Medicinal composition for preventing senile dementia and improving memory
Patent Information
- Application Number
- CN202510168518.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-17
- Publication Date
- 2026-08-18
AI Technical Summary
[0002]The purpose of this invention is to provide a health product that is low in production cost, purely herbal and green, and effective in preventing and treating Alzheimer's disease. It contains 1-3 parts Cistanche deserticola extract, 1-3 parts Astragalus membranaceus extract, and 1-3 parts Pueraria lobata powder. It can be made into granules, capsules, soft capsules, powders, pills, and decoctions. The manufacturing process is simple and low in cost. It is made entirely from natural plants, contains no hormones, and does not contain pigments or other synthetic chemicals. Continuous use has no toxic side effects on the human body. The process includes the following steps: S1. First, prepare the medicinal materials, including Astragalus membranaceus extract, Cistanche deserticola extract, and Pueraria lobata extract, and place them in different containers for later use; S2. Mix starch, powdered sugar, microcrystalline cellulose, and sodium carboxymethyl starch evenly and pass them through an 80-mesh sieve, and set them aside as excipients; S3. Add the excipients prepared in S2 to the Astragalus membranaceus extract, Cistanche deserticola extract, and Pueraria lobata powder prepared in S1 for granulation, drying, and tableting, thus completing the preparation of the finished tablets; S4. Perform polysaccharide extraction on the finished tablets from S3. The characteristic feature is that the preparation steps of Astragalus membranaceus extract in S1 are as follows: Place 5-7 parts of Astragalus membranaceus in a container, add 10 times the amount of water, and extract ultrasonically at 70°C for 30 minutes. Filter the mixture, add 8 times the amount of water to the residue, extract ultrasonically for 30 minutes, filter the mixture again, combine the two filtrates, and concentrate them into an extract of 1 g/ml. The preparation steps of kudzu powder in S1 are as follows: Take 3-6 parts of kudzu root, crush it, and pass it through an 80-mesh sieve for later use. The specific implementation steps of S3 are as follows: S301, add the prepared excipients to Astragalus extract, Cistanche extract, and kudzu powder and mix them evenly to form a soft material, then granulate it through an 18-mesh sieve to form wet granules; S302, dry the wet granules at 80℃ for 2 hours and then granulate them through an 18-mesh sieve; S303, add sodium carboxymethyl starch and 0.2% magnesium stearate to the granulated granules and mix them evenly, and then compress them into tablets. The polysaccharide extraction steps in S4 are as follows: S401, soak the tablets in hot ethanol for 3 hours, filter with gauze, discard the filtrate, and keep the residue; S402, decoct the residue with water 3 times, 1-2 hours each time, filter and combine the filtrates; S403, after evaporating and concentrating the filtrate, centrifuge to remove the precipitate, precipitate the supernatant with 2-3 times the volume of 95% ethanol, let it stand at 4℃ for 24 hours, and centrifuge at 4℃ for 20 minutes the next day at a speed of 5500-6000 r/min, and collect the precipitate; S404, the above precipitate is reconstituted with water, deproteinized and dialyzed, and freeze-dried to obtain polysaccharides.
Abstract
Description
[0001] Over the past three decades, the incidence and mortality rates of Alzheimer's disease (AD) have risen rapidly, becoming the fifth leading cause of death among urban and rural residents in China. China is facing a tremendous challenge posed by Alzheimer's disease. The "China Alzheimer's Disease Report 2024" shows that in 2021, the number of people with AD and other dementias in my country reached 16,990,827. The prevalence and mortality rates of Alzheimer's disease increase with age, and the data for women are higher than for men. Currently, the drugs approved by the State Food and Drug Administration for the treatment of AD are mainly cholinesterase inhibitors and NMDA receptor antagonists. These drugs only regulate the levels of neurotransmitters in the brain, improving early AD symptoms. There is hope that drugs that protect neurons and slow the progression of AD include neurotrophic factors, drugs that improve nerve cell metabolism, and traditional Chinese medicine. According to *Yilin Gaicuo* (a medical text), "Those who lose their memory in old age have gradually emptied their brain marrow. As people age, the functions of the internal organs decline, the marrow sea becomes insufficient, the brain is deprived of nourishment, and thus the mind loses its function." This indicates that the depletion of marrow in the brain is the root cause of Alzheimer's disease. Summary of the Invention
[0002] The purpose of this invention is to provide a health product that is low in production cost, purely herbal and green, and effective in preventing and treating Alzheimer's disease. It contains 1-3 parts Cistanche deserticola extract, 1-3 parts Astragalus membranaceus extract, and 1-3 parts Pueraria lobata powder. It can be made into granules, capsules, soft capsules, powders, pills, and decoctions. The manufacturing process is simple and low in cost. It is made entirely from natural plants, contains no hormones, and does not contain pigments or other synthetic chemicals. Continuous use has no toxic side effects on the human body. The process includes the following steps: S1. First, prepare the medicinal materials, including Astragalus membranaceus extract, Cistanche deserticola extract, and Pueraria lobata extract, and place them in different containers for later use; S2. Mix starch, powdered sugar, microcrystalline cellulose, and sodium carboxymethyl starch evenly and pass them through an 80-mesh sieve, and set them aside as excipients; S3. Add the excipients prepared in S2 to the Astragalus membranaceus extract, Cistanche deserticola extract, and Pueraria lobata powder prepared in S1 for granulation, drying, and tableting, thus completing the preparation of the finished tablets; S4. Perform polysaccharide extraction on the finished tablets from S3. The characteristic feature is that the preparation steps of Astragalus membranaceus extract in S1 are as follows: Place 5-7 parts of Astragalus membranaceus in a container, add 10 times the amount of water, and extract ultrasonically at 70°C for 30 minutes. Filter the mixture, add 8 times the amount of water to the residue, extract ultrasonically for 30 minutes, filter the mixture again, combine the two filtrates, and concentrate them into an extract of 1 g / ml. The preparation steps of kudzu powder in S1 are as follows: Take 3-6 parts of kudzu root, crush it, and pass it through an 80-mesh sieve for later use. The specific implementation steps of S3 are as follows: S301, add the prepared excipients to Astragalus extract, Cistanche extract, and kudzu powder and mix them evenly to form a soft material, then granulate it through an 18-mesh sieve to form wet granules; S302, dry the wet granules at 80℃ for 2 hours and then granulate them through an 18-mesh sieve; S303, add sodium carboxymethyl starch and 0.2% magnesium stearate to the granulated granules and mix them evenly, and then compress them into tablets. The polysaccharide extraction steps in S4 are as follows: S401, soak the tablets in hot ethanol for 3 hours, filter with gauze, discard the filtrate, and keep the residue; S402, decoct the residue with water 3 times, 1-2 hours each time, filter and combine the filtrates; S403, after evaporating and concentrating the filtrate, centrifuge to remove the precipitate, precipitate the supernatant with 2-3 times the volume of 95% ethanol, let it stand at 4℃ for 24 hours, and centrifuge at 4℃ for 20 minutes the next day at a speed of 5500-6000 r / min, and collect the precipitate; S404, the above precipitate is reconstituted with water, deproteinized and dialyzed, and freeze-dried to obtain polysaccharides.
[0003] According to the "Classified Treatment of Diseases", blood stasis in the brain can cause forgetfulness and madness. Blood stasis in the brain can also cause the brain to become blocked and the sensory organs to become dysfunctional, leading to dementia. Background Technology
[0004] Statistics show that the prevalence of dementia (Alzheimer's disease, vascular dementia and other dementias) and mild cognitive impairment is very high in China.
[0005] In China, among people aged 60 and older, the age- and sex-adjusted prevalence of dementia is approximately 6.0%, Alzheimer's disease 3.9%, vascular dementia 1.6%, and other types of dementia 0.5%. This equates to 15.07 million people aged 60 and older in China having dementia, 9.83 million having Alzheimer's disease, 3.92 million having vascular dementia, and 1.32 million having other types of dementia. Prevalence varies across different regions of China, with rates of 6.3% in northern China, 4.7% in southern China, and 7.5% in western China. Aging is accompanied by changes in the brain, including atrophy (especially in the hippocampus), an imbalance in the production and degradation of β-amyloid protein, activation of inflammation, and degeneration of neurons in memory-related areas. Women have a higher prevalence across all age groups, likely due to decreased estrogen and related hormones after menopause and differences in benign brain structure. A family history of dementia increases genetic susceptibility to the disease. In addition, there are up to nine modifiable risk factors: rural residents, short education duration, widowed or divorced or living alone, smoking, high blood pressure, high cholesterol, diabetes, heart disease, and cerebrovascular disease.
[0006] Cistanche deserticola, a traditional Chinese medicine, tonifies kidney yang and nourishes essence and blood. It is commonly used to treat neurological disorders. Modern research has found that Cistanche deserticola has a protective effect on brain nerves and is not only used for Alzheimer's disease but also frequently used to treat Parkinson's disease, vascular dementia, and other diseases. This paper summarizes the neuroprotective effects of Cistanche deserticola based on relevant research progress, providing a scientific basis and reference for the prevention and treatment of Alzheimer's disease. The earliest record of Cistanche deserticola's effects is found in the *Shennong Bencao Jing* (Shennong's Classic of Materia Medica): "It treats five types of fatigue and seven types of injury, tonifies the middle jiao, removes cold and heat pain in the penis, nourishes the five internal organs, regulates yin and benefits essence and qi."
Claims
1. This product is a combination of drugs for preventing Alzheimer's disease and improving memory, characterized in that... The following components and proportions are used: Cistanche deserticola extract (1-3g), Astragalus membranaceus extract (1-3g), and Pueraria lobata powder (1-3g) are used to make granules, capsules, soft capsules, powders, pills, and decoctions. The manufacturing process is simple and low-cost. It is made entirely from natural plants, contains no hormones, pigments, or other chemically synthesized products, and has no toxic side effects after continuous use. This traditional Chinese medicine contains easily absorbed flavonoids, saponins, phenolic acids, alkaloids, and polysaccharides, effectively tonifying the kidneys and brain, replenishing qi and clearing turbidity, promoting blood circulation and detoxifying. It is suitable for mild cognitive impairment due to deficiency of essence and qi, and for the prevention of Alzheimer's disease (AD). The effective components extracted from this traditional Chinese medicine have multiple effects, including inhibiting brain iron overload in AD and alleviating the central nervous system functional decline caused by brain iron overload.
2. The method for preparing a Cistanche deserticola health product for preventing Alzheimer's disease and improving memory according to claim 1, characterized in that, Includes the following steps: S1. First, prepare the medicinal materials, including Astragalus membranaceus extract, Cistanche deserticola extract, and Pueraria lobata extract, and place them in separate containers for later use. S2. Mix starch, powdered sugar, microcrystalline cellulose, and sodium carboxymethyl starch evenly and pass through an 80-mesh sieve; these will be used as excipients. S3. Add the excipients prepared in S2 to the Astragalus membranaceus extract, Cistanche deserticola extract, and Pueraria lobata powder prepared in S1 for granulation, drying, and tableting to complete the preparation of the finished tablets. S4. Perform polysaccharide extraction on the finished tablets from S3.
3. The preparation method of a Cistanche deserticola health product for preventing Alzheimer's disease and improving memory according to claim 2, characterized in that, The preparation steps of S1 Astragalus extract are as follows: 5-7 parts of Astragalus are placed in a container, and 10 times the amount of water is added. The mixture is ultrasonically extracted at 70°C for 30 minutes and then filtered. The residue is then added to 8 times the amount of water and ultrasonically extracted for 30 minutes. The residue is then filtered again. The two filtrates are combined and concentrated to an extract of 1g / ml.
4. The method for preparing a Cistanche deserticola health product for preventing Alzheimer's disease and improving memory according to claim 1, characterized in that, The preparation steps of kudzu powder in S1 are as follows: Take 3-6 parts of kudzu root, crush it, and pass it through an 80-mesh sieve for later use.
5. The preparation method of a Cistanche deserticola health product for preventing Alzheimer's disease and improving memory according to claim 1, characterized in that, The specific implementation steps of S3 are as follows: S301, add the prepared excipients to Astragalus extract, Cistanche extract and kudzu powder and mix evenly to form a soft material, then granulate through an 18-mesh sieve to form wet granules; S302, dry the wet granules at 80°C for 2 hours and granulate through an 18-mesh sieve; S303, add the granulated granules to sodium carboxymethyl starch and 0.2% magnesium stearate and mix evenly, then compress into tablets.
6. The method for preparing a Cistanche deserticola health product for preventing Alzheimer's disease and improving memory according to claim 1, characterized in that, The polysaccharide extraction steps in S4 are as follows: S401, soak the tablets in hot ethanol for 3 hours, filter with gauze, discard the filtrate, and keep the residue; S402, decoct the residue with water 3 times, 1-2 hours each time, filter and combine the filtrates; S403, after evaporating and concentrating the filtrate, centrifuge to remove the precipitate, precipitate the supernatant with 2-3 times the volume of 95% ethanol, let stand at 4℃ for 24 hours, centrifuge at 4℃ for 20 minutes the next day at a speed of 5500-6000 r / min, and collect the precipitate; S404, the above precipitate is reconstituted with water, deproteinized by dialyzing, and freeze-dried to obtain polysaccharides.