Contact lenses and methods related thereto

Abstract

A contact lens (101) includes an optical zone (102). The optical zone (102) includes a central region (105) having curvature centered on an optical axis (19). The central region (105) has a distance-correcting refractive power and a chord diameter of 2.7 mm. The optical zone (102) includes a first annular region (103a) having additional refractive power, an on-axis curvature center, and a width of 0.7 mm. The optical zone (102) includes a second annular region (103b) that is a distance-correcting zone, has an on-axis curvature center, and has a width of 0.6 mm. The optical zone (102) includes a third annular region (103c) having additional refractive power, an on-axis curvature center, and a width of 0.8 mm. The optical zone (102) includes a fourth annular region (103d) that is a distance-correcting zone, has an on-axis curvature center, and a width of 0.925 mm.

Description

Technical Field

[0001] This disclosure relates to contact lenses. In particular (but not exclusively), this disclosure relates to contact lenses for slowing the progression of myopia, and to methods of manufacturing such lenses. Background Technology

[0002] Many people (including children and adults) need ophthalmic lenses to correct myopia (short-sightedness). Uncorrected myopia focuses incoming light from distant objects in front of the retina. Therefore, the light diverges towards the retina and defocuses after reaching it. Regular ophthalmic lenses used to correct myopia (such as spectacle lenses and contact lenses) shift the focus onto the retina. Spectacle lenses shift the focus by causing incoming light from distant objects to diverge before reaching the eye. Contact lenses, when in contact with the eye, shift the focus by reducing the convergence of incoming light from distant objects.

[0003] Decades ago, it was proposed that undercorrection (i.e., moving the focus towards but not fully onto the retina) could slow or prevent the progression of myopia in children or young adults. This method can be described as providing "myopic defocus." However, this method inevitably leads to decreased distance vision compared to the vision obtained with lenses that fully correct myopia. Furthermore, the effectiveness of undercorrection in controlling developing myopia is now questionable, as this method focuses light from distant objects in front of the retina. However, since myopia is considered to develop due to prolonged viewing of near objects, undercorrection may not affect the retinal image of near objects or provide "myopic defocus" to stop eye growth. Newer methods for correcting myopia include providing lenses with one or more areas of full correction that provide distance vision and one or more areas of undercorrection or intentionally induced myopic defocus. This method has been shown to prevent or slow the development or progression of myopia in children or young adults while providing good distance vision.

[0004] In cases where a lens has areas that provide defocus, the area providing full correction for distance vision is typically referred to as the basic refractive power area, while the area providing undercorrection or intentionally induced myopic defocus is typically referred to as the myopic defocus area or the additional refractive power area (because its refractive power is more positive or less negative than that of the hyperopic correction area). The surface of the additional refractive power area (usually the anterior surface) has a smaller radius of curvature than that of the hyperopic refractive power area, and therefore provides the eye with more positive or less negative refractive power. The additional refractive power area is designed to focus incoming parallel light (i.e., light from infinity or essentially the far field of the optical system) in front of the retina (i.e., closer to the lens) within the eye, while the hyperopic refractive power area is designed to focus light and form an image at the retina (i.e., further away from the lens).

[0005] One known type of contact lens that reduces the progression of myopia is a bifocal contact lens available under the name MISIGHT (CooperVision). This bifocal lens differs from bifocal or multifocal contact lenses configured to improve vision in presbyopic individuals in that it is configured with specific optical dimensions so that the adaptable person can simultaneously use hyperopic correction (i.e., basic refractive power) to focus the image on or near the retina when viewing both distant and near objects. Compared to lenses without a treatment zone, the treatment zone of a bifocal lens with additional refractive power will always focus light further forward, thus providing a myopicly defocused image at both distant and near viewing distances.

[0006] Further lenses have been developed for treating myopia, designed to eliminate halos observed around the image at the focal distance. In these lenses, the annular region is configured so that a single on-axis image is not formed in front of the retina, thereby preventing this image from being used to avoid the need for the eye to adapt to near objects. Specifically, the far point light source is imaged from the annular region to the annular focal line at the near additional refractive power focal plane, thus preventing the formation of a useful image at this plane. A second advantage of this type of lens is that the light rays forming the annular image overlap upon reaching the retina, resulting in a smaller size of the blurred area and eliminating the peripheral "halo" on the retina. Summary of the Invention

[0007] According to a first aspect, this disclosure provides a contact lens including a lens body. The lens body includes an optical zone, a peripheral zone surrounding the optical zone, and a lens edge surrounding the peripheral zone. The optical zone includes a central region having curvature centered on an optical axis. The central region has a distance-correcting refractive power and a chord diameter of 2.7 mm ± 0.04 mm. The optical zone includes a first annular region surrounding the central region. The first annular region is a myopic defocusing region having a more positive refractive power than the central region. The first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. The optical zone includes a second annular region surrounding the first annular region. The second annular region is a distance-correcting region and has curvature centered on the optical axis. The second annular region has a radial width of 0.6 mm ± 0.01 mm. The optical zone includes a third annular region surrounding the second annular region. The third annular region is a myopic defocusing region having a more positive refractive power than the central region. The third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm. The central region includes a fourth annular region surrounding the fourth annular region. The fourth annular region is a distance correction region with a curvature centered on the optical axis. The fourth annular region has a radial width of 0.925 mm ± 0.015 mm.

[0008] According to a second aspect, this disclosure provides a method for manufacturing a contact lens. The contact lens may be the same as the contact lens according to the first aspect. The method may include forming a contact lens. The contact lens includes a lens body. The lens body includes an optical region, a peripheral region surrounding the optical region, and a lens edge surrounding the peripheral region. The optical region includes a central region having curvature centered on an optical axis. The central region has a distance-correcting refractive power and a chord diameter of 2.7 mm ± 0.04 mm. The optical region includes a first annular region surrounding the central region. The first annular region is a myopic defocusing region having a more positive refractive power than the central region. The first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. The optical region includes a second annular region surrounding the first annular region. The second annular region is a distance-correcting region and has curvature centered on the optical axis. The second annular region has a radial width of 0.6 mm ± 0.01 mm. The optical region includes a third annular region surrounding the second annular region. The third annular region is a myopic defocusing region with a more positive refractive power than the central region. The third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm. The optical region includes a fourth annular region surrounding the fourth annular region. The fourth annular region is a distance correction region with a curvature centered on the optical axis. The fourth annular region has a radial width of 0.925 mm ± 0.015 mm.

[0009] According to a third aspect, this disclosure provides a method for slowing the progression of myopia. The method includes providing a myopic individual with contact lenses capable of adapting to different near distances. The lenses may be those according to the first aspect.

[0010] Of course, it should be understood that features described with respect to one aspect of this disclosure may be incorporated into other aspects of this disclosure. For example, the methods of this disclosure may be incorporated into features described with reference to the apparatus of this disclosure, and vice versa. Attached Figure Description

[0011] Embodiments of the present invention will now be described by way of example only with reference to the accompanying schematic diagrams, wherein:

[0012] Figure 1A This is a top view of a known contact lens used to prevent myopia;

[0013] Figure 1B yes Figure 1A A side view of a contact lens.

[0014] Figure 2A When the lens is positioned on the eye Figure 1A A schematic diagram of the light rays leading to lens B;

[0015] Figure 2B illustrates the formation of a distant point source when the lens is positioned on the eye. Figure 1A The light pattern at the near-focal surface of the lens;

[0016] Figure 2C shows the formation of a distant point source when the lens is positioned on the eye. Figure 1A The light pattern at the remote focal plane of the lens;

[0017] Figure 3A This is a top view of a contact lens according to an embodiment of the present disclosure;

[0018] Figure 3B yes Figure 3A A side view of a contact lens;

[0019] Figure 4 It is a drawing showing the proportions of light reaching the retina of the lens wearer, the light being focused by myopia (i.e., focused at a point in front of the retina), by hyperopia (i.e. focused at a point behind the retina), and by normal vision (i.e. focused at the retina of the lens wearer) for various lenses used to treat myopia.

[0020] Figure 5 It showcases untreated eyes, lens wearers wearing known lenses designed to slow myopia progression, and those wearing... Figure 3A and 3B A drawing showing the changes in the axial growth of the lens over time as the wearer experiences these changes.

[0021] Figure 6 It showcases lens wearers and the wearing of known lenses designed to slow the progression of myopia. Figure 3A and 3B A graph showing the change in refractive error of the lens wearer over time; and

[0022] Figure 7 This is a flowchart illustrating a method for manufacturing a lens according to an embodiment of the present disclosure. Detailed Implementation

[0023] According to a first aspect, this disclosure provides a contact lens including a lens body. The lens body includes an optical zone, a peripheral zone surrounding the optical zone, and a lens edge surrounding the peripheral zone. The optical zone includes a central region having curvature centered on an optical axis. The central region has a distance-correcting refractive power and a chord diameter of 2.7 mm ± 0.04 mm. The optical zone includes a first annular region surrounding the central region. The first annular region is a myopic defocusing region having a more positive refractive power than the central region. The first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. The optical zone includes a second annular region surrounding the first annular region. The second annular region is a distance-correcting region and has curvature centered on the optical axis. The second annular region has a radial width of 0.6 mm ± 0.01 mm. The optical zone includes a third annular region surrounding the second annular region. The third annular region is a myopic defocusing region having a more positive refractive power than the central region. The third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm. The central region includes a fourth annular region surrounding the fourth annular region. The fourth annular region is a distance correction region with a curvature centered on the optical axis. The fourth annular region has a radial width of 0.925 mm ± 0.015 mm.

[0024] The contact lens according to this disclosure includes a lens body. The lens body may be a polymeric unit formed by the polymerization of a contact lens formulation. Preferably, the lens body is a hydrogel material or a silicone hydrogel material, such that the contact lens is a hydrogel contact lens or a silicone hydrogel contact lens.

[0025] The lens body has a front surface, which is either the front surface that does not contact the wearer's eye or the front-facing surface when the contact lens is worn by the wearer. The lens body also has a back surface, which is either the back surface that contacts the wearer's eye or the back-facing surface when the contact lens is worn by the wearer.

[0026] The lens body includes an optical zone. The optical zone may be substantially circular. The optical zone may be oval. The optical zone encompasses the portion of the lens that performs optical functions. The optical zone is configured to be positioned above the pupil of the eye during use. The optical zone may have a diameter from 7.0 mm to 9.0 mm; for example, the optical zone may have a diameter of approximately 8.75 mm. Where diameter values ​​are described and / or claimed herein, unless otherwise stated, the diameter should be understood as the chord diameter. Where diameter values ​​for circular, oval, or elliptical regions are described and / or claimed herein, unless otherwise stated, the diameter should be understood as the average diameter of this region (i.e., the average of all diameter values ​​measured around the circumference of this region).

[0027] For the eyeglasses according to this disclosure, the optical zone includes a central region and concentric annular regions extending radially outward from said central region. The optical zone is surrounded by a peripheral region. The peripheral region surrounds the outermost annular region. The peripheral region is not part of the optical zone, but is located outside the optical zone and above the iris when the lens is worn, and it provides mechanical functions, such as increasing the size of the lens to make it easier to handle, providing counterweight to prevent lens rotation (in lenses requiring counterweight, such as toroidal lenses), and / or providing a shaped area to improve the comfort of the lens wearer. Typically, a boundary can be seen at the interface between the optical zone and the peripheral region. This boundary defines the periphery of the optical zone. The lens body has a lens edge that surrounds the peripheral region. The lens edge is the interface between the front and rear surfaces of the lens body. The peripheral region may extend to the edge of the contact lens.

[0028] The contact lens according to this disclosure may include a weight for orienting the lens when positioned on the wearer's eye. The lens, with the weight incorporated into the contact lens, will rotate to a predetermined rest angle under the action of the wearer's eyelids when placed on the wearer's eye; for example, the weight may be a wedge and the rotation may be generated by the movement of the eyelids on the wedge. It is well known in the art that weighted contact lenses orient contact lenses; for example, weighted toric contact lenses orient the lens such that the orthogonal cylindrical correction provided by the lens is correctly aligned for astigmatism in the wearer's eye. In this embodiment, the optical region of the contact lens may include a toric optical region. For example, the anterior surface of the optical region of the contact lens may include a central region and an annular region as described above, and the posterior surface of the optical region may be annular and designed to provide astigmatism correction.

[0029] Contact lenses can be basically round in shape and have a diameter ranging from about 6 mm to about 20 mm.

[0030] The first optical axis can be along the center line of the lens. The first optical axis can be defined with reference to the far point source. Light from the far point source on the optical axis of the lens (which may be referred to as the on-axis far point source below) will be focused onto the optical axis of the lens.

[0031] The central region of the optical zone has curvature centered on the optical axis. This can be referred to as the on-axis center of curvature. The curvature can be the curvature of the front surface of the lens body, the curvature of the rear surface of the lens body, or the curvature resulting from a combination of the curvatures of the front and rear surfaces of the lens body.

[0032] As a result of the on-axis center of curvature, the central region focuses light from a distant object on the optical axis onto a point on the optical axis at the focal plane. As used herein, the term focal plane does not refer to a physical surface, but rather to the surface that can be drawn by light from a distant object to the point that will be focused. This surface is also referred to as the image plane (even if it can be curved) or the image shell. The eye focuses light onto the curved retina, and in a perfectly focused eye, the curvature of the image shell would match the curvature of the retina. Therefore, the eye does not focus light onto a flat mathematical plane. However, in the relevant field, the curvature of the retina is generally referred to as a plane.

[0033] The central region can be substantially circular. The central region has a diameter of 2.7 mm ± 0.04 mm. The central region can be substantially oval. The central region can be substantially elliptical (i.e., substantially oval in shape, with two vertical lines of symmetry along its major and minor axes).

[0034] It has been found that, compared to known lenses used to control myopia, this relatively small central area diameter provides the wearer with an increased treatment area within the pupil and more myopic defocus toward the center of the lens rather than the periphery, while preserving sufficient vision and adaptation for the wearer.

[0035] The lens described herein has a central region and concentric annular regions. The central region has curvature centered on the optical axis (i.e., on-axis center of curvature), and the concentric annular regions also have curvature centered on the optical axis. The refractive power of the central region herein may refer to distance-corrected refractive power. Light from a far point source on the optical axis of the lens (hereinafter referred to as the on-axis far point source) passing through the central region or concentric annular regions will be focused onto the optical axis of the lens.

[0036] The nominal refractive power of the central region will correspond to the refractive power marked on the contact lens package (although it may not actually be the same value). This will be the average refractive power obtained across the central region in the radial and circumferential directions. The measured refractive power of the central region is the directly measured average refractive power obtained across the central region in the radial and circumferential directions. This may differ from the nominal refractive power.

[0037] The distance correction power can range from +0.5 diopter (D) to -20.00 D, preferably between +0.5 D and -15.0 D, and more preferably between +0.5 D and -6.0 D. The distance correction power corresponds to the refractive power required to correct the wearer's distance vision.

[0038] The optical zone includes the first annular region surrounding the central area.

[0039] For the lens described herein, the first annular region has a curvature centered on the optical axis. This curvature can be the curvature of the front surface of the lens body, the rear surface of the lens body, or a combination of the front and rear surfaces of the lens body.

[0040] The first annular zone is a myopic astigmatic zone with a more positive or less negative distance-corrected refractive power than the central zone. The refractive power of the first myopic astigmatic zone can be +2.0 D more positive than the distance-corrected refractive power of the central zone. The refractive power of the first myopic astigmatic zone can be +3.0 D more positive than the distance-corrected refractive power of the central zone. For example, if the central zone has a distance-corrected refractive power of -3.0 D, then the refractive power of the first annular zone can be 0.0 D. In the following text, the difference in refractive power between the first annular zone and the central zone may be referred to as additional refractive power. The refractive power of the first annular zone will be the sum of the distance-corrected refractive power and the additional refractive power. For example, for a lens with a distance-corrected refractive power of -4.0 D and an additional refractive power of +3.0 D, the refractive power of the first annular zone will be -1.0 D.

[0041] The distance-corrected refractive power of the central region can be negative, and the first annular region can have less negative refractive power than the basal region, or the first annular region can have positive refractive power. Considering a lens positioned on the cornea, if the refractive power of the first annular region is less negative than the distance-corrected refractive power, then the focal plane of the first annular region will be more forward in the eye than the distal focal plane. Considering a lens not positioned on the cornea, if the refractive power of the first annular region is positive, then the focal plane of the first annular region will be on the (image) side of the lens opposite the focal plane of the central region (which will be the virtual focal plane on the object side of the lens); if the refractive power of the first annular region is negative (but less negative than the distance-corrected refractive power), then the virtual focal plane of the first annular region will be further away from the lens than the virtual focal plane of the central region.

[0042] The distance-correcting refractive power in the central region can be positive, and the first annular region can have a more positive refractive power than the distance-correcting refractive power. In this case, the focal plane of the first annular region will be closer to the lens than the focal plane of the central region. Light passing through the first annular region will not form an on-axis image on the wearer's retina unless the wearer uses the eye's natural accommodation to focus nearby objects.

[0043] It should be understood that similar considerations apply to the second, third, and fourth annular zones, where the second and fourth annular zones have less positive or more negative distance-corrected refractive power than the first annular zone, and the third annular zone has more positive or less negative distance-corrected refractive power than the central zone.

[0044] The first annular region encloses the central region. The first annular region extends radially outward from the periphery of the central region. The first annular region may be substantially circular, substantially oval, or substantially elliptical in shape. The first annular region may completely surround the central region. The first annular region may partially surround the central region. The first annular region may be adjacent to the central region.

[0045] The fusion region may be located between the central region and the first annular region. The fusion region should substantially not image the optics provided by the central region and the first annular region. The fusion region may have a radial width between 0.03 mm and 0.08 mm. The fusion region may have a radial width of 0.05 mm or less, although it may also be as wide as 0.2 mm, or in some embodiments as wide as 0.5 mm. The first annular region has a radial width of 0.7 mm ± 0.01 mm.

[0046] The optical region includes a second annular region that surrounds the first annular region.

[0047] The second annular region has a curvature centered on the optical axis. This curvature can be the curvature of the front surface of the lens body, the rear surface of the lens body, or a combination of the front and rear surfaces of the lens body.

[0048] The second annular zone is the distance correction zone. The refractive power of the second annular zone is less positive or more negative than that of the first annular zone. The refractive power of the second annular zone may be the same as that of the central zone. Alternatively, the refractive power of the second annular zone may differ from that of the central zone. The refractive power of the second annular zone may be more positive or less negative than that of the central zone, but less positive or more negative than that of the first annular zone. The refractive power of the second annular zone may be less positive or more negative than that of the central zone. The refractive power of the second annular zone may be between +0.5 D and -20.0 D, preferably between +0.5 D and -6.0 D.

[0049] The second annular region surrounds the first annular region. The second annular region extends radially outward from the periphery of the first annular region. The second annular region may have a substantially circular, substantially oval, or substantially elliptical shape. The second annular region may completely surround the first annular region. The second annular region may partially surround the first annular region. The second annular region may be adjacent to the first annular region.

[0050] The fusion region may be located between the first annular region and the second annular region. The fusion region should substantially not affect the optics provided by the first and second annular regions. The fusion region may have a radial width between 0.03 mm and 0.08 mm. The fusion region may have a radial width of 0.05 mm or less, although it may also be as wide as 0.2 mm, or in some embodiments as wide as 0.5 mm. The second annular region has a radial width of 0.6 mm ± 0.01 mm.

[0051] The optical zone includes a third annular area surrounding the central region.

[0052] The third annular region has a curvature centered on the optical axis. This curvature can be the curvature of the front surface of the lens body, the rear surface of the lens body, or a combination of the front and rear surfaces of the lens body.

[0053] The third ring zone is a myopic defocusing zone with more positive refractive power than the central zone. The refractive power of the third ring zone can be the same as that of the first ring zone. The refractive power of the third ring zone can differ from that of the first ring zone. The refractive power of the third ring zone can be more positive or less negative than that of the first ring zone. The refractive power of the third ring zone can be less positive or more negative than that of the first ring zone, but will be more positive or less negative than the distance-corrected refractive power of the central zone. The refractive power of the third ring zone can be +3.0 D more positive than the distance-corrected refractive power of the central zone. The refractive power of the third ring zone can be between +2 D and +8 D more positive than the distance-corrected refractive power of the central zone.

[0054] The third annular region surrounds the second annular region. The third annular region extends radially outward from the periphery of the second annular region. The third annular region may have a substantially circular, substantially oval, or substantially elliptical shape. The third annular region may completely surround the second annular region. The third annular region may partially surround the second annular region. The third annular region may be adjacent to the second annular region.

[0055] The fusion region may be located between the second and third annular regions. The fusion region should substantially not affect the optics provided by the second and third annular regions. The fusion region may have a radial width between 0.03 mm and 0.08 mm. The fusion region may have a radial width of 0.05 mm or less, although it may also be as wide as 0.2 mm, or in some embodiments as wide as 0.5 mm. The third annular region has a radial width of 0.8 mm ± 0.015 mm.

[0056] The optical region includes the fourth annular region that surrounds the third annular region.

[0057] The fourth annular region has a curvature centered on the optical axis. This curvature can be the curvature of the front surface of the lens body, the rear surface of the lens body, or a combination of the front and rear surfaces of the lens body.

[0058] The fourth ring zone is the distance correction zone. The refractive power of the fourth ring zone will be less positive or more negative than that of the first ring zone. The refractive power of the fourth ring zone may be the same as the distance correction refractive power of the central zone. Alternatively, the refractive power of the fourth ring zone may differ from the distance correction refractive power of the central zone. The refractive power of the fourth ring zone may be more positive or less negative than the distance correction refractive power of the central zone, but less positive or more negative than that of the first ring zone. The refractive power of the fourth ring zone may be less positive or more negative than the distance correction refractive power of the central zone.

[0059] A fourth annular region surrounds the third annular region. The fourth annular region extends radially outward from the periphery of the third annular region. The fourth annular region may have a substantially circular or substantially elliptical shape. It may completely surround the third annular region. It may partially surround the third annular region. The fourth annular region may be adjacent to the third annular region. A fusion region may be disposed between the third and fourth annular regions. The fusion region should substantially not affect the optics provided by the third and fourth annular regions. The fusion region may have a radial width between 0.03 mm and 0.08 mm. The fusion region may have a radial width of 0.05 mm or less, although it may also be as wide as 0.2 mm, or in some embodiments as wide as 0.5 mm. The fourth annular region has a radial width of 0.925 mm ± 0.015 mm.

[0060] It has been found that the radial widths of the first, second, third, and fourth annular zones described and claimed herein, combined with a central zone having a diameter of 2.7 mm, provide a signal that is more effective than prior art coaxial myopic defocus contact lenses in slowing myopia progression. The claimed central zone diameter and the radial widths of the first, second, third, and fourth annular zones described and claimed herein provide relatively more myopic defocus compared to prior art coaxial myopic defocus contact lenses, and provide more myopic defocus towards the center of the lens rather than towards the periphery, while still providing the wearer with sufficiently clear distance vision, and providing a consistent amount of myopic defocus regardless of the wearer's pupil size.

[0061] Preferably, the lens body comprises a hydrogel material or a silicone hydrogel material. As understood in the field of contact lenses, a hydrogel is a material that maintains water in equilibrium and does not contain silicone chemicals. A silicone hydrogel is a hydrogel containing silicone chemicals. As described in the context of this disclosure, the hydrogel material and the silicone hydrogel material have an equilibrium water content (EWC) of at least 10% to about 90% (wt / wt). The hydrogel material or the silicone hydrogel material may have an EWC of about 30% to about 70% (wt / wt). Examples of suitable lens fittings include those with the following US Adopted Names (USAN): metafilcon A, ocufilcon A, ocufilcon B, ocufilcon C, ocufilcon D, omafilcon A, omafilcon B, comfilcon A, enfilcon A, stenfilcon A, fanfilcon A, etafilcon A, senofilcon A, senofilcon B, senofilcon C, narafilcon A, narafilcon B, balafilcon A, samfilcon A, lotrafilcon A, lotrafilcon B, somofilcon A, riofilcon A, delefilcon A, verofilcon A, kalifilcon A, and similar.

[0062] The lens body according to this disclosure can be a polymerization reaction product of a diluent-free contact lens formulation. For example, the contact lens formulation of the present invention may not contain organic solvents to help reduce phase separation of different chemical compounds in the formulation or to aid in the handling of the contact lens during its manufacture. The diluent is a non-reactive additive not incorporated into the contact lens body. Typically, the diluent used in the manufacture of contact lenses can be extracted from the contact lens body after polymerization, for example, by washing with a 50:50 ethanol:water solution. The diluent-free formulation typically contains less than 3% (wt / wt), especially less than 1% (wt / wt) of diluent. The formulation advantageously contains less than 3% (wt / wt) of organic solvent, especially less than 1% of organic solvent.

[0063] According to this disclosure, the lens body may be a polymer reaction product of a contact lens formulation containing at least seven different chemical compounds without a diluent.

[0064] The formulation may contain compounds of Formula 1.

[0065]

[0066] Where m is an integer from 3 to 10, n is an integer from 0 to 10, and R 1 It is an alkyl group having 1 to 4 carbon atoms, R 2 It is hydrogen or methyl, and R 3 It is hydrogen or methyl. In the contact lenses of this invention, the compound of formula 1 can be a siloxane monomer, wherein R 1 It is butyl, R 2 It is hydrogen, R 3 It is a methyl group, m is 4 and n is 1.

[0067] Contact lens formulations may also contain compounds of formula 2.

[0068]

[0069] Wherein R1 is selected from hydrogen or methyl; R2 is selected from hydrogen or C1-4 hydrocarbon group; m represents an integer from 0 to 10; n represents an integer from 4 to about 15; a represents an integer from 60 to 100; b represents an integer from 1 to 10; and the configuration of the siloxane units includes random configuration. A specific example of a compound of Formula 2 is a siloxane macromonomer, wherein R1 and R2 are methyl, m is 0, n represents an integer from about 5 to about 10, a represents an integer from about 70 to about 90, and b represents an integer from 1 to about 10, for example from 4 to 8; this siloxane monomer has a molecular weight of about 8,000 to about 16,000 Daltons.

[0070] Contact lens formulations may also contain the following compounds:

[0071] Compound of Formula 3

[0072] ;

[0073] Compound of Formula 4

[0074] ;

[0075] Compound of Formula 5

[0076] ;

[0077] Compound of Formula 6

[0078] ;and

[0079] Compound of Formula 7

[0080] .

[0081] In the compound of formula 1, R 1 It can be butyl, R 2 It can be hydrogen, R 3R1 and R2 can be methyl, m can be 4, and n can be 1; and in the compound of formula 2, R1 and R2 can be methyl, m can be 0, n can represent an integer from about 5 to about 10, a can represent an integer from about 70 to about 90, and b can represent an integer from 1 to about 10, for example from 4 to 8, and the compound of formula 2 can have a molecular weight from about 8,000 to about 16,000 Daltons.

[0082] The contact lenses of the present invention may further comprise an ultraviolet (UV) filter or absorber. The UV filter may comprise at least one benzotriazole-containing UV filter. The UV filter may be methyl 2-[3-(2H-benzotriazolyl)-4-hydroxyphenyl]methacrylate. The UV filter may be a compound containing benzophenone. The contact lenses may comprise a combination of a benzotriazole-containing UV filter and a benzophenone-containing UV filter.

[0083] Contact lens formulations may also contain 2-(allyloxy)ethanol, 1,4-bis[4-(2-methacryloyloxyethyl)phenylamino]-9,10-anthraquinone and triphenylphosphine.

[0084] Contact lens formulations may not contain phosphocholine monomers.

[0085] In the manufacture of contact lenses, it may be necessary to control the dimensions of the lens edge. The shape of the lens edge region can affect the comfort of the contact lens. Therefore, in the contact lenses of the present invention, the lens edge has an edge thickness that contributes to a comfortable wearing experience. To help ensure the desired quality control, the edge thickness is measured at a specified distance from the actual lens edge. Thus, as an example, when measured at a radial distance of 0.10 mm from the lens edge (i.e., from the lens edge towards the geometric center of the contact lens body), the contact lenses of the present invention can have an edge thickness of less than 0.10 mm. At a radial distance of 0.10 mm from the lens edge, the lens edge thickness can be less than 0.08 mm. At a radial distance of 0.07 mm from the lens edge, the lens edge thickness can be less than 0.08 mm. Furthermore, at a radial distance of 0.07 mm from the lens edge, the lens can have a lens edge thickness of less than 0.05 mm.

[0086] The contact lens of the present invention has a center thickness. The center thickness is measured at the geometric center of the contact lens or at the geometric center of the optical zone. The center thickness can be determined using conventional techniques, such as visually measuring the distance from the front surface to the rear surface of the lens body at the geometric center of the lens. Alternatively, the center thickness can be determined based on design specification targets. The contact lens of the present invention can have a center thickness from 0.06 mm to 0.20 mm, for example, when visually determined on a slice lens.

[0087] Furthermore, the contact lens of the present invention may have a peripheral interface thickness. The peripheral interface corresponds to the interface between the peripheral region and the ramp surface extending from the lens edge to the peripheral region. In the present case, the peripheral interface is located approximately 0.5 mm to 0.9 mm from the lens edge. The contact lens of the present invention may have a peripheral interface thickness of 0.15 mm to 0.25 mm. The peripheral interface thickness and the center thickness can be important features in the optical design of the contact lens. For example, one can set the peripheral interface thickness to a target value and the center thickness to a target value, and then adjust the curvature of the anterior surface of the contact lens to provide the desired refractive power at those two fixed points.

[0088] In the contact lenses of this invention, the rate of change of refractive power between any two zones within the optical zone can be relatively steep. When measured at a resolution of less than 0.09 mm, the rate of change of refractive power at the junction between two adjacent zones (e.g., the central region and the first myopic defocus zone) can be at least 6 D / mm. The rate of change of refractive power can be determined using optical examination instruments available from Optocraft or Lambda-XOphthalmics. Examples include SHS wavefront sensors and NIMO wavefront sensors.

[0089] The contact lens of this invention may have a central region free of defocus. In other words, the central region consists of a single effective refractive power to correct the wearer's distance vision, wherein the refractive power is substantially constant across the entire central region (including the geometric center of the central region).

[0090] The contact lenses of this invention may not contain microlenses or may have smaller microlenses provided on the surface of the contact lens. Therefore, the annular region can be considered as a continuous ring providing myopic defocus or distance correction.

[0091] The present invention also provides a method of manufacturing a contact lens. The method includes forming a contact lens, wherein the lens includes a lens body, the lens body including an optical region, a peripheral region surrounding the optical region, and a lens edge surrounding the peripheral region. The optical region includes a central region having a curvature centered on an optical axis. The central region has a distance-correcting refractive power and a chord diameter of 2.7 mm ± 0.04 mm. The optical region includes a first annular region surrounding the central region. The first annular region is a myopic defocusing region having a more positive refractive power than the central region. The first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. The optical region includes a second annular region surrounding the first annular region. The second annular region is a distance-correcting region and has a curvature centered on the optical axis. The second annular region has a radial width of 0.6 mm ± 0.01 mm. The optical region includes a third annular region surrounding the second annular region. The third annular region is a myopic defocusing region having a more positive refractive power than the central region. The third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm. The central region includes a fourth annular region surrounding the third annular region. The fourth annular region is a distance correction region with a curvature centered on the optical axis. The fourth annular region has a radial width of 0.925 mm ± 0.015 mm.

[0092] The lens may include any of the features described in the first aspect above.

[0093] Contact lenses can be molded contact lenses. Lenses can be formed by casting molding, rotational casting molding, or turning processes, or combinations thereof. As understood by those skilled in the art, casting molding refers to molding a lens by placing lens forming material between a concave mold part having a concave lens component forming surface and a convex mold part having a convex lens component forming surface.

[0094] The method may include the following steps: placing a contact lens preparation onto a concave molding surface of a first contact lens mold component, wherein the concave molding surface includes a molding region corresponding to an optical zone; placing a second contact lens mold component in contact with the first contact lens mold component to form a contact lens mold assembly; polymerizing the contact lens preparation in the contact lens mold assembly to form a polymerized contact lens; removing the polymerized contact lens from the contact lens mold assembly to produce a separate contact lens; and encapsulating the separate contact lens in a contact lens package. Optionally, a solvent and / or water may be used to wash the polymerized lens to remove unreacted chemical compounds. This washing step may be performed simultaneously, for example, with the step of removing the polymerized contact lens from the mold assembly. Alternatively or additionally, the washing step may be performed on the separate lens after the removal step.

[0095] In a third aspect of this disclosure, a method of using the contact lenses described herein is also provided. The method can effectively slow the progression of refractive errors, such as slowing the progression of myopia. When the lenses of the present invention are used to slow the progression of myopia, the method includes the step of providing the contact lenses to a wearer whose eyes are adapted to different near distances (e.g., in the range of about 15 cm to about 40 cm). The method may include the step of providing ophthalmic lenses to a person aged about 5 to about 25 years. The provision may be performed by an eye care practitioner, such as an optician or optometrist. Alternatively, the provision may be performed by a lens dispenser arranged for delivering ophthalmic lenses to the lens wearer.

[0096] Figure 1A and 1B Schematic top and side views of known lenses used to slow myopia progression (e.g., myopia control) are shown. Lens 1 includes an optical zone 2 that substantially covers the pupil and a peripheral zone 4 located above the iris. The peripheral zone 4 provides mechanical functions, including increasing the size of the lens to make it easier to handle, providing weighting in some instances to prevent lens 1 from rotating (e.g., in toric lenses), and providing a shaped area to improve wearer comfort. Optical zone 2 provides the optical functions of lens 1 and includes an annular zone 3 and a central zone 5. The central zone 5 is a distance correction zone. The central zone has a diameter of approximately 3.35 mm. The annular zone 3 is a myopic defocus zone and has a greater refractive power than the central zone 5. The annular zone 3 has an additional refractive power of +2.0 D compared to the central zone.

[0097] For simple purposes, Figure 1A and 1B The lens 1 shown has a single central region 5 and a single annular region 3. It should be understood that similar known lenses contain multiple concentric annular myopic defocus regions, each with a refractive power greater than that of the central region. Additional annular myopic defocus regions can be separated by distance correction regions that provide the same refractive power as the central region.

[0098] Figure 2A This demonstrates when lens 1 is positioned on the eye. Figures 1A to 1BA schematic diagram of how a known lens 1 focuses light. The focal point 11 of the annular region 3 is located on the near focal plane 13, and the focal point 15 of the central region 5 is located on the far focal plane 17, which is further away from the rear surface of the lens 1. The central region 5 has a curvature centered on the optical axis 19. The annular region 3 has a greater curvature than the central region 5 (and therefore a smaller radius of curvature). The curvature of the annular region 3 is also centered on the optical axis 19. Therefore, the focal point 11 of the annular region 3 and the focal point 15 of the central region 5 share a common optical axis 19. As shown in Figures 2B and 2C, for an on-axis point source in the far field, the light focused by the central region 5 forms a focal point 15 at the far focal plane 17, but the light focused by the central region 5 also produces an unfocused blurry spot 27 at the near focal plane 13. Similarly, the light focused by the annular region 3 forms a focal point 11 at the near focal plane 13, but the light focused by the annular region 3 diverges after the near focal plane 13, and the diverged light produces an unfocused ring 25 at the far focal plane 17. As discussed above, the unfocused annular image 25 can cause the wearer of the lens 1 to see a “halo” around the focused distance image.

[0099] Figure 3A A schematic top view of a contact lens 101 according to an embodiment of the present disclosure is shown. Figure 3B yes Figure 3A The diagram shows a schematic side view of lens 101. Lens 101 includes a lens body 106. Lens body 106 includes an optical zone 102 that substantially covers the pupil, and a peripheral zone 104 that surrounds the optical zone 102 and is located above the iris. The peripheral zone 104 provides mechanical functions, including increasing the size of the lens to make lens 101 easier to handle, and in some instances providing counterweight to prevent lens 101 from rotating (e.g., in toric lenses), and providing a shaped area to improve the wearer's comfort. Lens edge 108 surrounds the peripheral zone. Optical zone 102 provides the optical functions of lens 101. Optical zone 102 includes a central region 105. The central region 105 is a distance correction zone and has a curvature centered on the optical axis 119, formed by... Figure 3A The letter "X" and Figure 3B The dotted line indicates the focal point. The distance-correcting refractive power of central region 105 is selected to correct the patient's distance vision, and in this example, lens 101 has a refractive power of -3.0D. The focal point of central region 105 is at the distant focal plane (not shown). The central region has a diameter of 2.7 mm ± 0.04 mm, and is composed of... Figure 3A The letter "A" indicates this.

[0100] The first annular region 103a surrounds the central region 105. The first annular region 103a is a myopic defocus region. The first annular region 103a has a curvature centered on the same optical axis 119 as the central region 105, i.e., they share a common optical axis 119. The first annular region 103a has a curvature greater than that of the central region 105, i.e., smaller than the radius of curvature of the central region 105, and provides a refractive power +3.0 D greater than that of the central region 105. In other words, the additional refractive power of the first annular region 103a is +3.0 D, and in this example, the refractive power of the first annular region 103a is 0.0 D. The focal point of the first annular region 103a is located on a near focal plane (not shown), which is closer to the posterior surface of the lens 101 than a far focal plane (not shown). The first annular region has a radial width of 0.7 mm ± 0.01 mm. Figure 3A The letter "B" indicates this.

[0101] The second annular region 103b surrounds the first annular region 103a. The second annular region 103b is a distance correction region. The second annular region 103b has a curvature centered on the same optical axis 119 as the central region 105 and the first annular region 103a, i.e., they share a common optical axis 119. The second annular region 103b has the same curvature as the central region 105, i.e., the same radius of curvature as the central region 105, and in this example, provides a distance correction refractive power of -3.0 D. The focal point of the second annular region 103b is located at the remote focal plane (not shown). The second annular region has a radial width of 0.6 mm ± 0.01 mm, formed by... Figure 3A The letter "C" indicates this.

[0102] The third annular region 103c surrounds the second annular region 103b. The third annular region 103c is a myopic defocus region. The third annular region 103c has a curvature centered on the same optical axis 119 as the central region 105 and the first annular region 103a, i.e., they share a common optical axis 119. The third annular region 103c has the same curvature as the first annular region 103a, i.e., the same radius of curvature as the first annular region 103a. This curvature provides a refractive power +3.0 D greater than that of the central region 105. In other words, the additional refractive power of the third annular region 103c is +3.0 D, and therefore the refractive power of the first annular region 103c is 0.0 D. The focal point of the first annular region 103a is located on the near focal plane (not shown), which is closer to the posterior surface of the lens 101 than the far focal plane (not shown). The third annular region 103c has a radial width of 0.8 mm ± 0.015 mm. Figure 3A The letter "D" indicates this.

[0103] The fourth annular region 103d surrounds the third annular region 103c. The fourth annular region is the distance correction region. The fourth annular region 103d has a curvature centered on the same optical axis 119 as the central region 105 and the first annular region 103a; that is, they share a common optical axis 119. The fourth annular region 103d has the same curvature as the central region 105, that is, the same radius of curvature as the central region 105, and provides a distance correction refractive power of -3.0 D. The focal point of the fourth annular region 103b is located at the remote focal plane (not shown). The fourth annular region 103d has a radial width of 0.925 mm ± 0.015 mm, formed by... Figure 3A The letter "E" indicates this.

[0104] Compared with known lenses used to slow the progression of myopia (e.g.) Figure 1A Compared to the lens 1 shown and described in 3C and the related description above, Figure 3A and 3B The lens 101 shown and described above has a relatively small central area 105 diameter, a relatively wide myopic defocus area, and a relatively narrow distance correction area.

[0105] Compared to known lenses used to slow the progression of myopia, when lenses according to this disclosure (e.g.) Figure 3A and 3B When lens 101 is worn by the wearer, a relatively large proportion of the wearer's pupil will be covered by the myopic defocus zones 103a and 103c, and more myopic defocus will be provided towards the center of the lens compared to the periphery. This has been found to be effective in slowing the progression of myopia.

[0106] Figure 4 It is a drawing 300 showing the proportion of light reaching the retina of the lens wearer, the light being focused by myopia (i.e., focused at a point in front of the retina), by hyperopia (i.e. focused at a point behind the retina), and by emmetropia (i.e. focused at the retina of the lens wearer) for the treatment of myopia with three different lenses (lens A, lens B, and lens C). Figure 4 The proportions shown are for lens wearers with fully dilated pupils. Lens A is a known lens for treating myopia. The central region provides distance correction and has a diameter of 3.35 mm, as described above. The lens comprises two concentric annular regions, each providing an additional +2.0 D of refractive power. The two concentric annular regions are separated by the annular region providing distance correction. Lens B is similar to Lens A, having a central region providing distance correction and a diameter of 3.35 mm. The lens comprises two concentric annular regions, and in this case, each annular region provides an additional +3.0 D of refractive power. The two concentric annular regions are separated by the annular region providing distance correction. Lens C is... Figure 3A and 3B The lens 101 shown and described herein is a lens according to this disclosure. The central region provides distance-correcting refractive power and has a central region diameter of 2.7 mm.

[0107] Circular data points 301 (lens A), 303 (lens B), and 305 (lens C) show the proportion of light reaching the wearer's retina when the lens is used to view a distant target at a distance of 6m. Triangular data points 307 (lens A), 309 (lens B), and 311 (lens C) show the proportion of light reaching the wearer's retina when the lens is used to view a near target at a distance of 25cm.

[0108] like Figure 4 As shown, compared to lenses A and B (which have a larger diameter of 3.35 mm), lens C (which is the lens according to this disclosure and has a central area diameter of 2.7 mm) results in a larger proportion of the light reaching the wearer's retina being myopic defocus light. This is the case when the wearer is viewing a distant target (circle symbol) and a near target (triangle symbol).

[0109] Reducing the diameter of the central area from 3.35 mm to 2.7 mm results in a relatively large increase in the proportion of myopic astigmatic light reaching the wearer's retina (as illustrated by comparing lens A and lens B with lens C). This is the case when the wearer is viewing distant objects (circles) and near objects (triangles). In contrast, increasing the additional refractive power from +2.0 D to +3.0 D results in a relatively small increase in the proportion of myopic astigmatic light reaching the wearer's retina. This can be seen by comparing lens A with lens B. Again, this is the case when the wearer is viewing distant objects (circles) and near objects (triangles).

[0110] According to the lens of this disclosure (e.g.) Figure 4 The lens C shown in the image (which has a relatively small central area diameter of 2.7 mm, a relatively wide myopic defocus zone, and a relatively narrow distance correction zone) provides a relatively large proportion of myopic defocus light at the wearer's retina, and a relatively large proportion of myopic defocus light toward the central area of ​​the retina rather than the peripheral area. This has been found to be particularly effective in slowing the progression of myopia, as described below. Figure 5 and 6 As shown in the image.

[0111] Figure 5 This showcases different lenses designed to slow the progression of myopia (lens A, lens B, and lens C, as mentioned above). Figure 4A drawing 400 showing the axial eye growth (i.e., the progression of myopia) of a lens wearer over time as described.

[0112] During the first 12 months of the study, all participants except those in the untreated eye group wore lens A. After 12 months, all participants wearing lens A were randomly assigned to lens A, lens B, or lens C.

[0113] like Figure 5 As shown, after 24 months, wearers of lens A or lens B (indicated by curves 403 and 405, respectively) exhibited 50% or 0.32 mm slower axial eye growth compared to untreated lens wearers (shown by curve 407). After 24 months, wearers of lens C (curve 401) (which is a lens with a relatively small central area diameter of 2.7 mm according to this disclosure) exhibited an average reduction of 0.11 mm in axial growth (indicated by curve 401) compared to wearers of lens A (curve 403) or lens B (curve 405). In contrast, wearers of lens B (curve 405) (which has the same central area diameter of 3.35 mm as lens A (curve 403) but with a higher additional refractive power of +3.0D) did not exhibit significantly slower axial growth over the 24-month period compared to lens A (403). This instruction indicates that lenses according to this disclosure (e.g., lens C, which has a relatively small central area diameter of 2.7 mm) are particularly effective in slowing axial growth and thus slowing the progression of myopia.

[0114] Figure 6 This showcases different lenses designed to slow the progression of myopia (lens A, lens B, and lens C, as mentioned above). Figure 4 The graph 500 shows the cumulative changes in refractive error over time for lens wearers (as described).

[0115] During the first 12 months of the study, all participants except those in the untreated eye group wore lens A. After 12 months, lens A wearers were randomly assigned to lens A, lens B, or lens C.

[0116] like Figure 6As demonstrated, after 24 months, compared to wearers of lens A (indicated by curve 503) or lens B (indicated by curve 505), wearers of lens C (which is a lens with a relatively small central area diameter of 2.7 mm according to the present disclosure) exhibited significantly smaller changes in refractive error (indicated by curve 501). Compared to lens A, wearers of lens B (curve 505) (which has the same central area diameter of 3.35 mm as lens A but with a higher additional refractive power of +3.0 D) exhibited smaller changes in refractive error than wearers of lens A (curve 503), but larger changes in refractive error than wearers of lens C (curve 501). This indicates that lenses with a relatively small central area diameter of 2.7 mm according to the present disclosure (e.g., lens C (curve 501)) are particularly effective in slowing myopia progression.

[0117] Figure 7This is a flowchart illustrating a method 1000 for manufacturing a contact lens according to an embodiment of the present disclosure. In a first step 1001, a contact lens preparation is placed onto a concave molding surface of a first contact lens mold component, wherein the concave molding surface includes molding areas corresponding to an optical zone and a peripheral zone. In a second step 1003, a second contact lens mold component is placed in contact with the first contact lens mold component to form a contact lens mold assembly. In a third step 1005, the contact lens preparation is polymerized in the contact lens assembly to form a polymerized contact lens. In a fourth step 1007, the polymerized contact lens is removed from the contact lens mold assembly to produce a separate contact lens. The resulting contact lens is a lens body. The lens body includes an optical zone, a peripheral zone surrounding the optical zone, and a lens edge surrounding the peripheral zone. The optical zone includes a central region having a curvature centered on the optical axis. The central region has a distance corrective refractive power and a chord diameter of 2.7 mm ± 0.04 mm. The optical zone includes a first annular region surrounding the central region. The first annular region is a myopic defocusing region with a refractive power correction of +3.0D compared to the central region. The first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. The optical region includes a second annular region surrounding the first annular region. The second annular region is a distance correction region and also has a curvature centered on the optical axis. The second annular region has a radial width of 0.6 mm ± 0.01 mm. The optical region includes a third annular region surrounding the second annular region. The third annular region is a myopic defocusing region with a refractive power correction of more than the central region. The third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm. The optical region includes a fourth annular region surrounding the fourth annular region. The fourth annular region is a distance correction region with a curvature centered on the optical axis. The fourth annular region has a radial width of 0.925 mm ± 0.015 mm.

[0118] Although the invention has been described and illustrated with reference to specific embodiments, those skilled in the art will understand that the invention is adaptable to many different variations not specifically set forth herein. Specific possible variations are described herein by way of example only.

[0119] In exemplary embodiments of this disclosure, the second and fourth annular regions provide the same distance-correcting refractive power as the central region. In other embodiments, the second and fourth annular regions may each provide different distance-correcting refractive powers, and these refractive powers may differ from the distance-correcting refractive power of the central region. In exemplary embodiments of this disclosure, the first and third annular regions provide the same additional refractive power with more positive or less negative distance-correcting refractive power than the central region. In other embodiments, the third annular region may provide different additional refractive power to the first annular region.

[0120] Wherein, in the foregoing description, references are made to elements or components having known, obvious, or foreseeable equivalents, such equivalents are incorporated herein as individually stated. The true scope of the invention should be determined with reference to the claims, which should be construed as covering any such equivalents. The reader will also understand that elements or features of the invention described as preferred, advantageous, convenient, or similar are optional and do not limit the scope of the independent claims. Furthermore, it should be understood that while such optional elements or features may have feasible benefits in some embodiments of the invention, they may not be desired and therefore may not be present in other embodiments.

Claims

1. A contact lens, the lens comprising a lens body, and the lens body including an optical region, a peripheral region surrounding the optical region, and a lens edge surrounding the peripheral region, the optical region comprising: A central region having a curvature centered on the optical axis, wherein the central region has a distance-correcting refractive power and a chord diameter of 2.7 mm ± 0.04 mm; and A first annular region surrounds the central region, wherein the first annular region is a myopic defocusing region having a more positive refractive power than the central region, wherein the first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. A second annular region surrounds the first annular region, wherein the second annular region is a distance correction region and has a curvature centered on the optical axis, wherein the second annular region has a radial width of 0.6 mm ± 0.01 mm. and A third annular region surrounds the second annular region, wherein the third annular region is a myopic defocusing region having a more positive refractive power than the central region, wherein the third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm. and A fourth annular region surrounds the third annular region, wherein the fourth annular region is a distance correction region with curvature centered on the first optical axis, and wherein the fourth annular region has a radial width of 0.925 mm ± 0.15 mm.

2. The contact lens of claim 1, wherein the first annular region has a refractive power that is +3.0 D greater than that of the central region.

3. The contact lens of claim 1, wherein the first annular region has a refractive power that is +2.0 D greater than that of the central region.

4. The contact lens according to claim 1 or claim 2, wherein the third annular region has a refractive power that is +3.0 D greater than that of the central region.

5. The contact lens according to any of the preceding claims, wherein the third annular region has a more positive refractive power than the distance-correcting refractive power of the central region, and is different from the refractive power of the first annular region.

6. The contact lens according to any one of claims 1 to 3, wherein the third annular region has a refractive power that is +2.0 D greater than that of the central region.

7. The contact lens according to any of the preceding claims, wherein the distance correction refractive power is between +0.5 D and -20.0 D.

8. The contact lens of claim 7, wherein the distance correction refractive power is between +0.5 D and -6.0 D.

9. The contact lens according to any of the preceding claims, wherein the second annular region has the same refractive power as the central region in terms of distance correction.

10. The contact lens according to any of the preceding claims, wherein the fourth annular region has the same refractive power as the central region in terms of distance correction.

11. The contact lens according to any of the preceding claims, wherein the lens body comprises a hydrogel material or a silicone hydrogel material.

12. The contact lens according to any of the preceding claims, wherein the lens edge has an edge thickness of less than 0.10 mm measured at a radial distance of 0.10 mm from the lens edge.

13. The contact lens of claim 12, wherein the edge thickness of the lens is less than 0.08 mm at a radial distance of 0.10 mm from the edge of the lens.

14. The contact lens according to any of the preceding claims, wherein the edge thickness of the lens is less than 0.08 mm at a radial distance of 0.07 mm from the edge of the lens.

15. The contact lens of claim 14, wherein the edge thickness of the lens is less than 0.05 mm at a radial distance of 0.07 mm from the edge of the lens.

16. The contact lens according to any of the preceding claims, wherein the contact lens has a center thickness from 0.06 mm to 0.20 mm.

17. The contact lens according to any of the preceding claims, wherein the contact lens has a peripheral interface at a distance of about 0.5 mm to 0.9 mm from the edge of the lens, the peripheral interface having a thickness of from 0.15 mm to 0.25 mm.

18. The contact lens according to any of the preceding claims, wherein, when measured at a resolution of less than 0.09 mm, the rate of change of refractive power at the junction between any two adjacent zones of the optical zone is at least 6 D / mm.

19. A method of manufacturing a contact lens according to any preceding claim, the method comprising: A contact lens is formed, wherein the lens includes a lens body, the lens body comprising an optical region, a peripheral region surrounding the optical region, and a lens edge surrounding the peripheral region, the optical region including: A central region having a curvature centered on the optical axis, wherein the central region has a distance-correcting refractive power and a chord diameter of 2.7 mm ± 0.04 mm; and A first annular region surrounds the central region, wherein the first annular region is a myopic defocusing region having a more positive refractive power than the central region, wherein the first annular region has a curvature centered on the optical axis and a radial width of 0.7 mm ± 0.01 mm. A second annular region surrounds the first annular region, wherein the second annular region is a distance correction region and has a curvature centered on the optical axis, wherein the second annular region has a radial width of 0.6 mm ± 0.01 mm; and A third annular region surrounds the second annular region, wherein the third annular region is a myopic defocusing region having a more positive refractive power than the central region, wherein the third annular region has a curvature centered on the optical axis and a radial width of 0.8 mm ± 0.015 mm; and A fourth annular region surrounds the third annular region, wherein the fourth annular region is a distance correction region with curvature centered on the first optical axis, and wherein the fourth annular region has a radial width of 0.925 mm ± 0.15 mm.

20. A method of manufacturing a contact lens according to claim 19, wherein a turning process is used to form the lens.

21. A method of manufacturing a contact lens according to claim 19, comprising: The contact lens preparation is placed on the concave molding surface of the first contact lens mold component, wherein the concave molding surface includes a molding area corresponding to the optical zone; The second contact lens mold component is placed in contact with the first contact lens mold component to form a contact lens mold assembly; The contact lens formulation is polymerized in the contact lens assembly to form a polymeric contact lens; Remove the polymeric contact lens from the contact lens mold assembly to produce a separate contact lens; and The separate contact lens is encapsulated in a contact lens package.

22. A method for slowing the progression of myopia, comprising: Provide contact lenses according to any one of claims 1 to 18 to nearsighted individuals who can adapt to different near distances.

Images