A positive hydrogen pressure hydrogen partial pressure positive hydrogen increase latching method for hydrogen-containing liquid

Abstract

This invention belongs to the field of hydrogen-containing liquid packaging, storage, and preservation technology, and specifically relates to a method for positive hydrogen partial pressure hydrogen enhancement and locking in hydrogen-containing liquids. This invention completely overcomes the industry pain point of high-concentration long-term preservation of hydrogen-containing liquids, achieving positive hydrogen enhancement without breaking the original sealed bottle, and increasing the concentration over time, filling the global gap in long-term hydrogen preparation locking technology. This invention provides a soft and hard dual-structure hydrogen locking solution suitable for industrial mass production and long-distance safe storage and transportation, promoting the compliant, low-cost, and large-scale circulation of high-concentration hydrogen preparations, and enabling the full-body broad-spectrum antioxidant technology of hydrogen molecules to be truly applied in clinical practice, benefiting public health.

Description

Technical Field

[0001] This invention relates to the field of hydrogen-containing liquid packaging, storage, and preservation technology, specifically to a positive hydrogen-enriching storage packaging system based on a micro-positive pressure hydrogen partial pressure gradient, which allows for external permeation without breaking the original bottle seal and results in a higher concentration over time. This system is suitable for long-term hydrogen-locking and hydrogen-enriching storage of medical hydrogen saline, hydrogen glucose injection, pharmaceutical solvents, hydrogen-rich drinking water, hydrogen-based traditional Chinese medicine solutions, and various sealed bottled liquids. It belongs to the fields of medical device packaging, functional liquid preservation, and hydrogen molecule biomedical applications. Background Technology

[0002] Hydrogen molecule medicine has undergone nearly two decades of global systematic research and has now formed a complete system of basic theory and clinical application. With its core biological effects such as highly selective scavenging of toxic free radicals, potent anti-inflammatory effects, antioxidant activity, and regulation of cell signaling pathways, hydrogen molecules are recognized by the global medical community as safe and broad-spectrum physiological antioxidants. Extensive animal experiments and human clinical trials have validated that hydrogen molecules have demonstrated clear interventional effects in multiple disease areas: they can be used for tumor prevention and adjuvant intervention, inhibiting tumor-related oxidative stress responses and reducing the activity of tumor-inducing factors; they have a regulatory effect on metabolic syndromes such as hypertension, hyperlipidemia, hyperglycemia, and fatty liver; they can improve neurological damage such as cerebral infarction and neurodegenerative diseases; they can intervene in respiratory problems such as chronic lung inflammation and pulmonary fibrosis; they can repair gastric mucosa and improve intestinal inflammation; they can reduce vascular endothelial damage and improve cardiovascular microcirculation; and they can also regulate immunity and delay aging.

[0003] Currently, the global application of hydrogen preparations is mainly divided into two major technical routes: one is targeted local hydrogen release technology, which intervenes only at a single point on the lesion site, resulting in narrow application scenarios and a limited number of beneficiaries; the other is the systemic intervention route, which uses methods such as drinking hydrogen-rich water or intravenous infusion of hydrogen saline to allow hydrogen molecules to circulate in the bloodstream and broadly eliminate harmful free radicals throughout the body, achieving overall antioxidant, anti-inflammatory, and anti-cancer and anti-aging effects. However, this route has long faced industry bottlenecks such as difficulties in preparing high concentrations, difficulties in long-term stable storage, and rapid concentration decay during storage and transportation. This has prevented the large-scale production and distribution of high-concentration hydrogen preparations, hindering the realization of the enormous medical value of the broad-spectrum application of hydrogen molecules throughout the body, becoming a core pain point that has plagued the global hydrogen medicine industry for decades.

[0004] Existing hydrogen-rich liquid products generally suffer from industry pain points such as continuous hydrogen concentration decay, short shelf life, and inability to maintain quality for extended periods. Currently, the mainstream packaging technology for hydrogen-rich water and hydrogen saline solution on the market adopts a passive hydrogen-locking logic of "filling and dissolving hydrogen and then sealing to lock in hydrogen": hydrogen is dissolved once during production, and it continuously escapes and decays throughout the subsequent storage process, without any concentration recovery mechanism.

[0005] The existing packaging has the following technical defects: 1. Ordinary PET plastic bottles have poor hydrogen barrier properties, allowing hydrogen molecules to quickly penetrate the bottle wall and dissipate, with the concentration approaching zero within a few days; 2. Conventional aluminum foil bags are mostly three-layer structures with limited barrier properties, and their barrier properties still show significant degradation after long-term storage; conventional four-layer film structures on the market generally place the aluminum foil layer on the outermost layer, which is easily damaged by friction during long-distance transportation, resulting in barrier failure. 3. Common hydrogen-locking methods in the industry are nitrogen filling, inert gas isolation, and vacuum isolation, which can only delay escape and cannot increase hydrogen production; 4. Existing technology cannot perform secondary hydrogen replenishment or long-term hydrogen enhancement on original finished products that have already left the factory, are sealed, and are not broken. 5. The enclosed pure hydrogen space poses safety hazards, lacks pressure relief protection structure, and is not suitable for large-scale distribution and sales.

[0006] In summary, existing technologies are all passive hydrogen locking and continuous decay, lacking a positive hydrogen locking and enrichment system that can achieve long-term stability, controllable decay, active hydrogen permeation, adaptability to industrial storage and transportation, and safety and controllability. This seriously restricts hydrogen medicine from moving from the laboratory to large-scale clinical application and the public health market. Summary of the Invention

[0007] This invention provides a method for positive hydrogen partial pressure increase and hydrogen latching of hydrogen-containing liquids under micro-positive pressure, which can solve the problems pointed out in the background art.

[0008] A method for hydrogen-containing liquid micro-positive pressure hydrogen partial pressure positive increase hydrogen latching includes the following steps: Step 1: Select original, unopenable hydrogen-containing liquid finished products Step 2: Place the entire unit externally without breaking the seal into the hydrogen-locking container. The selected hydrogen-containing liquid product is placed entirely into a sealed hydrogen-locking container; Step 3: Initial sealing and shaping The hydrogen lock container is pre-sealed, with a vacuuming interface and a gas filling interface provided. Step 4: Deep negative pressure impurity removal The hydrogen lock container is vacuumed under negative pressure through the vacuum port to completely remove air, water vapor and residual impurities from the inside of the hydrogen lock container, ensuring the purity of the hydrogen partial pressure in the subsequent process. Step 5: Establish a high-purity hydrogen environment with a slight positive pressure of 0.03MPa-0.08MPa. Medical-grade high-purity hydrogen is introduced into the hydrogen-locking container to establish a stable hydrogen partial pressure environment with a slight positive pressure of 0.03MPa-0.08MPa, thus completing the final complete sealing. Preferably, the hydrogen lock container is equipped with a two-way filling and releasing safety valve; when establishing a high-purity hydrogen environment, the two-way filling and releasing safety valve serves as the filling interface; when used by the end user, it serves as a pressure relief safety valve for pressure relief.

[0009] Preferably, the hydrogen-locking container is a soft-bag hydrogen-locking container or a rigid hydrogen-locking device.

[0010] Preferably, the soft-bag hydrogen-locking container is a high-barrier composite membrane.

[0011] Preferably, the high-barrier composite film consists of, from the inside out, a PE heat-sealing layer, an NY nylon reinforcing layer, an AL aluminum foil hydrogen barrier layer, and a PET outer layer.

[0012] Preferably, the outer side of the high-barrier composite film is entirely covered or covered with a high-strength, wear-resistant polymer protective film.

[0013] Preferably, the rigid hydrogen-locking device includes a rigid housing with an opening through which the hydrogen-containing liquid product can be placed, and is equipped with a sealing cap for sealing.

[0014] Preferably, the rigid hydrogen-locking device is made of ABS, stainless steel, or fiberglass, and its inner wall is coated with a high hydrogen-barrier polymer coating.

[0015] This invention provides a method for positive hydrogen partial pressure increase and hydrogen latching of hydrogen-containing liquids under micro-positive pressure, which has the following beneficial effects: 1. Completely overcome the industry pain point of high-concentration long-term preservation of hydrogen-containing liquids, achieve positive hydrogen addition without breaking the original sealed bottle, and increase the concentration over time, filling the global gap in long-term hydrogen preparation technology; 2. Provide a dual-structure hydrogen locking solution with both soft and hard components, suitable for industrial mass production and safe long-distance storage and transportation, to promote the compliant, low-cost, and large-scale circulation of high-concentration hydrogen preparations, and to truly bring the broad-spectrum antioxidant technology of hydrogen molecules to clinical practice, benefiting public health. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the high-barrier composite membrane of Embodiment 1 of the present invention. Figure 2 This is a schematic diagram of the hard hydrogen-locking device according to Embodiment 2 of the present invention. Explanation of reference numerals in the attached figures: Numbers in the diagram: PE heat-sealing layer 11; NY nylon reinforcing layer 12; AL aluminum foil hydrogen barrier layer 13; PET outer layer 14; high-strength wear-resistant polymer protective film 15; inflation / deflation valve interface 16; rigid shell 21; sealing cap 22; two-way inflation / deflation safety valve 23. Detailed Implementation

[0017] The following detailed description of a specific embodiment of the present invention is provided in conjunction with the accompanying drawings. However, it should be understood that the scope of protection of the present invention is not limited to the specific embodiment.

[0018] like Figure 1-2As shown in the figure, an embodiment of the present invention provides a method for positive hydrogen partial pressure increase and hydrogen latching of hydrogen-containing liquids, comprising the following steps: Example 1:

[0019] Step 1: Select original, unopenable hydrogen-containing liquid finished products Hydrogen-containing liquid products can include various hydrogen-containing liquid products such as hydrogen-rich saline, hydrogen-rich glucose injection, hydrogen-rich purified water, hydrogen-rich drinking water, hydrogen-rich traditional Chinese medicine liquid, and hydrogen-rich medical solvent; this invention can select bottled hydrogen-rich drinking water. Step 2: Place the entire unit externally without breaking the seal into the hydrogen-locking container. The selected bottled hydrogen-rich drinking water is placed entirely into a sealed hydrogen-locking container. The hydrogen-locking container is a soft bag hydrogen-locking container, specifically a high-barrier composite film. The high-barrier composite film consists of, from the inside out, a PE heat-sealing layer 11, an NY nylon reinforcing layer 12, an AL aluminum foil hydrogen-blocking layer 13, and a PET outer layer 14. The NY nylon reinforcing layer 12 has excellent puncture resistance and abrasion resistance, and can resist the shaking and friction impact of the bottle inside the bag. The AL aluminum foil hydrogen-blocking layer 13 is completely protected by the two side film layers and is not easily damaged. The outer side of the high-barrier composite film is completely covered or covered with a high-strength wear-resistant polymer protective film 15 for long-distance transportation of the whole vehicle, multi-layer stacking, and handling friction protection.

[0020] Step 3: Initial sealing and shaping The high-barrier composite film is pre-sealed by a sealing machine, with a vacuum interface and an inflation interface reserved. The vacuum interface and the inflation interface can be an inflation / deflation valve interface 16. Step 4: Deep negative pressure impurity removal The high-barrier composite membrane is vacuumed under negative pressure through the vacuum port to completely remove air, water vapor and residual impurities from inside the high-barrier composite membrane, ensuring the purity of subsequent hydrogen partial pressure. Step 5: Establish a high-purity hydrogen environment with a slight positive pressure of 0.03MPa-0.08MPa. Medical-grade 99.99% high-purity hydrogen is introduced into the high-barrier composite membrane to establish a stable hydrogen partial pressure environment with a slight positive pressure of 0.03MPa-0.08MPa, thus achieving final complete sealing. Example 2:

[0021] Step 1: Select original, unopenable hydrogen-containing liquid finished products Hydrogen-containing liquid products can include various hydrogen-containing liquid products such as hydrogen-rich saline, hydrogen-rich glucose injection, hydrogen-rich purified water, hydrogen-rich drinking water, hydrogen-rich traditional Chinese medicine liquid, and hydrogen-rich medical solvent; this invention can select bottled hydrogen-rich drinking water. Step 2: Place the entire unit externally without breaking the seal into the hydrogen-locking container. The selected bottled hydrogen-rich drinking water product is placed entirely into a sealed hydrogen-locking container. The hydrogen-locking container is a rigid hydrogen-locking device, which includes a rigid shell 21 with an opening through which the hydrogen-containing liquid product can be placed. A sealing cap 22 is provided for sealing, and the connection is sealed with a sealing strip or sealing gasket. The rigid hydrogen-locking device is made of ABS, stainless steel, or fiberglass, and its inner wall is coated with a high hydrogen-barrier polymer coating.

[0022] The rigid hydrogen-locking device is highly rigid, drop-resistant, compression-resistant, and can withstand the bumps of long-distance logistics. It is suitable for high-end medical use, premium gift boxes, and high-value medical preparations. It also relies on constant hydrogen partial pressure to achieve a positive hydrogen enrichment effect where the hydrogen concentration increases the longer the storage time.

[0023] Step 3: Initial sealing and shaping The rigid hydrogen-locking device is pre-sealed by the sealing cap 22, and a vacuum interface and a gas filling interface are reserved. The vacuum interface and the gas filling interface can be a two-way gas filling and venting safety valve 23. Step 4: Deep negative pressure impurity removal The hard hydrogen-locking device is vacuumed under negative pressure through the vacuum port to completely remove air, water vapor and residual impurities from inside the device, ensuring the purity of the subsequent hydrogen partial pressure. Step 5: Establish a high-purity hydrogen environment with a slight positive pressure of 0.03MPa-0.08MPa. Medical-grade 99.99% high-purity hydrogen is introduced into the rigid hydrogen-locking device to establish a stable hydrogen partial pressure environment with a slight positive pressure of 0.03MPa-0.08MPa, thus completing the final complete sealing. Specifically, the rigid hydrogen locking device is equipped with a two-way filling and releasing safety valve 23; when establishing a high-purity hydrogen environment, the two-way filling and releasing safety valve 23 serves as the filling interface; when used by end users, it serves as a pressure relief safety valve for pressure relief, and can also serve as a vacuum interface.

[0024] The above-disclosed embodiments are merely a few specific examples of the present invention. However, the embodiments of the present invention are not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A method for hydrogen-containing liquid micro-positive pressure hydrogen partial pressure positive increase hydrogen latching, characterized in that: Includes the following steps: Step 1: Select original, unopenable hydrogen-containing liquid finished products Step 2: Place the entire unit externally, without breaking the seal, into the hydrogen-locking container. The selected hydrogen-containing liquid product is placed entirely into a sealed hydrogen-locking container. Step 3: Initial sealing and shaping The hydrogen lock container is pre-sealed, with a vacuuming interface and a gas filling interface provided. Step 4: Deep negative pressure impurity removal The hydrogen lock container is vacuumed under negative pressure through the vacuum port to completely remove air, water vapor and residual impurities from the inside of the hydrogen lock container, ensuring the purity of the hydrogen partial pressure in the subsequent process. Step 5: Establish a high-purity hydrogen environment with a slight positive pressure of 0.03MPa-0.08MPa. Medical-grade high-purity hydrogen is introduced into the hydrogen-locking container to establish a stable hydrogen partial pressure environment with a slight positive pressure of 0.03MPa-0.08MPa, thus completing the final complete sealing. According to claim 1, the method for positive hydrogen partial pressure hydrogen storage of hydrogen-containing liquid under micro-positive pressure is characterized in that: the hydrogen storage container is equipped with a two-way filling and releasing safety valve (23); when establishing a high-purity hydrogen environment, the two-way filling and releasing safety valve (23) serves as the filling interface; when used by the end user, it serves as a pressure relief safety valve for pressure relief.

2. The method of claim 1, wherein the hydrogen-containing liquid micro-positive pressure hydrogen partial pressure positive hydrogen increase latching method is characterized by: The hydrogen-locking container is either a soft-bag hydrogen-locking container or a rigid hydrogen-locking device.

3. The method for positive hydrogen partial pressure increase and hydrogen latching of hydrogen-containing liquids under micro-positive pressure according to claim 3, characterized in that: The soft-bag hydrogen-locking container is a high-barrier composite membrane.

4. The method for positive hydrogen partial pressure increase and hydrogen latching of hydrogen-containing liquids under micro-positive pressure according to claim 4, characterized in that: The high-barrier composite film consists of, from the inside out, a PE heat-sealing layer (11), an NY nylon reinforcing layer (12), an AL aluminum foil hydrogen barrier layer (13), and a PET outer layer (14).

5. The positive hydrogen partial pressure forward hydrogen gain latching method of claim 5, wherein: The high-barrier composite membrane is entirely covered or covered with a high-strength wear-resistant polymer protective film (15).

6. The method of claim 3, wherein the hydrogen containing liquid micro-positive hydrogen partial pressure positive hydrogen increase latching method is characterized by: The rigid hydrogen-locking device includes a rigid housing (21) with an opening through which hydrogen-containing liquid products can be placed and is sealed with a sealing cap (22).

7. The method for positive hydrogen partial pressure increase and hydrogen latching of hydrogen-containing liquids under micro-positive pressure according to claim 7, characterized in that: The rigid hydrogen-locking device is made of ABS, stainless steel or fiberglass, and its inner wall is coated with a high hydrogen-barrier polymer coating.

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