Natural anti-dandruff and anti-itch shampoo and method of making same

Abstract

The application discloses a natural shampoo for removing dandruff and relieving itching and a preparation method thereof. The shampoo contains, in weight parts, 20-40 parts of cortex dictamni, 20-40 parts of fructus kadsurae, 20-40 parts of tea bran, 20-40 parts of fructus cnidii, 15-25 parts of mulberry bark, 15-25 parts of radix sophorae tonkinensis and 15-25 parts of portulaca oleracea. The tea bran is tea bran powder which is aged for more than 6 months and is crushed to 80-100 meshes. The radix sophorae tonkinensis is radix sophorae tonkinensis which is processed to reduce toxicity. The pH value of the shampoo is 5.0-6.0. The specific combination of seven medicinal materials forms a multi-target dandruff-removing and itching-relieving system, the processing to reduce toxicity of the radix sophorae tonkinensis improves the safety, and the pH value of the product is limited to maintain the acid barrier of the scalp. The natural shampoo for removing dandruff and relieving itching is mainly used for natural plant-derived dandruff-removing and itching-relieving washing and protecting products.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, specifically to a natural shampoo for dandruff and itch relief, and its preparation method. Background Technology

[0002] Dandruff and the accompanying scalp itching are common scalp problems, which are caused by multiple factors including scalp microecological imbalance, abnormal sebum secretion, damage to the stratum corneum barrier, and inflammatory response.

[0003] When preparing anti-dandruff and anti-itch shampoos using traditional Chinese medicine or natural plant compositions, the following problems commonly exist: If herbs with heat-clearing and anti-itch effects, such as raw Sophora tonkinensis root, are used directly in the formula, the toxic alkaloids they contain, such as matrine and cytisine, may cause chronic cumulative irritation through the epidermal barrier during long-term contact with the scalp. Conventional detoxification methods, while reducing toxicity, also result in a significant loss of effective antibacterial components, making it difficult to achieve a balance between safety and effectiveness. Regarding the extraction process, when herbs containing alkaloids, tannins, and saponin precursors, such as Dictamnus dasycarpus root bark, Kochia scoparia fruit, and Cnidium monnieri fruit, are mixed with tea seed cake and boiled together in a single pot of water, different active ingredients are prone to complexation precipitation or thermal degradation in the high-temperature aqueous phase. This leads to a significant reduction in the transfer rate of key active substances such as dictamnus dasycarpus alkaloids and osthol. Furthermore, the relatively high concentration temperature under normal pressure further exacerbates the damage to heat-sensitive components. In terms of finished product performance, natural shampoos containing tea seed oil saponins tend to be slightly alkaline after use. Frequent use can disrupt the natural acidic barrier of the scalp (pH 5.0–6.0), causing an imbalance of resident flora and a decline in the function of the stratum corneum barrier. This leads to compensatory excessive sebum secretion, creating a vicious cycle of tightness after washing, increased oil production, and recurring dandruff. Regarding storage stability, shampoos made from pure plant-based ingredients are rich in polysaccharides, amino acids, and other nutrients easily utilized by microorganisms. Without the addition of chemically synthesized preservatives, they show signs of excessive total bacterial count and rancidity after 7 to 14 days at room temperature. If tea tree oil or rosemary crude extract is added for preservation, the content of effective antibacterial components in the crude extract is low and varies greatly between batches. To achieve the desired antibacterial concentration, the amount added needs to be significantly increased. This introduces a large amount of chlorophyll, tannins, and other impurities, causing the shampoo to darken in color, deteriorate in odor, and may undergo secondary complexation with alkaloids or saponins in the system, compromising the product's appearance uniformity and user experience.

[0004] In conclusion, there is an urgent need for a natural shampoo that can reduce toxicity and enhance efficacy at the formulation level, retain activity and avoid adverse interactions between ingredients at the process level, and simultaneously address dandruff and itching while regulating the scalp microenvironment at the functional level, while also possessing excellent stability and safety. Summary of the Invention

[0005] One object of the present invention is to address at least the aforementioned deficiencies and to provide at least the advantages that will be described later.

[0006] This invention provides a natural shampoo for dandruff and itching relief, comprising the following ingredients in parts by weight: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of tea seed cake, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, 15-25 parts of Sophora tonkinensis root, and 15-25 parts of Portulaca oleracea. The tea seed cake is aged for more than 6 months and pulverized to 80-100 mesh; the Sophora tonkinensis root is processed to reduce toxicity; and the pH value of the natural shampoo for dandruff and itching relief is 5.0-6.0.

[0007] In the above formula, Dictamnus dasycarpus root bark contains alkaloids such as dictamnus alkaloid, which have the effects of clearing heat and drying dampness, dispelling wind and relieving itching; Kochia scoparia fruit contains triterpenoid saponins, which can inhibit various skin fungi; Cnidium monnieri fruit contains coumarin components such as osthol, which have anti-inflammatory and antipruritic activities; Morus alba root bark contains flavonoid components, which can regulate sebum secretion; Portulaca oleracea contains organic acids and flavonoids, which have soothing and anti-inflammatory effects; Tea bran contains saponins, which provide natural cleansing and foaming functions; Sophora tonkinensis root contains alkaloids such as matrine, which have strong antibacterial and antipruritic effects. By combining Dictamnus dasycarpus root bark, Kochia scoparia fruit, Cnidium monnieri fruit, Morus alba root bark, Portulaca oleracea with tea bran and Sophora tonkinensis root in a specific ratio, a multi-target action system that clears heat and dries dampness, dispels wind and relieves itching, astringes and controls oil and repairs the skin barrier is formed. The various medicinal materials have synergistic effects, and Sophora tonkinensis root is safely incorporated into the formula after being processed to reduce toxicity. This solves the problems of single efficacy and insufficient safety of existing formulas, and achieves the effect of removing dandruff and relieving itching while maintaining the scalp's microecological balance.

[0008] Preferably, the natural shampoo for dandruff and itch relief further includes 0.5% to 2% of bamboo leaf extract or 0.1% to 1% of rosemary extract by weight of the total raw materials; the bamboo leaf extract contains no less than 30% total flavonoids; the rosemary extract contains no less than 20% caryopsisic acid and no less than 3% rosmarinic acid; the bamboo leaf extract is obtained by: pulverizing bamboo leaves to 40-80 mesh; refluxing with 8-12 times the amount of 50%-70% ethanol 2-3 times, 1-2 hours each time, combining the extracts; and recovering the ethanol under reduced pressure until ethanol residue is obtained. If the residue is less than 0.5%, add water to disperse the drug solution to a concentration of 0.1~0.2g crude drug / mL; perform column chromatography with AB-8 or D101 macroporous adsorption resin; recover ethanol under reduced pressure and dry under vacuum; the rosemary extract is obtained by the following method: take dried rosemary leaves, crush them to 20~40 mesh, and extract them with supercritical CO2; the supercritical CO2 extraction pressure is 25~30MPa, the temperature is 40~45℃, the extraction time is 2~3 hours, the CO2 flow rate is 15~25L / kg raw material per hour, the separation pressure is 6~8MPa, and the temperature is 35~40℃.

[0009] The above solution uses high-purity natural extracts as preservatives, which can effectively inhibit microbial growth with a low addition amount, and avoid the interference of impurities in crude extracts on the color and stability of the product.

[0010] Preferably, the detoxification treatment of Sophora tonkinensis described in this invention is steaming with licorice juice or honey-processing, specifically including: the steaming process with licorice juice is as follows: take Sophora tonkinensis slices, add 10% to 20% of the weight of the Sophora tonkinensis slices of licorice decoction and mix well, seal and moisten until the juice is absorbed, then steam at 100 to 110°C for 2 to 4 hours, and then dry at a low temperature below 60°C until the moisture content is less than 9%; the honey-processing process is as follows: take Sophora tonkinensis slices, add 15% to 25% of the weight of the Sophora tonkinensis slices of refined honey, mix well and seal and moisten for 2 to 4 hours, place in a stir-frying container and stir-fry continuously at 120 to 140°C until the surface of the slices turns dark yellow and is not sticky to the touch, and after cooling, sift out the debris.

[0011] The above-mentioned scheme, by limiting the processing of Sophora tonkinensis to steaming with licorice juice or honey-processing to reduce toxicity, precisely controls the amount of licorice juice, steaming temperature and time or honey ratio, stir-frying temperature and endpoint, selectively degrading or transforming toxic alkaloids while retaining the quinolone active ingredients with antifungal activity. Furthermore, trace residues of processing excipients can exert anti-inflammatory, soothing, and film-forming protective effects, solving the dilemma of simultaneously achieving toxicity reduction and efficacy preservation in Sophora tonkinensis. This achieves the effect of safely using a potent antipruritic herb while improving the overall mildness of the formula. During the steaming process with licorice juice, glycyrrhizic acid complexes with toxic alkaloids or promotes their thermal degradation. Simultaneously, steaming loosens the cell walls, facilitating the dissolution of active ingredients during subsequent alcohol extraction. During the honey-processing process, the reducing sugars in the honey undergo Maillard reactions with the amino groups of toxic alkaloids, converting them into low-toxicity products. The protective surface layer formed during honey-processing can also slow down the oxidation of active ingredients during storage. The toxicity of Sophora tonkinensis is reduced after processing, but its inhibitory activity against common scalp bacteria such as Malassezia is retained. Its ethanol extraction can selectively dissolve fat-soluble active ingredients, avoiding the co-dissolution of toxic components during the water extraction process.

[0012] This invention also provides a method for preparing the aforementioned natural dandruff-reducing and anti-itch shampoo, comprising the following steps: The raw materials were obtained and mixed according to the following weight proportions: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, and 15-25 parts of Portulaca oleracea fruit. The mixture was decocted 2-3 times with water. The amount of water added for the first time was 8-12 times the total weight of the medicinal materials, and the amount of water added for the second and subsequent times was 6-10 times the total weight of the medicinal materials. Each decoction was 1-2 hours. The decoctions were combined and concentrated under reduced pressure at 60-70℃ and -0.08--0.09 MPa to a water-extracted thick paste with a relative density of 1.05-1.20.

[0013] Take 15-25 parts of Sophora tonkinensis root, process it to reduce toxicity, then pulverize it to 20-40 mesh, add 6-10 times the amount of 60%-75% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, and recover the ethanol under reduced pressure at 55-65℃ and -0.08--0.09MPa, and concentrate it until the ethanol residue is less than 0.5%, to obtain the ethanol extract thick paste.

[0014] Combine the water-extracted thickener and the alcohol-extracted thickener at 40–50°C and stir at 60–100 rpm for 10–20 minutes until homogeneous to obtain a mixed thickener.

[0015] Take 20-40 parts of tea seed cake and grind it to 80-100 mesh. Add it to the mixed paste in 2-3 portions. After each addition of the mixed paste, stir at 40-60 rpm for 5-10 minutes. Then add the shampoo excipients and stir at 40-60 rpm for 15-30 minutes. Adjust the pH value to 5.0-6.0 to obtain the natural shampoo for removing dandruff and relieving itching.

[0016] Specifically, the shampoo excipients are glycerin, hydroxyethyl cellulose, and cocoylpropyl betaine. The above process effectively avoids problems such as alkaloid-tannin complexation and precipitation, and saponin pyrolysis that occur in traditional co-decoction processes, thus improving the transfer rate of active ingredients.

[0017] Preferably, when the natural preservative is bamboo leaf extract, the preparation method includes the following steps: Dictamnus dasycarpus root bark, Kochia scoparia fruit, Cnidium monnieri fruit, Morus alba root bark, and Portulaca oleracea fruit were obtained in the above-mentioned weight proportions, and were decocted in water and concentrated under reduced pressure to obtain a water-extracted thick paste; Sophora tonkinensis root was processed to reduce toxicity and then extracted with alcohol to obtain an alcohol-extracted thick paste; the water-extracted thick paste and the alcohol-extracted thick paste were combined and stirred to obtain a mixed thick paste.

[0018] Take 20-40 parts of tea seed cake and grind it to 80-100 mesh to obtain tea seed cake powder; take 0.5%-2% of the total weight of bamboo leaf extract and 10%-30% of the total weight of the tea seed cake powder and stir and mix them at 30-50 rpm for 5-15 minutes until the powder color is uniform to obtain tea seed cake premixed powder.

[0019] Add the premixed tea seed powder and the remaining tea seed powder to the mixed paste in 2-3 batches. After each addition, stir at a speed of 40-60 rpm for 5-10 minutes. Then add the humectant, thickener, and surfactant and stir at a speed of 40-60 rpm for 15-30 minutes. Adjust the pH value to 5.0-6.0 to obtain the natural shampoo for dandruff and itch relief of the present invention.

[0020] Preferably, when the natural preservative is rosemary extract, the preparation method includes the following steps: The raw materials were obtained and mixed according to the following weight proportions: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, and 15-25 parts of Portulaca oleracea fruit. The mixture was decocted 2-3 times with water. The amount of water added for the first time was 8-12 times the total weight of the medicinal materials, and the amount of water added for the second and subsequent times was 6-10 times the total weight of the medicinal materials. Each decoction was 1-2 hours. The decoctions were combined and concentrated under reduced pressure at 60-70℃ and -0.08--0.09 MPa to a water-extracted thick paste with a relative density of 1.05-1.20.

[0021] Take 15-25 parts of Sophora tonkinensis root, process it to reduce its toxicity, then pulverize it to 20-40 mesh. Add 6-10 times the amount of 60%-75% ethanol, and reflux extract it 2-3 times, 1-2 hours each time. Combine the extracts, and recover the ethanol under reduced pressure at 55-65℃ and -0.08--0.09MPa. Concentrate the ethanol until the residual ethanol content is less than 0.5% to obtain the ethanol extract thick paste.

[0022] Combine the water-extracted thickener and the alcohol-extracted thickener at 40-50°C and stir at 60-100 rpm for 10-20 minutes until homogeneous to obtain a mixed thickener.

[0023] Take 20-40 parts of tea seed cake and grind it to 80-100 mesh to obtain tea seed cake powder; first, add 0.1%-1% of the total weight of the raw material rosemary extract to 2-5 times its own weight of 75%-95% ethanol, and stir at 25-35℃ until completely dissolved to obtain a rosemary alcohol solution; then, under stirring, uniformly spray the rosemary alcohol solution onto 10%-30% of the total weight of the tea seed cake powder, and then dry under reduced pressure at 30-40℃ and -0.08--0.09MPa for 30-60 minutes to remove the ethanol, and obtain the second premixed powder.

[0024] The second premixed powder and the remaining tea seed powder are added to the mixed paste in 2 to 3 portions. After each addition, the mixture is stirred at a speed of 40 to 60 rpm for 5 to 10 minutes. Then, the humectant, thickener, and surfactant are added and stirred at a speed of 40 to 60 rpm for 15 to 30 minutes. The pH value is adjusted to 5.0 to 6.0 to obtain the natural shampoo for dandruff and itch relief of the present invention.

[0025] Preferably, when using bamboo leaf extract, the preparation of the tea seed cake premix powder further includes pretreatment of the bamboo leaf extract, specifically including: Bamboo leaf extract was co-ground with a natural polysaccharide carrier at a ratio of 1:0.2 to 0.5 by weight. The natural polysaccharide carrier was any one of maltodextrin, gum arabic, or hydroxypropyl-β-cyclodextrin. The grinding speed was 60 to 100 rpm and the grinding time was 10 to 20 minutes to obtain a grinding mixture.

[0026] Add 10%–20% of the total weight of the ground mixture and 50%–70% of the volume of an ethanol solution to the mixture. Gradually heat the mixture to 45–55°C while stirring at 40–60 rpm, and continue stirring for 20–30 minutes to form a paste-like dispersion.

[0027] Take 20-40 parts of tea bran and grind it to 80-100 mesh to obtain tea bran powder; divide the tea bran powder into two parts in a weight ratio of 1-3:7-9, with the first tea bran powder accounting for 10%-30% of the total weight of the tea bran powder; evenly coat the surface of the first tea bran powder with the paste dispersion, place it in a vacuum drying oven, and dry it under reduced pressure at 40-50℃ and -0.08--0.09MPa for 60-90 minutes, while turning the material every 15 minutes, until the moisture content is less than 5%, cool to room temperature, and pass through a 60-mesh sieve to obtain the bamboo leaf extract-tea bran complex.

[0028] The bamboo leaf extract-tea bran complex and the remaining tea bran powder are added to the mixed paste in 2-3 portions. After each addition, the mixture is stirred at 40-60 rpm for 5-10 minutes. Then, the humectant, thickener and surfactant are added and stirred at 40-60 rpm for 15-30 minutes. The pH value is adjusted to 5.0-6.0 to obtain the natural shampoo for dandruff and itch relief of the present invention.

[0029] Preferably, after uniformly coating the paste dispersion onto the surface of the first tea seed cake powder and before placing it in a vacuum drying oven, the following steps are also included: The first tea seed cake powder coated with the paste dispersion is transferred to a sealed container and left to stand at 20-30°C for 30-60 minutes, allowing the ethanol-water system in the paste dispersion to naturally penetrate into the tea seed cake powder particles through capillary action. During the standing period, the container is kept sealed, and the relative humidity is controlled at 65%-75%. Then, the tea seed cake powder is spread evenly on a tray and placed at 30-35°C and normal pressure for 15-30 minutes, allowing the excess solvent on the surface to evaporate until the material is in a state where it does not clump when squeezed and can be easily dispersed by light touch. Finally, it is placed in a vacuum drying oven for subsequent reduced pressure drying.

[0030] Preferably, before uniformly coating the paste dispersion onto the surface of the first tea seed cake powder, the method further includes pre-treating the first tea seed cake powder: placing the first tea seed cake powder in a mixer equipped with a spray device, and uniformly spraying 3% to 8% of its weight of deionized water onto the surface of the first tea seed cake powder while stirring at 40 to 60 rpm, with the spray particle size controlled at 10 to 30 μm, and continuing to stir for 3 to 8 minutes to make the surface of the first tea seed cake powder particles slightly moist and form loose micro-agglomerates; then, the micro-agglomerates are ventilated and dried for 10 to 15 minutes at 30 to 35°C and 50% to 60% relative humidity until the moisture content of the micro-agglomerates returns to the level before spraying and maintains the agglomerated morphology, to obtain the pre-granulated first tea seed cake powder; and then uniformly coating the surface of the pre-granulated first tea seed cake powder with the paste dispersion.

[0031] Preferably, after obtaining the pre-granulated first tea seed cake powder and before uniformly coating the paste dispersion onto the surface of the pre-granulated first tea seed cake powder, the method further includes the following steps: placing the pre-granulated first tea seed cake powder and 0.2% to 0.5% of its weight of cold-pressed tea oil in a mixer and mixing for 5 to 10 minutes at 15 to 25°C and 20 to 30 rpm, so that the tea oil forms a hydrophobic oil film on the surface of the micro-aggregates, thereby obtaining surface-hydrophobic micro-aggregates; then uniformly coating the paste dispersion onto the surface of the surface-hydrophobic micro-aggregates.

[0032] The synergistic effect of the above-mentioned optimized process steps significantly improves the uniformity of bamboo leaf extract loading and curing stability on the tea bran carrier, thereby ensuring the uniform distribution of preservative components in the final paste and avoiding excessively high local concentrations or preservative blind spots.

[0033] The present invention has at least the following beneficial effects: Firstly, this invention treats *Sophora tonkinensis* root by steaming it with licorice juice or processing it with honey, followed by separate extraction with ethanol. This selectively degrades highly toxic components such as cytisine during the processing stage, while preserving and efficiently dissolving antibacterial matrine and oxymatrine. Simultaneously, it avoids the drawback of co-dissolving toxic and active ingredients during water extraction. Shampoo containing *Sophora tonkinensis* root, treated in this way, maintains its dandruff-reducing and anti-itch effects while significantly reducing scalp irritation, effectively alleviating the technical contradiction of poor safety of raw *Sophora tonkinensis* root and insufficient potency resulting from conventional detoxification methods.

[0034] Secondly, this invention involves decocting and concentrating five medicinal herbs—Dictamnus dasycarpus root bark, Kochia scoparia fruit, Cnidium monnieri fruit, Morus alba root bark, and Portulaca oleracea—using water as a solvent, while extracting and concentrating Sophora tonkinensis root separately with ethanol. The two thick extracts are then combined under mild conditions and mixed with tea seed powder, with low-temperature, reduced-pressure concentration used throughout the process. This "separate extraction and combined mixing" process effectively avoids problems such as the complexation and precipitation of alkaloids and tannins, and the pyrolysis of saponins, which occur in traditional one-pot decoction methods. This significantly improves the transfer rate of key active ingredients such as dictamnus alkaloids and osthol, while reducing the destruction of heat-sensitive flavonoids and terpenoids.

[0035] Furthermore, this invention addresses the issue of segregation that easily occurs when bamboo leaf flavonoid powder and tea bran powder are directly dry-mixed. It employs a method of dry powder premixing or co-drying via alcohol solution spraying, utilizing the rough surface and fibrous pores of the tea bran powder to adsorb or in-situ embed the extract. To address the incompatibility between the fat-soluble paste and hydrophilic powder of rosemary, an ethanol-dissolved powder is sprayed onto the tea bran powder followed by vacuum drying, ensuring the active ingredients are uniformly solidified within the tea bran fibers. When the resulting premixed powder is added to the thick paste in portions with the tea bran powder, it is gradually released as the tea bran is moistened, achieving a uniform distribution of preservative components in the shampoo and avoiding irritation or preservative blind spots caused by excessively high local concentrations. In particular, pre-granulation and tea oil hydrophobication treatment further optimize the carrying capacity of the tea bran powder for the extract, improving the storage stability and dispersibility of the complex.

[0036] Furthermore, this invention selects high-purity bamboo leaf extract (total flavonoids ≥30%) or rosemary extract (sarsaparilla acid ≥20%, rosmarinic acid ≥3%) and adds them to the formula in precise amounts. This effectively inhibits the growth of microorganisms in the shampoo even with low addition amounts. At the same time, it limits the product's pH value to 5.0-6.0, the relative density of the water-extracted thickener, and the residual ethanol content of the alcohol-extracted thickener. The synergistic effect of these parameters enables the product to achieve acceptable shelf-life stability without the addition of chemically synthesized preservatives, and avoids the problems of color darkening, odor deterioration, and secondary complexation between components caused by the introduction of impurities from crude extracts. Detailed Implementation

[0037] The present invention will be further described in detail below with reference to embodiments, so that those skilled in the art can implement it based on the description.

[0038] Example 1 A natural shampoo for dandruff and itching is prepared through the following steps: Step 1: Weigh out 30 parts of Dictamnus dasycarpus root bark, 30 parts of Kochia scoparia fruit, 30 parts of Cnidium monnieri fruit, 20 parts of Morus alba root bark, and 20 parts of Portulaca oleracea fruit according to their weight proportions. Mix them together and decoct twice with water. The first time, add water at 10 times the total weight of the herbs, and the second time, add water at 8 times the total weight of the herbs. Each decoction should last for 1.5 hours. Combine the decoctions, filter, and concentrate under reduced pressure at 65℃ and -0.085MPa to a relative density of 1.10. Measure the relative density at 60℃ to obtain a water-extracted thick paste.

[0039] Step 2: First, steam 20 parts of Sophora tonkinensis root with licorice decoction: Take Sophora tonkinensis root slices, add 15% of the weight of the slices of licorice decoction and mix well. Seal and moisten until the juice is absorbed. Steam at 105℃ for 3 hours, and dry at a low temperature below 60℃ until the moisture content is less than 9%. Crush the processed Sophora tonkinensis root into 30 mesh, add 8 times the amount of 68% ethanol, and reflux extract twice, 1.5 hours each time. Combine the extracts, and recover the ethanol under reduced pressure at 60℃ and -0.085MPa and concentrate until the ethanol residue is less than 0.5% to obtain an alcohol-extracted thick paste.

[0040] Step 3: Combine the water-extracted thick paste obtained in Step 1 and the alcohol-extracted thick paste obtained in Step 2 at 45°C and stir at 80 rpm for 15 minutes until homogeneous to obtain a mixed thick paste.

[0041] Step 4: Take 30 parts of tea seed cake powder that has been aged for 8 months and ground to 100 mesh, and add it to the mixed paste obtained in Step 3 in 3 portions. Stir at 50 rpm for 8 minutes after each addition.

[0042] Step 5: Add 8 parts glycerin, 0.6 parts hydroxyethyl cellulose, and 5 parts cocoyl propyl betaine to the material obtained in Step 4. Stir at 50 rpm for 20 minutes. Adjust the pH value to 5.5 with citric acid to obtain the natural shampoos for dandruff and itch relief of the present invention.

[0043] Example 2 The preparation method of the natural shampoo for dandruff and itch relief is based on Example 1, except that steps three to six are replaced with: Step 3: Combine and stir the water-extracted thickener and the alcohol-extracted thickener according to the method in Example 1 to obtain a mixed thickener.

[0044] Step 4: Take 30 portions of tea seed cake powder that has been aged for 8 months and pulverized to 100 mesh, and another 1% (by weight of the total raw material) of bamboo leaf extract. The total flavonoid content of this bamboo leaf extract is 35%, and its preparation method is as follows: Pulverize bamboo leaves to 60 mesh, extract twice with 10 times the amount of 60% ethanol under reflux, 1.5 hours each time, combine the extracts, recover the ethanol under reduced pressure until the residue is less than 0.5%, add water to disperse to 0.15 g crude drug / mL, and perform column chromatography on AB-8 macroporous adsorption resin. First, wash with 4 times the resin volume of water to remove impurities, then elute with 5 times the resin volume of 60% ethanol. Collect the eluent, recover the ethanol under reduced pressure, and vacuum dry to obtain the final product. Mix this bamboo leaf extract with 20% (by weight of the total tea seed cake powder), stir at 40 rpm for 10 minutes until the color is uniform, and obtain tea seed cake premix powder.

[0045] Step 5: Add the tea seed premix powder and the remaining tea seed powder to the mixed paste in 3 batches, stirring at 50 rpm for 8 minutes after each addition.

[0046] Step 6: Add 8 parts glycerin, 0.6 parts hydroxyethyl cellulose, and 5 parts cocoyl propyl betaine. Stir at 50 rpm for 20 minutes. Adjust the pH to 5.5 with citric acid to obtain the natural shampoos for dandruff and itch relief of the present invention.

[0047] Example 3 The preparation method of the natural shampoo for dandruff and itch relief is based on Example 1, except that steps three to six are replaced with: Step 3: Combine the water-extracted thick paste obtained in Step 1 and the alcohol-extracted thick paste obtained in Step 2 at 45°C and stir at 80 rpm for 15 minutes until homogeneous to obtain a mixed thick paste.

[0048] Step 4: Take 30 portions of tea seed cake powder that has been aged for 8 months and pulverized to 100 mesh. Take 0.5% of the total weight of the raw material, rosemary extract, which contains 25% carrageenan and 4% rosmarinic acid. The preparation method is as follows: Pulverize dried rosemary leaves to 30 mesh, and extract using supercritical CO2 at an extraction pressure of 28 MPa, a temperature of 42°C, an extraction time of 2.5 hours, a CO2 flow rate of 20 L / kg raw material per hour, and a separation pressure of 7 MPa and a temperature of 38°C. Add the rosemary extract to ethanol with a volume fraction of 85% and three times its own weight, and stir at 30°C until completely dissolved to obtain a rosmarinic alcohol solution. While stirring, evenly spray the rosmarinic alcohol solution onto 20% of the total weight of the tea seed cake powder, and dry under reduced pressure at 35°C and -0.085 MPa for 45 minutes to remove the ethanol, obtaining the second premixed powder.

[0049] Step 5: Add the second premixed powder and the remaining tea seed powder to the mixed paste in 3 batches, stirring at 50 rpm for 8 minutes after each addition.

[0050] Step 6: Add 8 parts glycerin, 0.6 parts hydroxyethyl cellulose, and 5 parts cocoyl propyl betaine. Stir at 50 rpm for 20 minutes. Adjust the pH to 5.5 with citric acid to obtain the natural shampoos for dandruff and itch relief of the present invention.

[0051] Example 4 A natural shampoo for dandruff and itching is prepared through the following steps: Step 1: Obtain the water-based thickening paste as in Example 1.

[0052] Step 2: Obtain the alcohol-extracted thick paste as in Example 1.

[0053] Step 3: Obtain the mixed thick paste as in Example 1.

[0054] Step 4: Take 1% (by weight) of bamboo leaf extract (prepared in the same manner as in Example 2) and maltodextrin at a weight ratio of 1:0.3 and grind them together at 80 rpm for 15 minutes to obtain a grinding mixture. Add 15% (by weight) of 60% (by volume) ethanol solution to the obtained grinding mixture, and gradually heat to 50°C while stirring at 50 rpm. Continue stirring at this temperature for 25 minutes to form a paste-like dispersion.

[0055] Step 5: Take 30 parts of tea seed cake powder pulverized to 100 mesh and divide it into two parts by weight ratio of 2:8. The first part of the tea seed cake powder should be 20% of the total weight of the tea seed cake powder. Evenly coat the paste dispersion obtained in Step 4 onto the surface of the first tea seed cake powder, transfer it to a sealed container, and let it stand for 45 minutes at 25°C and 70% relative humidity, allowing the ethanol-water system in the paste dispersion to naturally penetrate into the tea seed cake powder particles through capillary action. Then, spread the tea seed cake powder evenly on a tray and place it at 33°C and normal pressure for 20 minutes, until the material is in a state where it does not clump when squeezed and can be easily dispersed by light touch. Then, place it in a vacuum drying oven and dry it under reduced pressure at 45°C and -0.085MPa for 75 minutes, turning the material every 15 minutes, until the moisture content is less than 5%. Cool it to room temperature and pass it through a 60-mesh sieve to obtain the bamboo leaf extract-tea seed cake complex.

[0056] Step 6: Add the complex obtained in Step 5 and the remaining tea seed powder to the mixed paste obtained in Step 3 in 3 batches, stirring at 50 rpm for 8 minutes after each addition.

[0057] Step 7: Add 8 parts glycerin, 0.6 parts hydroxyethyl cellulose, and 5 parts cocoyl propyl betaine to the material obtained in Step 6. Stir at 50 rpm for 20 minutes. Adjust the pH value to 5.5 with citric acid to obtain the natural shampoos for dandruff and itch relief of the present invention.

[0058] Example 5 The preparation method of the natural shampoo for dandruff and itching relief differs from Example 4 in that, before uniformly coating the paste dispersion, the first tea seed cake powder is pretreated. Specifically, the first tea seed cake powder is placed in a mixer equipped with a spray device, and while stirring at 50 rpm, 5% by weight of deionized water is uniformly sprayed onto the surface of the first tea seed cake powder. The spray particle size is controlled at 20 μm. Stirring continues for 5 minutes to slightly moisten the particle surface and form loose micro-aggregates. Then, the micro-aggregates are ventilated and dried at 33°C and 55% relative humidity for 12 minutes until the moisture content of the micro-aggregates returns to the level before spraying and maintains the agglomerated morphology, resulting in pre-granulated first tea seed cake powder. The paste dispersion is then uniformly coated onto the surface of the pre-granulated first tea seed cake powder, and the remaining steps are the same as in Example 4.

[0059] Example 6 The preparation method of the natural shampoo for dandruff and itch relief differs from that of Example 5 in that, after obtaining the pre-granulated first tea seed cake powder and before coating the paste dispersion, the following steps are included: placing the pre-granulated first tea seed cake powder and 0.3% of its weight of cold-pressed tea oil in a mixer and mixing for 8 minutes at 20°C and 25 rpm, so that the tea oil forms a hydrophobic oil film on the surface of the micro-aggregates, thus obtaining surface-hydrophobic micro-aggregates; then uniformly coating the paste dispersion onto the surface of the surface-hydrophobic micro-aggregates, with the remaining steps being the same as in Example 5.

[0060] I. Experiment on the detoxification effect of processing Sophora tonkinensis 1. Test Protocol Take the same batch of Sophora tonkinensis root slices and process them in the following ways: Sophora tonkinensis root slices are directly crushed without any processing and are classified as the raw product group; Sophora tonkinensis root slices are decocted twice with water, one hour each time, and the decoctions are combined, concentrated and dried and classified as the detoxification group; Sophora tonkinensis root slices are processed according to the licorice juice steaming method described in the instructions, with the amount of licorice juice being 15% of the weight of the slices, the steaming temperature being 105℃, and the steaming time being 3 hours and classified as the licorice juice steaming group; Sophora tonkinensis root slices are processed according to the honey-frying method described in the instructions, with the amount of refined honey being 20% ​​of the weight of the slices, the frying temperature being 130℃, and the surface being deep yellow and not sticky when squeezed by hand and classified as the honey-frying group.

[0061] After each sample was pulverized, it was extracted twice with 68% ethanol under reflux for 1.5 hours each time. The extracts were combined, and the contents of matrine, oxymatrine, and cytisine were determined. Separately, solutions of each group's ethanol extracts were prepared with the same concentration of crude drug and subjected to skin irritation tests on rabbits.

[0062] 2. Testing Methods The content of active ingredients was determined by high performance liquid chromatography (HPLC). The chromatographic conditions were: C18 column, mobile phase of acetonitrile-0.1% phosphoric acid aqueous solution gradient elution, and detection wavelength of 220 nm. The contents of cytisine, matrine, and oxymatrine were calculated using the external standard method, with the content of the raw product group representing 100%, and the contents of the other groups expressed as relative percentages.

[0063] The skin irritation test was conducted according to the skin irritation / corrosion test method in the "Cosmetic Safety Technical Specifications". The test substance was applied to the hairless area on the back of the rabbit, and the erythema and edema were observed at 24 hours, 48 ​​hours, and 72 hours. The results were scored according to the scoring criteria.

[0064] 3. The experimental data are shown in Table 1.

[0065] Table 1: Effects of different processing methods on the active ingredients and irritant properties of Sophora tonkinensis. 4. Data Analysis and Conclusions Table 1 shows that the raw product group had the highest cytisine content, with a skin irritation score of 3.8, indicating moderate irritation. Direct use in shampoo products poses a significant safety hazard. While the boiling detoxification group reduced cytisine content to 28.5% and the skin irritation score to 1.2, the relative contents of matrine and oxymatrine were only 42.3% and 38.6%, respectively, indicating a significant loss of active ingredients. In contrast, the relative contents of cytisine in the licorice juice steaming group and the honey-processing group decreased to 35.7% and 31.2%, respectively, and the skin irritation scores were reduced to mild irritation levels. Meanwhile, the relative contents of matrine and oxymatrine remained above 78% and 79%, respectively, achieving selective degradation of toxic components and high retention of active ingredients.

[0066] The above experiments prove that the detoxification method of Sophora tonkinensis described in this invention effectively solves the problem that detoxification and efficacy preservation of Sophora tonkinensis are mutually exclusive.

[0067] II. Comparative Experiment of Separate Extraction and Mixing Process and One-Pot Process 1. Test Protocol According to the method described in Example 1, the white peony bark, Kochia scoparia fruit, Cnidium monnieri fruit, mulberry bark, and purslane were extracted into a water-based thick paste, and the processed Sophora tonkinensis root was extracted into an alcohol-based thick paste. The two were then combined as a separate extraction and mixing process group.

[0068] Mix Dictamnus dasycarpus root bark, Kochia scoparia fruit, Cnidium monnieri fruit, Morus alba root bark, Portulaca oleracea and Sophora tonkinensis root, add water and decoct twice, 1.5 hours each time, combine the decoctions, concentrate under normal pressure to a consistency similar to that of the fractional extracts, and use as a one-pot decoction.

[0069] Two groups of samples were taken and the contents of dictamnusin, osthol, and matrine were determined. The transfer rate was calculated using the content of each herb extracted individually as the theoretical value.

[0070] 2. Testing Methods The contents of dictamnusin, osthol, and matrine were determined by high-performance liquid chromatography (HPLC). The detection wavelengths were 236 nm for dictamnusin, 322 nm for osthol, and 220 nm for matrine.

[0071] Transfer rate = Actual measured content / Theoretical content × 100%.

[0072] 3. The test results are shown in Table 2.

[0073] Table 2: Comparison of Active Ingredient Transfer Rate between Separation and Mixing Process and One-Pot Process 4. Data Analysis and Conclusions As shown in Table 2, in the one-pot method, due to the complexation and precipitation of alkaloids and tannins in the medicinal materials in the high-temperature aqueous phase, the transfer rates of dictamnus alkaloids, osthol, and matrine were only 35.6%, 41.3%, and 40.8%, respectively. In contrast, the separate extraction and mixing process of this invention, by extracting easily interacting medicinal materials separately, increased the transfer rates of the three active ingredients to 82.4%, 85.7%, and 79.1%, respectively, approximately double that of the one-pot method. Furthermore, the use of low-temperature vacuum concentration effectively protected the heat-sensitive components.

[0074] The above experiments demonstrate that the fractionation and mixing process of this invention can significantly improve the utilization rate of key active ingredients in the formulation.

[0075] III. Anti-dandruff and anti-itch efficacy test 1. Test Protocol Sixty volunteers with moderate to severe dandruff and itching were randomly divided into three groups of 20 each. Group 1 used the shampoo from Example 1, Group 2 used the shampoo from Example 2, and Group 3 used the comparative shampoo. The comparative shampoo was a commercially available chemical anti-dandruff shampoo containing zinc pyrithione. Participants in each group washed their hair every other day for four weeks. No other anti-dandruff or hair care products were allowed during the trial.

[0076] 2. Testing Methods The dandruff removal effect was assessed using the scalp keratin exfoliation index scoring method. A professional dermatologist scored the subject's scalp before the trial and 4 weeks after the trial. The score ranged from 0 to 5, with a higher score indicating more severe dandruff.

[0077] The itch relief effect was assessed using a visual analog scale (VAS) method. Subjects self-assessed the degree of scalp itching before the trial and 4 weeks after the trial, with scores ranging from 0 to 10. Higher scores indicated more severe itching.

[0078] 3. The experimental data are shown in Table 3.

[0079] Table 3: Changes in dandruff and itching scores before and after use in each group 4. Data Analysis and Conclusions As shown in Table 3, after 4 weeks of continuous use, the dandruff improvement rates in Example 1 and Example 2 were 64.3% and 69.8%, respectively, and the itching improvement rates were 71.2% and 76.0%, respectively, both reaching or exceeding the levels of chemical anti-dandruff shampoos. Example 2, due to the addition of bamboo leaf extract, was slightly better than Example 1 in terms of anti-inflammatory and soothing effects, with an itching improvement rate approximately 4.8 percentage points higher.

[0080] The above tests prove that the shampoo of the present invention has the same dandruff-removing and anti-itch effect as commercially available chemical anti-dandruff products, and the natural ingredients are gentle on the scalp and have no chemical irritation.

[0081] IV. Corrosion Resistance Stability Test 1. Test Protocol Shampoos containing bamboo leaf extract (Example 2), rosemary extract (Example 3), and no preservatives (Example 1) were prepared. A comparative example was prepared by adding 2% crude rosemary extract to the shampoo of Example 1 as a preservative. All samples were sealed and placed at room temperature, 45°C, and -10°C. Samples were taken at 0, 7, 14, 21, and 30 days to detect total bacterial count and mold / yeast count. Changes in appearance, color, and odor were also observed.

[0082] 2. Testing Methods Microbiological testing was conducted according to the microbiological testing methods outlined in the "Cosmetic Safety Technical Specifications". The total bacterial count limit was set at no more than 1000 CFU / g, and the total mold and yeast count limit was set at no more than 100 CFU / g. Appearance and odor were independently observed and scored by three trained evaluators.

[0083] 3. The experimental data are shown in Table 4.

[0084] Table 4: Changes in total bacterial count in each group under accelerated conditions at 45℃ 4. Data Analysis and Conclusions As shown in Table 4, Example 1, without added preservatives, exceeded the standard for total bacterial count on day 14 under accelerated conditions at 45°C, indicating that pure plant-based shampoos cannot meet shelf-life requirements without effective preservative measures. While the comparative example using 2% rosemary crude extract could control the total bacterial count within acceptable limits, its appearance was darker and its odor stronger, indicating that impurities in the crude extract had a significant adverse effect on the product's sensory characteristics. Examples 2 and 3 maintained total bacterial counts below 100 CFU / g during the 30-day test period, with no abnormal changes in appearance or odor.

[0085] The above experiments confirm that the high-purity bamboo leaf extract and rosemary extract selected in this invention can exert an effective preservative effect at a low addition amount, while avoiding the interference of crude extract impurities on product quality.

[0086] V. Tea seed cake premixing and dispersion effect and paste uniformity test 1. Test Protocol Prepare a mixed paste according to the method in Example 1. Take 0.3 parts of bamboo leaf extract and add it directly to the paste and stir to disperse. Then add tea seed powder and excipients as the direct addition group.

[0087] Tea seed cake premix powder was prepared according to the method in Example 2, and then added together with the remaining tea seed cake powder to form a mixed thick paste as a dry powder premix group.

[0088] Bamboo leaf extract-tea bran complex was prepared according to the method in Example 4, and then added together with the remaining tea bran powder to a mixed thick paste as a polysaccharide carrier pretreatment group.

[0089] The first tea seed powder was pre-granulated according to the method in Example 5, and then coated with a paste dispersion. Subsequent steps were continued to form the pre-granulation group.

[0090] Following the method in Example 6, tea oil was subjected to hydrophobic treatment after pre-granulation and before coating, and subsequent steps were continued to form the tea oil hydrophobic group.

[0091] Nine samples were collected from three layers (top, middle, and bottom) of the paste, with three samples taken from each layer. The content of bamboo leaf flavonoids was determined, and the coefficient of variation was calculated to evaluate the uniformity of dispersion. Additionally, the surface and cross-section of the paste were visually inspected for uneven coloring or granular spots.

[0092] 2. Testing Methods The flavonoid content in bamboo leaves was determined using ultraviolet spectrophotometry, with rutin as the standard, and absorbance measured at a wavelength of 510 nm. Dispersion uniformity was expressed as the coefficient of variation: coefficient of variation = standard deviation / mean × 100%, with a smaller value indicating more uniform dispersion.

[0093] 3. The experimental data are shown in Table 5.

[0094] Table 5: Uniformity of bamboo leaf flavonoid dispersion in ointments obtained by different processes 4. Data Analysis and Conclusions Table 5 shows that in the direct addition group, the bamboo leaf flavonoid powder was difficult to disperse evenly in the high-viscosity paste, resulting in large fluctuations in content at each sampling point and a coefficient of variation as high as 28.6%. Obvious yellowish-brown spots were visible on the paste surface, indicating severely uneven extract distribution and localized excessively high concentrations. In the dry powder premix group, by pre-mixing with some tea seed cake powder, the coefficient of variation decreased to 12.3%, and there were no obvious spots, indicating significantly improved dispersion uniformity. The polysaccharide carrier pretreatment group further reduced the coefficient of variation to 7.8%, indicating that polysaccharides made the flavonoids bind more tightly to the tea seed cake. The coefficients of variation for the pre-granulation group and the tea oil hydrophobication group decreased to 5.2% and 3.6%, respectively, indicating that the loose micro-aggregates formed by pre-granulation facilitated the uniform coating and penetration of the paste dispersion, while the tea oil hydrophobication further prevented the disintegration of micro-aggregates during coating, ultimately achieving a highly uniform dispersion of the extract in the paste.

[0095] The above experiments demonstrate that the progressively improved tea seed cake premixing and pretreatment process of this invention can effectively solve the technical problem of high-purity extracts being difficult to disperse evenly in viscous pastes, and the more optimized the process, the better the dispersion uniformity.

[0096] Although embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and embodiments. It can be applied to various fields suitable for the present invention. Further modifications can be readily implemented by those skilled in the art.

Claims

1. A natural shampoo for dandruff and itching relief, characterized in that, Including the following parts by weight of raw materials: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of tea seed cake, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, 15-25 parts of Sophora tonkinensis root, and 15-25 parts of Portulaca oleracea. The tea bran mentioned above is tea bran powder that has been aged for more than 6 months and pulverized to 80-100 mesh; The Sophora tonkinensis root mentioned is a Sophora tonkinensis root that has undergone processing to reduce its toxicity. The pH value of the natural shampoo for dandruff and itch relief is 5.0~6.

0.

2. The natural shampoo for dandruff and itch relief as described in claim 1, characterized in that, It also includes 0.5% to 2% of bamboo leaf extract or 0.1% to 1% of rosemary extract by weight of the total raw material; the bamboo leaf extract contains no less than 30% total flavonoids; the rosemary extract contains no less than 20% carrageenan acid and no less than 3% rosmarinic acid. The bamboo leaf extract was obtained by the following method: bamboo leaves were pulverized to 40-80 mesh; extracted by reflux with 8-12 times the amount of 50%-70% ethanol 2-3 times, each time for 1-2 hours, and the extracts were combined; ethanol was recovered under reduced pressure until the ethanol residue was less than 0.5%, and water was added to disperse the extract to a concentration of 0.1-0.2 g crude drug / mL; the extract was subjected to AB-8 or D101 macroporous adsorption resin column chromatography; ethanol was recovered under reduced pressure and the extract was dried under vacuum. The rosemary extract is obtained by the following method: dried rosemary leaves are pulverized to 20-40 mesh and extracted using supercritical CO2; the supercritical CO2 extraction pressure is 25-30 MPa, the temperature is 40-45℃, the extraction time is 2-3 hours, the CO2 flow rate is 15-25 L / kg raw material per hour, and the separation pressure is 6-8 MPa and the temperature is 35-40℃.

3. The natural shampoo for dandruff and itching as described in claim 1, characterized in that, The detoxification treatment mentioned above involves steaming with licorice juice or roasting with honey, specifically including: The process of steaming licorice juice is as follows: take slices of Sophora tonkinensis root, add 10% to 20% of the weight of the slices of Sophora tonkinensis root decoction and mix well. Seal and let it soak until the juice is absorbed. Then steam at 100 to 110°C for 2 to 4 hours, and then dry at a low temperature below 60°C until the moisture content is less than 9%. The honey-frying process is as follows: Take slices of Sophora tonkinensis root, add 15% to 25% of the weight of the slices of Sophora tonkinensis root and refined honey, mix well, seal and moisten for 2 to 4 hours, place in a frying container and fry continuously at 120 to 140°C until the surface of the slices turns dark yellow and is not sticky to the touch, let cool and sift out the debris.

4. The method for preparing the natural dandruff-reducing and anti-itch shampoo as described in any one of claims 1 to 3, characterized in that, include: The raw materials were obtained and mixed according to the following weight proportions: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, and 15-25 parts of Portulaca oleracea fruit. The mixture was decocted 2-3 times with water. The amount of water added for the first time was 8-12 times the total weight of the medicinal materials, and the amount of water added for the second and subsequent times was 6-10 times the total weight of the medicinal materials. Each decoction was 1-2 hours. The decoctions were combined and concentrated under reduced pressure at 60-70℃ and -0.08--0.09MPa to a water-extracted thick paste with a relative density of 1.05-1.

20. Take 15-25 parts of Sophora tonkinensis root, process it to reduce toxicity, then pulverize it to 20-40 mesh, add 6-10 times the amount of 60%-75% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, and recover the ethanol under reduced pressure at 55-65℃ and -0.08--0.09MPa and concentrate it until the ethanol residue is less than 0.5% to obtain the alcohol extract thick paste. Combine the water-extracted thick paste and the alcohol-extracted thick paste at 40-50°C and stir at 60-100 rpm for 10-20 minutes until homogeneous to obtain a mixed thick paste. Take 20-40 parts of tea seed cake and grind it to 80-100 mesh. Add it to the mixed paste in 2-3 portions. After each addition of the mixed paste, stir at 40-60 rpm for 5-10 minutes. Then add the shampoo excipients and stir at 40-60 rpm for 15-30 minutes. Adjust the pH value to 5.0-6.0 to obtain the natural shampoo for removing dandruff and relieving itching.

5. The method for preparing the natural dandruff-reducing and anti-itch shampoo as described in claim 4, characterized in that, The natural preservative is bamboo leaf extract, and the process includes the following steps: The raw materials were obtained and mixed according to the following weight proportions: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, and 15-25 parts of Portulaca oleracea fruit. The mixture was decocted 2-3 times with water. The amount of water added for the first time was 8-12 times the total weight of the medicinal materials, and the amount of water added for the second and subsequent times was 6-10 times the total weight of the medicinal materials. Each decoction was 1-2 hours. The decoctions were combined and concentrated under reduced pressure at 60-70℃ and -0.08--0.09MPa to a water-extracted thick paste with a relative density of 1.05-1.

20. Take 15-25 parts of Sophora tonkinensis root, process it to reduce toxicity, then pulverize it to 20-40 mesh, add 6-10 times the amount of 60%-75% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, and recover the ethanol under reduced pressure at 55-65℃ and -0.08--0.09MPa and concentrate it until the ethanol residue is less than 0.5% to obtain the alcohol extract thick paste. Combine the water-extracted thick paste and the alcohol-extracted thick paste at 40-50°C and stir at 60-100 rpm for 10-20 minutes until homogeneous to obtain a mixed thick paste. Take 20-40 parts of tea seed cake and grind it to 80-100 mesh to obtain tea seed cake powder; take 0.5%-2% of the total weight of bamboo leaf extract of the raw material and 10%-30% of the total weight of the tea seed cake powder and stir and mix them at 30-50 rpm for 5-15 minutes until the powder color is uniform to obtain tea seed cake premixed powder. Add the premixed tea seed powder and the remaining tea seed powder to the mixed paste in 2-3 batches. After each addition, stir at a speed of 40-60 rpm for 5-10 minutes. Then add the moisturizer, thickener, and surfactant and stir at a speed of 40-60 rpm for 15-30 minutes. Adjust the pH value to 5.0-6.0 to obtain the natural shampoo for dandruff and itch relief.

6. The method for preparing the natural dandruff-reducing and anti-itch shampoo as described in claim 4, characterized in that, When the natural preservative is rosemary extract, the following steps are included: The raw materials were obtained and mixed according to the following weight proportions: 20-40 parts of Dictamnus dasycarpus root bark, 20-40 parts of Kochia scoparia fruit, 20-40 parts of Cnidium monnieri fruit, 15-25 parts of Morus alba root bark, and 15-25 parts of Portulaca oleracea fruit. The mixture was decocted 2-3 times with water. The amount of water added for the first time was 8-12 times the total weight of the medicinal materials, and the amount of water added for the second and subsequent times was 6-10 times the total weight of the medicinal materials. Each decoction was 1-2 hours. The decoctions were combined and concentrated under reduced pressure at 60-70℃ and -0.08--0.09MPa to a water-extracted thick paste with a relative density of 1.05-1.

20. Take 15-25 parts of Sophora tonkinensis root, process it to reduce toxicity, then pulverize it to 20-40 mesh, add 6-10 times the amount of 60%-75% ethanol, reflux extract 2-3 times, 1-2 hours each time, combine the extracts, and recover the ethanol under reduced pressure at 55-65℃ and -0.08--0.09MPa and concentrate it until the ethanol residue is less than 0.5% to obtain the alcohol extract thick paste. Combine the water-extracted thick paste and the alcohol-extracted thick paste at 40-50°C and stir at 60-100 rpm for 10-20 minutes until homogeneous to obtain a mixed thick paste. Take 20-40 parts of tea seed cake and grind it to 80-100 mesh to obtain tea seed cake powder; first, add 0.1%-1% of the total weight of the raw material rosemary extract to 2-5 times its own weight of 75%-95% ethanol, and stir at 25-35℃ until completely dissolved to obtain a rosemary alcohol solution; then, under stirring, uniformly spray the rosemary alcohol solution onto 10%-30% of the total weight of the tea seed cake powder, and then dry under reduced pressure at 30-40℃ and -0.08--0.09MPa for 30-60 minutes to remove ethanol and obtain a second premixed powder; Add the second premixed powder and the remaining tea seed powder to the mixed paste in 2-3 batches. After each addition, stir at a speed of 40-60 rpm for 5-10 minutes. Then add the humectant, thickener, and surfactant and stir at a speed of 40-60 rpm for 15-30 minutes. Adjust the pH value to 5.0-6.0 to obtain the natural shampoo for dandruff and itch relief.

7. The method for preparing the natural dandruff-reducing and anti-itch shampoo as described in claim 5, characterized in that, Before preparing the tea seed cake premix powder, the method further includes pretreatment of bamboo leaf extract, specifically including: Bamboo leaf extract was co-ground with a natural polysaccharide carrier at a ratio of 1:0.2 to 0.5 by weight. The natural polysaccharide carrier was any one of maltodextrin, gum arabic, or hydroxypropyl-β-cyclodextrin. The grinding speed was 60 to 100 rpm and the grinding time was 10 to 20 minutes to obtain a grinding mixture. Add 10% to 20% of the total weight of the ground mixture and 50% to 70% of the volume of the ethanol solution to the mixture. Gradually heat the mixture to 45 to 55°C while stirring at 40 to 60 rpm. Keep the mixture warm and continue stirring for 20 to 30 minutes to form a paste-like dispersion. Take 20-40 parts of tea seed cake and grind it to 80-100 mesh to obtain tea seed cake powder; divide the tea seed cake powder into two parts in a weight ratio of 1-3:7-9, with the first tea seed cake powder accounting for 10%-30% of the total weight of the tea seed cake powder; evenly coat the paste dispersion on the surface of the first tea seed cake powder, place it in a vacuum drying oven, and dry it under reduced pressure at 40-50℃ and -0.08--0.09MPa for 60-90 minutes, while turning the material over every 15 minutes, until the moisture content is less than 5%, cool it to room temperature, and pass it through a 60-mesh sieve to obtain the bamboo leaf extract-tea seed cake complex; Add the bamboo leaf extract-tea bran complex and the remaining tea bran powder to the mixed paste in 2-3 batches. After each addition, stir at 40-60 rpm for 5-10 minutes. Then add the moisturizer, thickener and surfactant and stir at 40-60 rpm for 15-30 minutes. Adjust the pH value to 5.0-6.0 to obtain the natural shampoo for dandruff and itch relief.

8. The method for preparing the natural dandruff-reducing and itch-relieving shampoo as described in claim 7, characterized in that, After the paste dispersion is evenly coated on the surface of the first tea seed powder and before it is placed in a vacuum drying oven, the following steps are also included: Transfer the first tea seed cake powder coated with the paste dispersion to a sealed container and let it stand at 20-30°C for 30-60 minutes, allowing the ethanol-water system in the paste dispersion to naturally penetrate into the tea seed cake powder particles through capillary action; keep the container sealed during the standing period and control the relative humidity at 65%-75%. Spread the tea seed powder evenly on a tray and place it at 30-35℃ and normal pressure for 15-30 minutes to allow excess solvent on the surface to evaporate until the material is in a state where it does not clump when squeezed and can be easily dispersed by light touch. Then place it in a vacuum drying oven for subsequent reduced pressure drying.

9. The method for preparing the natural dandruff-reducing and anti-itch shampoo as described in claim 8, characterized in that, Before uniformly coating the paste dispersion onto the surface of the first tea seed cake powder, the process also includes pretreatment of the first tea seed cake powder: The first tea seed cake powder is placed in a mixer equipped with a spray device. While stirring at 40-60 rpm, 3%-8% of its weight of deionized water is evenly sprayed onto the surface of the first tea seed cake powder. The spray particle size is controlled at 10-30 μm. Stirring is continued for 3-8 minutes to make the surface of the first tea seed cake powder particles slightly moist and form loose micro-agglomerates. Then, the micro-agglomerates are ventilated and dried at 30-35°C and 50%-60% relative humidity for 10-15 minutes until the moisture content of the micro-agglomerates returns to the level before spraying and maintains the agglomerated morphology, thus obtaining the pre-granulated first tea seed cake powder. The paste-like dispersion is evenly coated onto the surface of the pre-granulated first tea bran powder.

10. The method for preparing the natural dandruff-reducing and anti-itch shampoo as described in claim 9, characterized in that, After obtaining the pre-granulated first tea seed cake powder and before uniformly coating the paste dispersion onto the surface of the pre-granulated first tea seed cake powder, the following steps are also included: The pre-granulated first tea seed powder and 0.2% to 0.5% of cold-pressed tea oil by weight are placed in a mixer and mixed for 5 to 10 minutes at 15 to 25°C and 20 to 30 rpm to form a hydrophobic oil film on the surface of the micro-aggregates, thus obtaining surface-hydrophobic micro-aggregates; then, a paste dispersion is evenly coated on the surface of the surface-hydrophobic micro-aggregates.

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