark; 25-35 parts of oxtail vine; 25-35 parts of flat vine; 10-20 parts of turmeric.

2. The pharmaceutical formulation for treating rheumatic diseases according to claim 1, wherein Composed of the following Chinese herbal raw materials in the indicated weight ratios: 10 portions of Tianqingdihong; 15 portions of Lulutong; 10 portions of Taibai Sanqi; 10 portions of Moyao; 10 portions of Qinghai Fangfeng; 15 portions of Bajiaofeng root; 15 portions of Meigui root; 15 portions of Weilingxian root; 10 portions of Duyiwei; 30 portions of Jiulixiang root; 15 portions of Qianghuo; 15 portions of Yanhusuo; 15 portions of Baizhi; 15 portions of Bawangqi; 10 portions of Chai Gui; 30 portions of Liufangteng; 15 portions of Qingfengteng; 30 portions of Niuteng; 30 portions of Wukoushu; 15 portions of Guimaozhen; 15 portions of Daxueteng; 30 portions of Chuangenteng; 15 portions of Xiatianwu; 20 portions of Sangzhi; 20 portions of Huangjueshu root; 30 portions of Chuanposhi root; 10 portions of Xuchangqing; 20 portions of Cansha. ; Osmanthus root 30 parts; Willow leaf antiperspirant 30 parts; Mentholatum 15 parts; Snake eye grass 15 parts; Stephania tetrandra 10 parts; Strychnos nux-vomica root 30 parts; Raspberry 15 parts; Juniper 15 parts; Lijiang mountain wormwood 0.6 parts; Horsetail 10 parts; Acanthopanax senticosus 30 parts; Uncaria rhynchophylla root 25 parts; Acanthopanax senticosus 10 parts; Blueberry leaf 10 parts; Black trumpet creeper root 10 parts; Wisteria 15 parts; Daphne odora leaf 10 parts; Catalpa 10 parts; Bone-setting herb 15 parts; Lycopodium clavatum 15 parts; Muscle-relaxing herb 15 parts; Clerodendrum trichotomum 15 parts; Chicken blood vine 20 parts; Safflower 15 parts; Eucommia ulmoides 15 parts; Achyranthes bidentata 30 parts; Achyranthes bidentata 30 parts; Curcuma longa 15 parts.

3. A method of using a pharmaceutical formulation for the treatment of rheumatic bone diseases according to claim 1 or 2, characterized in that, Includes the following steps: S1. Grind the drugs in the drug formulation into powder to obtain drug powder; S2. Soak the drug powder obtained in step S1 in alcohol to obtain medicinal wine; S3. Apply the medicinal wine obtained in step S2 to the affected area.

4. The method of using the drug formulation for treating rheumatic bone diseases according to claim 3, characterized in that: In step S2, when the drug powder is soaked in alcohol, the weight ratio of the drug powder to the alcohol is 1:

2.

5. The method of using a pharmaceutical formulation for the treatment of a rheumatic disorder according to claim 3, wherein: In step S2, the drug powder is soaked in alcohol for 10 days before it is used.

6. The method of using a pharmaceutical formulation for the treatment of a rheumatic disorder according to claim 5, wherein: The medicine powder is soaked in alcohol for 15 days before use.