A cerebral autoregulation monitoring device

Abstract

The application discloses a cerebral blood flow autoregulation monitoring device and relates to the technical field of medical monitoring.The device comprises a left brain impedance measuring component, a right brain impedance measuring component, a continuous blood pressure monitoring module, a multi-channel data synchronous acquisition card, a computer processing system, a head-mounted fixing mechanism and a rack.The left brain impedance measuring component and the right brain impedance measuring component are used for independently collecting the brain impedance signals of the left and right cerebral hemispheres respectively, the continuous blood pressure monitoring module is used for collecting the continuous beat-by-beat arterial blood pressure signals of a patient in real time, the multi-channel data synchronous acquisition card is used for synchronously collecting the left brain impedance signals, the right brain impedance signals and the continuous blood pressure signals and then transmitting the signals to the computer processing system, and the computer processing system is used for calculating the cerebral blood flow autoregulation parameters of the left brain and the right brain respectively, so that the problem that the existing wearable device cannot synchronously and independently acquire the CA function information of the left and right cerebral hemispheres is effectively solved.

Description

Technical Field

[0001] This invention relates to the field of medical monitoring technology, and in particular to an automatic cerebral blood flow regulation and monitoring device. Background Technology

[0002] Cerebral autoregulation (CA) refers to the physiological mechanism by which tiny arteries in the brain maintain relatively stable cerebral blood flow by constricting or dilating when arterial blood pressure fluctuates within a certain range. It is one of the core functions of the brain's self-protection. Clinically, the assessment of CA function is of significant guiding value for the diagnosis and treatment of severe neurological diseases such as acute ischemic stroke, traumatic brain injury, and subarachnoid hemorrhage.

[0003] In existing technologies, such as the cerebral blood flow automatic regulation monitoring device disclosed in patent CN108703773A, the simultaneous acquisition and real-time analysis of cerebral blood flow and blood pressure data is achieved by integrating a transcranial Doppler ultrasound (TCD) plate and a continuous blood pressure device, representing a significant improvement over traditional split-type devices. However, such devices mainly rely on single-channel TCD technology to monitor cerebral blood flow velocity, and can only acquire unilateral or global CA functional status. They cannot simultaneously and independently acquire CA functional information from the left and right cerebral hemispheres, and it is even more difficult to quantitatively assess bilateral CA functional asymmetry. In addition, the inherent defects of TCD technology, such as high operator dependence, difficulty in probe fixation, and susceptibility to signal interference, also limit its reliability in long-term, dynamic monitoring scenarios. Summary of the Invention

[0004] This invention provides an automatic cerebral blood flow regulation and monitoring device, which can solve the problem that existing wearable devices cannot synchronously and independently acquire CA function information of the left and right cerebral hemispheres, and it is even more difficult to achieve quantitative assessment of bilateral CA function asymmetry.

[0005] An automatic cerebral blood flow regulation monitoring device includes a left brain impedance measurement component, a right brain impedance measurement component, a continuous blood pressure monitoring module, a multi-channel data synchronous acquisition card, a computer processing system, a head-mounted fixation mechanism, and a stand. The left brain impedance measurement component is used to independently acquire brain impedance signals from the left cerebral hemisphere; the right brain impedance measurement component is used to independently acquire brain impedance signals from the right cerebral hemisphere; the continuous blood pressure monitoring module is used to acquire the patient's continuous beat-by-beat arterial blood pressure signals in real time; the multi-channel data synchronous acquisition card is electrically connected to the left brain impedance measurement component, the right brain impedance measurement component, and the continuous blood pressure monitoring module, respectively, for synchronously acquiring left brain impedance signals, right brain impedance signals, and continuous blood pressure signals; the computer processing system is electrically connected to the multi-channel data synchronous acquisition card, for receiving the synchronously acquired signals, calculating the automatic cerebral blood flow regulation parameters of the left and right hemispheres respectively, and calculating the asymmetry index based on the bilateral automatic regulation parameters to generate a comparative analysis result of the bilateral automatic cerebral blood flow regulation function; the head-mounted fixation mechanism is connected to the left brain impedance measurement component and the right brain impedance measurement component; the stand is connected to the computer processing system.

[0006] The present invention provides an automatic cerebral blood flow regulation and monitoring device, which, compared with the prior art, has, but is not limited to, the following beneficial effects: This automatic brain blood flow regulation monitoring device independently acquires brain impedance signals from the left and right cerebral hemispheres through left and right brain impedance measurement components, respectively. A continuous blood pressure monitoring module collects the patient's continuous beat-by-beat arterial blood pressure signals in real time. The left and right brain impedance signals, along with the continuous blood pressure signals, are then simultaneously acquired by a multi-channel data acquisition card and transmitted to a computer processing system. The computer processing system calculates the automatic brain blood flow regulation parameters for the left and right hemispheres, calculates the asymmetry index based on the bilateral automatic regulation parameters, and generates a comparative analysis of the bilateral automatic brain blood flow regulation function. Simultaneously, a head-mounted fixation mechanism is connected to the left and right brain impedance measurement components to ensure stable electrode contact, and a frame is connected to the computer processing system to support the overall structure. This effectively solves the problem that existing wearable devices cannot synchronously and independently acquire CA function information from the left and right cerebral hemispheres, and even more so, it is difficult to quantitatively assess the asymmetry of bilateral CA function.

[0007] Furthermore, the left brain impedance measurement component includes a first constant current excitation source, a first excitation current electrode, and a first voltage detection electrode. The first constant current excitation source is electrically connected to the first excitation current electrode, the first voltage detection electrode is electrically connected to a first biological voltage amplifier, and the first biological voltage amplifier is electrically connected to a first demodulation and impedance calculation unit.

[0008] Furthermore, the right brain impedance measurement component includes a second constant current excitation source, a second excitation current electrode, and a second voltage detection electrode. The second constant current excitation source is electrically connected to the second excitation current electrode, the second voltage detection electrode is electrically connected to the second bio-voltage amplifier, and the second bio-voltage amplifier is electrically connected to the second demodulation and impedance calculation unit.

[0009] Furthermore, the first excitation current electrode and the first voltage detection electrode of the left brain impedance measurement component adopt a four-electrode layout, including a pair of excitation current injection electrodes and a pair of voltage detection electrodes. The two pairs of electrodes are attached to the skin surface of the frontotemporal region corresponding to the left cerebral hemisphere without overlapping. The second excitation current electrode and the second voltage detection electrode of the right brain impedance measurement component are attached to the skin surface of the frontotemporal region corresponding to the right cerebral hemisphere with the midsagittal plane of the brain as a symmetrical mirror image.

[0010] Furthermore, the head-mounted fixation mechanism includes an adjustable circumference contraction ring, a fixing strap is provided on the contraction ring, a cushioning sponge pad is provided on the inner side of the contraction ring, and the electrode groups of the left brain impedance measurement component and the right brain impedance measurement component are fixedly arranged on the inner side of the contraction ring corresponding to the temporal window positions on both sides.

[0011] Furthermore, the shrink ring is provided with a probe fixing base, the probe fixing base is embedded with a slot structure for accommodating and positioning the electrode assembly, and the probe fixing base and the shrink ring are connected by a universal adjustment joint to adjust the contact angle and pressure between the electrode assembly and the scalp.

[0012] Furthermore, the continuous blood pressure monitoring module includes a finger-type non-invasive continuous blood pressure sensor, an altitude correction component, and a blood pressure signal processing unit. The blood pressure signal processing unit is electrically connected to the finger-type non-invasive continuous blood pressure sensor and the altitude correction component, respectively, and is used to receive pressure waveforms and altitude compensation signals and generate corrected brachial artery continuous blood pressure data. The height correction component includes a reference sensor positioned at the same level as the heart and a transducer mounted on a finger-type non-invasive continuous blood pressure sensor, used to acquire the vertical distance between the finger and the heart and to perform height compensation on the blood pressure measurement.

[0013] Furthermore, the computer processing system includes a signal preprocessing module, a feature extraction module, an automatic adjustment parameter calculation module, an asymmetry analysis module, and a visualization output module. The signal preprocessing module is used to perform wavelet denoising and adaptive filtering on the left brain impedance signal, right brain impedance signal, and continuous blood pressure signal. The feature extraction module is used to extract the impedance pulse amplitude, waveform rise time, P2 / P1 ratio, and baseline impedance value from the denoised left and right brain impedance signals, respectively. The automatic adjustment parameter calculation module is used to calculate the phase difference, consistency, gain, and automatic adjustment index of the left and right brain, respectively, based on transfer function analysis. The asymmetry analysis module is used to calculate the asymmetry index. The visualization output module is used to generate and display a histogram, trend curve, and dynamic change spectrum of the asymmetry index for the bilateral automatic adjustment parameters.

[0014] Furthermore, it also includes an audible and visual alarm module, which is integrated and installed on a stand and electrically connected to a computer processing system; when the asymmetry index is greater than a preset threshold and the duration exceeds a set time window, or when the automatic regulation index of cerebral blood flow on either side is lower than a safety threshold, the audible and visual alarm module triggers an audible and visual warning prompt.

[0015] Furthermore, it also includes an ultraviolet sterilization and disinfection box, which is fixed on a stand. The ultraviolet sterilization and disinfection box is equipped with an ultraviolet disinfection lamp, a first placement tray and a second placement tray inside. The first placement tray is used to place a finger-type non-invasive continuous blood pressure sensor, and the second placement tray is used to place a headband fixation mechanism. The ultraviolet sterilization and disinfection box is provided with a first sealing door and a second sealing door on both sides. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of an automatic cerebral blood flow regulation and monitoring device according to an embodiment of the present invention; Figure 2 This is a schematic flowchart of an embodiment of the cerebral blood flow automatic regulation and monitoring device of the present invention; Figure 3 for Figure 1 Flowchart of the continuous blood pressure monitoring module; Figure 4 for Figure 1 Schematic diagram of the head-mounted fixation mechanism; Figure 5 for Figure 1 A schematic diagram of the structure of a UV sterilization and disinfection box.

[0017] Explanation of reference numerals in the attached figures: 1. Left brain impedance measurement component; 2. Right brain impedance measurement component; 3. Continuous blood pressure monitoring module; 4. Multi-channel data synchronous acquisition card; 5. Computer processing system; 6. Head-mounted fixation mechanism; 7. Stand; 8. Audible and visual alarm module; 9. Ultraviolet sterilization and disinfection box; 10. Ultraviolet disinfection lamp; 11. First placement tray; 12. Second placement tray; 101. First constant current excitation source; 102. First excitation current electrode; 103. First voltage detection electrode; 104. First bio-voltage amplifier; 105. First demodulation and impedance calculation unit; 201. Second constant current excitation source; 202. Second excitation current electrode; 203. 1. Second voltage detection electrode; 204. Second bio-voltage amplifier; 205. Second demodulation and impedance calculation unit; 31. Finger-type non-invasive continuous blood pressure sensor; 32. Height correction component; 33. Blood pressure signal processing unit; 321. Reference sensor; 322. Transducer; 51. Signal preprocessing module; 52. Feature extraction module; 53. Automatic adjustment parameter calculation module; 54. Asymmetry analysis module; 55. Visualization output module; 61. Contraction ring; 62. Fixing strap; 63. Buffer sponge pad; 64. Probe fixing base; 65. Universal adjustment joint; 91. First sealing door plate; 92. Second sealing door plate. Detailed Implementation

[0018] To make the objectives, technical solutions, and advantages of this application clearer, specific embodiments of this application are described clearly and completely below with reference to the accompanying drawings. It should be understood that the described embodiments are only a part of the embodiments of this application, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments described in this application without creative effort will fall within the scope of protection of this application.

[0019] Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains; the terminology used in the specification of this application is for the purpose of describing specific embodiments only and is not intended to limit this application; the terms "comprising," "including," "having," "containing," "comprise," etc., in the specification, claims, and accompanying drawings of this application are open-ended terms, indicating that a method comprises one or more steps, or an apparatus comprises one or more elements, but do not exclude the inclusion of other steps or elements. The terms "first," "second," etc., in the specification, claims, or accompanying drawings of this application are used to distinguish different objects, not to describe a specific order or primary / secondary relationship. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0020] In the description of this application, it should be understood that the terms "upper", "lower", "left", "right", "front", "rear", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0021] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "attachment" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0022] In this application, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. Additionally, in this application, the character " / " generally indicates that the preceding and following related objects have an "or" relationship.

[0023] like Figure 1As shown in the figure, an automatic cerebral blood flow regulation and monitoring device provided in this embodiment of the invention includes a left brain impedance measurement component 1, a right brain impedance measurement component 2, a continuous blood pressure monitoring module 3, a multi-channel data synchronization acquisition card 4, a computer processing system 5, a head-mounted fixation mechanism 6, and a stand 7. The left brain impedance measurement component 1 is used to independently acquire brain impedance signals from the left cerebral hemisphere; the right brain impedance measurement component 2 is used to independently acquire brain impedance signals from the right cerebral hemisphere; the continuous blood pressure monitoring module 3 is used to acquire the patient's continuous beat-by-beat arterial blood pressure signals in real time; the multi-channel data synchronization acquisition card 4 is connected to the left brain impedance measurement component 1. Component 1, right brain impedance measurement component 2, and continuous blood pressure monitoring module 3 are electrically connected to synchronously acquire left brain impedance signals, right brain impedance signals, and continuous blood pressure signals; computer processing system 5 is electrically connected to multi-channel data synchronous acquisition card 4 to receive synchronously acquired signals, calculate the automatic regulation parameters of cerebral blood flow in the left and right brains respectively, and calculate the asymmetry index based on the bilateral automatic regulation parameters to generate comparative analysis results of bilateral cerebral blood flow automatic regulation function; head-mounted fixation mechanism 6 is connected to left brain impedance measurement component 1 and right brain impedance measurement component 2; and stand 7 is connected to computer processing system 5.

[0024] In this embodiment, the left and right cerebral impedance measurement components 1 and 2 independently acquire the cerebral impedance signals of the left and right cerebral hemispheres, respectively. The continuous blood pressure monitoring module 3 acquires the patient's continuous pulse-by-pulse arterial blood pressure signal in real time. The left and right cerebral impedance signals and the continuous blood pressure signal are then simultaneously acquired by the multi-channel data synchronization acquisition card 4 and transmitted to the computer processing system 5. The computer processing system 5 calculates the autoregulation parameters of cerebral blood flow in the left and right hemispheres, respectively, and calculates the asymmetry index based on the bilateral autoregulation parameters, generating a comparative analysis result of the bilateral cerebral blood flow autoregulation function. At the same time, the head-mounted fixation mechanism 6 is connected to the left and right cerebral impedance measurement components 1 and 2 to ensure stable electrode contact. The frame 7 is connected to the computer processing system 5 to support the overall structure. This effectively solves the problem that existing wearable devices cannot synchronously and independently acquire CA function information of the left and right cerebral hemispheres, and it is even more difficult to quantitatively assess the asymmetry of bilateral CA function. It realizes accurate comparative analysis and asymmetry quantification of bilateral cerebral blood flow autoregulation function, providing a reliable basis for the diagnosis and individualized treatment of unilateral cerebrovascular diseases.

[0025] like Figure 1 and Figure 2 As shown, the left brain impedance measurement component 1 includes a first constant current excitation source 101, a first excitation current electrode 102 and a first voltage detection electrode 103. The first constant current excitation source 101 is electrically connected to the first excitation current electrode 102, the first voltage detection electrode 103 is electrically connected to the first biological voltage amplifier 104, and the first biological voltage amplifier 104 is electrically connected to the first demodulation and impedance calculation unit 105.

[0026] In this embodiment, the left brain impedance measurement component 1 outputs a highly stable microampere-level constant current excitation current to the first excitation current electrode 102 through the first constant current excitation source 101. After the current is injected into the left cerebral hemisphere, a potential difference is generated on the brain tissue impedance. The potential difference signal is picked up by the first voltage detection electrode 103, and then amplified by the first bio-voltage amplifier 104 with high gain and low noise. Finally, the first demodulation and impedance calculation unit 105 demodulates the basic impedance value and impedance pulsation waveform reflecting the pulsatility change of the left brain blood flow, thereby realizing the independent, accurate and stable acquisition of the left hemisphere brain impedance signal, effectively avoiding external interference and signal crosstalk, and providing a high-quality unilateral data basis for subsequent comparative analysis and asymmetry assessment of bilateral cerebral blood flow automatic regulation parameters.

[0027] like Figure 1 and Figure 2 As shown, the right brain impedance measurement component 2 includes a second constant current excitation source 201, a second excitation current electrode 202, and a second voltage detection electrode 203. The second constant current excitation source 201 is electrically connected to the second excitation current electrode 202, the second voltage detection electrode 203 is electrically connected to the second bio-voltage amplifier 204, and the second bio-voltage amplifier 204 is electrically connected to the second demodulation and impedance calculation unit 205.

[0028] In this embodiment, the right brain impedance measurement component 2 outputs a highly stable microampere-level constant current excitation current to the second excitation current electrode 202 through the second constant current excitation source 201. After the current is injected into the right cerebral hemisphere, a potential difference is generated on the brain tissue impedance. The potential difference signal is picked up by the second voltage detection electrode 203, and then amplified by the second bio-voltage amplifier 204 with high gain and low noise. Finally, the second demodulation and impedance calculation unit 205 demodulates the basic impedance value and impedance pulsation waveform reflecting the pulsatility change of the right brain blood flow, thereby realizing the independent, accurate and stable acquisition of the right hemisphere brain impedance signal. It cooperates with the left brain impedance measurement component 1 without interfering with each other, and provides symmetrical and comparable right brain data support for the independent calculation and asymmetry analysis of bilateral cerebral blood flow automatic regulation parameters.

[0029] like Figure 1 As shown, the first excitation current electrode 102 and the first voltage detection electrode 103 of the left brain impedance measurement component 1 adopt a four-electrode layout, including a pair of excitation current injection electrodes and a pair of voltage detection electrodes. The two pairs of electrodes are attached to the skin surface of the frontotemporal region corresponding to the left cerebral hemisphere without overlapping. The second excitation current electrode 202 and the second voltage detection electrode 203 of the right brain impedance measurement component 2 are attached to the skin surface of the frontotemporal region corresponding to the right cerebral hemisphere with the midsagittal plane of the brain as a symmetrical mirror image.

[0030] In this embodiment, by using the same four-electrode layout attached to the skin surface of the frontotemporal region corresponding to the right cerebral hemisphere, this symmetrical mirror four-electrode layout effectively eliminates the interference of contact impedance between the excitation current injection electrode and the voltage detection electrode on the measurement signal, improving the signal-to-noise ratio and accuracy of brain impedance measurement. At the same time, the completely symmetrical attachment method on both sides ensures a high degree of consistency in the measurement conditions on both sides, making the asymmetry index calculated based on the bilateral autoregulation parameters more comparable and clinically valuable. This provides a reliable hardware foundation for accurately identifying the responsible side of unilateral cerebrovascular lesions and assessing the differences in bilateral autoregulation functions.

[0031] like Figure 1 and Figure 4 As shown, the head-mounted fixation mechanism 6 includes an adjustable circumference contraction ring 61, a fixing strap 62 is provided on the contraction ring 61, a cushioning sponge pad 63 is provided on the inner side of the contraction ring 61, and the electrode groups of the left brain impedance measurement component 1 and the right brain impedance measurement component 2 are fixedly installed on the inner side of the contraction ring 61 corresponding to the temporal window positions on both sides.

[0032] In this embodiment, the head-mounted fixation mechanism 6, through an adjustable circumference contraction ring 61, can adapt to the head circumference sizes of different patients, ensuring universality and stability of wearing. The fixation strap 62 provided on the contraction ring 61 further enhances the overall fixation reliability and prevents displacement during monitoring. The buffer sponge pad 63 provided on the inner side of the contraction ring 61 effectively buffers the wearing pressure and improves the patient's comfort. At the same time, the electrode groups of the left brain impedance measurement component 1 and the right brain impedance measurement component 2 are fixedly set on the inner side of the contraction ring 61 corresponding to the temporal window positions on both sides, ensuring that the electrode groups can be accurately and stably attached to the preset measurement positions of the bilateral frontotemporal skin, avoiding signal artifacts caused by electrode displacement or loosening, thereby ensuring long-term stable acquisition of bilateral brain impedance signals and providing structural support for continuous and reliable automatic regulation monitoring of cerebral blood flow.

[0033] like Figure 1 and Figure 4 As shown, a probe fixing base 64 is provided on the shrink ring 61. The probe fixing base 64 has a slot structure for accommodating and positioning the electrode assembly. The probe fixing base 64 and the shrink ring 61 are connected by a universal adjustment joint 65 to adjust the contact angle and pressure between the electrode assembly and the scalp.

[0034] In this embodiment, the probe fixing base 64 on the contraction ring 61 precisely accommodates and positions the electrode groups of the left brain impedance measurement component 1 and the right brain impedance measurement component 2 through the embedded slot structure, ensuring that the electrode groups are always in the preset temporal window position during the measurement process. At the same time, the probe fixing base 64 and the contraction ring 61 are connected by a universal adjustment joint 65, which can flexibly adjust the contact angle and pressure between the electrode group and the scalp according to the individual curvature and contour of the patient's head, so that the electrode group maintains uniform and stable contact with the skin, which effectively avoids the increase in contact impedance and signal attenuation caused by poor contact.

[0035] like Figure 2 and Figure 3 As shown, the continuous blood pressure monitoring module 3 includes a finger-type non-invasive continuous blood pressure sensor 31, a height correction component 32, and a blood pressure signal processing unit 33. The blood pressure signal processing unit 33 is electrically connected to the finger-type non-invasive continuous blood pressure sensor 31 and the height correction component 32, respectively, and is used to receive pressure waveforms and height compensation signals and generate corrected brachial artery continuous blood pressure data. The height correction component 32 includes a reference sensor 321 set at the same level as the heart and a transducer 322 set on the finger-type non-invasive continuous blood pressure sensor 31, and is used to collect the vertical distance between the finger and the heart and perform height compensation on the blood pressure measurement value.

[0036] In this embodiment, the continuous blood pressure monitoring module 3 acquires the finger arterial pressure waveform in real time through the finger-type non-invasive continuous blood pressure sensor 31. At the same time, the reference sensor 321 and transducer 322 in the height correction component 32 accurately acquire the vertical distance between the finger and the heart. The blood pressure signal processing unit 33 receives the pressure waveform and the height compensation signal respectively, and performs real-time height compensation on the blood pressure measurement value according to the vertical distance to generate corrected brachial artery continuous blood pressure data. This effectively eliminates the blood pressure measurement error caused by the height difference between the arm and the heart, ensuring the accuracy and reliability of the synchronously acquired continuous blood pressure signal. It provides high-quality blood pressure reference data for subsequent transfer function analysis with left and right brain impedance signals and calculation of automatic regulation parameters of cerebral blood flow.

[0037] Among them, the finger-type non-invasive continuous blood pressure sensor 31, the height correction component 32, and the blood pressure signal processing unit 33 are all existing components.

[0038] like Figure 1 and Figure 2As shown, the computer processing system 5 includes a signal preprocessing module 51, a feature extraction module 52, an automatic adjustment parameter calculation module 53, an asymmetry analysis module 54, and a visualization output module 55. The signal preprocessing module 51 is used to perform wavelet denoising and adaptive filtering on the left brain impedance signal, the right brain impedance signal, and the continuous blood pressure signal. The feature extraction module 52 is used to extract the impedance pulse amplitude, waveform rise time, P2 / P1 ratio, and baseline impedance value from the denoised left and right brain impedance signals, respectively. The automatic adjustment parameter calculation module 53 is used to calculate the phase difference, consistency, gain, and automatic adjustment index of the left and right brain, respectively, based on transfer function analysis. The asymmetry analysis module 54 is used to calculate the asymmetry index. The visualization output module 55 is used to generate and display the histogram comparison chart, trend curve chart, and dynamic change spectrum of the asymmetry index of the bilateral automatic adjustment parameters.

[0039] In this embodiment, the computer processing system 5 performs wavelet denoising and adaptive filtering on the left brain impedance signal, right brain impedance signal, and continuous blood pressure signal through the signal preprocessing module 51, effectively suppressing body movement, respiration, and power frequency interference, and significantly improving signal quality. The feature extraction module 52 extracts the impedance pulse amplitude, waveform rise time, P2 / P1 ratio, and baseline impedance value from the denoised left and right brain impedance signals, respectively, providing rich time-domain features for the assessment of automatic regulation of cerebral blood flow. The automatic regulation parameter calculation module 53 calculates the phase difference, consistency, gain, and other parameters of the left and right brain based on transfer function analysis. The autoregulation index enables the quantitative characterization of bilateral cerebral blood flow autoregulation function; the asymmetry analysis module 54 calculates the asymmetry index to intuitively quantify the degree of difference in bilateral autoregulation function; the visualization output module 55 generates and displays the bar charts, trend curves, and dynamic change graphs of bilateral autoregulation parameters, thereby presenting the complex bilateral physiological signal processing results in an intuitive and dynamic graphical manner. This facilitates clinicians to quickly identify unilateral autoregulation function impairment and bilateral differences, providing direct and visualized quantitative evidence for the accurate diagnosis and individualized treatment decisions of unilateral cerebrovascular diseases.

[0040] like Figure 1 As shown, it also includes an audible and visual alarm module 8, which is integrated and installed on the stand 7 and electrically connected to the computer processing system 5. When the asymmetry index is greater than the preset threshold and the duration exceeds the set time window, or when the automatic regulation index of blood flow on either side of the brain is lower than the safety threshold, the audible and visual alarm module 8 triggers an audible and visual warning.

[0041] In this embodiment, the audible and visual alarm module 8 is integrated and installed on the stand 7 and electrically connected to the computer processing system 5. It can receive the monitoring parameters generated by the computer processing system 5 in real time. When the asymmetry index is greater than the preset threshold and the duration exceeds the set time window, or when the autoregulation index of cerebral blood flow on either side is lower than the safety threshold, the audible and visual alarm module 8 immediately triggers an audible and visual warning, thereby realizing real-time and automatic monitoring and abnormal warning of the status of bilateral cerebral blood flow autoregulation function. This effectively avoids the delayed identification that may be caused by continuous manual observation of data by clinicians, and helps to promptly remind clinical intervention when there is significant asymmetry in bilateral autoregulation function or severe damage on one side.

[0042] like Figure 1 and Figure 5 As shown, it also includes an ultraviolet sterilization and disinfection box 9, which is fixed on the frame 7. The ultraviolet sterilization and disinfection box 9 is equipped with an ultraviolet disinfection lamp 10, a first placement tray 11 and a second placement tray 12. The first placement tray 11 is used to place a finger-type non-invasive continuous blood pressure sensor 31, and the second placement tray 12 is used to place a headband-type fixation mechanism 6. The ultraviolet sterilization and disinfection box 9 is equipped with a first sealing door panel 91 and a second sealing door panel 92 on both sides.

[0043] In this embodiment, the ultraviolet sterilization box 9 is fixed on the stand 7. The ultraviolet disinfection lamp 10 installed inside can efficiently sterilize the finger-type non-invasive continuous blood pressure sensor 31 placed on the first placement tray 11 and the head-mounted fixation mechanism 6 placed on the second placement tray 12. The first sealing door 91 and the second sealing door 92 respectively set on both sides of the ultraviolet sterilization box 9 facilitate the handling of equipment components from different directions, while maintaining the airtightness during the sterilization process. This effectively eliminates the risk of cross-infection that may occur when different patients reuse the above-mentioned components that come into direct contact with the skin, ensuring the hygiene and safety of clinical use and extending the service life of the equipment.

[0044] The above-disclosed embodiments are merely a few specific examples of the present invention. However, the embodiments of the present invention are not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A device for automatically regulating and monitoring cerebral blood flow, characterized in that, include: Left brain impedance measurement component (1), used to independently acquire brain impedance signals from the left cerebral hemisphere; Right brain impedance measurement component (2), used to independently collect brain impedance signals from the right cerebral hemisphere; The continuous blood pressure monitoring module (3) is used to collect the patient's continuous beat-by-beat arterial blood pressure signal in real time; The multi-channel data synchronous acquisition card (4) is electrically connected to the left brain impedance measurement component (1), the right brain impedance measurement component (2) and the continuous blood pressure monitoring module (3) respectively, and is used to synchronously acquire left brain impedance signals, right brain impedance signals and continuous blood pressure signals. The computer processing system (5) is electrically connected to the multi-channel data synchronous acquisition card (4) to receive synchronously acquired signals, calculate the automatic regulation parameters of cerebral blood flow in the left and right hemispheres respectively, and calculate the asymmetry index based on the bilateral automatic regulation parameters to generate a comparative analysis result of the bilateral cerebral blood flow automatic regulation function. The head-mounted fixation mechanism (6) is connected to the left brain impedance measurement component (1) and the right brain impedance measurement component (2); The stand (7) is connected to the computer processing system (5).

2. The automatic cerebral blood flow regulation and monitoring device as described in claim 1, characterized in that, The left brain impedance measurement component (1) includes a first constant current excitation source (101), a first excitation current electrode (102) and a first voltage detection electrode (103). The first constant current excitation source (101) is electrically connected to the first excitation current electrode (102), the first voltage detection electrode (103) is electrically connected to the first biological voltage amplifier (104), and the first biological voltage amplifier (104) is electrically connected to the first demodulation and impedance calculation unit (105).

3. The automatic cerebral blood flow regulation and monitoring device as described in claim 2, characterized in that, The right brain impedance measurement component (2) includes a second constant current excitation source (201), a second excitation current electrode (202), and a second voltage detection electrode (203). The second constant current excitation source (201) is electrically connected to the second excitation current electrode (202), the second voltage detection electrode (203) is electrically connected to the second biological voltage amplifier (204), and the second biological voltage amplifier (204) is electrically connected to the second demodulation and impedance calculation unit (205).

4. The automatic cerebral blood flow regulation and monitoring device as described in claim 3, characterized in that, The first excitation current electrode (102) and the first voltage detection electrode (103) of the left brain impedance measurement component (1) adopt a four-electrode layout, including a pair of excitation current injection electrodes and a pair of voltage detection electrodes. The two pairs of electrodes are attached to the skin surface of the frontotemporal region corresponding to the left cerebral hemisphere without overlapping. The second excitation current electrode (202) and the second voltage detection electrode (203) of the right brain impedance measurement component (2) are attached to the skin surface of the frontotemporal region corresponding to the right cerebral hemisphere with the same four-electrode layout, with the midsagittal plane of the brain as a symmetrical mirror image.

5. The automatic cerebral blood flow regulation and monitoring device as described in claim 1, characterized in that, The head-mounted fixation mechanism (6) includes an adjustable circumference contraction ring (61), a fixing strap (62) is provided on the contraction ring (61), a cushioning sponge pad (63) is provided on the inner side of the contraction ring (61), and the electrode groups of the left brain impedance measurement component (1) and the right brain impedance measurement component (2) are fixedly arranged on the inner side of the contraction ring (61) at the corresponding temporal window positions on both sides.

6. The automatic cerebral blood flow regulation and monitoring device as described in claim 5, characterized in that, The shrink ring (61) is provided with a probe fixing base (64), the probe fixing base (64) is embedded with a slot structure for accommodating and positioning the electrode group, and the probe fixing base (64) and the shrink ring (61) are connected by a universal adjustment joint (65) to adjust the contact angle and pressure between the electrode group and the scalp.

7. The automatic cerebral blood flow regulation and monitoring device as described in claim 1, characterized in that, The continuous blood pressure monitoring module (3) includes a finger-type non-invasive continuous blood pressure sensor (31), an altitude correction component (32), and a blood pressure signal processing unit (33). The blood pressure signal processing unit (33) is electrically connected to the finger-type non-invasive continuous blood pressure sensor (31) and the altitude correction component (32) respectively, and is used to receive pressure waveforms and altitude compensation signals and generate corrected brachial artery continuous blood pressure data. The height correction component (32) includes a reference sensor (321) positioned at the same height as the heart and a transducer (322) positioned on a finger-type non-invasive continuous blood pressure sensor (31) for acquiring the vertical distance between the finger and the heart and for height compensation of the blood pressure measurement value.

8. The automatic cerebral blood flow regulation and monitoring device as described in claim 1, characterized in that, The computer processing system (5) includes a signal preprocessing module (51), a feature extraction module (52), an automatic adjustment parameter calculation module (53), an asymmetry analysis module (54), and a visualization output module (55). The signal preprocessing module (51) is used to perform wavelet denoising and adaptive filtering on the left brain impedance signal, the right brain impedance signal, and the continuous blood pressure signal. The feature extraction module (52) is used to extract the impedance pulse amplitude, waveform rise time, P2 / P1 ratio, and basic impedance value from the denoised left and right brain impedance signals, respectively. The automatic adjustment parameter calculation module (53) is used to calculate the phase difference, consistency, gain, and automatic adjustment index of the left and right brain, respectively, based on transfer function analysis. The asymmetry analysis module (54) is used to calculate the asymmetry index. The visualization output module (55) is used to generate and display the bar chart, trend curve, and dynamic change spectrum of the asymmetry index of the bilateral automatic adjustment parameters.

9. The automatic cerebral blood flow regulation and monitoring device as described in claim 8, characterized in that, It also includes an audible and visual alarm module (8), which is integrated and installed on the stand (7) and electrically connected to the computer processing system (5); when the asymmetry index is greater than the preset threshold and the duration exceeds the set time window, or when the automatic regulation index of blood flow on either side of the brain is lower than the safety threshold, the audible and visual alarm module (8) triggers an audible and visual warning prompt.

10. The automatic cerebral blood flow regulation and monitoring device as described in claim 1, characterized in that, It also includes an ultraviolet sterilization and disinfection box (9), which is fixed on a stand (7). The ultraviolet sterilization and disinfection box (9) is equipped with an ultraviolet disinfection lamp (10), a first placement tray (11) and a second placement tray (12) inside. The first placement tray (11) is used to place a finger-type non-invasive continuous blood pressure sensor (31), and the second placement tray (12) is used to place a headband-type fixation mechanism (6). The ultraviolet sterilization and disinfection box (9) is equipped with a first sealing door panel (91) and a second sealing door panel (92) on both sides.

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