A toothpaste and a method of making the same

Abstract

This invention discloses a toothpaste comprising the following components in parts by weight: chlorhexidine gluconate 0.2-2, traditional Chinese medicine extract 5-15, menthol 0.5-1.0, abrasive 16-55, humectant 40-80, cocamidopropyl betaine 4-10, hydroxyethyl cellulose 0.5-1, xanthan gum 0.5-2, chelating agent 0.1-0.6, preservative 0.24-1, and purified water 12.96-20.04. This invention also provides a method for preparing this toothpaste. The chlorhexidine gluconate in the toothpaste provided by this invention has the effect of inhibiting and killing Gram-positive and Gram-negative bacteria in the oral cavity, effectively inhibiting dental plaque and controlling gingivitis and periodontitis. Menthol contributes to the cooling taste and fresh scent of the toothpaste, and also has a certain antibacterial effect. It can simultaneously inhibit oral inflammation and kill pathogenic bacteria such as dental plaque, effectively improving oral health.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, and more specifically, to a toothpaste and its preparation method. Background Technology

[0002] Toothpaste is an essential daily necessity. It cleans teeth and surrounding tissues through the mechanical friction of a toothbrush, keeping teeth clean and healthy. Common oral diseases include gingivitis, periodontitis, and periodontal disease, as well as oral ulcers. Gingivitis manifests as bleeding, swelling, and pain in the gums. If it progresses and invades hard tissues, it can lead to periodontitis, which includes inflammation of the gum tissue. When brushing or eating, the inflamed gums bleed easily due to mechanical stimulation. Periodontal disease is caused by dental plaque. Dental plaque is a soft, unmineralized colony of bacteria that adhere to each other, or adhere to the tooth surface, interdental spaces, or restoration surfaces, encased in a matrix.

[0003] Therefore, how to suppress inflammation and effectively kill pathogens is of great significance to oral health and hygiene. Summary of the Invention

[0004] To address the aforementioned deficiencies, the present invention provides a toothpaste and its preparation method to resolve the technical problems existing in the background art.

[0005] This invention provides a toothpaste comprising the following components in parts by weight: chlorhexidine gluconate 0.2-2, traditional Chinese medicine extract 5-15, menthol 0.5-1.0, abrasive 16-55, humectant 40-80, cocamidopropyl betaine 4-10, hydroxyethyl cellulose 0.5-1, xanthan gum 0.5-2, chelating agent 0.1-0.6, preservative 0.24-1, and purified water 12.96-20.04.

[0006] Preferably, the herbal extract includes one or more of dandelion, thistle, and Panax notoginseng.

[0007] Preferably, the herbal extract includes dandelion, thistle, and Panax notoginseng; the mass ratio of dandelion, thistle, and Panax notoginseng is 1-2:2-4:1-5.

[0008] Preferably, the preservative includes methylparaben and / or propylparaben.

[0009] Preferably, the preservative comprises methylparaben and propylparaben; the mass ratio of methylparaben to propylparaben is 1-2:1-5.

[0010] Preferably, the friction agent comprises: cobalt salt and / or silicon dioxide.

[0011] Preferably, the friction agent comprises: cobalt salt and silicon dioxide; wherein the mass ratio of the cobalt salt and the silicon dioxide is 1-10:15-45.

[0012] Preferably, the moisturizer comprises sorbitol and / or glycerin.

[0013] Preferably, the moisturizer comprises sorbitol and glycerin, wherein the mass ratio of sorbitol to glycerin is 30-50:10-30.

[0014] A method for preparing toothpaste, characterized in that the method comprises the following steps:

[0015] S1. Weigh the purified water according to the formula and add it to the vacuum ointment making pot. Heat the temperature to 40-75°C, add the chelating agent, and stir until completely dissolved.

[0016] S2. Add hydroxyethyl cellulose, xanthan gum, sorbitol and glycerin to the solution in sequence, and stir continuously for 20-30 minutes until completely dissolved to obtain a paste;

[0017] S3. Then add silica and cobalt salt to the vacuum paste-making pot; and stir under vacuum for 15-20 minutes to evenly disperse the silica particles and cobalt salt in the paste.

[0018] S4. Cool the paste to 40-45°C, then add cocamidopropyl betaine and menthol in sequence, and stir well.

[0019] S5. Then lower the temperature by 5-10℃, add chlorhexidine gluconate, traditional Chinese medicine extract and preservative in sequence, stir for 10-20 minutes, and then continue stirring for 15-40 minutes under vacuum to obtain the finished product.

[0020] The beneficial effects of the toothpaste and its preparation method provided by this invention are as follows: Chlorhexidine gluconate has the effect of inhibiting and killing Gram-positive and Gram-negative bacteria in the oral cavity, effectively inhibiting dental plaque and controlling gingivitis and periodontitis. Menthol is used for the cooling taste and fresh scent of the toothpaste, and also has a certain antibacterial effect. Cocamidopropyl betaine is used to generate foam. Hydroxyethyl cellulose has a thickening effect. Xanthan gum is used to make the toothpaste stand stably on the toothbrush, and it can be thinned and easily dispersed in the mouth by shearing. Chelating agents are used to chelate calcium and magnesium ions in water, reducing the interference of hard water on foaming. It can simultaneously inhibit oral inflammation and kill pathogenic bacteria such as dental plaque, effectively improving oral health. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this patent, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a flowchart illustrating the toothpaste preparation method according to an embodiment of the present invention. Detailed Implementation

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] The toothpaste provided by the present invention will now be described. The toothpaste comprises the following components in parts by weight: chlorhexidine gluconate 0.2-2, traditional Chinese medicine extract 5-15, menthol 0.5-1.0, abrasive 16-55, humectant 40-80, cocamidopropyl betaine 4-10, hydroxyethyl cellulose 0.5-1, xanthan gum 0.5-2, chelating agent 0.1-0.6, preservative 0.24-1, and purified water 12.96-20.04.

[0025] This invention provides a toothpaste in which chlorhexidine gluconate inhibits and kills Gram-positive and Gram-negative bacteria in the oral cavity, effectively inhibiting dental plaque and controlling gingivitis and periodontitis. Menthol provides the toothpaste's cooling taste and fresh scent, and also has some antibacterial effect. Cocamidopropyl betaine is used to generate foam. Hydroxyethyl cellulose has a thickening effect. Xanthan gum helps the toothpaste stand stably on a toothbrush and is thinner and easier to disperse in the mouth when sheared. Chelating agents are used to chelate calcium and magnesium ions in water, reducing the interference of hard water on foaming. This toothpaste simultaneously inhibits oral inflammation and kills pathogenic bacteria such as dental plaque, effectively improving oral health.

[0026] As a specific embodiment of the present invention, the Chinese herbal extract includes one or more of dandelion, thistle, and Panax notoginseng.

[0027] In some feasible embodiments, the herbal extract includes dandelion, thistle, and Panax notoginseng. The mass ratio of dandelion, thistle, and Panax notoginseng is 1-2:2-4:1-5. Dandelion contains flavonoids that significantly inhibit and relieve inflammation such as gingivitis, gingivitis, and oral ulcers. Dandelion also inhibits common oral bacteria (such as Staphylococcus aureus and Streptococcus). It also promotes the healing of oral ulcers. Thistle contains flavonoids and sterols that reduce gingival bleeding. Thistle also contains alkaloids and phenolic acids that inhibit oral pathogens. Thistle is used to address the problems of blood on the toothbrush and easy bleeding gums upon touch. Panax notoginseng is warm in nature, sweet and slightly bitter in taste, and enters the liver and stomach meridians. Panax notoginseng contains notoginsenosides that can shorten clotting time, promote platelet aggregation, and simultaneously invigorate blood circulation and remove blood stasis. Panax notoginseng saponins also have significant effects in reducing swelling and pain, as well as improving oral microcirculation.

[0028] In any feasible embodiment, the herbal extract includes dandelion, thistle, and Panax notoginseng. The mass ratio of dandelion, thistle, and Panax notoginseng is 2:2:1.

[0029] As a specific embodiment of the present invention, the preservative includes: methylparaben or / and propylparaben.

[0030] In some feasible embodiments, the preservative includes methylparaben and propylparaben. The mass ratio of methylparaben to propylparaben is 1-2:1-5.

[0031] In one specific embodiment of the present invention, the abrasive includes cobalt salt and / or silica. In some feasible embodiments, the abrasive includes cobalt salt and silica, wherein the mass ratio of cobalt salt to silica is 1-10:15-45. Silica removes stains and plaque from the tooth surface through physical friction. Cobalt salt also has a certain abrasive effect and a thickening effect, which helps toothpaste adhere to the toothbrush.

[0032] In one specific embodiment of the present invention, the moisturizer includes sorbitol and / or glycerin. In some feasible embodiments, the moisturizer includes sorbitol and glycerin, wherein the mass ratio of sorbitol to glycerin is 30-50:10-30. The sorbitol used is 70% liquid sorbitol, used to provide sweetness. The synergistic effect of sorbitol and glycerin also helps maintain the smooth and supple texture of the cream, while increasing its gloss and transparency.

[0033] As a specific embodiment of the present invention, the chelating agent is disodium ethylenediaminetetraacetate.

[0034] As a specific embodiment of the present invention, a toothpaste comprises the following components in parts by weight: chlorhexidine gluconate 0.2, traditional Chinese medicine extract 5, menthol 0.5, coumarin 1, silica 15, sorbitol 70% 50, glycerin 10, cocamidopropyl betaine 4, hydroxyethyl cellulose 0.5, xanthan gum 0.5, disodium EDTA 0.1, methylparaben 0.12, propylparaben 0.12, and purified water 12.96. The traditional Chinese medicine extract includes dandelion, thistle, and Panax notoginseng. The mass ratio of dandelion, thistle, and Panax notoginseng is 2:2:1. The preparation method of this toothpaste includes the following steps:

[0035] S1. Weigh the purified water according to the formula and add it to the vacuum ointment making pot. Heat the temperature to 40-75°C, preferably 65°C, add disodium ethylenediaminetetraacetate, and stir until completely dissolved.

[0036] S2. Add hydroxyethyl cellulose (30,000 viscosity), xanthan gum, sorbitol (70% liquid sorbitol) and glycerin to the solution in sequence, and stir continuously for 20-30 minutes until completely dissolved to obtain a paste;

[0037] S3. Then add silica and cobalt salt to the vacuum paste-making pot; and stir under vacuum for 15-20 minutes to evenly disperse the silica particles and cobalt salt in the paste.

[0038] S4. Cool the paste to 40-45°C, then add cocamidopropyl betaine and menthol in sequence, and stir well.

[0039] S5. Then lower the temperature by 5-10℃, preferably at 36℃, and add chlorhexidine gluconate, traditional Chinese medicine extract and preservative in sequence. Stir for 10-20 minutes first, and then continue stirring under vacuum for 15-40 minutes to obtain the finished product.

[0040] The toothpaste prepared according to the above method can effectively achieve hemostasis and anti-inflammatory effects through the synergistic effect of chlorhexidine gluconate and traditional Chinese medicine extracts. At the same time, it can also effectively decompose the matrix of dental plaque, kill harmful bacteria in dental plaque, and inhibit the growth of dental plaque.

[0041] Example 1

[0042] A toothpaste comprising the following components in parts by weight: chlorhexidine gluconate 0.2, traditional Chinese medicine extract 5, menthol 0.5, coumarin 1, silica 15, sorbitol 70% 50, glycerin 10, cocamidopropyl betaine 4, hydroxyethyl cellulose (30,000 viscosity) 0.5, xanthan gum 0.5, disodium EDTA 0.1, methylparaben 0.12, propylparaben 0.12, and purified water 12.96.

[0043] Example 2

[0044] A toothpaste comprising the following components in parts by weight: 5 parts of traditional Chinese medicine extract, 0.5 parts of menthol, 1 part of codonopsis pilosula, 15 parts of silica, 50 parts of 70% sorbitol, 10 parts of glycerin, 4 parts of cocamidopropyl betaine, 0.5 parts of hydroxyethyl cellulose (30,000 viscosity), 0.5 parts of xanthan gum, 0.1 parts of disodium EDTA, 0.12 parts of methylparaben, 0.12 parts of propylparaben, and 12.96 parts of purified water.

[0045] Example 3

[0046] A toothpaste comprising the following components in parts by weight: chlorhexidine gluconate 0.2, menthol 0.5, coumarin 1, silica 15, sorbitol 70% 50, glycerin 10, cocamidopropyl betaine 4, hydroxyethyl cellulose (30,000 viscosity) 0.5, xanthan gum 0.5, disodium EDTA 0.1, methylparaben 0.12, propylparaben 0.12, and purified water 12.96.

[0047] Example 4

[0048] A toothpaste comprising the following components in parts by weight: menthol 0.5, coumarin 1, silica 15, sorbitol 70% 50, glycerin 10, cocamidopropyl betaine 4, hydroxyethyl cellulose (30,000 viscosity) 0.5, xanthan gum 0.5, disodium EDTA 0.1, methylparaben 0.12, propylparaben 0.12, and purified water 12.96.

[0049] Example 5

[0050] A toothpaste comprising the following components in parts by weight: chlorhexidine gluconate 0.11, traditional Chinese medicine extract 5, menthol 0.5, coumarin 1, silica 15, sorbitol 70% 50, glycerin 10, cocamidopropyl betaine 4, hydroxyethyl cellulose (30,000 viscosity) 0.5, xanthan gum 0.5, disodium EDTA 0.1, methylparaben 0.12, propylparaben 0.12, and purified water 12.96.

[0051] Example 6

[0052] A toothpaste comprising the following components in parts by weight: chlorhexidine gluconate 2.11, traditional Chinese medicine extract 5, menthol 0.5, coumarin 1, silica 15, sorbitol 70% 50, glycerin 10, cocamidopropyl betaine 4, hydroxyethyl cellulose (30,000 viscosity) 0.5, xanthan gum 0.5, disodium EDTA 0.1, methylparaben 0.12, propylparaben 0.12, and purified water 12.96.

[0053] Example 7

[0054] Commercially available toothpaste. Contains the following ingredients: sodium monofluorophosphate, sodium fluoride, sorbitol, water, hydrated silica, polyethylene glycol-8, sodium lauroyl sarcosinate flavoring, sodium monofluorophosphate, cellulose gum, xanthan gum, benzyl alcohol, sodium saccharin, trisodium phosphate, menthol, and sodium propylparaben.

[0055] Performance comparison test

[0056] Dental plaque inhibition ability test

[0057] 1.1 Test samples: Examples 1-7.

[0058] 1.2 Test Method: Hydroxyapatite discs were ultrasonically cleaned, sterilized at high temperature, and then dried for later use. The discs were then immersed in filtered, sterilized mixed saliva from volunteers at 36-37°C with shaking for 0.5-1.5 hours until a thin film of acquired proteins formed on the surface of the discs. The discs with the acquired film were transferred to a culture medium and inoculated with *Streptococcus mutans* and *Porphyromonas gingivalis*, and cultured anaerobicly for 24-72 hours. The culture medium was replaced with fresh medium every 12-24 hours. The culture medium consisted of BHI broth and 1% sucrose. During the culture process, 5%-10% sucrose solution was added 3-8 times daily for 3 minutes each time for pulse exposure. After exposure, the discs were rinsed with physiological saline and returned to the culture medium. The discs were considered ready when a white or pale yellow viscous film formed on the surface, indicating a CFU ≥ 10. 7 A biofilm with an average thickness of not less than 45.8 μm is considered mature. Preparation of toothpaste slurry: Weigh 4 g of the toothpaste shown in Examples 1-7 and dilute it with purified water at a weight ratio of 1:2. Immerse the prepared toothpaste slurry into the hydroxyapatite discs, then use a brushing device to simulate a toothbrush to brush the surface of the hydroxyapatite discs for 3-5 minutes. After brushing, remove the hydroxyapatite discs and rinse the surface with phosphate-buffered saline for 10-30 seconds. Then, count the CFU values ​​on the surface of the hydroxyapatite discs. The values ​​for Examples 1-7 are shown in Table 1 below.

[0059]

[0060] Table 1. Numerical statistics of remaining CFU / tablets in Examples 1-7

[0061] Then, the surface of the hydroxyapatite discs was stained for live / dead cell detection. The values ​​for Examples 1-7 are shown in Table 2 below.

[0062]

[0063] Table 2. Numerical statistics of live / dead cell staining results in Examples 1-7

[0064] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the embodiments of the present invention.

[0065] The toothpaste and its preparation method provided by the present invention have been described in detail above. Specific examples have been used in this specification to illustrate the principle and implementation of the present invention. The above description of the embodiments is only for the purpose of helping to understand the method and core idea of ​​the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation and application scope based on the idea of ​​the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A toothpaste, characterized in that, The product comprises the following components in parts by weight: chlorhexidine gluconate 0.2-2, herbal extract 5-15, menthol 0.5-1.0, abrasive 16-55, humectant 40-80, cocamidopropyl betaine 4-10, hydroxyethyl cellulose 0.5-1, xanthan gum 0.5-2, chelating agent 0.1-0.6, preservative 0.24-1, and purified water 12.96-20.

04.

2. The toothpaste according to claim 1, characterized in that, The herbal extracts include one or more of the following: dandelion, thistle, and Panax notoginseng.

3. The toothpaste according to claim 2, characterized in that, The herbal extract includes dandelion, thistle, and Panax notoginseng; the mass ratio of dandelion, thistle, and Panax notoginseng is 1-2:2-4:1-5.

4. The toothpaste according to claim 3, characterized in that, The preservatives include: methylparaben or / and propylparaben.

5. The toothpaste according to claim 4, characterized in that, The preservatives include methylparaben and propylparaben; the mass ratio of methylparaben to propylparaben is 1-2:1-5.

6. The toothpaste according to claim 5, characterized in that, The friction agent includes: cobalt salt and / or silicon dioxide.

7. The toothpaste according to claim 6, characterized in that, The friction agent comprises: cobalt salt and silicon dioxide; wherein the mass ratio of cobalt salt and silicon dioxide is 1-10:15-45.

8. The toothpaste according to claim 7, characterized in that, The moisturizers include: sorbitol and / or glycerin.

9. The toothpaste according to claim 8, characterized in that, The moisturizer includes sorbitol and glycerin, wherein the mass ratio of sorbitol to glycerin is 30-50:10-30.

10. A method for preparing toothpaste, characterized in that, The preparation of toothpaste according to any one of claims 1-9 comprises the following steps: S1. Weigh the purified water according to the formula and add it to the vacuum ointment making pot. Heat the temperature to 40-75°C, add the chelating agent, and stir until completely dissolved. S2. Add hydroxyethyl cellulose, xanthan gum, sorbitol and glycerin to the solution in sequence, and stir continuously for 20-30 minutes until completely dissolved to obtain a paste; S3. Then add silica and cobalt salt to the vacuum paste-making pot; and stir under vacuum for 15-20 minutes to evenly disperse the silica particles and cobalt salt in the paste. S4. Cool the paste to 40-45°C, then add cocamidopropyl betaine and menthol in sequence, and stir well. S5. Then lower the temperature by 5-10℃, add chlorhexidine gluconate, traditional Chinese medicine extract and preservative in sequence, stir for 10-20 minutes, and then continue stirring for 15-40 minutes under vacuum to obtain the finished product.

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