A surface-modified anti-infective orthopedic fixation titanium alloy and its preparation method

Abstract

This invention belongs to the field of titanium alloy preparation, specifically a surface-modified anti-infective orthopedic fixation titanium alloy. It involves implanting copper ions into a Ti6A14V titanium alloy, with the chemical composition being: Cu: 1-5; Ti6A14V titanium alloy: balance. This invention, by implanting copper ions into a metal sheet based on the chemical composition of Ti6A14V titanium alloy, with the Cu ions accounting for 1-5% of the mass, results in a Cu-injected fixation titanium alloy exhibiting a strong bactericidal effect, significantly reducing the incidence of orthopedic implant-related infections.

Description

Technical Field

[0001] This invention relates to the field of orthopedic fixation titanium alloy preparation technology, and in particular to a surface-modified anti-infective orthopedic fixation titanium alloy and its preparation method. Background Technology

[0002] Due to the unique mechanical properties of orthopedic implants, metallic implant materials such as stainless steel, titanium-based alloys, and cobalt-based alloys are widely used in orthopedics, leading to a continuous increase in the use of internal fixation devices and artificial prostheses. Especially in the field of artificial joints, advancements in materials have directly improved postoperative outcomes, accelerated the ingrowth of host bone tissue into the prosthesis, and prolonged the prosthesis's in-situ time, resulting in enhanced postoperative outcomes for orthopedic diseases. Artificial joint replacement has become one of the top ten medical advances of the past decade. Simultaneously, the incidence of implant-related infections in orthopedic surgery is gradually increasing, becoming a very challenging clinical problem. Therefore, we propose a surface-modified, anti-infective titanium alloy for orthopedic fixation and its preparation method. Summary of the Invention

[0003] This invention proposes a surface-modified anti-infective orthopedic fixation titanium alloy and its preparation method to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: A surface-modified, anti-infective orthopedic fixation titanium alloy, based on the chemical composition of Ti6A14V titanium alloy, is implanted with copper ions. Its chemical composition is as follows (by mass percentage): Cu: 1-5; Ti6A14V titanium alloy: Balance.

[0005] Preferably, the Ti6A14V titanium alloy is produced by Shandong Weigao Orthopedic Co., Ltd., and its standard is GB / T 13810-1997.

[0006] Preferred, the chemical composition of Ti6A14V titanium alloy is as follows (by weight percentage): Al: 5.5-6.5; V: 3.5-4.5; Fe: 0.3; C: 0.08; N: 0.05; H: 0.012; O: 0.13; Ti: Balance.

[0007] This invention also proposes a method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy, comprising the following steps: S1: Prepare Ti6A14V titanium alloy rods produced by Shandong Weigao Orthopedics Co., Ltd. as the matrix material; S2: The matrix material in S1 is processed into a metal sheet, and then ground and polished until the surface roughness R of the metal sheet is achieved. <O.1; S3: Copper ions are implanted into the metal sheet processed in S2 using an implantation process to obtain a surface-modified anti-infective orthopedic fixation titanium alloy.

[0008] Preferably, in step S3, copper ions are implanted onto the metal sheet processed in step S2 using a metal vapor vacuum arc ion source high-current metal ion implanter, with an implantation amount of 10... 17 With 10 18 The processing parameters for Cu ion implantation are as follows: (The target amount is ions / cm²) Vacuum degree: 3.0*10 -3 ; Accelerating voltage: 40kV; Negative voltage: 1KV; Trigger voltage: 6kV; Arc voltage: 80V; Average charge state: 2.1; Energy injected: 80keV; Beam current density: 2mA.

[0009] Preferably, in S3, copper ions are implanted onto the metal sheet processed in S2 using a metal solid evaporation / arc ionization process.

[0010] Preferably, in step S3, copper ions are implanted onto the metal sheet processed in step S2 using a pure metal plasma immersion ion implantation process.

[0011] Preferably, in step S3, copper ions are implanted onto the metal sheet processed in step S2 using an ion beam-assisted deposition process.

[0012] Compared with the prior art, the present invention, based on the chemical composition of Ti6A14V titanium alloy, injects copper ions into the metal sheet using an implantation process, wherein the mass percentage of Cu ions is 1-5, so that the fixed metal titanium alloy with injected Cu ions has a strong bactericidal effect, which greatly reduces the incidence of orthopedic implant-related infections. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the metal vapor vacuum arc ion source high-current metal ion implanter used in the preparation method of a surface-modified anti-infective orthopedic fixation titanium alloy proposed in this invention. Figure 2 for Figure 1A schematic diagram of the ion source section of a high-current metal ion implanter using a metal vapor vacuum arc ion source. Figure 3 SEM surface image of a typical titanium alloy; Figure 4 This is a SEM image of a surface-modified anti-infective orthopedic fixation titanium alloy proposed in this invention. Figure 5 This image shows the bactericidal effect of a surface-modified anti-infective orthopedic fixation titanium alloy proposed in this invention. Detailed Implementation

[0014] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0015] Example 1

[0016] like Figure 1-2 A surface-modified anti-infective orthopedic fixation titanium alloy, based on the chemical composition of Ti6A14V titanium alloy, is implanted with copper ions. Its chemical composition is as follows (by mass percentage): Cu: 1-5; Ti6A14V titanium alloy: Balance; Ti6A14V titanium alloy is produced by Shandong Weigao Orthopedic Company, and its standard is GB / T 13810-1997. The chemical composition of Ti6A14V titanium alloy is as follows (by mass percentage): Al: 5.5-6.5; V: 3.5-4.5; Fe: 0.3; C: 0.08; N: 0.05; H: 0.012; O: 0.13; Ti: Balance.

[0017] This embodiment also proposes a method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy, including the following steps: S1: Prepare Ti6A14V titanium alloy rods produced by Shandong Weigao Orthopedics Co., Ltd. as the matrix material; S2: The matrix material in S1 is processed into a metal sheet, and then ground and polished until the surface roughness R of the metal sheet is achieved. <O.1; S3: Copper ions are implanted into the metal sheet processed in S2 using a metal vapor vacuum arc ion source high-current metal ion implanter to obtain a surface-modified, anti-infective orthopedic fixation titanium alloy. The copper ions are implanted into the metal sheet processed in S2 using a metal vapor vacuum arc ion source high-current metal ion implanter at an injection volume of 10... 17 With 10 18 The processing parameters for Cu ion implantation are as follows: (The target amount is ions / cm²) Vacuum degree: 3.0*10 -3 ; Accelerating voltage: 40kV; Negative voltage: 1KV; Trigger voltage: 6kV; Arc voltage: 80V; Average charge state: 2.1; Energy injected: 80keV; Beam current density: 2mA.

[0018] Example 2

[0019] A surface-modified, anti-infective orthopedic fixation titanium alloy, based on the chemical composition of Ti6A14V titanium alloy, is implanted with copper ions. Its chemical composition is as follows (by mass percentage): Cu: 1-5; Ti6A14V titanium alloy: Balance; Ti6A14V titanium alloy is produced by Shandong Weigao Orthopedic Company, and its standard is GB / T 13810-1997. The chemical composition of Ti6A14V titanium alloy is as follows (by mass percentage): Al: 5.5-6.5; V: 3.5-4.5; Fe: 0.3; C: 0.08; N: 0.05; H: 0.012; O: 0.13; Ti: Balance.

[0020] This embodiment also proposes a method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy, including the following steps: S1: Prepare Ti6A14V titanium alloy rods produced by Shandong Weigao Orthopedics Co., Ltd. as the matrix material; S2: The matrix material in S1 is processed into a metal sheet, and then ground and polished until the surface roughness R of the metal sheet is achieved. <O.1; S3: Copper ions are injected into the metal sheet processed in S2 using a metal solid evaporation / arc ionization process to obtain a surface-modified anti-infective orthopedic fixation titanium alloy.

[0021] Example 3

[0022] A surface-modified, anti-infective orthopedic fixation titanium alloy, based on the chemical composition of Ti6A14V titanium alloy, is implanted with copper ions. Its chemical composition is as follows (by mass percentage): Cu: 1-5; Ti6A14V titanium alloy: Balance; Ti6A14V titanium alloy is produced by Shandong Weigao Orthopedic Company, and its standard is GB / T 13810-1997. The chemical composition of Ti6A14V titanium alloy is as follows (by mass percentage): Al: 5.5-6.5; V: 3.5-4.5; Fe: 0.3; C: 0.08; N: 0.05; H: 0.012; O: 0.13; Ti: Balance.

[0023] This embodiment also proposes a method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy, including the following steps: S1: Prepare Ti6A14V titanium alloy rods produced by Shandong Weigao Orthopedics Co., Ltd. as the matrix material; S2: The matrix material in S1 is processed into a metal sheet, and then ground and polished until the surface roughness R of the metal sheet is achieved. <O.1; S3: Copper ions are implanted into the metal sheet processed in S2 using a pure metal plasma immersion ion implantation process to obtain a surface-modified anti-infective orthopedic fixation titanium alloy.

[0024] Example 4

[0025] A surface-modified, anti-infective orthopedic fixation titanium alloy, based on the chemical composition of Ti6A14V titanium alloy, is implanted with copper ions. Its chemical composition is as follows (by mass percentage): Cu: 1-5; Ti6A14V titanium alloy: Balance; Ti6A14V titanium alloy is produced by Shandong Weigao Orthopedic Company, and its standard is GB / T 13810-1997. The chemical composition of Ti6A14V titanium alloy is as follows (by mass percentage): Al: 5.5-6.5; V: 3.5-4.5; Fe: 0.3; C: 0.08; N: 0.05; H: 0.012; O: 0.13; Ti: Balance.

[0026] This embodiment also proposes a method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy, including the following steps: S1: Prepare Ti6A14V titanium alloy rods produced by Shandong Weigao Orthopedics Co., Ltd. as the matrix material; S2: The matrix material in S1 is processed into a metal sheet, and then ground and polished until the surface roughness R of the metal sheet is achieved. <O.1; S3: Copper ions are implanted onto the metal sheet processed in S2 using an ion beam assisted deposition process to obtain a surface-modified anti-infective orthopedic fixation titanium alloy.

[0027] Compared with conventional titanium alloys, the surface-modified anti-infective orthopedic fixation titanium alloys obtained in Examples 1 to 4 have SEM surface images as follows: Figure 3 As shown, SEM images of the surface-modified anti-infective orthopedic fixation titanium alloys obtained in Examples 1 to 4 are as follows. Figure 4 As shown in the table below, the comparison results between the two are as follows:

[0028] According to the table above, this first embodiment is the best embodiment. Based on the chemical composition of Ti6A14V titanium alloy, the present invention implants copper ions into the metal sheet using an implantation process. The mass percentage of Cu ions is 1-5%, which makes the fixed metal titanium alloy with implanted Cu ions have strong bactericidal effect and corrosion resistance, greatly reducing the incidence of orthopedic implant-related infections.

[0029] in addition Figure 5 In this study, A-D represent a 5 μm scale, and CLSM is used to detect Staphylococcus aureus biofilms. Figure 5 The EF in the figure is a 1.2 mm scale for CLSM detection of Staphylococcus epidermidis biofilm, in which dead bacteria emit red fluorescence and live bacteria emit green fluorescence.

[0030] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A surface-modified anti-infective orthopedic fixation titanium alloy, characterized in that, Based on the chemical composition of Ti6A14V titanium alloy, copper ions were implanted, and the chemical composition was as follows (by mass percentage): Cu: 1-5; Ti6A14V titanium alloy: Balance.

2. The surface-modified anti-infective orthopedic fixation titanium alloy according to claim 1, characterized in that, The Ti6A14V titanium alloy was produced by Shandong Weigao Orthopedics Co., Ltd., and its standard is GB / T 13810-1997.

3. The surface-modified anti-infective orthopedic fixation titanium alloy according to claim 1, characterized in that, The chemical composition of Ti6A14V titanium alloy is as follows (by mass percentage): Al：5.5-6.5； V：3.5-4.5； Fe: 0.3; C：0.08； N：0.05； H：0.012； O：0.13； Ti: Balance.

4. A method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy, used to prepare the anti-infective orthopedic fixation titanium alloy according to any one of claims 1-3, characterized in that, Includes the following steps: S1: Prepare Ti6A14V titanium alloy rods produced by Shandong Weigao Orthopedics Co., Ltd. as the matrix material; S2: The matrix material in S1 is processed into a metal sheet, and then ground and polished until the surface roughness R of the metal sheet is achieved. <O.1; S3: Copper ions are implanted into the metal sheet processed in S2 using an implantation process to obtain a surface-modified anti-infective orthopedic fixation titanium alloy.

5. The method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy according to claim 4, characterized in that, In step S3, copper ions are implanted onto the metal sheet processed in step S2 using a metal vapor vacuum arc ion source high-current metal ion implanter, with the implantation amount set at 10... 17 With 10 18 The processing parameters for Cu ion implantation are as follows: (The target amount is ions / cm²) Vacuum degree: 3.0*10 -3 ; Accelerating voltage: 40kV; Negative voltage: 1KV; Trigger voltage: 6kV; Arc voltage: 80V; Average charge state: 2.1; Energy injected: 80keV; Beam current density: 2mA.

6. The method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy according to claim 4, characterized in that, In step S3, copper ions are implanted onto the metal sheet processed in step S2 using a metal solid evaporation / arc ionization process.

7. The method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy according to claim 4, characterized in that, In step S3, copper ions are implanted onto the metal sheet processed in step S2 using a pure metal plasma immersion ion implantation process.

8. The method for preparing a surface-modified anti-infective orthopedic fixation titanium alloy according to claim 4, characterized in that, In step S3, copper ions are implanted onto the metal sheet processed in step S2 using an ion beam-assisted deposition process.

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