A composition for dynamic repair of sensitive skin, its preparation method and application

Abstract

This invention discloses a composition for dynamic repair of sensitive skin, its preparation method, and its application, belonging to the field of cosmetic technology. The composition, by weight, comprises 3.5-7.5 parts of active repair components, 3.0-6.5 parts of intelligent responsive carriers, and 86.0-93.5 parts of cosmetically acceptable matrix. The active repair components are extracts of purslane, rhodiola rosea, and Panax notoginseng. The intelligent responsive carriers consist of thermosensitive hydrogels and pH-responsive microspheres, each loading the corresponding active ingredients. This invention achieves multi-target dynamic response to the core causes of sensitive skin through the synergistic effect of dual intelligent carriers, overcoming the shortcomings of existing products such as static repair, lack of environmental stimulation response, and low bioavailability of active ingredients. It achieves a dynamic adaptation between gentle repair under normal conditions and enhanced protection during stimulation, with synergistic enhancement of active ingredients. The preparation process is gentle and easily industrialized, and it can be used to prepare various sensitive skin repair cosmetics with excellent safety.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition that provides dynamic repair for sensitive skin, its preparation method, and its application. Background Technology

[0002] Sensitive skin (SS) is a hyperreactive state of the skin, specifically referring to a skin condition that is prone to subjective symptoms such as burning, stinging, itching, and tightness when stimulated by external physical, chemical, or psychological factors, with or without objective signs such as erythema, scaling, and telangiectasia.

[0003] Modern medical research indicates that the core pathogenesis of sensitive skin is a vicious cycle of "damaged skin barrier function - neurosensory hyperresponsiveness - activation of immune inflammatory response": As the outermost protective barrier of the human body, damage to the lipid bilayer structure of the stratum corneum allows external stimuli to easily penetrate the skin, activating keratinocytes, mast cells, and sensory nerve endings, releasing neuropeptides and inflammatory factors (such as IL-1α, IL-6, TNF-α, etc.). This exacerbates the damage to the skin barrier and induces neurovascular hyperresponsiveness, further lowering the skin's tolerance threshold to stimuli, ultimately forming a vicious cycle of "external stimulation - inflammation outbreak - worsened barrier damage - increased susceptibility to irritation." Among these, ultraviolet radiation, dry environment, air pollutants, and sudden temperature changes are the four core external triggers for acute exacerbations of sensitive skin symptoms. Approximately 85% of people with sensitive skin report that their symptoms significantly worsen under sunlight, during seasonal dryness, in smoggy weather, or in environments with alternating hot and cold temperatures.

[0004] Currently, the core research and development of repair products for sensitive skin on the market mainly focuses on three directions: first, replenishing skin barrier lipids, such as ceramides, cholesterol, and fatty acids, to repair the stratum corneum structure through exogenous replenishment; second, adding anti-inflammatory and soothing ingredients, such as panthenol, dipotassium glycyrrhizate, and plant extracts, to inhibit inflammatory responses and alleviate subjective discomfort; and third, adding moisturizing ingredients to increase skin hydration and improve dryness and tightness. However, existing products generally suffer from a core technological deficiency: they are all static repair models, only capable of basic repair under normal conditions, lacking the ability to respond to environmental stimuli, and unable to dynamically adjust the release rate and intensity of active ingredients according to the skin's environmental state and inflammation level.

[0005] Specifically, the shortcomings of existing technologies are mainly reflected in the following aspects: First, it cannot achieve a dynamic adaptation of "mild repair under normal conditions + enhanced protection during irritation." Existing products have a fixed release rate of active ingredients. Under normal conditions, to ensure gentleness, the amount of active ingredients added is limited, resulting in insufficient repair effects. Increasing the concentration of active ingredients, however, can easily cause additional irritation to already fragile and sensitive skin. Furthermore, in the absence of external stimuli, high concentrations of active ingredients can lead to decreased skin tolerance, exacerbating sensitivity. When external stimuli occur, the fixed release rate of active ingredients cannot quickly reach an effective concentration, failing to promptly block the inflammatory cascade, leading to an acute worsening of sensitivity symptoms. The repair effect is greatly affected by environmental factors.

[0006] Secondly, they lack multi-target environmental response capabilities and cannot cover the core triggering factors of sensitive skin. The few existing skincare products with responsive properties can only achieve a single stimulus response, such as a single pH response or a single temperature response. They cannot simultaneously respond to multiple core triggering factors of sensitive skin, such as ultraviolet rays, dryness, pollutants, temperature changes, and pH changes caused by inflammation, and cannot comprehensively block the vicious cycle of "stimulation-inflammation-barrier damage".

[0007] Third, the compatibility between active ingredients and response carriers is poor, resulting in low bioavailability. Current technologies often mix multiple active ingredients and load them onto a single carrier. This fails to match the appropriate response carrier to the target site and onset time of different active ingredients, leading to premature release, degradation, and inactivation of the active ingredients, preventing them from reaching the correct effective concentration at the right time and site. For example, anti-inflammatory ingredients require rapid targeted release when inflammation occurs, while barrier repair ingredients require long-term locked release when the skin is dry or the temperature is high. A single carrier cannot simultaneously meet these two different release requirements, thus failing to fully realize the synergistic effect of the active ingredients.

[0008] Fourth, the lack of scientific formulation design results in insufficient synergistic repair effects. The plant extract formulations of existing sensitive skin products are mostly simple ingredient stacking, without precise multi-target formulations targeting the pathogenesis of sensitive skin. They cannot achieve synergistic effects of anti-inflammation, barrier repair, and antioxidant detoxification, and often only relieve surface symptoms, failing to fundamentally improve the hyperreactive state of sensitive skin, leading to easy relapse after discontinuation.

[0009] Therefore, developing a dynamic repair composition for sensitive skin that has multi-environmental stimulus response capabilities, can achieve dynamic adaptation of "normal repair + enhanced protection during stimulation", synergistic effect of active ingredients, high bioavailability, and excellent safety is a technical problem that urgently needs to be solved in this field. It is of great significance for improving the skin condition of people with sensitive skin and enhancing the technical level of sensitive skin repair products. Summary of the Invention

[0010] To address the shortcomings of existing sensitive skin repair products, such as lack of environmental responsiveness, inability to dynamically adapt to repair, low bioavailability of active ingredients, poor synergistic effects, and high susceptibility to environmental influences, this invention aims to provide a composition that achieves dynamic repair of sensitive skin. Through precise formulation of active ingredients and synergy with dual intelligent response carriers, it achieves multi-target dynamic response to five core triggers of sensitive skin: ultraviolet radiation, dryness and hypoxia, pollutants, temperature changes, and pH changes due to inflammation. This breaks the vicious cycle of "stimulation-inflammation-barrier damage." The invention also provides a method for preparing and applying this composition.

[0011] The objective of this invention can be achieved through the following technical solutions: A composition for dynamic repair of sensitive skin, comprising, by weight, 3.5-7.5 parts of active repairing components, 3.0-6.5 parts of intelligent responsive carrier, and 86.0-93.5 parts of cosmetically acceptable matrix; The active repairing component consists of 1.5-3.0 parts of purslane extract, 1.0-2.5 parts of rhodiola rosea extract, and 1.0-2.0 parts of Panax notoginseng extract; The intelligent responsive carrier is composed of 2.0-4.0 parts of temperature-sensitive hydrogel and 1.0-2.5 parts of pH-responsive microspheres; The thermosensitive hydrogel is Poloxamer 407, and the pH-responsive microspheres are pH-sensitive microspheres based on calcium alginate.

[0012] Furthermore, the purslane extract is prepared by water extraction and alcohol precipitation of the whole purslane herb, wherein the mass fraction of total flavonoids is ≥8%; the rhodiola rosea extract is prepared by alcohol extraction of rhodiola rosea rhizome, wherein the mass fraction of rhodioloside is ≥3%; and the Panax notoginseng extract is prepared by alcohol extraction of Panax notoginseng main root, wherein the mass fraction of total Panax notoginseng saponins is ≥10%.

[0013] Furthermore, by weight, the active repairing component consists of 2.0 parts of purslane extract, 1.5 parts of rhodiola rosea extract, and 1.0 part of Panax notoginseng extract.

[0014] Furthermore, by weight, the smart response carrier consists of 3.0 parts of temperature-sensitive hydrogel and 2.0 parts of pH-responsive microspheres.

[0015] Furthermore, the pH-responsive microspheres are calcium alginate microspheres loaded with purslane extract and Panax notoginseng extract, and the particle size of the microspheres is 10-50 μm.

[0016] Furthermore, the thermosensitive hydrogel is a poloxamer 407 hydrogel loaded with Rhodiola rosea extract, and the gelation temperature of the hydrogel is 32-34℃.

[0017] Further, the acceptable base of the cosmetic includes one or more of moisturizers, chelating agents, soothing agents, preservatives, and deionized water; by weight, the moisturizer is 5.0-15.0 parts, the chelating agent is 0.05-0.2 parts, the soothing agent is 0.1-0.5 parts, the preservative is 0.1-1.0 parts, and the balance is deionized water.

[0018] Preferably, the moisturizer is one or more of glycerin, propylene glycol, 1,3-propanediol, sodium hyaluronate, and hydrolyzed sodium hyaluronate; the chelating agent is disodium EDTA; the soothing agent is one or more of allantoin and panthenol; and the preservative is one or more of p-hydroxyacetophenone and 1,2-hexanediol.

[0019] This invention also provides a method for preparing the above-mentioned composition with dynamic repair effects on sensitive skin, comprising the following steps: S1 Preparation of pH-responsive microspheres loaded with active ingredients: Prepared using an emulsification-ionic crosslinking method, specifically as follows: S1-1 Prepare a sodium alginate aqueous solution with a mass fraction of 1.5-2.5%, add the prescribed amounts of purslane extract and Panax notoginseng extract, stir at room temperature until completely dissolved, homogeneously disperse, and obtain the aqueous phase; S1-2 Preparation of the oil phase: Add Span 80 to liquid paraffin and stir until completely dissolved to obtain the oil phase, wherein the mass fraction of Span 80 is 3-5%; S1-3 The aqueous phase is slowly added dropwise to the oil phase at a flow rate of 1-2 mL / min. The volume ratio of the aqueous phase to the oil phase is 1:3-5. During the dropwise addition, the high-speed emulsification is maintained at 8000-12000 rpm. After the dropwise addition is completed, emulsification is continued for 10-20 min to obtain a W / O type emulsion. S1-4 Add a 5-10% (w / w) calcium chloride aqueous solution to the emulsion, stir and crosslink for 30-60 min, centrifuge, wash 2-3 times each with petroleum ether and anhydrous ethanol, and freeze dry under vacuum to obtain pH-responsive microspheres loaded with active ingredients. S2 Preparation of thermosensitive hydrogel loaded with active ingredients: Add the prescribed amount of poloxamer 407 to deionized water at 4℃, stir until completely dissolved, prepare a poloxamer stock solution with a mass fraction of 18-22%, add the prescribed amount of Rhodiola rosea extract, stir until completely dissolved, and let stand at 4℃ for 12-24 hours to defoam, and obtain thermosensitive hydrogel loaded with active ingredients. Preparation of S3 composition: S3-1 Add the water-soluble components of a cosmetically acceptable matrix to deionized water, heat to 40-45℃, and stir until completely dissolved to obtain an aqueous matrix; S3-2 Cool the aqueous matrix to room temperature, add the pH-responsive microspheres prepared in step S1, and stir to disperse evenly; S3-3 Add the thermosensitive hydrogel prepared in step S2 to the system, stir at low speed to mix evenly, and degas under vacuum to obtain the composition that has the effect of dynamic repair of sensitive skin.

[0020] Furthermore, in steps S1-4, the amount of calcium chloride aqueous solution added is 10-20% of the volume of sodium alginate aqueous solution.

[0021] The present invention also provides the application of the above-mentioned composition with the dynamic repair effect on sensitive skin in the preparation of sensitive skin repair cosmetics.

[0022] Furthermore, the dosage form of the cosmetic is any one of serum, toner, lotion, cream, or gel.

[0023] The beneficial effects of this invention are: 1. This invention achieves a multi-dimensional dynamic response to the five core triggers of sensitive skin through the synergistic use of a temperature-sensitive hydrogel and a pH-responsive microsphere dual-intelligent carrier, combined with the stimulation-responsive characteristics of the active ingredients: UV stimulation response: Flavonoids in purslane extract can significantly enhance anti-inflammatory and antioxidant activity by activating the Nrf2 signaling pathway under UV irradiation. At the same time, UV irradiation causes an increase in skin temperature, triggering the sol-gel transition of the thermosensitive hydrogel, locking in active ingredients, prolonging the duration of action, and achieving enhanced anti-inflammatory protection under UV stimulation. Dryness / Hypoxia Stimulation Response: Rhodioloside in Rhodiola rosea extract can significantly upregulate the expression of filaggrin, natildin, and tight junction protein in keratinocytes under dry and hypoxia conditions, thereby strengthening the skin barrier function. At the same time, in dry environments, the transepidermal water loss of the skin is accelerated and the skin temperature fluctuation is increased, triggering the gelation of thermosensitive hydrogels, forming a moisturizing protective film on the skin surface, reducing water loss, and achieving barrier repair and strengthening under dry conditions. Pollutant irritation response: The total saponins of Panax notoginseng extract can exert antioxidant and detoxification effects on harmful substances such as PM2.5 and polycyclic aromatic hydrocarbons in air pollutants, inhibit the generation of reactive oxygen species and inflammatory responses induced by pollutants. At the same time, pollutant irritation can induce mild skin inflammation and lower the local pH value, triggering the structural disintegration of pH-responsive microspheres, which rapidly releases Panax notoginseng saponins and purslane flavonoids, thereby achieving enhanced antioxidant detoxification and anti-inflammatory effects under pollutant irritation. Temperature Response: The gelation temperature of Poloxamer 407 thermosensitive hydrogel is 32-34℃, which matches the normal skin surface temperature. Under normal conditions, it is in a low-viscosity sol state with good spreadability and can slowly release rhodioloside to achieve basic barrier repair under normal conditions. When the skin temperature rises (such as due to UV radiation, inflammation and fever, or alternating hot and cold stimulation), it quickly transforms into a gel state, forming a dense protective film on the skin surface. On the one hand, it locks in the active ingredients and prolongs the action time; on the other hand, it blocks the transdermal penetration of external irritants, achieving enhanced protection and repair when the temperature rises. Inflammation pH Response: The calcium alginate pH-responsive microspheres are structurally stable at normal skin pH (around 5.5), releasing only a small amount of active ingredients slowly to ensure gentleness under normal conditions. When skin inflammation occurs, the local pH drops to 4.0-5.0, the calcium cross-linked structure of the calcium alginate microspheres disintegrates, rapidly releasing the loaded purslane flavonoids and notoginseng saponins, which target the inflamed area, quickly inhibit the inflammatory response, block the inflammatory cascade, and achieve targeted and precise repair of the inflamed area.

[0024] Through the above five dynamic response mechanisms, the composition of the present invention achieves the following: Under normal conditions, it gently and slowly releases active ingredients to perform basic barrier repair and anti-inflammatory stabilization, avoiding stimulation of sensitive skin by high concentrations of active ingredients; when external stimulation occurs or inflammation occurs, it rapidly and targetedly releases active ingredients to enhance anti-inflammatory, barrier repair, and antioxidant effects, and promptly interrupts the vicious cycle of "stimulation-inflammation-barrier damage," fundamentally solving the core contradiction of existing products that are "stimulating under normal conditions but ineffective when stimulated."

[0025] 2. This invention targets the core pathogenesis of sensitive skin, precisely selecting three active ingredients—purslane extract, rhodiola rosea extract, and Panax notoginseng extract—and scientifically combining them to achieve a three-dimensional synergistic effect of anti-inflammation, barrier repair, and antioxidant detoxification, thereby fundamentally improving the hyperreactive state of sensitive skin. Purslane extract: The core active ingredient is flavonoids, which have significant anti-inflammatory and soothing effects. It can inhibit the release of inflammatory mediators such as NO, IL-6, and TNF-α in LPS-induced RAW264.7 macrophages, and quickly relieve the burning, stinging, and redness symptoms of sensitive skin. It also has a certain antioxidant capacity and is the core anti-inflammatory and soothing ingredient in this invention. Rhodiola rosea extract: The core active ingredient is rhodioloside, which has excellent barrier repair and anti-hypoxia capabilities. It can significantly upregulate the expression of barrier-related proteins in keratinocytes, repair damaged stratum corneum structure, reduce transepidermal water loss, and inhibit the release of neuropeptides, thereby reducing the skin's neuroreactivity. It is the core component for barrier repair in this invention. Panax notoginseng extract: The core active ingredient is total saponins of Panax notoginseng, which has powerful antioxidant and detoxifying effects. It can scavenge free radicals, inhibit the generation of reactive oxygen species induced by pollutants, reduce the damage of oxidative stress to the skin, and promote skin microcirculation and accelerate the repair of damaged skin. When combined with purslane extract, it can significantly enhance the anti-inflammatory effect. When combined with Rhodiola rosea extract, it can accelerate barrier repair. It is the core ingredient of this invention for antioxidant detoxification and synergistic effect.

[0026] This invention achieves synergistic effects by precisely optimizing the ratio of three active ingredients: purslane extract provides rapid anti-inflammatory and soothing relief for acute symptoms; rhodiola rosea extract repairs the skin barrier, reducing skin hyperreactivity at its source; and Panax notoginseng extract provides antioxidant and detoxifying effects, blocking damage pathways caused by external stimuli. Each ingredient performs its specific function while working synergistically to comprehensively cover the pathogenesis of sensitive skin. Compared to single-ingredient or simply layered compositions, the repair effect is improved by more than 40%.

[0027] 3. Based on the different target sites and onset times of different active ingredients, this invention matches corresponding intelligent response carriers to achieve precise controlled release of active ingredients: Purslane extract and Panax notoginseng extract, both with anti-inflammatory and antioxidant properties, were loaded into pH-responsive microspheres. The core mechanism for these two ingredients to exert their effects is to target the inflamed area and rapidly reach an effective concentration during inflammation. The pH-responsive microspheres are structurally stable at normal skin pH, releasing only small amounts of the ingredients slowly, ensuring gentleness under normal conditions. When inflammation occurs and the pH decreases, they rapidly disintegrate, releasing the active ingredients and targeting the inflamed area. This avoids premature release and degradation of the active ingredients, significantly improving the bioavailability of the anti-inflammatory components.

[0028] The barrier-repairing Rhodiola rosea extract is loaded into a thermosensitive hydrogel: the core function of rhodioloside is long-lasting repair of the skin barrier, requiring prolonged contact with the skin surface, especially when dry or with elevated skin temperature, necessitating enhanced moisturizing and repair effects. The thermosensitive hydrogel is in a sol state under normal conditions, exhibiting excellent spreadability and allowing for even application to the skin surface, slowly releasing rhodioloside for long-lasting basic repair. When skin temperature rises, it transforms into a gel state, forming a dense protective film on the skin surface, locking in moisture and active ingredients, prolonging the effect of rhodioloside, and simultaneously blocking the penetration of external irritants, significantly enhancing the efficacy of barrier-repairing ingredients.

[0029] By precisely matching the carrier with the active ingredients, this invention solves the problems of premature release, degradation and inactivation, and poor targeting of active ingredients in the prior art, thereby increasing the bioavailability of active ingredients by more than 60% and significantly reducing the irritation of active ingredients to normal skin, thus improving the gentleness and safety of the product.

[0030] 4. In the composition of the present invention, all ingredients are cosmetic raw materials permitted for use in the "Cosmetic Safety Technical Specifications (2022 Edition)", and are free of alcohol, fragrance, pigments, and traditional preservatives. A mild preservative system is adopted, and the controlled release effect of the intelligent carrier avoids direct irritation of the skin by high concentrations of active ingredients. Skin irritation tests have verified that the composition of the present invention is non-irritating and suitable for long-term use by people with sensitive skin.

[0031] 5. The composition of the present invention is adaptable to various cosmetic formulations such as serums, toners, lotions, creams, and gels. The preparation process is simple, the conditions are mild, no special equipment is required, it is suitable for large-scale industrial production, and has excellent industrialization prospects. Detailed Implementation

[0032] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0033] In the following embodiments and comparative examples of the present invention, all raw materials used are cosmetic grade raw materials, wherein: Purslane extract: Prepared by water extraction and alcohol precipitation of whole purslane herb, with a total flavonoid content of 10.2%; Rhodiola rosea extract: prepared by alcohol extraction of Rhodiola rosea rhizome, with a rhodioloside content of 3.5% (w / w). Panax notoginseng extract: prepared by alcohol extraction from the main root of Panax notoginseng, with a total saponin content of 12.6%; Poloxamer 407: BASF, cosmetic grade; Sodium alginate: Cosmetic grade, viscosity 100-200 mPa s; The remaining matrix materials are all commercially available cosmetic-grade conventional raw materials.

[0034] All examples and comparative examples were prepared as serum formulations. The cosmetically acceptable base formulation was uniformly as follows (by weight): 8.0 parts glycerin, 4.0 parts 1,3-propanediol, 0.1 parts sodium hyaluronate, 0.2 parts allantoin, 0.1 parts disodium EDTA, 0.3 parts p-hydroxyacetophenone, 0.5 parts 1,2-hexanediol, with the remainder made up to 100 parts with deionized water.

[0035] Example 1 (Preferred Example) A composition for dynamic repair of sensitive skin, the formula is as follows, by weight: Active repairing ingredients: Purslane extract 2.0 parts, Rhodiola rosea extract 1.5 parts, Panax notoginseng extract 1.0 part Intelligent responsive carrier: 3.0 parts of temperature-sensitive hydrogel and 2.0 parts of pH-responsive microspheres. Acceptable bases for cosmetics: Same as the basic formulations described above Deionized water: Remaining amount, bring to 100 parts The preparation method of the composition in this embodiment includes the following steps: S1 Preparation of pH-responsive microspheres loaded with active ingredients: S1-1 Prepare 100 mL of sodium alginate aqueous solution with a mass fraction of 2.0%, add 20 g of purslane extract and 10 g of Panax notoginseng extract, stir at 300 rpm at room temperature until completely dissolved, homogenize at 3000 rpm for 5 min, disperse evenly, and obtain the aqueous phase; S1-2 Preparation of the oil phase: Add 16g of Span 80 to 400mL of liquid paraffin and stir until completely dissolved to obtain the oil phase; S1-3 The aqueous phase was slowly added dropwise to the oil phase at a flow rate of 1.5 mL / min. During the dropwise addition, high-speed emulsification was maintained at 10,000 rpm. After the dropwise addition was completed, emulsification was continued for 15 min to obtain a W / O type emulsion. S1-4 Add 15 mL of 8% calcium chloride aqueous solution to the emulsion, stir at 300 rpm for 45 min for crosslinking, centrifuge at 4000 rpm for 10 min to separate the microspheres, wash three times each with petroleum ether and anhydrous ethanol, and freeze-dry under vacuum for 24 h to obtain pH-responsive microspheres loaded with active ingredients with a particle size of 20-40 μm. S2 Preparation of thermosensitive hydrogels loaded with active ingredients: Add 30g of poloxamer 407 to 120mL of deionized water at 4℃ and stir until completely dissolved to prepare a poloxamer stock solution with a mass fraction of 20%. Add 15g of Rhodiola rosea extract and stir until completely dissolved. Let stand at 4℃ for 18h to remove bubbles and obtain a thermosensitive hydrogel loaded with active ingredients. The gelation temperature was measured to be 33℃. Preparation of S3 composition: S3-1 Add 80g of glycerin, 40g of 1,3-propanediol, 1g of sodium hyaluronate, 2g of allantoin, 1g of disodium EDTA, 3g of p-hydroxyacetophenone, and 5g of 1,2-hexanediol to 780g of deionized water, heat to 42℃, and stir at 300rpm until completely dissolved to obtain an aqueous matrix. S3-2 Cool the aqueous matrix to room temperature, add 20g of the pH-responsive microspheres prepared in step S1, and stir at 300rpm to disperse evenly; S3-3 Add 30g of the thermosensitive hydrogel prepared in step S2 to the system, stir at 200rpm to mix evenly, degas under vacuum for 5min, and add deionized water to make up to 1000g to obtain the essence composition with the effect of dynamic repair of sensitive skin.

[0036] Example 2 A composition for dynamic repair of sensitive skin, the formula is as follows, by weight: Active repairing ingredients: 1.5 parts purslane extract, 1.0 part rhodiola rosea extract, 1.0 part Panax notoginseng extract. Intelligent responsive carrier: 2.0 parts of temperature-sensitive hydrogel and 1.0 part of pH-responsive microspheres. Acceptable bases for cosmetics: Same as the basic formulations described above Deionized water: Remaining amount, bring to 100 parts The preparation method in this embodiment is completely consistent with that in Example 1, except for the adjustment of the prescription amount.

[0037] Example 3 A composition for dynamic repair of sensitive skin, the formula is as follows, by weight: Active repairing ingredients: Purslane extract 3.0 parts, Rhodiola rosea extract 2.5 parts, Panax notoginseng extract 2.0 parts Intelligent responsive carrier: 4.0 parts of temperature-sensitive hydrogel and 2.5 parts of pH-responsive microspheres. Acceptable bases for cosmetics: Same as the basic formulations described above Deionized water: Remaining amount, bring to 100 parts The preparation method in this embodiment is completely consistent with that in Example 1, except for the adjustment of the prescription amount.

[0038] Comparative Example 1 The only difference between this comparative example and Example 1 is that the purslane extract is removed, and the active repairing components are 1.5 parts of Rhodiola rosea extract and 1.0 part of Panax notoginseng extract. The remaining components, contents, and preparation methods are completely consistent with Example 1.

[0039] Comparative Example 2 The only difference between this comparative example and Example 1 is that the Rhodiola rosea extract is removed, and the active repairing components are 2.0 parts of Portulaca oleracea extract and 1.0 part of Panax notoginseng extract. The remaining components, contents, and preparation methods are completely consistent with Example 1.

[0040] Comparative Example 3 The only difference between this comparative example and Example 1 is that the Panax notoginseng extract is removed, and the active repairing components are 2.0 parts of Portulaca oleracea extract and 1.5 parts of Rhodiola rosea extract. The remaining components, contents, and preparation methods are completely consistent with Example 1.

[0041] Comparative Example 4 The only difference between this comparative example and Example 1 is that the temperature-sensitive hydrogel is removed, and the smart response carrier is only 2.0 parts of pH-responsive microspheres. The other components, contents, and preparation methods are completely consistent with Example 1.

[0042] Comparative Example 5 The only difference between this comparative example and Example 1 is that the pH-responsive microspheres are removed, and the smart response carrier is only 3.0 parts of thermosensitive hydrogel. The other components, contents, and preparation methods are completely consistent with Example 1.

[0043] Comparative Example 6 The only difference between this comparative example and Example 1 is that the thermosensitive hydrogel (poloxam 407) is replaced with an equal mass of ordinary hydrogel matrix carbomer 940. All other components, contents, and preparation methods are completely consistent with Example 1.

[0044] Comparative Example 7 The only difference between this comparative example and Example 1 is that the pH-responsive microspheres are replaced with an equal mass of ordinary sodium alginate microspheres (without calcium ion crosslinking and without pH-responsive characteristics). All other components, contents, and preparation methods are completely consistent with Example 1.

[0045] Comparative Example 8 The only difference between this comparative example and Example 1 is that the total content of the active repairing components remains unchanged (4.5 parts), but the ratio is 0.5 parts of purslane extract, 3.0 parts of rhodiola rosea extract, and 1.0 part of Panax notoginseng extract, which is outside the ratio range limited by this invention. The other components, contents, and preparation methods are completely consistent with Example 1.

[0046] Comparative Example 9 The only difference between this comparative example and Example 1 is that no smart response carrier is added, and the active repair components (2.0 parts of purslane extract, 1.5 parts of rhodiola rosea extract, and 1.0 part of Panax notoginseng extract) are directly added to the matrix. The other components, contents, and preparation methods are completely consistent with those of Example 1.

[0047] Comparative Example 10 This comparative example uses a mainstream commercially available sensitive skin repair serum with core ingredients including ceramides, dipotassium glycyrrhizate, and panthenol. It does not contain a smart response carrier and serves as a positive control sample.

[0048] Comparative Example 11 The only difference between this comparative example and Example 1 is that the three active repair components are replaced with an equal mass (4.5 parts) of a single purslane extract. All other components, contents, and preparation methods are completely consistent with Example 1.

[0049] Comparative Example 12 The only difference between this comparative example and Example 1 is that the purslane extract and Panax notoginseng extract loaded in pH-responsive microspheres are instead loaded in thermosensitive hydrogels; and the Rhodiola rosea extract loaded in thermosensitive hydrogels is instead loaded in pH-responsive microspheres. That is, the matching method between the carrier and the active ingredient is completely reversed. All other components, contents, and preparation methods are completely consistent with Example 1.

[0050] Performance testing I. Samples for testing Composition samples prepared in Examples 1-3 and Comparative Examples 1-12.

[0051] II. Testing Items and Methods 1. In vitro release rate test Four typical skin environments were simulated, and the cumulative release rate of active ingredients in the samples over 24 hours was measured to verify the environmental response characteristics of the compositions. Normal environment: pH 5.5 phosphate-buffered saline (PBS), temperature 32℃, simulating normal skin conditions; UV stimulation / high temperature environment: pH 5.5 PBS, temperature 37℃, simulating the stimulation state of increased skin temperature after UV irradiation; Inflammatory pH environment: pH 4.5 PBS, temperature 32℃, simulating the state of skin inflammation.

[0052] Detection method: The dialysis bag method was used. 2g of sample was placed in a dialysis bag (molecular weight cutoff 8000-14000Da), sealed, and placed in 50mL of the corresponding release medium. The bag was shaken at 32℃ / 37℃ and 100rpm for 24h. The sample was taken after 24h. The total content of total flavonoids, rhodioloside, and total saponins of Panax notoginseng in the release medium was detected by high performance liquid chromatography (HPLC). The cumulative release rate over 24h was calculated. Each sample was tested in triplicate, and the average value was taken.

[0053] 2. Anti-inflammatory efficacy test The RAW264.7 macrophage model was used to detect the inhibition rate of LPS-induced NO release and evaluate the anti-inflammatory efficacy.

[0054] Detection method: RAW264.7 cells were seeded at a density of 1×10^5 cells / well in 96-well plates and cultured for 24 h. Cells were then divided into three groups: a control group, a model group, and a sample group. The control group was treated with complete culture medium, the model group with complete culture medium containing 1 μg / mL LPS, and the sample group with complete culture medium containing 1 μg / mL LPS and 10% sample. Each group had 6 replicates. After 24 h of culture, the NO content in the cell supernatant was measured using the Griess method, and the NO inhibition rate (anti-inflammatory rate) was calculated.

[0055] 3. Barrier repair efficacy testing A 3D reconstructed human epidermal model was used to detect transepidermal water loss (TEWL) values ​​and evaluate the barrier repair efficacy.

[0056] Detection Method: 3D recombinant human epidermal models were divided into a blank group, a damaged group, and a sample group. The blank group received no treatment. The damaged group was treated with 1% SDS solution for 6 hours to construct a barrier damage model. The sample group was treated with 1% SDS for 6 hours, and then 20 mg of sample was applied to the surface, followed by incubation for another 24 hours. The TEWL value of each group was measured using a TEWL analyzer. Each group was measured in triplicate, and the average value was taken. The lower the TEWL value, the better the barrier repair effect.

[0057] 4. Antioxidant efficacy testing The DPPH free radical scavenging rate of the samples was measured to evaluate their antioxidant efficacy.

[0058] Detection method: Take 2 mL of sample solution, add 2 mL of 0.2 mmol / L DPPH ethanol solution, mix well, and let stand in the dark for 30 min. Measure the absorbance A1 at 517 nm. Simultaneously measure the absorbance A2 of the mixture of 2 mL of sample solution and 2 mL of ethanol; and the absorbance A0 of the mixture of 2 mL of DPPH ethanol solution and 2 mL of ethanol. Calculate the DPPH free radical scavenging rate.

[0059] 5. Skin irritation test The irritation of the samples was evaluated using a rabbit ear skin irritation test and according to the Draize scoring system.

[0060] Testing Method: Six healthy New Zealand white rabbits were selected. Twenty-four hours before the experiment, the fur on both sides of the back of the rabbit's ears was shaved, covering an area of ​​approximately 3cm x 3cm. 0.5g of the sample was applied to the left ear, and an equal volume of physiological saline was applied to the right ear as a control. Applications were performed once daily for seven consecutive days. Twenty-four hours after each application, skin reactions were observed and scored according to the Draize rating scale: 0 for no irritation, 1-4 for mild irritation, and 5-8 for moderate to severe irritation.

[0061] 6. Human trial efficacy testing 120 participants aged 18-45 years with sensitive skin, meeting the diagnostic criteria for sensitive skin in the "Chinese Expert Consensus on the Diagnosis and Treatment of Sensitive Skin (2021 Edition)," were recruited and randomly divided into 15 groups of 8 participants each. Each group used samples from Examples 1-3 and Comparative Examples 1-12, respectively, twice daily (morning and evening) for 28 consecutive days. Before and after 28 days of use, the TEWL value and skin redness a* value of the participants' cheeks were measured. Subjective discomfort scores (0-10, where 0 indicates no discomfort and 10 indicates extreme discomfort) for stinging, itching, and burning sensations were also recorded.

[0062] III. Test Results Table 1. Cumulative release rate (%) of active ingredients of each sample under different environments over 24 hours

[0063] Table 2. Results of anti-inflammatory, barrier repair, and antioxidant efficacy tests for each sample.

[0064] Table 3. Draize scores for skin irritation of rabbit ears for each sample.

[0065] Table 4. Efficacy test results of each sample after 28 days of human trial (average value)

[0066] Note: A negative rate of change indicates a decrease in value; the larger the absolute value, the better the improvement.

[0067] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A composition for dynamic repair of sensitive skin, characterized in that, By weight, it includes 3.5-7.5 parts of active repairing components, 3.0-6.5 parts of intelligent response carrier, and 86.0-93.5 parts of cosmetically acceptable matrix; The active repairing component consists of 1.5-3.0 parts of purslane extract, 1.0-2.5 parts of rhodiola rosea extract, and 1.0-2.0 parts of Panax notoginseng extract; The intelligent responsive carrier is composed of 2.0-4.0 parts of temperature-sensitive hydrogel and 1.0-2.5 parts of pH-responsive microspheres; The thermosensitive hydrogel is Poloxamer 407, and the pH-responsive microspheres are pH-sensitive microspheres based on calcium alginate.

2. The composition according to claim 1, characterized in that, The active repairing component, by weight, consists of 2.0 parts of purslane extract, 1.5 parts of rhodiola rosea extract, and 1.0 part of Panax notoginseng extract.

3. The composition according to claim 1, characterized in that, By weight, the smart response carrier consists of 3.0 parts of temperature-sensitive hydrogel and 2.0 parts of pH-responsive microspheres.

4. The composition according to claim 1, characterized in that, The pH-responsive microspheres are calcium alginate microspheres loaded with purslane extract and Panax notoginseng extract, and the particle size of the microspheres is 10-50 μm.

5. The composition according to claim 1, characterized in that, The thermosensitive hydrogel is a poloxamer 407 hydrogel loaded with Rhodiola rosea extract, and the gelation temperature of the hydrogel is 32-34℃.

6. A method for preparing a composition according to any one of claims 1-5 that exhibits dynamic repair effects on sensitive skin, characterized in that, Includes the following steps: S1 Preparation of pH-responsive microspheres loaded with active ingredients: Prepared using an emulsification-ionic crosslinking method, specifically as follows: S1-1 Prepare a sodium alginate aqueous solution with a mass fraction of 1.5-2.5%, add the prescribed amounts of purslane extract and Panax notoginseng extract, stir at room temperature until completely dissolved, homogeneously disperse, and obtain the aqueous phase; S1-2 Preparation of the oil phase: Add Span 80 to liquid paraffin and stir until completely dissolved to obtain the oil phase, wherein the mass fraction of Span 80 is 3-5%; S1-3 The aqueous phase is slowly added dropwise to the oil phase at a flow rate of 1-2 mL / min. The volume ratio of the aqueous phase to the oil phase is 1:3-5. During the dropwise addition, the high-speed emulsification is maintained at 8000-12000 rpm. After the dropwise addition is completed, emulsification is continued for 10-20 min to obtain a W / O type emulsion. S1-4 Add a 5-10% (w / w) calcium chloride aqueous solution to the emulsion, stir and crosslink for 30-60 min, centrifuge, wash 2-3 times each with petroleum ether and anhydrous ethanol, and freeze dry under vacuum to obtain pH-responsive microspheres loaded with active ingredients. S2 Preparation of thermosensitive hydrogel loaded with active ingredients: Add the prescribed amount of poloxamer 407 to deionized water at 4℃, stir until completely dissolved, prepare a poloxamer stock solution with a mass fraction of 18-22%, add the prescribed amount of Rhodiola rosea extract, stir until completely dissolved, and let stand at 4℃ for 12-24 hours to defoam, and obtain thermosensitive hydrogel loaded with active ingredients. Preparation of S3 composition: S3-1 Add the water-soluble components of a cosmetically acceptable matrix to deionized water, heat to 40-45℃, and stir until completely dissolved to obtain an aqueous matrix; S3-2 Cool the aqueous matrix to room temperature, add the pH-responsive microspheres prepared in step S1, and stir to disperse evenly; S3-3 Add the thermosensitive hydrogel prepared in step S2 to the system, stir at low speed to mix evenly, and degas under vacuum to obtain the composition that has the effect of dynamic repair of sensitive skin.

7. The preparation method according to claim 6, characterized in that, In steps S1-4, the amount of calcium chloride aqueous solution added is 10-20% of the volume of sodium alginate aqueous solution.

8. The composition according to any one of claims 1-5, characterized in that, The acceptable base for the cosmetic includes one or more of the following: moisturizer, chelating agent, soothing agent, preservative, and deionized water; by weight, the moisturizer is 5.0-15.0 parts, the chelating agent is 0.05-0.2 parts, the soothing agent is 0.1-0.5 parts, the preservative is 0.1-1.0 parts, and the balance is deionized water.

9. The use of the composition according to any one of claims 1-5 in the preparation of cosmetics for sensitive skin.

10. The application according to claim 9, characterized in that, The cosmetic product can be any one of the following: serum, toner, lotion, cream, or gel.

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