A membrane pump device and drug delivery system

Abstract

This invention provides a membrane pump device and a drug delivery system. The membrane pump device includes a power flow channel and a working flow channel, a valve assembly, and a metering tank located at the junction of the power flow channel and the working flow channel. The metering tank is equipped with an elastic membrane. Both the power flow channel and the working flow channel are connected to the metering tank and separated by the elastic membrane. The elastic membrane shifts towards the side with lower pressure in the power flow channel and the working flow channel due to pressure changes, allowing fluid to enter and exit the metering tank. The working flow channel includes an inlet section and an outlet section. The valve assembly includes multiple valves, with valves for opening and closing the flow channel in both the inlet and outlet sections. During operation, the power flow channel receives the driving fluid, which causes the elastic membrane to move, thereby pumping the fluid to be delivered out of the working flow channel. This invention can quantitatively output fluid, has a small overall structure, and is easy to carry.

Description

Technical Field

[0001] This invention relates to the field of drug delivery, and in particular to membrane pump technology used in drug delivery and drug delivery systems incorporating this membrane pump technology. Background Technology

[0002] Insulin therapy plays a crucial role in diabetes management, primarily through multiple daily subcutaneous injections and continuous infusion via insulin pumps. Insulin pumps are mainly divided into catheter-based and patch-based pumps. Patch-based insulin pumps are catheter-free, lighter, and smaller, offering better safety, comfort, and privacy to meet patients' needs for long-term use.

[0003] Patent documents published with publication numbers EP1874390B1 and CN113117184A describe a pusher-type drug delivery system. When energized, a shape memory alloy wire contracts, driving a ratchet structure to rotate. The ratchet structure is connected to a screw that pushes the drug solution. The rotation of the ratchet structure causes the screw to push the drug solution. The shape memory alloy wire is a small-volume, high-power-density electromechanical component. The ratchet structure amplifies the force of the shape memory alloy wire and provides precise pusher stepping. This design enables the miniaturization of drug delivery systems and is a core component of currently commercially available insulin pumps.

[0004] For insulin pumps worn close to the skin, a smaller size can effectively reduce safety issues caused by accidental activation or impact. Low wearing discomfort and privacy are also key concerns for users. In contrast, in push-type drug infusion designs, the pusher needs to occupy the same size space as the drug reservoir. With a fixed amount of medication stored in the reservoir, this limits the miniaturization of the insulin pump. Summary of the Invention

[0005] The present invention provides a membrane pump device that can be used for drug infusion, and a drug infusion system with the membrane pump technology, which is small in size, portable, and can output a quantitative amount.

[0006] This invention provides a membrane pump device, which includes a power flow channel and a working flow channel, a valve group, and a metering tank located at the junction of the power flow channel and the working flow channel;

[0007] The metering tank is equipped with an elastic membrane. The power flow channel and the working flow channel are connected to the metering tank and separated by the elastic membrane. The elastic membrane is shifted to the side with lower pressure in the power flow channel and the working flow channel due to pressure changes in the power flow channel and the working flow channel, so as to facilitate the entry and exit of fluid in the metering tank.

[0008] The working channel includes an inlet section and an outlet section. The inlet section of the working channel is the flow path from the inlet of the working channel to the metering tank, and the outlet section of the working channel is the flow path from the metering tank to the outlet of the working channel.

[0009] The valve group includes multiple valves, and the valves for opening and closing the flow channel are provided in both the inlet section and the outlet section of the working flow channel.

[0010] During operation of the membrane pump device, the power flow channel is used to receive the driving fluid, and the flow of the driving fluid causes the elastic membrane to move, thereby pushing the fluid to be transported in the working flow channel out.

[0011] Preferably, the power flow channel includes an inlet section and an outlet section. The inlet section of the power flow channel is the flow path from the inlet of the power flow channel to the metering tank, and the outlet section of the power flow channel is the flow path from the metering tank to the outlet of the power flow channel.

[0012] Preferably, both the inlet section and the outlet section of the power flow channel are equipped with valves for opening and closing the flow channel; the valves in the inlet section of the working flow channel and the valves in the outlet section of the power flow channel form a first group, and the valves in the outlet section of the working flow channel and the valves in the inlet section of the power flow channel form a second group, with each valve in each group having the same opening and closing state.

[0013] Preferably, the valves in each group are connected by a linkage mechanism and driven by the same driving force.

[0014] Preferably, the membrane pump device further includes a detection element disposed on the elastic membrane and moving with the elastic membrane, and a sensor disposed on the membrane pump device for detecting changes in the movement of the detection element, the sensor being used to output the operating status of the membrane pump device.

[0015] Preferably, the detection element is a magnet, and the sensor is a Hall sensor.

[0016] Preferably, the detection element is an elastic conductor, the resistance value of which changes with the deformation of the elastic conductor, and the sensor is a Wheatstone bridge.

[0017] Preferably, the driving fluid is a gas, liquid, or gas-liquid mixture, and the power flow channel is connected to a gas storage device, a proton exchange device, or a liquid driving device.

[0018] Preferably, the valve includes a valve body, a drive mechanism, and an elastic mechanism. The elastic mechanism and the drive mechanism are both connected to the valve body. A portion of the valve body is placed in the inlet section or the outlet section and is sealed by the elastic force of the elastic mechanism. The drive mechanism drives the valve body to overcome the elastic force of the elastic mechanism and open the inlet section or the outlet section.

[0019] The present invention also provides a drug delivery system, the drug delivery system comprising:

[0020] A drug reservoir, comprising a liquid storage chamber and a drive mechanism disposed in the liquid storage chamber to drive the flow of liquid, the liquid reservoir having an outlet for the fluid to flow out;

[0021] As described in any of the preceding membrane pump devices, the inlet section of the working flow channel is connected to the outlet of the reservoir;

[0022] A power source, which is connected to the power flow channel, and the power source contains a driving fluid that flows into the power flow channel.

[0023] Preferably, the driving mechanism includes a piston placed in the liquid storage chamber and a pneumatic tube connected to the piston; the power source is a proton exchange device or a gas storage device, and the power source is connected to the pneumatic tube and the power flow channel respectively through a gas passage; wherein, the proton exchange device generates gas based on the principle of chemical reaction or physical change.

[0024] Preferably, the driving mechanism includes a piston placed in the liquid storage chamber and a pneumatic tube connected to the piston; the power source is a first gas and a second gas generating device, the first gas output pipe of the first gas and the second gas generating device is connected to the power flow channel so that the first gas is used as the driving fluid, and the second gas output pipe of the first gas and the second gas generating device is connected to the pneumatic tube so that the second gas is used as the power to drive the piston to move.

[0025] Preferably, a pressure stabilizing mechanism is provided at the connection between the second gas output pipe and the pneumatic pipe.

[0026] Preferably, the pressure stabilizing mechanism includes a microchannel connecting the pneumatic tube and the second gas output tube, an elastic mechanism, and a valve body connected to the elastic mechanism. A portion of the valve body is placed in the microchannel and is sealed by the elastic force of the elastic mechanism.

[0027] Preferably, the first gas and second gas generating device includes a housing, a support structure placed inside the housing, and a first metal electrode plate, a first metal catalyst layer and a membrane electrode, a second metal catalyst layer and a second metal electrode plate sequentially pressed onto the support structure. The support structure is provided with a water-carrying porous material. The first metal electrode plate and the second metal electrode plate are respectively connected to the positive electrode and the negative electrode. The first gas output pipe and the second gas output pipe are both connected to the inside of the housing.

[0028] Preferably, the first gas and the second gas generating device further include a gas pressure detection mechanism disposed on the first gas output pipe and / or the second gas output pipe, the gas pressure detection mechanism being used to output a control signal to control the disappearance of the voltage between the positive electrode and the negative electrode.

[0029] Preferably, the air pressure detection mechanism includes a first conductor and a second conductor positioned at intervals, and a third conductor located on the same side of the first conductor and the second conductor. The third conductor is connected to the first gas output pipe or the second gas output pipe and is disposed in a non-contact manner with the first conductor and the second conductor. When the pressure in the first gas output pipe or the second gas output pipe increases, the third conductor is driven to move toward the first conductor and the second conductor. When the third conductor contacts and conducts electricity with the first conductor and the second conductor, the air pressure detection mechanism outputs the control signal.

[0030] Preferably, the third conductor is attached to the first gas output pipe or the second gas output pipe via an elastic membrane.

[0031] Preferably, the power source includes a proton exchange device, which is connected to the power flow channel via a gas path; wherein the proton exchange device generates gas based on the principle of chemical reaction or physical change, and absorbs and consumes the gas in the metering pool.

[0032] Preferably, the power flow channel includes an inlet section and an outlet section. The inlet section is the flow path from the inlet of the power flow channel to the metering cell, and the outlet section is the flow path from the metering cell to the outlet of the power flow channel. The power source includes a first proton exchange device and a second proton exchange device. The first proton exchange device is connected to the inlet section of the power flow channel via a gas path, and the second proton exchange device is connected to the outlet section of the power flow channel via a gas path. The first proton exchange device generates gas based on a chemical reaction or physical change, and the second proton exchange device absorbs and consumes the gas in the metering cell.

[0033] Preferably, the medicine storage device is equipped with a detection mechanism for detecting the amount of medicine in the storage chamber.

[0034] Preferably, the driving mechanism includes a piston placed in the liquid storage chamber, and the detection mechanism includes a tested element placed on the piston and moving with the piston, and a plurality of Hall elements placed at intervals on the wall of the liquid storage chamber, the Hall elements being used to detect the tested element to calculate the position of the piston.

[0035] Preferably, the driving mechanism includes a piston placed in the liquid storage chamber, and the detection mechanism includes a conductive element placed on the piston and moving with the piston, and electrode plates placed at different positions on the wall of the liquid storage chamber. The conductive element is connected to a charged fixed electrode and makes contact with the electrode plates at different positions when it moves with the piston, thereby detecting the position of the piston.

[0036] As described above, the membrane pump device and drug delivery system of the present invention have the following beneficial effects: The membrane pump device drives the elastic membrane to shift towards the side with lower pressure in the power flow channel and the working flow channel by changing the pressure on both sides of the elastic membrane. The change in pressure on both sides of the elastic membrane is controlled by opening and closing various valves, thereby alternating the injection of fluid into the power flow channel and the working flow channel to change the pressure within the flow channel. It can quantitatively output fluid. Based on the design of the flow channel and the elastic membrane, it is easy to integrate into a small-volume structure, making it convenient to carry or integrate into other fluid systems, such as drug delivery systems. The drug delivery system using this membrane pump device can quantitatively inject drugs; the overall size is small after integrating the membrane pump device; furthermore, the drug reservoir and the membrane pump device can be driven by the same power source, making the system structure simpler and smaller in size. Attached Figure Description

[0037] Figure 1 The diagram shown is a schematic diagram of a membrane pump device provided in one embodiment of the present invention.

[0038] Figure 2 The figure shown is an embodiment of the membrane pump device provided in one embodiment of the present invention.

[0039] Figure 3 Displayed as Figure 2 A partial structural diagram of the membrane pump device shown.

[0040] Figure 4 The diagram shown is a schematic diagram of a membrane pump device provided in another embodiment of the present invention.

[0041] Figure 5 The diagram shown is a schematic diagram of a membrane pump device provided in another embodiment of the present invention.

[0042] Figure 6 The diagram shown is a schematic representation of a drug delivery system provided in one embodiment of the present invention.

[0043] Figure 7 The diagram shown is an embodiment of a drug delivery system provided in one embodiment of the present invention.

[0044] Figure 8 The diagram shown is a schematic representation of a drug delivery system provided in another embodiment of the present invention.

[0045] Figure 9 The diagram shown is a schematic diagram of the drug infusion system provided in another embodiment of the present invention.

[0046] Figure 10 The diagram shown is a schematic of the elastic membrane state detection component in the membrane pump device of the present invention.

[0047] Figure 11 The figure shown is an embodiment of the medicine storage device of the present invention.

[0048] Figure 12 The diagram shown illustrates an embodiment of the first and second gas generating apparatus of the present invention.

[0049] Figure 13 The figure shown is an embodiment of the air pressure detection mechanism of the present invention.

[0050] Figure 14 The figure shown is an embodiment of the detection mechanism for drug dosage detection according to the present invention.

[0051] Figure 15 The figure shown is another embodiment of the detection mechanism for drug dosage detection according to the present invention.

[0052] Component designation explanation

[0053] 100 medicine storage container

[0054] 200 Power Source

[0055] 200a First Proton Exchanger

[0056] 200b Second Proton Exchanger

[0057] 300 valve assembly

[0058] Valves 300a, 300b, 300c, and 300d (first to fourth valves)

[0059] 400 membrane pump unit

[0060] 101 Piston

[0061] 102 Drive mechanism

[0062] 103 Voltage stabilizing mechanism

[0063] 104 Liquid Storage Chamber

[0064] 105 Exports

[0065] 106 Valve body

[0066] 107 Pneumatic Tube

[0067] 108 Components under test

[0068] 109 Hall element

[0069] 110 Conductive components

[0070] 111 Take-up device

[0071] 112 Electrode Plate

[0072] 113 Fixed Electrode

[0073] 114 Hook

[0074] 201 Supporting Structure

[0075] 202 First Metal Plate

[0076] 203 First Metal Catalyst Layer

[0077] 204 membrane electrode

[0078] 205 Porous Materials

[0079] 206 Seals

[0080] 207 First Gas Passage

[0081] 208 Second Gas Passage

[0082] 251 Pipe pressure

[0083] 252 Elastic Membrane

[0084] 253 Bearing Mechanism

[0085] 254 First Conductor

[0086] 255 Second Conductor

[0087] 256 Third Conductor

[0088] 401 Dynamic Flow Channel

[0089] 402 Workflow

[0090] 403 quantitative cell

[0091] 404 elastic film

[0092] 405 Detection Element

[0093] 406 sensor

[0094] 407 Valve Interface Detailed Implementation

[0095] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification.

[0096] It should be understood that the structures, proportions, sizes, etc., depicted in the accompanying drawings of this specification are merely for illustrative purposes to aid those skilled in the art and are not intended to limit the scope of the invention. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effectiveness and purpose of the invention, should still fall within the scope of the technical content disclosed in this invention. Furthermore, the terms such as "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity and are not intended to limit the scope of the invention. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of the invention's implementation.

[0097] This application provides a membrane pump device. The membrane pump device of this embodiment can be used as a drive mechanism for a drug infusion system, or as a drive mechanism for other fluid control outputs. For example... Figures 1 to 3 As shown, in this embodiment, the membrane pump device 400 includes a power flow channel 401 and a working flow channel 402, a valve group 300, and a metering tank 403 located at the junction of the power flow channel 401 and the working flow channel 402. The metering tank 403 is provided with an elastic membrane 404. Both the power flow channel 401 and the working flow channel 402 are connected to the metering tank 403 and separated by the elastic membrane 404. Both the power flow channel 401 and the working flow channel 402 are divided into an inlet section and an outlet section by the metering tank. The inlet section is the flow path from the inlet of the flow channel to the metering tank, and the outlet section is the flow path from the metering tank to the outlet of the flow channel. See Figure 3 The diagram shows a working flow channel inlet 421, a working flow channel outlet 422, and a power flow channel inlet 411. The elastic membrane 404 is shifted towards the side with lower pressure in the power flow channel 401 and the working flow channel due to pressure changes in the power flow channel 401 and the working flow channel 402, so as to allow the fluid in the metering tank 403 to enter and exit. The valve group 300 includes multiple valves, and each inlet section and outlet section is equipped with a valve to open and close the flow channel. The membrane pump device has a valve interface 407 on the housing, and the aforementioned valves are located at the valve interface 407. When the membrane pump device is in operation, the power flow channel 401 is used to allow the driving fluid to flow in, and the flow of the driving fluid causes the elastic membrane to move, thereby pushing the fluid to be transported in the working flow channel 402 to be pumped out.

[0098] In this embodiment, the membrane pump device drives the elastic membrane 404 to shift towards the side with lower pressure in the power flow channel 401 and the working flow channel 402 by changing the pressure on both sides of the elastic membrane. This pressure change is achieved by controlling the opening and closing of valves, allowing fluid to be alternately injected into the metering tank in the power flow channel and the working flow channel 402, thus altering the pressure. For example, when the valve at the inlet section of the power flow channel 401 is open while the valve at the outlet section is closed, the pressure in the power flow channel increases, causing the elastic membrane 404 to shift towards the working flow channel, squeezing the fluid to be transported from the metering tank and outputting it. Conversely, the fluid to be transported in the working flow channel 402 enters the metering tank, while the driving fluid in the power flow channel is discharged. If a drug solution flows into the working flow channel 402, drug injection can be achieved. To ensure the periodic or intermittent pumping of the fluid to be transported, valves are installed in both the inlet and outlet sections of the power flow channel 401 and the working flow channel 402. By combining and controlling the opening and closing states of these valves, the repeated pumping of the fluid to be transported is achieved.

[0099] The membrane pump device in this embodiment is manufactured by 3D printing, and the power flow channel 401 and the working flow channel 402 are microchannels. The integration of the flow channels is achieved through 3D printing technology, which can make the flow channel structure with elastic membrane smaller in volume. The membrane pump device can be made into a thin sheet structure by using fluid microfluidics technology.

[0100] As a preferred embodiment of the metering tank, the space formed by the elastic membrane 404 and the working flow channel 402 is designed to be connected to the working flow channel 402. That is, when the elastic membrane is in a flat state, the volume of the space can be related to the flow rate of the fluid to be transported by three-dimensional modeling or size design. In addition, the elasticity of the elastic membrane is set to be related to the pressure of the pumped amount of the fluid to be transported.

[0101] To facilitate the monitoring of the membrane pump device's status, in one embodiment, see... Figure 10 As shown, the membrane pump device also includes a detection element 405 disposed on the elastic membrane 404 and moving with the elastic membrane 404, and a sensor 406 disposed on the membrane pump device for detecting changes in the movement of the detection element 405. The sensor 406 is used to output the operating status of the membrane pump device. The detection element and sensor can be implemented using displacement detection technology, mechanical detection technology, or resistance, voltage, electromagnetic, and other detection technologies. In a preferred embodiment, the sensor is a fixedly disposed Hall sensor, and the detection element is a magnet attached to the elastic membrane. When the elastic membrane is compressed and deforms to one side, squeezing out the fluid to be transported in the metering tank, the magnet moves with the elastic membrane toward the metering tank, and the Hall sensor detects the change in the magnet to monitor the operating status of the elastic membrane. The structure of the detection element is not limited to this; it can also be an elastic conductor, the resistance value of which changes with the deformation of the elastic conductor, and the sensor is a Wheatstone bridge, thereby monitoring the movement of the elastic membrane by the change in the resistance value of the elastic conductor.

[0102] In one embodiment, the driving fluid is a gas, liquid, or gas-liquid mixture. The power flow channel 401 is connected to a gas storage device, a proton exchange device, or a liquid driving device. The deformation of the elastic membrane is achieved through the flow of the gas, liquid, or gas-liquid mixture, thereby pumping out the fluid to be transported within the working flow channel. In one embodiment, the gas source is a gas storage container with a positive pressure inside. In another embodiment, the gas source is a proton exchange device. The proton exchange device generates gas based on chemical reactions such as water electrolysis, the reaction of acid with carbonate ions to produce carbon dioxide, the reaction of acid with metal to produce a first gas, and heating a solid to produce a second gas; or it generates gas based on physical changes such as dry ice vaporization and liquid dissolution leading to gas escape. In another embodiment, the liquid driving device changes the liquid pressure through heating, compression, or other methods.

[0103] As an example, the first gas can be hydrogen and the second gas can be oxygen; in other examples, the first gas can also be oxygen and the second gas can also be hydrogen. Of course, the first and second gases can also be any other gases that can be generated by the proton exchange device described above, such as carbon dioxide, etc.

[0104] To better control the opening and closing of each valve, as an embodiment, the valve group 300 in the inlet section of the working flow channel 402 and the valve group 300 in the outlet section of the power flow channel 401 form a first group, and the valve group 300 in the outlet section of the working flow channel and the valve group 300 in the inlet section of the power flow channel 401 form a second group. The opening and closing states of each valve in each group are consistent. The valve may include a valve body, a drive mechanism, and an elastic mechanism. Both the elastic mechanism and the drive mechanism are connected to the valve body. A portion of the valve body is placed in the inlet or outlet section and is sealed by the elastic force of the elastic mechanism. The drive mechanism drives the valve body to overcome the elastic force of the elastic mechanism and open the inlet or outlet section. As a specific embodiment of the valve body, it may be a ball valve or a spherical crown structure, which contacts the power flow channel or working flow channel through the spherical surface to ensure the sealing and blocking of the fluid in the flow channel. The elastic mechanism generally adopts a spring, leaf spring, tension spring, or other elastic structure, but it may also be other structures with elastic potential energy. The drive mechanism in this embodiment is not limited to electric drive, mechanical drive, pneumatic drive, or other drive technologies.

[0105] To achieve better synchronized control, the valves in each group are connected by a linkage mechanism and driven by the same driving force, simplifying the drive mechanism and further achieving synchronized movement. The linkage mechanism can be mechanical or electrically controlled, and is not limited here. In other embodiments, each valve can also be controlled independently, and its state can be adjusted separately.

[0106] In another embodiment, please refer to Figures 1 to 3 See Figure 4This application also provides a membrane pump device. In this embodiment, the membrane pump device has only one working channel 402 divided into an inlet section and an outlet section by a metering tank. The inlet section of the working channel 402 is the flow path from the inlet of the working channel 402 to the metering tank 400, and the outlet section of the working channel 402 is the flow path from the metering tank 400 to the outlet of the working channel 402. The power channel 401 has only one section, which serves as both the inlet and outlet sections. In this embodiment, the valve group 300 includes two valves, which are located in the inlet section and the outlet section of the working channel 402, respectively.

[0107] In yet another embodiment, please refer to Figures 1 to 3 See Figure 5 This application also provides a membrane pump device. In this embodiment, both the power flow channel 401 and the working flow channel 402 are divided into an inlet section and an outlet section by a metering tank. In this embodiment, the valve group 300 includes two valves, which are located in the inlet section and the outlet section of the working flow channel 402, respectively.

[0108] This application also provides a drug delivery system, such as Figure 6 and Figure 7 As shown, the drug delivery system includes:

[0109] The drug reservoir 100 includes a liquid storage chamber and a drive mechanism 102 placed in the liquid storage chamber to drive the liquid flow. The liquid reservoir has an outlet for the fluid to flow out.

[0110] like Figures 1 to 3 In the corresponding embodiment, the membrane pump device 400 has its inlet section of the working flow channel connected to the outlet of the reservoir 100.

[0111] The power source 200 is connected to the power flow channel 401, and the power source contains a driving fluid that flows into the power flow channel 401.

[0112] The membrane pump device of this embodiment includes a valve group 300, which may include a first valve 300a on the inlet section of the working flow channel and a second valve 300b on the outlet section of the working flow channel, a third valve 300c on the inlet section of the power flow channel and a fourth valve 300d on the outlet section of the power flow channel. The first valve 300a and the fourth valve 300d are one group, and the second valve 300b and the third valve 300c are another group. The drug pumping process includes two working states. In working state 1, the first valve 300a and the fourth valve 300d are in the open state, and the second valve 300b and the third valve 300c are in the closed state. In this state, the drug reservoir 100 pumps the drug solution into the metering tank 403 of the membrane pump device under the action of a preset force, and discharges the air in the membrane pump device. Switching to working state 2 means that the first valve 300a and the fourth valve 300d are closed, while the second valve 300b and the third valve 300c are open. The power source 200 generates fluid pressure to pump the liquid medicine in the metering tank out of the outflow section of the working channel. By switching between working states 1 and 2 repeatedly, the metered discharge of the liquid medicine can be achieved.

[0113] The driving power for the aforementioned drug reservoir 100 and membrane pump device 400 can be independently set or driven by the same driving device. To make the drug delivery system small and compact, in this embodiment, the driving power for both the drug reservoir 100 and membrane pump device 400 is gas, which can be achieved by the same proton exchange device; alternatively, it can be achieved by the same liquid circulation mechanism using liquid as the power source. The aforementioned power source can be a gas storage device, a proton exchange device, or a liquid driving device connected together. The deformation of the elastic membrane in the metering tank is achieved through the flow of gas, liquid, or a gas-liquid mixture, thereby pumping out the fluid to be delivered in the working channel and providing the driving force for the drug reservoir. Specifically, it can be as follows: Figure 7 and Figure 11 As shown, the drive mechanism 102 includes a piston 101 placed in the liquid storage chamber 104 and a pneumatic tube 107 connected to the piston 101. The power source can be a gas storage device or a proton exchange device, specifically a first gas and a second gas generating device. The first gas output pipe of the first gas and the second gas generating device is connected to the power flow channel 401 so that the first gas is used as the driving fluid. The second gas output pipe of the first gas and the second gas generating device is connected to the pneumatic tube so that the second gas is used as the power to drive the piston 101 to move.

[0114] Medicine storage container

[0115] In one embodiment of the above-described medicine storage device 100, such as Figure 11As shown, the drug reservoir 100 is a piston-type syringe, and the movement of the piston 101 is driven by the aforementioned power source. The liquid storage chamber 104 is the syringe body, and a drive mechanism 102 for driving the piston is fixedly provided on one side of the syringe body. In this embodiment, the drive mechanism can specifically be a pneumatic pipe 107 connected to the piston. The pneumatic pipe 107 is connected to the second gas output pipe of the first gas and second gas generating devices. The second gas produced in the first gas and second gas generating devices enters the pneumatic pipe 107 through the second gas output pipe. As the pressure in the pneumatic pipe 107 increases, it pushes the piston to move, causing the liquid in the liquid storage chamber to flow and be pushed out from the outlet 106. More preferably, a pressure stabilizing mechanism 103 is provided at the connection between the second gas output pipe and the pneumatic pipe 107 to stabilize the gas pressure and prevent the pressure in the second gas output pipe and the pneumatic pipe 107 from being too high.

[0116] As one embodiment of the aforementioned voltage stabilizing mechanism, such as Figure 11 As shown, it may include a microchannel connecting the pneumatic tube 107 and the second gas output tube, an elastic mechanism, and a valve body 106 connected to the elastic mechanism. Part of the valve body is placed in the microchannel and is sealed by the elastic force of the elastic mechanism. As an embodiment of the valve body 106, the channel wall constituting the microchannel integrates a first elastic membrane. A compression mechanism, such as a ball valve or a ball-shaped valve, is provided on the side of the first elastic membrane away from the microchannel. The ball valve or ball-shaped valve is connected to the aforementioned elastic mechanism. Initially, the elastic force of the elastic mechanism causes the ball valve 110 or ball-shaped valve to apply a closing pressure to the first elastic membrane, thereby closing the valve body 106. When the pressure in the pneumatic tube 107 is greater than the closing pressure, the ball valve or ball-shaped valve will compress the elastic mechanism, causing the valve body 106 to open, thereby releasing the excessive pressure in the pneumatic tube 107 and achieving a pressure stabilizing effect.

[0117] The aforementioned medicine reservoir 100 is equipped with a detection mechanism to monitor the amount of medicine in the reservoir chamber. This mechanism provides feedback on the remaining amount, facilitating replacement and improving ease of use and safety. Figure 14 As shown, one embodiment of the detection mechanism includes a test element 108 placed on a piston 101 and moving with the piston 101, and multiple Hall elements 109 spaced apart on the wall of the storage chamber. The Hall elements 108 are used to detect the test element 108 to calculate the position of the piston 101. The piston 101 is in close contact with the inner wall of the drug infusion cylinder. The test element 108 (such as a magnet) is fixed on the piston 101. Two Hall elements 109 are located on the outer wall of the drug infusion cylinder, 15-20 mm apart, and symmetrical about the central axis along the length of the drug infusion cylinder. When the piston 101 moves within the drug infusion cylinder, pushing the drug liquid out, the magnet moves with the piston 101 within the drug infusion cylinder. The Hall elements 109 calculate the position of the piston 101 within the drug infusion cylinder by detecting changes in the magnetic field strength of the magnet, and calculate the remaining amount of drug in the drug infusion cylinder based on the position of the piston 101.

[0118] like Figure 15 As shown, another embodiment of the above-mentioned detection mechanism is described. The detection mechanism includes a conductive element 110 placed on a piston 101 and moving with the piston 101, and electrode plates 112 placed at different positions on the wall of the liquid storage chamber. The conductive element 110 is connected to a charged fixed electrode 113, and makes contact with the electrode plates 112 at different positions as it moves with the piston 101, thereby detecting the position of the piston 101. In this embodiment, all electrode plates 112 are circumferentially distributed around the wall of the liquid storage chamber. The piston 101 is in close contact with the wall of the liquid storage chamber. A hook 114 is provided on the piston 101. One end of the conductive element 110 (such as a conductive wire) is fixed to the fixed electrode 113 and is in communication with the fixed electrode 113, while the other end is fixed to a take-up device 111. The take-up device 111 provides a pulling force to the conductive element 110, so that the part between the conductive element 110 and the hook 114 is always in a taut state. When the piston 101 moves to different positions, one or more of the electrode plates will form a conductive circuit with the fixed electrode 113 through the connection of the conductive element 110. At this time, the position of the piston 101 can be determined by detecting the conductivity between the electrode plate 112 and the fixed electrode 113 through external signals, thereby calculating the remaining amount of drug in the storage chamber.

[0119] Power source

[0120] As one embodiment of the power source 200, the power source 200 in this embodiment can be a proton exchange device or a gas storage device; such as a high-pressure gas storage device, a solid-liquid / liquid-liquid gas-generating chemical reaction device (e.g., chemical reactions such as electrolysis of water, reaction of acid with carbonate to produce carbon dioxide, reaction of acid with metal to produce a first gas, heating of solid to produce a second gas, reaction of acid with baking soda or baking soda solution to produce gas), or a physical reaction to generate gas device, such as physical reactions such as dry ice vaporization, liquid dissolution and gas escape. As a specific embodiment, the power source 200 can use a first gas and a second gas generating device to generate a first gas and a second gas to drive the membrane pump and the reservoir to work, realizing the quantitative output of the drug solution. See Figure 12As shown, the first gas and second gas generating device includes a housing, a support structure 201 placed inside the housing, and a first metal electrode 202, a first metal catalyst layer 203, a membrane electrode 204, a second metal catalyst layer, and a second metal electrode 204 sequentially pressed onto the support structure 201. The support structure 201 contains a water-carrying porous material 205. The first metal electrode 202 and the second metal electrode 204 are respectively connected to the positive electrode and the negative electrode. Both the first gas output pipe and the second gas output pipe are connected to the inside of the housing. A symmetrical structure is formed on both sides of the membrane electrode 204, i.e., the first metal electrode 202, the first metal catalyst layer 203, the second metal catalyst layer, and the second metal electrode 204 are symmetrically arranged about the membrane electrode 204. The first gas and the second gas are generated on both sides respectively. The first gas is generated on the upper side inside the housing and enters the power flow channel of the membrane pump device through the first gas channel 207. The second gas is generated on the lower side inside the housing and enters the pneumatic tube of the drug reservoir through the second gas channel 208. In this embodiment, a sealing element 206 is provided inside the housing to prevent gas leakage. The support structure 201 includes multiple support columns and multiple gas channels. Porous material 205 is loaded between the support columns of the support structure and pressed onto the outside of the two metal plates by the support structure 201. During assembly, the support structure 201 provides pressure to stack and press the first metal plate 202, the first metal catalyst layer 203 and the membrane electrode 204, the second metal catalyst layer and the second metal plate tightly. After the porous material 205 is wetted with water, the water comes into contact with the metal catalyst layer. When the two metal plates are connected to the negative and positive electrodes respectively, and when there is a voltage between the positive and negative electrodes, the first gas is generated from the first metal catalyst layer 203 and the second gas is generated from the second metal catalyst layer.

[0121] In one embodiment, the first gas and second gas generating device further includes a gas pressure detection mechanism disposed on the first gas output pipe and / or the second gas output pipe. The gas pressure detection mechanism is used to output a control signal to control the disappearance of the voltage between the positive electrode and the negative electrode.

[0122] As one embodiment of a barometric pressure testing mechanism, see Figure 13As shown, it includes a first conductor 254 and a second conductor 255 spaced apart, and a third conductor 256 located on the same side as the first conductor 254 and the second conductor 255. The third conductor 256 is connected to the first gas output pipe or the second gas output pipe and is not in contact with the first conductor 254 and the second conductor 255. As the pressure 251 in the first gas output pipe or the second gas output pipe increases, the third conductor 256 is driven to move towards the first conductor 254 and the second conductor 255. When the third conductor 256 is in contact with both the first conductor 254 and the second conductor 255 and conducts electricity, the gas pressure detection mechanism outputs a control signal, indicating that the pressure 251 in the pipe has reached a preset threshold, and it is necessary to shut down the generation of the first gas and the second gas, which can de-energize the two metal plates, that is, control the voltage between the positive electrode and the negative electrode to disappear. The first conductor 254 and the second conductor 255 can be positioned and fixed by the bearing mechanism 253. The third conductor 256 can be attached to the first gas output pipe or the second gas output pipe by the elastic membrane 252.

[0123] The aforementioned first gas and second gas device is not limited to this; it can be an existing device capable of generating the first gas and the second gas, or it can be other proton exchange devices, or it can be a gas circulation mechanism.

[0124] In another embodiment, please refer to Figure 6 , Figure 7 , Figures 10 to 15 See Figure 8 This application also provides a drug infusion system, wherein the membrane pump device in the drug infusion system in this embodiment is as follows: Figure 4 The membrane pump device in the corresponding embodiment. The power source 200 in this embodiment may include a proton exchange device, and the power source 200 is connected to the power flow channel 401 through a gas path; wherein, the proton exchange device generates gas based on the principle of chemical reaction or physical change, and absorbs and consumes the gas in the metering cell; that is, the power source 200 in this embodiment can both generate gas and consume gas.

[0125] In yet another embodiment, please refer to Figure 6 , Figure 7 , Figures 10 to 15 See Figure 9 This application also provides a drug infusion system, wherein the membrane pump device in the drug infusion system in this embodiment is as follows: Figure 5The membrane pump device in the corresponding embodiment. The power source 200 in this embodiment may include a first proton exchange device 200a and a second proton exchange device 200b. The first proton exchange device 200a is connected to the inlet section of the power flow channel 401 through a gas path, and the second proton exchange device 200b is connected to the outlet section of the power flow channel 401 through a gas path. The first proton exchange device 200a generates gas based on the principle of chemical reaction or physical change, and the second proton exchange device 200b absorbs and consumes the gas in the metering pool.

[0126] Therefore, this invention effectively overcomes the various shortcomings of the prior art and has high industrial application value.

[0127] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A membrane pump device, characterized in that, The membrane pump device includes a power flow channel and a working flow channel, a valve group, and a metering tank located at the junction of the power flow channel and the working flow channel; The metering tank is equipped with an elastic membrane. The power flow channel and the working flow channel are both connected to the metering tank and separated by the elastic membrane. The elastic membrane shifts to the side with lower pressure in the power flow channel and the working flow channel due to pressure changes, thereby facilitating the entry and exit of fluid in the metering tank. The working flow channel includes an inlet section and an outlet section. The inlet section of the working flow channel is the flow path from the inlet of the working flow channel to the metering tank, and the outlet section of the working flow channel is the flow path from the metering tank to the outlet of the working flow channel. The valve group includes multiple valves, and the valves for opening and closing the flow channel are provided in both the inlet section and the outlet section of the working flow channel. During operation of the membrane pump device, the power flow channel is used to receive the driving fluid, and the flow of the driving fluid causes the elastic membrane to move, thereby pushing the fluid to be transported in the working flow channel out.

2. The membrane pump device according to claim 1, characterized in that: The power flow channel includes an inlet section and an outlet section. The inlet section of the power flow channel is the flow path from the inlet of the power flow channel to the metering tank, and the outlet section of the power flow channel is the flow path from the metering tank to the outlet of the power flow channel.

3. The membrane pump device according to claim 2, characterized in that: The inlet section and the outlet section of the power flow channel are both equipped with valves for opening and closing the flow channel; the valves in the inlet section of the working flow channel and the valves in the outlet section of the power flow channel form a first group, and the valves in the outlet section of the working flow channel and the valves in the inlet section of the power flow channel form a second group, with the opening and closing states of each valve in each group being consistent.

4. The membrane pump device according to claim 3, characterized in that: The valves in each group are connected by a linkage mechanism and driven by the same driving force.

5. The membrane pump device according to claim 1, characterized in that: The membrane pump device further includes a detection element disposed on the elastic membrane and moving with the elastic membrane, and a sensor disposed on the membrane pump device for detecting changes in the movement of the detection element. The sensor is used to output the operating status of the membrane pump device.

6. The membrane pump device according to claim 5, characterized in that: The detection element is a magnet, and the sensor is a Hall sensor.

7. The membrane pump device according to claim 5, characterized in that: The detection element is an elastic conductor, and the resistance value of the elastic conductor changes with the deformation of the elastic conductor. The sensor is a Wheatstone bridge.

8. The membrane pump device according to claim 1, characterized in that: The driving fluid is a gas, liquid, or gas-liquid mixture, and the power flow channel is connected to a gas storage device, a proton exchange device, or a liquid driving device.

9. The membrane pump device according to claim 1, characterized in that: The valve includes a valve body, a drive mechanism, and an elastic mechanism. The elastic mechanism and the drive mechanism are both connected to the valve body. A portion of the valve body is placed in the inlet section or the outlet section and is sealed by the elastic force of the elastic mechanism. The drive mechanism drives the valve body to overcome the elastic force of the elastic mechanism and open the inlet section or the outlet section.

10. A drug delivery system, characterized in that: The drug delivery system includes: A drug reservoir, comprising a liquid storage chamber and a drive mechanism disposed in the liquid storage chamber to drive the flow of liquid, the liquid reservoir having an outlet for the fluid to flow out; The membrane pump device according to any one of claims 1 to 9, wherein the inlet section of the working flow channel is connected to the outlet of the reservoir; A power source, which is connected to the power flow channel, and the power source contains a driving fluid that flows into the power flow channel.

11. The drug delivery system according to claim 10, characterized in that: The driving mechanism includes a piston placed in the liquid storage chamber and a pneumatic tube connected to the piston; the power source includes a proton exchange device or a gas storage device, and the power source is connected to the pneumatic tube and the power flow channel respectively through a gas passage; wherein, the proton exchange device generates gas based on the principle of chemical reaction or physical change.

12. The drug delivery system according to claim 10, characterized in that: The driving mechanism includes a piston placed in the liquid storage chamber and a pneumatic tube connected to the piston; the power source is a first gas and a second gas generating device, the first gas output pipe of the first gas and the second gas generating device is connected to the power flow channel so that the first gas is used as the driving fluid, and the second gas output pipe of the first gas and the second gas generating device is connected to the pneumatic tube so that the second gas is used as the power to drive the piston to move.

13. The drug delivery system according to claim 12, characterized in that: A pressure stabilizing mechanism is provided at the connection point between the second gas output pipe and the pneumatic pipe.

14. The drug delivery system according to claim 13, characterized in that: The pressure stabilizing mechanism includes a microchannel connecting the pneumatic tube and the second gas output tube, an elastic mechanism, and a valve body connected to the elastic mechanism. A portion of the valve body is placed in the microchannel and is sealed by the elastic force of the elastic mechanism.

15. The drug delivery system according to claim 12, characterized in that: The first and second gas generating devices include a housing, a support structure placed inside the housing, and a first metal electrode plate, a first metal catalyst layer and a membrane electrode, a second metal catalyst layer and a second metal electrode plate sequentially pressed onto the support structure. The support structure is provided with a water-carrying porous material. The first metal electrode plate and the second metal electrode plate are respectively connected to the positive electrode and the negative electrode. The first gas output pipe and the second gas output pipe are both connected to the inside of the housing.

16. The drug delivery system according to claim 12, characterized in that: The first gas and the second gas generating device further include a gas pressure detection mechanism disposed on the first gas output pipe and / or the second gas output pipe, the gas pressure detection mechanism being used to output a control signal to control the disappearance of the voltage between the positive electrode and the negative electrode.

17. The drug delivery system according to claim 16, characterized in that: The air pressure detection mechanism includes a first conductor and a second conductor positioned at intervals, and a third conductor located on the same side of the first conductor and the second conductor. The third conductor is connected to the first gas output pipe or the second gas output pipe and is not in contact with the first conductor and the second conductor. When the pressure in the first gas output pipe or the second gas output pipe increases, the third conductor is driven to move toward the first conductor and the second conductor. When the third conductor contacts and conducts with the first conductor and the second conductor, the air pressure detection mechanism outputs the control signal.

18. The drug delivery system according to claim 17, characterized in that: The third conductor is attached to the first gas output pipe or the second gas output pipe via an elastic membrane.

19. The drug delivery system according to claim 10, characterized in that: The power source includes a proton exchange device, which is connected to the power flow channel via a gas path; wherein the proton exchange device generates gas based on the principle of chemical reaction or physical change, and absorbs and consumes the gas in the metering pool.

20. The drug delivery system according to claim 10, characterized in that: The power flow channel includes an inlet section and an outlet section. The inlet section is the flow path from the inlet of the power flow channel to the metering cell, and the outlet section is the flow path from the metering cell to the outlet of the power flow channel. The power source includes a first proton exchange device and a second proton exchange device. The first proton exchange device is connected to the inlet section of the power flow channel via a gas path, and the second proton exchange device is connected to the outlet section of the power flow channel via a gas path. The first proton exchange device generates gas based on a chemical reaction or physical change, and the second proton exchange device absorbs and consumes the gas in the metering cell.

21. The drug delivery system according to claim 10, characterized in that: The medicine storage device is equipped with a detection mechanism to detect the amount of medicine in the storage chamber.

22. The drug delivery system according to claim 21, characterized in that: The driving mechanism includes a piston placed in the liquid storage chamber, and the detection mechanism includes a tested element placed on the piston and moving with the piston, and a plurality of Hall elements placed at intervals on the wall of the liquid storage chamber. The Hall elements are used to detect the tested element to calculate the position of the piston.

23. The drug delivery system according to claim 21, characterized in that: The driving mechanism includes a piston placed in the liquid storage chamber, and the detection mechanism includes a conductive element placed on the piston and moving with the piston, and electrode plates placed at different positions on the wall of the liquid storage chamber. The conductive element is connected to a charged fixed electrode and makes contact with the electrode plates at different positions as it moves with the piston, thereby detecting the position of the piston.

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