Liquid personal care composition with improved skin benefits

Abstract

The present invention provides a liquid personal care composition comprising 0.1 to 40 wt% of a non-soap surfactant; 0.01 to 10 wt% of a rheology modifier; 0.0001 wt% to 5 wt% of a PPAR activator; 0.01 to 4 wt% of a starch-containing complex carbohydrate; and 5 to 80 wt% of water, wherein the PPAR activator is 10-hydroxystearic acid or 12-hydroxystearic acid or a combination thereof, and wherein the starch is in an ungelatinized form in the composition.

Description

Technical Field

[0001] This invention relates to cosmetic compositions designed to improve skin appearance and health. Specifically, it relates to the field of cleansing compositions that provide skin with benefits such as even skin tone, radiance, clarity, and barrier function. More particularly, this invention relates to such compositions containing complex carbohydrates (including starch) and PPAR activators. Background Technology

[0002] Skin degenerates due to skin conditions, environmental damage (wind, air conditioning, central heating), or through the normal aging process (chronoaging), which can be accelerated by sun exposure (photoaging). In recent years, the demand for cosmetic compositions and beauty methods to improve the appearance and condition of the skin has increased significantly.

[0003] Many people are concerned about their skin quality and appearance and want to work on it. Dermatologists also want to ensure that cleansing products support the skin and help improve its quality. Essentially, cleansing products should care for the skin and be applied back to it.

[0004] Peroxisome proliferator-activated receptor (PPAR) is a transcription factor that controls lipid metabolism. Three isoforms exist: PPARα, PPARβ / δ, and PPARγ, all located in the skin, according to Riviers et al., J. Invest. Dermatol. 111, 1116-1121 (1998). A series of specific fatty acids activate these factors, resulting in anti-inflammatory effects that reduce skin irritation and normalize skin metabolism by promoting differentiation / anti-proliferation responses, thus providing additional skin care benefits. In US-A-5981586, Pershadsingh taught that PPAR ligands can reduce proliferation and inflammation in the skin. In PCT application WO-A-98 / 32444, Elias et al. taught that PPAR ligands can restore / prevent skin barrier dysfunction. In EP-A-888773, Malnoe et al. described the use of PPAR-activated lipid phellandrene in the treatment and prevention of inflammation in superficial tissues. Furthermore, in PCT application WO-A-99 / 47110, Alaluf et al. taught the use of petropicrin or its glycerides in reducing skin irritation in skin treatments aimed at simultaneously combating aging and wrinkles, and also provided skin-whitening properties. In EP-A-709084, Laugier et al. described the use of coriander oil rich in petropicrin in skin cosmetic compositions for moisturizing dry skin. In US-A-5260053, Chappell et al. described a deodorant formulation specifically containing coriander oil that achieves odor reduction and masks any residual androsterone compounds by reducing the populations of both micrococci and diphtheria-like bacteria.

[0005] WO2018113636 (Unilever) discloses a combination of modified GSH module amino acid mixtures containing cystine, glutamic acid and glycine with PPAR-activated fatty acids, which achieves a synergistic increase in skin whitening, thereby offsetting the disadvantage of low solubility of cystine.

[0006] WO2001008653 (Unilever) discloses a topical composition comprising: (a) a first lipid selected from phellandic acid and / or docosahexaenoic acid and / or derivatives thereof; (b) a second lipid being an activator of peroxisome proliferator-activated receptor alpha subtype and / or derivatives thereof and / or mixtures thereof; and (c) a skin-acceptable mediator; provided that the first and second lipids are not the same lipids. This composition can be used as a cosmetic anti-aging skin cream and skin lotion.

[0007] WO12110276 (Unilever) discloses a leave-on, non-solid oil continuous skin conditioning composition containing 12-hydroxystearic acid. The composition contains 12HSA but still has a relatively low viscosity, making it suitable for spreading on the skin, and is stable during storage and structurally reversible through temperature cycling.

[0008] WO24002647 relates to a detergent composition with a stable composition. This detergent composition comprises a mixture of a biodegradable thickener and an unsaturated zwitterionic surfactant. The detergent composition has a stable viscosity and, surprisingly, exhibits no shrinkage, discoloration, or odor even after storage at high temperatures.

[0009] Hydroxystearic acid has been known in the cosmetics industry for some time. However, complex carbohydrates such as starch have been used as part of the structuring system in soap bars, but no specific benefits have been reported, and they are mainly used as fillers.

[0010] Most people consider skin health and appearance to be one of the key indicators of their own beauty and well-being. This is influenced by factors such as age, hormonal changes, the occurrence of acne, and exposure to sunlight and pollution.

[0011] Therefore, there is always a need for a composition that can improve the appearance of the skin, and it is highly desirable for consumers to include skin-beneficial agents in consumer products that are already part of their daily cleansing routine and do not require any additional skin care steps.

[0012] Therefore, cleansing compositions that meet the immediate need for skin improvement need to be available in an affordable manner and work to enhance the skin with continued use. Summary of the Invention

[0013] According to a first aspect, the present invention discloses a liquid personal care composition comprising: A first aspect of the present invention provides a liquid cleaning composition comprising: i. 0.1 to 40% by weight of non-soap surfactants; ii. 0.01 to 10% by weight of rheology modifier; iii. 0.0001% to 5% by weight of PPAR activator; iv. 0.01 to 20% by weight of starchy complex carbohydrates; and v. 5 to 80% by weight of water.

[0014] A second aspect of the present invention provides a method for preparing a liquid personal care composition according to the first aspect, the method comprising the steps of: a. Dissolving non-soap surfactants and dispersing rheology modifiers in water to form an aqueous medium; b. Adding a starch-containing complex carbohydrate to the aqueous medium of step (a) to obtain the liquid cleaning composition of the first aspect; PPAR activator is added during step (a) or (b).

[0015] A third aspect of the invention provides the use of PPAR activator and starch-containing complex carbohydrate in a liquid cleansing composition according to the first aspect for providing shine to the skin compared to a liquid cleansing composition not containing PPAR activator and starch-containing complex carbohydrate.

[0016] A fourth aspect of the invention provides the use of PPAR activator and starch-containing complex carbohydrate in a liquid cleansing composition according to the first aspect for providing an even skin tone compared to a liquid cleansing composition not containing PPAR activator and starch-containing complex carbohydrate.

[0017] The fifth aspect of the invention provides the use of PPAR activator and starch-containing complex carbohydrate in a liquid cleansing composition according to the first aspect for providing skin clarity compared to a liquid cleansing composition not containing PPAR activator and starch-containing complex carbohydrate.

[0018] The sixth aspect of the invention provides the use of PPAR activator and starch-containing complex carbohydrate in a liquid cleansing composition according to the first aspect for fading skin spots compared to a liquid cleansing composition not containing PPAR activator and starch-containing complex carbohydrate.

[0019] These and other aspects, features, and advantages will become apparent to those skilled in the art from the following detailed description and appended claims. For the avoidance of doubt, any feature of one aspect of the invention may be used in any other aspect of the invention.

[0020] The term "comprising" does not imply limitation to any element subsequently stated, but rather includes unspecified elements of primary or secondary functional importance. In other words, the listed steps, elements, or options need not be exhaustive. Whenever the terms "comprising" or "having" are used, these terms mean equivalent to "comprising" as defined above. In other words, the listed steps or options need not be exhaustive. It should be noted that the examples given in the following description are intended to illustrate the invention and not to limit the invention to those examples alone. Similarly, unless otherwise stated, all percentages are by weight / weight percentage.

[0021] Except as expressly stated in the operational and comparative examples or elsewhere, all figures in this specification and claims indicating the amount or reaction conditions of the material, the physical properties of the material, and / or the use thereof should be understood to be modified by the word “about”.

[0022] Numerical ranges expressed in the format "x to y" are understood to include both x and y. When multiple preferred ranges for a particular feature are described in the format "x to y", it is understood that combinations of all ranges with different endpoints can also be considered.

[0023] It should be noted that when specifying any concentration or amount range, any particular upper limit concentration can be associated with any particular lower limit concentration or amount.

[0024] To gain a more complete understanding of the above and other features and advantages of the present invention, reference should be made to the following detailed description of preferred embodiments. Detailed Implementation

[0025] This invention relates to aqueous skin cleansing compositions suitable for topical application to clean the human body (e.g., skin and hair). More particularly, it relates to liquid compositions that provide improved skin benefits.

[0026] PPAR activators have been known in the cosmetics industry for some time. However, starch-containing complex carbohydrates have been used as part of structured systems in soap bars, but no specific benefits have been reported; they are mainly used as fillers.

[0027] The inventors were surprised to discover that the compositions produce beneficial skin properties when the ingredients function in a given weight percentage range. The level of skin benefits obtained from the combination of these ingredients (as measured by relevant methods) is higher than that obtained from using any one of them alone, and in fact, complex carbohydrates such as starch were previously unknown for these benefits. The introduction of starch-containing complex carbohydrates into liquid shower gel formulations has shown unexpected benefits. These unexpected benefits extend to areas of skin improvement such as barrier health, hydration, and skin tone. Complex carbohydrates such as starch also synergize with other formulation components to further improve parameters, ultimately leading to a higher level of skin care benefits. Surprisingly, starch-containing complex carbohydrates in liquids, as a renewable and safe alternative to natural sources of siloxanes and other polymers, contribute to improved skin feel, better foaming, and a better final state sensory experience.

[0028] When evaluating the skin benefits of the combination of PPAR activators and starch-containing complex carbohydrates, such as radiance, skin clarity, and even skin tone, the results of the compositions of the present invention showed synergistic beneficial effects. It was also found that the compositions of the present invention are gentle, mild, smooth, and soft. This is also an advantageous aspect of the invention, namely, that a cleansing composition, as part of everyone's basic daily hygiene routine, can perform such functions to improve skin tone, skin clarity, fading of blemishes, and skin radiance. The inventors of the present invention have found with great surprise that a composition, as part of everyone's daily routine, can target and resolve these skin problems without any specific composition such as serums, creams, etc. Therefore, the inventors have been able to realize a formulation that can address many skin problems at once without any additional effort.

[0029] Liquid personal care composition The present invention provides a liquid personal care composition comprising: 0.1 to 40 wt% of a non-soap surfactant; 0.01 to 10 wt% of a rheology modifier; 0.0001 wt% to 5 wt% of a PPAR activator; 0.01 to 20 wt% of a starch-containing complex carbohydrate; and 5 to 80 wt% of water.

[0030] The compositions of the present invention provide improved benefits to the skin, such as radiance, skin clarity and even skin tone, and are gentler and leave the skin feeling soft after use.

[0031] PPAR activator Peroxisome proliferator-activated receptor (PPAR) is a transcription factor that controls lipid metabolism. Three isoforms exist: PPARα, PPARβ / δ, and PPARγ, all located in the skin.

[0032] The preferred PPAR activators are PPAR fatty acids such as cis-parinaric acid, cis-9-trans-11 conjugated linoleic acid, columbinic acid, docosahexaenoic acid, eicosapentaenoic acid, hexadecanetrienoic acid, trans-linolenic acid (an isomer of linolenic acid), phellandrene, pinolenic acid, pine nut oil acid, pomegranate acid, ricinoleic acid, trans-ricinoleic acid (an isomer of ricinoleic acid), octadecanoic acid, trans-10-cis-12 conjugated linoleic acid, 7-trans-octadecanoic acid, and trans-isooleic acid.

[0033] Potential sources of hydrolyzable PPAR precursors include triglycerides such as coriander seed oil for apigenic acid, balsam seed oil, parinarium laurinarium kernel oil, or sabastiana brasilinensis seed oil for cis-perilla acid, dehydrated castor seed oil for conjugated linoleic acid, and columbine (aquilegia vulgaris) oil for gulombinic acid.

[0034] Ideally, PPAR acids contain 16 or 18 carbon atoms. Most preferred PPAR acids are olefinically unsaturated, and particularly preferred are monounsaturated, diunsaturated, or triunsaturated. Many of the most desirable PPAR-activating acids are not only unsaturated but also C16 or C18 acids. Optional PPAR acids (xvii) include 12-hydroxystearic acid, sometimes abbreviated as 12-HSA, which is effective for the purposes of this invention at concentrations below those required to form gelling agents.

[0035] Compared to the same composition lacking PPAR ligands, the proportion of fatty acid PPAR ligands in this invention is at least the minimum proportion that exhibits reduced irritation and / or improved skin condition. As anticipated, such a minimum proportion varies not only with the compound but also depends on whether the acid is used in free form or introduced via its precursor. This minimum proportion can be determined by the patch testing method described later herein.

[0036] Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors known to have three subtypes: α, β, and γ, with different tissue distributions. The α subtype of PPARs (hereinafter referred to as PPARα) is present in the skin. Preferred PPAR activators for use in the compositions of the present invention are lipid activators of the α subtype of PPARs.

[0037] The terms “activator of peroxisome proliferator-activated receptor α subtype” or “PPARα activator” in this application refer to lipids that activate the nuclear receptor PPARα.

[0038] Examples of lipid PPARα activators that meet the requirements of the reporter gene assay (Kliewer et al., (1992) Nature, 358, 771-774) include C10-C18 saturated fatty acids, which are preferably branched, or if straight-chain, preferably derivatized (e.g. with hydroxyl groups), C10-C20 monounsaturated fatty acids, and C10-C22 polyunsaturated fatty acids.

[0039] Fatty acids can be straight-chain or branched, saturated or unsaturated, and can be substituted, for example, hydroxylated, such as α-hydroxy or β-hydroxy derivatives. The corresponding alcohols, triglycerides, and phospholipids of any of these acids are also suitable for this invention. Preferred derivatives include those derived from acids with carboxyl substitutions, such as esters (e.g., triglycerides, monoglycerides, diglycerides, phosphate esters), amides (e.g., ceramide derivatives), and salts (e.g., alkali metal and alkaline earth metal salts, ammonium salts). In the case of triglyceride derivatives, all isomers at all positions on the glycerol backbone are included.

[0040] Therefore, oils rich in fatty acid triglycerides are also suitable for this invention. Such oils are commercially available and include coriander seed oil (rich in apigenin), parsley seed oil (rich in apigenin), evening primrose oil (rich in gamma-linolenic acid), borage seed oil (rich in gamma-linolenic acid), shea butter (rich in oleic acid and linoleic acid), fish oil and its concentrates (rich in DHA and EPA), crab oil (rich in erucic acid), flaxseed oil (rich in alpha-linolenic acid), almond oil (rich in oleic acid), and cottonseed oil (rich in linoleic acid).

[0041] Preferred PPARα activators according to the present invention are 10-hydroxystearic acid, 12-hydroxystearic acid, cis-perilla acid, trans-7-octadecenoic acid, cis-5,8,11,14,17-eicosapentaenoic acid, cis-4,7,10,13,16,19-docosahexaenoic acid, conjugated linoleic acid (C9,T11), gulombinic acid, trans-linolenic acid, trans-ricinolenic acid, octadecanoic acid, 2-hydroxystearic acid, α-linolenic acid, arachidonic acid, cis-11,14-eicosadienoic acid, conjugated linoleic acid (T10,C12), conjugated linoleic acid (T9,T11), conjugated linoleic acid (a 50:50 mixture of C9,T11 and T10,C12), coriander acid, trans-linoleic acid, and monopenetroselinic acid. (acid), apigenin, ricinoleic acid, stearylene acid, arborvitae extract and trans isoleic acid.

[0042] Other suitable preferred PPARα activators include cis-11,14,17-eicosalicylic acid, cis-5-eicosalicylic acid, cis-8,11,14-eicosalicylic acid, hexadecanoic acid, palmitoleic acid, trans-petroselaidic acid, trans-trans-farnesol, cis-13,16-docosadienoic acid, cis-isooleic acid, cis-11-eicosalicylic acid, cis-13,16,19-docosatrienoic acid, cis-13-octadecanoic acid, cis-15-octadecanoic acid, cis-7,10,13,16-docosatraenoic acid, transoleic acid, gamma-linolenic acid, geranilic acid, geraniylgeranilic acid, linoleic acid, oleic acid, and petroselinyl. (alcohol), phytic acid, pine nut oil acid, trans-13-octadecenoic acid, tridecyl salicylic acid (TDS).

[0043] Other suitable categories of PPARα activators include plant extracts such as chickpea extract (red clover phytoestrogens), chromolaena odorata extract, pomegranate saponifiable hydrolysate extract, buglossoides (octadecanoic acid plant extract), and zanthalene (extract from Sichuan pepper).

[0044] When combined with phellandic acid and / or DHA (or its derivatives) according to the present invention, the lipids are particularly preferred due to their excellent anti-aging effects. The lipids are selected from the group consisting of polyunsaturated fatty acids such as linoleic acid, conjugated linoleic acid, linolenic acid, eicosapentaenoic acid, arachidonic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) (for DHA, only when the first lipid in the composition of the present invention is PA or its derivative), monounsaturated fatty acids such as phellandic acid (for PA, only when the first lipid in the composition of the present invention is DHA or its derivative), transoleic acid, oleic acid, erucic acid, and diacids such as hexadecanedioic acid.

[0045] It should also be understood that the PPARα activator present in the compositions according to the invention is ideally present in an "active" form; that is, it is not esterified. Therefore, although natural sources of materials such as oils have been mentioned above, the PPARα activator used in the compositions according to the invention is preferably not the original, esterified form of the activator, but a source of raw material rich in unesterified PPARα activator, or a source of raw material in which the esterified form is hydrolyzed to release fatty acids.

[0046] This invention includes a PPAR activator, more preferably a PPARα activator. Preferably, the PPAR activator is present in the composition of this invention in an amount of 0.001% to 5% by weight of the liquid cleaning composition, more preferably 0.008% to 4.5% by weight, and most preferably in the range of 0.01% to 4% by weight.

[0047] Hydroxystearic acid The most preferred PPAR activator of the present invention is hydroxystearic acid or a derivative thereof. Preferably, the cleaning composition of the present invention comprises hydroxystearic acid or a derivative thereof. Hydroxystearic acid is a C18 chain fatty acid having one or more OH groups present along a hydrocarbon chain. Typically, 12-HySA and 10-HySA are well-known hydroxystearic acids. It is commonly used as an emollient in skin care products and is also a common soap ingredient due to its surfactant properties.

[0048] The present invention includes hydroxystearic acid, more preferably 12-hydroxystearic acid and 10-hydroxystearic acid, and most preferably 12-hydroxystearic acid. Preferably, the amount of hydroxystearic acid in the liquid cleaning composition of the present invention is 0.001% to 5% by weight, more preferably 0.008% to 4.5% by weight, and most preferably 0.01% to 4% by weight.

[0049] Complex carbohydrates The soap composition of the present invention comprises complex carbohydrates. There are two types of carbohydrates: simple and complex. Simple carbohydrates consist of one or two sugar molecules. Complex carbohydrates include starch and fiber.

[0050] Preferably, the complex carbohydrate is a polysaccharide, and most preferably it contains starch. Simultaneously, the polysaccharide has the general formula C2. x (H2O) y Where x and y are typically large numbers between 200 and 2500. When the repeating unit in the polymer backbone is a six-carbon monosaccharide, as is the case in general, the general formula simplifies to (C6H... 10 O5) n , where typically 40 ≤ n ≤ 3000.

[0051] Preferably, the range of starch carbohydrates in the soap composition is 1-45% by weight of the soap composition, more preferably 3-40% by weight, and most preferably 5-35% by weight.

[0052] Starch (a polymer of glucose) is preferably a polysaccharide used in plants as a storage medium for polysaccharides, existing in the form of amylose and amylopectin. In animals, a structurally similar glucose polymer is a more densely branched glycogen, sometimes referred to as "animal starch".

[0053] Preferably, the starch comprises at least 20% by weight of the complex carbohydrates, more preferably at least 30%, 40%, 50%, 60%, or 70% by weight of the complex carbohydrates, more preferably at least 80% by weight, further preferably at least 85% by weight, and most preferably at least 90% by weight. In a highly preferred aspect, the starch comprises at least 95% by weight of the complex carbohydrates.

[0054] Preferably, the composition of the present invention comprises 0.01 to 20% by weight of the composition, more preferably 0.08 to 5% by weight, even more preferably 0.1 to 4.2% by weight, and most preferably 0.15 to 4% by weight of starch. Particularly preferred is that the starch content is in the range of 0.15 to 3.5% by weight of the composition of the present invention.

[0055] In another aspect of the invention, the complex carbohydrate is natural starch or modified starch. Most preferably, the starch is natural starch.

[0056] Suitable starch materials include natural starch (from corn, wheat, rice, potatoes, cassava, etc.), pregelatinized starch, various physically and chemically modified starches, and mixtures thereof. The term natural starch refers to starch that has not been chemically or physically modified—also known as native starch or natural starch.

[0057] Preferred starches are natural or native starches derived from corn, cassava, wheat, potato, rice, and other natural starch sources. Native starches with different ratios of amylose and amylopectin are available, for example, corn (25% amylose); waxy corn (0%); high amylose corn (70%); potato (23%); rice (16%); sago (27%); cassava (18%); wheat (30%); peas (35% amylose), etc. Native starches can be used directly or modified during the preparation of liquid personal care compositions to gelatinize the starch. Preferably, the starch is unmodified, partially or non-gelatinized, or pregelatinized. Most preferably, ungelatinized or pregelatinized starch is used. Further preferred are natural and unmodified starches.

[0058] Another suitable starch is pregelatinized starch, which is gelatinized before being added as a component of the liquid personal care composition of the present invention. Various forms of gelatinization at different temperatures are available, such as cold water-dispersible starch.

[0059] Gelatinized starch is the result of starch granules breaking down and dissolving in water when heated; this process is called starch gelatinization. Starch that has not undergone this treatment can be called "ungelatinized starch".

[0060] Preferably, the starch is in a suspended state in the liquid composition of the present invention; and most preferably, it is in a concentrated form in which it does not function as a thickener. More preferably, the starch is used in an ungelatinized form. It is known in the art that ungelatinized starch does not function as a thickener.

[0061] Preferably, when the starch particle size is in the range of 2-50 μm, more preferably 4-45 μm, and most preferably 5-35 μm, the particle shape can be a smooth ellipse, oblate spheroid, or polygonal, preferably a smooth ellipse / sphere. Most preferably, natural starch with a particle size in the range of 2-50 μm, more preferably 4-45 μm, and most preferably 5-35 μm is used.

[0062] Non-soap surfactants Preferably, the cleaning composition comprises 0.1 to 40% by weight, more preferably 1 to 35% by weight, even more preferably 2 to 30% by weight, and most preferably 5 to 25% by weight, of a non-soap surfactant based on the weight of the cleaning composition. The compositions of the present invention may contain anionic surfactants, nonionic surfactants, cationic surfactants, or amphoteric surfactants, or combinations thereof.

[0063] The synthetic anionic detergent active material that can be used in this invention can be an aliphatic sulfonate, such as a primary alkane (e.g., C8-C4). 22 ) sulfonates, primary alkanes (e.g., C8-C 22 disulfonates, C8-C 22 Olefin sulfonates, C8-C 22 Hydroxyalkyl sulfonates or alkyl glycerol ether sulfonates (AGS); or aromatic sulfonates, such as alkylbenzene sulfonates. Anionic surfactants can also be alkyl sulfates (e.g., C14). 12 -C 18 Alkyl sulfates or alkyl ether sulfates (including alkyl glycerol ether sulfates). Anionic surfactants may also contain mild surfactants, such as aminocarboxylic acids or their derivatives, for example, aminocarboxylic acids containing sulfur / salt / ester / N-acyl derivatives and having glycine salt, glutamate, taurine, hydroxyethyl sulfonate functional groups and C12, C14 chains.

[0064] Anionic surfactants can also be alkyl sulfonyl succinates (including mono- and di-alkyl, e.g., C6-C). 22 sulfosuccinates; alkyl and acyl taurates, alkyl and acyl sarcosinates, sulfoacetates, C8-C 22 Alkyl phosphates and phosphates, alkyl phosphate esters and alkoxyalkyl phosphate esters, acyl lactates, C8-C 22Monoalkyl succinates and maleates, sulfoacetates, alkyl glucosides and acyl hydroxyethyl sulfonates, etc.

[0065] Sulfosuccinates can be monoalkyl sulfosuccinates having the following formula: R 4 O2CCH2CH(SO3M)CO2M; and The following formula is amide-MEA sulfosuccinate: R 4 CONHCH2CH2O2CCH2CH(SO3M)CO2M Where R 4 The range is C8-C 22 Alkyl group and M is a solubilizing cation.

[0066] Sarcosine salts are usually represented by the following formula: R 1 CON(CH3)CH2CO2M, Where R 1 The range is C8-C 20 Alkyl group and M is a solubilizing cation.

[0067] Taurine salts are usually represented by the following formula: R 2 CONR 3 CH2CH2SO3M Where R 2 The range is C8-C 20 Alkyl, R 3 The range is C1-C4 alkyl and M is a solubilizing cation.

[0068] The cleaning composition of the present invention may contain C8-C 18 Acyl hydroxyethyl sulfonates. These esters are prepared by reaction of an alkali metal hydroxyethyl sulfonate with a mixture of aliphatic carboxylic acids having 6 to 18 carbon atoms and an iodine value less than 20. At least 75% of the mixed carboxylic acids have 12 to 18 carbon atoms and up to 25% have 6 to 10 carbon atoms.

[0069] Acylhydroxyethyl sulfonate can be an alkoxylated hydroxyethyl sulfonate, as described in U.S. Patent No. 5,393,466 to Ilardi et al., entitled “Fatty Acid Esters of Polyalkoxylated Isethonic Acid,” issued February 28, 1995; which is incorporated herein by reference. Such compounds have the following general formula: RC-(O)OC(X)HC(Y)H2-(OCH-CH2) m -SO3M + , Where R is an alkyl group having 8 to 18 carbons, m is an integer from 1 to 4, X and Y are hydrogen or alkyl groups having 1 to 4 carbons, and M + It is a monovalent cation, such as sodium, potassium or ammonium.

[0070] The most preferred anionic surfactant used in the compositions of the present invention is selected from sulfonic acids, their salts, alkyl ether sulfates, mixtures and combinations thereof. The most preferred anionic surfactant may include sodium dodecyl ether sulfate, its derivatives, such as ethylene oxide derivatives, etc.

[0071] Preferably, the cleaning composition comprises an anionic surfactant in the range of 0.1 to 40% by weight, more preferably 1 to 35% by weight, even more preferably 2 to 30% by weight, and most preferably 5 to 25% by weight, based on the weight of the composition.

[0072] Preferably, the cationic surfactant used for the purposes of this invention is, for example, a quaternary ammonium surfactant, including but not limited to, benzalkonium chloride. Preferably, the cleaning composition comprises 0.1 to 40% by weight, more preferably 1 to 35% by weight, further more preferably 2 to 30% by weight, and most preferably 5 to 25% by weight, of the cationic surfactant.

[0073] Preferably, the amphoteric surfactant used for the purposes of this invention is, for example, an acyl / dialkylethylenediamine, such as sodium acylamphoacetate, cocamidopropyl betaine (CAPB), hydroxysulfonate derived from coconut fatty acids or lauric acid, disodium acylamphodipropionate, alkyl betaine, alkylamidopropyl betaine, alkylamidopropyl hydroxysulfonate alkylamine, alkylsulfonate, amine oxides, alkylimidazolium and ethoxylated amines, disodium alkylamphodiacetate, sodium acrylamphohydroxypropyl sulfonate, disodium acylamphodiacetate and sodium acylamphodipropionate, N-alkyl amino acids, such as aminopropylalkylglutamine, alkylaminopropionic acid, sodium alkylimidazolium dipropionate and lauroylamphocarboxyglycine salt. Preferably, the cleaning composition contains an amphoteric surfactant in the range of 0.01 to 10% by weight of the composition, more preferably in the range of 0.1 to 8% by weight, even more preferably in the range of 1 to 7% by weight, and most preferably in the range of 2 to 6% by weight.

[0074] Preferably, the composition comprises a combination of anionic synthetic surfactant and amphoteric surfactant (e.g., betaine), especially when the anionic surfactant accounts for 50% or more of such synthetic surfactant mixture.

[0075] One or more nonionic surfactants can be used as co-surfactants in the cleaning compositions of the present invention. The nonionic surfactants are preferably used at levels as low as 5%, 7.5%, or 10% by weight and as high as 20%, 25%, or 30% by weight. Nonionic surfactants that can be used particularly include compounds having hydrophobic groups and reactive hydrogen atoms (e.g., fatty alcohols, acids, amides, or alkylphenols) reacting with alkyl oxides (especially ethylene oxide alone) or with propylene oxide. Specific nonionic detergent compounds are alkyl (C6-C4) compounds. 22 ) Phenolic ethylene oxide condensates, aliphatic (C8-C) 18 The condensation products of primary or secondary straight-chain or branched alcohols with ethylene oxide, as well as products obtained by the condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine. Other so-called nonionic detergent compounds include long-chain tertiary amine oxides, long-chain tertiary phosphine oxides, and dialkyl sulfoxides.

[0076] Preferred nonionic surfactants include alkyl polyglucosides and carboxylic acid / alcohol ethoxylates having the following structures. a) HOCH2(CH2) n (CH2CH2O) x H or b) HOOC(CH2) m (CH2CH2O) y H; Where m and n are independently <18; and x and y are independently >1; preferably m and n are independently 6 to 18; and x and y are independently 1 to 30; c) HOOC(CH2) i -CH=CH-(CH2) k (CH2CH2O) z H; Where i and k are independently 5 to 15; and z is independently 5 to 50; preferably i and k are independently 6 to 12; and z is independently 15 to 35.

[0077] Nonionic surfactants may also include glycoamides, such as polysaccharide amides. Specifically, the surfactant may be one of the lactosamides described in U.S. Patent No. 5,389,279, entitled "Compositions Comprising Nonionic Glycolipid Surfactants," issued February 14, 1995, by Au et al.; or may be one of the glycoamides described in U.S. Patent No. 5,009,814, entitled "Use of N-Poly Hydroxyalkyl FattyAcid Amides as Thickening Agents for Liquid Aqueous Surfactant Systems," issued April 23, 1991, by Kelkenberg; or may be one of the glycoamides described in this application by introduction.

[0078] Preferably, the nonionic surfactant used for the purposes of this invention is, for example, an alkanolamide such as cocamide MEADEA / MIPA, an ester produced by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan anhydride or other alcohols and esters, such as ethoxylated alcohols, ethoxylated lanolin, ethoxylated polysiloxanes, propoxylated POE ethers, and alkyl glycosides such as lauryl glucoside, decyl glucoside, and cocoyl glucoside. Preferably, the cleaning composition comprises 0.01 to 10% by weight of the composition, more preferably 0.1 to 8% by weight, further more preferably 1 to 7% by weight, and most preferably 2 to 6% by weight of a nonionic surfactant.

[0079] Suitable surfactants that can be used in the formulations disclosed herein may include one or more of sodium cocoyl hydroxyethyl sulfonate, sodium lauryl sulfate, disodium lauryl sulfosuccinate, lauryl glucoside, myristyl glucoside, decyl glucoside, sodium sulfate, sodium silicate, cocamidopropyl betaine, sodium cocoyl sulfate, and sodium dodecyl sulfate. In one embodiment, the surfactant may include sodium cocoyl hydroxyethyl sulfonate. In another embodiment, the surfactant may include disodium dodecyl sulfosuccinate. In a further embodiment, the surfactant may include a mixture of dodecyl glucoside, myristyl glucoside, sodium sulfate, sodium silicate, and sodium cocoyl sulfate. In yet another embodiment, the surfactant may include sodium lauryl sulfate. Suitable surfactants are not limited to those listed herein, but may include other surfactants that are in powder form and water-soluble prior to their incorporation into the formulation to maximize the cleaning potential of the formulation.

[0080] Co-surfactants For the purposes of this invention, alkoxylated nonionic surfactants (which are a class of nonionic surfactants) are specifically defined as co-surfactants. Furthermore, only for the purposes of this invention, alkoxylated nonionic surfactants as co-surfactants are distinguished from other nonionic surfactants previously defined because they contain at least two or more alkyl epoxide groups. (Conversely, nonionic surfactants having fewer than two EO groups are considered to be the surfactants described in the preceding paragraphs). Examples of alkoxylated nonionic surfactants include, but are not limited to, condensation products of straight-chain or branched aliphatic alcohols, acids, phenols, esters, glycerides, amines, and amides. Preferred co-surfactants are ethoxylated nonionic surfactants having 2-12, most preferably 2-6 ethylene oxide (EO) groups. Particularly preferred nonionic surfactants are ethoxylated fatty amides having 2-12, most preferably 2-6 (EO) groups. Alkoxylated fatty alcohols may also be used as co-surfactants.

[0081] Preferably, the compositions of the present invention contain a co-surfactant in the range of 0 to 10% by weight, more preferably 2 to 8% by weight, and most preferably 3 to 7% by weight.

[0082] electrolytes The cleaning compositions of the present invention may contain electrolytes. Electrolytes used for the purposes of the present invention may include inorganic salts (e.g., sodium chloride, potassium chloride) and organic salts (e.g., sodium citrate). In addition to the chlorides and citrates described above, other salts include phosphates, sulfates, and other halide salts. The counterions of such salts may be sodium or other monovalent cations, as well as divalent and trivalent cations.

[0083] The cleaning formulation may optionally contain an electrolyte. When present, the electrolyte may range from 0.01 to 5% by weight of the liquid cleaning composition, more preferably from 0.1 to 4.5% by weight, and most preferably from 0.1 to 4.5% by weight. These weight percentage values ​​include cases where the electrolyte is used as a rheology modifier.

[0084] Chelating agents The cleaning composition of the present invention may contain a chelating agent. Preferably, the chelating agent in the cleaning composition is present in the range of 0.1 to 3% by weight of the cleaning composition, more preferably in the range of 0.2 to 2.5% by weight of the cleaning composition, and most preferably in the range of 0.2 to 1.5% by weight of the cleaning composition.

[0085] Preferably, the chelating agent in the cleaning composition is present at a weight of at least 0.1% by weight, more preferably at least 0.8% by weight, and most preferably at least 1% by weight.

[0086] Preferably, the chelating agent in the cleaning composition is present at a maximum of 3% by weight of the cleaning composition, more preferably at a maximum of 2.5% by weight, even more preferably at a maximum of 2% by weight, and most preferably at a maximum of 1.5% by weight.

[0087] Preferred chelating agents are as follows (the abbreviations are in parentheses after the names): Ethylenediaminetetraacetic acid (EDTA), disodium ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid (DTPA), ethane-1-hydroxy-1,1-diphosphonic acid (EHDP), ethylenediamine-N,N′-disuccinic acid (EDDS), hypozinotriacetic acid (NTA), sodium iminodisuccinate (IDS), ethylene glycol-bis-(2-aminoethyl)-N,N,N′,N′-tetraacetic acid (EGTA), methylglycine diacetic acid (MGDA), N-(2-hydroxyethyl)ethylenediaminetetraacetic acid (HEDTA), ethylenediaminetetramethylene Phosphonic acid (EDTMP), diethylenetriamine-pentamethylenephosphonic acid (DTPMP), glutamic acid-N,N-diacetic acid (GLDA), sodium gluconate, cyclohexane-1,2-diamine-N,N′,N′,N'-tetraacetic acid (CDTA), 1,3-propanediaminetetraacetic acid (PDTA), ethylenediaminetetraacetic acid (EDTA), L-hydroxyiminodisuccinic acid (L-IDS), trisodium N-carboxyethyliminosuccinate (CEIS), citric acid, sodium tripolyphosphate (STP), and triethylenetetraaminehexaacetic acid (TTHA). Other preferred chelating agents are trisodium ethylenediaminedisuccinate, tetrasodium iminodisuccinate, tetrasodium glutamic acid-N,N-diacetic acid, sodium 2-hydroxyethyliminodisuccinate (disodium ethanol diglycine), tetrasodium 3-hydroxy-2,2-iminodisuccinate, trisodium methylglycine diacetate, and tetrasodium L-aspartic acid-N,N-diacetic acid. More preferred chelating agents are salts of ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA). Preferred EDTA salts are disodium ethylenediaminetetraacetic acid and tetrasodium ethylenediaminetetraacetic acid. Preferred DTPA salts are pentasodium diethylenetriaminepentaacetic acid.

[0088] Most preferably, the chelating agent suitable for the compositions of the present invention is selected from ethylenediaminetetraacetic acid (EDTA), or diethylenetriaminepentaacetic acid (DTPA), its derivatives and combinations thereof, and mixtures thereof. EDTA derivatives are selected from tetrasodium EDTA, trisodium EDTA, disodium EDTA, and combinations thereof. DTPA derivatives are selected from tetrasodium DTPA, trisodium DTPA, disodium DTPA, and combinations thereof.

[0089] preservative The cleaning composition of the present invention may contain a preservative. Preferably, the preservative in the cleaning composition is present in the range of 0.1 to 3% by weight of the cleaning composition, more preferably in the range of 0.1 to 2% by weight of the cleaning composition, and most preferably in the range of 0.1 to 1% by weight of the cleaning composition.

[0090] Examples of very useful preservatives suitable for the compositions of the present invention include, but are not limited to, chlorite components, sorbic acid components, and mixtures thereof.

[0091] Other preferred preservatives include, but are not limited to, those commonly used in cosmetics, such as dibromo-2-bromomethylglutaronitrile (2-bromo-2-bromomethylglutaronitrile), phenoxyethanol, 3-iodo-2-propynyl butylcarbamate, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl hamstoff, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-chloroacetamide, benzalkonium chloride, and benzyl alcohol.

[0092] According to the present invention, the preservative is particularly preferred from methylisothiazolinone, methylchloroisothiazolinone, 3-iodo-2-propynyl butylcarbamate (IPBC), DMDM ​​hydantoin and benzyl alcohol and / or mixtures or combinations thereof.

[0093] water The cleaning composition of the present invention comprises water in the range of 5 to 80% by weight, more preferably 5 to 78% by weight, and most preferably 10 to 75% by weight, based on the weight of the composition. The composition of the present invention is primarily an aqueous composition.

[0094] rheology modifiers The compositions of the present invention contain rheology modifiers, which are agents that affect the rheological properties of liquid cleaning compositions. These agents may be thickeners such as polymers, and may include electrolyte salts that can alter the rheological properties of the liquid cleaning composition. Based on the weight of the cleaning composition of the present invention, the compositions of the present invention may contain rheology modifiers in the range of 0.01 to 10% by weight, more preferably 0.1 to 9% by weight, and most preferably 0.5 to 8.5% by weight.

[0095] Thickeners can be water-soluble / water-dispersible polymers. These polymers can be cationic, anionic, amphoteric, or nonionic, and have a molecular weight greater than 100,000 Daltons. They are known to improve the viscosity and stability of liquid detergent compositions, enhance the sensory feel on and off the skin during use, and enhance the creaminess and stability of foam. When present, the amount of the polymer can range from 0.01 to 10% by weight of the composition. Preferably, the thickening polymer is present in the range of 0.01 to 10% by weight of the cleaning composition of the present invention, more preferably 0.1 to 9% by weight, and most preferably 0.5 to 8.5% by weight.

[0096] Examples of water-soluble / or water-dispersible polymers and rheology modifiers include gums such as cellulose gum, microcrystalline cellulose, cellulose gel, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, methyl cellulose, ethyl cellulose, guar gum, gum arabic, gum arabic, gum acacia, agar gum, xanthan gum, and mixtures thereof; alkali-swellable acrylic polymers such as cross-linked acrylate copolymers, polyacrylate cross-linked polymers; polyacrylate cross-linked polymers (Sepimax zen), lightly cross-linked acrylate copolymers (Carbopol Aqa SF01), hydroxypropyl methyl cellulose (and) cellulose gum (and) xanthan gum (TEXTURE PURE SA), Amaze XT (dehydroxanthan gum); emulsion polymers such as Aculyn® 28; cationic polymers such as modified polysaccharides, including cationic guar gum such as Jaguar® C13S, Jaguar® C17, or Jaguar® C16; and cationic modified cellulose such as UCARE® Polymer JR 30 or JR. 40; N-Hance® 3000, N-Hance® 3196, N-Hance® GPX 215, or N-Hance® GPX 196 from Hercules; synthetic cationic polymers such as Merquat® 100, Merquat® 280, Merquat® 281, and Merquat® 550 sold by Nalco; cationic galactomannans such as the Galactasol® 800 series from Henkel, Inc.; Quadrosoft® LM-200; and Polyquaternium-24®. High molecular weight polyethylene glycols such as Polyox® WSR-205 (PEG 14M), Polyox® WSR-N-60K (PEG 45), and Polyox® WSR-301 (PEG 90M) are also suitable. Other cationic cellulose derivatives are cationic guar gum derivatives.

[0097] The electrolytes mentioned above can be used as rheology modifiers.

[0098] For the purposes of this invention, the rheology modifier is not starch, and more preferably not ungelatinized starch.

[0099] pH Preferably, the pH range of the composition of the present invention is 4.5 to 11. When the liquid cleaning composition of the present invention contains soap, the pH range may be 9 to 11. When the liquid cleaning composition of the present invention does not contain soap or the soap content is less than 1% by weight, the pH range may be 4 to 7.

[0100] The pH of a solution can be expressed as the negative logarithm of hydrogen ion activity, which is related to the millivolt potential of the pH indicator electrode. This electrode is calibrated using a standard buffer mixture whose pH value falls on either side of the pH of the solution being measured (acidic or alkaline). Approximately 1 gram of the cleaning composition is weighed into a beaker, and brought to 100 grams by adding distilled water at 25°C, and the pH value is measured.

[0101] soap The liquid cleaning composition of the present invention may contain about 0.1 to 40% by weight of soap, more preferably 2 to 30% by weight, and most preferably about 2.5 to 25% by weight of soap, based on the weight of the cleaning composition. Preferably, the cleaning composition has 0.1 to 40% by weight of total fatty substances (TFM).

[0102] The term soap refers to a salt of fatty acids, wherein the accompanying cation can be an alkali metal, alkaline earth metal, or ammonium ion, preferably an alkali metal. Preferably, the cation is sodium or potassium. Soap can be saturated or unsaturated, depending on the nature of the corresponding fatty acid and / or oil used for saponification.

[0103] Moisturizer "Emollients" are defined as substances that soften or improve the elasticity, appearance, and youthfulness of the skin (stratum corneum) by increasing its water content, adding or replacing lipids and other skin nutrients, or both, and by maintaining its softness by slowing down the decrease in its water content.

[0104] Moisturizers (which are also humectants, such as polyhydroxy alcohols, for example, glycerol and propylene glycol; and polyols, such as polyethylene glycol, such as Polyox WSR N-60K (PEG-45M)) are used in preferred embodiments of the invention. The moisturizer is preferably used in amounts of at least 0.5% by weight, 2.5% by weight, or 5% by weight, and at most 15% by weight, 20% by weight, or 25% by weight.

[0105] Hydrophobic emollients are used in preferred embodiments of the invention. Preferably, they are hydrophobic emollients having a weight-average particle size of less than 1000 or 500 micrometers in diameter, and are defined herein as “finely dispersed oils.” These emollients are preferably used in amounts of a minimum of 0.5 wt%, 2.5 wt%, or 5 wt%, and a maximum of 15 wt%, 20 wt%, or 25 wt%.

[0106] Suitable hydrophobic emollients include, but are not limited to, the following: (a) Silicone oils and their modifiers, such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl and aryl silicone oils; (b) Fats and oils, including natural fats and oils (triglycerides), such as jojoba oil, soybean oil, sunflower oil, rice bran oil, avocado oil, almond oil, olive oil, sesame oil, peach kernel oil, castor oil, coconut oil and mink oil; cocoa butter; beef tallow, lard; hardened oils obtained by hydrogenation of the above oils; and synthetic monoglycerides, diglycerides and triglycerides, such as glyceryl myristate and glyceryl 2-ethylhexanoate; (c) Waxes, such as carnauba wax, cetacean wax, beeswax, lanolin and their derivatives; (d) Hydrophobic plant extracts; (e) Hydrocarbons, such as petrolatum, polybutene, liquid paraffin, microcrystalline wax, ceresin, squalene, pristan and mineral oil; (f) Higher alcohols, such as lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cholesterol and 2-hexyldecyl alcohol; (g) Esters, such as cetyl caprylate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glyceryl monostearate, glyceryl distearate, glyceryl tristearate, alkyl lactate, alkyl citrate, and alkyl tartrate; (h) Essential oils and their extracts, such as peppermint, jasmine, camphor, white cedarwood, bitter orange peel, ryu, turpentine, cinnamon, bergamot, Satsuma mandarin, calamus, pine, lavender, bay leaf, clove, cypress, eucalyptus, lemon, starflower, thyme, peppermint, rose, sage, sesame, ginger, basil, juniper, lemongrass, rosemary, rosewood, avocado, grape, grape seed, myrrh, cucumber, watercress, calendula, elderflower, geranium, linden flower, amaranth, seaweed, ginkgo, ginseng, carrot, guarana, tea tree, jojoba, comfrey, oats, cocoa, orange blossom, vanilla, green tea, pennywort. royal), aloe vera, menthol, eucalyptol, eugenol, citral, citronellol, borneol, linalool, geraniol, evening primrose, camphor, thymol, spirostol, pentene, limonene, and terpene oils; (i) Mixtures of any of the above components, etc.

[0107] Form and format The liquid personal care compositions of the present invention are preferably end-use personal care compositions, such as shower gels, hand sanitizers, facial cleansers, reconstituted liquids, reconstituted solids, concentrates, self-foaming agents, scrubs, concentrated essence shower gels, and concentrated body masks. However, the composition may also be in the form of a liquid concentrate capable of being reconstituted into a diluted end-use personal care composition. The compositions of the present invention may also be in the form of a self-foaming personal care composition using a foaming agent. Similarly, the rheology modifier may be adjusted accordingly depending on the form and format of the selected composition. The weight percentage of water may also be selected depending on the form and format of the cleaning composition. For example, if the cleaning composition is a liquid cleaning concentrate, less water is present in the composition compared to the higher water weight percentage used in preparing the end-use liquid personal care composition.

[0108] Beneficial agents In addition to the ingredients described above, preferred embodiments of the cleaning composition may also include other optional and preferred ingredients due to their known benefits. The type and amount depend largely on the nature and type of the cleaning composition and general pharmaceutical principles.

[0109] Other optional compositions may contain one or more skin-benefiting agents. The term "skin-benefiting agent" is defined as a substance that softens or improves the elasticity, appearance, and youthful appearance of the skin (stratum corneum) by increasing its water content, adding or replacing lipids and other skin nutrients, or both; and by maintaining its softness by slowing the decrease in its water content. Suitable skin-benefiting agents include emollients, including, for example, hydrophobic emollients, hydrophilic emollients, or blends thereof. Water-soluble skin-benefiting agents may optionally be formulated into the liquid compositions of the present invention. A variety of water-soluble skin-benefiting agents may be used, and the level may be 0 to 50% by weight of the composition, but preferably 1 to 30% by weight. These materials include, but are not limited to, polyhydroxy alcohols. Preferred water-soluble skin-benefiting agents are glycerol, sorbitol, polyethylene glycol, sucrose, trehalose, and maltodextrin.

[0110] Water-insoluble skin-beneficial agents can also be formulated into compositions as modifiers and moisturizers. Examples include silicone oils; hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, and mineral oils; and vegetable triglycerides such as sunflower seed oil and cottonseed oil.

[0111] Preservatives may also be added to the composition to prevent the growth of potentially harmful microorganisms. Suitable conventional preservatives for use in the compositions of the present invention are alkyl esters of hydrobenzoic acid. Other preservatives that have recently come into use include caprolactone derivatives, propionates, and various quaternary ammonium compounds. Particularly preferred preservatives are phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, and benzyl alcohol. The selection of preservatives should take into account the intended use of the composition and possible incompatibilities between the preservative and other components. Preservatives are preferably used in amounts ranging from 0.01% to 2% by weight of the composition.

[0112] A variety of other optional materials can be formulated into the composition. These may include: antimicrobial agents; scrubs and exfoliating particles, such as polyethylene with silica or alumina; cooling agents, such as menthol; skin soothing agents, such as aloe vera; and colorants.

[0113] Shower gels or washes may contain particles with an average diameter of approximately 50 μm, which help remove dry skin. Without being bound by theory, the degree of exfoliation depends on the size and morphology of the particles. Large, coarse particles are often very harsh and irritating. Very small particles may not be effective exfoliants. Such exfoliants used in the art include natural minerals such as silica, talc, calcite, pumice, tricalcium phosphate; seeds such as rice, apricot kernels, etc.; ground shells such as almond and walnut shells; oats; polymers such as polyethylene glycol and polypropylene glycol beads; petals and leaves; microcrystalline wax beads; jojoba ester beads, etc. These exfoliants exhibit a wide variety of particle sizes and morphologies, ranging from micrometers to millimeters. They also have a range of hardness. Some examples are talc, calcite, pumice, walnut shells, dolomite, and polyethylene.

[0114] Advantageously, active agents other than skin conditioning agents as defined above may also be incorporated into the composition. These active ingredients may advantageously include antibacterial agents, vitamins, anti-acne active substances; anti-wrinkle, anti-skin aging and skin repair active substances; skin barrier repair active substances; non-steroidal cosmetic soothing active substances; artificial tanning agents and accelerators; skin brightening active substances; sunscreen active substances; sebum stimulants; sebum inhibitors; antioxidants; protease inhibitors; skin firming agents; antipruritic ingredients; hair growth inhibitors; 5-α reductase inhibitors; desquamating enzyme enhancers; anti-glycation agents; or mixtures thereof; etc.

[0115] These active agents may be selected from water-soluble active agents, oil-soluble active agents, pharmaceutically acceptable salts, and mixtures thereof. As used herein, the term "active agent" means a personal care active substance that may be used to deliver benefits to the skin and / or hair, and is generally not used to provide skin conditioning benefits delivered via emollients as defined above. As used herein, the term "safe and effective amount" means an amount of active agent that is high enough to alter the condition being treated or to deliver the desired skin care benefit, but low enough to avoid serious side effects. As used herein, the term "benefit" means a therapeutic, preventative, and / or long-term benefit associated with the treatment of a particular condition using one or more of the active agents described herein. The safe and effective amount of an active agent will vary depending on the specific active agent, the ability of the active substance to penetrate the skin, the user's age, health condition, and skin condition, and other similar factors.

[0116] A wide variety of active ingredients can be used in the compositions of the present invention, including those selected from anti-acne active substances, anti-wrinkle and anti-skin aging active substances, skin barrier repair aids, cosmetic soothing aids, local anesthetics, artificial tanning agents and accelerators, skin brightening active substances, antimicrobial and antifungal active substances, sunscreen active substances, sebum stimulants, sebum inhibitors, anti-glycation active substances, and mixtures thereof.

[0117] Anti-acne active ingredients can effectively treat acne vulgaris, a chronic condition of sebaceous gland follicles. Non-limiting examples of useful anti-acne active substances include keratolytic agents such as salicylic acid (o-hydroxybenzoic acid), derivatives of salicylic acid such as 5-octanoyl salicylic acid and 4-methoxysalicylic acid, and resorcinol; retinoids such as retinoic acid and its derivatives (e.g., cis and trans); sulfur-containing D and L amino acids and their derivatives and salts, especially their N-acetyl derivatives, mixtures thereof, etc.

[0118] Skin barrier repair active substances are skin care active ingredients that help repair and replenish the natural moisture barrier function of the epidermis. Non-limiting examples of skin barrier repair active substances include lipids such as cholesterol, ceramides, sucrose esters and pseudoceramides, as described in European Patent Specification No. 556957; ascorbic acid; biotin; biotin esters; phospholipids, mixtures thereof, etc.

[0119] Artificial tanning agents can help mimic natural tanning by increasing melanin in the skin or by creating the appearance of increased melanin production. Non-limiting examples of artificial tanning agents and accelerators include dihydroxyacetone; tyrosine; tyrosine esters such as ethyl tyrosine ester and glucosyl tyrosine ester; mixtures thereof, etc.

[0120] Skin-brightening active ingredients can actually reduce the amount of melanin in the skin, or provide this effect through other mechanisms. Non-limiting examples of skin-brightening active ingredients used in this article include aloe vera extract, α-glycero-L-ascorbic acid, aminotyrosine, ammonium lactate, glycolic acid, hydroquinone, 4-hydroxyanisole, octadecenoic acid; capantathene sulfonate; coenzyme Q10; peptide omega-3; niacinamide; glutathione; vitamins E and C and their oil-soluble and water-soluble derivatives, mixtures thereof, etc.

[0121] Sunscreen active ingredients are also useful. Non-limiting examples of sunscreen agents useful in the compositions of the present invention are those selected from octyl methoxycinnamate (Parsol MCX) and butyl methoxybenzoylmethane (Parsol 1789), 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, oxybenzone, mixtures thereof, etc.

[0122] Protease inhibitors are also useful. Protease inhibitors can be divided into two main categories: proteases and peptidases. Proteases act on specific internal peptide bonds of proteins, while peptidases act on peptide bonds adjacent to the free amino or carboxyl groups at the ends of proteins and thus cleave proteins from the outside. Protease inhibitors suitable for the personal liquid cleaning compositions of the present invention include, but are not limited to, proteases such as serine proteases, metalloproteinases, cysteine ​​proteases, and aspartic proteases, and peptidases such as carboxypeptidases, dipeptidases, and aminopeptidases, and mixtures thereof.

[0123] The active ingredients in the cleaning compositions of the present invention may also include antipruritic ingredients. Suitable examples of antipruritic ingredients that can be used in the compositions of the present invention include hydrocortisone, methdilizine, and trimeprazine, mixtures thereof, etc.

[0124] Non-limiting examples of hair growth inhibitors that can be used in the liquid personal care compositions of the present invention include 17-β-estradiol, anti-angiogenic steroids, turmeric extract, cyclooxygenase inhibitors, evening primrose oil, linoleic acid, etc. Suitable 5-α-reductase inhibitors, such as ethinylestradiol, genistine, and mixtures thereof.

[0125] Advantageously, the cationic skin-sensing agent or polymer is used in amounts of about 0.01 wt%, 0.1 wt%, or 0.2 wt% to about 1 wt%, 1.5 wt%, or 2.0 wt%.

[0126] Cationic cellulose can be polymerized in the Polymer JR® and LR® series from Amerchol Corp. (Edison, NJ, USA), such as salts of hydroxyethyl cellulose reacted with trimethylammonium-substituted epoxides, known industrially (CTFA) as Polyquaternium® 10. Another type of cationic cellulose includes polymerized quaternary ammonium salts of hydroxyethyl cellulose reacted with lauryl dimethylammonium-substituted epoxides, known industrially (CTFA) as Polyquaternium® 24. These materials are also available from Amerchol Corp. (Edison, NJ, USA) under the trade name Polymer LM-200®, as well as quaternary ammonium compounds such as alkyl dimethyl ammonium halides.

[0127] Particularly suitable types of cationic polysaccharide polymers that can be used are cationic guar gum derivatives, such as guar hydroxypropyltrimethylammonium chloride (commercially available from Rhone-Poulenc under the JAGUAR® brand). Examples include JAGUAR® C13S, which has a low degree of cationic substitution and high viscosity; JAGUAR® C15, which has a moderate degree of substitution and low viscosity; JAGUAR® C17 (high degree of substitution, high viscosity); JAGUAR® C16, which is a hydroxypropylated cationic guar gum derivative containing low levels of substituent groups and cationic quaternary ammonium groups; and JAGUAR® 162, which is a high-transparency, medium-viscosity guar gum with a low degree of substitution.

[0128] Particularly preferred cationic polymers are JAGUAR® C13S, JAGUAR® C15, JAGUAR® C17, JAGUAR® C16, and JAGUAR® C162, especially JAGUAR® C13S. Other cationic skin-sensing agents known in the art may be used, provided they are compatible with the formulations of the present invention.

[0129] Other preferred cationic compounds that can be used in this invention include amide quaternary ammonium compounds, such as quaternary ammonium propionates and lactates, as well as quaternary ammonium hydrolysates of silk or wheat proteins. Many of these compounds are available from McIntyre Group Ltd. (University Park, Ill.) as Mackine® aminofunctional amines, Mackalene® aminofunctional tertiary amine salts, and Mackpro® cationic protein hydrolysates.

[0130] In embodiments containing a hydrolyzed protein regulator, the average molecular weight of the hydrolyzed protein is preferably about 2500. Preferably, 90% of the hydrolyzed protein has a molecular weight between about 1500 and about 3500. In a preferred embodiment, MACKPRO® WWP (i.e., wheat germ dimethylamine hydrolyzed wheat protein) is added to the strip at a concentration of 0.1% (as is).

[0131] method The cleaning composition of the present invention is prepared using a process comprising the following steps: a. Dissolve a non-soap surfactant and disperse a rheology modifier in water to form an aqueous medium. b. Adding a starch-containing complex carbohydrate to the aqueous medium of step (a) to obtain a liquid cleaning composition of the first aspect; PPAR activator is added during step (a) or (b).

[0132] Preferably, the starch-containing complex carbohydrate is pre-dispersed in a medium such as a polyol (e.g., glycerol or the like).

[0133] Preferably, the PPAR activator is selected from the following: 12-hydroxystearic acid, cis-perilla acid, trans-7-octadecenoic acid, cis-5,8,11,14,17-eicosapentaenoic acid, cis-4,7,10,13,16,19-docosahexaenoic acid, conjugated linoleic acid (C9, T11), gulombinic acid, trans-linolenic acid, trans-ricinolenic acid, octadecanoic acid, 2-hydroxystearic acid, α-linolenic acid, arachidonic acid, cis-11,14-eicosadienoic acid, conjugated linoleic acid (T10, C12), conjugated linoleic acid (T9, T11), and conjugated linoleic acid (C9, T11 and T10). The group consisting of a 50:50 mixture of C12, coriander acid, trans-linoleic acid, monocarboxylic acid, cinnamon oil, stearylene acid, thuja extract, and trans-isooleic acid or combinations thereof. The most preferred PPAR activator is hydroxystearic acid or a derivative thereof, most preferably 10-hydroxystearic acid or 12-hydroxystearic acid or combinations thereof.

[0134] Preferably, 0.1 to 3% by weight of a chelating agent is added to the method of the present invention.

[0135] Preferably, 0.1 to 3% by weight of a preservative is added to the method of the present invention.

[0136] Preferably, in the method of the present invention, the composition comprises 0.01 to 10% by weight of a rheology modifier.

[0137] Preferably, in the method of the present invention, the rheology modifier is selected from electrolytes, cellulose-based polymers, gum-based polymers, acrylate polymers, and mixtures and combinations thereof.

[0138] Preferably, in the method of the present invention, the non-soap surfactant is selected from anionic surfactants, amphoteric surfactants, amphoteric surfactants, or nonionic surfactants.

[0139] Preferably, in the method of the present invention, the composition may further comprise added soap or in-situ generated soap. Most preferably, in-situ added soap is preferred. Free fatty acids are melted in the first step, followed by the addition of a synthetic surfactant and adjustment of the soap formation by alkali, wherein the amount of added soap ranges from 0.1 to 40% by weight.

[0140] use The present invention provides the use of PPAR activator (preferably hydroxystearic acid) and starch-containing complex carbohydrates in a liquid cleansing composition according to the first aspect for providing a uniform skin tone compared to a liquid cleansing composition not containing PPAR activator and starch-containing complex carbohydrates, as measured by various comparative methods.

[0141] The present invention provides the use of a PPAR activator (preferably hydroxystearic acid) and a starch-containing complex carbohydrate in a liquid cleansing composition according to the first aspect for providing skin clarity and spot fading compared to a liquid cleansing composition not containing the PPAR activator and the starch-containing complex carbohydrate, as measured by various comparative methods.

[0142] The present invention provides the use of PPAR activator (preferably hydroxystearic acid) and starch-containing complex carbohydrate in a liquid cleansing composition according to the first aspect for achieving additional skin health, aging, barrier and appearance benefits compared to a liquid cleansing composition not containing PPAR activator and starch-containing complex carbohydrate, as measured by various comparative methods.

[0143] The invention will now be described through the following non-limiting embodiments.

[0144] Example While the invention has been described with reference to specific embodiments thereof, it will be apparent to those skilled in the art that many other forms and modifications of the invention will be readily apparent. The appended claims and the invention itself should generally be construed as covering all such obvious forms and modifications that fall within the true spirit and scope of the invention.

[0145] Example 1: Preparation of formulation The chelating agent was dissolved in an aqueous medium, followed by the addition of solid non-soap surfactants such as sodium lauryl sulfate and cocamide MEA at 70-80°C until dissolved under stirring. Other liquid non-soap surfactants were then added. The rheology-modified acrylate polymer was dispersed in water and then neutralized. Preservatives, colorants, fragrances, and other skin-beneficial additives, including HySA (hydroxystearic acid), were added. Starch pre-dispersed in a glycerol slurry was then added under rapid stirring, and the viscosity was finally adjusted with an electrolyte. The starch was sourced from AGRANA STARKE-STARKINA NATURAL, a 100% natural potato starch of EU origin, typically sourced from Austria and the Czech Republic. The corn was also sourced from AGRANA STARKE-MAISITA 9040, a 100% natural corn starch of EU origin, typically sourced from Austria, Slovakia, and Hungary. The rice was sourced from AGRANA STARKE-REISITA NATURAL, a 100% natural rice starch.

[0146] Examples E1 to E3 were prepared according to the method described above. E1 was prepared without the use of a rheology modifier and contained 12-hydroxystearic acid (12HSA) but no starch. E2 contained an acrylate polymer as a rheology modifier and starch but no 12HSA, while E3 contained an acrylate polymer as a rheology modifier, 12-HSA, and starch. Compositions E1 to E3 were used in clinical studies for gloss and shine, skin texture, uneven skin tone, skin clarity, skin hydration, spot fading, anti-pigmentation, and skin redness.

[0147] Table 1

[0148] Example 2: Clinical research methods and protocols: Gloss and translucency - Comprehensive gloss scale Gloss and translucency were assessed using methods described in (Kumari R et al., Int J Res Dermatol. 2022 nov; 8(6):593-600). A double-blind, randomized clinical trial was conducted under the supervision of dermatologists, who also evaluated the patients. This included panel members on the Fitzpatrick scales 3–6 and, according to the dermatologists, those with dark spots. Panel members were given a washout period to allow for adaptation, and the study duration was extended from a minimum of one week to a maximum of six weeks. The dermatologists used in this study were trained and had validated evaluation skills. The four main visual skin properties influencing G&R assessment were identified as texture, evenness of skin tone, translucency, and hydration.

[0149] Scale and Calculation - The "Multi-Parameter Integrated G&R Scale" is based on visual perceptions of radiance, clarity, skin tone evenness, and blemish reduction. Each parameter is independently assessed on a scale of (1-5) using the provided intermediate rating system. The scale includes all skin colors and ethnicities. The sensitivity of the scale has been validated on colored skin using various skin products (visual representation of the scale on colored skin populations).

[0150] Skin Texture - Report: Subjects undergoing assessment were instructed to wash their face and forearms with water and acclimatize at the test center. Following acclimatization, subjects were assessed by a trained dermatologist using a skin texture scale based on a visible assessment of changes in skin texture in the test area. Skin texture scores ranged from 1 to 5, with lower values ​​indicating rough skin and higher values ​​indicating smooth skin. Skin texture exhibits a transient effect in the presence of topical application, but it may or may not be a stable change, and a statistically significant increase in skin texture score observed after product use is an indication of significant improvement in skin texture.

[0151] Skin tone unevenness - Participants were instructed to wash their face and forearms with water and acclimatize at the test center. After acclimatization, participants were assessed by a trained dermatologist using a skin tone evenness scale, which is based on the assessment of skin color changes over the test area. Skin tone evenness is rated from 1 to 5, with lower values ​​indicating uneven skin tone and higher values ​​indicating even skin tone. Skin tone evenness is a result of phenotypic changes, which are mostly peripheral and difficult to detect, and a statistically significant improvement in skin tone evenness score observed after product use is an indication of significant improvement in skin tone evenness.

[0152] Skin Transparency - Report: Subjects assessed were instructed to wash their face and forearms with water and acclimatize at the test center. After acclimatization, subjects were assessed by a trained dermatologist using a skin transparency scale based on reflectance / luminosity assessment. Skin transparency is rated from 1 to 5, where lower values ​​indicate opaque skin and higher values ​​indicate transparent skin. Skin transparency is a result of phenotypic changes, which are mostly marginal and difficult to detect. A statistically significant improvement in skin transparency score observed after product use is an indication of improved skin transparency.

[0153] Skin Hydration - Report: Subjects assessed were instructed to wash their face and forearms with water and acclimatize at the testing center. After acclimatization, subjects were assessed by a trained dermatologist using a skin hydration scale based on visual hydration assessment. Skin hydration was assessed on a scale of 1-5, where lower values ​​indicate dry skin and higher values ​​indicate moist skin. Skin hydration levels are highly discernible because the skin shows significant results from any type of topical treatment (including water), with only transient effects on skin hydration levels. A statistically significant increase in skin hydration score observed after product use is an indication of improved skin hydration.

[0154] Spot fading, anti-pigmentation, and skin redness reporting – Participants undergoing evaluation were instructed to wash their face and forearms with water and acclimatize at the test center. Following acclimatization, L-shaped spots on selected facial blemishes were assessed using an Antera 3D image analyzer. Improvement and reduction of melanin content and hemoglobin intensity in the forearm. Spot L Improvements in the value indicate fading or disappearance of the assessed spots and an increase in melanin content; a decrease in hemoglobin intensity indicates a reduction in skin pigmentation and redness. Spots L observed after product use A statistically significant increase in melanin content and a decrease in hemoglobin intensity are indicators of fading spots, anti-pigmentation, and reduced skin redness.

[0155] Table 2

[0156] Compositions E1 and E3 were compared using dermatological assessment and image analysis to determine the change in mean CFB-relative baseline values. Appropriate statistical tools were used to analyze radiance and translucency, skin texture, skin clarity, and skin hydration. It was observed that, at 95% confidence limits, the increase in the corresponding parameter values ​​for E3 compared to E1 was statistically significant.

[0157] Table 3

[0158] Compositions E2 and E3 were compared using dermatological assessment and image analysis to determine the change in mean CFB-relative baseline values. Appropriate statistical tools were used to analyze radiance and translucency, skin texture, skin clarity, and skin hydration. It was observed that, at 95% confidence limits, the increase in the corresponding parameter values ​​for E3 compared to E1 was statistically significant.

Claims

1. A liquid personal care composition comprising: i. 0.1 to 40% by weight of non-soap surfactants; ii. 0.01 to 10% by weight of rheology modifier; iii. 0.0001% to 5% by weight of PPAR activator; iv. 0.01 to 4% by weight of starchy complex carbohydrates; and v. 5 to 80% by weight of water; The PPAR activator is 10-hydroxystearic acid or 12-hydroxystearic acid or a combination thereof; and The starch in the composition is in an ungelatinized form.

2. The composition of claim 1, wherein the liquid personal care composition comprises 0.1 to 40% by weight of soap.

3. The composition according to claim 1 or 2, wherein the liquid personal care composition comprises 0.1 to 10% by weight of a polyol.

4. The composition according to any one of claims 1 to 3, wherein the complex carbohydrate comprises at least 50% by weight of starch based on the weight of the complex carbohydrate.

5. The composition according to any one of claims 1 to 4, wherein the starch is natural starch or modified starch.

6. The composition according to any one of claims 1 to 5, wherein the composition comprises 0.1 to 3% by weight of a chelating agent.

7. The composition according to any one of claims 1 to 6, wherein the rheology modifier is selected from thickening polymers and electrolyte salts, or a combination of both.

8. The composition according to any one of claims 1 to 7, wherein the rheology modifier is not ungelatinized starch.

9. The composition according to any one of claims 1 to 8, wherein the non-soap surfactant is selected from anionic surfactants, amphoteric surfactants, amphoteric surfactants, nonionic surfactants, and mixtures thereof.

10. The composition according to any one of claims 1 to 9, wherein the composition contains a preservative in the range of 0.1 to 5% by weight, based on the weight of the composition.

11. A method for preparing a liquid personal care composition according to any one of claims 1 to 10, the method comprising the following steps: a. Dissolve a non-soap surfactant and disperse a rheology modifier in water to form an aqueous medium. b. Adding a starch-containing complex carbohydrate to the aqueous medium of step (a) to obtain the liquid cleaning composition according to any one of claims 1 to 10; The PPAR activator is added during step (a) or (b).

12. Use of a PPAR activator and a starch-containing complex carbohydrate in a liquid cleansing composition according to any one of claims 1 to 10 for providing skin shine compared to a liquid cleansing composition not containing a PPAR activator and a starch-containing complex carbohydrate, wherein the PPAR activator is 10-hydroxystearic acid or 12-hydroxystearic acid or a combination thereof; and wherein the starch is in an ungelatinized form in the composition.

13. Use of a PPAR activator and a starch-containing complex carbohydrate in a liquid cleansing composition according to any one of claims 1 to 10 for providing an even skin tone compared to a liquid cleansing composition not containing a PPAR activator and a starch-containing complex carbohydrate, wherein the PPAR activator is 10-hydroxystearic acid or 12-hydroxystearic acid or a combination thereof; and wherein the starch is in an ungelatinized form in the composition.

14. Use of a PPAR activator and a starch-containing complex carbohydrate in a liquid cleansing composition according to any one of claims 1 to 10 for providing skin clarity compared to a liquid cleansing composition not containing a PPAR activator and a starch-containing complex carbohydrate, wherein the PPAR activator is 10-hydroxystearic acid or 12-hydroxystearic acid or a combination thereof; and wherein the starch is in an ungelatinized form in the composition.

15. Use of a PPAR activator and a starch-containing complex carbohydrate in a liquid cleansing composition according to any one of claims 1 to 10 for fading skin spots compared to a liquid cleansing composition not containing a PPAR activator and a starch-containing complex carbohydrate, wherein the PPAR activator is 10-hydroxystearic acid or 12-hydroxystearic acid or a combination thereof; and wherein the starch is in an ungelatinized form in the composition.

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